-- dump date 20140619_231024 -- class Genbank::misc_feature -- table misc_feature_note -- id note 592316000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 592316000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 592316000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316000004 Walker A motif; other site 592316000005 ATP binding site [chemical binding]; other site 592316000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 592316000007 Walker B motif; other site 592316000008 arginine finger; other site 592316000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 592316000010 DnaA box-binding interface [nucleotide binding]; other site 592316000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 592316000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 592316000013 putative DNA binding surface [nucleotide binding]; other site 592316000014 dimer interface [polypeptide binding]; other site 592316000015 beta-clamp/clamp loader binding surface; other site 592316000016 beta-clamp/translesion DNA polymerase binding surface; other site 592316000017 recF protein; Region: recf; TIGR00611 592316000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316000019 Walker A/P-loop; other site 592316000020 ATP binding site [chemical binding]; other site 592316000021 Q-loop/lid; other site 592316000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316000023 ABC transporter signature motif; other site 592316000024 Walker B; other site 592316000025 D-loop; other site 592316000026 H-loop/switch region; other site 592316000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 592316000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316000029 Mg2+ binding site [ion binding]; other site 592316000030 G-X-G motif; other site 592316000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 592316000032 anchoring element; other site 592316000033 dimer interface [polypeptide binding]; other site 592316000034 ATP binding site [chemical binding]; other site 592316000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 592316000036 active site 592316000037 putative metal-binding site [ion binding]; other site 592316000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 592316000039 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 592316000040 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 592316000041 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592316000042 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 592316000043 substrate binding site [chemical binding]; other site 592316000044 dimer interface [polypeptide binding]; other site 592316000045 ATP binding site [chemical binding]; other site 592316000046 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 592316000047 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 592316000048 inhibitor site; inhibition site 592316000049 active site 592316000050 dimer interface [polypeptide binding]; other site 592316000051 catalytic residue [active] 592316000052 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 592316000053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316000054 D-galactonate transporter; Region: 2A0114; TIGR00893 592316000055 putative substrate translocation pore; other site 592316000056 sugar phosphate phosphatase; Provisional; Region: PRK10513 592316000057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316000058 active site 592316000059 motif I; other site 592316000060 motif II; other site 592316000061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316000062 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 592316000063 hypothetical protein; Provisional; Region: PRK11616 592316000064 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 592316000065 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 592316000066 putative dimer interface [polypeptide binding]; other site 592316000067 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 592316000068 EamA-like transporter family; Region: EamA; pfam00892 592316000069 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 592316000070 putative deacylase active site [active] 592316000071 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 592316000072 active site 592316000073 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 592316000074 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 592316000075 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316000076 DNA-binding site [nucleotide binding]; DNA binding site 592316000077 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316000078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316000079 homodimer interface [polypeptide binding]; other site 592316000080 catalytic residue [active] 592316000081 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 592316000082 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316000083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316000084 homodimer interface [polypeptide binding]; other site 592316000085 catalytic residue [active] 592316000086 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 592316000087 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 592316000088 dimerization interface [polypeptide binding]; other site 592316000089 ligand binding site [chemical binding]; other site 592316000090 NADP binding site [chemical binding]; other site 592316000091 catalytic site [active] 592316000092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316000093 D-galactonate transporter; Region: 2A0114; TIGR00893 592316000094 putative substrate translocation pore; other site 592316000095 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592316000096 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 592316000097 substrate binding site [chemical binding]; other site 592316000098 ATP binding site [chemical binding]; other site 592316000099 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 592316000100 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592316000101 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316000102 DNA binding site [nucleotide binding] 592316000103 domain linker motif; other site 592316000104 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 592316000105 putative dimerization interface [polypeptide binding]; other site 592316000106 putative ligand binding site [chemical binding]; other site 592316000107 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592316000108 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316000109 DNA binding site [nucleotide binding] 592316000110 domain linker motif; other site 592316000111 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 592316000112 ligand binding site [chemical binding]; other site 592316000113 putative outer membrane lipoprotein; Provisional; Region: PRK10510 592316000114 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592316000115 ligand binding site [chemical binding]; other site 592316000116 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 592316000117 Autotransporter beta-domain; Region: Autotransporter; cl17461 592316000118 primosomal protein DnaI; Provisional; Region: PRK02854 592316000119 DNA replication protein DnaC; Validated; Region: PRK07952 592316000120 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316000121 Walker A motif; other site 592316000122 ATP binding site [chemical binding]; other site 592316000123 Walker B motif; other site 592316000124 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 592316000125 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 592316000126 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 592316000127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316000128 putative substrate translocation pore; other site 592316000129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316000130 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 592316000131 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316000132 DNA binding site [nucleotide binding] 592316000133 domain linker motif; other site 592316000134 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 592316000135 putative ligand binding site [chemical binding]; other site 592316000136 putative dimerization interface [polypeptide binding]; other site 592316000137 Acyltransferase family; Region: Acyl_transf_3; pfam01757 592316000138 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 592316000139 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592316000140 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 592316000141 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316000142 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316000143 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 592316000144 TIGR02646 family protein; Region: TIGR02646 592316000145 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 592316000146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316000147 Walker A/P-loop; other site 592316000148 ATP binding site [chemical binding]; other site 592316000149 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316000150 ABC transporter signature motif; other site 592316000151 Walker B; other site 592316000152 D-loop; other site 592316000153 H-loop/switch region; other site 592316000154 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 592316000155 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 592316000156 putative active site [active] 592316000157 putative NTP binding site [chemical binding]; other site 592316000158 putative nucleic acid binding site [nucleotide binding]; other site 592316000159 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592316000160 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316000161 non-specific DNA binding site [nucleotide binding]; other site 592316000162 salt bridge; other site 592316000163 sequence-specific DNA binding site [nucleotide binding]; other site 592316000164 Domain of unknown function (DUF955); Region: DUF955; cl01076 592316000165 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 592316000166 putative dimerization interface [polypeptide binding]; other site 592316000167 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592316000168 putative ligand binding site [chemical binding]; other site 592316000169 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316000170 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592316000171 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316000172 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316000173 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592316000174 TM-ABC transporter signature motif; other site 592316000175 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 592316000176 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 592316000177 Walker A/P-loop; other site 592316000178 ATP binding site [chemical binding]; other site 592316000179 Q-loop/lid; other site 592316000180 ABC transporter signature motif; other site 592316000181 Walker B; other site 592316000182 D-loop; other site 592316000183 H-loop/switch region; other site 592316000184 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 592316000185 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 592316000186 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 592316000187 putative ligand binding site [chemical binding]; other site 592316000188 xylose isomerase; Provisional; Region: PRK05474 592316000189 xylose isomerase; Region: xylose_isom_A; TIGR02630 592316000190 xylulokinase; Provisional; Region: PRK15027 592316000191 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 592316000192 N- and C-terminal domain interface [polypeptide binding]; other site 592316000193 active site 592316000194 MgATP binding site [chemical binding]; other site 592316000195 catalytic site [active] 592316000196 metal binding site [ion binding]; metal-binding site 592316000197 xylulose binding site [chemical binding]; other site 592316000198 homodimer interface [polypeptide binding]; other site 592316000199 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 592316000200 conserved cys residue [active] 592316000201 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316000202 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 592316000203 Acyltransferase family; Region: Acyl_transf_3; pfam01757 592316000204 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 592316000205 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 592316000206 active site pocket [active] 592316000207 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 592316000208 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316000209 DNA-binding site [nucleotide binding]; DNA binding site 592316000210 FCD domain; Region: FCD; pfam07729 592316000211 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 592316000212 allantoinase; Region: allantoinase; TIGR03178 592316000213 active site 592316000214 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 592316000215 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 592316000216 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 592316000217 active site 592316000218 substrate binding site [chemical binding]; other site 592316000219 FMN binding site [chemical binding]; other site 592316000220 putative catalytic residues [active] 592316000221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316000222 dimer interface [polypeptide binding]; other site 592316000223 conserved gate region; other site 592316000224 putative PBP binding loops; other site 592316000225 ABC-ATPase subunit interface; other site 592316000226 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316000227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316000228 Walker A/P-loop; other site 592316000229 ATP binding site [chemical binding]; other site 592316000230 Q-loop/lid; other site 592316000231 ABC transporter signature motif; other site 592316000232 Walker B; other site 592316000233 D-loop; other site 592316000234 H-loop/switch region; other site 592316000235 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 592316000236 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316000237 substrate binding pocket [chemical binding]; other site 592316000238 membrane-bound complex binding site; other site 592316000239 hinge residues; other site 592316000240 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 592316000241 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 592316000242 NAD binding site [chemical binding]; other site 592316000243 ligand binding site [chemical binding]; other site 592316000244 catalytic site [active] 592316000245 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 592316000246 homotrimer interaction site [polypeptide binding]; other site 592316000247 putative active site [active] 592316000248 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 592316000249 dimer interface [polypeptide binding]; other site 592316000250 motif 1; other site 592316000251 active site 592316000252 motif 2; other site 592316000253 motif 3; other site 592316000254 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 592316000255 DALR anticodon binding domain; Region: DALR_1; pfam05746 592316000256 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 592316000257 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 592316000258 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 592316000259 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 592316000260 G1 box; other site 592316000261 putative GEF interaction site [polypeptide binding]; other site 592316000262 GTP/Mg2+ binding site [chemical binding]; other site 592316000263 Switch I region; other site 592316000264 G2 box; other site 592316000265 G3 box; other site 592316000266 Switch II region; other site 592316000267 G4 box; other site 592316000268 G5 box; other site 592316000269 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 592316000270 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 592316000271 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 592316000272 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 592316000273 selenocysteine synthase; Provisional; Region: PRK04311 592316000274 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 592316000275 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 592316000276 putative glutathione S-transferase; Provisional; Region: PRK10357 592316000277 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 592316000278 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 592316000279 dimer interface [polypeptide binding]; other site 592316000280 N-terminal domain interface [polypeptide binding]; other site 592316000281 putative substrate binding pocket (H-site) [chemical binding]; other site 592316000282 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 592316000283 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 592316000284 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 592316000285 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 592316000286 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 592316000287 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 592316000288 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 592316000289 molybdopterin cofactor binding site; other site 592316000290 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 592316000291 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 592316000292 molybdopterin cofactor binding site; other site 592316000293 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 592316000294 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 592316000295 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 592316000296 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 592316000297 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 592316000298 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 592316000299 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592316000300 inhibitor-cofactor binding pocket; inhibition site 592316000301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316000302 catalytic residue [active] 592316000303 superoxide dismutase; Provisional; Region: PRK10925 592316000304 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 592316000305 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 592316000306 Protein of unknown function (DUF535); Region: DUF535; pfam04393 592316000307 hypothetical protein; Provisional; Region: PRK11020 592316000308 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 592316000309 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 592316000310 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 592316000311 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 592316000312 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 592316000313 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 592316000314 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 592316000315 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 592316000316 active site 592316000317 P-loop; other site 592316000318 phosphorylation site [posttranslational modification] 592316000319 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 592316000320 active site 592316000321 phosphorylation site [posttranslational modification] 592316000322 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 592316000323 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 592316000324 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 592316000325 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 592316000326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316000327 dimer interface [polypeptide binding]; other site 592316000328 conserved gate region; other site 592316000329 putative PBP binding loops; other site 592316000330 ABC-ATPase subunit interface; other site 592316000331 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316000332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316000333 dimer interface [polypeptide binding]; other site 592316000334 conserved gate region; other site 592316000335 ABC-ATPase subunit interface; other site 592316000336 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592316000337 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 592316000338 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 592316000339 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316000340 Walker A/P-loop; other site 592316000341 ATP binding site [chemical binding]; other site 592316000342 Q-loop/lid; other site 592316000343 ABC transporter signature motif; other site 592316000344 Walker B; other site 592316000345 D-loop; other site 592316000346 H-loop/switch region; other site 592316000347 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 592316000348 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 592316000349 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316000350 Walker A/P-loop; other site 592316000351 ATP binding site [chemical binding]; other site 592316000352 Q-loop/lid; other site 592316000353 ABC transporter signature motif; other site 592316000354 Walker B; other site 592316000355 D-loop; other site 592316000356 H-loop/switch region; other site 592316000357 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 592316000358 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316000359 Transcriptional regulators [Transcription]; Region: FadR; COG2186 592316000360 DNA-binding site [nucleotide binding]; DNA binding site 592316000361 FCD domain; Region: FCD; pfam07729 592316000362 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 592316000363 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 592316000364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316000365 putative PBP binding loops; other site 592316000366 ABC-ATPase subunit interface; other site 592316000367 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 592316000368 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 592316000369 Walker A/P-loop; other site 592316000370 ATP binding site [chemical binding]; other site 592316000371 Q-loop/lid; other site 592316000372 ABC transporter signature motif; other site 592316000373 Walker B; other site 592316000374 D-loop; other site 592316000375 H-loop/switch region; other site 592316000376 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 592316000377 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 592316000378 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 592316000379 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 592316000380 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592316000381 urea carboxylase; Region: urea_carbox; TIGR02712 592316000382 ATP-grasp domain; Region: ATP-grasp_4; cl17255 592316000383 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 592316000384 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 592316000385 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 592316000386 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 592316000387 carboxyltransferase (CT) interaction site; other site 592316000388 biotinylation site [posttranslational modification]; other site 592316000389 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316000390 non-specific DNA binding site [nucleotide binding]; other site 592316000391 salt bridge; other site 592316000392 sequence-specific DNA binding site [nucleotide binding]; other site 592316000393 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 592316000394 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592316000395 Zn2+ binding site [ion binding]; other site 592316000396 Mg2+ binding site [ion binding]; other site 592316000397 Transcriptional regulators [Transcription]; Region: MarR; COG1846 592316000398 MarR family; Region: MarR; pfam01047 592316000399 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 592316000400 phosphoethanolamine transferase; Provisional; Region: PRK11560 592316000401 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 592316000402 Sulfatase; Region: Sulfatase; pfam00884 592316000403 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592316000404 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 592316000405 peptide binding site [polypeptide binding]; other site 592316000406 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316000407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316000408 dimer interface [polypeptide binding]; other site 592316000409 conserved gate region; other site 592316000410 putative PBP binding loops; other site 592316000411 ABC-ATPase subunit interface; other site 592316000412 dipeptide transporter; Provisional; Region: PRK10913 592316000413 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 592316000414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316000415 dimer interface [polypeptide binding]; other site 592316000416 conserved gate region; other site 592316000417 putative PBP binding loops; other site 592316000418 ABC-ATPase subunit interface; other site 592316000419 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 592316000420 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316000421 Walker A/P-loop; other site 592316000422 ATP binding site [chemical binding]; other site 592316000423 Q-loop/lid; other site 592316000424 ABC transporter signature motif; other site 592316000425 Walker B; other site 592316000426 D-loop; other site 592316000427 H-loop/switch region; other site 592316000428 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316000429 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 592316000430 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316000431 Walker A/P-loop; other site 592316000432 ATP binding site [chemical binding]; other site 592316000433 Q-loop/lid; other site 592316000434 ABC transporter signature motif; other site 592316000435 Walker B; other site 592316000436 D-loop; other site 592316000437 H-loop/switch region; other site 592316000438 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 592316000439 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 592316000440 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 592316000441 P-loop; other site 592316000442 Magnesium ion binding site [ion binding]; other site 592316000443 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 592316000444 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 592316000445 DXD motif; other site 592316000446 PilZ domain; Region: PilZ; pfam07238 592316000447 cellulose synthase regulator protein; Provisional; Region: PRK11114 592316000448 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 592316000449 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592316000450 binding surface 592316000451 TPR motif; other site 592316000452 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 592316000453 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 592316000454 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 592316000455 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 592316000456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592316000457 TPR motif; other site 592316000458 binding surface 592316000459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592316000460 binding surface 592316000461 TPR motif; other site 592316000462 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 592316000463 cellulose synthase regulator protein; Provisional; Region: PRK11114 592316000464 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 592316000465 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 592316000466 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 592316000467 DXD motif; other site 592316000468 PilZ domain; Region: PilZ; pfam07238 592316000469 YhjQ protein; Region: YhjQ; pfam06564 592316000470 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 592316000471 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 592316000472 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 592316000473 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 592316000474 putative diguanylate cyclase; Provisional; Region: PRK13561 592316000475 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316000476 metal binding site [ion binding]; metal-binding site 592316000477 active site 592316000478 I-site; other site 592316000479 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592316000480 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 592316000481 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 592316000482 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 592316000483 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 592316000484 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 592316000485 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592316000486 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592316000487 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 592316000488 substrate binding site [chemical binding]; other site 592316000489 ATP binding site [chemical binding]; other site 592316000490 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592316000491 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 592316000492 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 592316000493 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 592316000494 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 592316000495 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 592316000496 Part of AAA domain; Region: AAA_19; pfam13245 592316000497 Family description; Region: UvrD_C_2; pfam13538 592316000498 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 592316000499 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 592316000500 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 592316000501 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 592316000502 ATP binding site [chemical binding]; other site 592316000503 Mg++ binding site [ion binding]; other site 592316000504 motif III; other site 592316000505 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592316000506 nucleotide binding region [chemical binding]; other site 592316000507 ATP-binding site [chemical binding]; other site 592316000508 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 592316000509 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 592316000510 catalytic residues [active] 592316000511 transcription termination factor Rho; Provisional; Region: rho; PRK09376 592316000512 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 592316000513 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 592316000514 RNA binding site [nucleotide binding]; other site 592316000515 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 592316000516 multimer interface [polypeptide binding]; other site 592316000517 Walker A motif; other site 592316000518 ATP binding site [chemical binding]; other site 592316000519 Walker B motif; other site 592316000520 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 592316000521 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 592316000522 Mg++ binding site [ion binding]; other site 592316000523 putative catalytic motif [active] 592316000524 substrate binding site [chemical binding]; other site 592316000525 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 592316000526 Chain length determinant protein; Region: Wzz; cl15801 592316000527 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 592316000528 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 592316000529 active site 592316000530 homodimer interface [polypeptide binding]; other site 592316000531 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 592316000532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 592316000533 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 592316000534 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 592316000535 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 592316000536 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316000537 Coenzyme A binding pocket [chemical binding]; other site 592316000538 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 592316000539 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 592316000540 inhibitor-cofactor binding pocket; inhibition site 592316000541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316000542 catalytic residue [active] 592316000543 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 592316000544 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929 592316000545 putative common antigen polymerase; Provisional; Region: PRK02975 592316000546 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 592316000547 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 592316000548 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 592316000549 HemY protein N-terminus; Region: HemY_N; pfam07219 592316000550 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 592316000551 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 592316000552 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 592316000553 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 592316000554 active site 592316000555 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 592316000556 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 592316000557 domain interfaces; other site 592316000558 active site 592316000559 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 592316000560 adenylate cyclase; Provisional; Region: cyaA; PRK09450 592316000561 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 592316000562 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 592316000563 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 592316000564 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 592316000565 hypothetical protein; Provisional; Region: PRK10963 592316000566 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 592316000567 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 592316000568 active site 592316000569 DNA binding site [nucleotide binding] 592316000570 Int/Topo IB signature motif; other site 592316000571 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 592316000572 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316000573 motif II; other site 592316000574 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 592316000575 Part of AAA domain; Region: AAA_19; pfam13245 592316000576 Family description; Region: UvrD_C_2; pfam13538 592316000577 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 592316000578 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 592316000579 Cl binding site [ion binding]; other site 592316000580 oligomer interface [polypeptide binding]; other site 592316000581 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 592316000582 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 592316000583 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 592316000584 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 592316000585 EamA-like transporter family; Region: EamA; cl17759 592316000586 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 592316000587 CoenzymeA binding site [chemical binding]; other site 592316000588 subunit interaction site [polypeptide binding]; other site 592316000589 PHB binding site; other site 592316000590 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 592316000591 dimerization interface [polypeptide binding]; other site 592316000592 substrate binding site [chemical binding]; other site 592316000593 active site 592316000594 calcium binding site [ion binding]; other site 592316000595 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 592316000596 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592316000597 ATP binding site [chemical binding]; other site 592316000598 putative Mg++ binding site [ion binding]; other site 592316000599 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592316000600 nucleotide binding region [chemical binding]; other site 592316000601 ATP-binding site [chemical binding]; other site 592316000602 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 592316000603 Helicase and RNase D C-terminal; Region: HRDC; smart00341 592316000604 threonine efflux system; Provisional; Region: PRK10229 592316000605 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 592316000606 lysophospholipase L2; Provisional; Region: PRK10749 592316000607 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 592316000608 putative hydrolase; Provisional; Region: PRK10976 592316000609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316000610 active site 592316000611 motif I; other site 592316000612 motif II; other site 592316000613 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316000614 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 592316000615 EamA-like transporter family; Region: EamA; pfam00892 592316000616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 592316000617 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 592316000618 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 592316000619 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 592316000620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316000621 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 592316000622 putative dimerization interface [polypeptide binding]; other site 592316000623 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 592316000624 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 592316000625 THF binding site; other site 592316000626 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 592316000627 substrate binding site [chemical binding]; other site 592316000628 THF binding site; other site 592316000629 zinc-binding site [ion binding]; other site 592316000630 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 592316000631 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 592316000632 uridine phosphorylase; Provisional; Region: PRK11178 592316000633 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 592316000634 RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]; Region: ROM1; COG5422 592316000635 DNA recombination protein RmuC; Provisional; Region: PRK10361 592316000636 RmuC family; Region: RmuC; pfam02646 592316000637 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 592316000638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316000639 S-adenosylmethionine binding site [chemical binding]; other site 592316000640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 592316000641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 592316000642 SCP-2 sterol transfer family; Region: SCP2; pfam02036 592316000643 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 592316000644 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 592316000645 twin arginine translocase protein A; Provisional; Region: tatA; PRK04598 592316000646 sec-independent translocase; Provisional; Region: PRK01770 592316000647 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 592316000648 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 592316000649 active site 592316000650 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 592316000651 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 592316000652 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 592316000653 active site pocket [active] 592316000654 oxyanion hole [active] 592316000655 catalytic triad [active] 592316000656 active site nucleophile [active] 592316000657 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 592316000658 FMN reductase; Validated; Region: fre; PRK08051 592316000659 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 592316000660 FAD binding pocket [chemical binding]; other site 592316000661 FAD binding motif [chemical binding]; other site 592316000662 phosphate binding motif [ion binding]; other site 592316000663 beta-alpha-beta structure motif; other site 592316000664 NAD binding pocket [chemical binding]; other site 592316000665 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 592316000666 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 592316000667 dimer interface [polypeptide binding]; other site 592316000668 active site 592316000669 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 592316000670 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 592316000671 substrate binding site [chemical binding]; other site 592316000672 oxyanion hole (OAH) forming residues; other site 592316000673 trimer interface [polypeptide binding]; other site 592316000674 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 592316000675 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 592316000676 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 592316000677 proline dipeptidase; Provisional; Region: PRK13607 592316000678 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 592316000679 active site 592316000680 hypothetical protein; Provisional; Region: PRK11568 592316000681 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 592316000682 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 592316000683 potassium transporter; Provisional; Region: PRK10750 592316000684 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 592316000685 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 592316000686 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 592316000687 FAD binding domain; Region: FAD_binding_4; pfam01565 592316000688 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 592316000689 Biotin operon repressor [Transcription]; Region: BirA; COG1654 592316000690 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 592316000691 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 592316000692 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 592316000693 pantothenate kinase; Provisional; Region: PRK05439 592316000694 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 592316000695 ATP-binding site [chemical binding]; other site 592316000696 CoA-binding site [chemical binding]; other site 592316000697 Mg2+-binding site [ion binding]; other site 592316000698 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 592316000699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316000700 Coenzyme A binding pocket [chemical binding]; other site 592316000701 elongation factor Tu; Reviewed; Region: PRK00049 592316000702 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 592316000703 G1 box; other site 592316000704 GEF interaction site [polypeptide binding]; other site 592316000705 GTP/Mg2+ binding site [chemical binding]; other site 592316000706 Switch I region; other site 592316000707 G2 box; other site 592316000708 G3 box; other site 592316000709 Switch II region; other site 592316000710 G4 box; other site 592316000711 G5 box; other site 592316000712 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 592316000713 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 592316000714 Antibiotic Binding Site [chemical binding]; other site 592316000715 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 592316000716 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 592316000717 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 592316000718 putative homodimer interface [polypeptide binding]; other site 592316000719 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 592316000720 heterodimer interface [polypeptide binding]; other site 592316000721 homodimer interface [polypeptide binding]; other site 592316000722 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 592316000723 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 592316000724 23S rRNA interface [nucleotide binding]; other site 592316000725 L7/L12 interface [polypeptide binding]; other site 592316000726 putative thiostrepton binding site; other site 592316000727 L25 interface [polypeptide binding]; other site 592316000728 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 592316000729 mRNA/rRNA interface [nucleotide binding]; other site 592316000730 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 592316000731 23S rRNA interface [nucleotide binding]; other site 592316000732 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 592316000733 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 592316000734 L11 interface [polypeptide binding]; other site 592316000735 putative EF-Tu interaction site [polypeptide binding]; other site 592316000736 putative EF-G interaction site [polypeptide binding]; other site 592316000737 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 592316000738 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 592316000739 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 592316000740 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 592316000741 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 592316000742 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 592316000743 RPB3 interaction site [polypeptide binding]; other site 592316000744 RPB1 interaction site [polypeptide binding]; other site 592316000745 RPB11 interaction site [polypeptide binding]; other site 592316000746 RPB10 interaction site [polypeptide binding]; other site 592316000747 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 592316000748 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 592316000749 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 592316000750 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 592316000751 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 592316000752 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 592316000753 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 592316000754 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 592316000755 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 592316000756 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 592316000757 DNA binding site [nucleotide binding] 592316000758 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 592316000759 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 592316000760 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 592316000761 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316000762 DNA-binding site [nucleotide binding]; DNA binding site 592316000763 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316000764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316000765 homodimer interface [polypeptide binding]; other site 592316000766 catalytic residue [active] 592316000767 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 592316000768 thiamine phosphate binding site [chemical binding]; other site 592316000769 active site 592316000770 pyrophosphate binding site [ion binding]; other site 592316000771 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 592316000772 ThiC-associated domain; Region: ThiC-associated; pfam13667 592316000773 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 592316000774 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 592316000775 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 592316000776 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 592316000777 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 592316000778 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 592316000779 putative NADH binding site [chemical binding]; other site 592316000780 putative active site [active] 592316000781 nudix motif; other site 592316000782 putative metal binding site [ion binding]; other site 592316000783 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 592316000784 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 592316000785 substrate binding site [chemical binding]; other site 592316000786 active site 592316000787 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 592316000788 Active_site [active] 592316000789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 592316000790 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 592316000791 IHF dimer interface [polypeptide binding]; other site 592316000792 IHF - DNA interface [nucleotide binding]; other site 592316000793 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 592316000794 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 592316000795 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 592316000796 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 592316000797 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 592316000798 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 592316000799 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 592316000800 purine monophosphate binding site [chemical binding]; other site 592316000801 dimer interface [polypeptide binding]; other site 592316000802 putative catalytic residues [active] 592316000803 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 592316000804 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 592316000805 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 592316000806 homoserine O-succinyltransferase; Provisional; Region: PRK05368 592316000807 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 592316000808 proposed active site lysine [active] 592316000809 conserved cys residue [active] 592316000810 malate synthase A; Region: malate_syn_A; TIGR01344 592316000811 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 592316000812 active site 592316000813 isocitrate lyase; Provisional; Region: PRK15063 592316000814 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 592316000815 tetramer interface [polypeptide binding]; other site 592316000816 active site 592316000817 Mg2+/Mn2+ binding site [ion binding]; other site 592316000818 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 592316000819 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 592316000820 transcriptional repressor IclR; Provisional; Region: PRK11569 592316000821 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 592316000822 Bacterial transcriptional regulator; Region: IclR; pfam01614 592316000823 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 592316000824 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 592316000825 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 592316000826 substrate binding pocket [chemical binding]; other site 592316000827 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 592316000828 B12 binding site [chemical binding]; other site 592316000829 cobalt ligand [ion binding]; other site 592316000830 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 592316000831 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 592316000832 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 592316000833 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 592316000834 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 592316000835 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 592316000836 active site 592316000837 dimer interface [polypeptide binding]; other site 592316000838 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 592316000839 dimer interface [polypeptide binding]; other site 592316000840 active site 592316000841 aspartate kinase III; Validated; Region: PRK09084 592316000842 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 592316000843 nucleotide binding site [chemical binding]; other site 592316000844 putative catalytic residues [active] 592316000845 aspartate binding site [chemical binding]; other site 592316000846 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 592316000847 lysine allosteric regulatory site; other site 592316000848 dimer interface [polypeptide binding]; other site 592316000849 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 592316000850 dimer interface [polypeptide binding]; other site 592316000851 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 592316000852 amphipathic channel; other site 592316000853 Asn-Pro-Ala signature motifs; other site 592316000854 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 592316000855 Sodium Bile acid symporter family; Region: SBF; pfam01758 592316000856 putative antibiotic transporter; Provisional; Region: PRK10739 592316000857 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 592316000858 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 592316000859 glycogen branching enzyme; Provisional; Region: PRK05402 592316000860 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 592316000861 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 592316000862 active site 592316000863 catalytic site [active] 592316000864 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 592316000865 glycogen debranching enzyme; Provisional; Region: PRK03705 592316000866 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 592316000867 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 