-- dump date 20140619_230332 -- class Genbank::misc_feature -- table misc_feature_note -- id note 694427000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 694427000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 694427000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427000004 Walker A motif; other site 694427000005 ATP binding site [chemical binding]; other site 694427000006 Walker B motif; other site 694427000007 arginine finger; other site 694427000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 694427000009 DnaA box-binding interface [nucleotide binding]; other site 694427000010 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 694427000011 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 694427000012 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 694427000013 FAD binding domain; Region: FAD_binding_4; pfam01565 694427000014 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 694427000015 YceG-like family; Region: YceG; pfam02618 694427000016 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 694427000017 dimerization interface [polypeptide binding]; other site 694427000018 Helix-turn-helix domain; Region: HTH_18; pfam12833 694427000019 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427000020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427000021 ATP binding site [chemical binding]; other site 694427000022 Mg2+ binding site [ion binding]; other site 694427000023 G-X-G motif; other site 694427000024 B12 binding domain; Region: B12-binding; pfam02310 694427000025 B12 binding site [chemical binding]; other site 694427000026 Transposase IS200 like; Region: Y1_Tnp; cl00848 694427000027 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 694427000028 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427000029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427000030 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 694427000031 Coenzyme A binding pocket [chemical binding]; other site 694427000032 Flavin Reductases; Region: FlaRed; cl00801 694427000033 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 694427000034 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427000035 DNA binding residues [nucleotide binding] 694427000036 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 694427000037 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 694427000038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427000039 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 694427000040 Walker A/P-loop; other site 694427000041 ATP binding site [chemical binding]; other site 694427000042 Q-loop/lid; other site 694427000043 ABC transporter signature motif; other site 694427000044 Walker B; other site 694427000045 D-loop; other site 694427000046 H-loop/switch region; other site 694427000047 ABC-2 type transporter; Region: ABC2_membrane; cl17235 694427000048 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 694427000049 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 694427000050 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427000051 catalytic residues [active] 694427000052 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 694427000053 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 694427000054 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 694427000055 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427000056 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427000057 DNA binding residues [nucleotide binding] 694427000058 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 694427000059 Predicted membrane protein [Function unknown]; Region: COG2855 694427000060 Transcriptional regulator [Transcription]; Region: LysR; COG0583 694427000061 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 694427000062 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 694427000063 putative dimerization interface [polypeptide binding]; other site 694427000064 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 694427000065 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 694427000066 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 694427000067 catalytic triad [active] 694427000068 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 694427000069 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 694427000070 DAK2 domain; Region: Dak2; pfam02734 694427000071 EDD domain protein, DegV family; Region: DegV; TIGR00762 694427000072 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 694427000073 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 694427000074 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 694427000075 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 694427000076 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427000077 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427000078 catalytic residues [active] 694427000079 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 694427000080 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 694427000081 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 694427000082 active site 694427000083 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 694427000084 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 694427000085 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 694427000086 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 694427000087 Putative esterase; Region: Esterase; pfam00756 694427000088 S-formylglutathione hydrolase; Region: PLN02442 694427000089 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 694427000090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694427000091 dimer interface [polypeptide binding]; other site 694427000092 conserved gate region; other site 694427000093 putative PBP binding loops; other site 694427000094 ABC-ATPase subunit interface; other site 694427000095 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 694427000096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694427000097 dimer interface [polypeptide binding]; other site 694427000098 conserved gate region; other site 694427000099 putative PBP binding loops; other site 694427000100 ABC-ATPase subunit interface; other site 694427000101 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 694427000102 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 694427000103 Walker A/P-loop; other site 694427000104 ATP binding site [chemical binding]; other site 694427000105 Q-loop/lid; other site 694427000106 ABC transporter signature motif; other site 694427000107 Walker B; other site 694427000108 D-loop; other site 694427000109 H-loop/switch region; other site 694427000110 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 694427000111 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 694427000112 ATP binding site [chemical binding]; other site 694427000113 Mg++ binding site [ion binding]; other site 694427000114 motif III; other site 694427000115 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427000116 nucleotide binding region [chemical binding]; other site 694427000117 ATP-binding site [chemical binding]; other site 694427000118 para-aminobenzoate synthase component I; Validated; Region: PRK07093 694427000119 hypothetical protein; Provisional; Region: PRK07101 694427000120 2-isopropylmalate synthase; Validated; Region: PRK00915 694427000121 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 694427000122 active site 694427000123 catalytic residues [active] 694427000124 metal binding site [ion binding]; metal-binding site 694427000125 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 694427000126 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 694427000127 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 694427000128 substrate binding site [chemical binding]; other site 694427000129 ligand binding site [chemical binding]; other site 694427000130 GxxExxY protein; Region: GxxExxY; TIGR04256 694427000131 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 694427000132 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 694427000133 substrate binding site [chemical binding]; other site 694427000134 (R)-citramalate synthase; Provisional; Region: PRK09389 694427000135 Leptospira interrogans citramalate synthase (CMS) and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_CMS; cd07945 694427000136 active site 694427000137 catalytic residues [active] 694427000138 metal binding site [ion binding]; metal-binding site 694427000139 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 694427000140 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 694427000141 tartrate dehydrogenase; Region: TTC; TIGR02089 694427000142 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 694427000143 catalytic residues [active] 694427000144 dimer interface [polypeptide binding]; other site 694427000145 Transcriptional regulators [Transcription]; Region: MarR; COG1846 694427000146 MarR family; Region: MarR; pfam01047 694427000147 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 694427000148 catalytic residues [active] 694427000149 dimer interface [polypeptide binding]; other site 694427000150 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427000151 TPR motif; other site 694427000152 binding surface 694427000153 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427000154 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 694427000155 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 694427000156 substrate binding site [chemical binding]; other site 694427000157 ATP binding site [chemical binding]; other site 694427000158 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 694427000159 EamA-like transporter family; Region: EamA; pfam00892 694427000160 EamA-like transporter family; Region: EamA; pfam00892 694427000161 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 694427000162 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 694427000163 putative acyl-acceptor binding pocket; other site 694427000164 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 694427000165 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 694427000166 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 694427000167 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 694427000168 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 694427000169 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 694427000170 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 694427000171 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 694427000172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427000173 ATP binding site [chemical binding]; other site 694427000174 Mg2+ binding site [ion binding]; other site 694427000175 G-X-G motif; other site 694427000176 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 694427000177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427000178 active site 694427000179 phosphorylation site [posttranslational modification] 694427000180 intermolecular recognition site; other site 694427000181 dimerization interface [polypeptide binding]; other site 694427000182 Helix-turn-helix domain; Region: HTH_18; pfam12833 694427000183 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427000184 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427000185 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427000186 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427000187 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427000188 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 694427000189 active site 694427000190 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 694427000191 putative substrate binding site [chemical binding]; other site 694427000192 active site 694427000193 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 694427000194 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 694427000195 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 694427000196 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 694427000197 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 694427000198 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 694427000199 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 694427000200 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 694427000201 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 694427000202 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 694427000203 hypothetical protein; Provisional; Region: PRK10621 694427000204 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 694427000205 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 694427000206 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694427000207 DNA binding site [nucleotide binding] 694427000208 TraB family; Region: TraB; pfam01963 694427000209 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 694427000210 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 694427000211 Walker A/P-loop; other site 694427000212 ATP binding site [chemical binding]; other site 694427000213 Q-loop/lid; other site 694427000214 ABC transporter signature motif; other site 694427000215 Walker B; other site 694427000216 D-loop; other site 694427000217 H-loop/switch region; other site 694427000218 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694427000219 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 694427000220 FtsX-like permease family; Region: FtsX; pfam02687 694427000221 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694427000222 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 694427000223 FtsX-like permease family; Region: FtsX; pfam02687 694427000224 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427000225 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 694427000226 HlyD family secretion protein; Region: HlyD_3; pfam13437 694427000227 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 694427000228 Predicted transcriptional regulators [Transcription]; Region: COG1695 694427000229 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 694427000230 phage shock protein C; Region: phageshock_pspC; TIGR02978 694427000231 PspC domain; Region: PspC; pfam04024 694427000232 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 694427000233 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 694427000234 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 694427000235 glycine dehydrogenase; Provisional; Region: PRK05367 694427000236 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 694427000237 tetramer interface [polypeptide binding]; other site 694427000238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427000239 catalytic residue [active] 694427000240 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 694427000241 tetramer interface [polypeptide binding]; other site 694427000242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427000243 catalytic residue [active] 694427000244 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 694427000245 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 694427000246 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 694427000247 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 694427000248 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 694427000249 ATP binding site [chemical binding]; other site 694427000250 Mg++ binding site [ion binding]; other site 694427000251 motif III; other site 694427000252 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427000253 nucleotide binding region [chemical binding]; other site 694427000254 ATP-binding site [chemical binding]; other site 694427000255 pyruvate phosphate dikinase; Provisional; Region: PRK09279 694427000256 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 694427000257 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 694427000258 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 694427000259 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 694427000260 Clp amino terminal domain; Region: Clp_N; pfam02861 694427000261 Clp amino terminal domain; Region: Clp_N; pfam02861 694427000262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427000263 Walker A motif; other site 694427000264 ATP binding site [chemical binding]; other site 694427000265 Walker B motif; other site 694427000266 arginine finger; other site 694427000267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427000268 Walker A motif; other site 694427000269 ATP binding site [chemical binding]; other site 694427000270 Walker B motif; other site 694427000271 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 694427000272 Uncharacterized conserved protein [Function unknown]; Region: COG2353 694427000273 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 694427000274 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 694427000275 minor groove reading motif; other site 694427000276 helix-hairpin-helix signature motif; other site 694427000277 substrate binding pocket [chemical binding]; other site 694427000278 active site 694427000279 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 694427000280 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 694427000281 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 694427000282 AP (apurinic/apyrimidinic) site pocket; other site 694427000283 DNA interaction; other site 694427000284 Metal-binding active site; metal-binding site 694427000285 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427000286 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 694427000287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427000288 putative substrate translocation pore; other site 694427000289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427000290 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 694427000291 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 694427000292 putative substrate binding site [chemical binding]; other site 694427000293 putative ATP binding site [chemical binding]; other site 694427000294 Transcriptional regulators [Transcription]; Region: PurR; COG1609 694427000295 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 694427000296 DNA binding site [nucleotide binding] 694427000297 domain linker motif; other site 694427000298 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 694427000299 dimerization interface [polypeptide binding]; other site 694427000300 ligand binding site [chemical binding]; other site 694427000301 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 694427000302 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 694427000303 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 694427000304 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 694427000305 active site 694427000306 NTP binding site [chemical binding]; other site 694427000307 metal binding triad [ion binding]; metal-binding site 694427000308 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 694427000309 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 694427000310 Zn2+ binding site [ion binding]; other site 694427000311 Mg2+ binding site [ion binding]; other site 694427000312 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 694427000313 N-terminal catalytic domain of a thermoactive alpha-amylase from Methanococcus jannaschii and similar proteins; glycoside hydrolase family 57 (GH57); Region: GH57N_MJA1_like; cd10795 694427000314 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 694427000315 putative active site [active] 694427000316 catalytic site [active] 694427000317 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 694427000318 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427000319 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 694427000320 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 694427000321 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 694427000322 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 694427000323 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 694427000324 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Region: LPLAT_AAK14816-like; cd07992 694427000325 putative acyl-acceptor binding pocket; other site 694427000326 bile acid transporter; Region: bass; TIGR00841 694427000327 Sodium Bile acid symporter family; Region: SBF; cl17470 694427000328 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 694427000329 active site 694427000330 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 694427000331 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 694427000332 putative hydrolase; Provisional; Region: PRK02113 694427000333 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 694427000334 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 694427000335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427000336 S-adenosylmethionine binding site [chemical binding]; other site 694427000337 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 694427000338 hypothetical protein; Provisional; Region: PRK08201 694427000339 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 694427000340 metal binding site [ion binding]; metal-binding site 694427000341 putative dimer interface [polypeptide binding]; other site 694427000342 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 694427000343 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 694427000344 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 694427000345 ABC transporter; Region: ABC_tran_2; pfam12848 694427000346 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 694427000347 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 694427000348 substrate binding pocket [chemical binding]; other site 694427000349 substrate-Mg2+ binding site; other site 694427000350 aspartate-rich region 1; other site 694427000351 aspartate-rich region 2; other site 694427000352 phytoene desaturase; Region: crtI_fam; TIGR02734 694427000353 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 694427000354 RDD family; Region: RDD; pfam06271 694427000355 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 694427000356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427000357 NAD(P) binding site [chemical binding]; other site 694427000358 active site 694427000359 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 694427000360 putative sugar binding site [chemical binding]; other site 694427000361 catalytic residues [active] 694427000362 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 694427000363 heme-binding site [chemical binding]; other site 694427000364 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 694427000365 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 694427000366 TPP-binding site; other site 694427000367 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 694427000368 PYR/PP interface [polypeptide binding]; other site 694427000369 dimer interface [polypeptide binding]; other site 694427000370 TPP binding site [chemical binding]; other site 694427000371 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 694427000372 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 694427000373 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 694427000374 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 694427000375 PYR/PP interface [polypeptide binding]; other site 694427000376 dimer interface [polypeptide binding]; other site 694427000377 TPP binding site [chemical binding]; other site 694427000378 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 694427000379 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 694427000380 TPP-binding site [chemical binding]; other site 694427000381 dimer interface [polypeptide binding]; other site 694427000382 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 694427000383 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 694427000384 putative valine binding site [chemical binding]; other site 694427000385 dimer interface [polypeptide binding]; other site 694427000386 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 694427000387 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 694427000388 active site 694427000389 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 694427000390 active site 2 [active] 694427000391 active site 1 [active] 694427000392 ketol-acid reductoisomerase; Validated; Region: PRK05225 694427000393 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 694427000394 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 694427000395 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 694427000396 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 694427000397 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427000398 Walker A motif; other site 694427000399 ATP binding site [chemical binding]; other site 694427000400 Walker B motif; other site 694427000401 arginine finger; other site 694427000402 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 694427000403 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 694427000404 Septum formation initiator; Region: DivIC; pfam04977 694427000405 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 694427000406 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 694427000407 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 694427000408 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 694427000409 Sporulation related domain; Region: SPOR; pfam05036 694427000410 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 694427000411 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 694427000412 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 694427000413 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 694427000414 putative active site [active] 694427000415 PhoH-like protein; Region: PhoH; pfam02562 694427000416 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 694427000417 Glycogen synthase; Region: Glycogen_syn; pfam05693 694427000418 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 694427000419 putative homodimer interface [polypeptide binding]; other site 694427000420 putative active site pocket [active] 694427000421 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 694427000422 hypothetical protein; Validated; Region: PRK02101 694427000423 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 694427000424 active site 694427000425 ADP/pyrophosphate binding site [chemical binding]; other site 694427000426 dimerization interface [polypeptide binding]; other site 694427000427 allosteric effector site; other site 694427000428 fructose-1,6-bisphosphate binding site; other site 694427000429 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 694427000430 DEAD-like helicases superfamily; Region: DEXDc; smart00487 694427000431 ATP binding site [chemical binding]; other site 694427000432 Mg++ binding site [ion binding]; other site 694427000433 motif III; other site 694427000434 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427000435 nucleotide binding region [chemical binding]; other site 694427000436 ATP-binding site [chemical binding]; other site 694427000437 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 694427000438 RNA binding site [nucleotide binding]; other site 694427000439 ethanolamine permease; Region: 2A0305; TIGR00908 694427000440 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 694427000441 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 694427000442 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 694427000443 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 694427000444 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 694427000445 Transglycosylase; Region: Transgly; cl17702 694427000446 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 694427000447 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 694427000448 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 694427000449 active site 694427000450 substrate binding site [chemical binding]; other site 694427000451 metal binding site [ion binding]; metal-binding site 694427000452 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 694427000453 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 694427000454 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 694427000455 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 694427000456 nucleotide binding site [chemical binding]; other site 694427000457 substrate binding site [chemical binding]; other site 694427000458 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 694427000459 dimer interface [polypeptide binding]; other site 694427000460 putative threonine allosteric regulatory site; other site 694427000461 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 694427000462 putative threonine allosteric regulatory site; other site 694427000463 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 694427000464 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 694427000465 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 694427000466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427000467 active site 694427000468 phosphorylation site [posttranslational modification] 694427000469 intermolecular recognition site; other site 694427000470 dimerization interface [polypeptide binding]; other site 694427000471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427000472 Walker A motif; other site 694427000473 ATP binding site [chemical binding]; other site 694427000474 Walker B motif; other site 694427000475 arginine finger; other site 694427000476 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 694427000477 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 694427000478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427000479 ATP binding site [chemical binding]; other site 694427000480 Mg2+ binding site [ion binding]; other site 694427000481 G-X-G motif; other site 694427000482 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 694427000483 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 694427000484 Walker A/P-loop; other site 694427000485 ATP binding site [chemical binding]; other site 694427000486 Q-loop/lid; other site 694427000487 ABC transporter signature motif; other site 694427000488 Walker B; other site 694427000489 D-loop; other site 694427000490 H-loop/switch region; other site 694427000491 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694427000492 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694427000493 FtsX-like permease family; Region: FtsX; pfam02687 694427000494 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694427000495 FtsX-like permease family; Region: FtsX; pfam02687 694427000496 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694427000497 FtsX-like permease family; Region: FtsX; pfam02687 694427000498 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427000499 HlyD family secretion protein; Region: HlyD_3; pfam13437 694427000500 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 694427000501 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 694427000502 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 694427000503 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 694427000504 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 694427000505 RNA binding surface [nucleotide binding]; other site 694427000506 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 694427000507 active site 694427000508 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 694427000509 nucleotide binding site [chemical binding]; other site 694427000510 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 694427000511 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 694427000512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427000513 putative substrate translocation pore; other site 694427000514 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 694427000515 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 694427000516 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 694427000517 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 694427000518 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 694427000519 active site 694427000520 nucleophile elbow; other site 694427000521 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 694427000522 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 694427000523 dimerization interface [polypeptide binding]; other site 694427000524 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 694427000525 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427000526 dimer interface [polypeptide binding]; other site 694427000527 phosphorylation site [posttranslational modification] 694427000528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427000529 ATP binding site [chemical binding]; other site 694427000530 Mg2+ binding site [ion binding]; other site 694427000531 G-X-G motif; other site 694427000532 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 694427000533 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 694427000534 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 694427000535 dimerization interface [polypeptide binding]; other site 694427000536 active site 694427000537 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 694427000538 dimer interface [polypeptide binding]; other site 694427000539 FMN binding site [chemical binding]; other site 694427000540 NADPH bind site [chemical binding]; other site 694427000541 glutamate dehydrogenase; Provisional; Region: PRK14030 694427000542 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 694427000543 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 694427000544 NAD(P) binding site [chemical binding]; other site 694427000545 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 694427000546 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 694427000547 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 694427000548 substrate binding pocket [chemical binding]; other site 694427000549 membrane-bound complex binding site; other site 694427000550 hinge residues; other site 694427000551 homoserine O-succinyltransferase; Provisional; Region: PRK05368 694427000552 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 694427000553 proposed active site lysine [active] 694427000554 conserved cys residue [active] 694427000555 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 694427000556 Peptidase family U32; Region: Peptidase_U32; pfam01136 694427000557 Collagenase; Region: DUF3656; pfam12392 694427000558 Transposase IS200 like; Region: Y1_Tnp; pfam01797 694427000559 recombinase A; Provisional; Region: recA; PRK09354 694427000560 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 694427000561 hexamer interface [polypeptide binding]; other site 694427000562 Walker A motif; other site 694427000563 ATP binding site [chemical binding]; other site 694427000564 Walker B motif; other site 694427000565 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 694427000566 Part of AAA domain; Region: AAA_19; pfam13245 694427000567 Family description; Region: UvrD_C_2; pfam13538 694427000568 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 694427000569 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 694427000570 putative acyl-acceptor binding pocket; other site 694427000571 C-N hydrolase family amidase; Provisional; Region: PRK10438 694427000572 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 694427000573 putative active site [active] 694427000574 catalytic triad [active] 694427000575 dimer interface [polypeptide binding]; other site 694427000576 multimer interface [polypeptide binding]; other site 694427000577 Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050 694427000578 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 694427000579 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 694427000580 iron binding site [ion binding]; other site 694427000581 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 694427000582 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 694427000583 minor groove reading motif; other site 694427000584 helix-hairpin-helix signature motif; other site 694427000585 substrate binding pocket [chemical binding]; other site 694427000586 active site 694427000587 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 694427000588 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 694427000589 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 694427000590 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 694427000591 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 694427000592 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 694427000593 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 694427000594 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 694427000595 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 694427000596 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 694427000597 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 694427000598 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 694427000599 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 694427000600 Ligand binding site; other site 694427000601 Putative Catalytic site; other site 694427000602 DXD motif; other site 694427000603 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 694427000604 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 694427000605 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 694427000606 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 694427000607 TPP-binding site [chemical binding]; other site 694427000608 dimer interface [polypeptide binding]; other site 694427000609 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 694427000610 PYR/PP interface [polypeptide binding]; other site 694427000611 dimer interface [polypeptide binding]; other site 694427000612 TPP binding site [chemical binding]; other site 694427000613 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 694427000614 Predicted membrane protein [Function unknown]; Region: COG1971 694427000615 Domain of unknown function DUF; Region: DUF204; pfam02659 694427000616 Domain of unknown function DUF; Region: DUF204; pfam02659 694427000617 LrgA family; Region: LrgA; pfam03788 694427000618 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 694427000619 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 694427000620 Uncharacterized conserved protein [Function unknown]; Region: COG3391 694427000621 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 694427000622 structural tetrad; other site 694427000623 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 694427000624 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 694427000625 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694427000626 motif II; other site 694427000627 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 694427000628 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694427000629 non-specific DNA binding site [nucleotide binding]; other site 694427000630 salt bridge; other site 694427000631 sequence-specific DNA binding site [nucleotide binding]; other site 694427000632 Cupin domain; Region: Cupin_2; pfam07883 694427000633 4-aminobutyrate aminotransferase; Provisional; Region: PRK06082 694427000634 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 694427000635 inhibitor-cofactor binding pocket; inhibition site 694427000636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427000637 catalytic residue [active] 694427000638 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 694427000639 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 694427000640 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694427000641 catalytic residue [active] 694427000642 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427000643 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427000644 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 694427000645 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427000646 starch binding outer membrane protein SusD; Region: SusD; cl17845 694427000647 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 694427000648 Sulfatase; Region: Sulfatase; cl17466 694427000649 Pyrococcus aspartate kinase subunit, putative; Region: AspKin_pair; TIGR02078 694427000650 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 694427000651 nucleotide binding site [chemical binding]; other site 694427000652 substrate binding site [chemical binding]; other site 694427000653 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 694427000654 recombination factor protein RarA; Reviewed; Region: PRK13342 694427000655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427000656 Walker A motif; other site 694427000657 ATP binding site [chemical binding]; other site 694427000658 Walker B motif; other site 694427000659 arginine finger; other site 694427000660 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 694427000661 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 694427000662 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 694427000663 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 694427000664 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 694427000665 Calx-beta domain; Region: Calx-beta; cl02522 694427000666 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 694427000667 active site 694427000668 catalytic residues [active] 694427000669 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427000670 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427000671 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427000672 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 694427000673 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427000674 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 694427000675 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 694427000676 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 694427000677 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 694427000678 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 694427000679 nudix motif; other site 694427000680 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 694427000681 Uncharacterized conserved protein [Function unknown]; Region: COG4095 694427000682 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 694427000683 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 694427000684 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 694427000685 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 694427000686 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 694427000687 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 694427000688 NADP binding site [chemical binding]; other site 694427000689 active site 694427000690 putative substrate binding site [chemical binding]; other site 694427000691 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 694427000692 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 694427000693 NADP-binding site; other site 694427000694 homotetramer interface [polypeptide binding]; other site 694427000695 substrate binding site [chemical binding]; other site 694427000696 homodimer interface [polypeptide binding]; other site 694427000697 active site 694427000698 Chain length determinant protein; Region: Wzz; cl15801 694427000699 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 694427000700 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 694427000701 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 694427000702 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 694427000703 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 694427000704 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 694427000705 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427000706 catalytic residues [active] 694427000707 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 694427000708 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 694427000709 minor groove reading motif; other site 694427000710 helix-hairpin-helix signature motif; other site 694427000711 substrate binding pocket [chemical binding]; other site 694427000712 active site 694427000713 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 694427000714 DNA binding and oxoG recognition site [nucleotide binding] 694427000715 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 694427000716 IHF - DNA interface [nucleotide binding]; other site 694427000717 IHF dimer interface [polypeptide binding]; other site 694427000718 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 694427000719 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 694427000720 homodimer interface [polypeptide binding]; other site 694427000721 oligonucleotide binding site [chemical binding]; other site 694427000722 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 694427000723 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 694427000724 RNA binding site [nucleotide binding]; other site 694427000725 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 694427000726 RNA binding site [nucleotide binding]; other site 694427000727 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 694427000728 RNA binding site [nucleotide binding]; other site 694427000729 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 694427000730 RNA binding site [nucleotide binding]; other site 694427000731 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 694427000732 RNA binding site [nucleotide binding]; other site 694427000733 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 694427000734 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501 694427000735 active site 694427000736 catalytic triad [active] 694427000737 oxyanion hole [active] 694427000738 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 694427000739 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 694427000740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427000741 putative substrate translocation pore; other site 694427000742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427000743 putative substrate translocation pore; other site 694427000744 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 694427000745 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 694427000746 HlyD family secretion protein; Region: HlyD_3; pfam13437 694427000747 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 694427000748 MarR family; Region: MarR; pfam01047 694427000749 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 694427000750 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 694427000751 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 694427000752 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 694427000753 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 694427000754 active site 694427000755 dimer interface [polypeptide binding]; other site 694427000756 motif 1; other site 694427000757 motif 2; other site 694427000758 motif 3; other site 694427000759 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 694427000760 anticodon binding site; other site 694427000761 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 694427000762 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427000763 putative catalytic residue [active] 694427000764 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427000765 catalytic residues [active] 694427000766 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 694427000767 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 694427000768 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 694427000769 RNA binding surface [nucleotide binding]; other site 694427000770 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 694427000771 active site 694427000772 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 694427000773 TIGR01777 family protein; Region: yfcH 694427000774 putative NAD(P) binding site [chemical binding]; other site 694427000775 putative active site [active] 694427000776 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427000777 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427000778 LytTr DNA-binding domain; Region: LytTR; smart00850 694427000779 Methyltransferase domain; Region: Methyltransf_31; pfam13847 694427000780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427000781 S-adenosylmethionine binding site [chemical binding]; other site 694427000782 GGGtGRT protein; Region: GGGtGRT; pfam14057 694427000783 hypothetical protein; Reviewed; Region: PRK12275 694427000784 four helix bundle protein; Region: TIGR02436 694427000785 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 694427000786 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 694427000787 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 694427000788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427000789 Coenzyme A binding pocket [chemical binding]; other site 694427000790 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 694427000791 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 694427000792 metal binding site [ion binding]; metal-binding site 694427000793 dimer interface [polypeptide binding]; other site 694427000794 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 694427000795 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 694427000796 membrane ATPase/protein kinase; Provisional; Region: PRK09435 694427000797 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 694427000798 Walker A; other site 694427000799 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 694427000800 DNA methylase; Region: N6_N4_Mtase; pfam01555 694427000801 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 694427000802 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 694427000803 dimer interface [polypeptide binding]; other site 694427000804 active site 694427000805 CoA binding pocket [chemical binding]; other site 694427000806 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 694427000807 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 694427000808 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 694427000809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427000810 ATP binding site [chemical binding]; other site 694427000811 Mg2+ binding site [ion binding]; other site 694427000812 G-X-G motif; other site 694427000813 GTPase Era; Reviewed; Region: era; PRK00089 694427000814 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 694427000815 G1 box; other site 694427000816 GTP/Mg2+ binding site [chemical binding]; other site 694427000817 Switch I region; other site 694427000818 G2 box; other site 694427000819 Switch II region; other site 694427000820 G3 box; other site 694427000821 G4 box; other site 694427000822 G5 box; other site 694427000823 KH domain; Region: KH_2; pfam07650 694427000824 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 694427000825 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 694427000826 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 694427000827 ribonuclease Z; Region: RNase_Z; TIGR02651 694427000828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 694427000829 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 694427000830 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 694427000831 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 694427000832 Walker A/P-loop; other site 694427000833 ATP binding site [chemical binding]; other site 694427000834 Q-loop/lid; other site 694427000835 ABC transporter signature motif; other site 694427000836 Walker B; other site 694427000837 D-loop; other site 694427000838 H-loop/switch region; other site 694427000839 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 694427000840 2-amino-3-ketobutyrate coenzyme A ligase; Provisional; Region: PRK06939 694427000841 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 694427000842 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694427000843 catalytic residue [active] 694427000844 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 694427000845 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 694427000846 NAD(P) binding site [chemical binding]; other site 694427000847 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 694427000848 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 694427000849 ATP binding site [chemical binding]; other site 694427000850 Mg++ binding site [ion binding]; other site 694427000851 motif III; other site 694427000852 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427000853 nucleotide binding region [chemical binding]; other site 694427000854 ATP-binding site [chemical binding]; other site 694427000855 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 694427000856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427000857 NADH(P)-binding; Region: NAD_binding_10; pfam13460 694427000858 NAD(P) binding site [chemical binding]; other site 694427000859 active site 694427000860 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 694427000861 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 694427000862 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 694427000863 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 694427000864 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 694427000865 trimer interface [polypeptide binding]; other site 694427000866 active site 694427000867 substrate binding site [chemical binding]; other site 694427000868 CoA binding site [chemical binding]; other site 694427000869 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 694427000870 putative ligand binding site [chemical binding]; other site 694427000871 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 694427000872 Cation efflux family; Region: Cation_efflux; cl00316 694427000873 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 694427000874 Ligand binding site [chemical binding]; other site 694427000875 Electron transfer flavoprotein domain; Region: ETF; pfam01012 694427000876 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 694427000877 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 694427000878 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 694427000879 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 694427000880 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 694427000881 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 694427000882 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 694427000883 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 694427000884 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 694427000885 ATP binding site [chemical binding]; other site 694427000886 Mg++ binding site [ion binding]; other site 694427000887 motif III; other site 694427000888 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427000889 nucleotide binding region [chemical binding]; other site 694427000890 ATP-binding site [chemical binding]; other site 694427000891 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 694427000892 Helix-turn-helix domain; Region: HTH_18; pfam12833 694427000893 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427000894 Pirin-related protein [General function prediction only]; Region: COG1741 694427000895 Pirin; Region: Pirin; pfam02678 694427000896 DoxX; Region: DoxX; pfam07681 694427000897 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 694427000898 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 694427000899 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 694427000900 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 694427000901 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 694427000902 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 694427000903 Protein of unknown function (DUF423); Region: DUF423; pfam04241 694427000904 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 694427000905 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 694427000906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427000907 Walker A/P-loop; other site 694427000908 ATP binding site [chemical binding]; other site 694427000909 Q-loop/lid; other site 694427000910 ABC transporter signature motif; other site 694427000911 Walker B; other site 694427000912 D-loop; other site 694427000913 H-loop/switch region; other site 694427000914 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 694427000915 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 694427000916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427000917 Walker A/P-loop; other site 694427000918 ATP binding site [chemical binding]; other site 694427000919 Q-loop/lid; other site 694427000920 ABC transporter signature motif; other site 694427000921 Walker B; other site 694427000922 D-loop; other site 694427000923 H-loop/switch region; other site 694427000924 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 694427000925 dimer interface [polypeptide binding]; other site 694427000926 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 694427000927 putative hydrophobic ligand binding site [chemical binding]; other site 694427000928 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 694427000929 dimer interface [polypeptide binding]; other site 694427000930 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 694427000931 Predicted transcriptional regulators [Transcription]; Region: COG1733 694427000932 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 694427000933 short chain dehydrogenase; Provisional; Region: PRK06523 694427000934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427000935 NAD(P) binding site [chemical binding]; other site 694427000936 active site 694427000937 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 694427000938 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 694427000939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 694427000940 intermolecular recognition site; other site 694427000941 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 694427000942 Probable beta-xylosidase; Provisional; Region: PLN03080 694427000943 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 694427000944 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 694427000945 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 694427000946 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 694427000947 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 694427000948 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 694427000949 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 694427000950 NlpC/P60 family; Region: NLPC_P60; pfam00877 694427000951 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 694427000952 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427000953 GLPGLI family protein; Region: GLPGLI; TIGR01200 694427000954 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 694427000955 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427000956 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427000957 catalytic residues [active] 694427000958 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 694427000959 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 694427000960 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 694427000961 Penicillinase repressor; Region: Pencillinase_R; pfam03965 694427000962 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 694427000963 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 694427000964 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 694427000965 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 694427000966 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 694427000967 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 694427000968 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 694427000969 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 694427000970 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 694427000971 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 694427000972 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 694427000973 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 694427000974 proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974 694427000975 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 694427000976 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 694427000977 NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008 694427000978 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 694427000979 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 694427000980 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 694427000981 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 694427000982 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 694427000983 putative active site [active] 694427000984 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 694427000985 Protein of unknown function (DUF454); Region: DUF454; cl01063 694427000986 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 694427000987 homodimer interface [polypeptide binding]; other site 694427000988 putative GKAP docking site [polypeptide binding]; other site 694427000989 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 694427000990 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 694427000991 Sensory domain found in PocR; Region: PocR; pfam10114 694427000992 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 694427000993 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 694427000994 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 694427000995 putative active site [active] 694427000996 heme pocket [chemical binding]; other site 694427000997 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 694427000998 PAS domain S-box; Region: sensory_box; TIGR00229 694427000999 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427001000 putative active site [active] 694427001001 heme pocket [chemical binding]; other site 694427001002 PAS fold; Region: PAS_3; pfam08447 694427001003 PAS domain S-box; Region: sensory_box; TIGR00229 694427001004 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427001005 putative active site [active] 694427001006 heme pocket [chemical binding]; other site 694427001007 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 694427001008 Histidine kinase; Region: HisKA_3; pfam07730 694427001009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427001010 ATP binding site [chemical binding]; other site 694427001011 Mg2+ binding site [ion binding]; other site 694427001012 G-X-G motif; other site 694427001013 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 694427001014 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 694427001015 dimer interface [polypeptide binding]; other site 694427001016 PYR/PP interface [polypeptide binding]; other site 694427001017 TPP binding site [chemical binding]; other site 694427001018 substrate binding site [chemical binding]; other site 694427001019 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 694427001020 Domain of unknown function; Region: EKR; smart00890 694427001021 4Fe-4S binding domain; Region: Fer4_6; pfam12837 694427001022 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 694427001023 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 694427001024 TPP-binding site [chemical binding]; other site 694427001025 dimer interface [polypeptide binding]; other site 694427001026 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 694427001027 AAA domain; Region: AAA_14; pfam13173 694427001028 CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655 694427001029 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 694427001030 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 694427001031 Beta-Casp domain; Region: Beta-Casp; smart01027 694427001032 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 694427001033 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 694427001034 Glycoprotease family; Region: Peptidase_M22; pfam00814 694427001035 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 694427001036 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 694427001037 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 694427001038 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 694427001039 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 694427001040 ligand binding site [chemical binding]; other site 694427001041 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 694427001042 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 694427001043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427001044 S-adenosylmethionine binding site [chemical binding]; other site 694427001045 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 694427001046 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 694427001047 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 694427001048 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427001049 nucleotide binding region [chemical binding]; other site 694427001050 ATP-binding site [chemical binding]; other site 694427001051 SEC-C motif; Region: SEC-C; pfam02810 694427001052 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 694427001053 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 694427001054 NAD(P) binding site [chemical binding]; other