592316000868 active site 592316000869 catalytic site [active] 592316000870 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 592316000871 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 592316000872 ligand binding site; other site 592316000873 oligomer interface; other site 592316000874 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 592316000875 dimer interface [polypeptide binding]; other site 592316000876 N-terminal domain interface [polypeptide binding]; other site 592316000877 sulfate 1 binding site; other site 592316000878 glycogen synthase; Provisional; Region: glgA; PRK00654 592316000879 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 592316000880 ADP-binding pocket [chemical binding]; other site 592316000881 homodimer interface [polypeptide binding]; other site 592316000882 glycogen phosphorylase; Provisional; Region: PRK14986 592316000883 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 592316000884 homodimer interface [polypeptide binding]; other site 592316000885 active site pocket [active] 592316000886 hypothetical protein; Provisional; Region: PRK11615 592316000887 hypothetical protein; Provisional; Region: PRK11212 592316000888 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 592316000889 CPxP motif; other site 592316000890 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 592316000891 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 592316000892 metal-binding site [ion binding] 592316000893 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 592316000894 Predicted membrane protein [Function unknown]; Region: COG3714 592316000895 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 592316000896 hypothetical protein; Provisional; Region: PRK10910 592316000897 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 592316000898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316000899 S-adenosylmethionine binding site [chemical binding]; other site 592316000900 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 592316000901 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 592316000902 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 592316000903 P loop; other site 592316000904 GTP binding site [chemical binding]; other site 592316000905 cell division protein FtsE; Provisional; Region: PRK10908 592316000906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316000907 Walker A/P-loop; other site 592316000908 ATP binding site [chemical binding]; other site 592316000909 Q-loop/lid; other site 592316000910 ABC transporter signature motif; other site 592316000911 Walker B; other site 592316000912 D-loop; other site 592316000913 H-loop/switch region; other site 592316000914 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 592316000915 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 592316000916 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 592316000917 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592316000918 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592316000919 DNA binding residues [nucleotide binding] 592316000920 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 592316000921 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 592316000922 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 592316000923 dimerization interface [polypeptide binding]; other site 592316000924 ligand binding site [chemical binding]; other site 592316000925 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316000926 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 592316000927 TM-ABC transporter signature motif; other site 592316000928 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 592316000929 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 592316000930 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 592316000931 TM-ABC transporter signature motif; other site 592316000932 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 592316000933 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 592316000934 Walker A/P-loop; other site 592316000935 ATP binding site [chemical binding]; other site 592316000936 Q-loop/lid; other site 592316000937 ABC transporter signature motif; other site 592316000938 Walker B; other site 592316000939 D-loop; other site 592316000940 H-loop/switch region; other site 592316000941 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 592316000942 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 592316000943 Walker A/P-loop; other site 592316000944 ATP binding site [chemical binding]; other site 592316000945 Q-loop/lid; other site 592316000946 ABC transporter signature motif; other site 592316000947 Walker B; other site 592316000948 D-loop; other site 592316000949 H-loop/switch region; other site 592316000950 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 592316000951 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 592316000952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316000953 putative PBP binding loops; other site 592316000954 dimer interface [polypeptide binding]; other site 592316000955 ABC-ATPase subunit interface; other site 592316000956 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 592316000957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316000958 dimer interface [polypeptide binding]; other site 592316000959 conserved gate region; other site 592316000960 putative PBP binding loops; other site 592316000961 ABC-ATPase subunit interface; other site 592316000962 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 592316000963 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 592316000964 Walker A/P-loop; other site 592316000965 ATP binding site [chemical binding]; other site 592316000966 Q-loop/lid; other site 592316000967 ABC transporter signature motif; other site 592316000968 Walker B; other site 592316000969 D-loop; other site 592316000970 H-loop/switch region; other site 592316000971 TOBE domain; Region: TOBE_2; pfam08402 592316000972 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 592316000973 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 592316000974 putative active site [active] 592316000975 catalytic site [active] 592316000976 putative metal binding site [ion binding]; other site 592316000977 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 592316000978 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 592316000979 putative acetyltransferase YhhY; Provisional; Region: PRK10140 592316000980 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316000981 Coenzyme A binding pocket [chemical binding]; other site 592316000982 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 592316000983 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316000984 DNA binding site [nucleotide binding] 592316000985 domain linker motif; other site 592316000986 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 592316000987 putative ligand binding site [chemical binding]; other site 592316000988 putative dimerization interface [polypeptide binding]; other site 592316000989 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 592316000990 ATP-binding site [chemical binding]; other site 592316000991 Gluconate-6-phosphate binding site [chemical binding]; other site 592316000992 Shikimate kinase; Region: SKI; pfam01202 592316000993 low affinity gluconate transporter; Provisional; Region: PRK10472 592316000994 gluconate transporter; Region: gntP; TIGR00791 592316000995 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 592316000996 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 592316000997 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 592316000998 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 592316000999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316001000 Walker A/P-loop; other site 592316001001 ATP binding site [chemical binding]; other site 592316001002 Q-loop/lid; other site 592316001003 ABC transporter signature motif; other site 592316001004 Walker B; other site 592316001005 D-loop; other site 592316001006 H-loop/switch region; other site 592316001007 TOBE domain; Region: TOBE_2; pfam08402 592316001008 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 592316001009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316001010 dimer interface [polypeptide binding]; other site 592316001011 conserved gate region; other site 592316001012 putative PBP binding loops; other site 592316001013 ABC-ATPase subunit interface; other site 592316001014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316001015 dimer interface [polypeptide binding]; other site 592316001016 conserved gate region; other site 592316001017 putative PBP binding loops; other site 592316001018 ABC-ATPase subunit interface; other site 592316001019 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 592316001020 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 592316001021 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 592316001022 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316001023 DNA-binding site [nucleotide binding]; DNA binding site 592316001024 transcriptional regulator protein; Region: phnR; TIGR03337 592316001025 UTRA domain; Region: UTRA; pfam07702 592316001026 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 592316001027 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 592316001028 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592316001029 Chorismate lyase; Region: Chor_lyase; cl01230 592316001030 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 592316001031 UbiA prenyltransferase family; Region: UbiA; pfam01040 592316001032 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 592316001033 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 592316001034 putative acyl-acceptor binding pocket; other site 592316001035 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 592316001036 LexA repressor; Validated; Region: PRK00215 592316001037 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 592316001038 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 592316001039 Catalytic site [active] 592316001040 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 592316001041 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 592316001042 hypothetical protein; Provisional; Region: PRK10428 592316001043 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 592316001044 metal binding site 2 [ion binding]; metal-binding site 592316001045 putative DNA binding helix; other site 592316001046 metal binding site 1 [ion binding]; metal-binding site 592316001047 dimer interface [polypeptide binding]; other site 592316001048 structural Zn2+ binding site [ion binding]; other site 592316001049 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 592316001050 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 592316001051 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 592316001052 FMN binding site [chemical binding]; other site 592316001053 active site 592316001054 catalytic residues [active] 592316001055 substrate binding site [chemical binding]; other site 592316001056 phage shock protein G; Reviewed; Region: pspG; PRK09459 592316001057 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 592316001058 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 592316001059 NADP binding site [chemical binding]; other site 592316001060 dimer interface [polypeptide binding]; other site 592316001061 replicative DNA helicase; Provisional; Region: PRK08006 592316001062 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 592316001063 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 592316001064 Walker A motif; other site 592316001065 ATP binding site [chemical binding]; other site 592316001066 Walker B motif; other site 592316001067 DNA binding loops [nucleotide binding] 592316001068 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 592316001069 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 592316001070 putative DNA binding site [nucleotide binding]; other site 592316001071 putative Zn2+ binding site [ion binding]; other site 592316001072 Uncharacterized conserved protein [Function unknown]; Region: COG1284 592316001073 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 592316001074 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 592316001075 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 592316001076 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316001077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316001078 homodimer interface [polypeptide binding]; other site 592316001079 catalytic residue [active] 592316001080 Uncharacterized conserved protein [Function unknown]; Region: COG0432 592316001081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 592316001082 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 592316001083 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 592316001084 putative NAD(P) binding site [chemical binding]; other site 592316001085 putative substrate binding site [chemical binding]; other site 592316001086 catalytic Zn binding site [ion binding]; other site 592316001087 structural Zn binding site [ion binding]; other site 592316001088 dimer interface [polypeptide binding]; other site 592316001089 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 592316001090 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 592316001091 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 592316001092 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 592316001093 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 592316001094 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 592316001095 dimer interface [polypeptide binding]; other site 592316001096 ssDNA binding site [nucleotide binding]; other site 592316001097 tetramer (dimer of dimers) interface [polypeptide binding]; other site 592316001098 aromatic amino acid transporter; Provisional; Region: PRK10238 592316001099 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 592316001100 Isochorismatase family; Region: Isochorismatase; pfam00857 592316001101 catalytic triad [active] 592316001102 conserved cis-peptide bond; other site 592316001103 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 592316001104 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316001105 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592316001106 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 592316001107 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 592316001108 DNA-binding interface [nucleotide binding]; DNA binding site 592316001109 Winged helix-turn helix; Region: HTH_29; pfam13551 592316001110 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 592316001111 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 592316001112 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 592316001113 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 592316001114 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316001115 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 592316001116 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 592316001117 DNA binding residues [nucleotide binding] 592316001118 dimer interface [polypeptide binding]; other site 592316001119 [2Fe-2S] cluster binding site [ion binding]; other site 592316001120 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 592316001121 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 592316001122 putative C-terminal domain interface [polypeptide binding]; other site 592316001123 putative GSH binding site (G-site) [chemical binding]; other site 592316001124 putative dimer interface [polypeptide binding]; other site 592316001125 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 592316001126 putative dimer interface [polypeptide binding]; other site 592316001127 putative N-terminal domain interface [polypeptide binding]; other site 592316001128 putative substrate binding pocket (H-site) [chemical binding]; other site 592316001129 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 592316001130 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 592316001131 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 592316001132 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316001133 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316001134 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 592316001135 putative dimerization interface [polypeptide binding]; other site 592316001136 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 592316001137 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 592316001138 YfaZ precursor; Region: YfaZ; pfam07437 592316001139 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 592316001140 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 592316001141 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 592316001142 Na binding site [ion binding]; other site 592316001143 Predicted membrane protein [Function unknown]; Region: COG3162 592316001144 acetyl-CoA synthetase; Provisional; Region: PRK00174 592316001145 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 592316001146 active site 592316001147 CoA binding site [chemical binding]; other site 592316001148 acyl-activating enzyme (AAE) consensus motif; other site 592316001149 AMP binding site [chemical binding]; other site 592316001150 acetate binding site [chemical binding]; other site 592316001151 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 592316001152 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 592316001153 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 592316001154 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 592316001155 putative active site [active] 592316001156 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 592316001157 trimer interface [polypeptide binding]; other site 592316001158 active site 592316001159 substrate binding site [chemical binding]; other site 592316001160 CoA binding site [chemical binding]; other site 592316001161 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 592316001162 active site 592316001163 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592316001164 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 592316001165 colanic acid biosynthesis glycosyl transferase WcaA; Region: WcaA; TIGR04017 592316001166 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592316001167 active site 592316001168 tyrosine kinase; Provisional; Region: PRK11519 592316001169 Chain length determinant protein; Region: Wzz; pfam02706 592316001170 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 592316001171 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 592316001172 P loop; other site 592316001173 Nucleotide binding site [chemical binding]; other site 592316001174 DTAP/Switch II; other site 592316001175 Switch I; other site 592316001176 tyrosine kinase; Provisional; Region: PRK11519 592316001177 Chain length determinant protein; Region: Wzz; pfam02706 592316001178 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 592316001179 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 592316001180 Nucleotide binding site [chemical binding]; other site 592316001181 DTAP/Switch II; other site 592316001182 Switch I; other site 592316001183 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592316001184 PAS domain; Region: PAS_9; pfam13426 592316001185 putative active site [active] 592316001186 heme pocket [chemical binding]; other site 592316001187 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 592316001188 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592316001189 dimer interface [polypeptide binding]; other site 592316001190 putative CheW interface [polypeptide binding]; other site 592316001191 Cupin; Region: Cupin_6; pfam12852 592316001192 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316001193 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592316001194 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316001195 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 592316001196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316001197 putative substrate translocation pore; other site 592316001198 PQQ-like domain; Region: PQQ_2; pfam13360 592316001199 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 592316001200 microcin B17 transporter; Reviewed; Region: PRK11098 592316001201 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 592316001202 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 592316001203 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 592316001204 Cytochrome c; Region: Cytochrom_C; pfam00034 592316001205 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316001206 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316001207 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 592316001208 benzoate transport; Region: 2A0115; TIGR00895 592316001209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316001210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316001211 putative substrate translocation pore; other site 592316001212 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 592316001213 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 592316001214 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 592316001215 amidohydrolase; Region: amidohydrolases; TIGR01891 592316001216 putative metal binding site [ion binding]; other site 592316001217 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 592316001218 amidohydrolase; Region: amidohydrolases; TIGR01891 592316001219 putative metal binding site [ion binding]; other site 592316001220 dimer interface [polypeptide binding]; other site 592316001221 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 592316001222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316001223 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316001224 dimerization interface [polypeptide binding]; other site 592316001225 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592316001226 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 592316001227 dimer interface [polypeptide binding]; other site 592316001228 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 592316001229 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 592316001230 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316001231 dimer interface [polypeptide binding]; other site 592316001232 phosphorylation site [posttranslational modification] 592316001233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316001234 ATP binding site [chemical binding]; other site 592316001235 Mg2+ binding site [ion binding]; other site 592316001236 G-X-G motif; other site 592316001237 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 592316001238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316001239 active site 592316001240 phosphorylation site [posttranslational modification] 592316001241 intermolecular recognition site; other site 592316001242 dimerization interface [polypeptide binding]; other site 592316001243 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592316001244 DNA binding site [nucleotide binding] 592316001245 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 592316001246 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316001247 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316001248 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316001249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316001250 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 592316001251 putative effector binding pocket; other site 592316001252 dimerization interface [polypeptide binding]; other site 592316001253 drug efflux system protein MdtG; Provisional; Region: PRK09874 592316001254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316001255 putative substrate translocation pore; other site 592316001256 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 592316001257 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 592316001258 Trp docking motif [polypeptide binding]; other site 592316001259 putative active site [active] 592316001260 enterobactin exporter EntS; Provisional; Region: PRK10489 592316001261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316001262 putative substrate translocation pore; other site 592316001263 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592316001264 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592316001265 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592316001266 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 592316001267 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 592316001268 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 592316001269 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 592316001270 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 592316001271 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 592316001272 Walker A/P-loop; other site 592316001273 ATP binding site [chemical binding]; other site 592316001274 Q-loop/lid; other site 592316001275 ABC transporter signature motif; other site 592316001276 Walker B; other site 592316001277 D-loop; other site 592316001278 H-loop/switch region; other site 592316001279 TOBE domain; Region: TOBE_2; pfam08402 592316001280 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 592316001281 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 592316001282 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 592316001283 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 592316001284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316001285 dimer interface [polypeptide binding]; other site 592316001286 conserved gate region; other site 592316001287 putative PBP binding loops; other site 592316001288 ABC-ATPase subunit interface; other site 592316001289 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 592316001290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316001291 dimer interface [polypeptide binding]; other site 592316001292 conserved gate region; other site 592316001293 putative PBP binding loops; other site 592316001294 ABC-ATPase subunit interface; other site 592316001295 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 592316001296 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 592316001297 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 592316001298 tartrate dehydrogenase; Region: TTC; TIGR02089 592316001299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316001300 transcriptional activator TtdR; Provisional; Region: PRK09801 592316001301 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316001302 dimerization interface [polypeptide binding]; other site 592316001303 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 592316001304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316001305 putative substrate translocation pore; other site 592316001306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316001307 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 592316001308 putative transporter; Provisional; Region: PRK10484 592316001309 Na binding site [ion binding]; other site 592316001310 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 592316001311 BNR repeat-like domain; Region: BNR_2; pfam13088 592316001312 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 592316001313 classical (c) SDRs; Region: SDR_c; cd05233 592316001314 NAD(P) binding site [chemical binding]; other site 592316001315 active site 592316001316 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 592316001317 Bacterial transcriptional regulator; Region: IclR; pfam01614 592316001318 PAS domain; Region: PAS; smart00091 592316001319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316001320 Walker A motif; other site 592316001321 ATP binding site [chemical binding]; other site 592316001322 Walker B motif; other site 592316001323 arginine finger; other site 592316001324 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 592316001325 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592316001326 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592316001327 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592316001328 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 592316001329 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 592316001330 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 592316001331 putative ligand binding site [chemical binding]; other site 592316001332 PQQ-like domain; Region: PQQ_2; pfam13360 592316001333 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 592316001334 structural tetrad; other site 592316001335 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 592316001336 putative S-transferase; Provisional; Region: PRK11752 592316001337 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 592316001338 C-terminal domain interface [polypeptide binding]; other site 592316001339 GSH binding site (G-site) [chemical binding]; other site 592316001340 dimer interface [polypeptide binding]; other site 592316001341 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 592316001342 dimer interface [polypeptide binding]; other site 592316001343 N-terminal domain interface [polypeptide binding]; other site 592316001344 active site 592316001345 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316001346 DNA binding site [nucleotide binding] 592316001347 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 592316001348 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 592316001349 putative ligand binding site [chemical binding]; other site 592316001350 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592316001351 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592316001352 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592316001353 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 592316001354 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592316001355 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592316001356 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316001357 DNA binding site [nucleotide binding] 592316001358 domain linker motif; other site 592316001359 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 592316001360 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 592316001361 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 592316001362 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592316001363 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592316001364 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592316001365 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316001366 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316001367 Walker A/P-loop; other site 592316001368 ATP binding site [chemical binding]; other site 592316001369 Q-loop/lid; other site 592316001370 ABC transporter signature motif; other site 592316001371 Walker B; other site 592316001372 D-loop; other site 592316001373 H-loop/switch region; other site 592316001374 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316001375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316001376 dimer interface [polypeptide binding]; other site 592316001377 conserved gate region; other site 592316001378 putative PBP binding loops; other site 592316001379 ABC-ATPase subunit interface; other site 592316001380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316001381 dimer interface [polypeptide binding]; other site 592316001382 conserved gate region; other site 592316001383 putative PBP binding loops; other site 592316001384 ABC-ATPase subunit interface; other site 592316001385 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 592316001386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316001387 NAD(P) binding site [chemical binding]; other site 592316001388 active site 592316001389 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 592316001390 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 592316001391 carboxyltransferase (CT) interaction site; other site 592316001392 biotinylation site [posttranslational modification]; other site 592316001393 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 592316001394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316001395 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 592316001396 putative dimerization interface [polypeptide binding]; other site 592316001397 aspartate aminotransferase; Provisional; Region: PRK05764 592316001398 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316001399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316001400 homodimer interface [polypeptide binding]; other site 592316001401 catalytic residue [active] 592316001402 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 592316001403 putative active site [active] 592316001404 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 592316001405 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 592316001406 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 592316001407 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316001408 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316001409 substrate binding pocket [chemical binding]; other site 592316001410 membrane-bound complex binding site; other site 592316001411 hinge residues; other site 592316001412 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 592316001413 EamA-like transporter family; Region: EamA; pfam00892 592316001414 hypothetical protein; Validated; Region: PRK06201 592316001415 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 592316001416 putative sialic acid transporter; Provisional; Region: PRK03893 592316001417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316001418 putative substrate translocation pore; other site 592316001419 transcriptional antiterminator BglG; Provisional; Region: PRK09772 592316001420 CAT RNA binding domain; Region: CAT_RBD; smart01061 592316001421 PRD domain; Region: PRD; pfam00874 592316001422 PRD domain; Region: PRD; pfam00874 592316001423 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 592316001424 beta-galactosidase; Region: BGL; TIGR03356 592316001425 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 592316001426 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 592316001427 active site turn [active] 592316001428 phosphorylation site [posttranslational modification] 592316001429 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 592316001430 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 592316001431 HPr interaction site; other site 592316001432 glycerol kinase (GK) interaction site [polypeptide binding]; other site 592316001433 active site 592316001434 phosphorylation site [posttranslational modification] 592316001435 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316001436 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316001437 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316001438 dimerization interface [polypeptide binding]; other site 592316001439 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 592316001440 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 592316001441 FMN-binding pocket [chemical binding]; other site 592316001442 flavin binding motif; other site 592316001443 phosphate binding motif [ion binding]; other site 592316001444 beta-alpha-beta structure motif; other site 592316001445 NAD binding pocket [chemical binding]; other site 592316001446 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 592316001447 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 592316001448 catalytic loop [active] 592316001449 iron binding site [ion binding]; other site 592316001450 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 592316001451 Amidohydrolase; Region: Amidohydro_4; pfam13147 592316001452 active site 592316001453 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 592316001454 homotrimer interaction site [polypeptide binding]; other site 592316001455 putative active site [active] 592316001456 Creatinine amidohydrolase; Region: Creatininase; pfam02633 592316001457 NMT1/THI5 like; Region: NMT1; pfam09084 592316001458 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 592316001459 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 592316001460 Walker A/P-loop; other site 592316001461 ATP binding site [chemical binding]; other site 592316001462 Q-loop/lid; other site 592316001463 ABC transporter signature motif; other site 592316001464 Walker B; other site 592316001465 D-loop; other site 592316001466 H-loop/switch region; other site 592316001467 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 592316001468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316001469 dimer interface [polypeptide binding]; other site 592316001470 conserved gate region; other site 592316001471 putative PBP binding loops; other site 592316001472 ABC-ATPase subunit interface; other site 592316001473 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 592316001474 FAD binding domain; Region: FAD_binding_4; pfam01565 592316001475 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 592316001476 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 592316001477 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 592316001478 active site 592316001479 homotetramer interface [polypeptide binding]; other site 592316001480 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 592316001481 potassium uptake protein; Region: kup; TIGR00794 592316001482 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 592316001483 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 592316001484 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 592316001485 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 592316001486 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 592316001487 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592316001488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316001489 Walker A/P-loop; other site 592316001490 ATP binding site [chemical binding]; other site 592316001491 Q-loop/lid; other site 592316001492 ABC transporter signature motif; other site 592316001493 Walker B; other site 592316001494 D-loop; other site 592316001495 H-loop/switch region; other site 592316001496 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 592316001497 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 592316001498 Walker A/P-loop; other site 592316001499 ATP binding site [chemical binding]; other site 592316001500 Q-loop/lid; other site 592316001501 ABC transporter signature motif; other site 592316001502 Walker B; other site 592316001503 D-loop; other site 592316001504 H-loop/switch region; other site 592316001505 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 592316001506 putative transcriptional regulator; Provisional; Region: PRK11640 592316001507 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316001508 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 592316001509 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 592316001510 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 592316001511 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 592316001512 DsbD alpha interface [polypeptide binding]; other site 592316001513 catalytic residues [active] 592316001514 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 592316001515 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 592316001516 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 592316001517 Aspartase; Region: Aspartase; cd01357 592316001518 active sites [active] 592316001519 tetramer interface [polypeptide binding]; other site 592316001520 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 592316001521 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 592316001522 oligomerisation interface [polypeptide binding]; other site 592316001523 mobile loop; other site 592316001524 roof hairpin; other site 592316001525 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 592316001526 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 592316001527 ring oligomerisation interface [polypeptide binding]; other site 592316001528 ATP/Mg binding site [chemical binding]; other site 592316001529 stacking interactions; other site 592316001530 hinge regions; other site 592316001531 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 592316001532 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 592316001533 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592316001534 FeS/SAM binding site; other site 592316001535 elongation factor P; Validated; Region: PRK00529 592316001536 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 592316001537 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 592316001538 RNA binding site [nucleotide binding]; other site 592316001539 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 592316001540 RNA binding site [nucleotide binding]; other site 592316001541 Entericidin EcnA/B family; Region: Entericidin; pfam08085 592316001542 Predicted small secreted protein [Function unknown]; Region: COG5510 592316001543 poxB regulator PoxA; Provisional; Region: PRK09350 592316001544 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 592316001545 motif 1; other site 592316001546 dimer interface [polypeptide binding]; other site 592316001547 active site 592316001548 motif 2; other site 592316001549 motif 3; other site 592316001550 serine endoprotease; Provisional; Region: PRK10898 592316001551 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 592316001552 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 592316001553 protein binding site [polypeptide binding]; other site 592316001554 serine endoprotease; Provisional; Region: PRK10139 592316001555 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 592316001556 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 592316001557 protein binding site [polypeptide binding]; other site 592316001558 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 592316001559 protein binding site [polypeptide binding]; other site 592316001560 hypothetical protein; Provisional; Region: PRK11677 592316001561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 592316001562 Predicted ATPase [General function prediction only]; Region: COG1485 592316001563 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 592316001564 23S rRNA interface [nucleotide binding]; other site 592316001565 L3 interface [polypeptide binding]; other site 592316001566 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 592316001567 stringent starvation protein A; Provisional; Region: sspA; PRK09481 592316001568 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 592316001569 C-terminal domain interface [polypeptide binding]; other site 592316001570 putative GSH binding site (G-site) [chemical binding]; other site 592316001571 dimer interface [polypeptide binding]; other site 592316001572 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 592316001573 dimer interface [polypeptide binding]; other site 592316001574 N-terminal domain interface [polypeptide binding]; other site 592316001575 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 592316001576 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 592316001577 Flavodoxin; Region: Flavodoxin_1; pfam00258 592316001578 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 592316001579 FAD binding pocket [chemical binding]; other site 592316001580 FAD binding motif [chemical binding]; other site 592316001581 catalytic residues [active] 592316001582 NAD binding pocket [chemical binding]; other site 592316001583 phosphate binding motif [ion binding]; other site 592316001584 beta-alpha-beta structure motif; other site 592316001585 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 592316001586 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 592316001587 active site 592316001588 dimer interface [polypeptide binding]; other site 592316001589 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 592316001590 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 592316001591 active site 592316001592 FMN binding site [chemical binding]; other site 592316001593 substrate binding site [chemical binding]; other site 592316001594 3Fe-4S cluster binding site [ion binding]; other site 592316001595 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 592316001596 domain_subunit interface; other site 592316001597 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 592316001598 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592316001599 putative active site [active] 592316001600 heme pocket [chemical binding]; other site 592316001601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316001602 dimer interface [polypeptide binding]; other site 592316001603 phosphorylation site [posttranslational modification] 592316001604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316001605 ATP binding site [chemical binding]; other site 592316001606 Mg2+ binding site [ion binding]; other site 592316001607 G-X-G motif; other site 592316001608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316001609 active site 592316001610 phosphorylation site [posttranslational modification] 592316001611 intermolecular recognition site; other site 592316001612 dimerization interface [polypeptide binding]; other site 592316001613 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 592316001614 putative binding surface; other site 592316001615 active site 592316001616 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 592316001617 Transglycosylase; Region: Transgly; cl17702 592316001618 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 592316001619 dimerization domain swap beta strand [polypeptide binding]; other site 592316001620 regulatory protein interface [polypeptide binding]; other site 592316001621 active site 592316001622 regulatory phosphorylation site [posttranslational modification]; other site 592316001623 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 592316001624 AAA domain; Region: AAA_18; pfam13238 592316001625 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 592316001626 active site 592316001627 phosphorylation site [posttranslational modification] 592316001628 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 592316001629 30S subunit binding site; other site 592316001630 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 592316001631 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 592316001632 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 592316001633 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 592316001634 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 592316001635 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 592316001636 Walker A/P-loop; other site 592316001637 ATP binding site [chemical binding]; other site 592316001638 Q-loop/lid; other site 592316001639 ABC transporter signature motif; other site 592316001640 Walker B; other site 592316001641 D-loop; other site 592316001642 H-loop/switch region; other site 592316001643 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 592316001644 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 592316001645 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 592316001646 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 592316001647 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 592316001648 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 592316001649 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 592316001650 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 592316001651 putative active site [active] 592316001652 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 592316001653 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 592316001654 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 592316001655 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 592316001656 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 592316001657 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 592316001658 Walker A/P-loop; other site 592316001659 ATP binding site [chemical binding]; other site 592316001660 Q-loop/lid; other site 592316001661 ABC transporter signature motif; other site 592316001662 Walker B; other site 592316001663 D-loop; other site 592316001664 H-loop/switch region; other site 592316001665 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 592316001666 conserved hypothetical integral membrane protein; Region: TIGR00056 592316001667 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 592316001668 mce related protein; Region: MCE; pfam02470 592316001669 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 592316001670 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 592316001671 anti sigma factor interaction site; other site 592316001672 regulatory phosphorylation site [posttranslational modification]; other site 592316001673 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 592316001674 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 592316001675 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 592316001676 hinge; other site 592316001677 active site 592316001678 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 592316001679 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 592316001680 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 592316001681 substrate binding pocket [chemical binding]; other site 592316001682 chain length determination region; other site 592316001683 substrate-Mg2+ binding site; other site 592316001684 catalytic residues [active] 592316001685 aspartate-rich region 1; other site 592316001686 active site lid residues [active] 592316001687 aspartate-rich region 2; other site 592316001688 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 592316001689 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 592316001690 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 592316001691 GTPase CgtA; Reviewed; Region: obgE; PRK12298 592316001692 GTP1/OBG; Region: GTP1_OBG; pfam01018 592316001693 Obg GTPase; Region: Obg; cd01898 592316001694 G1 box; other site 592316001695 GTP/Mg2+ binding site [chemical binding]; other site 592316001696 Switch I region; other site 592316001697 G2 box; other site 592316001698 G3 box; other site 592316001699 Switch II region; other site 592316001700 G4 box; other site 592316001701 G5 box; other site 592316001702 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 592316001703 CoenzymeA binding site [chemical binding]; other site 592316001704 subunit interaction site [polypeptide binding]; other site 592316001705 PHB binding site; other site 592316001706 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 592316001707 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 592316001708 putative NAD(P) binding site [chemical binding]; other site 592316001709 active site 592316001710 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 592316001711 hydrophobic substrate binding pocket; other site 592316001712 Isochorismatase family; Region: Isochorismatase; pfam00857 592316001713 active site 592316001714 conserved cis-peptide bond; other site 592316001715 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 592316001716 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 592316001717 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 592316001718 acyl-activating enzyme (AAE) consensus motif; other site 592316001719 active site 592316001720 AMP binding site [chemical binding]; other site 592316001721 substrate binding site [chemical binding]; other site 592316001722 isochorismate synthase EntC; Provisional; Region: PRK15016 592316001723 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 592316001724 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 592316001725 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 592316001726 intersubunit interface [polypeptide binding]; other site 592316001727 enterobactin exporter EntS; Provisional; Region: PRK10489 592316001728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316001729 putative substrate translocation pore; other site 592316001730 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 592316001731 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592316001732 ABC-ATPase subunit interface; other site 592316001733 dimer interface [polypeptide binding]; other site 592316001734 putative PBP binding regions; other site 592316001735 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 592316001736 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 592316001737 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592316001738 ABC-ATPase subunit interface; other site 592316001739 dimer interface [polypeptide binding]; other site 592316001740 putative PBP binding regions; other site 592316001741 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 592316001742 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 592316001743 Walker A/P-loop; other site 592316001744 ATP binding site [chemical binding]; other site 592316001745 Q-loop/lid; other site 592316001746 ABC transporter signature motif; other site 592316001747 Walker B; other site 592316001748 D-loop; other site 592316001749 H-loop/switch region; other site 592316001750 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 592316001751 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 592316001752 acyl-activating enzyme (AAE) consensus motif; other site 592316001753 AMP binding site [chemical binding]; other site 592316001754 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592316001755 MbtH-like protein; Region: MbtH; smart00923 592316001756 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 592316001757 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 592316001758 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 592316001759 outer membrane receptor FepA; Provisional; Region: PRK13524 592316001760 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316001761 N-terminal plug; other site 592316001762 ligand-binding site [chemical binding]; other site 592316001763 sensor protein BasS/PmrB; Provisional; Region: PRK10755 592316001764 HAMP domain; Region: HAMP; pfam00672 592316001765 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316001766 dimer interface [polypeptide binding]; other site 592316001767 phosphorylation site [posttranslational modification] 592316001768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316001769 ATP binding site [chemical binding]; other site 592316001770 Mg2+ binding site [ion binding]; other site 592316001771 G-X-G motif; other site 592316001772 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 592316001773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316001774 active site 592316001775 phosphorylation site [posttranslational modification] 592316001776 intermolecular recognition site; other site 592316001777 dimerization interface [polypeptide binding]; other site 592316001778 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592316001779 DNA binding site [nucleotide binding] 592316001780 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 592316001781 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 592316001782 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 592316001783 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 592316001784 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 592316001785 RNA-binding protein YhbY; Provisional; Region: PRK10343 592316001786 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 592316001787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316001788 S-adenosylmethionine binding site [chemical binding]; other site 592316001789 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 592316001790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316001791 Walker A motif; other site 592316001792 ATP binding site [chemical binding]; other site 592316001793 Walker B motif; other site 592316001794 arginine finger; other site 592316001795 Peptidase family M41; Region: Peptidase_M41; pfam01434 592316001796 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 592316001797 dihydropteroate synthase; Region: DHPS; TIGR01496 592316001798 substrate binding pocket [chemical binding]; other site 592316001799 dimer interface [polypeptide binding]; other site 592316001800 inhibitor binding site; inhibition site 592316001801 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 592316001802 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 592316001803 active site 592316001804 substrate binding site [chemical binding]; other site 592316001805 metal binding site [ion binding]; metal-binding site 592316001806 Preprotein translocase SecG subunit; Region: SecG; pfam03840 592316001807 ribosome maturation protein RimP; Reviewed; Region: PRK00092 592316001808 Sm and related proteins; Region: Sm_like; cl00259 592316001809 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 592316001810 putative oligomer interface [polypeptide binding]; other site 592316001811 putative RNA binding site [nucleotide binding]; other site 592316001812 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 592316001813 NusA N-terminal domain; Region: NusA_N; pfam08529 592316001814 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 592316001815 RNA binding site [nucleotide binding]; other site 592316001816 homodimer interface [polypeptide binding]; other site 592316001817 NusA-like KH domain; Region: KH_5; pfam13184 592316001818 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 592316001819 G-X-X-G motif; other site 592316001820 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 592316001821 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 592316001822 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 592316001823 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 592316001824 translation initiation factor IF-2; Region: IF-2; TIGR00487 592316001825 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 592316001826 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 592316001827 G1 box; other site 592316001828 putative GEF interaction site [polypeptide binding]; other site 592316001829 GTP/Mg2+ binding site [chemical binding]; other site 592316001830 Switch I region; other site 592316001831 G2 box; other site 592316001832 G3 box; other site 592316001833 Switch II region; other site 592316001834 G4 box; other site 592316001835 G5 box; other site 592316001836 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 592316001837 Translation-initiation factor 2; Region: IF-2; pfam11987 592316001838 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 592316001839 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 592316001840 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 592316001841 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 592316001842 RNA binding site [nucleotide binding]; other site 592316001843 active site 592316001844 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 592316001845 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 592316001846 16S/18S rRNA binding site [nucleotide binding]; other site 592316001847 S13e-L30e interaction site [polypeptide binding]; other site 592316001848 25S rRNA binding site [nucleotide binding]; other site 592316001849 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 592316001850 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 592316001851 RNase E interface [polypeptide binding]; other site 592316001852 trimer interface [polypeptide binding]; other site 592316001853 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 592316001854 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 592316001855 RNase E interface [polypeptide binding]; other site 592316001856 trimer interface [polypeptide binding]; other site 592316001857 active site 592316001858 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 592316001859 putative nucleic acid binding region [nucleotide binding]; other site 592316001860 G-X-X-G motif; other site 592316001861 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 592316001862 RNA binding site [nucleotide binding]; other site 592316001863 domain interface; other site 592316001864 lipoprotein NlpI; Provisional; Region: PRK11189 592316001865 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592316001866 binding surface 592316001867 TPR motif; other site 592316001868 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 592316001869 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 592316001870 ATP binding site [chemical binding]; other site 592316001871 Mg++ binding site [ion binding]; other site 592316001872 motif III; other site 592316001873 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592316001874 nucleotide binding region [chemical binding]; other site 592316001875 ATP-binding site [chemical binding]; other site 592316001876 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 592316001877 putative RNA binding site [nucleotide binding]; other site 592316001878 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 592316001879 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316001880 NAD(P) binding site [chemical binding]; other site 592316001881 active site 592316001882 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 592316001883 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 592316001884 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316001885 hypothetical protein; Provisional; Region: PRK10508 592316001886 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 592316001887 putative protease; Provisional; Region: PRK15447 592316001888 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 592316001889 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 592316001890 Peptidase family U32; Region: Peptidase_U32; pfam01136 592316001891 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 592316001892 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316001893 Coenzyme A binding pocket [chemical binding]; other site 592316001894 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 592316001895 GIY-YIG motif/motif A; other site 592316001896 putative active site [active] 592316001897 putative metal binding site [ion binding]; other site 592316001898 hypothetical protein; Provisional; Region: PRK03467 592316001899 Predicted permease; Region: DUF318; cl17795 592316001900 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 592316001901 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592316001902 FeS/SAM binding site; other site 592316001903 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 592316001904 ATP cone domain; Region: ATP-cone; pfam03477 592316001905 Class III ribonucleotide reductase; Region: RNR_III; cd01675 592316001906 effector binding site; other site 592316001907 active site 592316001908 Zn binding site [ion binding]; other site 592316001909 glycine loop; other site 592316001910 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 592316001911 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 592316001912 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 592316001913 active site 592316001914 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 592316001915 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 592316001916 homotrimer interaction site [polypeptide binding]; other site 592316001917 putative active site [active] 592316001918 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 592316001919 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 592316001920 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 592316001921 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 592316001922 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 592316001923 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 592316001924 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 592316001925 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 592316001926 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 592316001927 RNase E inhibitor protein; Provisional; Region: PRK11191 592316001928 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 592316001929 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 592316001930 active site 592316001931 dinuclear metal binding site [ion binding]; other site 592316001932 dimerization interface [polypeptide binding]; other site 592316001933 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 592316001934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316001935 Coenzyme A binding pocket [chemical binding]; other site 592316001936 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 592316001937 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 592316001938 HIGH motif; other site 592316001939 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 592316001940 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 592316001941 active site 592316001942 KMSKS motif; other site 592316001943 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 592316001944 tRNA binding surface [nucleotide binding]; other site 592316001945 anticodon binding site; other site 592316001946 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 592316001947 DNA polymerase III subunit chi; Validated; Region: PRK05728 592316001948 multifunctional aminopeptidase A; Provisional; Region: PRK00913 592316001949 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 592316001950 interface (dimer of trimers) [polypeptide binding]; other site 592316001951 Substrate-binding/catalytic site; other site 592316001952 Zn-binding sites [ion binding]; other site 592316001953 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 592316001954 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 592316001955 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 592316001956 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 592316001957 Predicted membrane protein [Function unknown]; Region: COG2733 592316001958 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 592316001959 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 592316001960 Walker A motif; other site 592316001961 ATP binding site [chemical binding]; other site 592316001962 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592316001963 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 592316001964 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 592316001965 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 592316001966 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 592316001967 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316001968 Cytochrome c; Region: Cytochrom_C; pfam00034 592316001969 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316001970 Cytochrome c; Region: Cytochrom_C; pfam00034 592316001971 inner membrane protein; Provisional; Region: PRK10995 592316001972 hypothetical protein; Provisional; Region: PRK11667 592316001973 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 592316001974 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592316001975 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316001976 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 592316001977 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 592316001978 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 592316001979 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592316001980 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316001981 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316001982 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316001983 dimerization interface [polypeptide binding]; other site 592316001984 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 592316001985 hypothetical protein; Provisional; Region: PRK10396 592316001986 yecA family protein; Region: ygfB_yecA; TIGR02292 592316001987 SEC-C motif; Region: SEC-C; pfam02810 592316001988 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 592316001989 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 592316001990 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 592316001991 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 592316001992 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 592316001993 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 592316001994 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316001995 DNA-binding site [nucleotide binding]; DNA binding site 592316001996 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316001997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316001998 homodimer interface [polypeptide binding]; other site 592316001999 catalytic residue [active] 592316002000 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 592316002001 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 592316002002 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 592316002003 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 592316002004 phosphoglycerol transferase I; Provisional; Region: PRK03776 592316002005 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 592316002006 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 592316002007 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316002008 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316002009 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 592316002010 putative effector binding pocket; other site 592316002011 dimerization interface [polypeptide binding]; other site 592316002012 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 592316002013 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 592316002014 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 592316002015 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 592316002016 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 592316002017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316002018 metabolite-proton symporter; Region: 2A0106; TIGR00883 592316002019 putative substrate translocation pore; other site 592316002020 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592316002021 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316002022 DNA binding site [nucleotide binding] 592316002023 domain linker motif; other site 592316002024 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 592316002025 dimerization interface [polypeptide binding]; other site 592316002026 ligand binding site [chemical binding]; other site 592316002027 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 592316002028 active site 592316002029 putative sialic acid transporter; Region: 2A0112; TIGR00891 592316002030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316002031 putative substrate translocation pore; other site 592316002032 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 592316002033 putative deacylase active site [active] 592316002034 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 592316002035 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 592316002036 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 592316002037 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592316002038 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316002039 metal binding site [ion binding]; metal-binding site 592316002040 active site 592316002041 I-site; other site 592316002042 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 592316002043 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 592316002044 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 592316002045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316002046 S-adenosylmethionine binding site [chemical binding]; other site 592316002047 DNA polymerase III subunit psi; Validated; Region: PRK06856 592316002048 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 592316002049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316002050 Coenzyme A binding pocket [chemical binding]; other site 592316002051 dUMP phosphatase; Provisional; Region: PRK09449 592316002052 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316002053 motif II; other site 592316002054 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 592316002055 HipA-like N-terminal domain; Region: HipA_N; pfam07805 592316002056 HipA-like C-terminal domain; Region: HipA_C; pfam07804 592316002057 hypothetical protein; Provisional; Region: PRK11246 592316002058 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 592316002059 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316002060 motif I; other site 592316002061 motif II; other site 592316002062 DNA repair protein RadA; Region: sms; TIGR00416 592316002063 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 592316002064 Walker A motif/ATP binding site; other site 592316002065 ATP binding site [chemical binding]; other site 592316002066 Walker B motif; other site 592316002067 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 592316002068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316002069 non-specific DNA binding site [nucleotide binding]; other site 592316002070 salt bridge; other site 592316002071 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 592316002072 sequence-specific DNA binding site [nucleotide binding]; other site 592316002073 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 592316002074 active site 592316002075 (T/H)XGH motif; other site 592316002076 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 592316002077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316002078 D-galactonate transporter; Region: 2A0114; TIGR00893 592316002079 putative substrate translocation pore; other site 592316002080 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 592316002081 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 592316002082 active site pocket [active] 592316002083 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 592316002084 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592316002085 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592316002086 ABC transporter; Region: ABC_tran_2; pfam12848 592316002087 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592316002088 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 592316002089 putative ligand binding site [chemical binding]; other site 592316002090 putative NAD binding site [chemical binding]; other site 592316002091 catalytic site [active] 592316002092 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 592316002093 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 592316002094 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 592316002095 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592316002096 dimerization interface [polypeptide binding]; other site 592316002097 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592316002098 dimer interface [polypeptide binding]; other site 592316002099 putative CheW interface [polypeptide binding]; other site 592316002100 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 592316002101 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 592316002102 Walker A/P-loop; other site 592316002103 ATP binding site [chemical binding]; other site 592316002104 Q-loop/lid; other site 592316002105 ABC transporter signature motif; other site 592316002106 Walker B; other site 592316002107 D-loop; other site 592316002108 H-loop/switch region; other site 592316002109 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 592316002110 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 592316002111 Walker A/P-loop; other site 592316002112 ATP binding site [chemical binding]; other site 592316002113 Q-loop/lid; other site 592316002114 ABC transporter signature motif; other site 592316002115 Walker B; other site 592316002116 D-loop; other site 592316002117 H-loop/switch region; other site 592316002118 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 592316002119 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 592316002120 TM-ABC transporter signature motif; other site 592316002121 HEAT repeats; Region: HEAT_2; pfam13646 592316002122 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 592316002123 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316002124 TM-ABC transporter signature motif; other site 592316002125 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 592316002126 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 592316002127 putative ligand binding site [chemical binding]; other site 592316002128 Transcriptional regulators [Transcription]; Region: GntR; COG1802 592316002129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316002130 DNA-binding site [nucleotide binding]; DNA binding site 592316002131 FCD domain; Region: FCD; pfam07729 592316002132 urea carboxylase; Region: urea_carbox; TIGR02712 592316002133 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592316002134 ATP-grasp domain; Region: ATP-grasp_4; cl17255 592316002135 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 592316002136 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 592316002137 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 592316002138 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 592316002139 carboxyltransferase (CT) interaction site; other site 592316002140 biotinylation site [posttranslational modification]; other site 592316002141 allophanate hydrolase; Provisional; Region: PRK08186 592316002142 Amidase; Region: Amidase; cl11426 592316002143 lytic murein transglycosylase; Provisional; Region: PRK11619 592316002144 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 592316002145 N-acetyl-D-glucosamine binding site [chemical binding]; other site 592316002146 catalytic residue [active] 592316002147 Trp operon repressor; Provisional; Region: PRK01381 592316002148 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 592316002149 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 592316002150 catalytic core [active] 592316002151 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 592316002152 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316002153 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 592316002154 hypothetical protein; Provisional; Region: PRK10756 592316002155 CreA protein; Region: CreA; pfam05981 592316002156 two-component response regulator; Provisional; Region: PRK11173 592316002157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316002158 active site 592316002159 phosphorylation site [posttranslational modification] 592316002160 intermolecular recognition site; other site 592316002161 dimerization interface [polypeptide binding]; other site 592316002162 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592316002163 DNA binding site [nucleotide binding] 592316002164 putative RNA methyltransferase; Provisional; Region: PRK10433 592316002165 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 592316002166 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 592316002167 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 592316002168 putative catalytic residues [active] 592316002169 putative nucleotide binding site [chemical binding]; other site 592316002170 putative aspartate binding site [chemical binding]; other site 592316002171 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 592316002172 dimer interface [polypeptide binding]; other site 592316002173 putative threonine allosteric regulatory site; other site 592316002174 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 592316002175 putative threonine allosteric regulatory site; other site 592316002176 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 592316002177 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 592316002178 homoserine kinase; Provisional; Region: PRK01212 592316002179 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 592316002180 threonine synthase; Validated; Region: PRK09225 592316002181 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 592316002182 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592316002183 catalytic residue [active] 592316002184 hypothetical protein; Validated; Region: PRK02101 592316002185 transaldolase-like protein; Provisional; Region: PTZ00411 592316002186 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 592316002187 active site 592316002188 dimer interface [polypeptide binding]; other site 592316002189 catalytic residue [active] 592316002190 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 592316002191 MPT binding site; other site 592316002192 trimer interface [polypeptide binding]; other site 592316002193 metabolite-proton symporter; Region: 2A0106; TIGR00883 592316002194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316002195 putative substrate translocation pore; other site 592316002196 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 592316002197 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 592316002198 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 592316002199 nucleotide binding site [chemical binding]; other site 592316002200 chaperone protein DnaJ; Provisional; Region: PRK10767 592316002201 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 592316002202 HSP70 interaction site [polypeptide binding]; other site 592316002203 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 592316002204 substrate binding site [polypeptide binding]; other site 592316002205 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 592316002206 Zn binding sites [ion binding]; other site 592316002207 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 592316002208 dimer interface [polypeptide binding]; other site 592316002209 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 592316002210 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 592316002211 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316002212 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 592316002213 putative dimerization interface [polypeptide binding]; other site 592316002214 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 592316002215 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 592316002216 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 592316002217 active site 592316002218 Riboflavin kinase; Region: Flavokinase; smart00904 592316002219 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 592316002220 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592316002221 active site 592316002222 HIGH motif; other site 592316002223 nucleotide binding site [chemical binding]; other site 592316002224 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 592316002225 active site 592316002226 KMSKS motif; other site 592316002227 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 592316002228 tRNA binding surface [nucleotide binding]; other site 592316002229 anticodon binding site; other site 592316002230 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 592316002231 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 592316002232 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 592316002233 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 592316002234 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 592316002235 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 592316002236 dihydrodipicolinate reductase; Provisional; Region: PRK00048 592316002237 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 592316002238 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 592316002239 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 592316002240 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 592316002241 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 592316002242 catalytic site [active] 592316002243 subunit interface [polypeptide binding]; other site 592316002244 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 592316002245 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592316002246 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 592316002247 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 592316002248 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592316002249 ATP-grasp domain; Region: ATP-grasp_4; cl17255 592316002250 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 592316002251 IMP binding site; other site 592316002252 dimer interface [polypeptide binding]; other site 592316002253 interdomain contacts; other site 592316002254 partial ornithine binding site; other site 592316002255 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 592316002256 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 592316002257 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 592316002258 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 592316002259 folate binding site [chemical binding]; other site 592316002260 NADP+ binding site [chemical binding]; other site 592316002261 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 592316002262 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 592316002263 active site 592316002264 metal binding site [ion binding]; metal-binding site 592316002265 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 592316002266 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 592316002267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316002268 S-adenosylmethionine binding site [chemical binding]; other site 592316002269 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 592316002270 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 592316002271 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 592316002272 SurA N-terminal domain; Region: SurA_N; pfam09312 592316002273 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 592316002274 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 592316002275 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 592316002276 OstA-like protein; Region: OstA; pfam03968 592316002277 Organic solvent tolerance protein; Region: OstA_C; pfam04453 592316002278 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 592316002279 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 592316002280 putative metal binding site [ion binding]; other site 592316002281 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 592316002282 HSP70 interaction site [polypeptide binding]; other site 592316002283 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 592316002284 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 592316002285 active site 592316002286 ATP-dependent helicase HepA; Validated; Region: PRK04914 592316002287 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592316002288 ATP binding site [chemical binding]; other site 592316002289 putative Mg++ binding site [ion binding]; other site 592316002290 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592316002291 nucleotide binding region [chemical binding]; other site 592316002292 ATP-binding site [chemical binding]; other site 592316002293 DNA polymerase II; Reviewed; Region: PRK05762 592316002294 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 592316002295 active site 592316002296 catalytic site [active] 592316002297 substrate binding site [chemical binding]; other site 592316002298 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 592316002299 active site 592316002300 metal-binding site 592316002301 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 592316002302 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 592316002303 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 592316002304 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316002305 Walker A/P-loop; other site 592316002306 ATP binding site [chemical binding]; other site 592316002307 Q-loop/lid; other site 592316002308 ABC transporter signature motif; other site 592316002309 Walker B; other site 592316002310 D-loop; other site 592316002311 H-loop/switch region; other site 592316002312 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 592316002313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316002314 dimer interface [polypeptide binding]; other site 592316002315 conserved gate region; other site 592316002316 putative PBP binding loops; other site 592316002317 ABC-ATPase subunit interface; other site 592316002318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316002319 dimer interface [polypeptide binding]; other site 592316002320 conserved gate region; other site 592316002321 putative PBP binding loops; other site 592316002322 ABC-ATPase subunit interface; other site 592316002323 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 592316002324 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 592316002325 transcriptional regulator SgrR; Provisional; Region: PRK13626 592316002326 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 592316002327 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 592316002328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316002329 sugar efflux transporter; Region: 2A0120; TIGR00899 592316002330 putative substrate translocation pore; other site 592316002331 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 592316002332 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 592316002333 substrate binding site [chemical binding]; other site 592316002334 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 592316002335 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 592316002336 substrate binding site [chemical binding]; other site 592316002337 ligand binding site [chemical binding]; other site 592316002338 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 592316002339 tartrate dehydrogenase; Region: TTC; TIGR02089 592316002340 2-isopropylmalate synthase; Validated; Region: PRK00915 592316002341 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 592316002342 active site 592316002343 catalytic residues [active] 592316002344 metal binding site [ion binding]; metal-binding site 592316002345 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 592316002346 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 592316002347 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 592316002348 PYR/PP interface [polypeptide binding]; other site 592316002349 dimer interface [polypeptide binding]; other site 592316002350 TPP binding site [chemical binding]; other site 592316002351 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 592316002352 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 592316002353 TPP-binding site [chemical binding]; other site 592316002354 dimer interface [polypeptide binding]; other site 592316002355 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 592316002356 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 592316002357 putative valine binding site [chemical binding]; other site 592316002358 dimer interface [polypeptide binding]; other site 592316002359 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 592316002360 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 592316002361 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316002362 DNA binding site [nucleotide binding] 592316002363 domain linker motif; other site 592316002364 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 592316002365 dimerization interface [polypeptide binding]; other site 592316002366 ligand binding site [chemical binding]; other site 592316002367 cell division protein MraZ; Reviewed; Region: PRK00326 592316002368 MraZ protein; Region: MraZ; pfam02381 592316002369 MraZ protein; Region: MraZ; pfam02381 592316002370 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 592316002371 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 592316002372 cell division protein FtsL; Provisional; Region: PRK10772 592316002373 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 592316002374 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 592316002375 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 592316002376 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 592316002377 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 592316002378 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592316002379 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592316002380 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 592316002381 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 592316002382 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592316002383 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592316002384 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 592316002385 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 592316002386 Mg++ binding site [ion binding]; other site 592316002387 putative catalytic motif [active] 592316002388 putative substrate binding site [chemical binding]; other site 592316002389 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 592316002390 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592316002391 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592316002392 cell division protein FtsW; Provisional; Region: PRK10774 592316002393 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 592316002394 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 592316002395 active site 592316002396 homodimer interface [polypeptide binding]; other site 592316002397 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 592316002398 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 592316002399 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592316002400 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592316002401 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 592316002402 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 592316002403 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 592316002404 cell division protein FtsQ; Provisional; Region: PRK10775 592316002405 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 592316002406 Cell division protein FtsQ; Region: FtsQ; pfam03799 592316002407 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 592316002408 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 592316002409 Cell division protein FtsA; Region: FtsA; pfam14450 592316002410 cell division protein FtsZ; Validated; Region: PRK09330 592316002411 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 592316002412 nucleotide binding site [chemical binding]; other site 592316002413 SulA interaction site; other site 592316002414 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 592316002415 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 592316002416 SecA regulator SecM; Provisional; Region: PRK02943 592316002417 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 592316002418 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 592316002419 SEC-C motif; Region: SEC-C; pfam02810 592316002420 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 592316002421 active site 592316002422 8-oxo-dGMP binding site [chemical binding]; other site 592316002423 nudix motif; other site 592316002424 metal binding site [ion binding]; metal-binding site 592316002425 DNA gyrase inhibitor; Reviewed; Region: PRK00418 592316002426 hypothetical protein; Provisional; Region: PRK05287 592316002427 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 592316002428 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 592316002429 CoA-binding site [chemical binding]; other site 592316002430 ATP-binding [chemical binding]; other site 592316002431 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 592316002432 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 592316002433 active site 592316002434 type IV pilin biogenesis protein; Provisional; Region: PRK10573 592316002435 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 592316002436 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 592316002437 hypothetical protein; Provisional; Region: PRK10436 592316002438 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 592316002439 Walker A motif; other site 592316002440 ATP binding site [chemical binding]; other site 592316002441 Walker B motif; other site 592316002442 putative major pilin subunit; Provisional; Region: PRK10574 592316002443 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 592316002444 Pilin (bacterial filament); Region: Pilin; pfam00114 592316002445 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 592316002446 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 592316002447 dimerization interface [polypeptide binding]; other site 592316002448 active site 592316002449 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 592316002450 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 592316002451 amidase catalytic site [active] 592316002452 Zn binding residues [ion binding]; other site 592316002453 substrate binding site [chemical binding]; other site 592316002454 regulatory protein AmpE; Provisional; Region: PRK10987 592316002455 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 592316002456 active site 592316002457 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 592316002458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316002459 putative substrate translocation pore; other site 592316002460 aromatic amino acid transporter; Provisional; Region: PRK10238 592316002461 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 592316002462 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316002463 DNA-binding site [nucleotide binding]; DNA binding site 592316002464 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 592316002465 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 592316002466 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 592316002467 dimer interface [polypeptide binding]; other site 592316002468 TPP-binding site [chemical binding]; other site 592316002469 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 592316002470 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 592316002471 E3 interaction surface; other site 592316002472 lipoyl attachment site [posttranslational modification]; other site 592316002473 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 592316002474 E3 interaction surface; other site 592316002475 lipoyl attachment site [posttranslational modification]; other site 592316002476 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 592316002477 E3 interaction surface; other site 592316002478 lipoyl attachment site [posttranslational modification]; other site 592316002479 e3 binding domain; Region: E3_binding; pfam02817 592316002480 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 592316002481 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 592316002482 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592316002483 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592316002484 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 592316002485 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316002486 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316002487 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 592316002488 putative effector binding pocket; other site 592316002489 putative dimerization interface [polypeptide binding]; other site 592316002490 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592316002491 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592316002492 active site 592316002493 catalytic tetrad [active] 592316002494 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 592316002495 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 592316002496 substrate binding site [chemical binding]; other site 592316002497 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 592316002498 substrate binding site [chemical binding]; other site 592316002499 ligand binding site [chemical binding]; other site 592316002500 Spore Coat Protein U domain; Region: SCPU; pfam05229 592316002501 Spore Coat Protein U domain; Region: SCPU; pfam05229 592316002502 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 592316002503 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 592316002504 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 592316002505 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 592316002506 PapC C-terminal domain; Region: PapC_C; pfam13953 592316002507 Spore Coat Protein U domain; Region: SCPU; cl02253 592316002508 Uncharacterized secreted protein [Function unknown]; Region: COG5430 592316002509 hypothetical protein; Provisional; Region: PRK05248 592316002510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316002511 Putative cyclase; Region: Cyclase; pfam04199 592316002512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316002513 D-galactonate transporter; Region: 2A0114; TIGR00893 592316002514 putative substrate translocation pore; other site 592316002515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316002516 D-galactonate transporter; Region: 2A0114; TIGR00893 592316002517 putative substrate translocation pore; other site 592316002518 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 592316002519 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 592316002520 putative ligand binding site [chemical binding]; other site 592316002521 putative NAD binding site [chemical binding]; other site 592316002522 catalytic site [active] 592316002523 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 592316002524 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 592316002525 inhibitor site; inhibition site 592316002526 active site 592316002527 dimer interface [polypeptide binding]; other site 592316002528 catalytic residue [active] 592316002529 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 592316002530 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 592316002531 active site 592316002532 NAD binding site [chemical binding]; other site 592316002533 metal binding site [ion binding]; metal-binding site 592316002534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 592316002535 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 592316002536 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 592316002537 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 592316002538 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 592316002539 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 592316002540 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 592316002541 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 592316002542 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 592316002543 FAD binding pocket [chemical binding]; other site 592316002544 FAD binding motif [chemical binding]; other site 592316002545 phosphate binding motif [ion binding]; other site 592316002546 beta-alpha-beta structure motif; other site 592316002547 NAD binding pocket [chemical binding]; other site 592316002548 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 592316002549 spermidine synthase; Provisional; Region: PRK00811 592316002550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316002551 S-adenosylmethionine binding site [chemical binding]; other site 592316002552 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 592316002553 multicopper oxidase; Provisional; Region: PRK10965 592316002554 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 592316002555 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 592316002556 methionine gamma-lyase; Validated; Region: PRK07049 592316002557 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 592316002558 homodimer interface [polypeptide binding]; other site 592316002559 substrate-cofactor binding pocket; other site 592316002560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316002561 catalytic residue [active] 592316002562 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592316002563 active site 592316002564 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 592316002565 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 592316002566 Walker A/P-loop; other site 592316002567 ATP binding site [chemical binding]; other site 592316002568 Q-loop/lid; other site 592316002569 ABC transporter signature motif; other site 592316002570 Walker B; other site 592316002571 D-loop; other site 592316002572 H-loop/switch region; other site 592316002573 inner membrane transport permease; Provisional; Region: PRK15066 592316002574 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 592316002575 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 592316002576 tetramerization interface [polypeptide binding]; other site 592316002577 active site 592316002578 Pantoate-beta-alanine ligase; Region: PanC; cd00560 592316002579 pantoate--beta-alanine ligase; Region: panC; TIGR00018 592316002580 active site 592316002581 ATP-binding site [chemical binding]; other site 592316002582 pantoate-binding site; other site 592316002583 HXXH motif; other site 592316002584 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 592316002585 oligomerization interface [polypeptide binding]; other site 592316002586 active site 592316002587 metal binding site [ion binding]; metal-binding site 592316002588 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 592316002589 catalytic center binding site [active] 592316002590 ATP binding site [chemical binding]; other site 592316002591 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 592316002592 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 592316002593 active site 592316002594 NTP binding site [chemical binding]; other site 592316002595 metal binding triad [ion binding]; metal-binding site 592316002596 