site 694427001055 homotetramer interface [polypeptide binding]; other site 694427001056 homodimer interface [polypeptide binding]; other site 694427001057 active site 694427001058 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 694427001059 transcription termination factor Rho; Provisional; Region: rho; PRK09376 694427001060 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 694427001061 RNA binding site [nucleotide binding]; other site 694427001062 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 694427001063 multimer interface [polypeptide binding]; other site 694427001064 Walker A motif; other site 694427001065 ATP binding site [chemical binding]; other site 694427001066 Walker B motif; other site 694427001067 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 694427001068 MgtC family; Region: MgtC; pfam02308 694427001069 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 694427001070 MarR family; Region: MarR_2; pfam12802 694427001071 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427001072 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 694427001073 HlyD family secretion protein; Region: HlyD_3; pfam13437 694427001074 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 694427001075 Protein export membrane protein; Region: SecD_SecF; cl14618 694427001076 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 694427001077 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 694427001078 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 694427001079 carboxyltransferase (CT) interaction site; other site 694427001080 biotinylation site [posttranslational modification]; other site 694427001081 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 694427001082 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 694427001083 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 694427001084 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 694427001085 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 694427001086 dimer interface [polypeptide binding]; other site 694427001087 substrate binding site [chemical binding]; other site 694427001088 metal binding site [ion binding]; metal-binding site 694427001089 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 694427001090 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 694427001091 Predicted transcriptional regulator [Transcription]; Region: COG2932 694427001092 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 694427001093 Catalytic site [active] 694427001094 Transcription antiterminator [Transcription]; Region: NusG; COG0250 694427001095 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 694427001096 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 694427001097 SLBB domain; Region: SLBB; pfam10531 694427001098 Chain length determinant protein; Region: Wzz; cl15801 694427001099 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 694427001100 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 694427001101 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 694427001102 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 694427001103 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 694427001104 trimer interface [polypeptide binding]; other site 694427001105 active site 694427001106 substrate binding site [chemical binding]; other site 694427001107 CoA binding site [chemical binding]; other site 694427001108 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 694427001109 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 694427001110 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 694427001111 putative ligand binding site [chemical binding]; other site 694427001112 putative catalytic site [active] 694427001113 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427001114 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 694427001115 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 694427001116 FMN binding site [chemical binding]; other site 694427001117 dimer interface [polypeptide binding]; other site 694427001118 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 694427001119 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427001120 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 694427001121 putative ADP-binding pocket [chemical binding]; other site 694427001122 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694427001123 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 694427001124 Probable Catalytic site; other site 694427001125 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427001126 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 694427001127 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 694427001128 substrate binding site; other site 694427001129 tetramer interface; other site 694427001130 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 694427001131 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 694427001132 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 694427001133 NADP binding site [chemical binding]; other site 694427001134 active site 694427001135 putative substrate binding site [chemical binding]; other site 694427001136 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 694427001137 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 694427001138 NAD binding site [chemical binding]; other site 694427001139 substrate binding site [chemical binding]; other site 694427001140 homodimer interface [polypeptide binding]; other site 694427001141 active site 694427001142 putative acyl transferase; Provisional; Region: PRK10502 694427001143 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 694427001144 active site 694427001145 substrate binding site [chemical binding]; other site 694427001146 trimer interface [polypeptide binding]; other site 694427001147 CoA binding site [chemical binding]; other site 694427001148 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 694427001149 Bacterial sugar transferase; Region: Bac_transf; pfam02397 694427001150 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 694427001151 non-specific DNA binding site [nucleotide binding]; other site 694427001152 salt bridge; other site 694427001153 sequence-specific DNA binding site [nucleotide binding]; other site 694427001154 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 694427001155 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 694427001156 putative active site [active] 694427001157 putative metal binding site [ion binding]; other site 694427001158 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 694427001159 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 694427001160 trmE is a tRNA modification GTPase; Region: trmE; cd04164 694427001161 G1 box; other site 694427001162 GTP/Mg2+ binding site [chemical binding]; other site 694427001163 Switch I region; other site 694427001164 G2 box; other site 694427001165 Switch II region; other site 694427001166 G3 box; other site 694427001167 G4 box; other site 694427001168 G5 box; other site 694427001169 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 694427001170 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 694427001171 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 694427001172 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 694427001173 catalytic center binding site [active] 694427001174 ATP binding site [chemical binding]; other site 694427001175 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 694427001176 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427001177 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427001178 DNA binding residues [nucleotide binding] 694427001179 lipoyl synthase; Provisional; Region: PRK05481 694427001180 Helix-turn-helix domain; Region: HTH_18; pfam12833 694427001181 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427001182 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 694427001183 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 694427001184 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 694427001185 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 694427001186 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 694427001187 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 694427001188 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 694427001189 Domain of unknown function (DUF4294); Region: DUF4294; pfam14127 694427001190 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 694427001191 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 694427001192 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 694427001193 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427001194 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427001195 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 694427001196 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 694427001197 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 694427001198 starch binding outer membrane protein SusD; Region: SusD; cl17845 694427001199 SusD family; Region: SusD; pfam07980 694427001200 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427001201 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427001202 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 694427001203 starch binding outer membrane protein SusD; Region: SusD; cl17845 694427001204 SusD family; Region: SusD; pfam07980 694427001205 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 694427001206 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 694427001207 substrate binding site [chemical binding]; other site 694427001208 active site 694427001209 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 694427001210 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 694427001211 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 694427001212 mannonate dehydratase; Provisional; Region: PRK03906 694427001213 mannonate dehydratase; Region: uxuA; TIGR00695 694427001214 D-mannonate oxidoreductase; Provisional; Region: PRK08277 694427001215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427001216 NAD(P) binding site [chemical binding]; other site 694427001217 active site 694427001218 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 694427001219 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 694427001220 ligand binding site [chemical binding]; other site 694427001221 flexible hinge region; other site 694427001222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427001223 Coenzyme A binding pocket [chemical binding]; other site 694427001224 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 694427001225 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427001226 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427001227 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 694427001228 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 694427001229 Beta-lactamase; Region: Beta-lactamase; pfam00144 694427001230 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 694427001231 Histidine kinase; Region: His_kinase; pfam06580 694427001232 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 694427001233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427001234 active site 694427001235 phosphorylation site [posttranslational modification] 694427001236 intermolecular recognition site; other site 694427001237 dimerization interface [polypeptide binding]; other site 694427001238 LytTr DNA-binding domain; Region: LytTR; smart00850 694427001239 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 694427001240 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 694427001241 Fibronectin type 3 domain; Region: FN3; smart00060 694427001242 Interdomain contacts; other site 694427001243 Cytokine receptor motif; other site 694427001244 HEPN domain; Region: HEPN; cl00824 694427001245 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 694427001246 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 694427001247 hydrophobic ligand binding site; other site 694427001248 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 694427001249 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 694427001250 N-terminal plug; other site 694427001251 ligand-binding site [chemical binding]; other site 694427001252 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 694427001253 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 694427001254 Uncharacterized conserved protein [Function unknown]; Region: COG1284 694427001255 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 694427001256 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427001257 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427001258 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427001259 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 694427001260 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427001261 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 694427001262 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 694427001263 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 694427001264 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 694427001265 Uncharacterized conserved protein [Function unknown]; Region: COG3391 694427001266 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 694427001267 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 694427001268 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 694427001269 proposed catalytic triad [active] 694427001270 active site nucleophile [active] 694427001271 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 694427001272 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 694427001273 isoaspartyl dipeptidase; Provisional; Region: PRK10657 694427001274 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 694427001275 active site 694427001276 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 694427001277 active site 694427001278 Zn binding site [ion binding]; other site 694427001279 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 694427001280 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 694427001281 active site 694427001282 octamer interface [polypeptide binding]; other site 694427001283 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 694427001284 L-lysine aminotransferase; Provisional; Region: PRK08297 694427001285 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694427001286 catalytic residue [active] 694427001287 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 694427001288 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 694427001289 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 694427001290 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 694427001291 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 694427001292 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 694427001293 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 694427001294 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 694427001295 Chloramphenicol acetyltransferase; Region: CAT; smart01059 694427001296 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 694427001297 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 694427001298 dimer interface [polypeptide binding]; other site 694427001299 active site 694427001300 glycine-pyridoxal phosphate binding site [chemical binding]; other site 694427001301 folate binding site [chemical binding]; other site 694427001302 four helix bundle protein; Region: TIGR02436 694427001303 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 694427001304 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 694427001305 PhoH-like protein; Region: PhoH; pfam02562 694427001306 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 694427001307 ATP binding site [chemical binding]; other site 694427001308 active site 694427001309 substrate binding site [chemical binding]; other site 694427001310 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 694427001311 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 694427001312 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 694427001313 intersubunit interface [polypeptide binding]; other site 694427001314 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427001315 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427001316 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 694427001317 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 694427001318 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 694427001319 metal-binding site [ion binding] 694427001320 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 694427001321 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 694427001322 intersubunit interface [polypeptide binding]; other site 694427001323 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427001324 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 694427001325 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427001326 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 694427001327 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 694427001328 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427001329 Walker A/P-loop; other site 694427001330 ATP binding site [chemical binding]; other site 694427001331 Q-loop/lid; other site 694427001332 ABC transporter signature motif; other site 694427001333 Walker B; other site 694427001334 D-loop; other site 694427001335 H-loop/switch region; other site 694427001336 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 694427001337 homodimer interaction site [polypeptide binding]; other site 694427001338 cofactor binding site; other site 694427001339 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 694427001340 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 694427001341 ABC-ATPase subunit interface; other site 694427001342 dimer interface [polypeptide binding]; other site 694427001343 putative PBP binding regions; other site 694427001344 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 694427001345 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 694427001346 Walker A/P-loop; other site 694427001347 ATP binding site [chemical binding]; other site 694427001348 Q-loop/lid; other site 694427001349 ABC transporter signature motif; other site 694427001350 Walker B; other site 694427001351 D-loop; other site 694427001352 H-loop/switch region; other site 694427001353 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427001354 AAA ATPase domain; Region: AAA_15; pfam13175 694427001355 Walker A/P-loop; other site 694427001356 ATP binding site [chemical binding]; other site 694427001357 Transposase IS200 like; Region: Y1_Tnp; cl00848 694427001358 PAS domain S-box; Region: sensory_box; TIGR00229 694427001359 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427001360 putative active site [active] 694427001361 heme pocket [chemical binding]; other site 694427001362 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 694427001363 active site 694427001364 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 694427001365 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 694427001366 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 694427001367 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 694427001368 catalytic site [active] 694427001369 subunit interface [polypeptide binding]; other site 694427001370 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 694427001371 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 694427001372 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 694427001373 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 694427001374 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 694427001375 ATP-grasp domain; Region: ATP-grasp_4; cl17255 694427001376 Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain; Region: MGS_CPS_I_III; cd01423 694427001377 probable substrate binding site [chemical binding]; other site 694427001378 K+ potassium transporter; Region: K_trans; pfam02705 694427001379 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 694427001380 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 694427001381 G1 box; other site 694427001382 putative GEF interaction site [polypeptide binding]; other site 694427001383 GTP/Mg2+ binding site [chemical binding]; other site 694427001384 Switch I region; other site 694427001385 G2 box; other site 694427001386 G3 box; other site 694427001387 Switch II region; other site 694427001388 G4 box; other site 694427001389 G5 box; other site 694427001390 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 694427001391 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 694427001392 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 694427001393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 694427001394 S-adenosylmethionine binding site [chemical binding]; other site 694427001395 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 694427001396 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 694427001397 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 694427001398 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 694427001399 TPP-binding site [chemical binding]; other site 694427001400 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 694427001401 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 694427001402 dimer interface [polypeptide binding]; other site 694427001403 PYR/PP interface [polypeptide binding]; other site 694427001404 TPP binding site [chemical binding]; other site 694427001405 substrate binding site [chemical binding]; other site 694427001406 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 694427001407 Ferredoxin [Energy production and conversion]; Region: COG1146 694427001408 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 694427001409 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 694427001410 putative active site [active] 694427001411 putative metal binding residues [ion binding]; other site 694427001412 signature motif; other site 694427001413 putative dimer interface [polypeptide binding]; other site 694427001414 putative phosphate binding site [ion binding]; other site 694427001415 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 694427001416 Protein of unknown function (DUF554); Region: DUF554; pfam04474 694427001417 Peptidase family M48; Region: Peptidase_M48; cl12018 694427001418 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 694427001419 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 694427001420 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 694427001421 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 694427001422 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 694427001423 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 694427001424 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 694427001425 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 694427001426 carboxyltransferase (CT) interaction site; other site 694427001427 biotinylation site [posttranslational modification]; other site 694427001428 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 694427001429 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 694427001430 active site 694427001431 metal binding site [ion binding]; metal-binding site 694427001432 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 694427001433 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 694427001434 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 694427001435 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 694427001436 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 694427001437 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 694427001438 active site 694427001439 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 694427001440 dimer interface [polypeptide binding]; other site 694427001441 substrate binding site [chemical binding]; other site 694427001442 catalytic residues [active] 694427001443 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 694427001444 Ligand Binding Site [chemical binding]; other site 694427001445 Ion channel; Region: Ion_trans_2; pfam07885 694427001446 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 694427001447 TrkA-N domain; Region: TrkA_N; pfam02254 694427001448 TrkA-C domain; Region: TrkA_C; pfam02080 694427001449 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 694427001450 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 694427001451 NAD binding site [chemical binding]; other site 694427001452 ATP-grasp domain; Region: ATP-grasp; pfam02222 694427001453 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 694427001454 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694427001455 DNA binding site [nucleotide binding] 694427001456 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 694427001457 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 694427001458 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 694427001459 active site 694427001460 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 694427001461 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427001462 FeS/SAM binding site; other site 694427001463 Maf-like protein; Region: Maf; pfam02545 694427001464 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 694427001465 active site 694427001466 dimer interface [polypeptide binding]; other site 694427001467 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 694427001468 UbiA prenyltransferase family; Region: UbiA; pfam01040 694427001469 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 694427001470 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 694427001471 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 694427001472 FMN binding site [chemical binding]; other site 694427001473 dimer interface [polypeptide binding]; other site 694427001474 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 694427001475 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 694427001476 Outer membrane efflux protein; Region: OEP; pfam02321 694427001477 Outer membrane efflux protein; Region: OEP; pfam02321 694427001478 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427001479 HlyD family secretion protein; Region: HlyD_3; pfam13437 694427001480 hypothetical protein; Provisional; Region: PRK02237 694427001481 GSCFA family; Region: GSCFA; pfam08885 694427001482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427001483 D-galactonate transporter; Region: 2A0114; TIGR00893 694427001484 putative substrate translocation pore; other site 694427001485 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 694427001486 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 694427001487 active site 694427001488 intersubunit interface [polypeptide binding]; other site 694427001489 catalytic residue [active] 694427001490 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 694427001491 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 694427001492 substrate binding site [chemical binding]; other site 694427001493 ATP binding site [chemical binding]; other site 694427001494 glucuronate isomerase; Reviewed; Region: PRK02925 694427001495 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 694427001496 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 694427001497 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694427001498 DNA binding site [nucleotide binding] 694427001499 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 694427001500 DNA binding site [nucleotide binding] 694427001501 domain linker motif; other site 694427001502 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 694427001503 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 694427001504 ligand binding site [chemical binding]; other site 694427001505 D-mannonate oxidoreductase; Provisional; Region: PRK08277 694427001506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427001507 NAD(P) binding site [chemical binding]; other site 694427001508 active site 694427001509 mannonate dehydratase; Provisional; Region: PRK03906 694427001510 mannonate dehydratase; Region: uxuA; TIGR00695 694427001511 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 694427001512 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 694427001513 ligand binding site [chemical binding]; other site 694427001514 NAD binding site [chemical binding]; other site 694427001515 catalytic site [active] 694427001516 homodimer interface [polypeptide binding]; other site 694427001517 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 694427001518 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 694427001519 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 694427001520 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 694427001521 LytTr DNA-binding domain; Region: LytTR; cl04498 694427001522 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 694427001523 HerA helicase [Replication, recombination, and repair]; Region: COG0433 694427001524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 694427001525 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 694427001526 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 694427001527 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 694427001528 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 694427001529 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 694427001530 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 694427001531 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427001532 catalytic residues [active] 694427001533 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 694427001534 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 694427001535 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 694427001536 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 694427001537 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 694427001538 putative deacylase active site [active] 694427001539 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 694427001540 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 694427001541 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 694427001542 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 694427001543 tetramer interface [polypeptide binding]; other site 694427001544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427001545 catalytic residue [active] 694427001546 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 694427001547 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 694427001548 active site 694427001549 transcription antitermination factor NusB; Region: nusB; TIGR01951 694427001550 Preprotein translocase subunit; Region: YajC; pfam02699 694427001551 YbbR-like protein; Region: YbbR; pfam07949 694427001552 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 694427001553 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 694427001554 inhibitor-cofactor binding pocket; inhibition site 694427001555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427001556 catalytic residue [active] 694427001557 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 694427001558 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 694427001559 putative trimer interface [polypeptide binding]; other site 694427001560 putative active site [active] 694427001561 putative substrate binding site [chemical binding]; other site 694427001562 putative CoA binding site [chemical binding]; other site 694427001563 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 694427001564 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 694427001565 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 694427001566 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 694427001567 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 694427001568 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 694427001569 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 694427001570 TraB family; Region: TraB; pfam01963 694427001571 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 694427001572 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 694427001573 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 694427001574 dimerization interface [polypeptide binding]; other site 694427001575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427001576 TPR motif; other site 694427001577 binding surface 694427001578 TPR repeat; Region: TPR_11; pfam13414 694427001579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427001580 TPR motif; other site 694427001581 binding surface 694427001582 TPR repeat; Region: TPR_11; pfam13414 694427001583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427001584 binding surface 694427001585 TPR motif; other site 694427001586 Tetratricopeptide repeat; Region: TPR_9; pfam13371 694427001587 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427001588 binding surface 694427001589 TPR motif; other site 694427001590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427001591 binding surface 694427001592 TPR motif; other site 694427001593 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427001594 TPR motif; other site 694427001595 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427001596 binding surface 694427001597 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 694427001598 Transglycosylase; Region: Transgly; pfam00912 694427001599 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 694427001600 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 694427001601 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427001602 FeS/SAM binding site; other site 694427001603 HemN C-terminal domain; Region: HemN_C; pfam06969 694427001604 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 694427001605 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 694427001606 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 694427001607 putative acyl-acceptor binding pocket; other site 694427001608 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 694427001609 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 694427001610 Probable Catalytic site; other site 694427001611 metal-binding site 694427001612 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 694427001613 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 694427001614 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 694427001615 active site 694427001616 dimer interface [polypeptide binding]; other site 694427001617 effector binding site; other site 694427001618 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 694427001619 TSCPD domain; Region: TSCPD; cl14834 694427001620 recombination protein F; Reviewed; Region: recF; PRK00064 694427001621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427001622 Walker A/P-loop; other site 694427001623 ATP binding site [chemical binding]; other site 694427001624 Q-loop/lid; other site 694427001625 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427001626 ABC transporter signature motif; other site 694427001627 Walker B; other site 694427001628 D-loop; other site 694427001629 H-loop/switch region; other site 694427001630 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 694427001631 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 694427001632 Malic enzyme, N-terminal domain; Region: malic; pfam00390 694427001633 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 694427001634 putative NAD(P) binding site [chemical binding]; other site 694427001635 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 694427001636 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 694427001637 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 694427001638 peptidase T; Region: peptidase-T; TIGR01882 694427001639 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 694427001640 metal binding site [ion binding]; metal-binding site 694427001641 dimer interface [polypeptide binding]; other site 694427001642 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 694427001643 putative active site [active] 694427001644 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 694427001645 hypothetical protein; Provisional; Region: PRK00955 694427001646 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 694427001647 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 694427001648 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427001649 FeS/SAM binding site; other site 694427001650 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 694427001651 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 694427001652 catalytic residues [active] 694427001653 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 694427001654 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 694427001655 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 694427001656 Ligand binding site; other site 694427001657 Putative Catalytic site; other site 694427001658 DXD motif; other site 694427001659 Predicted membrane protein [Function unknown]; Region: COG2246 694427001660 GtrA-like protein; Region: GtrA; pfam04138 694427001661 AAA domain; Region: AAA_22; pfam13401 694427001662 AAA domain; Region: AAA_30; pfam13604 694427001663 Family description; Region: UvrD_C_2; pfam13538 694427001664 HRDC domain; Region: HRDC; pfam00570 694427001665 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 694427001666 DoxX-like family; Region: DoxX_2; pfam13564 694427001667 RibD C-terminal domain; Region: RibD_C; cl17279 694427001668 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 694427001669 RibD C-terminal domain; Region: RibD_C; cl17279 694427001670 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 694427001671 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14466 694427001672 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427001673 FeS/SAM binding site; other site 694427001674 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 694427001675 FMN reductase; Validated; Region: fre; PRK08051 694427001676 FAD binding pocket [chemical binding]; other site 694427001677 conserved FAD binding motif [chemical binding]; other site 694427001678 phosphate binding motif [ion binding]; other site 694427001679 beta-alpha-beta structure motif; other site 694427001680 NAD binding pocket [chemical binding]; other site 694427001681 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 694427001682 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 694427001683 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 694427001684 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 694427001685 Ligand Binding Site [chemical binding]; other site 694427001686 TilS substrate C-terminal domain; Region: TilS_C; smart00977 694427001687 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 694427001688 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 694427001689 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 694427001690 active site 694427001691 catalytic residues [active] 694427001692 metal binding site [ion binding]; metal-binding site 694427001693 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 694427001694 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 694427001695 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 694427001696 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 694427001697 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 694427001698 catalytic residue [active] 694427001699 Peptidase family M48; Region: Peptidase_M48; pfam01435 694427001700 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 694427001701 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 694427001702 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 694427001703 Active site serine [active] 694427001704 CAAX protease self-immunity; Region: Abi; pfam02517 694427001705 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 694427001706 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 694427001707 Walker A/P-loop; other site 694427001708 ATP binding site [chemical binding]; other site 694427001709 Q-loop/lid; other site 694427001710 ABC transporter signature motif; other site 694427001711 Walker B; other site 694427001712 D-loop; other site 694427001713 H-loop/switch region; other site 694427001714 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427001715 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 694427001716 Coenzyme A binding pocket [chemical binding]; other site 694427001717 Transposase IS200 like; Region: Y1_Tnp; pfam01797 694427001718 Part of AAA domain; Region: AAA_19; pfam13245 694427001719 AAA domain; Region: AAA_11; pfam13086 694427001720 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 694427001721 AAA domain; Region: AAA_12; pfam13087 694427001722 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 694427001723 putative active site [active] 694427001724 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 694427001725 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 694427001726 DNA binding residues [nucleotide binding] 694427001727 dimerization interface [polypeptide binding]; other site 694427001728 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 694427001729 Domain of unknown function (DUF303); Region: DUF303; pfam03629 694427001730 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 694427001731 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 694427001732 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 694427001733 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 694427001734 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 694427001735 active site 694427001736 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 694427001737 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 694427001738 active site 694427001739 catalytic triad [active] 694427001740 oxyanion hole [active] 694427001741 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 694427001742 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 694427001743 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 694427001744 putative acyl-acceptor binding pocket; other site 694427001745 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 694427001746 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 694427001747 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 694427001748 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 694427001749 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 694427001750 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694427001751 catalytic residue [active] 694427001752 hypothetical protein; Provisional; Region: PRK11820 694427001753 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 694427001754 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 694427001755 Guanylate kinase; Region: Guanylate_kin; pfam00625 694427001756 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 694427001757 catalytic site [active] 694427001758 G-X2-G-X-G-K; other site 694427001759 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 694427001760 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 694427001761 active site 694427001762 (T/H)XGH motif; other site 694427001763 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 694427001764 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 694427001765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427001766 S-adenosylmethionine binding site [chemical binding]; other site 694427001767 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 694427001768 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 694427001769 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 694427001770 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 694427001771 dimer interface [polypeptide binding]; other site 694427001772 anticodon binding site; other site 694427001773 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 694427001774 homodimer interface [polypeptide binding]; other site 694427001775 motif 1; other site 694427001776 active site 694427001777 motif 2; other site 694427001778 GAD domain; Region: GAD; pfam02938 694427001779 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 694427001780 motif 3; other site 694427001781 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 694427001782 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 694427001783 PhnA protein; Region: PhnA; pfam03831 694427001784 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 694427001785 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427001786 Coenzyme A binding pocket [chemical binding]; other site 694427001787 Helix-turn-helix domain; Region: HTH_18; pfam12833 694427001788 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 694427001789 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 694427001790 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 694427001791 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 694427001792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427001793 putative substrate translocation pore; other site 694427001794 xylose isomerase; Provisional; Region: PRK05474 694427001795 xylose isomerase; Region: xylose_isom_A; TIGR02630 694427001796 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 694427001797 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 694427001798 nucleotide binding site [chemical binding]; other site 694427001799 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 694427001800 nudix motif; other site 694427001801 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 694427001802 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 694427001803 active site 694427001804 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 694427001805 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 694427001806 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 694427001807 uracil transporter; Provisional; Region: PRK10720 694427001808 EamA-like transporter family; Region: EamA; cl17759 694427001809 EamA-like transporter family; Region: EamA; pfam00892 694427001810 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 694427001811 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 694427001812 Homeodomain-like domain; Region: HTH_23; cl17451 694427001813 acyl transferase; Provisional; Region: luxD; PRK13604 694427001814 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 694427001815 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 694427001816 prolyl-tRNA synthetase; Provisional; Region: PRK08661 694427001817 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 694427001818 dimer interface [polypeptide binding]; other site 694427001819 motif 1; other site 694427001820 active site 694427001821 motif 2; other site 694427001822 motif 3; other site 694427001823 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 694427001824 anticodon binding site; other site 694427001825 zinc-binding site [ion binding]; other site 694427001826 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 694427001827 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 694427001828 putative active site [active] 694427001829 putative metal binding site [ion binding]; other site 694427001830 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 694427001831 Bacterial SH3 domain; Region: SH3_3; pfam08239 694427001832 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427001833 CAAX protease self-immunity; Region: Abi; pfam02517 694427001834 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 694427001835 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 694427001836 CUB-like domain; Region: CUB_2; pfam02408 694427001837 CUB-like domain; Region: CUB_2; pfam02408 694427001838 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 694427001839 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 694427001840 active site 694427001841 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 694427001842 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 694427001843 conserved cys residue [active] 694427001844 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 694427001845 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 694427001846 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 694427001847 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 694427001848 RNA binding site [nucleotide binding]; other site 694427001849 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 694427001850 DNA polymerase III, delta subunit; Region: holA; TIGR01128 694427001851 AMP nucleosidase; Provisional; Region: PRK07115 694427001852 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 694427001853 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 694427001854 A new structural DNA glycosylase; Region: AlkD_like; cd06561 694427001855 active site 694427001856 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 694427001857 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 694427001858 putative active site [active] 694427001859 putative metal binding site [ion binding]; other site 694427001860 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 694427001861 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 694427001862 heterodimer interface [polypeptide binding]; other site 694427001863 active site 694427001864 FMN binding site [chemical binding]; other site 694427001865 homodimer interface [polypeptide binding]; other site 694427001866 substrate binding site [chemical binding]; other site 694427001867 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 694427001868 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 694427001869 FAD binding pocket [chemical binding]; other site 694427001870 FAD binding motif [chemical binding]; other site 694427001871 phosphate binding motif [ion binding]; other site 694427001872 beta-alpha-beta structure motif; other site 694427001873 NAD binding pocket [chemical binding]; other site 694427001874 Iron coordination center [ion binding]; other site 694427001875 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694427001876 non-specific DNA binding site [nucleotide binding]; other site 694427001877 salt bridge; other site 694427001878 sequence-specific DNA binding site [nucleotide binding]; other site 694427001879 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 694427001880 Putative zinc ribbon domain; Region: DUF164; pfam02591 694427001881 Uncharacterized conserved protein [Function unknown]; Region: COG0327 694427001882 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 694427001883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 694427001884 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 694427001885 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 694427001886 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 694427001887 catalytic residues [active] 694427001888 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 694427001889 Peptidase family M50; Region: Peptidase_M50; pfam02163 694427001890 active site 694427001891 putative substrate binding region [chemical binding]; other site 694427001892 Domain of unknown function (DU1801); Region: DUF1801; cl17490 694427001893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427001894 ABC transporter signature motif; other site 694427001895 Walker B; other site 694427001896 D-loop; other site 694427001897 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 694427001898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427001899 Walker A/P-loop; other site 694427001900 ATP binding site [chemical binding]; other site 694427001901 Q-loop/lid; other site 694427001902 ABC transporter signature motif; other site 694427001903 Walker B; other site 694427001904 D-loop; other site 694427001905 H-loop/switch region; other site 694427001906 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 694427001907 active site 694427001908 catalytic residues [active] 694427001909 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 694427001910 Beta-lactamase; Region: Beta-lactamase; cl17358 694427001911 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 694427001912 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 694427001913 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 694427001914 active site 694427001915 dimer interface [polypeptide binding]; other site 694427001916 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 694427001917 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 694427001918 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 694427001919 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427001920 catalytic triad [active] 694427001921 Methyltransferase domain; Region: Methyltransf_32; pfam13679 694427001922 Methyltransferase domain; Region: Methyltransf_31; pfam13847 694427001923 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 694427001924 dimer interface [polypeptide binding]; other site 694427001925 substrate binding site [chemical binding]; other site 694427001926 metal binding sites [ion binding]; metal-binding site 694427001927 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 694427001928 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 694427001929 FMN binding site [chemical binding]; other site 694427001930 active site 694427001931 catalytic residues [active] 694427001932 substrate binding site [chemical binding]; other site 694427001933 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 694427001934 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 694427001935 active site residue [active] 694427001936 AAA domain; Region: AAA_14; pfam13173 694427001937 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 694427001938 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 694427001939 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 694427001940 dimerization interface [polypeptide binding]; other site 694427001941 ATP binding site [chemical binding]; other site 694427001942 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 694427001943 dimerization interface [polypeptide binding]; other site 694427001944 ATP binding site [chemical binding]; other site 694427001945 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 694427001946 putative active site [active] 694427001947 catalytic triad [active] 694427001948 Predicted transcriptional regulators [Transcription]; Region: COG1733 694427001949 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 694427001950 dimerization interface [polypeptide binding]; other site 694427001951 putative DNA binding site [nucleotide binding]; other site 694427001952 putative Zn2+ binding site [ion binding]; other site 694427001953 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 694427001954 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 694427001955 NADP binding site [chemical binding]; other site 694427001956 Transcriptional regulator [Transcription]; Region: LysR; COG0583 694427001957 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 694427001958 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 694427001959 dimerization interface [polypeptide binding]; other site 694427001960 Helix-turn-helix domain; Region: HTH_18; pfam12833 694427001961 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 694427001962 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 694427001963 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 694427001964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 694427001965 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 694427001966 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 694427001967 N-terminal plug; other site 694427001968 ligand-binding site [chemical binding]; other site 694427001969 peptide chain release factor 1; Validated; Region: prfA; PRK00591 694427001970 This domain is found in peptide chain release factors; Region: PCRF; smart00937 694427001971 RF-1 domain; Region: RF-1; pfam00472 694427001972 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 694427001973 active site 694427001974 dimer interface [polypeptide binding]; other site 694427001975 Probable dihydrodipicolinate reductase; Region: PLN02775 694427001976 Cupin domain; Region: Cupin_2; pfam07883 694427001977 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 694427001978 active site 694427001979 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 694427001980 Uncharacterized conserved protein [Function unknown]; Region: COG3538 694427001981 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 694427001982 hybrid cluster protein; Provisional; Region: PRK05290 694427001983 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 694427001984 ACS interaction site; other site 694427001985 CODH interaction site; other site 694427001986 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 694427001987 hybrid metal cluster; other site 694427001988 4Fe-4S binding domain; Region: Fer4; cl02805 694427001989 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 694427001990 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 694427001991 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 694427001992 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 694427001993 ligand binding site [chemical binding]; other site 694427001994 flexible hinge region; other site 694427001995 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 694427001996 putative switch regulator; other site 694427001997 non-specific DNA interactions [nucleotide binding]; other site 694427001998 DNA binding site [nucleotide binding] 694427001999 sequence specific DNA binding site [nucleotide binding]; other site 694427002000 putative cAMP binding site [chemical binding]; other site 694427002001 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 694427002002 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427002003 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 694427002004 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 694427002005 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 694427002006 homodimer interface [polypeptide binding]; other site 694427002007 Walker A motif; other site 694427002008 ATP binding site [chemical binding]; other site 694427002009 hydroxycobalamin binding site [chemical binding]; other site 694427002010 Walker B motif; other site 694427002011 cobyric acid synthase; Provisional; Region: PRK00784 694427002012 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 694427002013 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 694427002014 catalytic triad [active] 694427002015 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 694427002016 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694427002017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427002018 homodimer interface [polypeptide binding]; other site 694427002019 catalytic residue [active] 694427002020 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 694427002021 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 694427002022 putative ligand binding site [chemical binding]; other site 694427002023 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 694427002024 AAA domain; Region: AAA_18; pfam13238 694427002025 homotrimer interface [polypeptide binding]; other site 694427002026 Walker A motif; other site 694427002027 GTP binding site [chemical binding]; other site 694427002028 Walker B motif; other site 694427002029 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 694427002030 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 694427002031 active site pocket [active] 694427002032 putative dimer interface [polypeptide binding]; other site 694427002033 putative cataytic base [active] 694427002034 cobalamin synthase; Reviewed; Region: cobS; PRK00235 694427002035 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 694427002036 catalytic core [active] 694427002037 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 694427002038 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 694427002039 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 694427002040 active site 694427002041 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 694427002042 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 694427002043 glutaminase active site [active] 694427002044 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 694427002045 dimer interface [polypeptide binding]; other site 694427002046 active site 694427002047 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 694427002048 dimer interface [polypeptide binding]; other site 694427002049 active site 694427002050 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 694427002051 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694427002052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427002053 homodimer interface [polypeptide binding]; other site 694427002054 catalytic residue [active] 694427002055 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 694427002056 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 694427002057 NADP binding site [chemical binding]; other site 694427002058 dimer interface [polypeptide binding]; other site 694427002059 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 694427002060 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 694427002061 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 694427002062 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427002063 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 694427002064 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 694427002065 Predicted thioesterase [General function prediction only]; Region: COG5496 694427002066 PRC-barrel domain; Region: PRC; pfam05239 694427002067 MgtE intracellular N domain; Region: MgtE_N; pfam03448 694427002068 FOG: CBS domain [General function prediction only]; Region: COG0517 694427002069 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 694427002070 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 694427002071 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 694427002072 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 694427002073 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 694427002074 oligomer interface [polypeptide binding]; other site 694427002075 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 694427002076 homopentamer interface [polypeptide binding]; other site 694427002077 active site 694427002078 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427002079 TPR motif; other site 694427002080 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427002081 binding surface 694427002082 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 694427002083 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 694427002084 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694427002085 ATP binding site [chemical binding]; other site 694427002086 putative Mg++ binding site [ion binding]; other site 694427002087 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427002088 nucleotide binding region [chemical binding]; other site 694427002089 ATP-binding site [chemical binding]; other site 694427002090 TRCF domain; Region: TRCF; pfam03461 694427002091 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 694427002092 nucleoside/Zn binding site; other site 694427002093 dimer interface [polypeptide binding]; other site 694427002094 catalytic motif [active] 694427002095 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 694427002096 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 694427002097 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427002098 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 694427002099 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 694427002100 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427002101 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427002102 binding surface 694427002103 Tetratricopeptide repeat; Region: TPR_16; pfam13432 694427002104 TPR motif; other site 694427002105 DNA gyrase subunit A; Validated; Region: PRK05560 694427002106 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 694427002107 CAP-like domain; other site 694427002108 active site 694427002109 primary dimer interface [polypeptide binding]; other site 694427002110 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 694427002111 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 694427002112 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 694427002113 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 694427002114 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 694427002115 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 694427002116 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609 694427002117 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 694427002118 replicative DNA helicase; Region: DnaB; TIGR00665 694427002119 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 694427002120 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 694427002121 Walker A motif; other site 694427002122 ATP binding site [chemical binding]; other site 694427002123 Walker B motif; other site 694427002124 DNA binding loops [nucleotide binding] 694427002125 nucleoside