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 592316002597 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 592316002598 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 592316002599 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 592316002600 active site 592316002601 nucleotide binding site [chemical binding]; other site 592316002602 HIGH motif; other site 592316002603 KMSKS motif; other site 592316002604 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 592316002605 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 592316002606 2'-5' RNA ligase; Provisional; Region: PRK15124 592316002607 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 592316002608 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 592316002609 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592316002610 ATP binding site [chemical binding]; other site 592316002611 putative Mg++ binding site [ion binding]; other site 592316002612 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592316002613 nucleotide binding region [chemical binding]; other site 592316002614 ATP-binding site [chemical binding]; other site 592316002615 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 592316002616 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 592316002617 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 592316002618 Transglycosylase; Region: Transgly; pfam00912 592316002619 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 592316002620 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 592316002621 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316002622 N-terminal plug; other site 592316002623 ligand-binding site [chemical binding]; other site 592316002624 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 592316002625 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 592316002626 Walker A/P-loop; other site 592316002627 ATP binding site [chemical binding]; other site 592316002628 Q-loop/lid; other site 592316002629 ABC transporter signature motif; other site 592316002630 Walker B; other site 592316002631 D-loop; other site 592316002632 H-loop/switch region; other site 592316002633 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 592316002634 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 592316002635 siderophore binding site; other site 592316002636 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 592316002637 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592316002638 ABC-ATPase subunit interface; other site 592316002639 dimer interface [polypeptide binding]; other site 592316002640 putative PBP binding regions; other site 592316002641 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592316002642 ABC-ATPase subunit interface; other site 592316002643 dimer interface [polypeptide binding]; other site 592316002644 putative PBP binding regions; other site 592316002645 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 592316002646 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592316002647 inhibitor-cofactor binding pocket; inhibition site 592316002648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316002649 catalytic residue [active] 592316002650 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 592316002651 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 592316002652 cobalamin binding residues [chemical binding]; other site 592316002653 putative BtuC binding residues; other site 592316002654 dimer interface [polypeptide binding]; other site 592316002655 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 592316002656 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 592316002657 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 592316002658 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592316002659 Zn2+ binding site [ion binding]; other site 592316002660 Mg2+ binding site [ion binding]; other site 592316002661 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 592316002662 serine endoprotease; Provisional; Region: PRK10942 592316002663 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 592316002664 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 592316002665 protein binding site [polypeptide binding]; other site 592316002666 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 592316002667 protein binding site [polypeptide binding]; other site 592316002668 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 592316002669 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 592316002670 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 592316002671 Alginate lyase; Region: Alginate_lyase; pfam05426 592316002672 hypothetical protein; Provisional; Region: PRK13677 592316002673 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 592316002674 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 592316002675 trimer interface [polypeptide binding]; other site 592316002676 active site 592316002677 substrate binding site [chemical binding]; other site 592316002678 CoA binding site [chemical binding]; other site 592316002679 PII uridylyl-transferase; Provisional; Region: PRK05007 592316002680 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 592316002681 metal binding triad; other site 592316002682 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 592316002683 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592316002684 Zn2+ binding site [ion binding]; other site 592316002685 Mg2+ binding site [ion binding]; other site 592316002686 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 592316002687 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 592316002688 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 592316002689 active site 592316002690 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 592316002691 rRNA interaction site [nucleotide binding]; other site 592316002692 S8 interaction site; other site 592316002693 putative laminin-1 binding site; other site 592316002694 elongation factor Ts; Provisional; Region: tsf; PRK09377 592316002695 UBA/TS-N domain; Region: UBA; pfam00627 592316002696 Elongation factor TS; Region: EF_TS; pfam00889 592316002697 Elongation factor TS; Region: EF_TS; pfam00889 592316002698 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 592316002699 putative nucleotide binding site [chemical binding]; other site 592316002700 uridine monophosphate binding site [chemical binding]; other site 592316002701 homohexameric interface [polypeptide binding]; other site 592316002702 ribosome recycling factor; Reviewed; Region: frr; PRK00083 592316002703 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 592316002704 hinge region; other site 592316002705 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 592316002706 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 592316002707 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 592316002708 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 592316002709 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 592316002710 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 592316002711 catalytic residue [active] 592316002712 putative FPP diphosphate binding site; other site 592316002713 putative FPP binding hydrophobic cleft; other site 592316002714 dimer interface [polypeptide binding]; other site 592316002715 putative IPP diphosphate binding site; other site 592316002716 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 592316002717 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 592316002718 zinc metallopeptidase RseP; Provisional; Region: PRK10779 592316002719 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 592316002720 active site 592316002721 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 592316002722 protein binding site [polypeptide binding]; other site 592316002723 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 592316002724 protein binding site [polypeptide binding]; other site 592316002725 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 592316002726 putative substrate binding region [chemical binding]; other site 592316002727 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 592316002728 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 592316002729 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 592316002730 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 592316002731 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 592316002732 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 592316002733 Surface antigen; Region: Bac_surface_Ag; pfam01103 592316002734 periplasmic chaperone; Provisional; Region: PRK10780 592316002735 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 592316002736 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 592316002737 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 592316002738 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 592316002739 trimer interface [polypeptide binding]; other site 592316002740 active site 592316002741 UDP-GlcNAc binding site [chemical binding]; other site 592316002742 lipid binding site [chemical binding]; lipid-binding site 592316002743 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 592316002744 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 592316002745 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 592316002746 active site 592316002747 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 592316002748 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 592316002749 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 592316002750 RNA/DNA hybrid binding site [nucleotide binding]; other site 592316002751 active site 592316002752 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 592316002753 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 592316002754 putative active site [active] 592316002755 putative PHP Thumb interface [polypeptide binding]; other site 592316002756 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 592316002757 generic binding surface II; other site 592316002758 generic binding surface I; other site 592316002759 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 592316002760 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 592316002761 lysine decarboxylase LdcC; Provisional; Region: PRK15399 592316002762 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 592316002763 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 592316002764 homodimer interface [polypeptide binding]; other site 592316002765 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316002766 catalytic residue [active] 592316002767 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 592316002768 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 592316002769 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592316002770 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 592316002771 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 592316002772 Ligand Binding Site [chemical binding]; other site 592316002773 TilS substrate binding domain; Region: TilS; pfam09179 592316002774 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 592316002775 Cytochrome c553 [Energy production and conversion]; Region: COG2863 592316002776 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 592316002777 hypothetical protein; Provisional; Region: PRK04964 592316002778 hypothetical protein; Provisional; Region: PRK09256 592316002779 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 592316002780 prolyl-tRNA synthetase; Provisional; Region: PRK09194 592316002781 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 592316002782 dimer interface [polypeptide binding]; other site 592316002783 motif 1; other site 592316002784 active site 592316002785 motif 2; other site 592316002786 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 592316002787 putative deacylase active site [active] 592316002788 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 592316002789 active site 592316002790 motif 3; other site 592316002791 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 592316002792 anticodon binding site; other site 592316002793 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 592316002794 homodimer interaction site [polypeptide binding]; other site 592316002795 cofactor binding site; other site 592316002796 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 592316002797 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 592316002798 lipoprotein, YaeC family; Region: TIGR00363 592316002799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316002800 dimer interface [polypeptide binding]; other site 592316002801 conserved gate region; other site 592316002802 ABC-ATPase subunit interface; other site 592316002803 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 592316002804 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 592316002805 Walker A/P-loop; other site 592316002806 ATP binding site [chemical binding]; other site 592316002807 Q-loop/lid; other site 592316002808 ABC transporter signature motif; other site 592316002809 Walker B; other site 592316002810 D-loop; other site 592316002811 H-loop/switch region; other site 592316002812 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 592316002813 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 592316002814 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316002815 active site 592316002816 motif I; other site 592316002817 motif II; other site 592316002818 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592316002819 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592316002820 active site 592316002821 catalytic tetrad [active] 592316002822 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316002823 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316002824 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316002825 dimerization interface [polypeptide binding]; other site 592316002826 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 592316002827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316002828 putative substrate translocation pore; other site 592316002829 hypothetical protein; Provisional; Region: PRK05421 592316002830 putative catalytic site [active] 592316002831 putative metal binding site [ion binding]; other site 592316002832 putative phosphate binding site [ion binding]; other site 592316002833 putative catalytic site [active] 592316002834 putative phosphate binding site [ion binding]; other site 592316002835 putative metal binding site [ion binding]; other site 592316002836 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 592316002837 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 592316002838 N-acetyl-D-glucosamine binding site [chemical binding]; other site 592316002839 catalytic residue [active] 592316002840 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592316002841 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592316002842 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 592316002843 Methyltransferase domain; Region: Methyltransf_11; pfam08241 592316002844 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 592316002845 RNA/DNA hybrid binding site [nucleotide binding]; other site 592316002846 active site 592316002847 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 592316002848 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 592316002849 active site 592316002850 catalytic site [active] 592316002851 substrate binding site [chemical binding]; other site 592316002852 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 592316002853 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 592316002854 Na binding site [ion binding]; other site 592316002855 putative substrate binding site [chemical binding]; other site 592316002856 Transcriptional regulators [Transcription]; Region: GntR; COG1802 592316002857 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316002858 DNA-binding site [nucleotide binding]; DNA binding site 592316002859 FCD domain; Region: FCD; pfam07729 592316002860 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 592316002861 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 592316002862 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 592316002863 active site 592316002864 catalytic site [active] 592316002865 tetramer interface [polypeptide binding]; other site 592316002866 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 592316002867 amidase; Provisional; Region: PRK09201 592316002868 Amidase; Region: Amidase; pfam01425 592316002869 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 592316002870 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 592316002871 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 592316002872 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 592316002873 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 592316002874 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 592316002875 putative active site [active] 592316002876 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316002877 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316002878 substrate binding pocket [chemical binding]; other site 592316002879 membrane-bound complex binding site; other site 592316002880 hinge residues; other site 592316002881 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316002882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316002883 dimer interface [polypeptide binding]; other site 592316002884 conserved gate region; other site 592316002885 putative PBP binding loops; other site 592316002886 ABC-ATPase subunit interface; other site 592316002887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 592316002888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316002889 ABC-ATPase subunit interface; other site 592316002890 putative PBP binding loops; other site 592316002891 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316002892 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316002893 Walker A/P-loop; other site 592316002894 ATP binding site [chemical binding]; other site 592316002895 Q-loop/lid; other site 592316002896 ABC transporter signature motif; other site 592316002897 Walker B; other site 592316002898 D-loop; other site 592316002899 H-loop/switch region; other site 592316002900 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 592316002901 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592316002902 catalytic residue [active] 592316002903 allantoate amidohydrolase; Reviewed; Region: PRK09290 592316002904 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 592316002905 active site 592316002906 metal binding site [ion binding]; metal-binding site 592316002907 dimer interface [polypeptide binding]; other site 592316002908 OHCU decarboxylase; Region: UraD_2; TIGR03180 592316002909 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 592316002910 active site 592316002911 homotetramer interface [polypeptide binding]; other site 592316002912 C-N hydrolase family amidase; Provisional; Region: PRK10438 592316002913 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 592316002914 putative active site [active] 592316002915 catalytic triad [active] 592316002916 dimer interface [polypeptide binding]; other site 592316002917 multimer interface [polypeptide binding]; other site 592316002918 methionine aminotransferase; Validated; Region: PRK09082 592316002919 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316002920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316002921 homodimer interface [polypeptide binding]; other site 592316002922 catalytic residue [active] 592316002923 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 592316002924 intersubunit interface [polypeptide binding]; other site 592316002925 active site 592316002926 Zn2+ binding site [ion binding]; other site 592316002927 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 592316002928 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 592316002929 Cupin domain; Region: Cupin_2; pfam07883 592316002930 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 592316002931 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 592316002932 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 592316002933 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 592316002934 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 592316002935 active site 592316002936 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 592316002937 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 592316002938 dimer interface [polypeptide binding]; other site 592316002939 active site 592316002940 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 592316002941 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 592316002942 putative active site [active] 592316002943 putative dimer interface [polypeptide binding]; other site 592316002944 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 592316002945 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 592316002946 active site 592316002947 DNA polymerase IV; Validated; Region: PRK02406 592316002948 DNA binding site [nucleotide binding] 592316002949 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 592316002950 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 592316002951 putative ligand binding site [chemical binding]; other site 592316002952 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316002953 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592316002954 TM-ABC transporter signature motif; other site 592316002955 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 592316002956 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 592316002957 Walker A/P-loop; other site 592316002958 ATP binding site [chemical binding]; other site 592316002959 Q-loop/lid; other site 592316002960 ABC transporter signature motif; other site 592316002961 Walker B; other site 592316002962 D-loop; other site 592316002963 H-loop/switch region; other site 592316002964 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 592316002965 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 592316002966 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 592316002967 metal binding site [ion binding]; metal-binding site 592316002968 dimer interface [polypeptide binding]; other site 592316002969 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592316002970 active site 592316002971 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 592316002972 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 592316002973 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 592316002974 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 592316002975 trimer interface [polypeptide binding]; other site 592316002976 eyelet of channel; other site 592316002977 gamma-glutamyl kinase; Provisional; Region: PRK05429 592316002978 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 592316002979 nucleotide binding site [chemical binding]; other site 592316002980 homotetrameric interface [polypeptide binding]; other site 592316002981 putative phosphate binding site [ion binding]; other site 592316002982 putative allosteric binding site; other site 592316002983 PUA domain; Region: PUA; pfam01472 592316002984 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 592316002985 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 592316002986 putative catalytic cysteine [active] 592316002987 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 592316002988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316002989 active site 592316002990 phosphorylation site [posttranslational modification] 592316002991 intermolecular recognition site; other site 592316002992 dimerization interface [polypeptide binding]; other site 592316002993 Transcriptional regulator; Region: CitT; pfam12431 592316002994 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 592316002995 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 592316002996 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592316002997 putative active site [active] 592316002998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316002999 ATP binding site [chemical binding]; other site 592316003000 Mg2+ binding site [ion binding]; other site 592316003001 G-X-G motif; other site 592316003002 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 592316003003 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 592316003004 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 592316003005 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 592316003006 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 592316003007 putative active site [active] 592316003008 (T/H)XGH motif; other site 592316003009 citrate lyase subunit gamma; Provisional; Region: PRK13253 592316003010 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 592316003011 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 592316003012 Coenzyme A transferase; Region: CoA_trans; cl17247 592316003013 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 592316003014 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 592316003015 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 592316003016 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592316003017 active site 592316003018 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 592316003019 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 592316003020 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592316003021 active site 592316003022 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 592316003023 serine transporter; Region: stp; TIGR00814 592316003024 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 592316003025 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592316003026 dimerization interface [polypeptide binding]; other site 592316003027 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592316003028 dimer interface [polypeptide binding]; other site 592316003029 putative CheW interface [polypeptide binding]; other site 592316003030 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 592316003031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316003032 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 592316003033 active site 592316003034 phosphorylation site [posttranslational modification] 592316003035 intermolecular recognition site; other site 592316003036 dimerization interface [polypeptide binding]; other site 592316003037 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 592316003038 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 592316003039 ATP binding site [chemical binding]; other site 592316003040 Mg++ binding site [ion binding]; other site 592316003041 motif III; other site 592316003042 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592316003043 nucleotide binding region [chemical binding]; other site 592316003044 ATP-binding site [chemical binding]; other site 592316003045 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 592316003046 putative deaminase; Validated; Region: PRK06846 592316003047 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 592316003048 active site 592316003049 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316003050 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316003051 dimerization interface [polypeptide binding]; other site 592316003052 putative cyanate transporter; Provisional; Region: cynX; PRK09705 592316003053 L-lactate permease; Provisional; Region: PRK10420 592316003054 glycolate transporter; Provisional; Region: PRK09695 592316003055 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316003056 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 592316003057 DNA-binding site [nucleotide binding]; DNA binding site 592316003058 FCD domain; Region: FCD; pfam07729 592316003059 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 592316003060 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 592316003061 phosphate binding site [ion binding]; other site 592316003062 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 592316003063 CAAX protease self-immunity; Region: Abi; pfam02517 592316003064 CHASE4 domain; Region: CHASE4; pfam05228 592316003065 PAS domain S-box; Region: sensory_box; TIGR00229 592316003066 PAS domain; Region: PAS; smart00091 592316003067 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592316003068 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316003069 metal binding site [ion binding]; metal-binding site 592316003070 active site 592316003071 I-site; other site 592316003072 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592316003073 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 592316003074 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 592316003075 drug efflux system protein MdtG; Provisional; Region: PRK09874 592316003076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316003077 putative substrate translocation pore; other site 592316003078 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 592316003079 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 592316003080 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 592316003081 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 592316003082 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 592316003083 Sigma-S stabilisation anti-adaptor protein; Region: Anti-adapt_IraP; cl11681 592316003084 psiF repeat; Region: PsiF_repeat; pfam07769 592316003085 psiF repeat; Region: PsiF_repeat; pfam07769 592316003086 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 592316003087 iron-sulfur cluster [ion binding]; other site 592316003088 [2Fe-2S] cluster binding site [ion binding]; other site 592316003089 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 592316003090 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592316003091 pyrroline-5-carboxylate reductase; Region: PLN02688 592316003092 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 592316003093 hypothetical protein; Validated; Region: PRK00124 592316003094 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 592316003095 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 592316003096 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 592316003097 ADP binding site [chemical binding]; other site 592316003098 magnesium binding site [ion binding]; other site 592316003099 putative shikimate binding site; other site 592316003100 hypothetical protein; Provisional; Region: PRK10380 592316003101 Transcriptional regulator [Transcription]; Region: IclR; COG1414 592316003102 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592316003103 putative DNA binding site [nucleotide binding]; other site 592316003104 putative Zn2+ binding site [ion binding]; other site 592316003105 Bacterial transcriptional regulator; Region: IclR; pfam01614 592316003106 OPT oligopeptide transporter protein; Region: OPT; cl14607 592316003107 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 592316003108 hypothetical protein; Provisional; Region: PRK10481 592316003109 hypothetical protein; Provisional; Region: PRK10579 592316003110 recombination associated protein; Reviewed; Region: rdgC; PRK00321 592316003111 fructokinase; Reviewed; Region: PRK09557 592316003112 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 592316003113 nucleotide binding site [chemical binding]; other site 592316003114 ethanolamine permease; Region: 2A0305; TIGR00908 592316003115 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 592316003116 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 592316003117 active site 592316003118 substrate binding site [chemical binding]; other site 592316003119 ATP binding site [chemical binding]; other site 592316003120 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 592316003121 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592316003122 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316003123 TolA C-terminal; Region: TolA; pfam06519 592316003124 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 592316003125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 592316003126 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 592316003127 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316003128 AAA domain; Region: AAA_23; pfam13476 592316003129 Walker A/P-loop; other site 592316003130 ATP binding site [chemical binding]; other site 592316003131 Q-loop/lid; other site 592316003132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316003133 ABC transporter signature motif; other site 592316003134 Walker B; other site 592316003135 D-loop; other site 592316003136 H-loop/switch region; other site 592316003137 exonuclease subunit SbcD; Provisional; Region: PRK10966 592316003138 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 592316003139 active site 592316003140 metal binding site [ion binding]; metal-binding site 592316003141 DNA binding site [nucleotide binding] 592316003142 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 592316003143 transcriptional regulator PhoB; Provisional; Region: PRK10161 592316003144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316003145 active site 592316003146 phosphorylation site [posttranslational modification] 592316003147 intermolecular recognition site; other site 592316003148 dimerization interface [polypeptide binding]; other site 592316003149 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592316003150 DNA binding site [nucleotide binding] 592316003151 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 592316003152 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 592316003153 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592316003154 putative active site [active] 592316003155 heme pocket [chemical binding]; other site 592316003156 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316003157 dimer interface [polypeptide binding]; other site 592316003158 phosphorylation site [posttranslational modification] 592316003159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316003160 ATP binding site [chemical binding]; other site 592316003161 Mg2+ binding site [ion binding]; other site 592316003162 G-X-G motif; other site 592316003163 PBP superfamily domain; Region: PBP_like_2; cl17296 592316003164 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 592316003165 substrate binding site [chemical binding]; other site 592316003166 THF binding site; other site 592316003167 zinc-binding site [ion binding]; other site 592316003168 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 592316003169 putative proline-specific permease; Provisional; Region: proY; PRK10580 592316003170 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 592316003171 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 592316003172 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 592316003173 catalytic core [active] 592316003174 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 592316003175 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 592316003176 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 592316003177 active site 592316003178 Protein of unknown function, DUF479; Region: DUF479; cl01203 592316003179 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 592316003180 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 592316003181 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 592316003182 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 592316003183 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 592316003184 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 592316003185 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 592316003186 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 592316003187 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 592316003188 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 592316003189 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 592316003190 Protein export membrane protein; Region: SecD_SecF; pfam02355 592316003191 hypothetical protein; Provisional; Region: PRK11530 592316003192 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 592316003193 ATP cone domain; Region: ATP-cone; pfam03477 592316003194 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 592316003195 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 592316003196 catalytic motif [active] 592316003197 Zn binding site [ion binding]; other site 592316003198 RibD C-terminal domain; Region: RibD_C; cl17279 592316003199 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 592316003200 homopentamer interface [polypeptide binding]; other site 592316003201 active site 592316003202 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 592316003203 putative RNA binding site [nucleotide binding]; other site 592316003204 thiamine monophosphate kinase; Provisional; Region: PRK05731 592316003205 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 592316003206 ATP binding site [chemical binding]; other site 592316003207 dimerization interface [polypeptide binding]; other site 592316003208 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 592316003209 tetramer interfaces [polypeptide binding]; other site 592316003210 binuclear metal-binding site [ion binding]; other site 592316003211 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592316003212 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592316003213 active site 592316003214 catalytic tetrad [active] 592316003215 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 592316003216 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 592316003217 TPP-binding site; other site 592316003218 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 592316003219 PYR/PP interface [polypeptide binding]; other site 592316003220 dimer interface [polypeptide binding]; other site 592316003221 TPP binding site [chemical binding]; other site 592316003222 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 592316003223 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 592316003224 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 592316003225 substrate binding pocket [chemical binding]; other site 592316003226 chain length determination region; other site 592316003227 substrate-Mg2+ binding site; other site 592316003228 catalytic residues [active] 592316003229 aspartate-rich region 1; other site 592316003230 active site lid residues [active] 592316003231 aspartate-rich region 2; other site 592316003232 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 592316003233 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 592316003234 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 592316003235 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 592316003236 Ligand Binding Site [chemical binding]; other site 592316003237 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 592316003238 active site residue [active] 592316003239 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 592316003240 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 592316003241 conserved cys residue [active] 592316003242 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 592316003243 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 592316003244 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 592316003245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 592316003246 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 592316003247 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 592316003248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316003249 Walker A motif; other site 592316003250 ATP binding site [chemical binding]; other site 592316003251 Walker B motif; other site 592316003252 arginine finger; other site 592316003253 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 592316003254 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 592316003255 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 592316003256 NAD(P) binding site [chemical binding]; other site 592316003257 catalytic residues [active] 592316003258 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 592316003259 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 592316003260 NAD binding site [chemical binding]; other site 592316003261 substrate binding site [chemical binding]; other site 592316003262 catalytic Zn binding site [ion binding]; other site 592316003263 tetramer interface [polypeptide binding]; other site 592316003264 structural Zn binding site [ion binding]; other site 592316003265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316003266 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592316003267 putative substrate translocation pore; other site 592316003268 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 592316003269 UbiA prenyltransferase family; Region: UbiA; pfam01040 592316003270 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 592316003271 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 592316003272 Subunit I/III interface [polypeptide binding]; other site 592316003273 Subunit III/IV interface [polypeptide binding]; other site 592316003274 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 592316003275 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 592316003276 D-pathway; other site 592316003277 Putative ubiquinol binding site [chemical binding]; other site 592316003278 Low-spin heme (heme b) binding site [chemical binding]; other site 592316003279 Putative water exit pathway; other site 592316003280 Binuclear center (heme o3/CuB) [ion binding]; other site 592316003281 K-pathway; other site 592316003282 Putative proton exit pathway; other site 592316003283 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 592316003284 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 592316003285 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 592316003286 muropeptide transporter; Reviewed; Region: ampG; PRK11902 592316003287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316003288 putative substrate translocation pore; other site 592316003289 hypothetical protein; Provisional; Region: PRK11627 592316003290 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 592316003291 transcriptional regulator BolA; Provisional; Region: PRK11628 592316003292 trigger factor; Provisional; Region: tig; PRK01490 592316003293 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 592316003294 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 592316003295 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 592316003296 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 592316003297 oligomer interface [polypeptide binding]; other site 592316003298 active site residues [active] 592316003299 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 592316003300 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 592316003301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316003302 Walker A motif; other site 592316003303 ATP binding site [chemical binding]; other site 592316003304 Walker B motif; other site 592316003305 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 592316003306 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 592316003307 Found in ATP-dependent protease La (LON); Region: LON; smart00464 592316003308 Found in ATP-dependent protease La (LON); Region: LON; smart00464 592316003309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316003310 Walker A motif; other site 592316003311 ATP binding site [chemical binding]; other site 592316003312 Walker B motif; other site 592316003313 arginine finger; other site 592316003314 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 592316003315 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 592316003316 IHF dimer interface [polypeptide binding]; other site 592316003317 IHF - DNA interface [nucleotide binding]; other site 592316003318 periplasmic folding chaperone; Provisional; Region: PRK10788 592316003319 SurA N-terminal domain; Region: SurA_N_3; cl07813 592316003320 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 592316003321 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 592316003322 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 592316003323 active site 592316003324 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 592316003325 Ligand Binding Site [chemical binding]; other site 592316003326 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 592316003327 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 592316003328 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 592316003329 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 592316003330 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316003331 active site 592316003332 motif I; other site 592316003333 motif II; other site 592316003334 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 592316003335 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 592316003336 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 592316003337 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592316003338 catalytic residue [active] 592316003339 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 592316003340 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592316003341 dimerization interface [polypeptide binding]; other site 592316003342 putative DNA binding site [nucleotide binding]; other site 592316003343 putative Zn2+ binding site [ion binding]; other site 592316003344 AsnC family; Region: AsnC_trans_reg; pfam01037 592316003345 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 592316003346 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592316003347 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316003348 Walker A/P-loop; other site 592316003349 ATP binding site [chemical binding]; other site 592316003350 Q-loop/lid; other site 592316003351 ABC transporter signature motif; other site 592316003352 Walker B; other site 592316003353 D-loop; other site 592316003354 H-loop/switch region; other site 592316003355 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 592316003356 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592316003357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316003358 Walker A/P-loop; other site 592316003359 ATP binding site [chemical binding]; other site 592316003360 Q-loop/lid; other site 592316003361 ABC transporter signature motif; other site 592316003362 Walker B; other site 592316003363 D-loop; other site 592316003364 H-loop/switch region; other site 592316003365 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 592316003366 Nitrogen regulatory protein P-II; Region: P-II; smart00938 592316003367 ammonium transporter; Provisional; Region: PRK10666 592316003368 acyl-CoA thioesterase II; Provisional; Region: PRK10526 592316003369 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 592316003370 active site 592316003371 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 592316003372 catalytic triad [active] 592316003373 dimer interface [polypeptide binding]; other site 592316003374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 592316003375 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 592316003376 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 592316003377 DNA binding site [nucleotide binding] 592316003378 active site 592316003379 gene expression modulator; Provisional; Region: PRK10945 592316003380 Hha toxicity attenuator; Provisional; Region: PRK10667 592316003381 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 592316003382 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 592316003383 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 592316003384 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 592316003385 ABC-ATPase subunit interface; other site 592316003386 dimer interface [polypeptide binding]; other site 592316003387 putative PBP binding regions; other site 592316003388 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 592316003389 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 592316003390 metal binding site [ion binding]; metal-binding site 592316003391 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 592316003392 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 592316003393 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 592316003394 Protein export membrane protein; Region: SecD_SecF; cl14618 592316003395 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 592316003396 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592316003397 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316003398 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 592316003399 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316003400 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 592316003401 hypothetical protein; Provisional; Region: PRK11038 592316003402 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 592316003403 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 592316003404 hypothetical protein; Provisional; Region: PRK10527 592316003405 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592316003406 active site 592316003407 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 592316003408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316003409 Walker A motif; other site 592316003410 ATP binding site [chemical binding]; other site 592316003411 Walker B motif; other site 592316003412 arginine finger; other site 592316003413 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 592316003414 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 592316003415 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 592316003416 hypothetical protein; Validated; Region: PRK00153 592316003417 recombination protein RecR; Reviewed; Region: recR; PRK00076 592316003418 RecR protein; Region: RecR; pfam02132 592316003419 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 592316003420 putative active site [active] 592316003421 putative metal-binding site [ion binding]; other site 592316003422 tetramer interface [polypeptide binding]; other site 592316003423 heat shock protein 90; Provisional; Region: PRK05218 592316003424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316003425 ATP binding site [chemical binding]; other site 592316003426 Mg2+ binding site [ion binding]; other site 592316003427 G-X-G motif; other site 592316003428 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 592316003429 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 592316003430 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316003431 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 592316003432 dimerization interface [polypeptide binding]; other site 592316003433 substrate binding pocket [chemical binding]; other site 592316003434 adenylate kinase; Reviewed; Region: adk; PRK00279 592316003435 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 592316003436 AMP-binding site [chemical binding]; other site 592316003437 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 592316003438 ferrochelatase; Reviewed; Region: hemH; PRK00035 592316003439 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 592316003440 C-terminal domain interface [polypeptide binding]; other site 592316003441 active site 592316003442 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 592316003443 active site 592316003444 N-terminal domain interface [polypeptide binding]; other site 592316003445 inosine/guanosine kinase; Provisional; Region: PRK15074 592316003446 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592316003447 substrate binding site [chemical binding]; other site 592316003448 ATP binding site [chemical binding]; other site 592316003449 putative cation:proton antiport protein; Provisional; Region: PRK10669 592316003450 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 592316003451 TrkA-N domain; Region: TrkA_N; pfam02254 592316003452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316003453 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592316003454 putative substrate translocation pore; other site 592316003455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316003456 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 592316003457 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 592316003458 active site 592316003459 metal binding site [ion binding]; metal-binding site 592316003460 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 592316003461 Predicted membrane protein [Function unknown]; Region: COG4125 592316003462 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 592316003463 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 592316003464 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316003465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316003466 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592316003467 dimerization interface [polypeptide binding]; other site 592316003468 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 592316003469 putative deacylase active site [active] 592316003470 TraB family; Region: TraB; cl12050 592316003471 copper exporting ATPase; Provisional; Region: copA; PRK10671 592316003472 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 592316003473 metal-binding site [ion binding] 592316003474 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 592316003475 metal-binding site [ion binding] 592316003476 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 592316003477 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316003478 motif II; other site 592316003479 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 592316003480 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 592316003481 DNA binding residues [nucleotide binding] 592316003482 dimer interface [polypeptide binding]; other site 592316003483 copper binding site [ion binding]; other site 592316003484 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 592316003485 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 592316003486 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 592316003487 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 592316003488 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 592316003489 oxidoreductase; Provisional; Region: PRK08017 592316003490 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 592316003491 NADP binding site [chemical binding]; other site 592316003492 active site 592316003493 steroid binding site; other site 592316003494 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 592316003495 active site 592316003496 catalytic triad [active] 592316003497 oxyanion hole [active] 592316003498 switch loop; other site 592316003499 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 592316003500 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 592316003501 Walker A/P-loop; other site 592316003502 ATP binding site [chemical binding]; other site 592316003503 Q-loop/lid; other site 592316003504 ABC transporter signature motif; other site 592316003505 Walker B; other site 592316003506 D-loop; other site 592316003507 H-loop/switch region; other site 592316003508 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 592316003509 FtsX-like permease family; Region: FtsX; pfam02687 592316003510 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 592316003511 ATP-grasp domain; Region: ATP-grasp; pfam02222 592316003512 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 592316003513 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 592316003514 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 592316003515 putative active site [active] 592316003516 putative metal binding site [ion binding]; other site 592316003517 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 592316003518 substrate binding site [chemical binding]; other site 592316003519 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 592316003520 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 592316003521 active site 592316003522 HIGH motif; other site 592316003523 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 592316003524 KMSKS motif; other site 592316003525 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 592316003526 tRNA binding surface [nucleotide binding]; other site 592316003527 anticodon binding site; other site 592316003528 ribosome-associated protein; Provisional; Region: PRK11507 592316003529 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 592316003530 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 592316003531 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 592316003532 homodimer interface [polypeptide binding]; other site 592316003533 NADP binding site [chemical binding]; other site 592316003534 substrate binding site [chemical binding]; other site 592316003535 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 592316003536 integrase; Provisional; Region: PRK09692 592316003537 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 592316003538 active site 592316003539 Int/Topo IB signature motif; other site 592316003540 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 592316003541 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 592316003542 Domain of unknown function (DUF955); Region: DUF955; pfam06114 592316003543 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 592316003544 Part of AAA domain; Region: AAA_19; pfam13245 592316003545 Family description; Region: UvrD_C_2; pfam13538 592316003546 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 592316003547 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 592316003548 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 592316003549 hypothetical protein; Provisional; Region: PRK06153 592316003550 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 592316003551 ATP binding site [chemical binding]; other site 592316003552 substrate interface [chemical binding]; other site 592316003553 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 592316003554 Predicted transcriptional regulator [Transcription]; Region: COG2944 592316003555 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316003556 non-specific DNA binding site [nucleotide binding]; other site 592316003557 salt bridge; other site 592316003558 sequence-specific DNA binding site [nucleotide binding]; other site 592316003559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316003560 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592316003561 putative substrate translocation pore; other site 592316003562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316003563 Transcriptional regulators [Transcription]; Region: FadR; COG2186 592316003564 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316003565 DNA-binding site [nucleotide binding]; DNA binding site 592316003566 FCD domain; Region: FCD; pfam07729 592316003567 cytosine deaminase; Provisional; Region: PRK05985 592316003568 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 592316003569 active site 592316003570 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316003571 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 592316003572 TM-ABC transporter signature motif; other site 592316003573 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 592316003574 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 592316003575 Walker A/P-loop; other site 592316003576 ATP binding site [chemical binding]; other site 592316003577 Q-loop/lid; other site 592316003578 ABC transporter signature motif; other site 592316003579 Walker B; other site 592316003580 D-loop; other site 592316003581 H-loop/switch region; other site 592316003582 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 592316003583 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 592316003584 Walker A/P-loop; other site 592316003585 ATP binding site [chemical binding]; other site 592316003586 Q-loop/lid; other site 592316003587 ABC transporter signature motif; other site 592316003588 Walker B; other site 592316003589 D-loop; other site 592316003590 H-loop/switch region; other site 592316003591 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 592316003592 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316003593 TM-ABC transporter signature motif; other site 592316003594 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 592316003595 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 592316003596 putative ligand binding site [chemical binding]; other site 592316003597 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 592316003598 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 592316003599 intersubunit interface [polypeptide binding]; other site 592316003600 active site 592316003601 zinc binding site [ion binding]; other site 592316003602 Na+ binding site [ion binding]; other site 592316003603 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 592316003604 active site 592316003605 P-loop; other site 592316003606 phosphorylation site [posttranslational modification] 592316003607 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 592316003608 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 592316003609 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 592316003610 active site 592316003611 phosphorylation site [posttranslational modification] 592316003612 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 592316003613 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 592316003614 Mga helix-turn-helix domain; Region: Mga; pfam05043 592316003615 PRD domain; Region: PRD; pfam00874 592316003616 PRD domain; Region: PRD; pfam00874 592316003617 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 592316003618 active site 592316003619 P-loop; other site 592316003620 phosphorylation site [posttranslational modification] 592316003621 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 592316003622 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 592316003623 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 592316003624 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 592316003625 Soluble P-type ATPase [General function prediction only]; Region: COG4087 592316003626 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 592316003627 Domain of unknown function DUF20; Region: UPF0118; pfam01594 592316003628 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 592316003629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 592316003630 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 592316003631 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 592316003632 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 592316003633 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316003634 motif I; other site 592316003635 motif II; other site 592316003636 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 592316003637 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 592316003638 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 592316003639 active site 592316003640 NAD binding site [chemical binding]; other site 592316003641 metal binding site [ion binding]; metal-binding site 592316003642 high-affinity gluconate transporter; Provisional; Region: PRK14984 592316003643 gluconate transporter; Region: gntP; TIGR00791 592316003644 putative dehydrogenase; Provisional; Region: PRK10098 592316003645 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 592316003646 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 592316003647 DNA-binding site [nucleotide binding]; DNA binding site 592316003648 RNA-binding motif; other site 592316003649 putative acetyltransferase; Provisional; Region: PRK03624 592316003650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316003651 Coenzyme A binding pocket [chemical binding]; other site 592316003652 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316003653 DNA-binding site [nucleotide binding]; DNA binding site 592316003654 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 592316003655 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316003656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316003657 homodimer interface [polypeptide binding]; other site 592316003658 catalytic residue [active] 592316003659 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 592316003660 Predicted amidohydrolase [General function prediction only]; Region: COG0388 592316003661 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 592316003662 putative active site [active] 592316003663 catalytic triad [active] 592316003664 putative dimer interface [polypeptide binding]; other site 592316003665 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316003666 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316003667 substrate binding pocket [chemical binding]; other site 592316003668 membrane-bound complex binding site; other site 592316003669 hinge residues; other site 592316003670 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316003671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316003672 dimer interface [polypeptide binding]; other site 592316003673 conserved gate region; other site 592316003674 putative PBP binding loops; other site 592316003675 ABC-ATPase subunit interface; other site 592316003676 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316003677 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316003678 Walker A/P-loop; other site 592316003679 ATP binding site [chemical binding]; other site 592316003680 Q-loop/lid; other site 592316003681 ABC transporter signature motif; other site 592316003682 Walker B; other site 592316003683 D-loop; other site 592316003684 H-loop/switch region; other site 592316003685 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316003686 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 592316003687 lipoyl synthase; Provisional; Region: PRK05481 592316003688 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592316003689 FeS/SAM binding site; other site 592316003690 lipoate-protein ligase B; Provisional; Region: PRK14342 592316003691 hypothetical protein; Provisional; Region: PRK04998 592316003692 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 592316003693 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 592316003694 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 592316003695 rare lipoprotein A; Provisional; Region: PRK10672 592316003696 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 592316003697 Sporulation related domain; Region: SPOR; pfam05036 592316003698 cell wall shape-determining protein; Provisional; Region: PRK10794 592316003699 penicillin-binding protein 2; Provisional; Region: PRK10795 592316003700 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 592316003701 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 592316003702 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 592316003703 ribosome-associated protein; Provisional; Region: PRK11538 592316003704 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 592316003705 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 592316003706 active site 592316003707 (T/H)XGH motif; other site 592316003708 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 592316003709 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 592316003710 Lipopolysaccharide-assembly; Region: LptE; cl01125 592316003711 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 592316003712 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 592316003713 HIGH motif; other site 592316003714 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 592316003715 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592316003716 active site 592316003717 KMSKS motif; other site 592316003718 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 592316003719 tRNA binding surface [nucleotide binding]; other site 592316003720 hypothetical protein; Provisional; Region: PRK11032 592316003721 Predicted integral membrane metal-binding protein (DUF2296); Region: DUF2296; pfam10058 592316003722 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316003723 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316003724 Walker A/P-loop; other site 592316003725 ATP binding site [chemical binding]; other site 592316003726 Q-loop/lid; other site 592316003727 ABC transporter signature motif; other site 592316003728 Walker B; other site 592316003729 D-loop; other site 592316003730 H-loop/switch region; other site 592316003731 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316003732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316003733 dimer interface [polypeptide binding]; other site 592316003734 conserved gate region; other site 592316003735 putative PBP binding loops; other site 592316003736 ABC-ATPase subunit interface; other site 592316003737 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316003738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316003739 dimer interface [polypeptide binding]; other site 592316003740 conserved gate region; other site 592316003741 putative PBP binding loops; other site 592316003742 ABC-ATPase subunit interface; other site 592316003743 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 592316003744 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316003745 substrate binding pocket [chemical binding]; other site 592316003746 membrane-bound complex binding site; other site 592316003747 hinge residues; other site 592316003748 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 592316003749 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 592316003750 putative active site [active] 592316003751 catalytic triad [active] 592316003752 putative dimer interface [polypeptide binding]; other site 592316003753 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 592316003754 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 592316003755 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 592316003756 Transporter associated domain; Region: CorC_HlyC; smart01091 592316003757 metal-binding heat shock protein; Provisional; Region: PRK00016 592316003758 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 592316003759 PhoH-like protein; Region: PhoH; pfam02562 592316003760 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 592316003761 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 592316003762 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592316003763 FeS/SAM binding site; other site 592316003764 TRAM domain; Region: TRAM; pfam01938 592316003765 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 592316003766 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 592316003767 asparagine synthetase B; Provisional; Region: asnB; PRK09431 592316003768 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 592316003769 active site 592316003770 dimer interface [polypeptide binding]; other site 592316003771 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 592316003772 Ligand Binding Site [chemical binding]; other site 592316003773 Molecular Tunnel; other site 592316003774 UMP phosphatase; Provisional; Region: PRK10444 592316003775 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316003776 active site 592316003777 motif I; other site 592316003778 motif II; other site 592316003779 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316003780 MarR family; Region: MarR; pfam01047 592316003781 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 592316003782 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 592316003783 nucleotide binding site [chemical binding]; other site 592316003784 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 592316003785 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 592316003786 active site 592316003787 dimer interface [polypeptide binding]; other site 592316003788 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 592316003789 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 592316003790 active site 592316003791 trimer interface [polypeptide binding]; other site 592316003792 allosteric site; other site 592316003793 active site lid [active] 592316003794 hexamer (dimer of trimers) interface [polypeptide binding]; other site 592316003795 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 592316003796 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 592316003797 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 592316003798 active site turn [active] 592316003799 phosphorylation site [posttranslational modification] 592316003800 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 592316003801 HPr interaction site; other site 592316003802 glycerol kinase (GK) interaction site [polypeptide binding]; other site 592316003803 active site 592316003804 phosphorylation site [posttranslational modification] 592316003805 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 592316003806 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 592316003807 active site 592316003808 HIGH motif; other site 592316003809 nucleotide binding site [chemical binding]; other site 592316003810 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 592316003811 KMSKS motif; other site 592316003812 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 592316003813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 592316003814 ferric uptake regulator; Provisional; Region: fur; PRK09462 592316003815 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 592316003816 metal binding site 2 [ion binding]; metal-binding site 592316003817 putative DNA binding helix; other site 592316003818 metal binding site 1 [ion binding]; metal-binding site 592316003819 dimer interface [polypeptide binding]; other site 592316003820 structural Zn2+ binding site [ion binding]; other site 592316003821 flavodoxin FldA; Validated; Region: PRK09267 592316003822 LexA regulated protein; Provisional; Region: PRK11675 592316003823 acyl-CoA esterase; Provisional; Region: PRK10673 592316003824 PGAP1-like protein; Region: PGAP1; pfam07819 592316003825 replication initiation regulator SeqA; Provisional; Region: PRK11187 592316003826 phosphoglucomutase; Validated; Region: PRK07564 592316003827 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 592316003828 active site 592316003829 substrate binding site [chemical binding]; other site 592316003830 metal binding site [ion binding]; metal-binding site 592316003831 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 592316003832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316003833 active site 592316003834 phosphorylation site [posttranslational modification] 592316003835 intermolecular recognition site; other site 592316003836 dimerization interface [polypeptide binding]; other site 592316003837 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592316003838 DNA binding site [nucleotide binding] 592316003839 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 592316003840 Protein of unknown function (DUF523); Region: DUF523; pfam04463 592316003841 Uncharacterized conserved protein [Function unknown]; Region: COG3272 592316003842 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 592316003843 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 592316003844 DNA photolyase; Region: DNA_photolyase; pfam00875 592316003845 Uncharacterized conserved protein [Function unknown]; Region: COG0327 592316003846 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 592316003847 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 592316003848 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 592316003849 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 592316003850 LamB/YcsF family protein; Provisional; Region: PRK05406 592316003851 Protein of unknown function (DUF969); Region: DUF969; pfam06149 592316003852 Predicted membrane protein [Function unknown]; Region: COG3817 592316003853 Protein of unknown function (DUF979); Region: DUF979; pfam06166 592316003854 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 592316003855 putative substrate binding pocket [chemical binding]; other site 592316003856 AC domain interface; other site 592316003857 catalytic triad [active] 592316003858 AB domain interface; other site 592316003859 interchain disulfide; other site 592316003860 endonuclease VIII; Provisional; Region: PRK10445 592316003861 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 592316003862 DNA binding site [nucleotide binding] 592316003863 catalytic residue [active] 592316003864 putative catalytic residues [active] 592316003865 H2TH interface [polypeptide binding]; other site 592316003866 intercalation triad [nucleotide binding]; other site 592316003867 substrate specificity determining residue; other site 592316003868 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 592316003869 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 592316003870 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 592316003871 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 592316003872 dimer interface [polypeptide binding]; other site 592316003873 active site 592316003874 citrylCoA binding site [chemical binding]; other site 592316003875 NADH binding [chemical binding]; other site 592316003876 cationic pore residues; other site 592316003877 oxalacetate/citrate binding site [chemical binding]; other site 592316003878 coenzyme A binding site [chemical binding]; other site 592316003879 catalytic triad [active] 592316003880 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 592316003881 Iron-sulfur protein interface; other site 592316003882 proximal quinone binding site [chemical binding]; other site 592316003883 SdhD (CybS) interface [polypeptide binding]; other site 592316003884 proximal heme binding site [chemical binding]; other site 592316003885 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 592316003886 cardiolipin binding site; other site 592316003887 SdhC subunit interface [polypeptide binding]; other site 592316003888 proximal heme binding site [chemical binding]; other site 592316003889 Iron-sulfur protein interface; other site 592316003890 proximal quinone binding site [chemical binding]; other site 592316003891 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 592316003892 L-aspartate oxidase; Provisional; Region: PRK06175 592316003893 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 592316003894 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 592316003895 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 592316003896 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 592316003897 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 592316003898 TPP-binding site [chemical binding]; other site 592316003899 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 592316003900 dimer interface [polypeptide binding]; other site 592316003901 PYR/PP interface [polypeptide binding]; other site 592316003902 TPP binding site [chemical binding]; other site 592316003903 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 592316003904 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 592316003905 E3 interaction surface; other site 592316003906 lipoyl attachment site [posttranslational modification]; other site 592316003907 e3 binding domain; Region: E3_binding; pfam02817 592316003908 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 592316003909 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 592316003910 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 592316003911 CoA-ligase; Region: Ligase_CoA; pfam00549 592316003912 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 592316003913 CoA binding domain; Region: CoA_binding; pfam02629 592316003914 CoA-ligase; Region: Ligase_CoA; pfam00549 592316003915 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 592316003916 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 592316003917 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 592316003918 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 592316003919 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 592316003920 hypothetical protein; Provisional; Region: PRK10588 592316003921 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 592316003922 active site 592316003923 colicin uptake protein TolQ; Provisional; Region: PRK10801 592316003924 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 592316003925 colicin uptake protein TolR; Provisional; Region: PRK11024 592316003926 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 592316003927 TolA C-terminal; Region: TolA; pfam06519 592316003928 translocation protein TolB; Provisional; Region: tolB; PRK03629 592316003929 TolB amino-terminal domain; Region: TolB_N; pfam04052 592316003930 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 592316003931 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 592316003932 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 592316003933 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 592316003934 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592316003935 ligand binding site [chemical binding]; other site 592316003936 tol-pal system protein YbgF; Provisional; Region: PRK10803 592316003937 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592316003938 TPR motif; other site 592316003939 binding surface 592316003940 Methyltransferase domain; Region: Methyltransf_24; pfam13578 592316003941 Rhamnan synthesis protein F; Region: RgpF; pfam05045 592316003942 Protein of unknown function (DUF616); Region: DUF616; pfam04765 592316003943 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 592316003944 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 592316003945 Probable Catalytic site; other site 592316003946 metal-binding site 592316003947 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 592316003948 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 592316003949 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316003950 AlkA N-terminal domain; Region: AlkA_N; pfam06029 592316003951 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 592316003952 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 592316003953 minor groove reading motif; other site 592316003954 helix-hairpin-helix signature motif; other site 592316003955 substrate binding pocket [chemical binding]; other site 592316003956 active site 592316003957 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 592316003958 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 592316003959 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 592316003960 DNA binding site [nucleotide binding] 592316003961 active site 592316003962 quinolinate synthetase; Provisional; Region: PRK09375 592316003963 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 592316003964 zinc transporter ZitB; Provisional; Region: PRK03557 592316003965 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 592316003966 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 592316003967 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316003968 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316003969 substrate binding pocket [chemical binding]; other site 592316003970 membrane-bound complex binding site; other site 592316003971 hinge residues; other site 592316003972 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316003973 dimer interface [polypeptide binding]; other site 592316003974 phosphorylation site [posttranslational modification] 592316003975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316003976 ATP binding site [chemical binding]; other site 592316003977 Mg2+ binding site [ion binding]; other site 592316003978 G-X-G motif; other site 592316003979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316003980 active site 592316003981 phosphorylation site [posttranslational modification] 592316003982 intermolecular recognition site; other site 592316003983 Hpt domain; Region: Hpt; pfam01627 592316003984 putative binding surface; other site 592316003985 active site 592316003986 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 592316003987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316003988 active site 592316003989 phosphorylation site [posttranslational modification] 592316003990 intermolecular recognition site; other site 592316003991 dimerization interface [polypeptide binding]; other site 592316003992 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592316003993 DNA binding residues [nucleotide binding] 592316003994 dimerization interface [polypeptide binding]; other site 592316003995 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 592316003996 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 592316003997 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 592316003998 putative active site [active] 592316003999 hypothetical protein; Provisional; Region: PRK07483 592316004000 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592316004001 inhibitor-cofactor binding pocket; inhibition site 592316004002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316004003 catalytic residue [active] 592316004004 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 592316004005 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 592316004006 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316004007 substrate binding pocket [chemical binding]; other site 592316004008 membrane-bound complex binding site; other site 592316004009 hinge residues; other site 592316004010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316004011 dimer interface [polypeptide binding]; other site 592316004012 conserved gate region; other site 592316004013 putative PBP binding loops; other site 592316004014 ABC-ATPase subunit interface; other site 592316004015 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 592316004016 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316004017 Walker A/P-loop; other site 592316004018 ATP binding site [chemical binding]; other site 592316004019 Q-loop/lid; other site 592316004020 ABC transporter signature motif; other site 592316004021 Walker B; other site 592316004022 D-loop; other site 592316004023 H-loop/switch region; other site 592316004024 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 592316004025 YbgS-like protein; Region: YbgS; pfam13985 592316004026 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 592316004027 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 592316004028 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 592316004029 catalytic core [active] 592316004030 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 592316004031 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 592316004032 active site 592316004033 catalytic residues [active] 592316004034 galactokinase; Provisional; Region: PRK05101 592316004035 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 592316004036 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 592316004037 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 592316004038 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 592316004039 dimer interface [polypeptide binding]; other site 592316004040 active site 592316004041 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 592316004042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 592316004043 Walker A/P-loop; other site 592316004044 ATP binding site [chemical binding]; other site 592316004045 Q-loop/lid; other site 592316004046 ABC transporter signature motif; other site 592316004047 Walker B; other site 592316004048 D-loop; other site 592316004049 H-loop/switch region; other site 592316004050 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316004051 Walker A/P-loop; other site 592316004052 ATP binding site [chemical binding]; other site 592316004053 Q-loop/lid; other site 592316004054 ABC transporter signature motif; other site 592316004055 Walker B; other site 592316004056 D-loop; other site 592316004057 H-loop/switch region; other site 592316004058 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 592316004059 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 592316004060 molybdenum-pterin binding domain; Region: Mop; TIGR00638 592316004061 TOBE domain; Region: TOBE; pfam03459 592316004062 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 592316004063 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 592316004064 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 592316004065 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 592316004066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316004067 dimer interface [polypeptide binding]; other site 592316004068 conserved gate region; other site 592316004069 putative PBP binding loops; other site 592316004070 ABC-ATPase subunit interface; other site 592316004071 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 592316004072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316004073 Walker A/P-loop; other site 592316004074 ATP binding site [chemical binding]; other site 592316004075 Q-loop/lid; other site 592316004076 ABC transporter signature motif; other site 592316004077 Walker B; other site 592316004078 D-loop; other site 592316004079 H-loop/switch region; other site 592316004080 molybdenum-pterin binding domain; Region: Mop; TIGR00638 592316004081 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 592316004082 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316004083 active site 592316004084 motif I; other site 592316004085 motif II; other site 592316004086 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 592316004087 6-phosphogluconolactonase; Provisional; Region: PRK11028 592316004088 hypothetical protein; Provisional; Region: PRK09956 592316004089 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 592316004090 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 592316004091 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592316004092 inhibitor-cofactor binding pocket; inhibition site 592316004093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316004094 catalytic residue [active] 592316004095 biotin synthase; Provisional; Region: PRK15108 592316004096 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592316004097 FeS/SAM binding site; other site 592316004098 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 592316004099 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 592316004100 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 592316004101 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592316004102 catalytic residue [active] 592316004103 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 592316004104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316004105 S-adenosylmethionine binding site [chemical binding]; other site 592316004106 AAA domain; Region: AAA_26; pfam13500 592316004107 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 592316004108 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 592316004109 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 592316004110 Walker A/P-loop; other site 592316004111 ATP binding site [chemical binding]; other site 592316004112 Q-loop/lid; other site 592316004113 ABC transporter signature motif; other site 592316004114 Walker B; other site 592316004115 D-loop; other site 592316004116 H-loop/switch region; other site 592316004117 excinuclease ABC subunit B; Provisional; Region: PRK05298 592316004118 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592316004119 ATP binding site [chemical binding]; other site 592316004120 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592316004121 nucleotide binding region [chemical binding]; other site 592316004122 ATP-binding site [chemical binding]; other site 592316004123 Ultra-violet resistance protein B; Region: UvrB; pfam12344 592316004124 UvrB/uvrC motif; Region: UVR; pfam02151 592316004125 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 592316004126 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 592316004127 phosphate binding site [ion binding]; other site 592316004128 putative substrate binding pocket [chemical binding]; other site 592316004129 dimer interface [polypeptide binding]; other site 592316004130 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 592316004131 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592316004132 FeS/SAM binding site; other site 592316004133 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 592316004134 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 592316004135 MPT binding site; other site 592316004136 trimer interface [polypeptide binding]; other site 592316004137 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 592316004138 trimer interface [polypeptide binding]; other site 592316004139 dimer interface [polypeptide binding]; other site 592316004140 putative active site [active] 592316004141 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 592316004142 MoaE interaction surface [polypeptide binding]; other site 592316004143 MoeB interaction surface [polypeptide binding]; other site 592316004144 thiocarboxylated glycine; other site 592316004145 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 592316004146 MoaE homodimer interface [polypeptide binding]; other site 592316004147 MoaD interaction [polypeptide binding]; other site 592316004148 active site residues [active] 592316004149 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 592316004150 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 592316004151 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 592316004152 Predicted integral membrane protein [Function unknown]; Region: COG0392 592316004153 cardiolipin synthase 2; Provisional; Region: PRK11263 592316004154 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 592316004155 putative active site [active] 592316004156 catalytic site [active] 592316004157 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 592316004158 putative active site [active] 592316004159 catalytic site [active] 592316004160 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 592316004161 putative catalytic site [active] 592316004162 putative metal binding site [ion binding]; other site 592316004163 putative phosphate binding site [ion binding]; other site 592316004164 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 592316004165 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 592316004166 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 592316004167 ATP binding site [chemical binding]; other site 592316004168 Mg++ binding site [ion binding]; other site 592316004169 motif III; other site 592316004170 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592316004171 nucleotide binding region [chemical binding]; other site 592316004172 ATP-binding site [chemical binding]; other site 592316004173 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 592316004174 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 592316004175 FMN binding site [chemical binding]; other site 592316004176 active site 592316004177 catalytic residues [active] 592316004178 substrate binding site [chemical binding]; other site 592316004179 major facilitator superfamily transporter; Provisional; Region: PRK05122 592316004180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316004181 putative substrate translocation pore; other site 592316004182 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 592316004183 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 592316004184 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 592316004185 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 592316004186 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 592316004187 Cl binding site [ion binding]; other site 592316004188 oligomer interface [polypeptide binding]; other site 592316004189 L,D-transpeptidase; Provisional; Region: PRK10260 592316004190 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 592316004191 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 592316004192 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 592316004193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316004194 oxidoreductase; Provisional; Region: PRK12743 592316004195 NAD(P) binding site [chemical binding]; other site 592316004196 active site 592316004197 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 592316004198 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 592316004199 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 592316004200 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 592316004201 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 592316004202 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 592316004203 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 592316004204 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592316004205 D-lactate dehydrogenase; Provisional; Region: PRK11183 592316004206 FAD binding domain; Region: FAD_binding_4; pfam01565 592316004207 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 592316004208 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 592316004209 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 592316004210 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 592316004211 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 592316004212 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 592316004213 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 592316004214 dimerization interface [polypeptide binding]; other site 592316004215 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 592316004216 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592316004217 dimer interface [polypeptide binding]; other site 592316004218 putative CheW interface [polypeptide binding]; other site 592316004219 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 592316004220 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 592316004221 active site 592316004222 metal binding site [ion binding]; metal-binding site 592316004223 nudix motif; other site 592316004224 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 592316004225 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 592316004226 trimer interface [polypeptide binding]; other site 592316004227 eyelet of channel; other site 592316004228 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 592316004229 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 592316004230 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 592316004231 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 592316004232 active site 592316004233 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 592316004234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316004235 dimer interface [polypeptide binding]; other site 592316004236 conserved gate region; other site 592316004237 putative PBP binding loops; other site 592316004238 ABC-ATPase subunit interface; other site 592316004239 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 592316004240 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 592316004241 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 592316004242 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 592316004243 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 592316004244 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316004245 Walker A/P-loop; other site 592316004246 ATP binding site [chemical binding]; other site 592316004247 Q-loop/lid; other site 592316004248 ABC transporter signature motif; other site 592316004249 Walker B; other site 592316004250 D-loop; other site 592316004251 H-loop/switch region; other site 592316004252 TOBE domain; Region: TOBE_2; pfam08402 592316004253 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 592316004254 Transcriptional regulators [Transcription]; Region: GntR; COG1802 592316004255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316004256 DNA-binding site [nucleotide binding]; DNA binding site 592316004257 FCD domain; Region: FCD; pfam07729 592316004258 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 592316004259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316004260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316004261 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 592316004262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316004263 dimer interface [polypeptide binding]; other site 592316004264 conserved gate region; other site 592316004265 ABC-ATPase subunit interface; other site 592316004266 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 592316004267 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 592316004268 Walker A/P-loop; other site 592316004269 ATP binding site [chemical binding]; other site 592316004270 Q-loop/lid; other site 592316004271 ABC transporter signature motif; other site 592316004272 Walker B; other site 592316004273 D-loop; other site 592316004274 H-loop/switch region; other site 592316004275 CBS domain; Region: CBS; pfam00571 592316004276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316004277 putative PBP binding loops; other site 592316004278 ABC-ATPase subunit interface; other site 592316004279 transcriptional regulator MirA; Provisional; Region: PRK15043 592316004280 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 592316004281 DNA binding residues [nucleotide binding] 592316004282 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592316004283 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316004284 sequence-specific DNA binding site [nucleotide binding]; other site 592316004285 salt bridge; other site 592316004286 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316004287 Coenzyme A binding pocket [chemical binding]; other site 592316004288 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316004289 Coenzyme A binding pocket [chemical binding]; other site 592316004290 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 592316004291 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316004292 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316004293 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592316004294 dimerization interface [polypeptide binding]; other site 592316004295 argininosuccinate lyase; Provisional; Region: PRK00855 592316004296 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 592316004297 active sites [active] 592316004298 tetramer interface [polypeptide binding]; other site 592316004299 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316004300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316004301 dimer interface [polypeptide binding]; other site 592316004302 conserved gate region; other site 592316004303 putative PBP binding loops; other site 592316004304 ABC-ATPase subunit interface; other site 592316004305 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316004306 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316004307 Walker A/P-loop; other site 592316004308 ATP binding site [chemical binding]; other site 592316004309 Q-loop/lid; other site 592316004310 ABC transporter signature motif; other site 592316004311 Walker B; other site 592316004312 D-loop; other site 592316004313 H-loop/switch region; other site 592316004314 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316004315 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316004316 substrate binding pocket [chemical binding]; other site 592316004317 membrane-bound complex binding site; other site 592316004318 hinge residues; other site 592316004319 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 592316004320 active site 592316004321 catalytic site [active] 592316004322 Zn binding site [ion binding]; other site 592316004323 tetramer interface [polypeptide binding]; other site 592316004324 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 592316004325 active site 592316004326 catalytic site [active] 592316004327 Zn binding site [ion binding]; other site 592316004328 tetramer interface [polypeptide binding]; other site 592316004329 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 592316004330 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 592316004331 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 592316004332 putative active site [active] 592316004333 metal binding site [ion binding]; metal-binding site 592316004334 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 592316004335 agmatinase; Region: agmatinase; TIGR01230 592316004336 oligomer interface [polypeptide binding]; other site 592316004337 putative active site [active] 592316004338 Mn binding site [ion binding]; other site 592316004339 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316004340 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316004341 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592316004342 dimerization interface [polypeptide binding]; other site 592316004343 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 592316004344 DEAD_2; Region: DEAD_2; pfam06733 592316004345 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 592316004346 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 592316004347 glycosyl transferase family protein; Provisional; Region: PRK08136 592316004348 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 592316004349 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 592316004350 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 592316004351 metal binding site [ion binding]; metal-binding site 592316004352 putative dimer interface [polypeptide binding]; other