transporter; Region: 2A0110; TIGR00889 694427002126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427002127 putative substrate translocation pore; other site 694427002128 Bifunctional nuclease; Region: DNase-RNase; pfam02577 694427002129 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 694427002130 SmpB-tmRNA interface; other site 694427002131 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 694427002132 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 694427002133 acyl-activating enzyme (AAE) consensus motif; other site 694427002134 putative AMP binding site [chemical binding]; other site 694427002135 putative active site [active] 694427002136 putative CoA binding site [chemical binding]; other site 694427002137 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 694427002138 putative SAM binding site [chemical binding]; other site 694427002139 homodimer interface [polypeptide binding]; other site 694427002140 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 694427002141 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 694427002142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427002143 Walker A/P-loop; other site 694427002144 ATP binding site [chemical binding]; other site 694427002145 Q-loop/lid; other site 694427002146 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 694427002147 ABC transporter signature motif; other site 694427002148 Walker B; other site 694427002149 D-loop; other site 694427002150 ABC transporter; Region: ABC_tran_2; pfam12848 694427002151 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 694427002152 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 694427002153 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 694427002154 Mg++ binding site [ion binding]; other site 694427002155 putative catalytic motif [active] 694427002156 substrate binding site [chemical binding]; other site 694427002157 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 694427002158 oligomerization interface [polypeptide binding]; other site 694427002159 active site 694427002160 metal binding site [ion binding]; metal-binding site 694427002161 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 694427002162 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 694427002163 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 694427002164 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 694427002165 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 694427002166 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427002167 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427002168 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 694427002169 hypothetical protein; Provisional; Region: PRK12378 694427002170 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 694427002171 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 694427002172 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427002173 ligand binding site [chemical binding]; other site 694427002174 AAA domain; Region: AAA_30; pfam13604 694427002175 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 694427002176 Family description; Region: UvrD_C_2; pfam13538 694427002177 FkbH-like domain; Region: FkbH; TIGR01686 694427002178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694427002179 active site 694427002180 motif I; other site 694427002181 motif II; other site 694427002182 Predicted membrane protein [Function unknown]; Region: COG2364 694427002183 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 694427002184 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 694427002185 Peptidase family M49; Region: Peptidase_M49; pfam03571 694427002186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 694427002187 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 694427002188 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 694427002189 active site 694427002190 dimer interfaces [polypeptide binding]; other site 694427002191 catalytic residues [active] 694427002192 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 694427002193 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 694427002194 active site 694427002195 Zn binding site [ion binding]; other site 694427002196 pullulanase, type I; Region: pulA_typeI; TIGR02104 694427002197 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 694427002198 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 694427002199 Ca binding site [ion binding]; other site 694427002200 active site 694427002201 catalytic site [active] 694427002202 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 694427002203 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 694427002204 CoA-binding site [chemical binding]; other site 694427002205 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 694427002206 Clp amino terminal domain; Region: Clp_N; pfam02861 694427002207 Clp amino terminal domain; Region: Clp_N; pfam02861 694427002208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427002209 Walker A motif; other site 694427002210 ATP binding site [chemical binding]; other site 694427002211 Walker B motif; other site 694427002212 YtzH-like protein; Region: YtzH; pfam14165 694427002213 arginine finger; other site 694427002214 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427002215 Walker A motif; other site 694427002216 ATP binding site [chemical binding]; other site 694427002217 Walker B motif; other site 694427002218 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 694427002219 Major Facilitator Superfamily; Region: MFS_1; pfam07690 694427002220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427002221 putative substrate translocation pore; other site 694427002222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427002223 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 694427002224 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 694427002225 active site 694427002226 substrate binding site [chemical binding]; other site 694427002227 metal binding site [ion binding]; metal-binding site 694427002228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427002229 Walker A/P-loop; other site 694427002230 ATP binding site [chemical binding]; other site 694427002231 ABC transporter; Region: ABC_tran; pfam00005 694427002232 Q-loop/lid; other site 694427002233 ABC transporter signature motif; other site 694427002234 Walker B; other site 694427002235 D-loop; other site 694427002236 H-loop/switch region; other site 694427002237 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 694427002238 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 694427002239 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 694427002240 metal binding site [ion binding]; metal-binding site 694427002241 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 694427002242 dimer interface [polypeptide binding]; other site 694427002243 active site 694427002244 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 694427002245 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 694427002246 folate binding site [chemical binding]; other site 694427002247 NADP+ binding site [chemical binding]; other site 694427002248 thymidylate synthase; Reviewed; Region: thyA; PRK01827 694427002249 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 694427002250 dimerization interface [polypeptide binding]; other site 694427002251 active site 694427002252 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427002253 binding surface 694427002254 TPR motif; other site 694427002255 Tetratricopeptide repeat; Region: TPR_16; pfam13432 694427002256 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 694427002257 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 694427002258 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 694427002259 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427002260 ligand binding site [chemical binding]; other site 694427002261 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 694427002262 Uncharacterized conserved protein [Function unknown]; Region: COG4198 694427002263 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 694427002264 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745 694427002265 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 694427002266 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 694427002267 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 694427002268 Ferredoxin [Energy production and conversion]; Region: COG1146 694427002269 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 694427002270 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 694427002271 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427002272 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427002273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 694427002274 binding surface 694427002275 TPR motif; other site 694427002276 Domain of unknown function (DUF3244); Region: DUF3244; pfam11589 694427002277 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 694427002278 Preprotein binding site; other site 694427002279 SecA binding site; other site 694427002280 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 694427002281 MarR family; Region: MarR_2; cl17246 694427002282 MarR family; Region: MarR_2; cl17246 694427002283 Outer membrane efflux protein; Region: OEP; pfam02321 694427002284 Outer membrane efflux protein; Region: OEP; pfam02321 694427002285 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 694427002286 HlyD family secretion protein; Region: HlyD_3; pfam13437 694427002287 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 694427002288 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 694427002289 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 694427002290 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 694427002291 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 694427002292 Protein of unknown function (DUF805); Region: DUF805; pfam05656 694427002293 excinuclease ABC subunit B; Provisional; Region: PRK05298 694427002294 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694427002295 ATP binding site [chemical binding]; other site 694427002296 putative Mg++ binding site [ion binding]; other site 694427002297 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427002298 nucleotide binding region [chemical binding]; other site 694427002299 ATP-binding site [chemical binding]; other site 694427002300 Ultra-violet resistance protein B; Region: UvrB; pfam12344 694427002301 PspC domain; Region: PspC; pfam04024 694427002302 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 694427002303 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 694427002304 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 694427002305 Zn2+ binding site [ion binding]; other site 694427002306 Mg2+ binding site [ion binding]; other site 694427002307 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 694427002308 4-alpha-glucanotransferase; Region: PLN02950 694427002309 starch-binding site 2 [chemical binding]; other site 694427002310 starch-binding site 1 [chemical binding]; other site 694427002311 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 694427002312 starch-binding site 2 [chemical binding]; other site 694427002313 starch-binding site 1 [chemical binding]; other site 694427002314 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 694427002315 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 694427002316 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 694427002317 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 694427002318 active site 694427002319 amino acid transporter; Region: 2A0306; TIGR00909 694427002320 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 694427002321 amino acid transporter; Region: 2A0306; TIGR00909 694427002322 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 694427002323 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 694427002324 Catalytic domain of Protein Kinases; Region: PKc; cd00180 694427002325 active site 694427002326 ATP binding site [chemical binding]; other site 694427002327 substrate binding site [chemical binding]; other site 694427002328 activation loop (A-loop); other site 694427002329 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 694427002330 Putative esterase; Region: Esterase; pfam00756 694427002331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 694427002332 Predicted amidohydrolase [General function prediction only]; Region: COG0388 694427002333 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 694427002334 active site 694427002335 catalytic triad [active] 694427002336 dimer interface [polypeptide binding]; other site 694427002337 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 694427002338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427002339 NAD(P) binding site [chemical binding]; other site 694427002340 active site 694427002341 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 694427002342 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 694427002343 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427002344 Coenzyme A binding pocket [chemical binding]; other site 694427002345 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 694427002346 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 694427002347 trimer interface [polypeptide binding]; other site 694427002348 active site 694427002349 substrate binding site [chemical binding]; other site 694427002350 CoA binding site [chemical binding]; other site 694427002351 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 694427002352 active site 694427002353 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 694427002354 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 694427002355 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 694427002356 active site 694427002357 metal binding site [ion binding]; metal-binding site 694427002358 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 694427002359 E3 interaction surface; other site 694427002360 lipoyl attachment site [posttranslational modification]; other site 694427002361 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349 694427002362 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 694427002363 active site 694427002364 catalytic site [active] 694427002365 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 694427002366 dimer interface [polypeptide binding]; other site 694427002367 catalytic triad [active] 694427002368 peroxidatic and resolving cysteines [active] 694427002369 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 694427002370 active site 694427002371 catalytic site [active] 694427002372 substrate binding site [chemical binding]; other site 694427002373 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 694427002374 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 694427002375 FMN binding site [chemical binding]; other site 694427002376 substrate binding site [chemical binding]; other site 694427002377 putative catalytic residue [active] 694427002378 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 694427002379 putative ligand binding site [chemical binding]; other site 694427002380 Uncharacterized conserved protein [Function unknown]; Region: COG2353 694427002381 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 694427002382 active site 694427002383 catalytic residues [active] 694427002384 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 694427002385 DNA-binding site [nucleotide binding]; DNA binding site 694427002386 RNA-binding motif; other site 694427002387 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 694427002388 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 694427002389 ATP binding site [chemical binding]; other site 694427002390 putative Mg++ binding site [ion binding]; other site 694427002391 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427002392 nucleotide binding region [chemical binding]; other site 694427002393 ATP-binding site [chemical binding]; other site 694427002394 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 694427002395 RNA binding site [nucleotide binding]; other site 694427002396 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 694427002397 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 694427002398 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 694427002399 hinge; other site 694427002400 active site 694427002401 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 694427002402 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 694427002403 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 694427002404 Walker A/P-loop; other site 694427002405 ATP binding site [chemical binding]; other site 694427002406 Q-loop/lid; other site 694427002407 YfhG lipoprotein; Region: Lipoprotein_20; cl08141 694427002408 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 694427002409 ABC transporter signature motif; other site 694427002410 Walker B; other site 694427002411 D-loop; other site 694427002412 H-loop/switch region; other site 694427002413 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 694427002414 Flavoprotein; Region: Flavoprotein; pfam02441 694427002415 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 694427002416 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 694427002417 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 694427002418 ApbE family; Region: ApbE; pfam02424 694427002419 dihydroorotase; Reviewed; Region: PRK09236 694427002420 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 694427002421 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 694427002422 active site 694427002423 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 694427002424 Ligand binding site; other site 694427002425 Putative Catalytic site; other site 694427002426 DXD motif; other site 694427002427 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 694427002428 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 694427002429 Tetratricopeptide repeat; Region: TPR_16; pfam13432 694427002430 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427002431 TPR motif; other site 694427002432 binding surface 694427002433 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 694427002434 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 694427002435 TolA protein; Region: tolA_full; TIGR02794 694427002436 ATP synthase archaeal, H subunit; Region: AhaH; TIGR02926 694427002437 B12 binding domain; Region: B12-binding; pfam02310 694427002438 B12 binding site [chemical binding]; other site 694427002439 Radical SAM superfamily; Region: Radical_SAM; pfam04055 694427002440 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 694427002441 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 694427002442 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 694427002443 Ligand Binding Site [chemical binding]; other site 694427002444 TIGR00269 family protein; Region: TIGR00269 694427002445 Protein of unknown function, DUF486; Region: DUF486; cl01236 694427002446 M6 family metalloprotease domain; Region: M6dom_TIGR03296 694427002447 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 694427002448 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 694427002449 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 694427002450 ABC transporter; Region: ABC_tran_2; pfam12848 694427002451 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 694427002452 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 694427002453 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 694427002454 NAD(P) binding site [chemical binding]; other site 694427002455 homodimer interface [polypeptide binding]; other site 694427002456 substrate binding site [chemical binding]; other site 694427002457 active site 694427002458 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 694427002459 Galactose oxidase, central domain; Region: Kelch_3; cl02701 694427002460 mutatrotase, YjhT family; Region: muta_rot_YjhT; TIGR03547 694427002461 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 694427002462 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 694427002463 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 694427002464 inhibitor-cofactor binding pocket; inhibition site 694427002465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427002466 catalytic residue [active] 694427002467 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 694427002468 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 694427002469 active site 694427002470 metal binding site [ion binding]; metal-binding site 694427002471 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 694427002472 extended (e) SDRs; Region: SDR_e; cd08946 694427002473 NAD(P) binding site [chemical binding]; other site 694427002474 active site 694427002475 substrate binding site [chemical binding]; other site 694427002476 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 694427002477 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 694427002478 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 694427002479 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 694427002480 WbqC-like protein family; Region: WbqC; pfam08889 694427002481 Bacterial sugar transferase; Region: Bac_transf; pfam02397 694427002482 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427002483 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 694427002484 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 694427002485 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 694427002486 active site 694427002487 homodimer interface [polypeptide binding]; other site 694427002488 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 694427002489 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 694427002490 putative NAD(P) binding site [chemical binding]; other site 694427002491 active site 694427002492 putative substrate binding site [chemical binding]; other site 694427002493 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 694427002494 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 694427002495 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 694427002496 NAD(P) binding site [chemical binding]; other site 694427002497 homodimer interface [polypeptide binding]; other site 694427002498 substrate binding site [chemical binding]; other site 694427002499 active site 694427002500 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 694427002501 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 694427002502 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427002503 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 694427002504 putative ligand binding site [chemical binding]; other site 694427002505 putative catalytic site [active] 694427002506 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694427002507 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 694427002508 active site 694427002509 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 694427002510 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 694427002511 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 694427002512 active site 694427002513 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 694427002514 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 694427002515 NAD binding site [chemical binding]; other site 694427002516 homotetramer interface [polypeptide binding]; other site 694427002517 homodimer interface [polypeptide binding]; other site 694427002518 active site 694427002519 substrate binding site [chemical binding]; other site 694427002520 extended (e) SDRs; Region: SDR_e; cd08946 694427002521 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 694427002522 NAD(P) binding site [chemical binding]; other site 694427002523 active site 694427002524 substrate binding site [chemical binding]; other site 694427002525 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 694427002526 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 694427002527 NAD binding site [chemical binding]; other site 694427002528 homotetramer interface [polypeptide binding]; other site 694427002529 homodimer interface [polypeptide binding]; other site 694427002530 substrate binding site [chemical binding]; other site 694427002531 active site 694427002532 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 694427002533 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 694427002534 substrate binding site; other site 694427002535 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 694427002536 FAD binding pocket [chemical binding]; other site 694427002537 conserved FAD binding motif [chemical binding]; other site 694427002538 phosphate binding motif [ion binding]; other site 694427002539 beta-alpha-beta structure motif; other site 694427002540 NAD binding pocket [chemical binding]; other site 694427002541 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 694427002542 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 694427002543 inhibitor-cofactor binding pocket; inhibition site 694427002544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427002545 catalytic residue [active] 694427002546 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 694427002547 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 694427002548 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 694427002549 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 694427002550 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 694427002551 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 694427002552 SLBB domain; Region: SLBB; pfam10531 694427002553 SLBB domain; Region: SLBB; pfam10531 694427002554 SLBB domain; Region: SLBB; pfam10531 694427002555 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 694427002556 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 694427002557 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 694427002558 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 694427002559 heterodimer interface [polypeptide binding]; other site 694427002560 homodimer interface [polypeptide binding]; other site 694427002561 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 694427002562 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 694427002563 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 694427002564 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 694427002565 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 694427002566 nudix motif; other site 694427002567 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 694427002568 carboxyltransferase (CT) interaction site; other site 694427002569 biotinylation site [posttranslational modification]; other site 694427002570 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 694427002571 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 694427002572 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 694427002573 Protein of unknown function (DUF721); Region: DUF721; pfam05258 694427002574 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 694427002575 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 694427002576 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 694427002577 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 694427002578 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 694427002579 active site 694427002580 catalytic motif [active] 694427002581 Zn binding site [ion binding]; other site 694427002582 Predicted permeases [General function prediction only]; Region: COG0795 694427002583 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 694427002584 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 694427002585 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 694427002586 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 694427002587 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 694427002588 dimerization interface [polypeptide binding]; other site 694427002589 active site 694427002590 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 694427002591 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 694427002592 putative NAD(P) binding site [chemical binding]; other site 694427002593 homodimer interface [polypeptide binding]; other site 694427002594 homotetramer interface [polypeptide binding]; other site 694427002595 active site 694427002596 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 694427002597 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 694427002598 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 694427002599 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 694427002600 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 694427002601 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 694427002602 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427002603 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 694427002604 chaperone protein DnaJ; Provisional; Region: PRK14289 694427002605 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 694427002606 HSP70 interaction site [polypeptide binding]; other site 694427002607 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 694427002608 substrate binding site [polypeptide binding]; other site 694427002609 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 694427002610 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 694427002611 dimer interface [polypeptide binding]; other site 694427002612 GrpE; Region: GrpE; pfam01025 694427002613 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 694427002614 dimer interface [polypeptide binding]; other site 694427002615 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 694427002616 cell surface protein SprA; Region: surface_SprA; TIGR04189 694427002617 Motility related/secretion protein; Region: SprA_N; pfam14349 694427002618 Motility related/secretion protein; Region: SprA_N; pfam14349 694427002619 Motility related/secretion protein; Region: SprA_N; pfam14349 694427002620 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 694427002621 RuvA N terminal domain; Region: RuvA_N; pfam01330 694427002622 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 694427002623 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 694427002624 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 694427002625 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 694427002626 Proline dehydrogenase; Region: Pro_dh; cl03282 694427002627 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 694427002628 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 694427002629 Glutamate binding site [chemical binding]; other site 694427002630 NAD binding site [chemical binding]; other site 694427002631 catalytic residues [active] 694427002632 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 694427002633 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 694427002634 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 694427002635 active site clefts [active] 694427002636 zinc binding site [ion binding]; other site 694427002637 dimer interface [polypeptide binding]; other site 694427002638 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 694427002639 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 694427002640 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 694427002641 MutS domain III; Region: MutS_III; pfam05192 694427002642 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427002643 Walker A/P-loop; other site 694427002644 ATP binding site [chemical binding]; other site 694427002645 Q-loop/lid; other site 694427002646 ABC transporter signature motif; other site 694427002647 Walker B; other site 694427002648 D-loop; other site 694427002649 H-loop/switch region; other site 694427002650 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 694427002651 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427002652 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427002653 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427002654 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427002655 catalytic residues [active] 694427002656 YtkA-like; Region: YtkA; pfam13115 694427002657 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427002658 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 694427002659 Heavy-metal-associated domain; Region: HMA; pfam00403 694427002660 metal-binding site [ion binding] 694427002661 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 694427002662 Outer membrane efflux protein; Region: OEP; pfam02321 694427002663 Outer membrane efflux protein; Region: OEP; pfam02321 694427002664 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427002665 HlyD family secretion protein; Region: HlyD_3; pfam13437 694427002666 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 694427002667 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427002668 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 694427002669 DNA binding residues [nucleotide binding] 694427002670 H+ Antiporter protein; Region: 2A0121; TIGR00900 694427002671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427002672 putative substrate translocation pore; other site 694427002673 MarR family; Region: MarR_2; cl17246 694427002674 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 694427002675 Sulfatase; Region: Sulfatase; pfam00884 694427002676 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 694427002677 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 694427002678 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 694427002679 heterodimer interface [polypeptide binding]; other site 694427002680 substrate interaction site [chemical binding]; other site 694427002681 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 694427002682 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 694427002683 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 694427002684 active site 694427002685 substrate binding site [chemical binding]; other site 694427002686 coenzyme B12 binding site [chemical binding]; other site 694427002687 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 694427002688 B12 binding site [chemical binding]; other site 694427002689 cobalt ligand [ion binding]; other site 694427002690 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427002691 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427002692 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 694427002693 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 694427002694 Methyltransferase domain; Region: Methyltransf_27; pfam13708 694427002695 MG2 domain; Region: A2M_N; pfam01835 694427002696 Cation efflux family; Region: Cation_efflux; cl00316 694427002697 PAS domain S-box; Region: sensory_box; TIGR00229 694427002698 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427002699 putative active site [active] 694427002700 heme pocket [chemical binding]; other site 694427002701 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427002702 PAS fold; Region: PAS_3; pfam08447 694427002703 putative active site [active] 694427002704 heme pocket [chemical binding]; other site 694427002705 PAS domain S-box; Region: sensory_box; TIGR00229 694427002706 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427002707 putative active site [active] 694427002708 heme pocket [chemical binding]; other site 694427002709 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 694427002710 Histidine kinase; Region: HisKA_3; pfam07730 694427002711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427002712 ATP binding site [chemical binding]; other site 694427002713 Mg2+ binding site [ion binding]; other site 694427002714 G-X-G motif; other site 694427002715 Pirin-related protein [General function prediction only]; Region: COG1741 694427002716 Pirin; Region: Pirin; pfam02678 694427002717 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 694427002718 Predicted membrane protein [Function unknown]; Region: COG2311 694427002719 Protein of unknown function (DUF418); Region: DUF418; pfam04235 694427002720 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 694427002721 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 694427002722 substrate binding site [chemical binding]; other site 694427002723 ligand binding site [chemical binding]; other site 694427002724 Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...; Region: AcnA_Mitochon_Swivel; cd01578 694427002725 substrate binding site [chemical binding]; other site 694427002726 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 694427002727 dimer interface [polypeptide binding]; other site 694427002728 Citrate synthase; Region: Citrate_synt; pfam00285 694427002729 active site 694427002730 citrylCoA binding site [chemical binding]; other site 694427002731 oxalacetate/citrate binding site [chemical binding]; other site 694427002732 coenzyme A binding site [chemical binding]; other site 694427002733 catalytic triad [active] 694427002734 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 694427002735 four helix bundle protein; Region: TIGR02436 694427002736 isocitrate dehydrogenase; Validated; Region: PRK08299 694427002737 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 694427002738 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 694427002739 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427002740 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 694427002741 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427002742 DNA binding residues [nucleotide binding] 694427002743 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 694427002744 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 694427002745 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 694427002746 protein binding site [polypeptide binding]; other site 694427002747 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 694427002748 protein binding site [polypeptide binding]; other site 694427002749 enolase; Provisional; Region: eno; PRK00077 694427002750 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 694427002751 dimer interface [polypeptide binding]; other site 694427002752 metal binding site [ion binding]; metal-binding site 694427002753 substrate binding pocket [chemical binding]; other site 694427002754 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 694427002755 MutS domain III; Region: MutS_III; pfam05192 694427002756 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 694427002757 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427002758 Walker A/P-loop; other site 694427002759 ATP binding site [chemical binding]; other site 694427002760 Q-loop/lid; other site 694427002761 ABC transporter signature motif; other site 694427002762 Walker B; other site 694427002763 D-loop; other site 694427002764 H-loop/switch region; other site 694427002765 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 694427002766 Smr domain; Region: Smr; pfam01713 694427002767 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 694427002768 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 694427002769 homodimer interface [polypeptide binding]; other site 694427002770 metal binding site [ion binding]; metal-binding site 694427002771 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 694427002772 homodimer interface [polypeptide binding]; other site 694427002773 active site 694427002774 putative chemical substrate binding site [chemical binding]; other site 694427002775 metal binding site [ion binding]; metal-binding site 694427002776 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 694427002777 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 694427002778 Walker A/P-loop; other site 694427002779 ATP binding site [chemical binding]; other site 694427002780 Q-loop/lid; other site 694427002781 ABC transporter signature motif; other site 694427002782 Walker B; other site 694427002783 D-loop; other site 694427002784 H-loop/switch region; other site 694427002785 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 694427002786 DNA-binding site [nucleotide binding]; DNA binding site 694427002787 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 694427002788 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 694427002789 catalytic triad [active] 694427002790 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 694427002791 Beta-lactamase; Region: Beta-lactamase; pfam00144 694427002792 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 694427002793 dihydrodipicolinate synthase; Region: dapA; TIGR00674 694427002794 dimer interface [polypeptide binding]; other site 694427002795 active site 694427002796 catalytic residue [active] 694427002797 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 694427002798 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 694427002799 nucleotide binding pocket [chemical binding]; other site 694427002800 K-X-D-G motif; other site 694427002801 catalytic site [active] 694427002802 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 694427002803 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 694427002804 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 694427002805 Dimer interface [polypeptide binding]; other site 694427002806 BRCT sequence motif; other site 694427002807 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 694427002808 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694427002809 FtsX-like permease family; Region: FtsX; pfam02687 694427002810 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 694427002811 four helix bundle protein; Region: TIGR02436 694427002812 aspartate aminotransferase; Provisional; Region: PRK07568 694427002813 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694427002814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427002815 homodimer interface [polypeptide binding]; other site 694427002816 catalytic residue [active] 694427002817 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427002818 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 694427002819 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427002820 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 694427002821 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 694427002822 Walker A/P-loop; other site 694427002823 ATP binding site [chemical binding]; other site 694427002824 Q-loop/lid; other site 694427002825 ABC transporter signature motif; other site 694427002826 Walker B; other site 694427002827 D-loop; other site 694427002828 H-loop/switch region; other site 694427002829 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 694427002830 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 694427002831 ABC-ATPase subunit interface; other site 694427002832 dimer interface [polypeptide binding]; other site 694427002833 putative PBP binding regions; other site 694427002834 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 694427002835 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 694427002836 putative ligand binding site [chemical binding]; other site 694427002837 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 694427002838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427002839 Major Facilitator Superfamily; Region: MFS_1; pfam07690 694427002840 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 694427002841 G1 box; other site 694427002842 GTP/Mg2+ binding site [chemical binding]; other site 694427002843 Switch I region; other site 694427002844 G2 box; other site 694427002845 G3 box; other site 694427002846 Switch II region; other site 694427002847 G4 box; other site 694427002848 G5 box; other site 694427002849 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 694427002850 Na binding site [ion binding]; other site 694427002851 recombination protein RecR; Reviewed; Region: recR; PRK00076 694427002852 RecR protein; Region: RecR; pfam02132 694427002853 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 694427002854 putative active site [active] 694427002855 putative metal-binding site [ion binding]; other site 694427002856 tetramer interface [polypeptide binding]; other site 694427002857 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 694427002858 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 694427002859 Coenzyme A binding pocket [chemical binding]; other site 694427002860 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 694427002861 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 694427002862 ligand binding site [chemical binding]; other site 694427002863 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 694427002864 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 694427002865 NAD binding site [chemical binding]; other site 694427002866 homodimer interface [polypeptide binding]; other site 694427002867 active site 694427002868 substrate binding site [chemical binding]; other site 694427002869 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427002870 active site 694427002871 Tetratricopeptide repeat; Region: TPR_16; pfam13432 694427002872 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 694427002873 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427002874 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 694427002875 ligand binding site [chemical binding]; other site 694427002876 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 694427002877 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 694427002878 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 694427002879 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 694427002880 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 694427002881 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427002882 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 694427002883 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 694427002884 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427002885 ligand binding site [chemical binding]; other site 694427002886 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 694427002887 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 694427002888 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 694427002889 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 694427002890 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694427002891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427002892 homodimer interface [polypeptide binding]; other site 694427002893 catalytic residue [active] 694427002894 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 694427002895 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 694427002896 Nitrogen regulatory protein P-II; Region: P-II; smart00938 694427002897 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 694427002898 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 694427002899 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 694427002900 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 694427002901 Nitrogen regulatory protein P-II; Region: P-II; smart00938 694427002902 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 694427002903 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 694427002904 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 694427002905 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 694427002906 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 694427002907 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 694427002908 active site 694427002909 dimer interface [polypeptide binding]; other site 694427002910 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 694427002911 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 694427002912 active site 694427002913 FMN binding site [chemical binding]; other site 694427002914 substrate binding site [chemical binding]; other site 694427002915 3Fe-4S cluster binding site [ion binding]; other site 694427002916 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 694427002917 domain interface; other site 694427002918 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 694427002919 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 694427002920 asparagine synthetase B; Provisional; Region: asnB; PRK09431 694427002921 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 694427002922 active site 694427002923 dimer interface [polypeptide binding]; other site 694427002924 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 694427002925 Ligand Binding Site [chemical binding]; other site 694427002926 Molecular Tunnel; other site 694427002927 AAA domain; Region: AAA_28; pfam13521 694427002928 AAA domain; Region: AAA_17; pfam13207 694427002929 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 694427002930 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427002931 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 694427002932 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 694427002933 Catalytic site [active] 694427002934 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 694427002935 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 694427002936 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427002937 Walker A/P-loop; other site 694427002938 ATP binding site [chemical binding]; other site 694427002939 Q-loop/lid; other site 694427002940 ABC transporter signature motif; other site 694427002941 Walker B; other site 694427002942 D-loop; other site 694427002943 H-loop/switch region; other site 694427002944 Bacterial sugar transferase; Region: Bac_transf; cl00939 694427002945 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 694427002946 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 694427002947 active site 694427002948 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 694427002949 homodimer interface [polypeptide binding]; other site 694427002950 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1817 694427002951 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1817 694427002952 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 694427002953 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 694427002954 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427002955 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 694427002956 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427002957 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 694427002958 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694427002959 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 694427002960 active site 694427002961 LytTr DNA-binding domain; Region: LytTR; smart00850 694427002962 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 694427002963 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 694427002964 Acyltransferase family; Region: Acyl_transf_3; pfam01757 694427002965 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 694427002966 active site 694427002967 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 694427002968 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 694427002969 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 694427002970 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 694427002971 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 694427002972 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694427002973 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427002974 active site 694427002975 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694427002976 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 694427002977 active site 694427002978 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 694427002979 putative ligand binding site [chemical binding]; other site 694427002980 putative catalytic site [active] 694427002981 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694427002982 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 694427002983 metal-binding site 694427002984 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694427002985 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 694427002986 active site 694427002987 Methyltransferase domain; Region: Methyltransf_31; pfam13847 694427002988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427002989 S-adenosylmethionine binding site [chemical binding]; other site 694427002990 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 694427002991 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 694427002992 Walker A/P-loop; other site 694427002993 ATP binding site [chemical binding]; other site 694427002994 Q-loop/lid; other site 694427002995 ABC transporter signature motif; other site 694427002996 Walker B; other site 694427002997 D-loop; other site 694427002998 H-loop/switch region; other site 694427002999 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 694427003000 putative carbohydrate binding site [chemical binding]; other site 694427003001 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 694427003002 four helix bundle protein; Region: TIGR02436 694427003003 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 694427003004 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 694427003005 inhibitor-cofactor binding pocket; inhibition site 694427003006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427003007 catalytic residue [active] 694427003008 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 694427003009 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 694427003010 dimer interface [polypeptide binding]; other site 694427003011 active site 694427003012 CoA binding pocket [chemical binding]; other site 694427003013 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 694427003014 classical (c) SDRs; Region: SDR_c; cd05233 694427003015 NAD(P) binding site [chemical binding]; other site 694427003016 active site 694427003017 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 694427003018 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 694427003019 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 694427003020 putative trimer interface [polypeptide binding]; other site 694427003021 putative CoA binding site [chemical binding]; other site 694427003022 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 694427003023 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 694427003024 Ligand binding site; other site 694427003025 Putative Catalytic site; other site 694427003026 DXD motif; other site 694427003027 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 694427003028 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 694427003029 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 694427003030 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 694427003031 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 694427003032 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 694427003033 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 694427003034 substrate binding site [chemical binding]; other site 694427003035 glutamase interaction surface [polypeptide binding]; other site 694427003036 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 694427003037 active site 694427003038 Tetratricopeptide repeat; Region: TPR_16; pfam13432 694427003039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427003040 TPR motif; other site 694427003041 binding surface 694427003042 Bacterial SH3 domain homologues; Region: SH3b; smart00287 694427003043 Oxygen tolerance; Region: BatD; pfam13584 694427003044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427003045 TPR motif; other site 694427003046 binding surface 694427003047 TPR repeat; Region: TPR_11; pfam13414 694427003048 Aerotolerance regulator N-terminal; Region: BatA; cl06567 694427003049 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 694427003050 metal ion-dependent adhesion site (MIDAS); other site 694427003051 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 694427003052 metal ion-dependent adhesion site (MIDAS); other site 694427003053 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 694427003054 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 694427003055 metal ion-dependent adhesion site (MIDAS); other site 694427003056 MoxR-like ATPases [General function prediction only]; Region: COG0714 694427003057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427003058 Walker A motif; other site 694427003059 ATP binding site [chemical binding]; other site 694427003060 Walker B motif; other site 694427003061 arginine finger; other site 694427003062 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 694427003063 IHF - DNA interface [nucleotide binding]; other site 694427003064 IHF dimer interface [polypeptide binding]; other site 694427003065 Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216 694427003066 IHF dimer interface [polypeptide binding]; other site 694427003067 IHF - DNA interface [nucleotide binding]; other site 694427003068 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 694427003069 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 694427003070 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427003071 FeS/SAM binding site; other site 694427003072 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 694427003073 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 694427003074 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 694427003075 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 694427003076 ribosomal protein L33; Region: rpl33; CHL00104 694427003077 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 694427003078 competence damage-inducible protein A; Provisional; Region: PRK00549 694427003079 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 694427003080 putative MPT binding site; other site 694427003081 Competence-damaged protein; Region: CinA; pfam02464 694427003082 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 694427003083 Predicted membrane protein [Function unknown]; Region: COG2860 694427003084 UPF0126 domain; Region: UPF0126; pfam03458 694427003085 UPF0126 domain; Region: UPF0126; pfam03458 694427003086 Preprotein translocase SecG subunit; Region: SecG; pfam03840 694427003087 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 694427003088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427003089 Walker A motif; other site 694427003090 ATP binding site [chemical binding]; other site 694427003091 Walker B motif; other site 694427003092 arginine finger; other site 694427003093 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 694427003094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 694427003095 binding surface 694427003096 TPR motif; other site 694427003097 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427003098 binding surface 694427003099 TPR motif; other site 694427003100 PBP superfamily domain; Region: PBP_like_2; pfam12849 694427003101 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 694427003102 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 694427003103 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 694427003104 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 694427003105 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 694427003106 putative active site [active] 694427003107 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427003108 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 694427003109 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694427003110 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 694427003111 active site 694427003112 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 694427003113 oligomerisation interface [polypeptide binding]; other site 694427003114 mobile loop; other site 694427003115 roof hairpin; other site 694427003116 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 694427003117 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 694427003118 ring oligomerisation interface [polypeptide binding]; other site 694427003119 ATP/Mg binding site [chemical binding]; other site 694427003120 stacking interactions; other site 694427003121 hinge regions; other site 694427003122 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 694427003123 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 694427003124 active site 694427003125 Fn3 associated; Region: Fn3_assoc; pfam13287 694427003126 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 694427003127 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 694427003128 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 694427003129 ATP-binding site [chemical binding]; other site 694427003130 Sugar specificity; other site 694427003131 Pyrimidine base specificity; other site 694427003132 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 694427003133 active site 694427003134 catalytic site [active] 694427003135 substrate binding site [chemical binding]; other site 694427003136 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 694427003137 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 694427003138 substrate binding pocket [chemical binding]; other site 694427003139 membrane-bound complex binding site; other site 694427003140 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 694427003141 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 694427003142 N-acetyl-D-glucosamine binding site [chemical binding]; other site 694427003143 catalytic residue [active] 694427003144 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 694427003145 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 694427003146 phosphoserine phosphatase SerB; Region: serB; TIGR00338 694427003147 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694427003148 motif II; other site 694427003149 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 694427003150 NADH(P)-binding; Region: NAD_binding_10; pfam13460 694427003151 NAD binding site [chemical binding]; other site 694427003152 active site 694427003153 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 694427003154 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 694427003155 hexamer interface [polypeptide binding]; other site 694427003156 ligand binding site [chemical binding]; other site 694427003157 putative active site [active] 694427003158 NAD(P) binding site [chemical binding]; other site 694427003159 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 694427003160 pantothenate kinase; Reviewed; Region: PRK13320 694427003161 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 694427003162 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 694427003163 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 694427003164 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 694427003165 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 694427003166 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 694427003167 acyl-activating enzyme (AAE) consensus motif; other site 694427003168 AMP binding site [chemical binding]; other site 694427003169 active site 694427003170 CoA binding site [chemical binding]; other site 694427003171 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 694427003172 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 694427003173 putative tRNA-binding site [nucleotide binding]; other site 694427003174 B3/4 domain; Region: B3_4; pfam03483 694427003175 tRNA synthetase B5 domain; Region: B5; pfam03484 694427003176 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 694427003177 dimer interface [polypeptide binding]; other site 694427003178 motif 1; other site 694427003179 motif 3; other site 694427003180 motif 2; other site 694427003181 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 694427003182 four helix bundle protein; Region: TIGR02436 694427003183 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 694427003184 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 694427003185 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 694427003186 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694427003187 catalytic residue [active] 694427003188 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 694427003189 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 694427003190 NADP binding site [chemical binding]; other site 694427003191 active site 694427003192 putative substrate binding site [chemical binding]; other site 694427003193 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 694427003194 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 694427003195 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 694427003196 substrate binding site; other site 694427003197 tetramer interface; other site 694427003198 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 694427003199 RNA binding surface [nucleotide binding]; other site 694427003200 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 694427003201 putative active site [active] 694427003202 catalytic residue [active] 694427003203 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 694427003204 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 694427003205 5S rRNA interface [nucleotide binding]; other site 694427003206 CTC domain interface [polypeptide binding]; other site 694427003207 L16 interface [polypeptide binding]; other site 694427003208 aspartate aminotransferase; Provisional; Region: PRK05764 694427003209 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694427003210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427003211 homodimer interface [polypeptide binding]; other site 694427003212 catalytic residue [active] 694427003213 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 694427003214 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 694427003215 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 694427003216 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 694427003217 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 694427003218 23S rRNA binding site [nucleotide binding]; other site 694427003219 L21 binding site [polypeptide binding]; other site 694427003220 L13 binding site [polypeptide binding]; other site 694427003221 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 694427003222 RNA methyltransferase, RsmE family; Region: TIGR00046 694427003223 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 694427003224 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 694427003225 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 694427003226 homodimer interface [polypeptide binding]; other site 694427003227 NADP binding site [chemical binding]; other site 694427003228 substrate binding site [chemical binding]; other site 694427003229 signal recognition particle protein; Provisional; Region: PRK10867 694427003230 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 694427003231 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 694427003232 P loop; other site 694427003233 GTP binding site [chemical binding]; other site 694427003234 Signal peptide binding domain; Region: SRP_SPB; pfam02978 694427003235 Protein of unknown function, DUF479; Region: DUF479; cl01203 694427003236 Domain of unknown function DUF11; Region: DUF11; cl17728 694427003237 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 694427003238 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 694427003239 Catalytic dyad [active] 694427003240 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 694427003241 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 694427003242 active site 694427003243 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 694427003244 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 694427003245 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 694427003246 dimer interface [polypeptide binding]; other site 694427003247 FMN binding site [chemical binding]; other site 694427003248 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 694427003249 dimer interface [polypeptide binding]; other site 694427003250 FMN binding site [chemical binding]; other site 694427003251 S-adenosylmethionine synthetase; Validated; Region: PRK05250 694427003252 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 694427003253 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 694427003254 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 694427003255 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 694427003256 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 694427003257 Transglycosylase; Region: Transgly; pfam00912 694427003258 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 694427003259 PEGA domain; Region: PEGA; pfam08308 694427003260 Ion channel; Region: Ion_trans_2; pfam07885 694427003261 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 694427003262 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 694427003263 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 694427003264 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 694427003265 RNA binding site [nucleotide binding]; other site 694427003266 active site 694427003267 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 694427003268 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 694427003269 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 694427003270 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 694427003271 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 694427003272 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 694427003273 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694427003274 catalytic residue [active] 694427003275 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 694427003276 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 694427003277 active site 694427003278 putative DNA-binding cleft [nucleotide binding]; other site 694427003279 dimer interface [polypeptide binding]; other site 694427003280 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 694427003281 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 694427003282 Transposase IS200 like; Region: Y1_Tnp; pfam01797 694427003283 DNA repair protein RadA; Provisional; Region: PRK11823 694427003284 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 694427003285 Walker A motif/ATP binding site; other site 694427003286 ATP binding site [chemical binding]; other site 694427003287 Walker B motif; other site 694427003288 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 694427003289 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 694427003290 AAA domain; Region: AAA_14; pfam13173 694427003291 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 694427003292 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 694427003293 MG2 domain; Region: A2M_N; pfam01835 694427003294 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 694427003295 Alpha-2-macroglobulin family; Region: A2M; pfam00207 694427003296 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 694427003297 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 694427003298 putative ATP binding site [chemical binding]; other site 694427003299 putative substrate interface [chemical binding]; other site 694427003300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427003301 binding surface 694427003302 Tetratricopeptide repeat; Region: TPR_16; pfam13432 694427003303 TPR motif; other site 694427003304 TPR repeat; Region: TPR_11; pfam13414 694427003305 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 694427003306 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 694427003307 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 694427003308 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 694427003309 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 694427003310 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 694427003311 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 694427003312 DoxX; Region: DoxX; pfam07681 694427003313 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 694427003314 triosephosphate isomerase; Provisional; Region: PRK14567 694427003315 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 694427003316 substrate binding site [chemical binding]; other site 694427003317 dimer interface [polypeptide binding]; other site 694427003318 catalytic triad [active] 694427003319 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 694427003320 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 694427003321 Tannase and feruloyl esterase; Region: Tannase; pfam07519 694427003322 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 694427003323 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 694427003324 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 694427003325 ligand binding site [chemical binding]; other site 694427003326 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 694427003327 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 694427003328 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 694427003329 putative active site [active] 694427003330 putative metal binding site [ion binding]; other site 694427003331 Domain of unknown function DUF59; Region: DUF59; cl00941 694427003332 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 694427003333 active site 694427003334 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 694427003335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427003336 S-adenosylmethionine binding site [chemical binding]; other site 694427003337 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 694427003338 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 694427003339 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 694427003340 DNA topoisomerase III; Provisional; Region: PRK07726 694427003341 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 694427003342 active site 694427003343 putative interdomain interaction site [polypeptide binding]; other site 694427003344 putative metal-binding site [ion binding]; other site 694427003345 putative nucleotide binding site [chemical binding]; other site 694427003346 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 694427003347 domain I; other site 694427003348 DNA binding groove [nucleotide binding] 694427003349 phosphate binding site [ion binding]; other site 694427003350 domain II; other site 694427003351 domain III; other site 694427003352 nucleotide binding site [chemical binding]; other site 694427003353 catalytic site [active] 694427003354 domain IV; other site 694427003355 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 694427003356 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 694427003357 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 694427003358 NAD synthetase; Reviewed; Region: nadE; PRK02628 694427003359 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 694427003360 multimer interface [polypeptide binding]; other site 694427003361 active site 694427003362 catalytic triad [active] 694427003363 protein interface 1 [polypeptide binding]; other site 694427003364 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 694427003365 homodimer interface [polypeptide binding]; other site 694427003366 NAD binding pocket [chemical binding]; other site 694427003367 ATP binding pocket [chemical binding]; other site 694427003368 Mg binding site [ion binding]; other site 694427003369 active-site loop [active] 694427003370 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 694427003371 Mechanosensitive ion channel; Region: MS_channel; pfam00924 694427003372 seryl-tRNA synthetase; Provisional; Region: PRK05431 694427003373 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 694427003374 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 694427003375 dimer interface [polypeptide binding]; other site 694427003376 active site 694427003377 motif 1; other site 694427003378 motif 2; other site 694427003379 motif 3; other site 694427003380 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 694427003381 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 694427003382 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 694427003383 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 694427003384 putative active site [active] 694427003385 metal binding site [ion binding]; metal-binding site 694427003386 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 694427003387 4-alpha-glucanotransferase; Region: PLN02950 694427003388 starch-binding site 2 [chemical binding]; other site 694427003389 starch-binding site 1 [chemical binding]; other site 694427003390 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 694427003391 starch-binding site 2 [chemical binding]; other site 694427003392 starch-binding site 1 [chemical binding]; other site 694427003393 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 694427003394 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 694427003395 dimerization interface [polypeptide binding]; other site 694427003396 ATP binding site [chemical binding]; other site 694427003397 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 694427003398 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 694427003399 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 694427003400 Probable Catalytic site; other site 694427003401 metal-binding site 694427003402 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 694427003403 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427003404 putative ADP-binding pocket [chemical binding]; other site 694427003405 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 694427003406 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 694427003407 Ligand binding site; other site 694427003408 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427003409 active site 694427003410 Protein of unknown function DUF70; Region: DUF70; cl00785 694427003411 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 694427003412 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 694427003413 Domain of unknown function DUF77; Region: DUF77; pfam01910 694427003414 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 694427003415 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 694427003416 Sporulation related domain; Region: SPOR; pfam05036 694427003417 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 694427003418 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 694427003419 NAD binding site [chemical binding]; other site 694427003420 substrate binding site [chemical binding]; other site 694427003421 homodimer interface [polypeptide binding]; other site 694427003422 active site 694427003423 Predicted permeases [General function prediction only]; Region: COG0795 694427003424 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 694427003425 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 694427003426 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 694427003427 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 694427003428 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 694427003429 putative active site [active] 694427003430 oxyanion strand; other site 694427003431 catalytic triad [active] 694427003432 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 694427003433 tetramerization interface [polypeptide binding]; other site 694427003434 active site 694427003435 Pantoate-beta-alanine ligase; Region: PanC; cd00560 694427003436 pantoate--beta-alanine ligase; Region: panC; TIGR00018 694427003437 active site 694427003438 ATP-binding site [chemical binding]; other site 694427003439 pantoate-binding site; other site 694427003440 HXXH motif; other site 694427003441 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 694427003442 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 694427003443 GTP-binding protein Der; Reviewed; Region: PRK00093 694427003444 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 694427003445 G1 box; other site 694427003446 GTP/Mg2+ binding site [chemical binding]; other site 694427003447 Switch I region; other site 694427003448 G2 box; other site 694427003449 Switch II region; other site 694427003450 G3 box; other site 694427003451 G4 box; other site 694427003452 G5 box; other site 694427003453 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 694427003454 G1 box; other site 694427003455 GTP/Mg2+ binding site [chemical binding]; other site 694427003456 Switch I region; other site 694427003457 G2 box; other site 694427003458 G3 box; other site 694427003459 Switch II region; other site 694427003460 G4 box; other site 694427003461 G5 box; other site 694427003462 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427003463 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 694427003464 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427003465 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 694427003466 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 694427003467 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427003468 Walker A motif; other site 694427003469 ATP binding site [chemical binding]; other site 694427003470 Walker B motif; other site 694427003471 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 694427003472 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 694427003473 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 694427003474 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 694427003475 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 694427003476 dimer interface [polypeptide binding]; other site 694427003477 decamer (pentamer of dimers) interface [polypeptide binding]; other site 694427003478 catalytic triad [active] 694427003479 peroxidatic and resolving cysteines [active] 694427003480 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 694427003481 homotrimer interaction site [polypeptide binding]; other site 694427003482 zinc binding site [ion binding]; other site 694427003483 CDP-binding sites; other site 694427003484 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 694427003485 active site 694427003486 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 694427003487 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 694427003488 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 694427003489 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 694427003490 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 694427003491 CoA binding domain; Region: CoA_binding; pfam02629 694427003492 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 694427003493 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427003494 active site 694427003495 HIGH motif; other site 694427003496 nucleotide binding site [chemical binding]; other site 694427003497 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427003498 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 694427003499 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427003500 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427003501 active site 694427003502 KMSKS motif; other site 694427003503 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 694427003504 tRNA binding surface [nucleotide binding]; other site 694427003505 anticodon binding site; other site 694427003506 Uncharacterized conserved protein [Function unknown]; Region: COG1284 694427003507 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 694427003508 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 694427003509 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 694427003510 colanic acid exporter; Provisional; Region: PRK10459 694427003511 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 694427003512 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 694427003513 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427003514 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 694427003515 GDP-Fucose binding site [chemical binding]; other site 694427003516 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 694427003517 GDP-Fucose binding site [chemical binding]; other site 694427003518 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694427003519 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 694427003520 active site 694427003521 Methyltransferase domain; Region: Methyltransf_23; pfam13489 694427003522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427003523 S-adenosylmethionine binding site [chemical binding]; other site 694427003524 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 694427003525 active site 694427003526 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 694427003527 homodimer interface [polypeptide binding]; other site 694427003528 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 694427003529 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427003530 Methyltransferase domain; Region: Methyltransf_23; pfam13489 694427003531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427003532 S-adenosylmethionine binding site [chemical binding]; other site 694427003533 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 694427003534 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 694427003535 HIGH motif; other site 694427003536 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 694427003537 active site 694427003538 KMSKS motif; other site 694427003539 elongation factor Ts; Provisional; Region: tsf; PRK09377 694427003540 UBA/TS-N domain; Region: UBA; pfam00627 694427003541 Elongation factor TS; Region: EF_TS; pfam00889 694427003542 Elongation factor TS; Region: EF_TS; pfam00889 694427003543 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 694427003544 rRNA interaction site [nucleotide binding]; other site 694427003545 S8 interaction site; other site 694427003546 putative laminin-1 binding site; other site 694427003547 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 694427003548 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 694427003549 23S rRNA interface [nucleotide binding]; other site 694427003550 L3 interface [polypeptide binding]; other site 694427003551 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 694427003552 active site 694427003553 DNA binding site [nucleotide binding] 694427003554 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427003555 Walker A/P-loop; other site 694427003556 ATP binding site [chemical binding]; other site 694427003557 Q-loop/lid; other site 694427003558 ABC transporter signature motif; other site 694427003559 Walker B; other site 694427003560 D-loop; other site 694427003561 H-loop/switch region; other site 694427003562 Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087 694427003563 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340 694427003564 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 694427003565 Ca binding site [ion binding]; other site 694427003566 active site 694427003567 homodimer interface [polypeptide binding]; other site 694427003568 catalytic site [active] 694427003569 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 694427003570 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 694427003571 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 694427003572 putative catalytic site [active] 694427003573 metal binding site A [ion binding]; metal-binding site 694427003574 phosphate binding site [ion binding]; other site 694427003575 metal binding site C [ion binding]; metal-binding site 694427003576 metal binding site B [ion binding]; metal-binding site 694427003577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 694427003578 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 694427003579 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 694427003580 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 694427003581 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 694427003582 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 694427003583 active site 694427003584 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427003585 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427003586 catalytic residues [active] 694427003587 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 694427003588 active site 694427003589 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 694427003590 dimer interface [polypeptide binding]; other site 694427003591 FMN binding site [chemical binding]; other site 694427003592 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 694427003593 dimer interface [polypeptide binding]; other site 694427003594 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 694427003595 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 694427003596 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 694427003597 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427003598 RibD C-terminal domain; Region: RibD_C; cl17279 694427003599 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 694427003600 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 694427003601 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 694427003602 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 694427003603 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 694427003604 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 694427003605 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 694427003606 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694427003607 active site 694427003608 motif I; other site 694427003609 motif II; other site 694427003610 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 694427003611 putative active site pocket [active] 694427003612 4-fold oligomerization interface [polypeptide binding]; other site 694427003613 metal binding residues [ion binding]; metal-binding site 694427003614 3-fold/trimer interface [polypeptide binding]; other site 694427003615 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 694427003616 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 694427003617 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694427003618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427003619 homodimer interface [polypeptide binding]; other site 694427003620 catalytic residue [active] 694427003621 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 694427003622 ligand binding site [chemical binding]; other site 694427003623 active site 694427003624 UGI interface [polypeptide binding]; other site 694427003625 catalytic site [active] 694427003626 Uncharacterized conserved protein [Function unknown]; Region: COG2966 694427003627 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 694427003628 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 694427003629 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 694427003630 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 694427003631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427003632 Walker A motif; other site 694427003633 ATP binding site [chemical binding]; other site 694427003634 Walker B motif; other site 694427003635 arginine finger; other site 694427003636 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 694427003637 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 694427003638 Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; cl17112 694427003639 Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; cl17112 694427003640 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 694427003641 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 694427003642 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 694427003643 Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; cl03910 694427003644 nitrogenase iron-iron protein, alpha chain; Region: ANFD; TIGR01861 694427003645 Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of, the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977 694427003646 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 694427003647 Nitrogen regulatory protein P-II; Region: P-II; smart00938 694427003648 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 694427003649 Nitrogen regulatory protein P-II; Region: P-II; smart00938 694427003650 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 694427003651 nitrogenase iron protein; Region: nifH; TIGR01287 694427003652 Nucleotide-binding sites [chemical binding]; other site 694427003653 Walker A motif; other site 694427003654 Switch I region of nucleotide binding site; other site 694427003655 Fe4S4 binding sites [ion binding]; other site 694427003656 Switch II region of nucleotide binding site; other site 694427003657 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 694427003658 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 694427003659 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 694427003660 putative active site [active] 694427003661 catalytic site [active] 694427003662 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 694427003663 putative active site [active] 694427003664 catalytic site [active] 694427003665 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 694427003666 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 694427003667 catalytic motif [active] 694427003668 Zn binding site [ion binding]; other site 694427003669 RibD C-terminal domain; Region: RibD_C; cl17279 694427003670 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 694427003671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427003672 S-adenosylmethionine binding site [chemical binding]; other site 694427003673 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 694427003674 EamA-like transporter family; Region: EamA; pfam00892 694427003675 EamA-like transporter family; Region: EamA; pfam00892 694427003676 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 694427003677 RecX family; Region: RecX; pfam02631 694427003678 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 694427003679 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 694427003680 tRNA-specific 2-thiouridylase MnmA; Provisional; Region: mnmA; PRK14665 694427003681 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 694427003682 Ligand Binding Site [chemical binding]; other site 694427003683 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 694427003684 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 694427003685 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PTZ00023 694427003686 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 694427003687 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 694427003688 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 694427003689 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 694427003690 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 694427003691 active site 694427003692 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 694427003693 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 694427003694 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 694427003695 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 694427003696 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 694427003697 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 694427003698 TfoX C-terminal domain; Region: TfoX_C; pfam04994 694427003699 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 694427003700 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 694427003701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427003702 Coenzyme A binding pocket [chemical binding]; other site 694427003703 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 694427003704 putative active site [active] 694427003705 putative catalytic site [active] 694427003706 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 694427003707 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 694427003708 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 694427003709 Uncharacterized conserved protein [Function unknown]; Region: COG2006 694427003710 Domain of unknown function (DUF362); Region: DUF362; pfam04015 694427003711 4Fe-4S binding domain; Region: Fer4_5; pfam12801 694427003712 4Fe-4S binding domain; Region: Fer4_5; pfam12801 694427003713 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 694427003714 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 694427003715 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 694427003716 LysE type translocator; Region: LysE; cl00565 694427003717 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 694427003718 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 694427003719 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427003720 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427003721 DNA binding residues [nucleotide binding] 694427003722 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 694427003723 NlpC/P60 family; Region: NLPC_P60; pfam00877 694427003724 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 694427003725 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 694427003726 Zn2+ binding site [ion binding]; other site 694427003727 Mg2+ binding site [ion binding]; other site 694427003728 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427003729 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 694427003730 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427003731 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 694427003732 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 694427003733 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694427003734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427003735 homodimer interface [polypeptide binding]; other site 694427003736 catalytic residue [active] 694427003737 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 694427003738 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 694427003739 acyl-activating enzyme (AAE) consensus motif; other site 694427003740 AMP binding site [chemical binding]; other site 694427003741 active site 694427003742 CoA binding site [chemical binding]; other site 694427003743 ACT domain-containing protein [General function prediction only]; Region: COG4747 694427003744 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 694427003745 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 694427003746 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 694427003747 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427003748 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427003749 DNA binding residues [nucleotide binding] 694427003750 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 694427003751 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 694427003752 NAD binding site [chemical binding]; other site 694427003753 Rop-like; Region: Rop-like; cl02247 694427003754 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 694427003755 ArsC family; Region: ArsC; pfam03960 694427003756 putative catalytic residues [active] 694427003757 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 694427003758 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 694427003759 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427003760 ligand binding site [chemical binding]; other site 694427003761 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 694427003762 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 694427003763 CoA-ligase; Region: Ligase_CoA; pfam00549 694427003764 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 694427003765 CoA binding domain; Region: CoA_binding; smart00881 694427003766 CoA-ligase; Region: Ligase_CoA; pfam00549 694427003767 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 694427003768 molybdenum-pterin binding domain; Region: Mop; TIGR00638 694427003769 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 694427003770 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 694427003771 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 694427003772 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 694427003773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694427003774 dimer interface [polypeptide binding]; other site 694427003775 conserved gate region; other site 694427003776 putative PBP binding loops; other site 694427003777 ABC-ATPase subunit interface; other site 694427003778 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 694427003779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427003780 Walker A/P-loop; other site 694427003781 ATP binding site [chemical binding]; other site 694427003782 Q-loop/lid; other site 694427003783 ABC transporter signature motif; other site 694427003784 Walker B; other site 694427003785 D-loop; other site 694427003786 H-loop/switch region; other site 694427003787 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 694427003788 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 694427003789 Nucleotide-binding sites [chemical binding]; other site 694427003790 Walker A motif; other site 694427003791 Switch I region of nucleotide binding site; other site 694427003792 Fe4S4 binding sites [ion binding]; other site 694427003793 Switch II region of nucleotide binding site; other site 694427003794 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 694427003795 Nitrogen regulatory protein P-II; Region: P-II; smart00938 694427003796 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 694427003797 Nitrogen regulatory protein P-II; Region: P-II; smart00938 694427003798 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 694427003799 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 694427003800 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 694427003801 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 694427003802 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 694427003803 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 694427003804 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 694427003805 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 694427003806 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 694427003807 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427003808 FeS/SAM binding site; other site 694427003809 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 694427003810 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 694427003811 dimer interface [polypeptide binding]; other site 694427003812 [2Fe-2S] cluster binding site [ion binding]; other site 694427003813 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 694427003814 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 694427003815 active site 694427003816 catalytic residues [active] 694427003817 metal binding site [ion binding]; metal-binding site 694427003818 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 694427003819 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 694427003820 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 694427003821 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427003822 Coenzyme A binding pocket [chemical binding]; other site 694427003823 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 694427003824 Nif-specific regulatory protein; Region: nifA; TIGR01817 694427003825 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 694427003826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427003827 Walker A motif; other site 694427003828 ATP binding site [chemical binding]; other site 694427003829 Walker B motif; other site 694427003830 arginine finger; other site 694427003831 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 694427003832 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 694427003833 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 694427003834 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 694427003835 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 694427003836 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14838 694427003837 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 694427003838 catalytic residue [active] 694427003839 putative FPP diphosphate binding site; other site 694427003840 putative FPP binding hydrophobic cleft; other site 694427003841 dimer interface [polypeptide binding]; other site 694427003842 putative IPP diphosphate binding site; other site 694427003843 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 694427003844 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 694427003845 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 694427003846 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 694427003847 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 694427003848 Surface antigen; Region: Bac_surface_Ag; pfam01103 694427003849 periplasmic chaperone; Provisional; Region: PRK10780 694427003850 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 694427003851 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 694427003852 hypothetical protein; Provisional; Region: PRK10410 694427003853 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 694427003854 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 694427003855 DNA binding residues [nucleotide binding] 694427003856 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 694427003857 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 694427003858 N-acetyl-D-glucosamine binding site [chemical binding]; other site 694427003859 catalytic residue [active] 694427003860 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 694427003861 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 694427003862 ParB-like nuclease domain; Region: ParB; smart00470 694427003863 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 694427003864 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 694427003865 P-loop; other site 694427003866 Magnesium ion binding site [ion binding]; other site 694427003867 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 694427003868 Magnesium ion binding site [ion binding]; other site 694427003869 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 694427003870 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427003871 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427003872 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 694427003873 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427003874 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 694427003875 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427003876 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 694427003877 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 694427003878 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 694427003879 active site 694427003880 metal binding site [ion binding]; metal-binding site 694427003881 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 694427003882 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427003883 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427003884 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 694427003885 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 694427003886 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 694427003887 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 694427003888 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 694427003889 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 694427003890 putative NADH binding site [chemical binding]; other site 694427003891 putative active site [active] 694427003892 nudix motif; other site 694427003893 putative metal binding site [ion binding]; other site 694427003894 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 694427003895 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 694427003896 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 694427003897 G1 box; other site 694427003898 GTP/Mg2+ binding site [chemical binding]; other site 694427003899 Switch I region; other site 694427003900 G2 box; other site 694427003901 G3 box; other site 694427003902 Switch II region; other site 694427003903 G4 box; other site 694427003904 G5 box; other site 694427003905 Nucleoside recognition; Region: Gate; pfam07670 694427003906 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 694427003907 Nucleoside recognition; Region: Gate; pfam07670 694427003908 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 694427003909 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 694427003910 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 694427003911 DNA binding residues [nucleotide binding] 694427003912 dimerization interface [polypeptide binding]; other site 694427003913 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 694427003914 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 694427003915 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 694427003916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427003917 Walker A motif; other site 694427003918 ATP binding site [chemical binding]; other site 694427003919 Walker B motif; other site 694427003920 arginine finger; other site 694427003921 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 694427003922 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 694427003923 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 694427003924 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 694427003925 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 694427003926 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 694427003927 nudix motif; other site 694427003928 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 694427003929 Lumazine binding domain; Region: Lum_binding; pfam00677 694427003930 Lumazine binding domain; Region: Lum_binding; pfam00677 694427003931 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 694427003932 HD domain; Region: HD_4; pfam13328 694427003933 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 694427003934 synthetase active site [active] 694427003935 NTP binding site [chemical binding]; other site 694427003936 metal binding site [ion binding]; metal-binding site 694427003937 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 694427003938 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 694427003939 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 694427003940 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 694427003941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427003942 S-adenosylmethionine binding site [chemical binding]; other site 694427003943 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 694427003944 N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme); Region: E_set_GBE_euk_N; cd02854 694427003945 Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321 694427003946 active site 694427003947 catalytic site [active] 694427003948 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 694427003949 Domain of unknown function (DUF386); Region: DUF386; cl01047 694427003950 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 694427003951 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 694427003952 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 694427003953 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 694427003954 dimer interface [polypeptide binding]; other site 694427003955 motif 1; other site 694427003956 active site 694427003957 motif 2; other site 694427003958 motif 3; other site 694427003959 TPR repeat; Region: TPR_11; pfam13414 694427003960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427003961 binding surface 694427003962 TPR motif; other site 694427003963 TPR repeat; Region: TPR_11; pfam13414 694427003964 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427003965 binding surface 694427003966 TPR motif; other site 694427003967 TPR repeat; Region: TPR_11; pfam13414 694427003968 TPR repeat; Region: TPR_11; pfam13414 694427003969 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427003970 binding surface 694427003971 TPR motif; other site 694427003972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 694427003973 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 694427003974 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 694427003975 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 694427003976 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 694427003977 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 694427003978 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 694427003979 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 694427003980 Interdomain contacts; other site 694427003981 Cytokine receptor motif; other site 694427003982 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14466 694427003983 SurA N-terminal domain; Region: SurA_N_3; cl07813 694427003984 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 694427003985 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 694427003986 Domain of unknown function DUF21; Region: DUF21; pfam01595 694427003987 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 694427003988 Transporter associated domain; Region: CorC_HlyC; smart01091 694427003989 Yqey-like protein; Region: YqeY; pfam09424 694427003990 cell division protein FtsZ; Validated; Region: PRK09330 694427003991 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 694427003992 nucleotide binding site [chemical binding]; other site 694427003993 SulA interaction site; other site 694427003994 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 694427003995 Cell division protein FtsA; Region: FtsA; cl17206 694427003996 Cell division protein FtsA; Region: FtsA; pfam14450 694427003997 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 694427003998 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 694427003999 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 694427004000 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 694427004001 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 694427004002 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 694427004003 active site 694427004004 homodimer interface [polypeptide binding]; other site 694427004005 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 694427004006 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 694427004007 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 694427004008 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 694427004009 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 694427004010 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 694427004011 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 694427004012 Mg++ binding site [ion binding]; other site 694427004013 putative catalytic motif [active] 694427004014 putative substrate binding site [chemical binding]; other site 694427004015 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 694427004016 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 694427004017 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 694427004018 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 694427004019 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 694427004020 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 694427004021 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 694427004022 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 694427004023 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 694427004024 MraW methylase family; Region: Methyltransf_5; cl17771 694427004025 cell division protein MraZ; Reviewed; Region: PRK00326 694427004026 MraZ protein; Region: MraZ; pfam02381 694427004027 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 694427004028 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 694427004029 putative acyl-acceptor binding pocket; other site 694427004030 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 694427004031 Coenzyme A binding pocket [chemical binding]; other site 694427004032 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 694427004033 RimM N-terminal domain; Region: RimM; pfam01782 694427004034 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 694427004035 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 694427004036 homodimer interface [polypeptide binding]; other site 694427004037 substrate-cofactor binding pocket; other site 694427004038 catalytic residue [active] 694427004039 WbqC-like protein family; Region: WbqC; pfam08889 694427004040 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 694427004041 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 694427004042 dihydrodipicolinate reductase; Provisional; Region: PRK00048 694427004043 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 694427004044 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 694427004045 CoA binding domain; Region: CoA_binding_2; pfam13380 694427004046 NADH(P)-binding; Region: NAD_binding_10; pfam13460 694427004047 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 694427004048 active site 694427004049 dimer interface [polypeptide binding]; other site 694427004050 metal binding site [ion binding]; metal-binding site 694427004051 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 694427004052 dimerization interface [polypeptide binding]; other site 694427004053 putative DNA binding site [nucleotide binding]; other site 694427004054 putative Zn2+ binding site [ion binding]; other site 694427004055 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 694427004056 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427004057 catalytic residues [active] 694427004058 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 694427004059 Chorismate mutase type II; Region: CM_2; smart00830 694427004060 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 694427004061 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694427004062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427004063 homodimer interface [polypeptide binding]; other site 694427004064 catalytic residue [active] 694427004065 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 694427004066 Prephenate dehydratase; Region: PDT; pfam00800 694427004067 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 694427004068 putative L-Phe binding site [chemical binding]; other site 694427004069 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 694427004070 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 694427004071 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 694427004072 DNA binding site [nucleotide binding] 694427004073 active site 694427004074 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 694427004075 acyl-activating enzyme (AAE) consensus motif; other site 694427004076 AMP binding site [chemical binding]; other site 694427004077 active site 694427004078 CoA binding site [chemical binding]; other site 694427004079 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 694427004080 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 694427004081 active site 694427004082 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 694427004083 UbiA prenyltransferase family; Region: UbiA; pfam01040 694427004084 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 694427004085 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 694427004086 substrate binding site [chemical binding]; other site 694427004087 oxyanion hole (OAH) forming residues; other site 694427004088 trimer interface [polypeptide binding]; other site 694427004089 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 694427004090 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 694427004091 dimer interface [polypeptide binding]; other site 694427004092 tetramer interface [polypeptide binding]; other site 694427004093 PYR/PP interface [polypeptide binding]; other site 694427004094 TPP binding site [chemical binding]; other site 694427004095 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 694427004096 TPP-binding site; other site 694427004097 chorismate binding enzyme; Region: Chorismate_bind; cl10555 694427004098 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 694427004099 CoenzymeA binding site [chemical binding]; other site 694427004100 subunit interaction site [polypeptide binding]; other site 694427004101 PHB binding site; other site 694427004102 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 694427004103 active site 694427004104 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427004105 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 694427004106 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 694427004107 Peptidase family C69; Region: Peptidase_C69; cl17793 694427004108 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 694427004109 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 694427004110 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 694427004111 LytTr DNA-binding domain; Region: LytTR; smart00850 694427004112 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 694427004113 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427004114 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 694427004115 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 694427004116 Domain of unknown function (DUF2027); Region: DUF2027; pfam09640 694427004117 Smr domain; Region: Smr; pfam01713 694427004118 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 694427004119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427004120 active site 694427004121 phosphorylation site [posttranslational modification] 694427004122 intermolecular recognition site; other site 694427004123 dimerization interface [polypeptide binding]; other site 694427004124 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694427004125 DNA binding site [nucleotide binding] 694427004126 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 694427004127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427004128 dimer interface [polypeptide binding]; other site 694427004129 phosphorylation site [posttranslational modification] 694427004130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427004131 ATP binding site [chemical binding]; other site 694427004132 Mg2+ binding site [ion binding]; other site 694427004133 G-X-G motif; other site 694427004134 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 694427004135 K+ potassium transporter; Region: K_trans; cl15781 694427004136 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 694427004137 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 694427004138 PAS domain S-box; Region: sensory_box; TIGR00229 694427004139 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427004140 putative active site [active] 694427004141 heme pocket [chemical binding]; other site 694427004142 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 694427004143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427004144 ATP binding site [chemical binding]; other site 694427004145 Mg2+ binding site [ion binding]; other site 694427004146 G-X-G motif; other site 694427004147 GMP synthase; Reviewed; Region: guaA; PRK00074 694427004148 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 694427004149 AMP/PPi binding site [chemical binding]; other site 694427004150 candidate oxyanion hole; other site 694427004151 catalytic triad [active] 694427004152 potential glutamine specificity residues [chemical binding]; other site 694427004153 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 694427004154 ATP Binding subdomain [chemical binding]; other site 694427004155 Ligand Binding sites [chemical binding]; other site 694427004156 Dimerization subdomain; other site 694427004157 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 694427004158 active site 694427004159 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 694427004160 Outer membrane efflux protein; Region: OEP; pfam02321 694427004161 Outer membrane efflux protein; Region: OEP; pfam02321 694427004162 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 694427004163 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427004164 HlyD family secretion protein; Region: HlyD_3; pfam13437 694427004165 Domain of unknown function (DUF4221); Region: DUF4221; pfam13970 694427004166 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 694427004167 O-Antigen ligase; Region: Wzy_C; pfam04932 694427004168 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427004169 binding surface 694427004170 TPR motif; other site 694427004171 TPR repeat; Region: TPR_11; pfam13414 694427004172 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 694427004173 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 694427004174 Catalytic site [active] 694427004175 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 694427004176 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 694427004177 NVEALA protein; Region: NVEALA; pfam14055 694427004178 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 694427004179 putative sugar binding sites [chemical binding]; other site 694427004180 Q-X-W motif; other site 694427004181 NVEALA protein; Region: NVEALA; pfam14055 694427004182 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 694427004183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427004184 ATP binding site [chemical binding]; other site 694427004185 Mg2+ binding site [ion binding]; other site 694427004186 G-X-G motif; other site 694427004187 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 694427004188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427004189 active site 694427004190 phosphorylation site [posttranslational modification] 694427004191 intermolecular recognition site; other site 694427004192 dimerization interface [polypeptide binding]; other site 694427004193 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694427004194 DNA binding site [nucleotide binding] 694427004195 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694427004196 non-specific DNA binding site [nucleotide binding]; other site 694427004197 salt bridge; other site 694427004198 sequence-specific DNA binding site [nucleotide binding]; other site 694427004199 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 694427004200 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 694427004201 putative active site [active] 694427004202 putative metal binding site [ion binding]; other site 694427004203 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 694427004204 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 694427004205 CHC2 zinc finger; Region: zf-CHC2; cl17510 694427004206 Toprim-like; Region: Toprim_2; pfam13155 694427004207 Virulence-associated protein E; Region: VirE; pfam05272 694427004208 Protein of unknown function (DUF3853); Region: DUF3853; pfam12964 694427004209 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 694427004210 active site 694427004211 DNA binding site [nucleotide binding] 694427004212 Int/Topo IB signature motif; other site 694427004213 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 694427004214 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 694427004215 dimer interface [polypeptide binding]; other site 694427004216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427004217 catalytic residue [active] 694427004218 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 694427004219 thiS-thiF/thiG interaction site; other site 694427004220 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 694427004221 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 694427004222 ATP binding site [chemical binding]; other site 694427004223 substrate interface [chemical binding]; other site 694427004224 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 694427004225 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 694427004226 CPxP motif; other site 694427004227 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 694427004228 MPN+ (JAMM) motif; other site 694427004229 Zinc-binding site [ion binding]; other site 694427004230 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 694427004231 serine O-acetyltransferase; Region: cysE; TIGR01172 694427004232 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 694427004233 trimer interface [polypeptide binding]; other site 694427004234 active site 694427004235 substrate binding site [chemical binding]; other site 694427004236 CoA binding site [chemical binding]; other site 694427004237 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 694427004238 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 694427004239 ligand binding site [chemical binding]; other site 694427004240 flexible hinge region; other site 694427004241 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 694427004242 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 694427004243 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694427004244 catalytic residue [active] 694427004245 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 694427004246 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427004247 Coenzyme A binding pocket [chemical binding]; other site 694427004248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427004249 Coenzyme A binding pocket [chemical binding]; other site 694427004250 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 694427004251 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 694427004252 PBP superfamily domain; Region: PBP_like_2; cl17296 694427004253 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427004254 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427004255 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 694427004256 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 694427004257 starch binding outer membrane protein SusD; Region: SusD; cl17845 694427004258 SusD family; Region: SusD; pfam07980 694427004259 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 694427004260 Sulfatase; Region: Sulfatase; pfam00884 694427004261 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 694427004262 Sulfatase; Region: Sulfatase; pfam00884 694427004263 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 694427004264 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 694427004265 Uncharacterized conserved protein [Function unknown]; Region: COG5361 694427004266 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 694427004267 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 694427004268 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 694427004269 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 694427004270 dimer interface [polypeptide binding]; other site 694427004271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427004272 catalytic residue [active] 694427004273 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 694427004274 