site 592316004353 hypothetical protein; Provisional; Region: PRK09956 592316004354 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 592316004355 urocanate hydratase; Provisional; Region: PRK05414 592316004356 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 592316004357 active sites [active] 592316004358 tetramer interface [polypeptide binding]; other site 592316004359 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 592316004360 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316004361 DNA-binding site [nucleotide binding]; DNA binding site 592316004362 UTRA domain; Region: UTRA; pfam07702 592316004363 HutD; Region: HutD; pfam05962 592316004364 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 592316004365 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 592316004366 active site 592316004367 imidazolonepropionase; Validated; Region: PRK09356 592316004368 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 592316004369 active site 592316004370 N-formylglutamate amidohydrolase; Region: FGase; cl01522 592316004371 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316004372 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316004373 substrate binding pocket [chemical binding]; other site 592316004374 membrane-bound complex binding site; other site 592316004375 hinge residues; other site 592316004376 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316004377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316004378 dimer interface [polypeptide binding]; other site 592316004379 conserved gate region; other site 592316004380 putative PBP binding loops; other site 592316004381 ABC-ATPase subunit interface; other site 592316004382 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316004383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316004384 dimer interface [polypeptide binding]; other site 592316004385 conserved gate region; other site 592316004386 putative PBP binding loops; other site 592316004387 ABC-ATPase subunit interface; other site 592316004388 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 592316004389 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316004390 Walker A/P-loop; other site 592316004391 ATP binding site [chemical binding]; other site 592316004392 Q-loop/lid; other site 592316004393 ABC transporter signature motif; other site 592316004394 Walker B; other site 592316004395 D-loop; other site 592316004396 H-loop/switch region; other site 592316004397 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 592316004398 active sites [active] 592316004399 tetramer interface [polypeptide binding]; other site 592316004400 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 592316004401 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 592316004402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316004403 S-adenosylmethionine binding site [chemical binding]; other site 592316004404 putative mechanosensitive channel protein; Provisional; Region: PRK11465 592316004405 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592316004406 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 592316004407 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316004408 Walker A/P-loop; other site 592316004409 ATP binding site [chemical binding]; other site 592316004410 Q-loop/lid; other site 592316004411 ABC transporter signature motif; other site 592316004412 Walker B; other site 592316004413 D-loop; other site 592316004414 H-loop/switch region; other site 592316004415 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316004416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316004417 dimer interface [polypeptide binding]; other site 592316004418 conserved gate region; other site 592316004419 putative PBP binding loops; other site 592316004420 ABC-ATPase subunit interface; other site 592316004421 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 592316004422 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316004423 substrate binding pocket [chemical binding]; other site 592316004424 membrane-bound complex binding site; other site 592316004425 hinge residues; other site 592316004426 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 592316004427 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 592316004428 dimerization interface [polypeptide binding]; other site 592316004429 DPS ferroxidase diiron center [ion binding]; other site 592316004430 ion pore; other site 592316004431 threonine and homoserine efflux system; Provisional; Region: PRK10532 592316004432 EamA-like transporter family; Region: EamA; pfam00892 592316004433 outer membrane protein X; Provisional; Region: ompX; PRK09408 592316004434 manganese transport regulator MntR; Provisional; Region: PRK11050 592316004435 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 592316004436 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 592316004437 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 592316004438 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 592316004439 transmembrane helices; other site 592316004440 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 592316004441 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592316004442 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316004443 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 592316004444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316004445 putative substrate translocation pore; other site 592316004446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316004447 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 592316004448 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 592316004449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316004450 putative substrate translocation pore; other site 592316004451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316004452 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 592316004453 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 592316004454 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 592316004455 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592316004456 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316004457 Walker A/P-loop; other site 592316004458 ATP binding site [chemical binding]; other site 592316004459 ABC transporter signature motif; other site 592316004460 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592316004461 Walker B; other site 592316004462 ABC transporter; Region: ABC_tran_2; pfam12848 592316004463 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592316004464 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 592316004465 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 592316004466 ATP binding site [chemical binding]; other site 592316004467 substrate interface [chemical binding]; other site 592316004468 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 592316004469 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 592316004470 dimer interface [polypeptide binding]; other site 592316004471 putative functional site; other site 592316004472 putative MPT binding site; other site 592316004473 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 592316004474 Ligand Binding Site [chemical binding]; other site 592316004475 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 592316004476 catalytic nucleophile [active] 592316004477 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 592316004478 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316004479 Walker A/P-loop; other site 592316004480 ATP binding site [chemical binding]; other site 592316004481 Q-loop/lid; other site 592316004482 ABC transporter signature motif; other site 592316004483 Walker B; other site 592316004484 D-loop; other site 592316004485 H-loop/switch region; other site 592316004486 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316004487 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316004488 Walker A/P-loop; other site 592316004489 ATP binding site [chemical binding]; other site 592316004490 Q-loop/lid; other site 592316004491 ABC transporter signature motif; other site 592316004492 Walker B; other site 592316004493 D-loop; other site 592316004494 H-loop/switch region; other site 592316004495 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316004496 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 592316004497 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 592316004498 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 592316004499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316004500 dimer interface [polypeptide binding]; other site 592316004501 conserved gate region; other site 592316004502 putative PBP binding loops; other site 592316004503 ABC-ATPase subunit interface; other site 592316004504 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 592316004505 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 592316004506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316004507 dimer interface [polypeptide binding]; other site 592316004508 conserved gate region; other site 592316004509 putative PBP binding loops; other site 592316004510 ABC-ATPase subunit interface; other site 592316004511 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 592316004512 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 592316004513 dimer interface [polypeptide binding]; other site 592316004514 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592316004515 dimerization interface [polypeptide binding]; other site 592316004516 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592316004517 dimer interface [polypeptide binding]; other site 592316004518 putative CheW interface [polypeptide binding]; other site 592316004519 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 592316004520 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 592316004521 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592316004522 FeS/SAM binding site; other site 592316004523 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 592316004524 active site clefts [active] 592316004525 zinc binding site [ion binding]; other site 592316004526 dimer interface [polypeptide binding]; other site 592316004527 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 592316004528 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 592316004529 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 592316004530 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 592316004531 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 592316004532 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 592316004533 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 592316004534 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 592316004535 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 592316004536 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 592316004537 active site 592316004538 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 592316004539 active site 592316004540 putative transporter; Provisional; Region: PRK04972 592316004541 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 592316004542 TrkA-C domain; Region: TrkA_C; pfam02080 592316004543 TrkA-C domain; Region: TrkA_C; pfam02080 592316004544 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 592316004545 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 592316004546 GSH binding site [chemical binding]; other site 592316004547 catalytic residues [active] 592316004548 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 592316004549 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 592316004550 conserved cys residue [active] 592316004551 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316004552 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316004553 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 592316004554 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 592316004555 hypothetical protein; Provisional; Region: PRK10591 592316004556 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 592316004557 dimer interface [polypeptide binding]; other site 592316004558 FMN binding site [chemical binding]; other site 592316004559 NADPH bind site [chemical binding]; other site 592316004560 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 592316004561 RimK-like ATP-grasp domain; Region: RimK; pfam08443 592316004562 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 592316004563 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 592316004564 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 592316004565 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 592316004566 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 592316004567 Walker A/P-loop; other site 592316004568 ATP binding site [chemical binding]; other site 592316004569 Q-loop/lid; other site 592316004570 ABC transporter signature motif; other site 592316004571 Walker B; other site 592316004572 D-loop; other site 592316004573 H-loop/switch region; other site 592316004574 TOBE domain; Region: TOBE_2; pfam08402 592316004575 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 592316004576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316004577 dimer interface [polypeptide binding]; other site 592316004578 conserved gate region; other site 592316004579 putative PBP binding loops; other site 592316004580 ABC-ATPase subunit interface; other site 592316004581 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 592316004582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316004583 dimer interface [polypeptide binding]; other site 592316004584 conserved gate region; other site 592316004585 putative PBP binding loops; other site 592316004586 ABC-ATPase subunit interface; other site 592316004587 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 592316004588 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 592316004589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316004590 S-adenosylmethionine binding site [chemical binding]; other site 592316004591 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 592316004592 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316004593 substrate binding pocket [chemical binding]; other site 592316004594 membrane-bound complex binding site; other site 592316004595 hinge residues; other site 592316004596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316004597 dimer interface [polypeptide binding]; other site 592316004598 conserved gate region; other site 592316004599 putative PBP binding loops; other site 592316004600 ABC-ATPase subunit interface; other site 592316004601 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316004602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316004603 dimer interface [polypeptide binding]; other site 592316004604 conserved gate region; other site 592316004605 putative PBP binding loops; other site 592316004606 ABC-ATPase subunit interface; other site 592316004607 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 592316004608 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316004609 substrate binding pocket [chemical binding]; other site 592316004610 membrane-bound complex binding site; other site 592316004611 hinge residues; other site 592316004612 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 592316004613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316004614 Walker A/P-loop; other site 592316004615 ATP binding site [chemical binding]; other site 592316004616 Q-loop/lid; other site 592316004617 ABC transporter signature motif; other site 592316004618 Walker B; other site 592316004619 D-loop; other site 592316004620 H-loop/switch region; other site 592316004621 putative lipoprotein; Provisional; Region: PRK10533 592316004622 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 592316004623 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 592316004624 amidase catalytic site [active] 592316004625 Zn binding residues [ion binding]; other site 592316004626 substrate binding site [chemical binding]; other site 592316004627 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 592316004628 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 592316004629 tetramer interface [polypeptide binding]; other site 592316004630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316004631 catalytic residue [active] 592316004632 pyruvate dehydrogenase; Provisional; Region: PRK09124 592316004633 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 592316004634 PYR/PP interface [polypeptide binding]; other site 592316004635 dimer interface [polypeptide binding]; other site 592316004636 tetramer interface [polypeptide binding]; other site 592316004637 TPP binding site [chemical binding]; other site 592316004638 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 592316004639 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 592316004640 TPP-binding site [chemical binding]; other site 592316004641 Predicted membrane protein [Function unknown]; Region: COG2431 592316004642 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 592316004643 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 592316004644 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 592316004645 putative active site [active] 592316004646 putative metal-binding site [ion binding]; other site 592316004647 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 592316004648 DNA-binding site [nucleotide binding]; DNA binding site 592316004649 RNA-binding motif; other site 592316004650 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 592316004651 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 592316004652 Clp amino terminal domain; Region: Clp_N; pfam02861 592316004653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316004654 Walker A motif; other site 592316004655 ATP binding site [chemical binding]; other site 592316004656 Walker B motif; other site 592316004657 arginine finger; other site 592316004658 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316004659 Walker A motif; other site 592316004660 ATP binding site [chemical binding]; other site 592316004661 Walker B motif; other site 592316004662 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 592316004663 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 592316004664 rRNA binding site [nucleotide binding]; other site 592316004665 predicted 30S ribosome binding site; other site 592316004666 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 592316004667 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 592316004668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316004669 Walker A/P-loop; other site 592316004670 ATP binding site [chemical binding]; other site 592316004671 Q-loop/lid; other site 592316004672 ABC transporter signature motif; other site 592316004673 Walker B; other site 592316004674 D-loop; other site 592316004675 H-loop/switch region; other site 592316004676 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 592316004677 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592316004678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316004679 Walker A/P-loop; other site 592316004680 ATP binding site [chemical binding]; other site 592316004681 Q-loop/lid; other site 592316004682 ABC transporter signature motif; other site 592316004683 Walker B; other site 592316004684 D-loop; other site 592316004685 H-loop/switch region; other site 592316004686 thioredoxin reductase; Provisional; Region: PRK10262 592316004687 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592316004688 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592316004689 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 592316004690 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592316004691 putative DNA binding site [nucleotide binding]; other site 592316004692 putative Zn2+ binding site [ion binding]; other site 592316004693 AsnC family; Region: AsnC_trans_reg; pfam01037 592316004694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316004695 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 592316004696 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 592316004697 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 592316004698 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 592316004699 recombination factor protein RarA; Reviewed; Region: PRK13342 592316004700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316004701 Walker A motif; other site 592316004702 ATP binding site [chemical binding]; other site 592316004703 Walker B motif; other site 592316004704 arginine finger; other site 592316004705 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 592316004706 seryl-tRNA synthetase; Provisional; Region: PRK05431 592316004707 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 592316004708 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 592316004709 dimer interface [polypeptide binding]; other site 592316004710 active site 592316004711 motif 1; other site 592316004712 motif 2; other site 592316004713 motif 3; other site 592316004714 putative MFS family transporter protein; Provisional; Region: PRK03633 592316004715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316004716 putative substrate translocation pore; other site 592316004717 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 592316004718 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592316004719 FeS/SAM binding site; other site 592316004720 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 592316004721 Pyruvate formate lyase 1; Region: PFL1; cd01678 592316004722 coenzyme A binding site [chemical binding]; other site 592316004723 active site 592316004724 catalytic residues [active] 592316004725 glycine loop; other site 592316004726 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 592316004727 uncharacterized domain; Region: TIGR00702 592316004728 YcaO-like family; Region: YcaO; pfam02624 592316004729 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 592316004730 homodimer interface [polypeptide binding]; other site 592316004731 substrate-cofactor binding pocket; other site 592316004732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316004733 catalytic residue [active] 592316004734 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 592316004735 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 592316004736 hinge; other site 592316004737 active site 592316004738 cytidylate kinase; Provisional; Region: cmk; PRK00023 592316004739 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 592316004740 CMP-binding site; other site 592316004741 The sites determining sugar specificity; other site 592316004742 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 592316004743 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 592316004744 RNA binding site [nucleotide binding]; other site 592316004745 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 592316004746 RNA binding site [nucleotide binding]; other site 592316004747 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 592316004748 RNA binding site [nucleotide binding]; other site 592316004749 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 592316004750 RNA binding site [nucleotide binding]; other site 592316004751 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 592316004752 RNA binding site [nucleotide binding]; other site 592316004753 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 592316004754 IHF dimer interface [polypeptide binding]; other site 592316004755 IHF - DNA interface [nucleotide binding]; other site 592316004756 ComEC family competence protein; Provisional; Region: PRK11539 592316004757 Competence protein; Region: Competence; pfam03772 592316004758 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 592316004759 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 592316004760 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592316004761 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 592316004762 Walker A/P-loop; other site 592316004763 ATP binding site [chemical binding]; other site 592316004764 Q-loop/lid; other site 592316004765 ABC transporter signature motif; other site 592316004766 Walker B; other site 592316004767 D-loop; other site 592316004768 H-loop/switch region; other site 592316004769 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 592316004770 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 592316004771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 592316004772 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 592316004773 Trm112p-like protein; Region: Trm112p; cl01066 592316004774 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 592316004775 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 592316004776 Ligand binding site; other site 592316004777 oligomer interface; other site 592316004778 hypothetical protein; Provisional; Region: PRK10593 592316004779 Uncharacterized conserved protein [Function unknown]; Region: COG1434 592316004780 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 592316004781 putative active site [active] 592316004782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316004783 S-adenosylmethionine binding site [chemical binding]; other site 592316004784 condesin subunit F; Provisional; Region: PRK05260 592316004785 condesin subunit E; Provisional; Region: PRK05256 592316004786 cell division protein MukB; Provisional; Region: mukB; PRK04863 592316004787 P-loop containing region of AAA domain; Region: AAA_29; cl17516 592316004788 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 592316004789 murein L,D-transpeptidase; Provisional; Region: PRK10594 592316004790 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 592316004791 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 592316004792 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 592316004793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 592316004794 Peptidase M15; Region: Peptidase_M15_3; cl01194 592316004795 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 592316004796 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 592316004797 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316004798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316004799 homodimer interface [polypeptide binding]; other site 592316004800 catalytic residue [active] 592316004801 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 592316004802 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 592316004803 trimer interface [polypeptide binding]; other site 592316004804 eyelet of channel; other site 592316004805 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 592316004806 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 592316004807 putative dimer interface [polypeptide binding]; other site 592316004808 putative anticodon binding site; other site 592316004809 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 592316004810 homodimer interface [polypeptide binding]; other site 592316004811 motif 1; other site 592316004812 motif 2; other site 592316004813 active site 592316004814 motif 3; other site 592316004815 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 592316004816 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 592316004817 active site 592316004818 aminopeptidase N; Provisional; Region: pepN; PRK14015 592316004819 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 592316004820 active site 592316004821 Zn binding site [ion binding]; other site 592316004822 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 592316004823 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 592316004824 Walker A/P-loop; other site 592316004825 ATP binding site [chemical binding]; other site 592316004826 Q-loop/lid; other site 592316004827 ABC transporter signature motif; other site 592316004828 Walker B; other site 592316004829 D-loop; other site 592316004830 H-loop/switch region; other site 592316004831 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 592316004832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316004833 dimer interface [polypeptide binding]; other site 592316004834 conserved gate region; other site 592316004835 putative PBP binding loops; other site 592316004836 ABC-ATPase subunit interface; other site 592316004837 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 592316004838 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 592316004839 active site 592316004840 dimer interface [polypeptide binding]; other site 592316004841 non-prolyl cis peptide bond; other site 592316004842 insertion regions; other site 592316004843 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316004844 substrate binding pocket [chemical binding]; other site 592316004845 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 592316004846 membrane-bound complex binding site; other site 592316004847 hinge residues; other site 592316004848 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 592316004849 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592316004850 putative glycosyl transferase; Provisional; Region: PRK10073 592316004851 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592316004852 active site 592316004853 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 592316004854 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 592316004855 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 592316004856 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 592316004857 quinone interaction residues [chemical binding]; other site 592316004858 active site 592316004859 catalytic residues [active] 592316004860 FMN binding site [chemical binding]; other site 592316004861 substrate binding site [chemical binding]; other site 592316004862 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 592316004863 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 592316004864 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 592316004865 MOSC domain; Region: MOSC; pfam03473 592316004866 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 592316004867 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 592316004868 catalytic loop [active] 592316004869 iron binding site [ion binding]; other site 592316004870 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 592316004871 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 592316004872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 592316004873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316004874 S-adenosylmethionine binding site [chemical binding]; other site 592316004875 ABC transporter ATPase component; Reviewed; Region: PRK11147 592316004876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316004877 Walker A/P-loop; other site 592316004878 ATP binding site [chemical binding]; other site 592316004879 ABC transporter signature motif; other site 592316004880 Walker B; other site 592316004881 D-loop; other site 592316004882 H-loop/switch region; other site 592316004883 ABC transporter; Region: ABC_tran_2; pfam12848 592316004884 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592316004885 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 592316004886 Paraquat-inducible protein A; Region: PqiA; pfam04403 592316004887 Paraquat-inducible protein A; Region: PqiA; pfam04403 592316004888 paraquat-inducible protein B; Provisional; Region: PRK10807 592316004889 mce related protein; Region: MCE; pfam02470 592316004890 mce related protein; Region: MCE; pfam02470 592316004891 mce related protein; Region: MCE; pfam02470 592316004892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 592316004893 Protein of unknown function (DUF330); Region: DUF330; pfam03886 592316004894 Ribosome modulation factor; Region: RMF; pfam04957 592316004895 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 592316004896 active site 1 [active] 592316004897 dimer interface [polypeptide binding]; other site 592316004898 active site 2 [active] 592316004899 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 592316004900 DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers; Region: NR_DBD_like; cl02596 592316004901 DNA binding site [nucleotide binding] 592316004902 zinc binding site [ion binding]; other site 592316004903 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 592316004904 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 592316004905 outer membrane protein A; Reviewed; Region: PRK10808 592316004906 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 592316004907 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592316004908 ligand binding site [chemical binding]; other site 592316004909 Cell division inhibitor SulA; Region: SulA; cl01880 592316004910 TfoX N-terminal domain; Region: TfoX_N; pfam04993 592316004911 TfoX C-terminal domain; Region: TfoX_C; pfam04994 592316004912 TIGR01666 family membrane protein; Region: YCCS 592316004913 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 592316004914 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 592316004915 hypothetical protein; Provisional; Region: PRK11770 592316004916 Domain of unknown function (DUF307); Region: DUF307; pfam03733 592316004917 Domain of unknown function (DUF307); Region: DUF307; pfam03733 592316004918 DNA helicase IV; Provisional; Region: helD; PRK11054 592316004919 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 592316004920 Part of AAA domain; Region: AAA_19; pfam13245 592316004921 Family description; Region: UvrD_C_2; pfam13538 592316004922 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 592316004923 active site 592316004924 dimer interfaces [polypeptide binding]; other site 592316004925 catalytic residues [active] 592316004926 hypothetical protein; Provisional; Region: PRK03641 592316004927 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 592316004928 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 592316004929 heat shock protein HspQ; Provisional; Region: PRK14129 592316004930 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 592316004931 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 592316004932 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 592316004933 putative RNA binding site [nucleotide binding]; other site 592316004934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316004935 S-adenosylmethionine binding site [chemical binding]; other site 592316004936 acylphosphatase; Provisional; Region: PRK14426 592316004937 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 592316004938 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 592316004939 YccA-like proteins; Region: YccA_like; cd10433 592316004940 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 592316004941 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 592316004942 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 592316004943 catalytic core [active] 592316004944 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 592316004945 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 592316004946 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 592316004947 NAD(P) binding site [chemical binding]; other site 592316004948 catalytic residues [active] 592316004949 hypothetical protein; Provisional; Region: PRK10174 592316004950 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 592316004951 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592316004952 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 592316004953 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 592316004954 pyrimidine utilization protein D; Region: RutD; TIGR03611 592316004955 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 592316004956 homotrimer interaction site [polypeptide binding]; other site 592316004957 putative active site [active] 592316004958 Isochorismatase family; Region: Isochorismatase; pfam00857 592316004959 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 592316004960 catalytic triad [active] 592316004961 conserved cis-peptide bond; other site 592316004962 pyrimidine utilization protein A; Region: RutA; TIGR03612 592316004963 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 592316004964 active site 592316004965 dimer interface [polypeptide binding]; other site 592316004966 non-prolyl cis peptide bond; other site 592316004967 insertion regions; other site 592316004968 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 592316004969 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316004970 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 592316004971 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 592316004972 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 592316004973 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 592316004974 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 592316004975 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 592316004976 Autoinducer binding domain; Region: Autoind_bind; pfam03472 592316004977 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592316004978 DNA binding residues [nucleotide binding] 592316004979 dimerization interface [polypeptide binding]; other site 592316004980 Autoinducer synthetase; Region: Autoind_synth; cl17404 592316004981 hypothetical protein; Provisional; Region: PRK10613 592316004982 response regulator; Provisional; Region: PRK09483 592316004983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316004984 active site 592316004985 phosphorylation site [posttranslational modification] 592316004986 intermolecular recognition site; other site 592316004987 dimerization interface [polypeptide binding]; other site 592316004988 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592316004989 DNA binding residues [nucleotide binding] 592316004990 dimerization interface [polypeptide binding]; other site 592316004991 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 592316004992 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 592316004993 GIY-YIG motif/motif A; other site 592316004994 active site 592316004995 catalytic site [active] 592316004996 putative DNA binding site [nucleotide binding]; other site 592316004997 metal binding site [ion binding]; metal-binding site 592316004998 UvrB/uvrC motif; Region: UVR; pfam02151 592316004999 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 592316005000 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 592316005001 negative regulator GrlR; Provisional; Region: PRK14051 592316005002 Phage terminase, small subunit; Region: Terminase_4; cl01525 592316005003 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 592316005004 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 592316005005 YcfA-like protein; Region: YcfA; pfam07927 592316005006 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 592316005007 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 592316005008 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592316005009 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316005010 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 592316005011 putative active site [active] 592316005012 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 592316005013 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592316005014 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 592316005015 Walker A/P-loop; other site 592316005016 ATP binding site [chemical binding]; other site 592316005017 Q-loop/lid; other site 592316005018 ABC transporter signature motif; other site 592316005019 Walker B; other site 592316005020 D-loop; other site 592316005021 H-loop/switch region; other site 592316005022 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316005023 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 592316005024 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316005025 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316005026 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316005027 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 592316005028 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316005029 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316005030 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 592316005031 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316005032 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 592316005033 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316005034 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316005035 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316005036 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 592316005037 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 592316005038 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 592316005039 high affinity sulphate transporter 1; Region: sulP; TIGR00815 592316005040 Sulfate transporter family; Region: Sulfate_transp; pfam00916 592316005041 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 592316005042 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 592316005043 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 592316005044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316005045 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 592316005046 putative substrate translocation pore; other site 592316005047 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 592316005048 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592316005049 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316005050 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 592316005051 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 592316005052 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316005053 N-terminal plug; other site 592316005054 ligand-binding site [chemical binding]; other site 592316005055 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 592316005056 PLD-like domain; Region: PLDc_2; pfam13091 592316005057 putative active site [active] 592316005058 catalytic site [active] 592316005059 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 592316005060 PLD-like domain; Region: PLDc_2; pfam13091 592316005061 putative active site [active] 592316005062 catalytic site [active] 592316005063 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 592316005064 Acyltransferase family; Region: Acyl_transf_3; pfam01757 592316005065 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 592316005066 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 592316005067 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 592316005068 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 592316005069 Ligand binding site; other site 592316005070 DXD motif; other site 592316005071 lipoprotein; Provisional; Region: PRK10175 592316005072 secY/secA suppressor protein; Provisional; Region: PRK11467 592316005073 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 592316005074 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 592316005075 putative acyl-acceptor binding pocket; other site 592316005076 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 592316005077 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 592316005078 active site residue [active] 592316005079 hypothetical protein; Provisional; Region: PRK03757 592316005080 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 592316005081 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 592316005082 hydroxyglutarate oxidase; Provisional; Region: PRK11728 592316005083 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 592316005084 DNA damage-inducible protein I; Provisional; Region: PRK10597 592316005085 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 592316005086 active site 592316005087 substrate binding pocket [chemical binding]; other site 592316005088 dimer interface [polypeptide binding]; other site 592316005089 lipoprotein; Provisional; Region: PRK10598 592316005090 glutaredoxin 2; Provisional; Region: PRK10387 592316005091 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 592316005092 C-terminal domain interface [polypeptide binding]; other site 592316005093 GSH binding site (G-site) [chemical binding]; other site 592316005094 catalytic residues [active] 592316005095 putative dimer interface [polypeptide binding]; other site 592316005096 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 592316005097 N-terminal domain interface [polypeptide binding]; other site 592316005098 multidrug resistance protein MdtH; Provisional; Region: PRK11646 592316005099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316005100 putative substrate translocation pore; other site 592316005101 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 592316005102 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 592316005103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 592316005104 hypothetical protein; Provisional; Region: PRK11239 592316005105 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592316005106 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592316005107 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592316005108 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 592316005109 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 592316005110 FlgN protein; Region: FlgN; cl09176 592316005111 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 592316005112 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 592316005113 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 592316005114 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 592316005115 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 592316005116 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 592316005117 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 592316005118 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 592316005119 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 592316005120 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 592316005121 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 592316005122 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 592316005123 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 592316005124 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 592316005125 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 592316005126 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 592316005127 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 592316005128 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 592316005129 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 592316005130 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 592316005131 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 592316005132 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 592316005133 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 592316005134 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 592316005135 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 592316005136 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 592316005137 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 592316005138 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 592316005139 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 592316005140 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 592316005141 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 592316005142 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 592316005143 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 592316005144 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 592316005145 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 592316005146 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 592316005147 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 592316005148 homodimer interface [polypeptide binding]; other site 592316005149 oligonucleotide binding site [chemical binding]; other site 592316005150 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 592316005151 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 592316005152 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592316005153 RNA binding surface [nucleotide binding]; other site 592316005154 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 592316005155 active site 592316005156 Maf-like protein; Region: Maf; pfam02545 592316005157 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 592316005158 active site 592316005159 dimer interface [polypeptide binding]; other site 592316005160 hypothetical protein; Provisional; Region: PRK11193 592316005161 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 592316005162 putative phosphate acyltransferase; Provisional; Region: PRK05331 592316005163 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 592316005164 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 592316005165 dimer interface [polypeptide binding]; other site 592316005166 active site 592316005167 CoA binding pocket [chemical binding]; other site 592316005168 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 592316005169 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 592316005170 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 592316005171 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 592316005172 NAD(P) binding site [chemical binding]; other site 592316005173 homotetramer interface [polypeptide binding]; other site 592316005174 homodimer interface [polypeptide binding]; other site 592316005175 active site 592316005176 acyl carrier protein; Provisional; Region: acpP; PRK00982 592316005177 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 592316005178 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 592316005179 dimer interface [polypeptide binding]; other site 592316005180 active site 592316005181 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 592316005182 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 592316005183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316005184 catalytic residue [active] 592316005185 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 592316005186 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 592316005187 dimerization interface [polypeptide binding]; other site 592316005188 thymidylate kinase; Validated; Region: tmk; PRK00698 592316005189 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 592316005190 TMP-binding site; other site 592316005191 ATP-binding site [chemical binding]; other site 592316005192 DNA polymerase III subunit delta'; Validated; Region: PRK07993 592316005193 DNA polymerase III subunit delta'; Validated; Region: PRK08485 592316005194 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 592316005195 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 592316005196 active site 592316005197 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 592316005198 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 592316005199 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 592316005200 active site turn [active] 592316005201 phosphorylation site [posttranslational modification] 592316005202 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 592316005203 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 592316005204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316005205 putative substrate translocation pore; other site 592316005206 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 592316005207 nucleotide binding site/active site [active] 592316005208 HIT family signature motif; other site 592316005209 catalytic residue [active] 592316005210 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 592316005211 putative dimer interface [polypeptide binding]; other site 592316005212 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 592316005213 thiamine kinase; Region: ycfN_thiK; TIGR02721 592316005214 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 592316005215 active site 592316005216 substrate binding site [chemical binding]; other site 592316005217 ATP binding site [chemical binding]; other site 592316005218 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 592316005219 beta-hexosaminidase; Provisional; Region: PRK05337 592316005220 hypothetical protein; Provisional; Region: PRK04940 592316005221 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 592316005222 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592316005223 hypothetical protein; Provisional; Region: PRK11280 592316005224 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 592316005225 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 592316005226 putative active site [active] 592316005227 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592316005228 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 