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 694427004275 homodimer interface [polypeptide binding]; other site 694427004276 substrate-cofactor binding pocket; other site 694427004277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427004278 catalytic residue [active] 694427004279 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427004280 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427004281 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 694427004282 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427004283 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 694427004284 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427004285 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 694427004286 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427004287 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427004288 catalytic residues [active] 694427004289 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 694427004290 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 694427004291 DNA binding residues [nucleotide binding] 694427004292 dimerization interface [polypeptide binding]; other site 694427004293 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 694427004294 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427004295 FeS/SAM binding site; other site 694427004296 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 694427004297 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 694427004298 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 694427004299 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 694427004300 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 694427004301 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 694427004302 CPxP motif; other site 694427004303 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 694427004304 active site 694427004305 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 694427004306 metal binding site [ion binding]; metal-binding site 694427004307 ligand binding site [chemical binding]; other site 694427004308 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 694427004309 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 694427004310 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 694427004311 putative active site [active] 694427004312 putative catalytic site [active] 694427004313 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 694427004314 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 694427004315 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 694427004316 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 694427004317 putative active site [active] 694427004318 putative catalytic site [active] 694427004319 alpha-galactosidase; Region: PLN02808; cl17638 694427004320 NPCBM/NEW2 domain; Region: NPCBM; cl07060 694427004321 NPCBM/NEW2 domain; Region: NPCBM; cl07060 694427004322 beta-D-glucuronidase; Provisional; Region: PRK10150 694427004323 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 694427004324 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 694427004325 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 694427004326 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 694427004327 substrate binding site [chemical binding]; other site 694427004328 active site 694427004329 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 694427004330 metal binding site [ion binding]; metal-binding site 694427004331 ligand binding site [chemical binding]; other site 694427004332 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 694427004333 active site 694427004334 substrate binding site [chemical binding]; other site 694427004335 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 694427004336 active site 694427004337 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 694427004338 metal binding site [ion binding]; metal-binding site 694427004339 ligand binding site [chemical binding]; other site 694427004340 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 694427004341 Putative Ig domain; Region: He_PIG; pfam05345 694427004342 alpha-galactosidase; Region: PLN02808; cl17638 694427004343 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 694427004344 substrate binding site [chemical binding]; other site 694427004345 active site 694427004346 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 694427004347 metal binding site [ion binding]; metal-binding site 694427004348 ligand binding site [chemical binding]; other site 694427004349 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 694427004350 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 694427004351 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 694427004352 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 694427004353 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 694427004354 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 694427004355 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 694427004356 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 694427004357 ligand binding site [chemical binding]; other site 694427004358 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 694427004359 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 694427004360 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 694427004361 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 694427004362 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 694427004363 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 694427004364 PA14 domain; Region: PA14; cl08459 694427004365 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 694427004366 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 694427004367 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 694427004368 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 694427004369 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427004370 dimer interface [polypeptide binding]; other site 694427004371 phosphorylation site [posttranslational modification] 694427004372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427004373 ATP binding site [chemical binding]; other site 694427004374 Mg2+ binding site [ion binding]; other site 694427004375 G-X-G motif; other site 694427004376 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 694427004377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427004378 active site 694427004379 phosphorylation site [posttranslational modification] 694427004380 intermolecular recognition site; other site 694427004381 dimerization interface [polypeptide binding]; other site 694427004382 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 694427004383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427004384 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 694427004385 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 694427004386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427004387 Domain of unknown function (DUF303); Region: DUF303; pfam03629 694427004388 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 694427004389 Domain of unknown function (DUF303); Region: DUF303; pfam03629 694427004390 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 694427004391 Domain of unknown function (DUF303); Region: DUF303; pfam03629 694427004392 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 694427004393 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 694427004394 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 694427004395 Putative esterase; Region: Esterase; pfam00756 694427004396 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 694427004397 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 694427004398 Putative esterase; Region: Esterase; pfam00756 694427004399 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 694427004400 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 694427004401 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 694427004402 Putative esterase; Region: Esterase; pfam00756 694427004403 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 694427004404 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 694427004405 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 694427004406 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 694427004407 Putative esterase; Region: Esterase; pfam00756 694427004408 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 694427004409 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 694427004410 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 694427004411 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 694427004412 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 694427004413 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 694427004414 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 694427004415 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 694427004416 substrate binding site [chemical binding]; other site 694427004417 active site 694427004418 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 694427004419 ligand binding site [chemical binding]; other site 694427004420 metal binding site [ion binding]; metal-binding site 694427004421 alpha-galactosidase; Region: PLN02808; cl17638 694427004422 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 694427004423 Ca binding site [ion binding]; other site 694427004424 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 694427004425 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 694427004426 active site 694427004427 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 694427004428 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 694427004429 active site 694427004430 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 694427004431 sugar binding site [chemical binding]; other site 694427004432 Carboxylesterase family; Region: COesterase; pfam00135 694427004433 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 694427004434 substrate binding pocket [chemical binding]; other site 694427004435 catalytic triad [active] 694427004436 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 694427004437 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 694427004438 inhibitor binding site; inhibition site 694427004439 active site 694427004440 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 694427004441 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 694427004442 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 694427004443 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 694427004444 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 694427004445 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 694427004446 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 694427004447 RNase E interface [polypeptide binding]; other site 694427004448 trimer interface [polypeptide binding]; other site 694427004449 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 694427004450 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 694427004451 RNase E interface [polypeptide binding]; other site 694427004452 trimer interface [polypeptide binding]; other site 694427004453 active site 694427004454 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 694427004455 putative nucleic acid binding region [nucleotide binding]; other site 694427004456 G-X-X-G motif; other site 694427004457 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 694427004458 RNA binding site [nucleotide binding]; other site 694427004459 domain interface; other site 694427004460 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 694427004461 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 694427004462 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 694427004463 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 694427004464 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 694427004465 FAD binding site [chemical binding]; other site 694427004466 short chain dehydrogenase; Provisional; Region: PRK06197 694427004467 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 694427004468 putative NAD(P) binding site [chemical binding]; other site 694427004469 active site 694427004470 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 694427004471 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 694427004472 lipoprotein signal peptidase; Provisional; Region: PRK14787 694427004473 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 694427004474 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 694427004475 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427004476 active site 694427004477 HIGH motif; other site 694427004478 nucleotide binding site [chemical binding]; other site 694427004479 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427004480 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427004481 active site 694427004482 KMSKS motif; other site 694427004483 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 694427004484 tRNA binding surface [nucleotide binding]; other site 694427004485 anticodon binding site; other site 694427004486 Protein of unknown function DUF262; Region: DUF262; pfam03235 694427004487 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 694427004488 active site 694427004489 heat shock protein 90; Provisional; Region: PRK05218 694427004490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427004491 ATP binding site [chemical binding]; other site 694427004492 Mg2+ binding site [ion binding]; other site 694427004493 G-X-G motif; other site 694427004494 Chorismate mutase type II; Region: CM_2; cl00693 694427004495 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 694427004496 active site 694427004497 catalytic residues [active] 694427004498 metal binding site [ion binding]; metal-binding site 694427004499 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 694427004500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427004501 ATP binding site [chemical binding]; other site 694427004502 Mg2+ binding site [ion binding]; other site 694427004503 G-X-G motif; other site 694427004504 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 694427004505 anchoring element; other site 694427004506 dimer interface [polypeptide binding]; other site 694427004507 ATP binding site [chemical binding]; other site 694427004508 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 694427004509 active site 694427004510 putative metal-binding site [ion binding]; other site 694427004511 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 694427004512 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 694427004513 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 694427004514 active site 694427004515 catalytic residues [active] 694427004516 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 694427004517 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 694427004518 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 694427004519 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 694427004520 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 694427004521 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 694427004522 putative active site [active] 694427004523 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 694427004524 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427004525 FeS/SAM binding site; other site 694427004526 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 694427004527 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 694427004528 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 694427004529 metal binding site [ion binding]; metal-binding site 694427004530 dimer interface [polypeptide binding]; other site 694427004531 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 694427004532 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 694427004533 PAS fold; Region: PAS_3; pfam08447 694427004534 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 694427004535 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 694427004536 DNA binding residues [nucleotide binding] 694427004537 dimerization interface [polypeptide binding]; other site 694427004538 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 694427004539 nucleotide binding site [chemical binding]; other site 694427004540 N-acetyl-L-glutamate binding site [chemical binding]; other site 694427004541 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 694427004542 active site 694427004543 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 694427004544 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 694427004545 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 694427004546 Response regulator receiver domain; Region: Response_reg; pfam00072 694427004547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427004548 active site 694427004549 phosphorylation site [posttranslational modification] 694427004550 intermolecular recognition site; other site 694427004551 dimerization interface [polypeptide binding]; other site 694427004552 PglZ domain; Region: PglZ; pfam08665 694427004553 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 694427004554 CAAX protease self-immunity; Region: Abi; pfam02517 694427004555 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 694427004556 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 694427004557 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 694427004558 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 694427004559 putative catalytic cysteine [active] 694427004560 gamma-glutamyl kinase; Provisional; Region: PRK05429 694427004561 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 694427004562 nucleotide binding site [chemical binding]; other site 694427004563 homotetrameric interface [polypeptide binding]; other site 694427004564 putative phosphate binding site [ion binding]; other site 694427004565 putative allosteric binding site; other site 694427004566 PUA domain; Region: PUA; pfam01472 694427004567 M28 Zn-Peptidases; Region: M28_like_6; cd08656 694427004568 Peptidase family M28; Region: Peptidase_M28; pfam04389 694427004569 metal binding site [ion binding]; metal-binding site 694427004570 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 694427004571 Ligand binding site [chemical binding]; other site 694427004572 Electron transfer flavoprotein domain; Region: ETF; pfam01012 694427004573 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 694427004574 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 694427004575 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 694427004576 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 694427004577 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 694427004578 active site 694427004579 Acyl-CoA dehydrogenase C terminal; Region: AcylCoA_dehyd_C; pfam12186 694427004580 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 694427004581 DNA-binding site [nucleotide binding]; DNA binding site 694427004582 RNA-binding motif; other site 694427004583 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 694427004584 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 694427004585 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 694427004586 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 694427004587 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427004588 Coenzyme A binding pocket [chemical binding]; other site 694427004589 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 694427004590 NAD-dependent deacetylase; Provisional; Region: PRK00481 694427004591 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 694427004592 NAD+ binding site [chemical binding]; other site 694427004593 substrate binding site [chemical binding]; other site 694427004594 Zn binding site [ion binding]; other site 694427004595 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 694427004596 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 694427004597 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 694427004598 active site 694427004599 DNA binding site [nucleotide binding] 694427004600 Int/Topo IB signature motif; other site 694427004601 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 694427004602 30S subunit binding site; other site 694427004603 elongation factor Tu; Reviewed; Region: PRK12735 694427004604 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 694427004605 G1 box; other site 694427004606 GEF interaction site [polypeptide binding]; other site 694427004607 GTP/Mg2+ binding site [chemical binding]; other site 694427004608 Switch I region; other site 694427004609 G2 box; other site 694427004610 G3 box; other site 694427004611 Switch II region; other site 694427004612 G4 box; other site 694427004613 G5 box; other site 694427004614 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 694427004615 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 694427004616 Antibiotic Binding Site [chemical binding]; other site 694427004617 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 694427004618 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 694427004619 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 694427004620 putative homodimer interface [polypeptide binding]; other site 694427004621 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 694427004622 heterodimer interface [polypeptide binding]; other site 694427004623 homodimer interface [polypeptide binding]; other site 694427004624 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 694427004625 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 694427004626 23S rRNA interface [nucleotide binding]; other site 694427004627 L7/L12 interface [polypeptide binding]; other site 694427004628 putative thiostrepton binding site; other site 694427004629 L25 interface [polypeptide binding]; other site 694427004630 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 694427004631 mRNA/rRNA interface [nucleotide binding]; other site 694427004632 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 694427004633 23S rRNA interface [nucleotide binding]; other site 694427004634 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 694427004635 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 694427004636 core dimer interface [polypeptide binding]; other site 694427004637 peripheral dimer interface [polypeptide binding]; other site 694427004638 L10 interface [polypeptide binding]; other site 694427004639 L11 interface [polypeptide binding]; other site 694427004640 putative EF-Tu interaction site [polypeptide binding]; other site 694427004641 putative EF-G interaction site [polypeptide binding]; other site 694427004642 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 694427004643 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 694427004644 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 694427004645 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 694427004646 RPB11 interaction site [polypeptide binding]; other site 694427004647 RPB12 interaction site [polypeptide binding]; other site 694427004648 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 694427004649 RPB3 interaction site [polypeptide binding]; other site 694427004650 RPB1 interaction site [polypeptide binding]; other site 694427004651 RPB11 interaction site [polypeptide binding]; other site 694427004652 RPB10 interaction site [polypeptide binding]; other site 694427004653 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 694427004654 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 694427004655 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 694427004656 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 694427004657 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 694427004658 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 694427004659 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 694427004660 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 694427004661 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 694427004662 DNA binding site [nucleotide binding] 694427004663 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 694427004664 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 694427004665 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 694427004666 Substrate binding site; other site 694427004667 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 694427004668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427004669 ATP binding site [chemical binding]; other site 694427004670 Mg2+ binding site [ion binding]; other site 694427004671 G-X-G motif; other site 694427004672 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 694427004673 ATP binding site [chemical binding]; other site 694427004674 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 694427004675 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 694427004676 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694427004677 motif II; other site 694427004678 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 694427004679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427004680 active site 694427004681 phosphorylation site [posttranslational modification] 694427004682 intermolecular recognition site; other site 694427004683 dimerization interface [polypeptide binding]; other site 694427004684 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694427004685 DNA binding site [nucleotide binding] 694427004686 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 694427004687 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427004688 dimer interface [polypeptide binding]; other site 694427004689 phosphorylation site [posttranslational modification] 694427004690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427004691 ATP binding site [chemical binding]; other site 694427004692 Mg2+ binding site [ion binding]; other site 694427004693 G-X-G motif; other site 694427004694 Methyltransferase domain; Region: Methyltransf_23; pfam13489 694427004695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427004696 S-adenosylmethionine binding site [chemical binding]; other site 694427004697 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 694427004698 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 694427004699 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 694427004700 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 694427004701 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427004702 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 694427004703 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 694427004704 OmpW family; Region: OmpW; cl17427 694427004705 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 694427004706 serpin-like protein; Provisional; Region: PHA02660 694427004707 reactive center loop; other site 694427004708 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 694427004709 Uncharacterized conserved protein [Function unknown]; Region: COG5276 694427004710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427004711 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 694427004712 NAD(P) binding site [chemical binding]; other site 694427004713 active site 694427004714 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 694427004715 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 694427004716 putative ligand binding site [chemical binding]; other site 694427004717 putative NAD binding site [chemical binding]; other site 694427004718 putative catalytic site [active] 694427004719 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 694427004720 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 694427004721 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694427004722 catalytic residue [active] 694427004723 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 694427004724 MutS domain I; Region: MutS_I; pfam01624 694427004725 MutS domain II; Region: MutS_II; pfam05188 694427004726 MutS domain III; Region: MutS_III; pfam05192 694427004727 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 694427004728 Walker A/P-loop; other site 694427004729 ATP binding site [chemical binding]; other site 694427004730 Q-loop/lid; other site 694427004731 ABC transporter signature motif; other site 694427004732 Walker B; other site 694427004733 D-loop; other site 694427004734 H-loop/switch region; other site 694427004735 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427004736 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 694427004737 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 694427004738 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 694427004739 phosphoglyceromutase; Provisional; Region: PRK05434 694427004740 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 694427004741 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 694427004742 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 694427004743 substrate binding pocket [chemical binding]; other site 694427004744 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 694427004745 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 694427004746 B12 binding site [chemical binding]; other site 694427004747 cobalt ligand [ion binding]; other site 694427004748 ORF6N domain; Region: ORF6N; pfam10543 694427004749 putative recombination protein RecB; Provisional; Region: PRK13909 694427004750 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 694427004751 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 694427004752 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 694427004753 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 694427004754 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 694427004755 domain interface [polypeptide binding]; other site 694427004756 active site 694427004757 catalytic site [active] 694427004758 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 694427004759 domain interface [polypeptide binding]; other site 694427004760 active site 694427004761 catalytic site [active] 694427004762 exopolyphosphatase; Region: exo_poly_only; TIGR03706 694427004763 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 694427004764 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427004765 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427004766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427004767 putative substrate translocation pore; other site 694427004768 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 694427004769 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 694427004770 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 694427004771 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 694427004772 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 694427004773 putative active site [active] 694427004774 putative metal binding site [ion binding]; other site 694427004775 PBP superfamily domain; Region: PBP_like_2; cl17296 694427004776 PBP superfamily domain; Region: PBP_like_2; pfam12849 694427004777 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 694427004778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694427004779 dimer interface [polypeptide binding]; other site 694427004780 conserved gate region; other site 694427004781 putative PBP binding loops; other site 694427004782 ABC-ATPase subunit interface; other site 694427004783 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 694427004784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694427004785 dimer interface [polypeptide binding]; other site 694427004786 conserved gate region; other site 694427004787 putative PBP binding loops; other site 694427004788 ABC-ATPase subunit interface; other site 694427004789 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 694427004790 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 694427004791 Walker A/P-loop; other site 694427004792 ATP binding site [chemical binding]; other site 694427004793 Q-loop/lid; other site 694427004794 ABC transporter signature motif; other site 694427004795 Walker B; other site 694427004796 D-loop; other site 694427004797 H-loop/switch region; other site 694427004798 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 694427004799 PhoU domain; Region: PhoU; pfam01895 694427004800 PhoU domain; Region: PhoU; pfam01895 694427004801 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 694427004802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427004803 active site 694427004804 phosphorylation site [posttranslational modification] 694427004805 intermolecular recognition site; other site 694427004806 dimerization interface [polypeptide binding]; other site 694427004807 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694427004808 DNA binding site [nucleotide binding] 694427004809 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 694427004810 HAMP domain; Region: HAMP; pfam00672 694427004811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427004812 dimer interface [polypeptide binding]; other site 694427004813 phosphorylation site [posttranslational modification] 694427004814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427004815 ATP binding site [chemical binding]; other site 694427004816 Mg2+ binding site [ion binding]; other site 694427004817 G-X-G motif; other site 694427004818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427004819 putative substrate translocation pore; other site 694427004820 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 694427004821 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 694427004822 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427004823 ligand binding site [chemical binding]; other site 694427004824 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 694427004825 G1 box; other site 694427004826 putative GEF interaction site [polypeptide binding]; other site 694427004827 GTP/Mg2+ binding site [chemical binding]; other site 694427004828 elongation factor G; Reviewed; Region: PRK12740 694427004829 Switch I region; other site 694427004830 G2 box; other site 694427004831 G3 box; other site 694427004832 Switch II region; other site 694427004833 G4 box; other site 694427004834 G5 box; other site 694427004835 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 694427004836 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 694427004837 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 694427004838 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 694427004839 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 694427004840 glycyl-tRNA synthetase; Provisional; Region: PRK04173 694427004841 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 694427004842 motif 1; other site 694427004843 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 694427004844 active site 694427004845 motif 2; other site 694427004846 motif 3; other site 694427004847 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 694427004848 anticodon binding site; other site 694427004849 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 694427004850 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 694427004851 CAP-like domain; other site 694427004852 active site 694427004853 primary dimer interface [polypeptide binding]; other site 694427004854 OstA-like protein; Region: OstA_2; pfam13100 694427004855 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 694427004856 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 694427004857 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 694427004858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 694427004859 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 694427004860 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427004861 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 694427004862 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 694427004863 DNA-binding site [nucleotide binding]; DNA binding site 694427004864 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 694427004865 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 694427004866 Walker A/P-loop; other site 694427004867 ATP binding site [chemical binding]; other site 694427004868 Q-loop/lid; other site 694427004869 ABC transporter signature motif; other site 694427004870 Walker B; other site 694427004871 D-loop; other site 694427004872 H-loop/switch region; other site 694427004873 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 694427004874 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 694427004875 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 694427004876 active site 694427004877 HIGH motif; other site 694427004878 KMSKS motif; other site 694427004879 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 694427004880 tRNA binding surface [nucleotide binding]; other site 694427004881 anticodon binding site; other site 694427004882 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 694427004883 dimer interface [polypeptide binding]; other site 694427004884 putative tRNA-binding site [nucleotide binding]; other site 694427004885 Type III secretion needle MxiH like; Region: MxiH; cl09641 694427004886 POT family; Region: PTR2; cl17359 694427004887 FMN-binding domain; Region: FMN_bind; pfam04205 694427004888 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 694427004889 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 694427004890 active site 694427004891 PHP Thumb interface [polypeptide binding]; other site 694427004892 metal binding site [ion binding]; metal-binding site 694427004893 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 694427004894 generic binding surface II; other site 694427004895 generic binding surface I; other site 694427004896 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 694427004897 catalytic residues [active] 694427004898 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 694427004899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427004900 S-adenosylmethionine binding site [chemical binding]; other site 694427004901 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 694427004902 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 694427004903 active site 694427004904 catalytic site [active] 694427004905 substrate binding site [chemical binding]; other site 694427004906 DNA polymerase III subunit beta; Validated; Region: PRK05643 694427004907 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 694427004908 putative DNA binding surface [nucleotide binding]; other site 694427004909 dimer interface [polypeptide binding]; other site 694427004910 beta-clamp/translesion DNA polymerase binding surface; other site 694427004911 beta-clamp/clamp loader binding surface; other site 694427004912 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 694427004913 dimerization interface [polypeptide binding]; other site 694427004914 putative DNA binding site [nucleotide binding]; other site 694427004915 Transcriptional regulators [Transcription]; Region: MarR; COG1846 694427004916 putative Zn2+ binding site [ion binding]; other site 694427004917 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 694427004918 Family description; Region: DsbD_2; pfam13386 694427004919 Predicted permeases [General function prediction only]; Region: COG0701 694427004920 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 694427004921 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 694427004922 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 694427004923 DNA binding residues [nucleotide binding] 694427004924 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 694427004925 dimerization interface [polypeptide binding]; other site 694427004926 putative DNA binding site [nucleotide binding]; other site 694427004927 putative Zn2+ binding site [ion binding]; other site 694427004928 Low molecular weight phosphatase family; Region: LMWPc; cd00115 694427004929 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 694427004930 active site 694427004931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427004932 Coenzyme A binding pocket [chemical binding]; other site 694427004933 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 694427004934 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 694427004935 ATP-grasp domain; Region: ATP-grasp_4; cl17255 694427004936 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 694427004937 arsenical-resistance protein; Region: acr3; TIGR00832 694427004938 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 694427004939 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427004940 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427004941 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 694427004942 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 694427004943 putative active cleft [active] 694427004944 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 694427004945 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 694427004946 catalytic domain interface [polypeptide binding]; other site 694427004947 homodimer interface [polypeptide binding]; other site 694427004948 putative active site [active] 694427004949 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 694427004950 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 694427004951 MFS/sugar transport protein; Region: MFS_2; pfam13347 694427004952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427004953 alpha-galactosidase; Region: PLN02808; cl17638 694427004954 Domain of unknown function (DUF377); Region: DUF377; pfam04041 694427004955 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 694427004956 active site 694427004957 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 694427004958 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 694427004959 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 694427004960 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 694427004961 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 694427004962 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 694427004963 Domain of unknown function (DUF303); Region: DUF303; pfam03629 694427004964 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153 694427004965 homotrimer interaction site [polypeptide binding]; other site 694427004966 putative active site [active] 694427004967 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 694427004968 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 694427004969 starch binding outer membrane protein SusD; Region: SusD; cl17845 694427004970 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 694427004971 SusD family; Region: SusD; pfam07980 694427004972 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427004973 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427004974 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 694427004975 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427004976 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427004977 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 694427004978 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 694427004979 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694427004980 catalytic residue [active] 694427004981 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 694427004982 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 694427004983 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427004984 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 694427004985 putative ABC transporter; Region: ycf24; CHL00085 694427004986 FeS assembly ATPase SufC; Region: sufC; TIGR01978 694427004987 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 694427004988 Walker A/P-loop; other site 694427004989 ATP binding site [chemical binding]; other site 694427004990 Q-loop/lid; other site 694427004991 ABC transporter signature motif; other site 694427004992 Walker B; other site 694427004993 D-loop; other site 694427004994 H-loop/switch region; other site 694427004995 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 694427004996 FeS assembly protein SufD; Region: sufD; TIGR01981 694427004997 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 694427004998 putative active site [active] 694427004999 putative CoA binding site [chemical binding]; other site 694427005000 nudix motif; other site 694427005001 metal binding site [ion binding]; metal-binding site 694427005002 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 694427005003 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 694427005004 RNA binding surface [nucleotide binding]; other site 694427005005 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 694427005006 probable active site [active] 694427005007 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 694427005008 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 694427005009 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 694427005010 active site 694427005011 HIGH motif; other site 694427005012 dimer interface [polypeptide binding]; other site 694427005013 KMSKS motif; other site 694427005014 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 694427005015 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 694427005016 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 694427005017 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 694427005018 active site 694427005019 metal binding site [ion binding]; metal-binding site 694427005020 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 694427005021 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 694427005022 dimer interface [polypeptide binding]; other site 694427005023 active site 694427005024 CoA binding pocket [chemical binding]; other site 694427005025 shikimate kinase; Reviewed; Region: aroK; PRK00131 694427005026 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 694427005027 ADP binding site [chemical binding]; other site 694427005028 magnesium binding site [ion binding]; other site 694427005029 putative shikimate binding site; other site 694427005030 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 694427005031 active site 694427005032 homodimer interface [polypeptide binding]; other site 694427005033 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 694427005034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427005035 S-adenosylmethionine binding site [chemical binding]; other site 694427005036 GtrA-like protein; Region: GtrA; pfam04138 694427005037 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 694427005038 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 694427005039 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 694427005040 Predicted ATPases [General function prediction only]; Region: COG1106 694427005041 RloB-like protein; Region: RloB; pfam13707 694427005042 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 694427005043 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 694427005044 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 694427005045 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 694427005046 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 694427005047 metal binding site [ion binding]; metal-binding site 694427005048 dimer interface [polypeptide binding]; other site 694427005049 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 694427005050 active site 694427005051 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 694427005052 active site 694427005053 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 694427005054 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 694427005055 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 694427005056 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 694427005057 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 694427005058 Domain of unknown function DUF21; Region: DUF21; pfam01595 694427005059 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 694427005060 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 694427005061 Transporter associated domain; Region: CorC_HlyC; smart01091 694427005062 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 694427005063 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694427005064 ATP binding site [chemical binding]; other site 694427005065 putative Mg++ binding site [ion binding]; other site 694427005066 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427005067 nucleotide binding region [chemical binding]; other site 694427005068 ATP-binding site [chemical binding]; other site 694427005069 RQC domain; Region: RQC; pfam09382 694427005070 HRDC domain; Region: HRDC; pfam00570 694427005071 MG2 domain; Region: A2M_N; pfam01835 694427005072 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 694427005073 Domain of unknown function (DUF1735); Region: DUF1735; pfam08522 694427005074 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 694427005075 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427005076 SusD family; Region: SusD; pfam07980 694427005077 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427005078 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427005079 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 694427005080 IPT/TIG domain; Region: TIG; pfam01833 694427005081 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 694427005082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 694427005083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427005084 dimer interface [polypeptide binding]; other site 694427005085 phosphorylation site [posttranslational modification] 694427005086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427005087 ATP binding site [chemical binding]; other site 694427005088 Mg2+ binding site [ion binding]; other site 694427005089 G-X-G motif; other site 694427005090 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 694427005091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427005092 active site 694427005093 phosphorylation site [posttranslational modification] 694427005094 intermolecular recognition site; other site 694427005095 dimerization interface [polypeptide binding]; other site 694427005096 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 694427005097 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427005098 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 694427005099 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 694427005100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427005101 Walker A motif; other site 694427005102 ATP binding site [chemical binding]; other site 694427005103 Walker B motif; other site 694427005104 arginine finger; other site 694427005105 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 694427005106 Clp protease; Region: CLP_protease; pfam00574 694427005107 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 694427005108 oligomer interface [polypeptide binding]; other site 694427005109 active site residues [active] 694427005110 trigger factor; Region: tig; TIGR00115 694427005111 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 694427005112 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 694427005113 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 694427005114 G1 box; other site 694427005115 putative GEF interaction site [polypeptide binding]; other site 694427005116 GTP/Mg2+ binding site [chemical binding]; other site 694427005117 Switch I region; other site 694427005118 G2 box; other site 694427005119 G3 box; other site 694427005120 Switch II region; other site 694427005121 G4 box; other site 694427005122 G5 box; other site 694427005123 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 694427005124 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 694427005125 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 694427005126 Permease; Region: Permease; pfam02405 694427005127 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 694427005128 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 694427005129 Walker A/P-loop; other site 694427005130 ATP binding site [chemical binding]; other site 694427005131 Q-loop/lid; other site 694427005132 ABC transporter signature motif; other site 694427005133 Walker B; other site 694427005134 D-loop; other site 694427005135 H-loop/switch region; other site 694427005136 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 694427005137 putative active site [active] 694427005138 putative catalytic site [active] 694427005139 putative DNA binding site [nucleotide binding]; other site 694427005140 putative phosphate binding site [ion binding]; other site 694427005141 metal binding site A [ion binding]; metal-binding site 694427005142 putative AP binding site [nucleotide binding]; other site 694427005143 putative metal binding site B [ion binding]; other site 694427005144 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 694427005145 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427005146 fumarate hydratase; Provisional; Region: PRK15389 694427005147 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 694427005148 Fumarase C-terminus; Region: Fumerase_C; pfam05683 694427005149 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427005150 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427005151 catalytic residues [active] 694427005152 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 694427005153 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 694427005154 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 694427005155 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 694427005156 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 694427005157 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 694427005158 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 694427005159 active site 694427005160 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 694427005161 HD domain; Region: HD_4; pfam13328 694427005162 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 694427005163 synthetase active site [active] 694427005164 NTP binding site [chemical binding]; other site 694427005165 metal binding site [ion binding]; metal-binding site 694427005166 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 694427005167 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 694427005168 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 694427005169 active site residue [active] 694427005170 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 694427005171 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 694427005172 hexamer interface [polypeptide binding]; other site 694427005173 ligand binding site [chemical binding]; other site 694427005174 putative active site [active] 694427005175 NAD(P) binding site [chemical binding]; other site 694427005176 EamA-like transporter family; Region: EamA; pfam00892 694427005177 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 694427005178 EamA-like transporter family; Region: EamA; pfam00892 694427005179 Sodium Bile acid symporter family; Region: SBF; cl17470 694427005180 KWG Leptospira; Region: KWG; pfam07656 694427005181 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694427005182 primosomal protein N' Region: priA; TIGR00595 694427005183 ATP binding site [chemical binding]; other site 694427005184 putative Mg++ binding site [ion binding]; other site 694427005185 helicase superfamily c-terminal domain; Region: HELICc; smart00490 694427005186 nucleotide binding region [chemical binding]; other site 694427005187 ATP-binding site [chemical binding]; other site 694427005188 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 694427005189 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 694427005190 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 694427005191 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427005192 Walker A/P-loop; other site 694427005193 ATP binding site [chemical binding]; other site 694427005194 Q-loop/lid; other site 694427005195 ABC transporter signature motif; other site 694427005196 Walker B; other site 694427005197 D-loop; other site 694427005198 H-loop/switch region; other site 694427005199 Arginine repressor [Transcription]; Region: ArgR; COG1438 694427005200 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 694427005201 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 694427005202 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 694427005203 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 694427005204 Coenzyme A binding pocket [chemical binding]; other site 694427005205 argininosuccinate synthase; Provisional; Region: PRK13820 694427005206 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 694427005207 Ligand Binding Site [chemical binding]; other site 694427005208 elongation factor P; Validated; Region: PRK00529 694427005209 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 694427005210 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 694427005211 RNA binding site [nucleotide binding]; other site 694427005212 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 694427005213 RNA binding site [nucleotide binding]; other site 694427005214 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 694427005215 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 694427005216 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 694427005217 active site 694427005218 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427005219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427005220 binding surface 694427005221 TPR motif; other site 694427005222 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427005223 Domain of unknown function (DUF3244); Region: DUF3244; pfam11589 694427005224 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427005225 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427005226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 694427005227 TPR motif; other site 694427005228 binding surface 694427005229 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427005230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427005231 binding surface 694427005232 TPR motif; other site 694427005233 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427005234 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427005235 Lyase; Region: Lyase_1; pfam00206 694427005236 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 694427005237 active sites [active] 694427005238 tetramer interface [polypeptide binding]; other site 694427005239 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 694427005240 active site 694427005241 hypothetical protein; Reviewed; Region: PRK12497 694427005242 RmuC family; Region: RmuC; pfam02646 694427005243 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 694427005244 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 694427005245 Zn2+ binding site [ion binding]; other site 694427005246 Mg2+ binding site [ion binding]; other site 694427005247 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 694427005248 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 694427005249 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 694427005250 FMN binding site [chemical binding]; other site 694427005251 active site 694427005252 catalytic residues [active] 694427005253 substrate binding site [chemical binding]; other site 694427005254 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 694427005255 LytTr DNA-binding domain; Region: LytTR; smart00850 694427005256 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 694427005257 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 694427005258 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 694427005259 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 694427005260 intersubunit interface [polypeptide binding]; other site 694427005261 active site 694427005262 zinc binding site [ion binding]; other site 694427005263 Na+ binding site [ion binding]; other site 694427005264 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 694427005265 Putative catalytic NodB homology domain of uncharacterized Mll8295 protein encoded from Rhizobium loti and its bacterial homologs; Region: CE4_Mll8295_like; cd10946 694427005266 NodB motif; other site 694427005267 putative active site [active] 694427005268 putative catalytic site [active] 694427005269 putative Zn binding site [ion binding]; other site 694427005270 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 694427005271 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 694427005272 active site 694427005273 intersubunit interface [polypeptide binding]; other site 694427005274 zinc binding site [ion binding]; other site 694427005275 Na+ binding site [ion binding]; other site 694427005276 Uncharacterized conserved protein [Function unknown]; Region: COG1624 694427005277 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 694427005278 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 694427005279 dihydropteroate synthase; Region: DHPS; TIGR01496 694427005280 substrate binding pocket [chemical binding]; other site 694427005281 dimer interface [polypeptide binding]; other site 694427005282 inhibitor binding site; inhibition site 694427005283 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 694427005284 gliding motility-associated lipoprotein GldJ; Region: GldJ_short; TIGR03530 694427005285 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 694427005286 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 694427005287 putative dimer interface [polypeptide binding]; other site 694427005288 putative anticodon binding site; other site 694427005289 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 694427005290 homodimer interface [polypeptide binding]; other site 694427005291 motif 1; other site 694427005292 motif 2; other site 694427005293 active site 694427005294 motif 3; other site 694427005295 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 694427005296 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 694427005297 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 694427005298 dimer interface [polypeptide binding]; other site 694427005299 PYR/PP interface [polypeptide binding]; other site 694427005300 TPP binding site [chemical binding]; other site 694427005301 substrate binding site [chemical binding]; other site 694427005302 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 694427005303 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 694427005304 TPP-binding site [chemical binding]; other site 694427005305 Transposase IS200 like; Region: Y1_Tnp; pfam01797 694427005306 Autophagy-related protein 27; Region: ATG27; pfam09451 694427005307 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427005308 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427005309 catalytic residues [active] 694427005310 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 694427005311 putative active site [active] 694427005312 dimerization interface [polypeptide binding]; other site 694427005313 putative tRNAtyr binding site [nucleotide binding]; other site 694427005314 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 694427005315 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 694427005316 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 694427005317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427005318 Walker A/P-loop; other site 694427005319 ATP binding site [chemical binding]; other site 694427005320 Q-loop/lid; other site 694427005321 ABC transporter signature motif; other site 694427005322 Walker B; other site 694427005323 D-loop; other site 694427005324 H-loop/switch region; other site 694427005325 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 694427005326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427005327 Walker A motif; other site 694427005328 ATP binding site [chemical binding]; other site 694427005329 Walker B motif; other site 694427005330 arginine finger; other site 694427005331 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 694427005332 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 694427005333 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 694427005334 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 694427005335 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 694427005336 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427005337 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 694427005338 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 694427005339 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 694427005340 putative active site [active] 694427005341 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 694427005342 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427005343 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 694427005344 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 694427005345 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427005346 active site 694427005347 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 694427005348 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 694427005349 active site 694427005350 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694427005351 