592316005229 Walker A/P-loop; other site 592316005230 ATP binding site [chemical binding]; other site 592316005231 Q-loop/lid; other site 592316005232 ABC transporter signature motif; other site 592316005233 Walker B; other site 592316005234 D-loop; other site 592316005235 H-loop/switch region; other site 592316005236 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 592316005237 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316005238 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316005239 transcription-repair coupling factor; Provisional; Region: PRK10689 592316005240 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 592316005241 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592316005242 ATP binding site [chemical binding]; other site 592316005243 putative Mg++ binding site [ion binding]; other site 592316005244 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592316005245 nucleotide binding region [chemical binding]; other site 592316005246 ATP-binding site [chemical binding]; other site 592316005247 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 592316005248 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 592316005249 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592316005250 FtsX-like permease family; Region: FtsX; pfam02687 592316005251 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 592316005252 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 592316005253 Walker A/P-loop; other site 592316005254 ATP binding site [chemical binding]; other site 592316005255 Q-loop/lid; other site 592316005256 ABC transporter signature motif; other site 592316005257 Walker B; other site 592316005258 D-loop; other site 592316005259 H-loop/switch region; other site 592316005260 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 592316005261 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592316005262 FtsX-like permease family; Region: FtsX; pfam02687 592316005263 NAD-dependent deacetylase; Provisional; Region: PRK00481 592316005264 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 592316005265 NAD+ binding site [chemical binding]; other site 592316005266 substrate binding site [chemical binding]; other site 592316005267 Zn binding site [ion binding]; other site 592316005268 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 592316005269 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 592316005270 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 592316005271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316005272 dimer interface [polypeptide binding]; other site 592316005273 conserved gate region; other site 592316005274 putative PBP binding loops; other site 592316005275 ABC-ATPase subunit interface; other site 592316005276 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 592316005277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316005278 dimer interface [polypeptide binding]; other site 592316005279 conserved gate region; other site 592316005280 putative PBP binding loops; other site 592316005281 ABC-ATPase subunit interface; other site 592316005282 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 592316005283 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 592316005284 Walker A/P-loop; other site 592316005285 ATP binding site [chemical binding]; other site 592316005286 Q-loop/lid; other site 592316005287 ABC transporter signature motif; other site 592316005288 Walker B; other site 592316005289 D-loop; other site 592316005290 H-loop/switch region; other site 592316005291 TOBE domain; Region: TOBE_2; pfam08402 592316005292 peptidase T; Region: peptidase-T; TIGR01882 592316005293 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 592316005294 metal binding site [ion binding]; metal-binding site 592316005295 dimer interface [polypeptide binding]; other site 592316005296 Uncharacterized conserved protein [Function unknown]; Region: COG2850 592316005297 Cupin-like domain; Region: Cupin_8; pfam13621 592316005298 sensor protein PhoQ; Provisional; Region: PRK10815 592316005299 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 592316005300 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 592316005301 dimer interface [polypeptide binding]; other site 592316005302 phosphorylation site [posttranslational modification] 592316005303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316005304 ATP binding site [chemical binding]; other site 592316005305 Mg2+ binding site [ion binding]; other site 592316005306 G-X-G motif; other site 592316005307 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 592316005308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316005309 active site 592316005310 phosphorylation site [posttranslational modification] 592316005311 intermolecular recognition site; other site 592316005312 dimerization interface [polypeptide binding]; other site 592316005313 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592316005314 DNA binding site [nucleotide binding] 592316005315 adenylosuccinate lyase; Provisional; Region: PRK09285 592316005316 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 592316005317 tetramer interface [polypeptide binding]; other site 592316005318 active site 592316005319 putative lysogenization regulator; Reviewed; Region: PRK00218 592316005320 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 592316005321 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 592316005322 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 592316005323 nudix motif; other site 592316005324 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 592316005325 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 592316005326 active site 592316005327 isocitrate dehydrogenase; Validated; Region: PRK07362 592316005328 isocitrate dehydrogenase; Reviewed; Region: PRK07006 592316005329 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 592316005330 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 592316005331 Methyltransferase domain; Region: Methyltransf_31; pfam13847 592316005332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316005333 S-adenosylmethionine binding site [chemical binding]; other site 592316005334 Glyco_18 domain; Region: Glyco_18; smart00636 592316005335 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 592316005336 active site 592316005337 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 592316005338 aromatic chitin/cellulose binding site residues [chemical binding]; other site 592316005339 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 592316005340 Protein of unknown function (DUF2767); Region: DUF2767; cl08104 592316005341 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 592316005342 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 592316005343 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 592316005344 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 592316005345 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 592316005346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316005347 Coenzyme A binding pocket [chemical binding]; other site 592316005348 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 592316005349 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 592316005350 dimer interface [polypeptide binding]; other site 592316005351 catalytic triad [active] 592316005352 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 592316005353 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 592316005354 N-acetyl-D-glucosamine binding site [chemical binding]; other site 592316005355 catalytic residue [active] 592316005356 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 592316005357 Paired Box domain; Region: PAX; cd00131 592316005358 DNA binding site [nucleotide binding] 592316005359 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 592316005360 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 592316005361 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 592316005362 ligand binding site [chemical binding]; other site 592316005363 dimerization interface [polypeptide binding]; other site 592316005364 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 592316005365 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 592316005366 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 592316005367 Walker A/P-loop; other site 592316005368 ATP binding site [chemical binding]; other site 592316005369 Q-loop/lid; other site 592316005370 ABC transporter signature motif; other site 592316005371 Walker B; other site 592316005372 D-loop; other site 592316005373 H-loop/switch region; other site 592316005374 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 592316005375 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316005376 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592316005377 TM-ABC transporter signature motif; other site 592316005378 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 592316005379 TPP-binding site [chemical binding]; other site 592316005380 dimer interface [polypeptide binding]; other site 592316005381 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 592316005382 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 592316005383 PYR/PP interface [polypeptide binding]; other site 592316005384 dimer interface [polypeptide binding]; other site 592316005385 TPP binding site [chemical binding]; other site 592316005386 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 592316005387 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 592316005388 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 592316005389 N- and C-terminal domain interface [polypeptide binding]; other site 592316005390 active site 592316005391 MgATP binding site [chemical binding]; other site 592316005392 catalytic site [active] 592316005393 metal binding site [ion binding]; metal-binding site 592316005394 putative homotetramer interface [polypeptide binding]; other site 592316005395 putative homodimer interface [polypeptide binding]; other site 592316005396 glycerol binding site [chemical binding]; other site 592316005397 Flagellar regulator YcgR; Region: YcgR; pfam07317 592316005398 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 592316005399 PilZ domain; Region: PilZ; pfam07238 592316005400 hypothetical protein; Provisional; Region: PRK10457 592316005401 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 592316005402 Helix-turn-helix domain; Region: HTH_18; pfam12833 592316005403 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 592316005404 short chain dehydrogenase; Validated; Region: PRK06182 592316005405 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 592316005406 NADP binding site [chemical binding]; other site 592316005407 active site 592316005408 steroid binding site; other site 592316005409 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 592316005410 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316005411 N-terminal plug; other site 592316005412 ligand-binding site [chemical binding]; other site 592316005413 Trehalase; Region: Trehalase; cl17346 592316005414 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 592316005415 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 592316005416 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 592316005417 putative ligand binding site [chemical binding]; other site 592316005418 NAD binding site [chemical binding]; other site 592316005419 dimerization interface [polypeptide binding]; other site 592316005420 catalytic site [active] 592316005421 putative hydrolase; Validated; Region: PRK09248 592316005422 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 592316005423 active site 592316005424 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 592316005425 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 592316005426 CoA-transferase family III; Region: CoA_transf_3; pfam02515 592316005427 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 592316005428 EamA-like transporter family; Region: EamA; pfam00892 592316005429 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 592316005430 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 592316005431 catalytic triad [active] 592316005432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316005433 S-adenosylmethionine binding site [chemical binding]; other site 592316005434 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 592316005435 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 592316005436 NAD(P) binding site [chemical binding]; other site 592316005437 catalytic residues [active] 592316005438 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316005439 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316005440 substrate binding pocket [chemical binding]; other site 592316005441 membrane-bound complex binding site; other site 592316005442 hinge residues; other site 592316005443 putative succinate dehydrogenase; Reviewed; Region: PRK12842 592316005444 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 592316005445 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 592316005446 classical (c) SDRs; Region: SDR_c; cd05233 592316005447 NAD(P) binding site [chemical binding]; other site 592316005448 active site 592316005449 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316005450 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316005451 Walker A/P-loop; other site 592316005452 ATP binding site [chemical binding]; other site 592316005453 Q-loop/lid; other site 592316005454 ABC transporter signature motif; other site 592316005455 Walker B; other site 592316005456 D-loop; other site 592316005457 H-loop/switch region; other site 592316005458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316005459 dimer interface [polypeptide binding]; other site 592316005460 conserved gate region; other site 592316005461 ABC-ATPase subunit interface; other site 592316005462 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 592316005463 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 592316005464 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 592316005465 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 592316005466 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 592316005467 [2Fe-2S] cluster binding site [ion binding]; other site 592316005468 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 592316005469 hydrophobic ligand binding site; other site 592316005470 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592316005471 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592316005472 active site 592316005473 catalytic tetrad [active] 592316005474 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 592316005475 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 592316005476 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592316005477 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316005478 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 592316005479 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 592316005480 Cyclophilin-like; Region: Cyclophil_like; cl17583 592316005481 fumarate hydratase; Provisional; Region: PRK15389 592316005482 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 592316005483 Fumarase C-terminus; Region: Fumerase_C; pfam05683 592316005484 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 592316005485 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 592316005486 transmembrane helices; other site 592316005487 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 592316005488 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 592316005489 putative active site [active] 592316005490 putative FMN binding site [chemical binding]; other site 592316005491 putative substrate binding site [chemical binding]; other site 592316005492 putative catalytic residue [active] 592316005493 FMN-binding domain; Region: FMN_bind; cl01081 592316005494 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 592316005495 L-aspartate oxidase; Provisional; Region: PRK06175 592316005496 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 592316005497 ApbE family; Region: ApbE; pfam02424 592316005498 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 592316005499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316005500 active site 592316005501 phosphorylation site [posttranslational modification] 592316005502 intermolecular recognition site; other site 592316005503 dimerization interface [polypeptide binding]; other site 592316005504 sensory histidine kinase DcuS; Provisional; Region: PRK11086 592316005505 PAS domain; Region: PAS; smart00091 592316005506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316005507 ATP binding site [chemical binding]; other site 592316005508 Mg2+ binding site [ion binding]; other site 592316005509 G-X-G motif; other site 592316005510 methionine sulfoxide reductase A; Provisional; Region: PRK14054 592316005511 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 592316005512 AAA domain; Region: AAA_33; pfam13671 592316005513 AAA domain; Region: AAA_17; pfam13207 592316005514 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 592316005515 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 592316005516 active site 592316005517 DNA binding site [nucleotide binding] 592316005518 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 592316005519 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 592316005520 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 592316005521 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 592316005522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316005523 dimer interface [polypeptide binding]; other site 592316005524 conserved gate region; other site 592316005525 putative PBP binding loops; other site 592316005526 ABC-ATPase subunit interface; other site 592316005527 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 592316005528 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 592316005529 Walker A/P-loop; other site 592316005530 ATP binding site [chemical binding]; other site 592316005531 Q-loop/lid; other site 592316005532 ABC transporter signature motif; other site 592316005533 Walker B; other site 592316005534 D-loop; other site 592316005535 H-loop/switch region; other site 592316005536 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 592316005537 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 592316005538 Trp docking motif [polypeptide binding]; other site 592316005539 putative active site [active] 592316005540 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 592316005541 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 592316005542 Catalytic site [active] 592316005543 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 592316005544 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 592316005545 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 592316005546 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 592316005547 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 592316005548 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 592316005549 active site 592316005550 homotetramer interface [polypeptide binding]; other site 592316005551 transcriptional activator FlhD; Provisional; Region: PRK02909 592316005552 transcriptional activator FlhC; Provisional; Region: PRK12722 592316005553 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 592316005554 flagellar motor protein MotA; Validated; Region: PRK09110 592316005555 flagellar motor protein MotB; Validated; Region: motB; PRK09041 592316005556 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 592316005557 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592316005558 ligand binding site [chemical binding]; other site 592316005559 chemotaxis protein CheA; Provisional; Region: PRK10547 592316005560 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 592316005561 putative binding surface; other site 592316005562 active site 592316005563 CheY binding; Region: CheY-binding; pfam09078 592316005564 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 592316005565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316005566 ATP binding site [chemical binding]; other site 592316005567 Mg2+ binding site [ion binding]; other site 592316005568 G-X-G motif; other site 592316005569 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 592316005570 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 592316005571 putative CheA interaction surface; other site 592316005572 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 592316005573 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 592316005574 dimer interface [polypeptide binding]; other site 592316005575 ligand binding site [chemical binding]; other site 592316005576 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592316005577 dimerization interface [polypeptide binding]; other site 592316005578 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592316005579 dimer interface [polypeptide binding]; other site 592316005580 putative CheW interface [polypeptide binding]; other site 592316005581 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 592316005582 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 592316005583 dimer interface [polypeptide binding]; other site 592316005584 ligand binding site [chemical binding]; other site 592316005585 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592316005586 dimerization interface [polypeptide binding]; other site 592316005587 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592316005588 dimer interface [polypeptide binding]; other site 592316005589 putative CheW interface [polypeptide binding]; other site 592316005590 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 592316005591 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 592316005592 dimer interface [polypeptide binding]; other site 592316005593 ligand binding site [chemical binding]; other site 592316005594 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592316005595 dimerization interface [polypeptide binding]; other site 592316005596 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592316005597 dimer interface [polypeptide binding]; other site 592316005598 putative CheW interface [polypeptide binding]; other site 592316005599 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 592316005600 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 592316005601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316005602 S-adenosylmethionine binding site [chemical binding]; other site 592316005603 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 592316005604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316005605 active site 592316005606 phosphorylation site [posttranslational modification] 592316005607 intermolecular recognition site; other site 592316005608 dimerization interface [polypeptide binding]; other site 592316005609 CheB methylesterase; Region: CheB_methylest; pfam01339 592316005610 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 592316005611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316005612 active site 592316005613 phosphorylation site [posttranslational modification] 592316005614 intermolecular recognition site; other site 592316005615 dimerization interface [polypeptide binding]; other site 592316005616 chemotaxis regulator CheZ; Provisional; Region: PRK11166 592316005617 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 592316005618 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 592316005619 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 592316005620 short chain dehydrogenase; Provisional; Region: PRK06841 592316005621 classical (c) SDRs; Region: SDR_c; cd05233 592316005622 NAD(P) binding site [chemical binding]; other site 592316005623 active site 592316005624 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 592316005625 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 592316005626 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 592316005627 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 592316005628 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 592316005629 Walker A/P-loop; other site 592316005630 ATP binding site [chemical binding]; other site 592316005631 Q-loop/lid; other site 592316005632 ABC transporter signature motif; other site 592316005633 Walker B; other site 592316005634 D-loop; other site 592316005635 H-loop/switch region; other site 592316005636 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 592316005637 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592316005638 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316005639 TM-ABC transporter signature motif; other site 592316005640 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 592316005641 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316005642 NAD(P) binding site [chemical binding]; other site 592316005643 active site 592316005644 putative invasin; Provisional; Region: PRK10177 592316005645 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 592316005646 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 592316005647 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 592316005648 trimer interface [polypeptide binding]; other site 592316005649 eyelet of channel; other site 592316005650 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 592316005651 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592316005652 inhibitor-cofactor binding pocket; inhibition site 592316005653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316005654 catalytic residue [active] 592316005655 arginine succinyltransferase; Provisional; Region: PRK10456 592316005656 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 592316005657 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 592316005658 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 592316005659 NAD(P) binding site [chemical binding]; other site 592316005660 catalytic residues [active] 592316005661 succinylarginine dihydrolase; Provisional; Region: PRK13281 592316005662 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 592316005663 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 592316005664 putative active site [active] 592316005665 Zn binding site [ion binding]; other site 592316005666 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 592316005667 dimer interface [polypeptide binding]; other site 592316005668 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 592316005669 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 592316005670 GIY-YIG motif/motif A; other site 592316005671 active site 592316005672 catalytic site [active] 592316005673 putative DNA binding site [nucleotide binding]; other site 592316005674 metal binding site [ion binding]; metal-binding site 592316005675 aromatic amino acid exporter; Provisional; Region: PRK11689 592316005676 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 592316005677 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 592316005678 homodimer interface [polypeptide binding]; other site 592316005679 NAD binding pocket [chemical binding]; other site 592316005680 ATP binding pocket [chemical binding]; other site 592316005681 Mg binding site [ion binding]; other site 592316005682 active-site loop [active] 592316005683 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 592316005684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316005685 putative substrate translocation pore; other site 592316005686 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592316005687 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316005688 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 592316005689 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 592316005690 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 592316005691 inner membrane protein; Provisional; Region: PRK11648 592316005692 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 592316005693 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 592316005694 NADP binding site [chemical binding]; other site 592316005695 homodimer interface [polypeptide binding]; other site 592316005696 active site 592316005697 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 592316005698 Enolase, N-terminal domain; Region: Enolase_N; pfam03952 592316005699 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 592316005700 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 592316005701 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316005702 motif II; other site 592316005703 YniB-like protein; Region: YniB; pfam14002 592316005704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3001 592316005705 Phosphotransferase enzyme family; Region: APH; pfam01636 592316005706 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 592316005707 Protein of unknown function, DUF481; Region: DUF481; cl01213 592316005708 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 592316005709 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 592316005710 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 592316005711 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 592316005712 active site 592316005713 dimer interface [polypeptide binding]; other site 592316005714 motif 1; other site 592316005715 motif 2; other site 592316005716 motif 3; other site 592316005717 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 592316005718 anticodon binding site; other site 592316005719 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 592316005720 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 592316005721 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 592316005722 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 592316005723 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 592316005724 23S rRNA binding site [nucleotide binding]; other site 592316005725 L21 binding site [polypeptide binding]; other site 592316005726 L13 binding site [polypeptide binding]; other site 592316005727 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 592316005728 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 592316005729 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 592316005730 dimer interface [polypeptide binding]; other site 592316005731 motif 1; other site 592316005732 active site 592316005733 motif 2; other site 592316005734 motif 3; other site 592316005735 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 592316005736 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 592316005737 putative tRNA-binding site [nucleotide binding]; other site 592316005738 B3/4 domain; Region: B3_4; pfam03483 592316005739 tRNA synthetase B5 domain; Region: B5; smart00874 592316005740 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 592316005741 dimer interface [polypeptide binding]; other site 592316005742 motif 1; other site 592316005743 motif 3; other site 592316005744 motif 2; other site 592316005745 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 592316005746 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 592316005747 IHF dimer interface [polypeptide binding]; other site 592316005748 IHF - DNA interface [nucleotide binding]; other site 592316005749 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 592316005750 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 592316005751 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592316005752 ABC-ATPase subunit interface; other site 592316005753 dimer interface [polypeptide binding]; other site 592316005754 putative PBP binding regions; other site 592316005755 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 592316005756 catalytic residues [active] 592316005757 dimer interface [polypeptide binding]; other site 592316005758 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 592316005759 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 592316005760 Walker A/P-loop; other site 592316005761 ATP binding site [chemical binding]; other site 592316005762 Q-loop/lid; other site 592316005763 ABC transporter signature motif; other site 592316005764 Walker B; other site 592316005765 D-loop; other site 592316005766 H-loop/switch region; other site 592316005767 NlpC/P60 family; Region: NLPC_P60; pfam00877 592316005768 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 592316005769 Uncharacterized conserved protein [Function unknown]; Region: COG0397 592316005770 hypothetical protein; Validated; Region: PRK00029 592316005771 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 592316005772 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 592316005773 PEP synthetase regulatory protein; Provisional; Region: PRK05339 592316005774 phosphoenolpyruvate synthase; Validated; Region: PRK06464 592316005775 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 592316005776 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 592316005777 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 592316005778 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 592316005779 active site 592316005780 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 592316005781 putative inner membrane protein; Provisional; Region: PRK10983 592316005782 Domain of unknown function DUF20; Region: UPF0118; pfam01594 592316005783 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 592316005784 FAD binding domain; Region: FAD_binding_4; pfam01565 592316005785 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 592316005786 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 592316005787 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 592316005788 putative ABC transporter; Region: ycf24; CHL00085 592316005789 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 592316005790 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 592316005791 Walker A/P-loop; other site 592316005792 ATP binding site [chemical binding]; other site 592316005793 Q-loop/lid; other site 592316005794 ABC transporter signature motif; other site 592316005795 Walker B; other site 592316005796 D-loop; other site 592316005797 H-loop/switch region; other site 592316005798 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 592316005799 FeS assembly protein SufD; Region: sufD; TIGR01981 592316005800 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 592316005801 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 592316005802 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592316005803 catalytic residue [active] 592316005804 cysteine desufuration protein SufE; Provisional; Region: PRK09296 592316005805 L,D-transpeptidase; Provisional; Region: PRK10190 592316005806 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 592316005807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316005808 active site 592316005809 murein lipoprotein; Provisional; Region: PRK15396 592316005810 pyruvate kinase; Provisional; Region: PRK09206 592316005811 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 592316005812 domain interfaces; other site 592316005813 active site 592316005814 multidrug efflux protein; Reviewed; Region: PRK01766 592316005815 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 592316005816 cation binding site [ion binding]; other site 592316005817 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 592316005818 Lumazine binding domain; Region: Lum_binding; pfam00677 592316005819 Lumazine binding domain; Region: Lum_binding; pfam00677 592316005820 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 592316005821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 592316005822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316005823 S-adenosylmethionine binding site [chemical binding]; other site 592316005824 putative transporter; Provisional; Region: PRK11043 592316005825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316005826 putative substrate translocation pore; other site 592316005827 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 592316005828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316005829 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316005830 dimerization interface [polypeptide binding]; other site 592316005831 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 592316005832 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316005833 DNA binding site [nucleotide binding] 592316005834 domain linker motif; other site 592316005835 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 592316005836 dimerization interface [polypeptide binding]; other site 592316005837 ligand binding site [chemical binding]; other site 592316005838 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 592316005839 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 592316005840 NlpC/P60 family; Region: NLPC_P60; pfam00877 592316005841 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 592316005842 putative GSH binding site [chemical binding]; other site 592316005843 catalytic residues [active] 592316005844 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 592316005845 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 592316005846 dimer interface [polypeptide binding]; other site 592316005847 catalytic site [active] 592316005848 putative active site [active] 592316005849 putative substrate binding site [chemical binding]; other site 592316005850 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592316005851 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 592316005852 dimer interface [polypeptide binding]; other site 592316005853 active site 592316005854 metal binding site [ion binding]; metal-binding site 592316005855 glutathione binding site [chemical binding]; other site 592316005856 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 592316005857 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 592316005858 FMN binding site [chemical binding]; other site 592316005859 active site 592316005860 substrate binding site [chemical binding]; other site 592316005861 catalytic residue [active] 592316005862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592316005863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316005864 putative metal dependent hydrolase; Provisional; Region: PRK11598 592316005865 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 592316005866 Sulfatase; Region: Sulfatase; pfam00884 592316005867 Predicted Fe-S protein [General function prediction only]; Region: COG3313 592316005868 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592316005869 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592316005870 active site 592316005871 catalytic tetrad [active] 592316005872 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 592316005873 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 592316005874 E-class dimer interface [polypeptide binding]; other site 592316005875 P-class dimer interface [polypeptide binding]; other site 592316005876 active site 592316005877 Cu2+ binding site [ion binding]; other site 592316005878 Zn2+ binding site [ion binding]; other site 592316005879 Fusaric acid resistance protein family; Region: FUSC; pfam04632 592316005880 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 592316005881 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 592316005882 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592316005883 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316005884 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 592316005885 transcriptional regulator SlyA; Provisional; Region: PRK03573 592316005886 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 592316005887 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 592316005888 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 592316005889 DNA binding residues [nucleotide binding] 592316005890 haemagglutination activity domain; Region: Haemagg_act; pfam05860 592316005891 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 592316005892 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 592316005893 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 592316005894 Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736 592316005895 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 592316005896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316005897 NAD(P) binding site [chemical binding]; other site 592316005898 active site 592316005899 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 592316005900 active site 2 [active] 592316005901 active site 1 [active] 592316005902 Phosphopantetheine attachment site; Region: PP-binding; cl09936 592316005903 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 592316005904 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 592316005905 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 592316005906 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 592316005907 dimer interface [polypeptide binding]; other site 592316005908 active site 592316005909 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 592316005910 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 592316005911 active site 592316005912 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 592316005913 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 592316005914 active site 592316005915 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 592316005916 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 592316005917 Walker A/P-loop; other site 592316005918 ATP binding site [chemical binding]; other site 592316005919 Q-loop/lid; other site 592316005920 ABC transporter signature motif; other site 592316005921 Walker B; other site 592316005922 D-loop; other site 592316005923 H-loop/switch region; other site 592316005924 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 592316005925 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 592316005926 FtsX-like permease family; Region: FtsX; pfam02687 592316005927 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 592316005928 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 592316005929 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592316005930 DNA binding residues [nucleotide binding] 592316005931 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 592316005932 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 592316005933 lysozyme inhibitor; Provisional; Region: PRK11372 592316005934 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 592316005935 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 592316005936 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 592316005937 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 592316005938 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 592316005939 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 592316005940 active site 592316005941 HIGH motif; other site 592316005942 dimer interface [polypeptide binding]; other site 592316005943 KMSKS motif; other site 592316005944 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592316005945 RNA binding surface [nucleotide binding]; other site 592316005946 pyridoxamine kinase; Validated; Region: PRK05756 592316005947 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 592316005948 dimer interface [polypeptide binding]; other site 592316005949 pyridoxal binding site [chemical binding]; other site 592316005950 ATP binding site [chemical binding]; other site 592316005951 glutathionine S-transferase; Provisional; Region: PRK10542 592316005952 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 592316005953 C-terminal domain interface [polypeptide binding]; other site 592316005954 GSH binding site (G-site) [chemical binding]; other site 592316005955 dimer interface [polypeptide binding]; other site 592316005956 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 592316005957 dimer interface [polypeptide binding]; other site 592316005958 N-terminal domain interface [polypeptide binding]; other site 592316005959 substrate binding pocket (H-site) [chemical binding]; other site 592316005960 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316005961 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316005962 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 592316005963 putative effector binding pocket; other site 592316005964 putative dimerization interface [polypeptide binding]; other site 592316005965 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 592316005966 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 592316005967 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 592316005968 putative N-terminal domain interface [polypeptide binding]; other site 592316005969 putative dimer interface [polypeptide binding]; other site 592316005970 putative substrate binding pocket (H-site) [chemical binding]; other site 592316005971 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 592316005972 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 592316005973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316005974 putative substrate translocation pore; other site 592316005975 BCCT family transporter; Region: BCCT; cl00569 592316005976 transcriptional regulator BetI; Validated; Region: PRK00767 592316005977 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316005978 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 592316005979 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 592316005980 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 592316005981 tetrameric interface [polypeptide binding]; other site 592316005982 NAD binding site [chemical binding]; other site 592316005983 catalytic residues [active] 592316005984 choline dehydrogenase; Validated; Region: PRK02106 592316005985 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 592316005986 hypothetical protein; Validated; Region: PRK06186 592316005987 conserved cys residue [active] 592316005988 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 592316005989 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 592316005990 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 592316005991 NADP binding site [chemical binding]; other site 592316005992 dimer interface [polypeptide binding]; other site 592316005993 endonuclease III; Provisional; Region: PRK10702 592316005994 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 592316005995 minor groove reading motif; other site 592316005996 helix-hairpin-helix signature motif; other site 592316005997 substrate binding pocket [chemical binding]; other site 592316005998 active site 592316005999 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 592316006000 electron transport complex RsxE subunit; Provisional; Region: PRK12405 592316006001 electron transport complex protein RnfG; Validated; Region: PRK01908 592316006002 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 592316006003 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 592316006004 SLBB domain; Region: SLBB; pfam10531 592316006005 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 592316006006 electron transport complex protein RnfB; Provisional; Region: PRK05113 592316006007 Putative Fe-S cluster; Region: FeS; cl17515 592316006008 4Fe-4S binding domain; Region: Fer4; pfam00037 592316006009 electron transport complex protein RsxA; Provisional; Region: PRK05151 592316006010 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 592316006011 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 592316006012 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 592316006013 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 592316006014 putative ligand binding site [chemical binding]; other site 592316006015 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 592316006016 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 592316006017 Walker A/P-loop; other site 592316006018 ATP binding site [chemical binding]; other site 592316006019 Q-loop/lid; other site 592316006020 ABC transporter signature motif; other site 592316006021 Walker B; other site 592316006022 D-loop; other site 592316006023 H-loop/switch region; other site 592316006024 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 592316006025 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316006026 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592316006027 TM-ABC transporter signature motif; other site 592316006028 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316006029 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592316006030 TM-ABC transporter signature motif; other site 592316006031 putative transposase; Provisional; Region: PRK09857 592316006032 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 592316006033 L-arabinose isomerase; Provisional; Region: PRK02929 592316006034 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 592316006035 hexamer (dimer of trimers) interface [polypeptide binding]; other site 592316006036 trimer interface [polypeptide binding]; other site 592316006037 substrate binding site [chemical binding]; other site 592316006038 Mn binding site [ion binding]; other site 592316006039 ribulokinase; Provisional; Region: PRK04123 592316006040 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 592316006041 N- and C-terminal domain interface [polypeptide binding]; other site 592316006042 active site 592316006043 MgATP binding site [chemical binding]; other site 592316006044 catalytic site [active] 592316006045 metal binding site [ion binding]; metal-binding site 592316006046 carbohydrate binding site [chemical binding]; other site 592316006047 homodimer interface [polypeptide binding]; other site 592316006048 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 592316006049 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 592316006050 ligand binding site [chemical binding]; other site 592316006051 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 592316006052 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 592316006053 Walker A/P-loop; other site 592316006054 ATP binding site [chemical binding]; other site 592316006055 Q-loop/lid; other site 592316006056 ABC transporter signature motif; other site 592316006057 Walker B; other site 592316006058 D-loop; other site 592316006059 H-loop/switch region; other site 592316006060 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 592316006061 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592316006062 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316006063 TM-ABC transporter signature motif; other site 592316006064 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 592316006065 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 592316006066 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316006067 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316006068 putative oxidoreductase; Provisional; Region: PRK11579 592316006069 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592316006070 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592316006071 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 592316006072 aromatic chitin/cellulose binding site residues [chemical binding]; other site 592316006073 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 592316006074 aromatic chitin/cellulose binding site residues [chemical binding]; other site 592316006075 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 592316006076 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 592316006077 putative sugar binding site [chemical binding]; other site 592316006078 catalytic residues [active] 592316006079 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 592316006080 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 592316006081 active site 592316006082 purine riboside binding site [chemical binding]; other site 592316006083 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 592316006084 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316006085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316006086 homodimer interface [polypeptide binding]; other site 592316006087 catalytic residue [active] 592316006088 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 592316006089 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 592316006090 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 592316006091 active site turn [active] 592316006092 phosphorylation site [posttranslational modification] 592316006093 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 592316006094 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316006095 DNA binding site [nucleotide binding] 592316006096 domain linker motif; other site 592316006097 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 