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 694427005352 putative metal binding site; other site 694427005353 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 694427005354 O-Antigen ligase; Region: Wzy_C; pfam04932 694427005355 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 694427005356 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 694427005357 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 694427005358 active site 694427005359 RNA/DNA hybrid binding site [nucleotide binding]; other site 694427005360 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 694427005361 putative active site [active] 694427005362 putative metal binding site [ion binding]; other site 694427005363 Virulence protein [General function prediction only]; Region: COG3943 694427005364 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 694427005365 T5orf172 domain; Region: T5orf172; pfam10544 694427005366 HsdM N-terminal domain; Region: HsdM_N; pfam12161 694427005367 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 694427005368 Methyltransferase domain; Region: Methyltransf_26; pfam13659 694427005369 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 694427005370 AAA domain; Region: AAA_13; pfam13166 694427005371 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 694427005372 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 694427005373 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 694427005374 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 694427005375 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 694427005376 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694427005377 ATP binding site [chemical binding]; other site 694427005378 putative Mg++ binding site [ion binding]; other site 694427005379 Helix-turn-helix domain; Region: HTH_17; pfam12728 694427005380 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 694427005381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427005382 dimer interface [polypeptide binding]; other site 694427005383 phosphorylation site [posttranslational modification] 694427005384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427005385 ATP binding site [chemical binding]; other site 694427005386 Mg2+ binding site [ion binding]; other site 694427005387 G-X-G motif; other site 694427005388 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 694427005389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427005390 ATP binding site [chemical binding]; other site 694427005391 Mg2+ binding site [ion binding]; other site 694427005392 G-X-G motif; other site 694427005393 Response regulator receiver domain; Region: Response_reg; pfam00072 694427005394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427005395 active site 694427005396 phosphorylation site [posttranslational modification] 694427005397 intermolecular recognition site; other site 694427005398 dimerization interface [polypeptide binding]; other site 694427005399 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 694427005400 trimer interface [polypeptide binding]; other site 694427005401 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 694427005402 Phage Tail Collar Domain; Region: Collar; pfam07484 694427005403 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 694427005404 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 694427005405 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427005406 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 694427005407 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427005408 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 694427005409 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427005410 ligand binding site [chemical binding]; other site 694427005411 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 694427005412 active site 694427005413 Int/Topo IB signature motif; other site 694427005414 DNA binding site [nucleotide binding] 694427005415 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 694427005416 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 694427005417 Walker A/P-loop; other site 694427005418 ATP binding site [chemical binding]; other site 694427005419 Q-loop/lid; other site 694427005420 ABC transporter signature motif; other site 694427005421 Walker B; other site 694427005422 D-loop; other site 694427005423 H-loop/switch region; other site 694427005424 Protein of unknown function DUF45; Region: DUF45; pfam01863 694427005425 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 694427005426 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 694427005427 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 694427005428 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 694427005429 putative FMN binding site [chemical binding]; other site 694427005430 NADPH bind site [chemical binding]; other site 694427005431 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 694427005432 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 694427005433 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 694427005434 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 694427005435 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 694427005436 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694427005437 sequence-specific DNA binding site [nucleotide binding]; other site 694427005438 salt bridge; other site 694427005439 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 694427005440 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 694427005441 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 694427005442 dinuclear metal binding motif [ion binding]; other site 694427005443 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 694427005444 TPR repeat; Region: TPR_11; pfam13414 694427005445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427005446 binding surface 694427005447 TPR motif; other site 694427005448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427005449 binding surface 694427005450 TPR repeat; Region: TPR_11; pfam13414 694427005451 TPR motif; other site 694427005452 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427005453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427005454 binding surface 694427005455 TPR motif; other site 694427005456 TPR repeat; Region: TPR_11; pfam13414 694427005457 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 694427005458 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 694427005459 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 694427005460 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 694427005461 Protein export membrane protein; Region: SecD_SecF; pfam02355 694427005462 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 694427005463 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 694427005464 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 694427005465 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427005466 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 694427005467 HlyD family secretion protein; Region: HlyD_3; pfam13437 694427005468 Outer membrane efflux protein; Region: OEP; pfam02321 694427005469 Outer membrane efflux protein; Region: OEP; pfam02321 694427005470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 694427005471 Putative glucoamylase; Region: Glycoamylase; pfam10091 694427005472 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427005473 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427005474 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 694427005475 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427005476 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427005477 Glycosyl hydrolase family 43; Region: GH43_3; cd08982 694427005478 active site 694427005479 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 694427005480 sugar binding site [chemical binding]; other site 694427005481 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 694427005482 Interdomain contacts; other site 694427005483 Cytokine receptor motif; other site 694427005484 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 694427005485 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 694427005486 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 694427005487 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 694427005488 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 694427005489 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 694427005490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 694427005491 Putative glucoamylase; Region: Glycoamylase; pfam10091 694427005492 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 694427005493 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427005494 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427005495 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 694427005496 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427005497 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427005498 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 694427005499 starch binding outer membrane protein SusD; Region: SusD; cl17845 694427005500 SusD family; Region: SusD; pfam07980 694427005501 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 694427005502 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 694427005503 acyl-activating enzyme (AAE) consensus motif; other site 694427005504 AMP binding site [chemical binding]; other site 694427005505 active site 694427005506 CoA binding site [chemical binding]; other site 694427005507 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 694427005508 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694427005509 non-specific DNA binding site [nucleotide binding]; other site 694427005510 salt bridge; other site 694427005511 sequence-specific DNA binding site [nucleotide binding]; other site 694427005512 Cupin domain; Region: Cupin_2; pfam07883 694427005513 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 694427005514 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 694427005515 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427005516 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 694427005517 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 694427005518 active site 694427005519 Int/Topo IB signature motif; other site 694427005520 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 694427005521 active site 694427005522 Zn binding site [ion binding]; other site 694427005523 Methyltransferase domain; Region: Methyltransf_31; pfam13847 694427005524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427005525 S-adenosylmethionine binding site [chemical binding]; other site 694427005526 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 694427005527 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 694427005528 active site 694427005529 FMN binding site [chemical binding]; other site 694427005530 substrate binding site [chemical binding]; other site 694427005531 homotetramer interface [polypeptide binding]; other site 694427005532 catalytic residue [active] 694427005533 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 694427005534 trimer interface [polypeptide binding]; other site 694427005535 active site 694427005536 TPR repeat; Region: TPR_11; pfam13414 694427005537 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427005538 binding surface 694427005539 TPR motif; other site 694427005540 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427005541 binding surface 694427005542 TPR motif; other site 694427005543 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427005544 binding surface 694427005545 TPR motif; other site 694427005546 TPR repeat; Region: TPR_11; pfam13414 694427005547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427005548 binding surface 694427005549 TPR motif; other site 694427005550 TPR repeat; Region: TPR_11; pfam13414 694427005551 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 694427005552 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 694427005553 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 694427005554 Peptidase family M23; Region: Peptidase_M23; pfam01551 694427005555 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 694427005556 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 694427005557 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 694427005558 ATP binding site [chemical binding]; other site 694427005559 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 694427005560 active site 694427005561 putative metal-binding site [ion binding]; other site 694427005562 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 694427005563 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 694427005564 nucleoside/Zn binding site; other site 694427005565 dimer interface [polypeptide binding]; other site 694427005566 catalytic motif [active] 694427005567 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 694427005568 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 694427005569 putative active site [active] 694427005570 putative metal binding site [ion binding]; other site 694427005571 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 694427005572 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 694427005573 active site 694427005574 nucleophile elbow; other site 694427005575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 694427005576 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 694427005577 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 694427005578 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 694427005579 putative active site [active] 694427005580 putative metal binding site [ion binding]; other site 694427005581 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 694427005582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427005583 S-adenosylmethionine binding site [chemical binding]; other site 694427005584 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 694427005585 primary dimer interface [polypeptide binding]; other site 694427005586 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 694427005587 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 694427005588 Zn binding sites [ion binding]; other site 694427005589 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 694427005590 catalytic motif [active] 694427005591 Catalytic residue [active] 694427005592 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 694427005593 active site 694427005594 Peptidase family M48; Region: Peptidase_M48; pfam01435 694427005595 DNA protecting protein DprA; Region: dprA; TIGR00732 694427005596 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 694427005597 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 694427005598 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 694427005599 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 694427005600 purine monophosphate binding site [chemical binding]; other site 694427005601 dimer interface [polypeptide binding]; other site 694427005602 putative catalytic residues [active] 694427005603 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 694427005604 rod shape-determining protein MreB; Provisional; Region: PRK13927 694427005605 MreB and similar proteins; Region: MreB_like; cd10225 694427005606 nucleotide binding site [chemical binding]; other site 694427005607 Mg binding site [ion binding]; other site 694427005608 putative protofilament interaction site [polypeptide binding]; other site 694427005609 RodZ interaction site [polypeptide binding]; other site 694427005610 rod shape-determining protein MreC; Provisional; Region: PRK13922 694427005611 rod shape-determining protein MreC; Region: MreC; pfam04085 694427005612 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 694427005613 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 694427005614 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 694427005615 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 694427005616 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 694427005617 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 694427005618 propionate/acetate kinase; Provisional; Region: PRK12379 694427005619 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 694427005620 propionate/acetate kinase; Provisional; Region: PRK12379 694427005621 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 694427005622 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 694427005623 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 694427005624 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 694427005625 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 694427005626 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 694427005627 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 694427005628 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 694427005629 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 694427005630 substrate binding pocket [chemical binding]; other site 694427005631 chain length determination region; other site 694427005632 substrate-Mg2+ binding site; other site 694427005633 catalytic residues [active] 694427005634 aspartate-rich region 1; other site 694427005635 active site lid residues [active] 694427005636 aspartate-rich region 2; other site 694427005637 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 694427005638 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 694427005639 ATP-grasp domain; Region: ATP-grasp_4; cl17255 694427005640 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 694427005641 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 694427005642 RNA binding surface [nucleotide binding]; other site 694427005643 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 694427005644 active site 694427005645 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 694427005646 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 694427005647 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 694427005648 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427005649 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 694427005650 catalytic motif [active] 694427005651 Catalytic residue [active] 694427005652 Aspartyl protease; Region: Asp_protease_2; pfam13650 694427005653 inhibitor binding site; inhibition site 694427005654 catalytic motif [active] 694427005655 Catalytic residue [active] 694427005656 Active site flap [active] 694427005657 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 694427005658 protein binding site [polypeptide binding]; other site 694427005659 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 694427005660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427005661 NAD(P) binding site [chemical binding]; other site 694427005662 active site 694427005663 short chain dehydrogenase; Validated; Region: PRK06182 694427005664 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 694427005665 NADP binding site [chemical binding]; other site 694427005666 active site 694427005667 steroid binding site; other site 694427005668 quinolinate synthetase; Provisional; Region: PRK09375 694427005669 Helix-turn-helix domain; Region: HTH_18; pfam12833 694427005670 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 694427005671 Peptidase family U32; Region: Peptidase_U32; pfam01136 694427005672 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 694427005673 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 694427005674 FMN binding site [chemical binding]; other site 694427005675 active site 694427005676 catalytic residues [active] 694427005677 substrate binding site [chemical binding]; other site 694427005678 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 694427005679 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 694427005680 active site 694427005681 Zn binding site [ion binding]; other site 694427005682 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 694427005683 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 694427005684 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 694427005685 GIY-YIG motif/motif A; other site 694427005686 active site 694427005687 catalytic site [active] 694427005688 putative DNA binding site [nucleotide binding]; other site 694427005689 metal binding site [ion binding]; metal-binding site 694427005690 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 694427005691 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 694427005692 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 694427005693 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 694427005694 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 694427005695 Uncharacterized conserved protein [Function unknown]; Region: COG3410 694427005696 four helix bundle suffix domain; Region: 4helix_suffix; TIGR04258 694427005697 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 694427005698 Hemerythrin-like domain; Region: Hr-like; cd12108 694427005699 Fe binding site [ion binding]; other site 694427005700 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 694427005701 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 694427005702 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 694427005703 Bacterial Ig-like domain; Region: Big_5; pfam13205 694427005704 Bacterial Ig-like domain; Region: Big_5; pfam13205 694427005705 Bacterial Ig-like domain; Region: Big_5; pfam13205 694427005706 Bacterial Ig-like domain; Region: Big_5; pfam13205 694427005707 Bacterial Ig-like domain; Region: Big_5; pfam13205 694427005708 Bacterial Ig-like domain; Region: Big_5; pfam13205 694427005709 Bacterial Ig-like domain; Region: Big_5; pfam13205 694427005710 Bacterial Ig-like domain; Region: Big_5; pfam13205 694427005711 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 694427005712 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 694427005713 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 694427005714 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 694427005715 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 694427005716 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 694427005717 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 694427005718 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 694427005719 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 694427005720 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 694427005721 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 694427005722 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 694427005723 putative DNA binding site [nucleotide binding]; other site 694427005724 putative Zn2+ binding site [ion binding]; other site 694427005725 AsnC family; Region: AsnC_trans_reg; pfam01037 694427005726 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 694427005727 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 694427005728 active site 694427005729 HIGH motif; other site 694427005730 dimer interface [polypeptide binding]; other site 694427005731 KMSKS motif; other site 694427005732 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 694427005733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694427005734 motif II; other site 694427005735 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694427005736 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 694427005737 Putative esterase; Region: Esterase; pfam00756 694427005738 S-formylglutathione hydrolase; Region: PLN02442 694427005739 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 694427005740 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 694427005741 active site 694427005742 substrate-binding site [chemical binding]; other site 694427005743 metal-binding site [ion binding] 694427005744 ATP binding site [chemical binding]; other site 694427005745 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 694427005746 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427005747 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 694427005748 DNA binding residues [nucleotide binding] 694427005749 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 694427005750 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 694427005751 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 694427005752 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 694427005753 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 694427005754 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 694427005755 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 694427005756 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 694427005757 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 694427005758 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 694427005759 active site 694427005760 catalytic site [active] 694427005761 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 694427005762 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 694427005763 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 694427005764 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 694427005765 Two component regulator propeller; Region: Reg_prop; pfam07494 694427005766 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 694427005767 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 694427005768 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427005769 dimer interface [polypeptide binding]; other site 694427005770 phosphorylation site [posttranslational modification] 694427005771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427005772 ATP binding site [chemical binding]; other site 694427005773 Mg2+ binding site [ion binding]; other site 694427005774 G-X-G motif; other site 694427005775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427005776 Response regulator receiver domain; Region: Response_reg; pfam00072 694427005777 active site 694427005778 phosphorylation site [posttranslational modification] 694427005779 intermolecular recognition site; other site 694427005780 dimerization interface [polypeptide binding]; other site 694427005781 Helix-turn-helix domain; Region: HTH_18; pfam12833 694427005782 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427005783 Two component regulator propeller; Region: Reg_prop; pfam07494 694427005784 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 694427005785 PA14 domain; Region: PA14; cl08459 694427005786 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 694427005787 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 694427005788 putative active site [active] 694427005789 putative catalytic site [active] 694427005790 H+ Antiporter protein; Region: 2A0121; TIGR00900 694427005791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427005792 putative substrate translocation pore; other site 694427005793 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 694427005794 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 694427005795 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 694427005796 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 694427005797 Phage Tail Collar Domain; Region: Collar; pfam07484 694427005798 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 694427005799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427005800 FeS/SAM binding site; other site 694427005801 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 694427005802 Helix-turn-helix domain; Region: HTH_18; pfam12833 694427005803 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427005804 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 694427005805 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 694427005806 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 694427005807 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 694427005808 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 694427005809 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 694427005810 active site 694427005811 catalytic residues [active] 694427005812 galactokinase; Provisional; Region: PRK05322 694427005813 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 694427005814 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 694427005815 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 694427005816 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 694427005817 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427005818 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427005819 DNA binding residues [nucleotide binding] 694427005820 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 694427005821 Uncharacterized conserved protein [Function unknown]; Region: COG2966 694427005822 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 694427005823 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 694427005824 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 694427005825 metal-binding site [ion binding] 694427005826 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 694427005827 Soluble P-type ATPase [General function prediction only]; Region: COG4087 694427005828 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 694427005829 metal-binding site [ion binding] 694427005830 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 694427005831 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 694427005832 active site 694427005833 Zn binding site [ion binding]; other site 694427005834 Trehalose utilisation; Region: ThuA; pfam06283 694427005835 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 694427005836 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 694427005837 tandem repeat interface [polypeptide binding]; other site 694427005838 oligomer interface [polypeptide binding]; other site 694427005839 active site residues [active] 694427005840 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 694427005841 tandem repeat interface [polypeptide binding]; other site 694427005842 oligomer interface [polypeptide binding]; other site 694427005843 active site residues [active] 694427005844 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 694427005845 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 694427005846 putative dimer interface [polypeptide binding]; other site 694427005847 M6 family metalloprotease domain; Region: M6dom_TIGR03296 694427005848 Protein of unknown function (DUF2582); Region: DUF2582; pfam10771 694427005849 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 694427005850 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 694427005851 acyl-activating enzyme (AAE) consensus motif; other site 694427005852 putative AMP binding site [chemical binding]; other site 694427005853 putative active site [active] 694427005854 putative CoA binding site [chemical binding]; other site 694427005855 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 694427005856 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 694427005857 dimerization interface [polypeptide binding]; other site 694427005858 active site 694427005859 metal binding site [ion binding]; metal-binding site 694427005860 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 694427005861 dsRNA binding site [nucleotide binding]; other site 694427005862 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 694427005863 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 694427005864 dimer interface [polypeptide binding]; other site 694427005865 active site 694427005866 acyl carrier protein; Provisional; Region: acpP; PRK00982 694427005867 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 694427005868 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 694427005869 active site 694427005870 substrate binding site [chemical binding]; other site 694427005871 cosubstrate binding site; other site 694427005872 catalytic site [active] 694427005873 GTP-binding protein YchF; Reviewed; Region: PRK09601 694427005874 YchF GTPase; Region: YchF; cd01900 694427005875 G1 box; other site 694427005876 GTP/Mg2+ binding site [chemical binding]; other site 694427005877 Switch I region; other site 694427005878 G2 box; other site 694427005879 Switch II region; other site 694427005880 G3 box; other site 694427005881 G4 box; other site 694427005882 G5 box; other site 694427005883 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 694427005884 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 694427005885 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 694427005886 FecR protein; Region: FecR; pfam04773 694427005887 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 694427005888 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427005889 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427005890 DNA binding residues [nucleotide binding] 694427005891 Response regulator receiver domain; Region: Response_reg; pfam00072 694427005892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427005893 active site 694427005894 phosphorylation site [posttranslational modification] 694427005895 intermolecular recognition site; other site 694427005896 dimerization interface [polypeptide binding]; other site 694427005897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427005898 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 694427005899 Walker A motif; other site 694427005900 ATP binding site [chemical binding]; other site 694427005901 Walker B motif; other site 694427005902 arginine finger; other site 694427005903 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 694427005904 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 694427005905 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 694427005906 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 694427005907 PAS fold; Region: PAS_4; pfam08448 694427005908 PAS domain S-box; Region: sensory_box; TIGR00229 694427005909 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005910 putative active site [active] 694427005911 heme pocket [chemical binding]; other site 694427005912 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 694427005913 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 694427005914 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005915 putative active site [active] 694427005916 heme pocket [chemical binding]; other site 694427005917 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005918 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 694427005919 putative active site [active] 694427005920 heme pocket [chemical binding]; other site 694427005921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005922 putative active site [active] 694427005923 heme pocket [chemical binding]; other site 694427005924 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 694427005925 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005926 putative active site [active] 694427005927 heme pocket [chemical binding]; other site 694427005928 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427005929 dimer interface [polypeptide binding]; other site 694427005930 phosphorylation site [posttranslational modification] 694427005931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427005932 ATP binding site [chemical binding]; other site 694427005933 Mg2+ binding site [ion binding]; other site 694427005934 G-X-G motif; other site 694427005935 Response regulator receiver domain; Region: Response_reg; pfam00072 694427005936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427005937 active site 694427005938 phosphorylation site [posttranslational modification] 694427005939 intermolecular recognition site; other site 694427005940 dimerization interface [polypeptide binding]; other site 694427005941 Response regulator receiver domain; Region: Response_reg; pfam00072 694427005942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427005943 active site 694427005944 phosphorylation site [posttranslational modification] 694427005945 intermolecular recognition site; other site 694427005946 dimerization interface [polypeptide binding]; other site 694427005947 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005948 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 694427005949 putative active site [active] 694427005950 heme pocket [chemical binding]; other site 694427005951 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005952 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 694427005953 putative active site [active] 694427005954 heme pocket [chemical binding]; other site 694427005955 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005956 putative active site [active] 694427005957 heme pocket [chemical binding]; other site 694427005958 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005959 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 694427005960 putative active site [active] 694427005961 heme pocket [chemical binding]; other site 694427005962 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005963 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 694427005964 putative active site [active] 694427005965 heme pocket [chemical binding]; other site 694427005966 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005967 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 694427005968 putative active site [active] 694427005969 heme pocket [chemical binding]; other site 694427005970 PAS domain S-box; Region: sensory_box; TIGR00229 694427005971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005972 putative active site [active] 694427005973 heme pocket [chemical binding]; other site 694427005974 PAS domain S-box; Region: sensory_box; TIGR00229 694427005975 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005976 putative active site [active] 694427005977 heme pocket [chemical binding]; other site 694427005978 PAS domain S-box; Region: sensory_box; TIGR00229 694427005979 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427005980 putative active site [active] 694427005981 heme pocket [chemical binding]; other site 694427005982 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 694427005983 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 694427005984 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 694427005985 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 694427005986 dimerization interface [polypeptide binding]; other site 694427005987 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427005988 dimer interface [polypeptide binding]; other site 694427005989 phosphorylation site [posttranslational modification] 694427005990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427005991 ATP binding site [chemical binding]; other site 694427005992 Mg2+ binding site [ion binding]; other site 694427005993 G-X-G motif; other site 694427005994 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 694427005995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427005996 active site 694427005997 phosphorylation site [posttranslational modification] 694427005998 intermolecular recognition site; other site 694427005999 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 694427006000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427006001 active site 694427006002 phosphorylation site [posttranslational modification] 694427006003 intermolecular recognition site; other site 694427006004 dimerization interface [polypeptide binding]; other site 694427006005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427006006 active site 694427006007 phosphorylation site [posttranslational modification] 694427006008 intermolecular recognition site; other site 694427006009 dimerization interface [polypeptide binding]; other site 694427006010 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427006011 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 694427006012 putative active site [active] 694427006013 heme pocket [chemical binding]; other site 694427006014 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427006015 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 694427006016 putative active site [active] 694427006017 heme pocket [chemical binding]; other site 694427006018 GAF domain; Region: GAF_2; pfam13185 694427006019 GAF domain; Region: GAF; pfam01590 694427006020 PAS domain; Region: PAS; smart00091 694427006021 PAS domain S-box; Region: sensory_box; TIGR00229 694427006022 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 694427006023 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 694427006024 Histidine kinase; Region: HisKA_3; pfam07730 694427006025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427006026 ATP binding site [chemical binding]; other site 694427006027 Mg2+ binding site [ion binding]; other site 694427006028 G-X-G motif; other site 694427006029 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 694427006030 Sensory domain found in PocR; Region: PocR; pfam10114 694427006031 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427006032 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 694427006033 putative active site [active] 694427006034 heme pocket [chemical binding]; other site 694427006035 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 694427006036 PAS domain S-box; Region: sensory_box; TIGR00229 694427006037 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427006038 putative active site [active] 694427006039 heme pocket [chemical binding]; other site 694427006040 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 694427006041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427006042 ATP binding site [chemical binding]; other site 694427006043 Mg2+ binding site [ion binding]; other site 694427006044 G-X-G motif; other site 694427006045 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 694427006046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427006047 active site 694427006048 phosphorylation site [posttranslational modification] 694427006049 intermolecular recognition site; other site 694427006050 dimerization interface [polypeptide binding]; other site 694427006051 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 694427006052 DNA binding residues [nucleotide binding] 694427006053 dimerization interface [polypeptide binding]; other site 694427006054 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 694427006055 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 694427006056 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 694427006057 active site 694427006058 acetylornithine aminotransferase; Provisional; Region: PRK02627 694427006059 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 694427006060 inhibitor-cofactor binding pocket; inhibition site 694427006061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427006062 catalytic residue [active] 694427006063 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 694427006064 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 694427006065 putative NADP binding site [chemical binding]; other site 694427006066 putative substrate binding site [chemical binding]; other site 694427006067 active site 694427006068 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 694427006069 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 694427006070 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 694427006071 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 694427006072 active site 694427006073 ribonuclease P; Reviewed; Region: rnpA; PRK01903 694427006074 Haemolytic domain; Region: Haemolytic; pfam01809 694427006075 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 694427006076 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 694427006077 purine nucleoside phosphorylase; Provisional; Region: PRK08202 694427006078 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 694427006079 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 694427006080 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 694427006081 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 694427006082 Walker A/P-loop; other site 694427006083 ATP binding site [chemical binding]; other site 694427006084 Q-loop/lid; other site 694427006085 ABC transporter signature motif; other site 694427006086 Walker B; other site 694427006087 D-loop; other site 694427006088 H-loop/switch region; other site 694427006089 adenylosuccinate lyase; Provisional; Region: PRK09285 694427006090 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 694427006091 tetramer interface [polypeptide binding]; other site 694427006092 active site 694427006093 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 694427006094 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 694427006095 homodimer interface [polypeptide binding]; other site 694427006096 metal binding site [ion binding]; metal-binding site 694427006097 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 694427006098 intersubunit interface [polypeptide binding]; other site 694427006099 active site 694427006100 catalytic residue [active] 694427006101 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 694427006102 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 694427006103 substrate binding pocket [chemical binding]; other site 694427006104 chain length determination region; other site 694427006105 substrate-Mg2+ binding site; other site 694427006106 catalytic residues [active] 694427006107 aspartate-rich region 1; other site 694427006108 active site lid residues [active] 694427006109 aspartate-rich region 2; other site 694427006110 DNA polymerase I; Provisional; Region: PRK05755 694427006111 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 694427006112 active site 694427006113 metal binding site 1 [ion binding]; metal-binding site 694427006114 putative 5' ssDNA interaction site; other site 694427006115 metal binding site 3; metal-binding site 694427006116 metal binding site 2 [ion binding]; metal-binding site 694427006117 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 694427006118 putative DNA binding site [nucleotide binding]; other site 694427006119 putative metal binding site [ion binding]; other site 694427006120 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 694427006121 active site 694427006122 catalytic site [active] 694427006123 substrate binding site [chemical binding]; other site 694427006124 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 694427006125 active site 694427006126 DNA binding site [nucleotide binding] 694427006127 catalytic site [active] 694427006128 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 694427006129 Penicillinase repressor; Region: Pencillinase_R; pfam03965 694427006130 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 694427006131 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 694427006132 Recombination protein O N terminal; Region: RecO_N; pfam11967 694427006133 Recombination protein O C terminal; Region: RecO_C; pfam02565 694427006134 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 694427006135 NlpC/P60 family; Region: NLPC_P60; pfam00877 694427006136 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 694427006137 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 694427006138 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 694427006139 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 694427006140 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 694427006141 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 694427006142 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 694427006143 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 694427006144 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 694427006145 dimer interface [polypeptide binding]; other site 694427006146 catalytic triad [active] 694427006147 four helix bundle protein; Region: TIGR02436 694427006148 hypothetical protein; Reviewed; Region: PRK00024 694427006149 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 694427006150 MPN+ (JAMM) motif; other site 694427006151 Zinc-binding site [ion binding]; other site 694427006152 Superfamily II helicase [General function prediction only]; Region: COG1204 694427006153 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694427006154 ATP binding site [chemical binding]; other site 694427006155 putative Mg++ binding site [ion binding]; other site 694427006156 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 694427006157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427006158 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 694427006159 Coenzyme A binding pocket [chemical binding]; other site 694427006160 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427006161 Coenzyme A binding pocket [chemical binding]; other site 694427006162 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 694427006163 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 694427006164 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 694427006165 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 694427006166 trimer interface [polypeptide binding]; other site 694427006167 active site 694427006168 G bulge; other site 694427006169 thiamine-monophosphate kinase; Region: thiL; TIGR01379 694427006170 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 694427006171 ATP binding site [chemical binding]; other site 694427006172 dimerization interface [polypeptide binding]; other site 694427006173 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 694427006174 potential frameshift: common BLAST hit: gi|213693059|ref|YP_002323645.1| protein of unknown function DUF404 694427006175 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 694427006176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 694427006177 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 694427006178 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 694427006179 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 694427006180 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 694427006181 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 694427006182 active site 694427006183 Zn binding site [ion binding]; other site 694427006184 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_3; cd06253 694427006185 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 694427006186 putative active site [active] 694427006187 Zn binding site [ion binding]; other site 694427006188 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 694427006189 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 694427006190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427006191 S-adenosylmethionine binding site [chemical binding]; other site 694427006192 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427006193 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 694427006194 Predicted acetyltransferase [General function prediction only]; Region: COG5628 694427006195 Coenzyme A binding pocket [chemical binding]; other site 694427006196 Predicted periplasmic protein (DUF2271); Region: DUF2271; cl17856 694427006197 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 694427006198 peptide chain release factor 2; Validated; Region: prfB; PRK00578 694427006199 PCRF domain; Region: PCRF; pfam03462 694427006200 RF-1 domain; Region: RF-1; pfam00472 694427006201 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 694427006202 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 694427006203 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 694427006204 DNA primase, catalytic core; Region: dnaG; TIGR01391 694427006205 CHC2 zinc finger; Region: zf-CHC2; cl17510 694427006206 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 694427006207 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 694427006208 active site 694427006209 metal binding site [ion binding]; metal-binding site 694427006210 interdomain interaction site; other site 694427006211 Radical SAM superfamily; Region: Radical_SAM; pfam04055 694427006212 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427006213 FeS/SAM binding site; other site 694427006214 conserved hypothetical protein; Region: MJ1255; TIGR00661 694427006215 4Fe-4S binding domain; Region: Fer4; cl02805 694427006216 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 694427006217 4Fe-4S binding domain; Region: Fer4; pfam00037 694427006218 Nitroreductase family; Region: Nitroreductase; pfam00881 694427006219 Colicin V production protein; Region: Colicin_V; pfam02674 694427006220 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 694427006221 RNA/DNA hybrid binding site [nucleotide binding]; other site 694427006222 active site 694427006223 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 694427006224 Surface antigen; Region: Bac_surface_Ag; pfam01103 694427006225 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 694427006226 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 694427006227 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427006228 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 694427006229 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427006230 pyruvate kinase; Provisional; Region: PRK05826 694427006231 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 694427006232 domain interfaces; other site 694427006233 active site 694427006234 Dehydroquinase class II; Region: DHquinase_II; pfam01220 694427006235 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 694427006236 trimer interface [polypeptide binding]; other site 694427006237 active site 694427006238 dimer interface [polypeptide binding]; other site 694427006239 Uncharacterized conserved protein [Function unknown]; Region: COG4095 694427006240 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 694427006241 putative catalytic site [active] 694427006242 putative metal binding site [ion binding]; other site 694427006243 putative phosphate binding site [ion binding]; other site 694427006244 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 694427006245 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 694427006246 ligand binding site [chemical binding]; other site 694427006247 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 694427006248 Protein of unknown function DUF58; Region: DUF58; pfam01882 694427006249 MoxR-like ATPases [General function prediction only]; Region: COG0714 694427006250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427006251 Walker A motif; other site 694427006252 ATP binding site [chemical binding]; other site 694427006253 Walker B motif; other site 694427006254 arginine finger; other site 694427006255 Putative sensor; Region: Sensor; pfam13796 694427006256 Integral membrane protein DUF95; Region: DUF95; pfam01944 694427006257 Predicted membrane protein/domain [Function unknown]; Region: COG1714 694427006258 ribonuclease R; Region: RNase_R; TIGR02063 694427006259 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 694427006260 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 694427006261 active site 694427006262 catalytic tetrad [active] 694427006263 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 694427006264 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 694427006265 active site 694427006266 catalytic tetrad [active] 694427006267 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 694427006268 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 694427006269 active site 694427006270 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 694427006271 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 694427006272 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 694427006273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427006274 putative substrate translocation pore; other site 694427006275 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 694427006276 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427006277 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 694427006278 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 694427006279 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 694427006280 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 694427006281 oligomer interface [polypeptide binding]; other site 694427006282 metal binding site [ion binding]; metal-binding site 694427006283 metal binding site [ion binding]; metal-binding site 694427006284 Cl binding site [ion binding]; other site 694427006285 aspartate ring; other site 694427006286 basic sphincter; other site 694427006287 putative hydrophobic gate; other site 694427006288 periplasmic entrance; other site 694427006289 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 694427006290 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 694427006291 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 694427006292 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 694427006293 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 694427006294 putative active site [active] 694427006295 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 694427006296 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694427006297 motif II; other site 694427006298 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 694427006299 tellurium resistance terB-like protein; Region: terB_like; cd07177 694427006300 metal binding site [ion binding]; metal-binding site 694427006301 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 694427006302 HSP70 interaction site [polypeptide binding]; other site 694427006303 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 694427006304 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427006305 active site 694427006306 HIGH motif; other site 694427006307 nucleotide binding site [chemical binding]; other site 694427006308 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 694427006309 KMSKS motif; other site 694427006310 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 694427006311 tRNA binding surface [nucleotide binding]; other site 694427006312 anticodon binding site; other site 694427006313 Archaeal ATPase; Region: Arch_ATPase; pfam01637 694427006314 Ribosome-binding factor A; Region: RBFA; pfam02033 694427006315 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 694427006316 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694427006317 FtsX-like permease family; Region: FtsX; pfam02687 694427006318 Transcriptional regulators [Transcription]; Region: PurR; COG1609 694427006319 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 694427006320 DNA binding site [nucleotide binding] 694427006321 domain linker motif; other site 694427006322 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 694427006323 ligand binding site [chemical binding]; other site 694427006324 dimerization interface [polypeptide binding]; other site 694427006325 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 694427006326 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 694427006327 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 694427006328 putative NAD(P) binding site [chemical binding]; other site 694427006329 catalytic Zn binding site [ion binding]; other site 694427006330 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 694427006331 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 694427006332 active site 694427006333 catalytic tetrad [active] 694427006334 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 694427006335 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 694427006336 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 694427006337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427006338 putative substrate translocation pore; other site 694427006339 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 694427006340 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 694427006341 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 694427006342 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 694427006343 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 694427006344 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 694427006345 GIY-YIG motif/motif A; other site 694427006346 putative active site [active] 694427006347 putative metal binding site [ion binding]; other site 694427006348 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427006349 von Willebrand factor; Region: vWF_A; pfam12450 694427006350 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 694427006351 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 694427006352 metal ion-dependent adhesion site (MIDAS); other site 694427006353 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 694427006354 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 694427006355 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427006356 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427006357 DNA binding residues [nucleotide binding] 694427006358 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427006359 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 694427006360 Interdomain contacts; other site 694427006361 Cytokine receptor motif; other site 694427006362 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 694427006363 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427006364 AAA domain; Region: AAA_21; pfam13304 694427006365 Walker A/P-loop; other site 694427006366 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 694427006367 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 694427006368 putative active site [active] 694427006369 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 694427006370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427006371 Coenzyme A binding pocket [chemical binding]; other site 694427006372 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 694427006373 Active site serine [active] 694427006374 Domain of unknown function (DUF303); Region: DUF303; pfam03629 694427006375 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 694427006376 Domain of unknown function (DUF303); Region: DUF303; pfam03629 694427006377 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 694427006378 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 694427006379 putative active site [active] 694427006380 putative metal binding site [ion binding]; other site 694427006381 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 694427006382 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 694427006383 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 694427006384 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694427006385 non-specific DNA binding site [nucleotide binding]; other site 694427006386 salt bridge; other site 694427006387 sequence-specific DNA binding site [nucleotide binding]; other site 694427006388 Tic20-like protein; Region: Tic20; pfam09685 694427006389 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 694427006390 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427006391 catalytic residues [active] 694427006392 transaldolase-like protein; Provisional; Region: PTZ00411 694427006393 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 694427006394 active site 694427006395 dimer interface [polypeptide binding]; other site 694427006396 catalytic residue [active] 694427006397 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 694427006398 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 694427006399 SLBB domain; Region: SLBB; pfam10531 694427006400 Chain length determinant protein; Region: Wzz; cl15801 694427006401 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 694427006402 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 694427006403 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 694427006404 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 694427006405 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 694427006406 GDP-Fucose binding site [chemical binding]; other site 694427006407 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 694427006408 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 694427006409 trimer interface [polypeptide binding]; other site 694427006410 active site 694427006411 substrate binding site [chemical binding]; other site 694427006412 CoA binding site [chemical binding]; other site 694427006413 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 694427006414 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427006415 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 694427006416 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 694427006417 trimer interface [polypeptide binding]; other site 694427006418 active site 694427006419 substrate binding site [chemical binding]; other site 694427006420 CoA binding site [chemical binding]; other site 694427006421 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 694427006422 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427006423 active site 694427006424 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427006425 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 694427006426 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427006427 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 694427006428 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427006429 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 694427006430 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 694427006431 active site 694427006432 ATP binding site [chemical binding]; other site 694427006433 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 694427006434 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427006435 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 694427006436 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 694427006437 putative active site [active] 694427006438 putative metal binding site [ion binding]; other site 694427006439 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 694427006440 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427006441 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427006442 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 694427006443 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 694427006444 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 694427006445 Bacterial sugar transferase; Region: Bac_transf; pfam02397 694427006446 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427006447 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427006448 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 694427006449 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427006450 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427006451 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427006452 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 694427006453 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427006454 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 694427006455 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427006456 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 694427006457 adenylate kinase; Reviewed; Region: adk; PRK00279 694427006458 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 694427006459 AMP-binding site [chemical binding]; other site 694427006460 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 694427006461 GTPase CgtA; Reviewed; Region: obgE; PRK12299 694427006462 GTP1/OBG; Region: GTP1_OBG; pfam01018 694427006463 Obg GTPase; Region: Obg; cd01898 694427006464 G1 box; other site 694427006465 GTP/Mg2+ binding site [chemical binding]; other site 694427006466 Switch I region; other site 694427006467 G2 box; other site 694427006468 G3 box; other site 694427006469 Switch II region; other site 694427006470 G4 box; other site 694427006471 G5 box; other site 694427006472 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 694427006473 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 694427006474 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 694427006475 B3/4 domain; Region: B3_4; pfam03483 694427006476 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 694427006477 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 694427006478 Cl- selectivity filter; other site 694427006479 Cl- binding residues [ion binding]; other site 694427006480 pore gating glutamate residue; other site 694427006481 dimer interface [polypeptide binding]; other site 694427006482 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 694427006483 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 694427006484 Bacterial sugar transferase; Region: Bac_transf; pfam02397 694427006485 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 694427006486 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 694427006487 DHH family; Region: DHH; pfam01368 694427006488 DHHA1 domain; Region: DHHA1; pfam02272 694427006489 Domain of unknown function DUF20; Region: UPF0118; pfam01594 694427006490 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 694427006491 thymidine kinase; Provisional; Region: PRK04296 694427006492 Predicted methyltransferases [General function prediction only]; Region: COG0313 694427006493 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 694427006494 putative SAM binding site [chemical binding]; other site 694427006495 putative homodimer interface [polypeptide binding]; other site 694427006496 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 694427006497 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 694427006498 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694427006499 motif II; other site 694427006500 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 694427006501 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 694427006502 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 694427006503 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 694427006504 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 694427006505 putative rRNA binding site [nucleotide binding]; other site 694427006506 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 694427006507 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 694427006508 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 694427006509 active site triad [active] 694427006510 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 694427006511 active site 694427006512 dimerization interface [polypeptide binding]; other site 694427006513 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 694427006514 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 694427006515 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 694427006516 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 694427006517 catalytic motif [active] 694427006518 Catalytic residue [active] 694427006519 Kelch motif; Region: Kelch_1; pfam01344 694427006520 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 694427006521 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427006522 binding surface 694427006523 TPR repeat; Region: TPR_11; pfam13414 694427006524 TPR motif; other site 694427006525 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427006526 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 694427006527 RibD C-terminal domain; Region: RibD_C; cl17279 694427006528 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 694427006529 Predicted integral membrane protein [Function unknown]; Region: COG5542 694427006530 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 694427006531 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 694427006532 homodecamer interface [polypeptide binding]; other site 694427006533 GTP cyclohydrolase I; Provisional; Region: PLN03044 694427006534 active site 694427006535 putative catalytic site residues [active] 694427006536 zinc binding site [ion binding]; other site 694427006537 GTP-CH-I/GFRP interaction surface; other site 694427006538 Sporulation related domain; Region: SPOR; pfam05036 694427006539 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 694427006540 substrate binding site; other site 694427006541 dimer interface; other site 694427006542 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 694427006543 Acyltransferase family; Region: Acyl_transf_3; pfam01757 694427006544 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 694427006545 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 694427006546 generic binding surface II; other site 694427006547 ssDNA binding site; other site 694427006548 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694427006549 ATP binding site [chemical binding]; other site 694427006550 putative Mg++ binding site [ion binding]; other site 694427006551 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427006552 nucleotide binding region [chemical binding]; other site 694427006553 ATP-binding site [chemical binding]; other site 694427006554 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 694427006555 active site 694427006556 multimer interface [polypeptide binding]; other site 694427006557 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 694427006558 Peptidase family M23; Region: Peptidase_M23; pfam01551 694427006559 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 694427006560 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 694427006561 Adenosylhomocysteinase; Provisional; Region: PTZ00075 694427006562 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 694427006563 homotetramer interface [polypeptide binding]; other site 694427006564 ligand binding site [chemical binding]; other site 694427006565 catalytic site [active] 694427006566 NAD binding site [chemical binding]; other site 694427006567 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 694427006568 active site 694427006569 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 694427006570 C-terminal peptidase (prc); Region: prc; TIGR00225 694427006571 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 694427006572 protein binding site [polypeptide binding]; other site 694427006573 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 694427006574 Catalytic dyad [active] 694427006575 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 694427006576 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 694427006577 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 694427006578 active site 694427006579 AAA domain; Region: AAA_28; pfam13521 694427006580 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 694427006581 serine O-acetyltransferase; Region: cysE; TIGR01172 694427006582 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 694427006583 trimer interface [polypeptide binding]; other site 694427006584 active site 694427006585 substrate binding site [chemical binding]; other site 694427006586 CoA binding site [chemical binding]; other site 694427006587 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 694427006588 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 694427006589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 694427006590 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 694427006591 putative hydrophobic ligand binding site [chemical binding]; other site 694427006592 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 694427006593 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 694427006594 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 694427006595 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 694427006596 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 694427006597 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 694427006598 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 694427006599 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 694427006600 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 694427006601 acyl-activating enzyme (AAE) consensus motif; other site 694427006602 acyl-activating enzyme (AAE) consensus motif; other site 694427006603 putative AMP binding site [chemical binding]; other site 694427006604 putative active site [active] 694427006605 putative CoA binding site [chemical binding]; other site 694427006606 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 694427006607 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427006608 ligand binding site [chemical binding]; other site 694427006609 Domain of unknown function DUF59; Region: DUF59; pfam01883 694427006610 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 694427006611 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 694427006612 Walker A motif; other site 694427006613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427006614 S-adenosylmethionine binding site [chemical binding]; other site 694427006615 GldH lipoprotein; Region: GldH_lipo; pfam14109 694427006616 PSP1 C-terminal conserved region; Region: PSP1; cl00770 694427006617 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 694427006618 DNA polymerase III subunit delta'; Validated; Region: PRK08485 694427006619 NigD-like protein; Region: NigD; pfam12667 694427006620 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 694427006621 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 694427006622 metal binding site [ion binding]; metal-binding site 694427006623 dimer interface [polypeptide binding]; other site 694427006624 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 694427006625 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 694427006626 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427006627 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 694427006628 E3 interaction surface; other site 694427006629 lipoyl attachment site [posttranslational modification]; other site 694427006630 HlyD family secretion protein; Region: HlyD_3; pfam13437 694427006631 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 694427006632 Protein export membrane protein; Region: SecD_SecF; cl14618 694427006633 Outer membrane efflux protein; Region: OEP; pfam02321 694427006634 Outer membrane efflux protein; Region: OEP; pfam02321 694427006635 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 694427006636 MarR family; Region: MarR_2; cl17246 694427006637 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 694427006638 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 694427006639 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 694427006640 tetramer interfaces [polypeptide binding]; other site 694427006641 binuclear metal-binding site [ion binding]; other site 694427006642 GtrA-like protein; Region: GtrA; pfam04138 694427006643 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427006644 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 694427006645 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 694427006646 active site 694427006647 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 694427006648 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 694427006649 Zn2+ binding site [ion binding]; other site 694427006650 Mg2+ binding site [ion binding]; other site 694427006651 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 694427006652 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 694427006653 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 694427006654 trimer interface [polypeptide binding]; other site 694427006655 active site 694427006656 UDP-GlcNAc binding site [chemical binding]; other site 694427006657 lipid binding site [chemical binding]; lipid-binding site 694427006658 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 694427006659 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 694427006660 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 694427006661 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 694427006662 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 694427006663 active site 694427006664 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 694427006665 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427006666 active site 694427006667 HIGH motif; other site 694427006668 nucleotide binding site [chemical binding]; other site 694427006669 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 694427006670 KMSKS motif; other site 694427006671 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 694427006672 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 694427006673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427006674 active site 694427006675 phosphorylation site [posttranslational modification] 694427006676 intermolecular recognition site; other site 694427006677 dimerization interface [polypeptide binding]; other site 694427006678 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694427006679 DNA binding site [nucleotide binding] 694427006680 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 694427006681 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 694427006682 active site 694427006683 nucleophile elbow; other site 694427006684 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 694427006685 dimer interface [polypeptide binding]; other site 694427006686 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 694427006687 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 694427006688 ligand binding site [chemical binding]; other site 694427006689 flexible hinge region; other site 694427006690 DNA topoisomerase I; Validated; Region: PRK06599 694427006691 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 694427006692 active site 694427006693 interdomain interaction site; other site 694427006694 putative metal-binding site [ion binding]; other site 694427006695 nucleotide binding site [chemical binding]; other site 694427006696 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 694427006697 domain I; other site 694427006698 DNA binding groove [nucleotide binding] 694427006699 phosphate binding site [ion binding]; other site 694427006700 domain II; other site 694427006701 domain III; other site 694427006702 nucleotide binding site [chemical binding]; other site 694427006703 catalytic site [active] 694427006704 domain IV; other site 694427006705 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 694427006706 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 694427006707 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 694427006708 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 694427006709 ribonuclease R; Region: RNase_R; TIGR02063 694427006710 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 694427006711 RNB domain; Region: RNB; pfam00773 694427006712 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 694427006713 RNA binding site [nucleotide binding]; other site 694427006714 GTP-binding protein LepA; Provisional; Region: PRK05433 694427006715 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 694427006716 G1 box; other site 694427006717 putative GEF interaction site [polypeptide binding]; other site 694427006718 GTP/Mg2+ binding site [chemical binding]; other site 694427006719 Switch I region; other site 694427006720 G2 box; other site 694427006721 G3 box; other site 694427006722 Switch II region; other site 694427006723 G4 box; other site 694427006724 G5 box; other site 694427006725 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 694427006726 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 694427006727 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 694427006728 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 694427006729 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 694427006730 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 694427006731 alpha subunit interaction interface [polypeptide binding]; other site 694427006732 Walker A motif; other site 694427006733 ATP binding site [chemical binding]; other site 694427006734 Walker B motif; other site 694427006735 inhibitor binding site; inhibition site 694427006736 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 694427006737 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 694427006738 gamma subunit interface [polypeptide binding]; other site 694427006739 LBP interface [polypeptide binding]; other site 694427006740 ATP synthase A chain; Region: ATP-synt_A; cl00413 694427006741 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 694427006742 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 694427006743 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 694427006744 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 694427006745 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 694427006746 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 694427006747 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 694427006748 beta subunit interaction interface [polypeptide binding]; other site 694427006749 Walker A motif; other site 694427006750 ATP binding site [chemical binding]; other site 694427006751 Walker B motif; other site 694427006752 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 694427006753 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 694427006754 core domain interface [polypeptide binding]; other site 694427006755 delta subunit interface [polypeptide binding]; other site 694427006756 epsilon subunit interface [polypeptide binding]; other site 694427006757 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427006758 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427006759 binding surface 694427006760 TPR motif; other site 694427006761 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427006762 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427006763 binding surface 694427006764 TPR motif; other site 694427006765 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427006766 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427006767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427006768 binding surface 694427006769 TPR motif; other site 694427006770 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427006771 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427006772 binding surface 694427006773 TPR motif; other site 694427006774 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427006775 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427006776 Histidine kinase; Region: His_kinase; pfam06580 694427006777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427006778 ATP binding site [chemical binding]; other site 694427006779 Mg2+ binding site [ion binding]; other site 694427006780 G-X-G motif; other site 694427006781 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 694427006782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427006783 active site 694427006784 phosphorylation site [posttranslational modification] 694427006785 intermolecular recognition site; other site 694427006786 dimerization interface [polypeptide binding]; other site 694427006787 LytTr DNA-binding domain; Region: LytTR; cl04498 694427006788 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 694427006789 S17 interaction site [polypeptide binding]; other site 694427006790 S8 interaction site; other site 694427006791 16S rRNA interaction site [nucleotide binding]; other site 694427006792 streptomycin interaction site [chemical binding]; other site 694427006793 23S rRNA interaction site [nucleotide binding]; other site 694427006794 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 694427006795 30S ribosomal protein S7; Validated; Region: PRK05302 694427006796 elongation factor G; Reviewed; Region: PRK12739 694427006797 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 694427006798 G1 box; other site 694427006799 putative GEF interaction site [polypeptide binding]; other site 694427006800 GTP/Mg2+ binding site [chemical binding]; other site 694427006801 Switch I region; other site 694427006802 G2 box; other site 694427006803 G3 box; other site 694427006804 Switch II region; other site 694427006805 G4 box; other site 694427006806 G5 box; other site 694427006807 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 694427006808 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 694427006809 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 694427006810 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 694427006811 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 694427006812 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 694427006813 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 694427006814 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 694427006815 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 694427006816 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 694427006817 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 694427006818 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 694427006819 putative translocon binding site; other site 694427006820 protein-rRNA interface [nucleotide binding]; other site 694427006821 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 694427006822 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 694427006823 G-X-X-G motif; other site 694427006824 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 694427006825 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 694427006826 23S rRNA interface [nucleotide binding]; other site 694427006827 5S rRNA interface [nucleotide binding]; other site 694427006828 putative antibiotic binding site [chemical binding]; other site 694427006829 L25 interface [polypeptide binding]; other site 694427006830 L27 interface [polypeptide binding]; other site 694427006831 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 694427006832 putative translocon interaction site; other site 694427006833 23S rRNA interface [nucleotide binding]; other site 694427006834 signal recognition particle (SRP54) interaction site; other site 694427006835 L23 interface [polypeptide binding]; other site 694427006836 trigger factor interaction site; other site 694427006837 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 694427006838 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 694427006839 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 694427006840 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 694427006841 RNA binding site [nucleotide binding]; other site 694427006842 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 694427006843 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 694427006844 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 694427006845 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 694427006846 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 694427006847 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 694427006848 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 694427006849 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 694427006850 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 694427006851 23S rRNA interface [nucleotide binding]; other site 694427006852 L21e interface [polypeptide binding]; other site 694427006853 5S rRNA interface [nucleotide binding]; other site 694427006854 L27 interface [polypeptide binding]; other site 694427006855 L5 interface [polypeptide binding]; other site 694427006856 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 694427006857 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 694427006858 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 694427006859 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 694427006860 23S rRNA binding site [nucleotide binding]; other site 694427006861 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 694427006862 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 694427006863 SecY translocase; Region: SecY; pfam00344 694427006864 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 694427006865 active site 694427006866 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 694427006867 rRNA binding site [nucleotide binding]; other site 694427006868 predicted 30S ribosome binding site; other site 694427006869 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 694427006870 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 694427006871 30S ribosomal protein S13; Region: bact_S13; TIGR03631 694427006872 30S ribosomal protein S11; Validated; Region: PRK05309 694427006873 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 694427006874 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 694427006875 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 694427006876 RNA binding surface [nucleotide binding]; other site 694427006877 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 694427006878 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 694427006879 alphaNTD - beta interaction site [polypeptide binding]; other site 694427006880 alphaNTD homodimer interface [polypeptide binding]; other site 694427006881 alphaNTD - beta' interaction site [polypeptide binding]; other site 694427006882 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 694427006883 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 694427006884 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 694427006885 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 694427006886 putative nucleotide binding site [chemical binding]; other site 694427006887 uridine monophosphate binding site [chemical binding]; other site 694427006888 homohexameric interface [polypeptide binding]; other site 694427006889 ribosome recycling factor; Reviewed; Region: frr; PRK00083 694427006890 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 694427006891 hinge region; other site 694427006892 GTPase RsgA; Reviewed; Region: PRK00098 694427006893 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 694427006894 RNA binding site [nucleotide binding]; other site 694427006895 homodimer interface [polypeptide binding]; other site 694427006896 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 694427006897 GTPase/Zn-binding domain interface [polypeptide binding]; other site 694427006898 GTP/Mg2+ binding site [chemical binding]; other site 694427006899 G4 box; other site 694427006900 G5 box; other site 694427006901 G1 box; other site 694427006902 Switch I region; other site 694427006903 G2 box; other site 694427006904 G3 box; other site 694427006905 Switch II region; other site 694427006906 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 694427006907 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 694427006908 putative DNA binding site [nucleotide binding]; other site 694427006909 putative Zn2+ binding site [ion binding]; other site 694427006910 AsnC family; Region: AsnC_trans_reg; pfam01037 694427006911 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 694427006912 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 694427006913 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 694427006914 KMSK motif region; other site 694427006915 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 694427006916 tRNA binding surface [nucleotide binding]; other site 694427006917 anticodon binding site; other site 694427006918 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 694427006919 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 694427006920 N-acetyl-D-glucosamine binding site [chemical binding]; other site 694427006921 catalytic residue [active] 694427006922 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 694427006923 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 694427006924 active site 694427006925 (T/H)XGH motif; other site 694427006926 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 694427006927 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 694427006928 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 694427006929 protein binding site [polypeptide binding]; other site 694427006930 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 694427006931 Catalytic dyad [active] 694427006932 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 694427006933 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694427006934 non-specific DNA binding site [nucleotide binding]; other site 694427006935 salt bridge; other site 694427006936 sequence-specific DNA binding site [nucleotide binding]; other site 694427006937 Cupin domain; Region: Cupin_2; pfam07883 694427006938 AMP-binding domain protein; Validated; Region: PRK08315 694427006939 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 694427006940 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 694427006941 acyl-activating enzyme (AAE) consensus motif; other site 694427006942 acyl-activating enzyme (AAE) consensus motif; other site 694427006943 putative AMP binding site [chemical binding]; other site 694427006944 putative active site [active] 694427006945 putative CoA binding site [chemical binding]; other site 694427006946 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 694427006947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427006948 S-adenosylmethionine binding site [chemical binding]; other site 694427006949 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 694427006950 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 694427006951 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 694427006952 gliding motility-associated lipoprotein GldK; Region: GldK; TIGR03525 694427006953 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 694427006954 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 694427006955 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 694427006956 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 694427006957 GldM N-terminal domain; Region: GldM_N; pfam12081 694427006958 GldM C-terminal domain; Region: GldM_C; pfam12080 694427006959 gliding motility associated protien GldN; Region: GldN; TIGR03523 694427006960 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 694427006961 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 694427006962 DNA binding residues [nucleotide binding] 694427006963 dimerization interface [polypeptide binding]; other site 694427006964 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 694427006965 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 694427006966 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 694427006967 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427006968 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427006969 DNA binding residues [nucleotide binding] 694427006970 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 694427006971 FecR protein; Region: FecR; pfam04773 694427006972 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427006973 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427006974 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 694427006975 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427006976 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 694427006977 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427006978 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 694427006979 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427006980 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427006981 catalytic residues [active] 694427006982 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 694427006983 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 694427006984 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 694427006985 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 694427006986 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 694427006987 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 694427006988 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427006989 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427006990 DNA binding residues [nucleotide binding] 694427006991 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 694427006992 FecR protein; Region: FecR; pfam04773 694427006993 Secretin and TonB N terminus short domain; Region: STN; pfam07660 694427006994 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427006995 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427006996 TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057 694427006997 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427006998 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 694427006999 SusD family; Region: SusD; pfam07980 694427007000 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427007001 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427007002 catalytic residues [active] 694427007003 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 694427007004 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 694427007005 nucleophilic elbow; other site 694427007006 catalytic triad; other site 694427007007 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 694427007008 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 694427007009 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 694427007010 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 694427007011 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 694427007012 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 694427007013 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427007014 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427007015 catalytic residues [active] 694427007016 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427007017 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427007018 catalytic residues [active] 694427007019 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 694427007020 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427007021 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427007022 DNA binding residues [nucleotide binding] 694427007023 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 694427007024 FecR protein; Region: FecR; pfam04773 694427007025 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427007026 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427007027 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 694427007028 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427007029 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 694427007030 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427007031 Tetratricopeptide repeat; Region: TPR_12; pfam13424 694427007032 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 694427007033 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427007034 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427007035 catalytic residues [active] 694427007036 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 694427007037 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 694427007038 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 694427007039 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 694427007040 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 694427007041 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 694427007042 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 694427007043 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 694427007044 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 694427007045 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 694427007046 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 694427007047 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 694427007048 active site residue [active] 694427007049 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 694427007050 active site residue [active] 694427007051 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 694427007052 active site residue [active] 694427007053 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 694427007054 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427007055 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427007056 DNA binding residues [nucleotide binding] 694427007057 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 694427007058 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 694427007059 Active Sites [active] 694427007060 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 694427007061 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 694427007062 CysD dimerization site [polypeptide binding]; other site 694427007063 G1 box; other site 694427007064 putative GEF interaction site [polypeptide binding]; other site 694427007065 GTP/Mg2+ binding site [chemical binding]; other site 694427007066 Switch I region; other site 694427007067 G2 box; other site 694427007068 G3 box; other site 694427007069 Switch II region; other site 694427007070 G4 box; other site 694427007071 G5 box; other site 694427007072 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 694427007073 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 694427007074 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 694427007075 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 694427007076 Active Sites [active] 694427007077 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 694427007078 Flavodoxin; Region: Flavodoxin_1; pfam00258 694427007079 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 694427007080 FAD binding pocket [chemical binding]; other site 694427007081 FAD binding motif [chemical binding]; other site 694427007082 catalytic residues [active] 694427007083 NAD binding pocket [chemical binding]; other site 694427007084 phosphate binding motif [ion binding]; other site 694427007085 beta-alpha-beta structure motif; other site 694427007086 sulfite reductase subunit beta; Provisional; Region: PRK13504 694427007087 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 694427007088 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 694427007089 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 694427007090 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 694427007091 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 694427007092 Two component regulator propeller; Region: Reg_prop; pfam07494 694427007093 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 694427007094 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 694427007095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 694427007096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427007097 dimer interface [polypeptide binding]; other site 694427007098 phosphorylation site [posttranslational modification] 694427007099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427007100 ATP binding site [chemical binding]; other site 694427007101 Mg2+ binding site [ion binding]; other site 694427007102 G-X-G motif; other site 694427007103 Response regulator receiver domain; Region: Response_reg; pfam00072 694427007104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427007105 active site 694427007106 phosphorylation site [posttranslational modification] 694427007107 intermolecular recognition site; other site 694427007108 dimerization interface [polypeptide binding]; other site 694427007109 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 694427007110 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427007111 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 694427007112 active site 694427007113 catalytic residues [active] 694427007114 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427007115 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427007116 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 694427007117 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427007118 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 694427007119 starch binding outer membrane protein SusD; Region: SusD; cl17845 694427007120 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 694427007121 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 694427007122 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 694427007123 Serine hydrolase; Region: Ser_hydrolase; pfam06821 694427007124 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 694427007125 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 694427007126 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 694427007127 putative active site [active] 694427007128 cobalt transport protein CbiM; Validated; Region: PRK08319 694427007129 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 694427007130 cobalt transport protein CbiN; Provisional; Region: PRK02898 694427007131 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 694427007132 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639 694427007133 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 694427007134 Walker A/P-loop; other site 694427007135 ATP binding site [chemical binding]; other site 694427007136 Q-loop/lid; other site 694427007137 ABC transporter signature motif; other site 694427007138 Walker B; other site 694427007139 D-loop; other site 694427007140 H-loop/switch region; other site 694427007141 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 694427007142 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 694427007143 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 694427007144 catalytic triad [active] 694427007145 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 694427007146 Precorrin-8X methylmutase; Region: CbiC; pfam02570 694427007147 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 694427007148 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 694427007149 active site 694427007150 putative homodimer interface [polypeptide binding]; other site 694427007151 SAM binding site [chemical binding]; other site 694427007152 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 694427007153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427007154 S-adenosylmethionine binding site [chemical binding]; other site 694427007155 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 694427007156 active site 694427007157 SAM binding site [chemical binding]; other site 694427007158 homodimer interface [polypeptide binding]; other site 694427007159 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 694427007160 active site 694427007161 SAM binding site [chemical binding]; other site 694427007162 homodimer interface [polypeptide binding]; other site 694427007163 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 694427007164 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 694427007165 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 694427007166 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 694427007167 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 694427007168 active site 694427007169 SAM binding site [chemical binding]; other site 694427007170 homodimer interface [polypeptide binding]; other site 694427007171 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 694427007172 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 694427007173 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 694427007174 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 694427007175 Walker A motif; other site 694427007176 homodimer interface [polypeptide binding]; other site 694427007177 ATP binding site [chemical binding]; other site 694427007178 hydroxycobalamin binding site [chemical binding]; other site 694427007179 Walker B motif; other site 694427007180 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 694427007181 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 694427007182 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 694427007183 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 694427007184 active site 694427007185 SAM binding site [chemical binding]; other site 694427007186 homodimer interface [polypeptide binding]; other site 694427007187 protoporphyrinogen oxidase; Region: PLN02576 694427007188 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 694427007189 Ferrochelatase; Region: Ferrochelatase; pfam00762 694427007190 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 694427007191 C-terminal domain interface [polypeptide binding]; other site 694427007192 active site 694427007193 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 694427007194 active site 694427007195 N-terminal domain interface [polypeptide binding]; other site 694427007196 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 694427007197 HemN C-terminal domain; Region: HemN_C; pfam06969 694427007198 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 694427007199 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 694427007200 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 694427007201 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 694427007202 inhibitor-cofactor binding pocket; inhibition site 694427007203 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427007204 catalytic residue [active] 694427007205 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 694427007206 dimer interface [polypeptide binding]; other site 694427007207 active site 694427007208 Schiff base residues; other site 694427007209 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 694427007210 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 694427007211 active site 694427007212 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 694427007213 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 694427007214 domain interfaces; other site 694427007215 active site 694427007216 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 694427007217 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 694427007218 tRNA; other site 694427007219 putative tRNA binding site [nucleotide binding]; other site 694427007220 putative NADP binding site [chemical binding]; other site 694427007221 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 694427007222 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 694427007223 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 694427007224 homodimer interface [polypeptide binding]; other site 694427007225 substrate-cofactor binding pocket; other site 694427007226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427007227 catalytic residue [active] 694427007228 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 694427007229 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 694427007230 dimer interface [polypeptide binding]; other site 694427007231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427007232 catalytic residue [active] 694427007233 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 694427007234 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 694427007235 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 694427007236 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 694427007237 ABC transporter; Region: ABC_tran_2; pfam12848 694427007238 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 694427007239 KilA-N domain; Region: KilA-N; pfam04383 694427007240 Rubrerythrin [Energy production and conversion]; Region: COG1592 694427007241 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 694427007242 binuclear metal center [ion binding]; other site 694427007243 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 694427007244 iron binding site [ion binding]; other site 694427007245 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 694427007246 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 694427007247 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 694427007248 active site 694427007249 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 694427007250 16S/18S rRNA binding site [nucleotide binding]; other site 694427007251 S13e-L30e interaction site [polypeptide binding]; other site 694427007252 25S rRNA binding site [nucleotide binding]; other site 694427007253 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 694427007254 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 694427007255 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 694427007256 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 694427007257 dimer interface [polypeptide binding]; other site 694427007258 motif 1; other site 694427007259 active site 694427007260 motif 2; other site 694427007261 motif 3; other site 694427007262 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 694427007263 anticodon binding site; other site 694427007264 Protein of unknown function (DUF456); Region: DUF456; pfam04306 694427007265 LytTr DNA-binding domain; Region: LytTR; smart00850 694427007266 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 694427007267 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 694427007268 active site 694427007269 nucleophile elbow; other site 694427007270 aspartate aminotransferase; Provisional; Region: PRK05764 694427007271 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694427007272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427007273 homodimer interface [polypeptide binding]; other site 694427007274 catalytic residue [active] 694427007275 HEPN domain; Region: HEPN; cl00824 694427007276 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 694427007277 DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201 694427007278 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 694427007279 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 694427007280 active site 694427007281 catalytic tetrad [active] 694427007282 PAS domain; Region: PAS_9; pfam13426 694427007283 Phosphoglycerate kinase; Region: PGK; pfam00162 694427007284 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 694427007285 substrate binding site [chemical binding]; other site 694427007286 hinge regions; other site 694427007287 ADP binding site [chemical binding]; other site 694427007288 catalytic site [active] 694427007289 malate dehydrogenase; Reviewed; Region: PRK06223 694427007290 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 694427007291 dimer interface [polypeptide binding]; other site 694427007292 NAD(P) binding site [chemical binding]; other site 694427007293 tetramer (dimer of dimers) interface [polypeptide binding]; other site 694427007294 substrate binding site [chemical binding]; other site 694427007295 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427007296 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 694427007297 metal binding site 2 [ion binding]; metal-binding site 694427007298 putative DNA binding helix; other site 694427007299 metal binding site 1 [ion binding]; metal-binding site 694427007300 dimer interface [polypeptide binding]; other site 694427007301 structural Zn2+ binding site [ion binding]; other site 694427007302 Surface antigen; Region: Bac_surface_Ag; pfam01103 694427007303 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 694427007304 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427007305 active site 694427007306 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 694427007307 iron-sulfur cluster [ion binding]; other site 694427007308 [2Fe-2S] cluster binding site [ion binding]; other site 694427007309 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 694427007310 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 694427007311 active site 694427007312 catalytic tetrad [active] 694427007313 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 694427007314 Repair protein; Region: Repair_PSII; pfam04536 694427007315 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 694427007316 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 694427007317 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 694427007318 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 694427007319 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 694427007320 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 694427007321 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 694427007322 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 694427007323 YceI-like domain; Region: YceI; cl01001 694427007324 YceI-like domain; Region: YceI; pfam04264 694427007325 Rrf2 family protein; Region: rrf2_super; TIGR00738 694427007326 Transcriptional regulator; Region: Rrf2; pfam02082 694427007327 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 694427007328 diiron binding motif [ion binding]; other site 694427007329 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 694427007330 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 694427007331 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 694427007332 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 694427007333 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 694427007334 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 694427007335 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 694427007336 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427007337 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 694427007338 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 694427007339 CsbD-like; Region: CsbD; cl17424 694427007340 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 694427007341 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 694427007342 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427007343 ligand binding site [chemical binding]; other site 694427007344 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 694427007345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427007346 active site 694427007347 phosphorylation site [posttranslational modification] 694427007348 intermolecular recognition site; other site 694427007349 PAS fold; Region: PAS; pfam00989 694427007350 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427007351 putative active site [active] 694427007352 heme pocket [chemical binding]; other site 694427007353 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 694427007354 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427007355 putative active site [active] 694427007356 heme pocket [chemical binding]; other site 694427007357 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427007358 dimer interface [polypeptide binding]; other site 694427007359 phosphorylation site [posttranslational modification] 694427007360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427007361 ATP binding site [chemical binding]; other site 694427007362 Mg2+ binding site [ion binding]; other site 694427007363 G-X-G motif; other site 694427007364 Response regulator receiver domain; Region: Response_reg; pfam00072 694427007365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427007366 active site 694427007367 phosphorylation site [posttranslational modification] 694427007368 intermolecular recognition site; other site 694427007369 dimerization interface [polypeptide binding]; other site 694427007370 Helix-turn-helix domain; Region: HTH_18; pfam12833 694427007371 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427007372 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 694427007373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427007374 Walker A/P-loop; other site 694427007375 ATP binding site [chemical binding]; other site 694427007376 Q-loop/lid; other site 694427007377 ABC transporter signature motif; other site 694427007378 Walker B; other site 694427007379 D-loop; other site 694427007380 H-loop/switch region; other site 694427007381 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 694427007382 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 694427007383 Peptidase family M28; Region: Peptidase_M28; pfam04389 694427007384 metal binding site [ion binding]; metal-binding site 694427007385 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 694427007386 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 694427007387 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 694427007388 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 694427007389 Ycf48-like protein; Provisional; Region: PRK13684 694427007390 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 694427007391 Surface antigen; Region: Bac_surface_Ag; pfam01103 694427007392 AsmA family; Region: AsmA; pfam05170 694427007393 Family of unknown function (DUF490); Region: DUF490; pfam04357 694427007394 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 694427007395 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 694427007396 FMN binding site [chemical binding]; other site 694427007397 active site 694427007398 substrate binding site [chemical binding]; other site 694427007399 catalytic residue [active] 694427007400 LytTr DNA-binding domain; Region: LytTR; pfam04397 694427007401 AAA ATPase domain; Region: AAA_15; pfam13175 694427007402 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427007403 Walker A/P-loop; other site 694427007404 ATP binding site [chemical binding]; other site 694427007405 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 694427007406 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 694427007407 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 694427007408 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 694427007409 Soluble P-type ATPase [General function prediction only]; Region: COG4087 694427007410 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 694427007411 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 694427007412 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 694427007413 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 694427007414 Ligand Binding Site [chemical binding]; other site 694427007415 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 694427007416 GAF domain; Region: GAF_3; pfam13492 694427007417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427007418 dimer interface [polypeptide binding]; other site 694427007419 phosphorylation site [posttranslational modification] 694427007420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427007421 ATP binding site [chemical binding]; other site 694427007422 Mg2+ binding site [ion binding]; other site 694427007423 G-X-G motif; other site 694427007424 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 694427007425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427007426 active site 694427007427 phosphorylation site [posttranslational modification] 694427007428 intermolecular recognition site; other site 694427007429 dimerization interface [polypeptide binding]; other site 694427007430 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694427007431 DNA binding site [nucleotide binding] 694427007432 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 694427007433 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694427007434 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 694427007435 active site 694427007436 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 694427007437 Domain of unknown function DUF20; Region: UPF0118; pfam01594 694427007438 YtxH-like protein; Region: YtxH; pfam12732 694427007439 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 694427007440 Flagellin N-methylase; Region: FliB; pfam03692 694427007441 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 694427007442 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 694427007443 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 694427007444 Zn2+ binding site [ion binding]; other site 694427007445 Mg2+ binding site [ion binding]; other site 694427007446 Cell division protein ZapA; Region: ZapA; pfam05164 694427007447 putative transporter; Provisional; Region: PRK11660 694427007448 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 694427007449 Sulfate transporter family; Region: Sulfate_transp; pfam00916 694427007450 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 694427007451 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 694427007452 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048 694427007453 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 694427007454 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 694427007455 active site 694427007456 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 694427007457 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 694427007458 motif 1; other site 694427007459 active site 694427007460 motif 2; other site 694427007461 motif 3; other site 694427007462 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 694427007463 DHHA1 domain; Region: DHHA1; pfam02272 694427007464 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 694427007465 Peptidase family M23; Region: Peptidase_M23; pfam01551 694427007466 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 694427007467 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 694427007468 putative active site [active] 694427007469 putative metal binding site [ion binding]; other site 694427007470 glutamate racemase; Provisional; Region: PRK00865 694427007471 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 694427007472 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 694427007473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427007474 active site 694427007475 phosphorylation site [posttranslational modification] 694427007476 intermolecular recognition site; other site 694427007477 dimerization interface [polypeptide binding]; other site 694427007478 LytTr DNA-binding domain; Region: LytTR; smart00850 694427007479 Targeting protein for Xklp2 (TPX2); Region: TPX2; pfam06886 694427007480 Histidine kinase; Region: His_kinase; pfam06580 694427007481 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694427007482 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 694427007483 FtsX-like permease family; Region: FtsX; pfam02687 694427007484 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 694427007485 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 694427007486 Walker A/P-loop; other site 694427007487 ATP binding site [chemical binding]; other site 694427007488 Q-loop/lid; other site 694427007489 ABC transporter signature motif; other site 694427007490 Walker B; other site 694427007491 D-loop; other site 694427007492 H-loop/switch region; other site 694427007493 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 694427007494 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 694427007495 HlyD family secretion protein; Region: HlyD_3; pfam13437 694427007496 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 694427007497 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 694427007498 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 694427007499 prephenate dehydrogenase; Validated; Region: PRK08507 694427007500 muropeptide transporter; Validated; Region: ampG; cl17669 694427007501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427007502 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 694427007503 putative active site [active] 694427007504 Stage II sporulation protein; Region: SpoIID; pfam08486 694427007505 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 694427007506 GDP-L-galactose-hexose-1-phosphate guanyltransferase; Provisional; Region: PLN03103 694427007507 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694427007508 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 694427007509 active site 694427007510 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 694427007511 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427007512 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 694427007513 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 694427007514 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 694427007515 putative active site [active] 694427007516 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 694427007517 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 694427007518 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 694427007519 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 694427007520 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 694427007521 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 694427007522 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 694427007523 hypothetical protein; Reviewed; Region: PRK12275 694427007524 four helix bundle protein; Region: TIGR02436 694427007525 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 694427007526 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427007527 Walker A/P-loop; other site 694427007528 ATP binding site [chemical binding]; other site 694427007529 Q-loop/lid; other site 694427007530 ABC transporter signature motif; other site 694427007531 Walker B; other site 694427007532 D-loop; other site 694427007533 H-loop/switch region; other site 694427007534 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 694427007535 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 694427007536 Walker A/P-loop; other site 694427007537 ATP binding site [chemical binding]; other site 694427007538 Q-loop/lid; other site 694427007539 ABC transporter signature motif; other site 694427007540 Walker B; other site 694427007541 D-loop; other site 694427007542 H-loop/switch region; other site 694427007543 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427007544 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 694427007545 HlyD family secretion protein; Region: HlyD_3; pfam13437 694427007546 Outer membrane efflux protein; Region: OEP; pfam02321 694427007547 Outer membrane efflux protein; Region: OEP; pfam02321 694427007548 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 694427007549 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 694427007550 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 694427007551 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427007552 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 694427007553 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427007554 putative carbohydrate kinase; Provisional; Region: PRK10565 694427007555 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 694427007556 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 694427007557 putative substrate binding site [chemical binding]; other site 694427007558 putative ATP binding site [chemical binding]; other site 694427007559 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 694427007560 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 694427007561 active site 694427007562 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 694427007563 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 694427007564 S-adenosylmethionine binding site [chemical binding]; other site 694427007565 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 694427007566 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 694427007567 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 694427007568 active site 694427007569 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 694427007570 Protein export membrane protein; Region: SecD_SecF; cl14618 694427007571 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427007572 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 694427007573 HlyD family secretion protein; Region: HlyD_3; pfam13437 694427007574 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 694427007575 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 694427007576 MarR family; Region: MarR_2; pfam12802 694427007577 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694427007578 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 694427007579 HlyD family secretion protein; Region: HlyD_3; pfam13437 694427007580 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 694427007581 gag-polypeptide of LTR copia-type; Region: UBN2; cl15874 694427007582 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 694427007583 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427007584 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427007585 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 694427007586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427007587 active site 694427007588 phosphorylation site [posttranslational modification] 694427007589 intermolecular recognition site; other site 694427007590 dimerization interface [polypeptide binding]; other site 694427007591 LytTr DNA-binding domain; Region: LytTR; smart00850 694427007592 Response regulator receiver domain; Region: Response_reg; pfam00072 694427007593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427007594 active site 694427007595 phosphorylation site [posttranslational modification] 694427007596 dimerization interface [polypeptide binding]; other site 694427007597 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427007598 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 694427007599 putative active site [active] 694427007600 heme pocket [chemical binding]; other site 694427007601 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427007602 putative active site [active] 694427007603 heme pocket [chemical binding]; other site 694427007604 PAS domain S-box; Region: sensory_box; TIGR00229 694427007605 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427007606 putative active site [active] 694427007607 heme pocket [chemical binding]; other site 694427007608 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427007609 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 694427007610 putative active site [active] 694427007611 heme pocket [chemical binding]; other site 694427007612 PAS domain; Region: PAS_8; pfam13188 694427007613 PAS domain S-box; Region: sensory_box; TIGR00229 694427007614 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427007615 putative active site [active] 694427007616 heme pocket [chemical binding]; other site 694427007617 Histidine kinase; Region: His_kinase; pfam06580 694427007618 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427007619 PAS domain; Region: PAS_9; pfam13426 694427007620 putative active site [active] 694427007621 heme pocket [chemical binding]; other site 694427007622 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 694427007623 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 694427007624 substrate binding pocket [chemical binding]; other site 694427007625 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 694427007626 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 694427007627 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 694427007628 nucleotide binding site [chemical binding]; other site 694427007629 NEF interaction site [polypeptide binding]; other site 694427007630 SBD interface [polypeptide binding]; other site 694427007631 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 694427007632 catalytic center binding site [active] 694427007633 ATP binding site [chemical binding]; other site 694427007634 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 694427007635 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 694427007636 catalytic site [active] 694427007637 putative active site [active] 694427007638 putative substrate binding site [chemical binding]; other site 694427007639 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 694427007640 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 694427007641 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 694427007642 putative RNA binding site [nucleotide binding]; other site 694427007643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427007644 S-adenosylmethionine binding site [chemical binding]; other site 694427007645 RNA polymerase sigma factor; Provisional; Region: PRK12513 694427007646 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694427007647 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694427007648 DNA binding residues [nucleotide binding] 694427007649 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 694427007650 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 694427007651 substrate binding site [chemical binding]; other site 694427007652 hexamer interface [polypeptide binding]; other site 694427007653 metal binding site [ion binding]; metal-binding site 694427007654 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 694427007655 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 694427007656 Competence protein; Region: Competence; pfam03772 694427007657 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 694427007658 DHH family; Region: DHH; pfam01368 694427007659 DHHA1 domain; Region: DHHA1; pfam02272 694427007660 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 694427007661 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 694427007662 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 694427007663 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 694427007664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427007665 catalytic residue [active] 694427007666 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 694427007667 amidase catalytic site [active] 694427007668 Zn binding residues [ion binding]; other site 694427007669 substrate binding site [chemical binding]; other site 694427007670 Predicted membrane protein [Function unknown]; Region: COG1238 694427007671 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 694427007672 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 694427007673 active site 694427007674 Zn binding site [ion binding]; other site 694427007675 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 694427007676 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 694427007677 active site 694427007678 Riboflavin kinase; Region: Flavokinase; pfam01687 694427007679 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694427007680 motif II; other site 694427007681 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 694427007682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427007683 active site 694427007684 phosphorylation site [posttranslational modification] 694427007685 intermolecular recognition site; other site 694427007686 dimerization interface [polypeptide binding]; other site 694427007687 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694427007688 DNA binding site [nucleotide binding] 694427007689 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 694427007690 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694427007691 dimer interface [polypeptide binding]; other site 694427007692 phosphorylation site [posttranslational modification] 694427007693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427007694 ATP binding site [chemical binding]; other site 694427007695 Mg2+ binding site [ion binding]; other site 694427007696 G-X-G motif; other site 694427007697 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 694427007698 active site 694427007699 PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and...; Region: PLAT; cl00011 694427007700 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 694427007701 Bacterial SH3 domain; Region: SH3_3; pfam08239 694427007702 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 694427007703 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 694427007704 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 694427007705 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 694427007706 active site 694427007707 catalytic residues [active] 694427007708 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 694427007709 Na binding site [ion binding]; other site 694427007710 ribulokinase; Provisional; Region: PRK04123 694427007711 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 694427007712 N- and C-terminal domain interface [polypeptide binding]; other site 694427007713 active site 694427007714 MgATP binding site [chemical binding]; other site 694427007715 catalytic site [active] 694427007716 metal binding site [ion binding]; metal-binding site 694427007717 carbohydrate binding site [chemical binding]; other site 694427007718 homodimer interface [polypeptide binding]; other site 694427007719 L-arabinose isomerase; Provisional; Region: PRK02929 694427007720 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 694427007721 hexamer (dimer of trimers) interface [polypeptide binding]; other site 694427007722 trimer interface [polypeptide binding]; other site 694427007723 substrate binding site [chemical binding]; other site 694427007724 Mn binding site [ion binding]; other site 694427007725 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 694427007726 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 694427007727 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 694427007728 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 694427007729 intersubunit interface [polypeptide binding]; other site 694427007730 active site 694427007731 Zn2+ binding site [ion binding]; other site 694427007732 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 694427007733 nudix motif; other site 694427007734 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 694427007735 Peptidase S46; Region: Peptidase_S46; pfam10459 694427007736 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 694427007737 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 694427007738 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427007739 Walker A/P-loop; other site 694427007740 ATP binding site [chemical binding]; other site 694427007741 Q-loop/lid; other site 694427007742 ABC transporter signature motif; other site 694427007743 Walker B; other site 694427007744 D-loop; other site 694427007745 H-loop/switch region; other site 694427007746 ABC transporter; Region: ABC_tran_2; pfam12848 694427007747 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 694427007748 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 694427007749 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 694427007750 substrate-cofactor binding pocket; other site 694427007751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427007752 catalytic residue [active] 694427007753 Flagellin N-methylase; Region: FliB; pfam03692 694427007754 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 694427007755 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 694427007756 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427007757 Walker A/P-loop; other site 694427007758 ATP binding site [chemical binding]; other site 694427007759 Q-loop/lid; other site 694427007760 ABC transporter signature motif; other site 694427007761 Walker B; other site 694427007762 D-loop; other site 694427007763 H-loop/switch region; other site 694427007764 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 694427007765 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 694427007766 hinge; other site 694427007767 active site 694427007768 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 694427007769 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 694427007770 dimer interface [polypeptide binding]; other site 694427007771 active site 694427007772 metal binding site [ion binding]; metal-binding site 694427007773 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 694427007774 putative trimer interface [polypeptide binding]; other site 694427007775 putative CoA binding site [chemical binding]; other site 694427007776 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 694427007777 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 694427007778 HflX GTPase family; Region: HflX; cd01878 694427007779 G1 box; other site 694427007780 GTP/Mg2+ binding site [chemical binding]; other site 694427007781 Switch I region; other site 694427007782 G2 box; other site 694427007783 G3 box; other site 694427007784 Switch II region; other site 694427007785 G4 box; other site 694427007786 G5 box; other site 694427007787 cytidylate kinase; Provisional; Region: cmk; PRK00023 694427007788 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 694427007789 CMP-binding site; other site 694427007790 The sites determining sugar specificity; other site 694427007791 LytB protein; Region: LYTB; cl00507 694427007792 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 694427007793 6-phosphofructokinase; Provisional; Region: PRK03202 694427007794 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 694427007795 active site 694427007796 ADP/pyrophosphate binding site [chemical binding]; other site 694427007797 dimerization interface [polypeptide binding]; other site 694427007798 allosteric effector site; other site 694427007799 fructose-1,6-bisphosphate binding site; other site 694427007800 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 694427007801 Low molecular weight phosphatase family; Region: LMWPc; cd00115 694427007802 active site 694427007803 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 694427007804 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 694427007805 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 694427007806 shikimate binding site; other site 694427007807 NAD(P) binding site [chemical binding]; other site 694427007808 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 694427007809 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 694427007810 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 694427007811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427007812 binding surface 694427007813 TPR motif; other site 694427007814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427007815 binding surface 694427007816 TPR motif; other site 694427007817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427007818 TPR motif; other site 694427007819 binding surface 694427007820 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427007821 TPR motif; other site 694427007822 binding surface 694427007823 Ribosomal protein L37e; Region: Ribosomal_L37e; cl00932 694427007824 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 694427007825 nudix motif; other site 694427007826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427007827 binding surface 694427007828 TPR motif; other site 694427007829 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427007830 binding surface 694427007831 TPR motif; other site 694427007832 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 694427007833 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427007834 binding surface 694427007835 TPR motif; other site 694427007836 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 694427007837 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 694427007838 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427007839 Uncharacterized conserved protein [Function unknown]; Region: COG4748 694427007840 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 694427007841 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 694427007842 putative oxidoreductase; Provisional; Region: PRK12831 694427007843 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 694427007844 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 694427007845 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 694427007846 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 694427007847 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 694427007848 FAD binding pocket [chemical binding]; other site 694427007849 FAD binding motif [chemical binding]; other site 694427007850 phosphate binding motif [ion binding]; other site 694427007851 beta-alpha-beta structure motif; other site 694427007852 NAD binding pocket [chemical binding]; other site 694427007853 Iron coordination center [ion binding]; other site 694427007854 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 694427007855 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 694427007856 N-terminal plug; other site 694427007857 ligand-binding site [chemical binding]; other site 694427007858 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 694427007859 SPFH domain / Band 7 family; Region: Band_7; pfam01145 694427007860 Transcriptional regulators [Transcription]; Region: MarR; COG1846 694427007861 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 694427007862 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 694427007863 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 694427007864 putative active site; other site 694427007865 catalytic triad [active] 694427007866 putative dimer interface [polypeptide binding]; other site 694427007867 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 694427007868 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 694427007869 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 694427007870 Ligand Binding Site [chemical binding]; other site 694427007871 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 694427007872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694427007873 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 694427007874 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 694427007875 dimer interface [polypeptide binding]; other site 694427007876 active site 694427007877 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 694427007878 catalytic residues [active] 694427007879 substrate binding site [chemical binding]; other site 694427007880 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 694427007881 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694427007882 ATP binding site [chemical binding]; other site 694427007883 putative Mg++ binding site [ion binding]; other site 694427007884 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694427007885 nucleotide binding region [chemical binding]; other site 694427007886 ATP-binding site [chemical binding]; other site 694427007887 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 694427007888 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 694427007889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427007890 binding surface 694427007891 TPR motif; other site 694427007892 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 694427007893 binding surface 694427007894 TPR motif; other site 694427007895 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 694427007896 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 694427007897 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 694427007898 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 694427007899 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 694427007900 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 694427007901 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 694427007902 Penicillinase repressor; Region: Pencillinase_R; pfam03965 694427007903 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427007904 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427007905 catalytic residues [active] 694427007906 Peptidase S8 family domain, uncharacterized subfamily 9; Region: Peptidases_S8_9; cd07493 694427007907 active site 694427007908 catalytic triad [active] 694427007909 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 694427007910 generic binding surface II; other site 694427007911 generic binding surface I; other site 694427007912 Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601 694427007913 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 694427007914 homooctamer interface [polypeptide binding]; other site 694427007915 active site 694427007916 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 694427007917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427007918 putative substrate translocation pore; other site 694427007919 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 694427007920 active site 694427007921 metal binding site [ion binding]; metal-binding site 694427007922 homotetramer interface [polypeptide binding]; other site 694427007923 Peptidase family M23; Region: Peptidase_M23; pfam01551 694427007924 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 694427007925 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 694427007926 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 694427007927 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 694427007928 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 694427007929 RIP metalloprotease RseP; Region: TIGR00054 694427007930 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 694427007931 active site 694427007932 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 694427007933 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 694427007934 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 694427007935 putative substrate binding region [chemical binding]; other site 694427007936 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 694427007937 ArsC family; Region: ArsC; pfam03960 694427007938 putative ArsC-like catalytic residues; other site 694427007939 putative TRX-like catalytic residues [active] 694427007940 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427007941 FeS/SAM binding site; other site 694427007942 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 694427007943 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427007944 binding surface 694427007945 Tetratricopeptide repeat; Region: TPR_16; pfam13432 694427007946 TPR motif; other site 694427007947 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 694427007948 FtsH Extracellular; Region: FtsH_ext; pfam06480 694427007949 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 694427007950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427007951 Walker A motif; other site 694427007952 ATP binding site [chemical binding]; other site 694427007953 Walker B motif; other site 694427007954 arginine finger; other site 694427007955 Peptidase family M41; Region: Peptidase_M41; pfam01434 694427007956 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427007957 ligand binding site [chemical binding]; other site 694427007958 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 694427007959 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 694427007960 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 694427007961 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 694427007962 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 694427007963 dimer interface [polypeptide binding]; other site 694427007964 active site 694427007965 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 694427007966 catalytic residues [active] 694427007967 substrate binding site [chemical binding]; other site 694427007968 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 694427007969 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694427007970 salt bridge; other site 694427007971 non-specific DNA binding site [nucleotide binding]; other site 694427007972 sequence-specific DNA binding site [nucleotide binding]; other site 694427007973 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 694427007974 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 694427007975 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 694427007976 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694427007977 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694427007978 AIR carboxylase; Region: AIRC; pfam00731 694427007979 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 694427007980 lipoyl attachment site [posttranslational modification]; other site 694427007981 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 694427007982 putative catalytic site [active] 694427007983 putative metal binding site [ion binding]; other site 694427007984 putative phosphate binding site [ion binding]; other site 694427007985 Rhomboid family; Region: Rhomboid; pfam01694 694427007986 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 694427007987 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 694427007988 IHF - DNA interface [nucleotide binding]; other site 694427007989 IHF dimer interface [polypeptide binding]; other site 694427007990 DJ-1 family protein; Region: not_thiJ; TIGR01383 694427007991 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 694427007992 conserved cys residue [active] 694427007993 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 694427007994 active site 694427007995 hydrophilic channel; other site 694427007996 dimerization interface [polypeptide binding]; other site 694427007997 catalytic residues [active] 694427007998 active site lid [active] 694427007999 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 694427008000 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 694427008001 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 694427008002 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 694427008003 putative active site [active] 694427008004 substrate binding site [chemical binding]; other site 694427008005 putative cosubstrate binding site; other site 694427008006 catalytic site [active] 694427008007 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 694427008008 substrate binding site [chemical binding]; other site 694427008009 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 694427008010 homotrimer interaction site [polypeptide binding]; other site 694427008011 putative active site [active] 694427008012 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 694427008013 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427008014 active site 694427008015 HIGH motif; other site 694427008016 nucleotide binding site [chemical binding]; other site 694427008017 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 694427008018 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 694427008019 active site 694427008020 KMSKS motif; other site 694427008021 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 694427008022 tRNA binding surface [nucleotide binding]; other site 694427008023 anticodon binding site; other site 694427008024 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 694427008025 Transposase IS200 like; Region: Y1_Tnp; cl00848 694427008026 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 694427008027 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 694427008028 active site 694427008029 dimerization interface [polypeptide binding]; other site 694427008030 Uncharacterized protein containing a ferredoxin domain [Function unknown]; Region: COG4739 694427008031 Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; pfam09918 694427008032 geranylgeranylglyceryl phosphate synthase-like protein; Reviewed; Region: PRK04169 694427008033 PcrB family; Region: PcrB; pfam01884 694427008034 phosphate binding site [ion binding]; other site 694427008035 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 694427008036 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 694427008037 gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512 694427008038 Domain of unknown function DUF21; Region: DUF21; pfam01595 694427008039 gliding motility-associated protein GldE; Region: GldE; TIGR03520 694427008040 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 694427008041 Transporter associated domain; Region: CorC_HlyC; smart01091 694427008042 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 694427008043 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 694427008044 Ligand Binding Site [chemical binding]; other site 694427008045 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 694427008046 Ligand Binding Site [chemical binding]; other site 694427008047 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 694427008048 putative catalytic site [active] 694427008049 putative metal binding site [ion binding]; other site 694427008050 putative phosphate binding site [ion binding]; other site 694427008051 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 694427008052 Phosphate transporter family; Region: PHO4; pfam01384 694427008053 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 694427008054 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 694427008055 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 694427008056 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 694427008057 membrane protein insertase; Provisional; Region: PRK01318 694427008058 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 694427008059 CTP synthetase; Validated; Region: pyrG; PRK05380 694427008060 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 694427008061 Catalytic site [active] 694427008062 active site 694427008063 UTP binding site [chemical binding]; other site 694427008064 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 694427008065 active site 694427008066 putative oxyanion hole; other site 694427008067 catalytic triad [active] 694427008068 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694427008069 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 694427008070 active site 694427008071 nucleotide binding site [chemical binding]; other site 694427008072 HIGH motif; other site 694427008073 KMSKS motif; other site 694427008074 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 694427008075 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 694427008076 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 694427008077 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 694427008078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427008079 catalytic residue [active] 694427008080 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 694427008081 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 694427008082 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 694427008083 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 694427008084 Glutamine amidotransferase class-I; Region: GATase; pfam00117 694427008085 glutamine binding [chemical binding]; other site 694427008086 catalytic triad [active] 694427008087 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 694427008088 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 694427008089 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 694427008090 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 694427008091 active site 694427008092 ribulose/triose binding site [chemical binding]; other site 694427008093 phosphate binding site [ion binding]; other site 694427008094 substrate (anthranilate) binding pocket [chemical binding]; other site 694427008095 product (indole) binding pocket [chemical binding]; other site 694427008096 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 694427008097 active site 694427008098 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 694427008099 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 694427008100 substrate binding site [chemical binding]; other site 694427008101 active site 694427008102 catalytic residues [active] 694427008103 heterodimer interface [polypeptide binding]; other site 694427008104 translation initiation factor IF-2; Validated; Region: infB; PRK05306 694427008105 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 694427008106 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 694427008107 G1 box; other site 694427008108 putative GEF interaction site [polypeptide binding]; other site 694427008109 GTP/Mg2+ binding site [chemical binding]; other site 694427008110 Switch I region; other site 694427008111 G2 box; other site 694427008112 G3 box; other site 694427008113 Switch II region; other site 694427008114 G4 box; other site 694427008115 G5 box; other site 694427008116 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 694427008117 Translation-initiation factor 2; Region: IF-2; pfam11987 694427008118 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 694427008119 transcription termination factor NusA; Region: NusA; TIGR01953 694427008120 NusA N-terminal domain; Region: NusA_N; pfam08529 694427008121 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 694427008122 RNA binding site [nucleotide binding]; other site 694427008123 homodimer interface [polypeptide binding]; other site 694427008124 NusA-like KH domain; Region: KH_5; pfam13184 694427008125 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 694427008126 G-X-X-G motif; other site 694427008127 Sm and related proteins; Region: Sm_like; cl00259 694427008128 ribosome maturation protein RimP; Reviewed; Region: PRK00092 694427008129 heptamer interface [polypeptide binding]; other site 694427008130 Sm1 motif; other site 694427008131 hexamer interface [polypeptide binding]; other site 694427008132 RNA binding site [nucleotide binding]; other site 694427008133 Sm2 motif; other site 694427008134 butyrate kinase; Provisional; Region: PRK03011 694427008135 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 694427008136 exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178 694427008137 UGMP family protein; Validated; Region: PRK09604 694427008138 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 694427008139 Family of unknown function (DUF490); Region: DUF490; pfam04357 694427008140 Protein of unknown function (DUF3256); Region: DUF3256; pfam11644 694427008141 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 694427008142 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 694427008143 EamA-like transporter family; Region: EamA; cl17759 694427008144 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 694427008145 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 694427008146 dimerization interface 3.5A [polypeptide binding]; other site 694427008147 active site 694427008148 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 694427008149 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 694427008150 acyl-activating enzyme (AAE) consensus motif; other site 694427008151 putative AMP binding site [chemical binding]; other site 694427008152 putative active site [active] 694427008153 putative CoA binding site [chemical binding]; other site 694427008154 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 694427008155 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 694427008156 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 694427008157 putative active site [active] 694427008158 putative substrate binding site [chemical binding]; other site 694427008159 putative cosubstrate binding site; other site 694427008160 catalytic site [active] 694427008161 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 694427008162 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 694427008163 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427008164 ligand binding site [chemical binding]; other site 694427008165 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 694427008166 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 694427008167 Interdomain contacts; other site 694427008168 Cytokine receptor motif; other site 694427008169 Cadherin repeat-like domain; Region: CA_like; cl15786 694427008170 Ca2+ binding site [ion binding]; other site 694427008171 Bacterial Ig-like domain; Region: Big_5; pfam13205 694427008172 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 694427008173 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 694427008174 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 694427008175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694427008176 active site 694427008177 phosphorylation site [posttranslational modification] 694427008178 intermolecular recognition site; other site 694427008179 dimerization interface [polypeptide binding]; other site 694427008180 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 694427008181 DNA binding residues [nucleotide binding] 694427008182 dimerization interface [polypeptide binding]; other site 694427008183 PAS domain S-box; Region: sensory_box; TIGR00229 694427008184 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427008185 PAS fold; Region: PAS_3; pfam08447 694427008186 putative active site [active] 694427008187 heme pocket [chemical binding]; other site 694427008188 PAS domain S-box; Region: sensory_box; TIGR00229 694427008189 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 694427008190 putative active site [active] 694427008191 heme pocket [chemical binding]; other site 694427008192 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 694427008193 Histidine kinase; Region: HisKA_3; pfam07730 694427008194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694427008195 ATP binding site [chemical binding]; other site 694427008196 Mg2+ binding site [ion binding]; other site 694427008197 G-X-G motif; other site 694427008198 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 694427008199 Putative esterase; Region: Esterase; pfam00756 694427008200 N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858 694427008201 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 694427008202 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 694427008203 Glycosyl hydrolase family 43; Region: GH43_3; cd08982 694427008204 active site 694427008205 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 694427008206 sugar binding site [chemical binding]; other site 694427008207 Fibronectin type 3 domain; Region: FN3; smart00060 694427008208 Interdomain contacts; other site 694427008209 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 694427008210 PA14 domain; Region: PA14; cl08459 694427008211 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 694427008212 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 694427008213 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 694427008214 dimer interface [polypeptide binding]; other site 694427008215 ssDNA binding site [nucleotide binding]; other site 694427008216 tetramer (dimer of dimers) interface [polypeptide binding]; other site 694427008217 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 694427008218 L-aspartate oxidase; Provisional; Region: PRK09077 694427008219 L-aspartate oxidase; Provisional; Region: PRK06175 694427008220 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 694427008221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427008222 Coenzyme A binding pocket [chemical binding]; other site 694427008223 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 694427008224 active site 694427008225 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 694427008226 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 694427008227 NodB motif; other site 694427008228 putative active site [active] 694427008229 putative catalytic site [active] 694427008230 putative Zn binding site [ion binding]; other site 694427008231 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 694427008232 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 694427008233 DXD motif; other site 694427008234 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 694427008235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427008236 S-adenosylmethionine binding site [chemical binding]; other site 694427008237 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 694427008238 4Fe-4S binding domain; Region: Fer4_6; pfam12837 694427008239 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 694427008240 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 694427008241 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 694427008242 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 694427008243 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 694427008244 Cu(I) binding site [ion binding]; other site 694427008245 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 694427008246 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 694427008247 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 694427008248 Subunit I/III interface [polypeptide binding]; other site 694427008249 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 694427008250 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 694427008251 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 694427008252 Cytochrome c; Region: Cytochrom_C; pfam00034 694427008253 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 694427008254 UbiA prenyltransferase family; Region: UbiA; pfam01040 694427008255 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427008256 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 694427008257 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 694427008258 N-terminal plug; other site 694427008259 ligand-binding site [chemical binding]; other site 694427008260 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 694427008261 active site 694427008262 catalytic triad [active] 694427008263 oxyanion hole [active] 694427008264 Isochorismatase family; Region: Isochorismatase; pfam00857 694427008265 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 694427008266 catalytic triad [active] 694427008267 conserved cis-peptide bond; other site 694427008268 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 694427008269 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 694427008270 active site 694427008271 catalytic site [active] 694427008272 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 694427008273 TIGR03987 family protein; Region: TIGR03987 694427008274 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 694427008275 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 694427008276 active site 694427008277 DNA binding site [nucleotide binding] 694427008278 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 694427008279 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 694427008280 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 694427008281 Catalytic site [active] 694427008282 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 694427008283 active site 694427008284 Int/Topo IB signature motif; other site 694427008285 DNA binding site [nucleotide binding] 694427008286 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694427008287 Walker A motif; other site 694427008288 ATP binding site [chemical binding]; other site 694427008289 Walker B motif; other site 694427008290 arginine finger; other site 694427008291 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 694427008292 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 694427008293 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694427008294 ATP binding site [chemical binding]; other site 694427008295 putative Mg++ binding site [ion binding]; other site 694427008296 DltD central region; Region: DltD_M; pfam04918 694427008297 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 694427008298 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 694427008299 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 694427008300 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 694427008301 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 694427008302 HsdM N-terminal domain; Region: HsdM_N; pfam12161 694427008303 Methyltransferase domain; Region: Methyltransf_26; pfam13659 694427008304 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 694427008305 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 694427008306 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694427008307 ligand binding site [chemical binding]; other site 694427008308 Putative Ig domain; Region: He_PIG; pfam05345 694427008309 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 694427008310 Ca2+ binding site [ion binding]; other site 694427008311 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 694427008312 Ca2+ binding site [ion binding]; other site 694427008313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 694427008314 binding surface 694427008315 TPR motif; other site 694427008316 Helix-turn-helix domain; Region: HTH_18; pfam12833 694427008317 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694427008318 Predicted transcriptional regulators [Transcription]; Region: COG1733 694427008319 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 694427008320 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 694427008321 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 694427008322 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 694427008323 GDP-binding site [chemical binding]; other site 694427008324 ACT binding site; other site 694427008325 IMP binding site; other site 694427008326 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 694427008327 metal binding site 2 [ion binding]; metal-binding site 694427008328 putative DNA binding helix; other site 694427008329 metal binding site 1 [ion binding]; metal-binding site 694427008330 dimer interface [polypeptide binding]; other site 694427008331 structural Zn2+ binding site [ion binding]; other site 694427008332 A new structural DNA glycosylase; Region: AlkD_like; cd06561 694427008333 active site 694427008334 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 694427008335 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 694427008336 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 694427008337 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 694427008338 NodB motif; other site 694427008339 active site 694427008340 catalytic site [active] 694427008341 metal binding site [ion binding]; metal-binding site 694427008342 aspartate kinase III; Validated; Region: PRK09084 694427008343 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 694427008344 putative catalytic residues [active] 694427008345 nucleotide binding site [chemical binding]; other site 694427008346 aspartate binding site [chemical binding]; other site 694427008347 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 694427008348 dimer interface [polypeptide binding]; other site 694427008349 allosteric regulatory binding pocket; other site 694427008350 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 694427008351 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 694427008352 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 694427008353 active site 694427008354 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 694427008355 substrate binding site [chemical binding]; other site 694427008356 catalytic residues [active] 694427008357 dimer interface [polypeptide binding]; other site 694427008358 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 694427008359 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 694427008360 active site 694427008361 putative alpha-glucosidase; Provisional; Region: PRK10658 694427008362 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 694427008363 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 694427008364 trimer interface [polypeptide binding]; other site 694427008365 active site 694427008366 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 694427008367 catalytic site [active] 694427008368 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 694427008369 nucleotide binding site/active site [active] 694427008370 HIT family signature motif; other site 694427008371 catalytic residue [active] 694427008372 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 694427008373 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 694427008374 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 694427008375 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 694427008376 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 694427008377 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694427008378 FeS/SAM binding site; other site 694427008379 TRAM domain; Region: TRAM; pfam01938 694427008380 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 694427008381 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 694427008382 putative Iron-sulfur protein interface [polypeptide binding]; other site 694427008383 proximal heme binding site [chemical binding]; other site 694427008384 distal heme binding site [chemical binding]; other site 694427008385 putative dimer interface [polypeptide binding]; other site 694427008386 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 694427008387 L-aspartate oxidase; Provisional; Region: PRK06175 694427008388 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 694427008389 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 694427008390 four helix bundle protein; Region: TIGR02436 694427008391 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 694427008392 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 694427008393 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 694427008394 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 694427008395 trimer interface [polypeptide binding]; other site 694427008396 putative metal binding site [ion binding]; other site 694427008397 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 694427008398 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 694427008399 Walker A/P-loop; other site 694427008400 ATP binding site [chemical binding]; other site 694427008401 Q-loop/lid; other site 694427008402 ABC transporter signature motif; other site 694427008403 Walker B; other site 694427008404 D-loop; other site 694427008405 H-loop/switch region; other site 694427008406 MutS domain III; Region: MutS_III; pfam05192 694427008407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694427008408 Walker A/P-loop; other site 694427008409 ATP binding site [chemical binding]; other site 694427008410 Q-loop/lid; other site 694427008411 ABC transporter signature motif; other site 694427008412 Walker B; other site 694427008413 D-loop; other site 694427008414 H-loop/switch region; other site 694427008415 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694427008416 non-specific DNA binding site [nucleotide binding]; other site 694427008417 salt bridge; other site 694427008418 sequence-specific DNA binding site [nucleotide binding]; other site 694427008419 Domain of unknown function (DUF955); Region: DUF955; cl01076 694427008420 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 694427008421 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 694427008422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694427008423 Coenzyme A binding pocket [chemical binding]; other site 694427008424 Uncharacterized conserved protein [Function unknown]; Region: COG2128 694427008425 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 694427008426 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 694427008427 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 694427008428 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 694427008429 active site 694427008430 catalytic site [active] 694427008431 substrate binding site [chemical binding]; other site 694427008432 Uncharacterized conserved protein [Function unknown]; Region: COG4933 694427008433 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694427008434 non-specific DNA binding site [nucleotide binding]; other site 694427008435 salt bridge; other site 694427008436 sequence-specific DNA binding site [nucleotide binding]; other site 694427008437 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 694427008438 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 694427008439 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 694427008440 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 694427008441 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 694427008442 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 694427008443 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 694427008444 catalytic motif [active] 694427008445 Zn binding site [ion binding]; other site 694427008446 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 694427008447 C-terminal peptidase (prc); Region: prc; TIGR00225 694427008448 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 694427008449 protein binding site [polypeptide binding]; other site 694427008450 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 694427008451 Catalytic dyad [active] 694427008452 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 694427008453 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 694427008454 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 694427008455 active site 694427008456 catalytic site [active] 694427008457 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 694427008458 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 694427008459 carbohydrate-binding modules Eb and Fb from SusE and SusF, respectively, and similar CBMs; Region: CBM-Eb_CBM-Fb; cd12965 694427008460 starch binding site [chemical binding]; other site 694427008461 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 694427008462 starch binding site [chemical binding]; other site 694427008463 SusE outer membrane protein; Region: SusE; pfam14292 694427008464 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376 694427008465 starch binding site [chemical binding]; other site 694427008466 starch binding outer membrane protein SusD; Region: SusD; cd08977 694427008467 Cna protein B-type domain; Region: Cna_B_2; pfam13715 694427008468 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 694427008469 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 694427008470 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694427008471 Transcriptional regulators [Transcription]; Region: PurR; COG1609 694427008472 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 694427008473 DNA binding site [nucleotide binding] 694427008474 domain linker motif; other site 694427008475 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 694427008476 dimerization interface [polypeptide binding]; other site 694427008477 ligand binding site [chemical binding]; other site 694427008478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694427008479 Major Facilitator Superfamily; Region: MFS_1; pfam07690 694427008480 putative substrate translocation pore; other site 694427008481 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 694427008482 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 694427008483 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 694427008484 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 694427008485 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 694427008486 Ligand binding site; other site 694427008487 oligomer interface; other site 694427008488 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 694427008489 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 694427008490 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 694427008491 ligand binding site [chemical binding]; other site 694427008492 flexible hinge region; other site 694427008493 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 694427008494 non-specific DNA interactions [nucleotide binding]; other site 694427008495 DNA binding site [nucleotide binding] 694427008496 sequence specific DNA binding site [nucleotide binding]; other site 694427008497 putative cAMP binding site [chemical binding]; other site 694427008498 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427008499 TPR repeat; Region: TPR_11; pfam13414 694427008500 binding surface 694427008501 TPR motif; other site 694427008502 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694427008503 binding surface 694427008504 TPR motif; other site 694427008505 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 694427008506 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 694427008507 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 694427008508 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 694427008509 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 694427008510 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 694427008511 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 694427008512 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 694427008513 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 694427008514 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 694427008515 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 694427008516 NodB motif; other site 694427008517 active site 694427008518 catalytic site [active] 694427008519 metal binding site [ion binding]; metal-binding site 694427008520 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 694427008521 Bacterial Ig-like domain; Region: Big_5; pfam13205 694427008522 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 694427008523 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930 694427008524 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 694427008525 Methyltransferase domain; Region: Methyltransf_23; pfam13489 694427008526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694427008527 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 694427008528 active site 694427008529 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 694427008530 active site 694427008531 DNA polymerase IV; Validated; Region: PRK02406 694427008532 DNA binding site [nucleotide binding] 694427008533 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 694427008534 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 694427008535 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694427008536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694427008537 homodimer interface [polypeptide binding]; other site 694427008538 catalytic residue [active] 694427008539 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 694427008540 histidinol dehydrogenase; Region: hisD; TIGR00069 694427008541 NAD binding site [chemical binding]; other site 694427008542 dimerization interface [polypeptide binding]; other site 694427008543 product binding site; other site 694427008544 substrate binding site [chemical binding]; other site 694427008545 zinc binding site [ion binding]; other site 694427008546 catalytic residues [active] 694427008547 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 694427008548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694427008549 motif II; other site 694427008550 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 694427008551 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 694427008552 active site 694427008553 dimer interface [polypeptide binding]; other site 694427008554 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 694427008555 dimer interface [polypeptide binding]; other site 694427008556 active site 694427008557 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 694427008558 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 694427008559 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 694427008560 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 694427008561 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 694427008562 dimer interface [polypeptide binding]; other site 694427008563 putative anticodon binding site; other site 694427008564 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 694427008565 motif 1; other site 694427008566 active site 694427008567 motif 2; other site 694427008568 motif 3; other site 694427008569 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 694427008570 Phosphotransferase enzyme family; Region: APH; pfam01636 694427008571 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 694427008572 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 694427008573 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 694427008574 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 694427008575 Substrate binding site; other site 694427008576 metal-binding site 694427008577 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 694427008578 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 694427008579 Tetramer interface [polypeptide binding]; other site 694427008580 active site 694427008581 FMN-binding site [chemical binding]; other site 694427008582 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 694427008583 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 694427008584 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 694427008585 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 694427008586 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 694427008587 active site 694427008588 metal binding site [ion binding]; metal-binding site 694427008589 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 694427008590 mce related protein; Region: MCE; pfam02470