592316006098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 592316006099 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 592316006100 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 592316006101 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 592316006102 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 592316006103 fumarate hydratase; Reviewed; Region: fumC; PRK00485 592316006104 Class II fumarases; Region: Fumarase_classII; cd01362 592316006105 active site 592316006106 tetramer interface [polypeptide binding]; other site 592316006107 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 592316006108 Predicted transcriptional regulator [Transcription]; Region: COG1959 592316006109 Transcriptional regulator; Region: Rrf2; pfam02082 592316006110 Transcriptional regulator; Region: Rrf2; cl17282 592316006111 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 592316006112 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 592316006113 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592316006114 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316006115 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 592316006116 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316006117 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 592316006118 active site 592316006119 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 592316006120 RNAase interaction site [polypeptide binding]; other site 592316006121 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 592316006122 Virulence factor SrfB; Region: SrfB; pfam07520 592316006123 Benzoate membrane transport protein; Region: BenE; pfam03594 592316006124 benzoate transporter; Region: benE; TIGR00843 592316006125 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316006126 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592316006127 non-specific DNA binding site [nucleotide binding]; other site 592316006128 salt bridge; other site 592316006129 sequence-specific DNA binding site [nucleotide binding]; other site 592316006130 Cupin domain; Region: Cupin_2; cl17218 592316006131 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592316006132 MarR family; Region: MarR_2; pfam12802 592316006133 Isochorismatase family; Region: Isochorismatase; pfam00857 592316006134 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 592316006135 catalytic triad [active] 592316006136 conserved cis-peptide bond; other site 592316006137 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 592316006138 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316006139 N-terminal plug; other site 592316006140 ligand-binding site [chemical binding]; other site 592316006141 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 592316006142 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316006143 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316006144 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 592316006145 putative effector binding pocket; other site 592316006146 dimerization interface [polypeptide binding]; other site 592316006147 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 592316006148 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 592316006149 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 592316006150 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 592316006151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316006152 2-isopropylmalate synthase; Validated; Region: PRK03739 592316006153 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 592316006154 active site 592316006155 catalytic residues [active] 592316006156 metal binding site [ion binding]; metal-binding site 592316006157 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 592316006158 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 592316006159 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316006160 membrane-bound complex binding site; other site 592316006161 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 592316006162 active site 592316006163 dimer interface [polypeptide binding]; other site 592316006164 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 592316006165 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 592316006166 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 592316006167 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 592316006168 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 592316006169 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 592316006170 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 592316006171 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592316006172 FeS/SAM binding site; other site 592316006173 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 592316006174 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 592316006175 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 592316006176 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 592316006177 Uncharacterized conserved protein [Function unknown]; Region: COG2353 592316006178 D-lactate dehydrogenase; Provisional; Region: PRK11183 592316006179 FAD binding domain; Region: FAD_binding_4; pfam01565 592316006180 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 592316006181 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 592316006182 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 592316006183 active site 592316006184 ADP/pyrophosphate binding site [chemical binding]; other site 592316006185 dimerization interface [polypeptide binding]; other site 592316006186 allosteric effector site; other site 592316006187 fructose-1,6-bisphosphate binding site; other site 592316006188 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 592316006189 active site 592316006190 P-loop; other site 592316006191 phosphorylation site [posttranslational modification] 592316006192 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 592316006193 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 592316006194 intersubunit interface [polypeptide binding]; other site 592316006195 active site 592316006196 zinc binding site [ion binding]; other site 592316006197 Na+ binding site [ion binding]; other site 592316006198 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 592316006199 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 592316006200 active site 592316006201 phosphorylation site [posttranslational modification] 592316006202 AAA domain; Region: AAA_33; pfam13671 592316006203 AAA domain; Region: AAA_17; pfam13207 592316006204 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 592316006205 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 592316006206 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 592316006207 classical (c) SDRs; Region: SDR_c; cd05233 592316006208 NAD(P) binding site [chemical binding]; other site 592316006209 active site 592316006210 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 592316006211 hypothetical protein; Provisional; Region: PRK09273 592316006212 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 592316006213 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 592316006214 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 592316006215 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316006216 Walker A/P-loop; other site 592316006217 ATP binding site [chemical binding]; other site 592316006218 Q-loop/lid; other site 592316006219 ABC transporter signature motif; other site 592316006220 Walker B; other site 592316006221 D-loop; other site 592316006222 H-loop/switch region; other site 592316006223 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 592316006224 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316006225 Walker A/P-loop; other site 592316006226 ATP binding site [chemical binding]; other site 592316006227 Q-loop/lid; other site 592316006228 ABC transporter signature motif; other site 592316006229 Walker B; other site 592316006230 D-loop; other site 592316006231 H-loop/switch region; other site 592316006232 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316006233 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 592316006234 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 592316006235 dimer interface [polypeptide binding]; other site 592316006236 conserved gate region; other site 592316006237 ABC-ATPase subunit interface; other site 592316006238 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316006239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316006240 dimer interface [polypeptide binding]; other site 592316006241 conserved gate region; other site 592316006242 putative PBP binding loops; other site 592316006243 ABC-ATPase subunit interface; other site 592316006244 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592316006245 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 592316006246 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 592316006247 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 592316006248 putative active site pocket [active] 592316006249 metal binding site [ion binding]; metal-binding site 592316006250 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 592316006251 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 592316006252 putative ligand binding residues [chemical binding]; other site 592316006253 Amidase; Region: Amidase; cl11426 592316006254 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 592316006255 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 592316006256 active site 592316006257 iron coordination sites [ion binding]; other site 592316006258 substrate binding pocket [chemical binding]; other site 592316006259 aldolase II superfamily protein; Provisional; Region: PRK07044 592316006260 intersubunit interface [polypeptide binding]; other site 592316006261 active site 592316006262 Zn2+ binding site [ion binding]; other site 592316006263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 592316006264 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 592316006265 dimer interface [polypeptide binding]; other site 592316006266 conserved gate region; other site 592316006267 putative PBP binding loops; other site 592316006268 ABC-ATPase subunit interface; other site 592316006269 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 592316006270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316006271 dimer interface [polypeptide binding]; other site 592316006272 conserved gate region; other site 592316006273 putative PBP binding loops; other site 592316006274 ABC-ATPase subunit interface; other site 592316006275 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 592316006276 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 592316006277 Walker A/P-loop; other site 592316006278 ATP binding site [chemical binding]; other site 592316006279 Q-loop/lid; other site 592316006280 ABC transporter signature motif; other site 592316006281 Walker B; other site 592316006282 D-loop; other site 592316006283 H-loop/switch region; other site 592316006284 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 592316006285 NMT1/THI5 like; Region: NMT1; pfam09084 592316006286 Transcriptional regulators [Transcription]; Region: GntR; COG1802 592316006287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316006288 DNA-binding site [nucleotide binding]; DNA binding site 592316006289 FCD domain; Region: FCD; pfam07729 592316006290 short chain dehydrogenase; Provisional; Region: PRK06125 592316006291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316006292 NAD(P) binding site [chemical binding]; other site 592316006293 active site 592316006294 aspartate aminotransferase; Provisional; Region: PRK06225 592316006295 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316006296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316006297 homodimer interface [polypeptide binding]; other site 592316006298 catalytic residue [active] 592316006299 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 592316006300 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 592316006301 allantoate amidohydrolase; Reviewed; Region: PRK12893 592316006302 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 592316006303 active site 592316006304 metal binding site [ion binding]; metal-binding site 592316006305 dimer interface [polypeptide binding]; other site 592316006306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316006307 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592316006308 putative substrate translocation pore; other site 592316006309 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 592316006310 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 592316006311 putative NAD(P) binding site [chemical binding]; other site 592316006312 catalytic Zn binding site [ion binding]; other site 592316006313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316006314 D-galactonate transporter; Region: 2A0114; TIGR00893 592316006315 putative substrate translocation pore; other site 592316006316 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 592316006317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316006318 NAD(P) binding site [chemical binding]; other site 592316006319 active site 592316006320 Transcriptional regulators [Transcription]; Region: FadR; COG2186 592316006321 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316006322 DNA-binding site [nucleotide binding]; DNA binding site 592316006323 FCD domain; Region: FCD; pfam07729 592316006324 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 592316006325 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 592316006326 metal binding site [ion binding]; metal-binding site 592316006327 substrate binding pocket [chemical binding]; other site 592316006328 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 592316006329 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 592316006330 trimer interface [polypeptide binding]; other site 592316006331 active site 592316006332 substrate binding site [chemical binding]; other site 592316006333 CoA binding site [chemical binding]; other site 592316006334 Domain of unknown function (DUF1792); Region: DUF1792; cl07392 592316006335 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 592316006336 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 592316006337 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 592316006338 Trp docking motif [polypeptide binding]; other site 592316006339 putative active site [active] 592316006340 topology modulation protein; Reviewed; Region: PRK08118 592316006341 AAA domain; Region: AAA_17; pfam13207 592316006342 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 592316006343 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 592316006344 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592316006345 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316006346 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 592316006347 Protein export membrane protein; Region: SecD_SecF; cl14618 592316006348 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 592316006349 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592316006350 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316006351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592316006352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316006353 Pirin; Region: Pirin; pfam02678 592316006354 Pirin-related protein [General function prediction only]; Region: COG1741 592316006355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316006356 short chain dehydrogenase; Provisional; Region: PRK08339 592316006357 NAD(P) binding site [chemical binding]; other site 592316006358 active site 592316006359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 592316006360 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 592316006361 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 592316006362 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 592316006363 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 592316006364 homotrimer interaction site [polypeptide binding]; other site 592316006365 putative active site [active] 592316006366 Predicted transcriptional regulators [Transcription]; Region: COG1695 592316006367 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 592316006368 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 592316006369 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 592316006370 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 592316006371 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 592316006372 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 592316006373 Amidohydrolase; Region: Amidohydro_2; pfam04909 592316006374 hypothetical protein; Provisional; Region: PRK07538 592316006375 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 592316006376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316006377 putative substrate translocation pore; other site 592316006378 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592316006379 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 592316006380 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 592316006381 tetramer interface [polypeptide binding]; other site 592316006382 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 592316006383 tetramer interface [polypeptide binding]; other site 592316006384 active site 592316006385 metal binding site [ion binding]; metal-binding site 592316006386 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 592316006387 osmolarity response regulator; Provisional; Region: ompR; PRK09468 592316006388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316006389 active site 592316006390 phosphorylation site [posttranslational modification] 592316006391 intermolecular recognition site; other site 592316006392 dimerization interface [polypeptide binding]; other site 592316006393 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592316006394 DNA binding site [nucleotide binding] 592316006395 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592316006396 HAMP domain; Region: HAMP; pfam00672 592316006397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316006398 dimer interface [polypeptide binding]; other site 592316006399 phosphorylation site [posttranslational modification] 592316006400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316006401 ATP binding site [chemical binding]; other site 592316006402 Mg2+ binding site [ion binding]; other site 592316006403 G-X-G motif; other site 592316006404 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 592316006405 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592316006406 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 592316006407 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 592316006408 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 592316006409 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 592316006410 catalytic residues [active] 592316006411 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 592316006412 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 592316006413 NAD binding site [chemical binding]; other site 592316006414 catalytic residues [active] 592316006415 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316006416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316006417 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 592316006418 putative effector binding pocket; other site 592316006419 putative dimerization interface [polypeptide binding]; other site 592316006420 diguanylate cyclase; Provisional; Region: PRK09894 592316006421 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 592316006422 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316006423 metal binding site [ion binding]; metal-binding site 592316006424 active site 592316006425 I-site; other site 592316006426 RES domain; Region: RES; cl02411 592316006427 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 592316006428 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 592316006429 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 592316006430 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 592316006431 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 592316006432 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 592316006433 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592316006434 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 592316006435 ATP binding site [chemical binding]; other site 592316006436 putative Mg++ binding site [ion binding]; other site 592316006437 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592316006438 nucleotide binding region [chemical binding]; other site 592316006439 ATP-binding site [chemical binding]; other site 592316006440 DEAD/H associated; Region: DEAD_assoc; pfam08494 592316006441 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 592316006442 substrate binding site [chemical binding]; other site 592316006443 Transcriptional regulator [Transcription]; Region: IclR; COG1414 592316006444 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 592316006445 Bacterial transcriptional regulator; Region: IclR; pfam01614 592316006446 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 592316006447 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 592316006448 Walker A/P-loop; other site 592316006449 ATP binding site [chemical binding]; other site 592316006450 Q-loop/lid; other site 592316006451 ABC transporter signature motif; other site 592316006452 Walker B; other site 592316006453 D-loop; other site 592316006454 H-loop/switch region; other site 592316006455 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 592316006456 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316006457 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592316006458 TM-ABC transporter signature motif; other site 592316006459 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315 592316006460 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 592316006461 putative ligand binding site [chemical binding]; other site 592316006462 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 592316006463 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 592316006464 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 592316006465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316006466 D-galactonate transporter; Region: 2A0114; TIGR00893 592316006467 putative substrate translocation pore; other site 592316006468 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 592316006469 putative N- and C-terminal domain interface [polypeptide binding]; other site 592316006470 L-fuculokinase; Region: fuculo_kin_coli; TIGR02628 592316006471 putative active site [active] 592316006472 MgATP binding site [chemical binding]; other site 592316006473 catalytic site [active] 592316006474 metal binding site [ion binding]; metal-binding site 592316006475 putative xylulose binding site [chemical binding]; other site 592316006476 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 592316006477 active site 592316006478 magnesium binding site [ion binding]; other site 592316006479 dimer interface [polypeptide binding]; other site 592316006480 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 592316006481 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 592316006482 AP (apurinic/apyrimidinic) site pocket; other site 592316006483 DNA interaction; other site 592316006484 Metal-binding active site; metal-binding site 592316006485 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 592316006486 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 592316006487 intersubunit interface [polypeptide binding]; other site 592316006488 active site 592316006489 Zn2+ binding site [ion binding]; other site 592316006490 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 592316006491 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316006492 N-terminal plug; other site 592316006493 ligand-binding site [chemical binding]; other site 592316006494 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 592316006495 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 592316006496 intersubunit interface [polypeptide binding]; other site 592316006497 active site 592316006498 zinc binding site [ion binding]; other site 592316006499 Na+ binding site [ion binding]; other site 592316006500 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 592316006501 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 592316006502 dimer interface [polypeptide binding]; other site 592316006503 active site 592316006504 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 592316006505 putative active site [active] 592316006506 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 592316006507 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 592316006508 active site 592316006509 dimer interface [polypeptide binding]; other site 592316006510 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 592316006511 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 592316006512 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 592316006513 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 592316006514 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592316006515 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592316006516 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592316006517 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 592316006518 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 592316006519 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 592316006520 fructokinase; Reviewed; Region: PRK09557 592316006521 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 592316006522 nucleotide binding site [chemical binding]; other site 592316006523 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 592316006524 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 592316006525 Walker A/P-loop; other site 592316006526 ATP binding site [chemical binding]; other site 592316006527 Q-loop/lid; other site 592316006528 ABC transporter signature motif; other site 592316006529 Walker B; other site 592316006530 D-loop; other site 592316006531 H-loop/switch region; other site 592316006532 TOBE domain; Region: TOBE_2; pfam08402 592316006533 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 592316006534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316006535 dimer interface [polypeptide binding]; other site 592316006536 conserved gate region; other site 592316006537 putative PBP binding loops; other site 592316006538 ABC-ATPase subunit interface; other site 592316006539 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 592316006540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316006541 ABC-ATPase subunit interface; other site 592316006542 putative PBP binding loops; other site 592316006543 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 592316006544 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 592316006545 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 592316006546 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 592316006547 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 592316006548 Predicted amidohydrolase [General function prediction only]; Region: COG0388 592316006549 putative active site [active] 592316006550 catalytic triad [active] 592316006551 putative dimer interface [polypeptide binding]; other site 592316006552 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316006553 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316006554 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 592316006555 putative substrate binding pocket [chemical binding]; other site 592316006556 putative dimerization interface [polypeptide binding]; other site 592316006557 FAD dependent oxidoreductase; Region: DAO; pfam01266 592316006558 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 592316006559 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 592316006560 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 592316006561 homotrimer interaction site [polypeptide binding]; other site 592316006562 putative active site [active] 592316006563 amidase; Provisional; Region: PRK07486 592316006564 Amidase; Region: Amidase; cl11426 592316006565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316006566 D-galactonate transporter; Region: 2A0114; TIGR00893 592316006567 putative substrate translocation pore; other site 592316006568 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316006569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316006570 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316006571 dimerization interface [polypeptide binding]; other site 592316006572 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316006573 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316006574 Walker A/P-loop; other site 592316006575 ATP binding site [chemical binding]; other site 592316006576 Q-loop/lid; other site 592316006577 ABC transporter signature motif; other site 592316006578 Walker B; other site 592316006579 D-loop; other site 592316006580 H-loop/switch region; other site 592316006581 M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697 592316006582 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 592316006583 putative metal binding site [ion binding]; other site 592316006584 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 592316006585 catalytic loop [active] 592316006586 iron binding site [ion binding]; other site 592316006587 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 592316006588 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 592316006589 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 592316006590 hydroxyglutarate oxidase; Provisional; Region: PRK11728 592316006591 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 592316006592 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 592316006593 inhibitor site; inhibition site 592316006594 active site 592316006595 dimer interface [polypeptide binding]; other site 592316006596 catalytic residue [active] 592316006597 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316006598 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316006599 substrate binding pocket [chemical binding]; other site 592316006600 membrane-bound complex binding site; other site 592316006601 hinge residues; other site 592316006602 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316006603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316006604 dimer interface [polypeptide binding]; other site 592316006605 conserved gate region; other site 592316006606 putative PBP binding loops; other site 592316006607 ABC-ATPase subunit interface; other site 592316006608 dihydropyrimidinase; Provisional; Region: PRK13404 592316006609 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 592316006610 tetramer interface [polypeptide binding]; other site 592316006611 active site 592316006612 Transcriptional regulators [Transcription]; Region: GntR; COG1802 592316006613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316006614 DNA-binding site [nucleotide binding]; DNA binding site 592316006615 FCD domain; Region: FCD; pfam07729 592316006616 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 592316006617 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 592316006618 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316006619 DNA-binding site [nucleotide binding]; DNA binding site 592316006620 Transcriptional regulators [Transcription]; Region: FadR; COG2186 592316006621 FCD domain; Region: FCD; pfam07729 592316006622 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316006623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316006624 dimer interface [polypeptide binding]; other site 592316006625 conserved gate region; other site 592316006626 putative PBP binding loops; other site 592316006627 ABC-ATPase subunit interface; other site 592316006628 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316006629 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316006630 Walker A/P-loop; other site 592316006631 ATP binding site [chemical binding]; other site 592316006632 Q-loop/lid; other site 592316006633 ABC transporter signature motif; other site 592316006634 Walker B; other site 592316006635 D-loop; other site 592316006636 H-loop/switch region; other site 592316006637 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316006638 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316006639 substrate binding pocket [chemical binding]; other site 592316006640 membrane-bound complex binding site; other site 592316006641 hinge residues; other site 592316006642 Predicted flavoprotein [General function prediction only]; Region: COG0431 592316006643 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592316006644 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 592316006645 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 592316006646 trimer interface [polypeptide binding]; other site 592316006647 eyelet of channel; other site 592316006648 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 592316006649 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 592316006650 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 592316006651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316006652 active site 592316006653 phosphorylation site [posttranslational modification] 592316006654 intermolecular recognition site; other site 592316006655 dimerization interface [polypeptide binding]; other site 592316006656 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592316006657 DNA binding residues [nucleotide binding] 592316006658 dimerization interface [polypeptide binding]; other site 592316006659 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 592316006660 substrate binding site [chemical binding]; other site 592316006661 activation loop (A-loop); other site 592316006662 Predicted ATPase [General function prediction only]; Region: COG3899 592316006663 AAA ATPase domain; Region: AAA_16; pfam13191 592316006664 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 592316006665 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 592316006666 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592316006667 PAS fold; Region: PAS_3; pfam08447 592316006668 putative active site [active] 592316006669 heme pocket [chemical binding]; other site 592316006670 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316006671 dimer interface [polypeptide binding]; other site 592316006672 phosphorylation site [posttranslational modification] 592316006673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316006674 ATP binding site [chemical binding]; other site 592316006675 Mg2+ binding site [ion binding]; other site 592316006676 G-X-G motif; other site 592316006677 Response regulator receiver domain; Region: Response_reg; pfam00072 592316006678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316006679 active site 592316006680 phosphorylation site [posttranslational modification] 592316006681 intermolecular recognition site; other site 592316006682 dimerization interface [polypeptide binding]; other site 592316006683 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 592316006684 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 592316006685 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 592316006686 Isochorismatase family; Region: Isochorismatase; pfam00857 592316006687 catalytic triad [active] 592316006688 dimer interface [polypeptide binding]; other site 592316006689 conserved cis-peptide bond; other site 592316006690 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 592316006691 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 592316006692 active site 592316006693 DoxX; Region: DoxX; pfam07681 592316006694 Transmembrane secretion effector; Region: MFS_3; pfam05977 592316006695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316006696 putative substrate translocation pore; other site 592316006697 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 592316006698 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 592316006699 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592316006700 Pirin-related protein [General function prediction only]; Region: COG1741 592316006701 Pirin; Region: Pirin; pfam02678 592316006702 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 592316006703 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 592316006704 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 592316006705 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 592316006706 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316006707 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316006708 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316006709 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592316006710 dimerization interface [polypeptide binding]; other site 592316006711 agmatinase; Region: agmatinase; TIGR01230 592316006712 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 592316006713 oligomer interface [polypeptide binding]; other site 592316006714 active site 592316006715 Mn binding site [ion binding]; other site 592316006716 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316006717 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316006718 substrate binding pocket [chemical binding]; other site 592316006719 membrane-bound complex binding site; other site 592316006720 hinge residues; other site 592316006721 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316006722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316006723 dimer interface [polypeptide binding]; other site 592316006724 conserved gate region; other site 592316006725 putative PBP binding loops; other site 592316006726 ABC-ATPase subunit interface; other site 592316006727 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316006728 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316006729 Walker A/P-loop; other site 592316006730 ATP binding site [chemical binding]; other site 592316006731 Q-loop/lid; other site 592316006732 ABC transporter signature motif; other site 592316006733 Walker B; other site 592316006734 D-loop; other site 592316006735 H-loop/switch region; other site 592316006736 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316006737 agmatinase; Region: agmatinase; TIGR01230 592316006738 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 592316006739 oligomer interface [polypeptide binding]; other site 592316006740 active site 592316006741 Mn binding site [ion binding]; other site 592316006742 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 592316006743 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 592316006744 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592316006745 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 592316006746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316006747 Coenzyme A binding pocket [chemical binding]; other site 592316006748 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 592316006749 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316006750 Coenzyme A binding pocket [chemical binding]; other site 592316006751 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 592316006752 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 592316006753 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 592316006754 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 592316006755 putative active site; other site 592316006756 catalytic residue [active] 592316006757 Ectoine synthase; Region: Ectoine_synth; cl17598 592316006758 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 592316006759 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 592316006760 active site 592316006761 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 592316006762 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 592316006763 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 592316006764 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 592316006765 active site 592316006766 Zn binding site [ion binding]; other site 592316006767 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 592316006768 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 592316006769 XdhC Rossmann domain; Region: XdhC_C; pfam13478 592316006770 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 592316006771 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 592316006772 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 592316006773 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 592316006774 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 592316006775 catalytic loop [active] 592316006776 iron binding site [ion binding]; other site 592316006777 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 592316006778 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 592316006779 guanine deaminase; Provisional; Region: PRK09228 592316006780 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 592316006781 active site 592316006782 malonic semialdehyde reductase; Provisional; Region: PRK10538 592316006783 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 592316006784 putative NAD(P) binding site [chemical binding]; other site 592316006785 homodimer interface [polypeptide binding]; other site 592316006786 homotetramer interface [polypeptide binding]; other site 592316006787 active site 592316006788 hypothetical protein; Provisional; Region: PRK02237 592316006789 hypothetical protein; Provisional; Region: PRK13659 592316006790 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 592316006791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316006792 putative substrate translocation pore; other site 592316006793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316006794 dimer interface [polypeptide binding]; other site 592316006795 conserved gate region; other site 592316006796 putative PBP binding loops; other site 592316006797 ABC-ATPase subunit interface; other site 592316006798 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 592316006799 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 592316006800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316006801 dimer interface [polypeptide binding]; other site 592316006802 conserved gate region; other site 592316006803 ABC-ATPase subunit interface; other site 592316006804 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 592316006805 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 592316006806 Walker A/P-loop; other site 592316006807 ATP binding site [chemical binding]; other site 592316006808 Q-loop/lid; other site 592316006809 ABC transporter signature motif; other site 592316006810 Walker B; other site 592316006811 D-loop; other site 592316006812 H-loop/switch region; other site 592316006813 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 592316006814 xanthine permease; Region: pbuX; TIGR03173 592316006815 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 592316006816 AAA domain; Region: AAA_26; pfam13500 592316006817 MarR family; Region: MarR_2; cl17246 592316006818 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 592316006819 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 592316006820 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316006821 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316006822 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 592316006823 dimerization interface [polypeptide binding]; other site 592316006824 substrate binding pocket [chemical binding]; other site 592316006825 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 592316006826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316006827 putative substrate translocation pore; other site 592316006828 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 592316006829 putative arabinose transporter; Provisional; Region: PRK03545 592316006830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316006831 putative substrate translocation pore; other site 592316006832 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 592316006833 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592316006834 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316006835 Domain of unknown function (DUF718); Region: DUF718; cl01281 592316006836 rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634 592316006837 intersubunit interface [polypeptide binding]; other site 592316006838 active site 592316006839 Zn2+ binding site [ion binding]; other site 592316006840 L-rhamnose isomerase; Provisional; Region: PRK01076 592316006841 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 592316006842 N- and C-terminal domain interface [polypeptide binding]; other site 592316006843 active site 592316006844 putative catalytic site [active] 592316006845 metal binding site [ion binding]; metal-binding site 592316006846 ATP binding site [chemical binding]; other site 592316006847 rhamnulokinase; Provisional; Region: rhaB; PRK10640 592316006848 carbohydrate binding site [chemical binding]; other site 592316006849 transcriptional activator RhaS; Provisional; Region: PRK13503 592316006850 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 592316006851 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316006852 transcriptional activator RhaR; Provisional; Region: PRK13501 592316006853 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 592316006854 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316006855 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 592316006856 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 592316006857 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 592316006858 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 592316006859 NAD binding site [chemical binding]; other site 592316006860 catalytic residues [active] 592316006861 substrate binding site [chemical binding]; other site 592316006862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316006863 metabolite-proton symporter; Region: 2A0106; TIGR00883 592316006864 putative substrate translocation pore; other site 592316006865 hypothetical protein; Provisional; Region: PRK07079 592316006866 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 592316006867 metal binding site [ion binding]; metal-binding site 592316006868 putative dimer interface [polypeptide binding]; other site 592316006869 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316006870 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316006871 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316006872 dimerization interface [polypeptide binding]; other site 592316006873 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592316006874 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 592316006875 peptide binding site [polypeptide binding]; other site 592316006876 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 592316006877 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 592316006878 metal binding site [ion binding]; metal-binding site 592316006879 dimer interface [polypeptide binding]; other site 592316006880 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 592316006881 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316006882 substrate binding pocket [chemical binding]; other site 592316006883 membrane-bound complex binding site; other site 592316006884 hinge residues; other site 592316006885 putative aminotransferase; Provisional; Region: PRK12414 592316006886 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316006887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316006888 homodimer interface [polypeptide binding]; other site 592316006889 catalytic residue [active] 592316006890 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 592316006891 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316006892 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316006893 dimerization interface [polypeptide binding]; other site 592316006894 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 592316006895 HAMP domain; Region: HAMP; pfam00672 592316006896 dimerization interface [polypeptide binding]; other site 592316006897 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592316006898 dimer interface [polypeptide binding]; other site 592316006899 putative CheW interface [polypeptide binding]; other site 592316006900 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 592316006901 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 592316006902 substrate binding pocket [chemical binding]; other site 592316006903 catalytic triad [active] 592316006904 Predicted membrane protein [Function unknown]; Region: COG2259 592316006905 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 592316006906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 592316006907 benzoate transport; Region: 2A0115; TIGR00895 592316006908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316006909 putative substrate translocation pore; other site 592316006910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316006911 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 592316006912 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316006913 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316006914 dimerization interface [polypeptide binding]; other site 592316006915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 592316006916 Smr domain; Region: Smr; pfam01713 592316006917 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 592316006918 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 592316006919 ligand binding site [chemical binding]; other site 592316006920 flexible hinge region; other site 592316006921 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 592316006922 putative switch regulator; other site 592316006923 non-specific DNA interactions [nucleotide binding]; other site 592316006924 DNA binding site [nucleotide binding] 592316006925 sequence specific DNA binding site [nucleotide binding]; other site 592316006926 putative cAMP binding site [chemical binding]; other site 592316006927 universal stress protein UspE; Provisional; Region: PRK11175 592316006928 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 592316006929 Ligand Binding Site [chemical binding]; other site 592316006930 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 592316006931 Ligand Binding Site [chemical binding]; other site 592316006932 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 592316006933 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 592316006934 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 592316006935 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 592316006936 ligand binding site [chemical binding]; other site 592316006937 homodimer interface [polypeptide binding]; other site 592316006938 NAD(P) binding site [chemical binding]; other site 592316006939 trimer interface B [polypeptide binding]; other site 592316006940 trimer interface A [polypeptide binding]; other site 592316006941 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 592316006942 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 592316006943 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 592316006944 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 592316006945 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 592316006946 Spore germination protein; Region: Spore_permease; cl17796 592316006947 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 592316006948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316006949 active site 592316006950 phosphorylation site [posttranslational modification] 592316006951 intermolecular recognition site; other site 592316006952 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592316006953 DNA binding site [nucleotide binding] 592316006954 sensor protein RstB; Provisional; Region: PRK10604 592316006955 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592316006956 dimerization interface [polypeptide binding]; other site 592316006957 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316006958 dimer interface [polypeptide binding]; other site 592316006959 phosphorylation site [posttranslational modification] 592316006960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316006961 ATP binding site [chemical binding]; other site 592316006962 Mg2+ binding site [ion binding]; other site 592316006963 G-X-G motif; other site 592316006964 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 592316006965 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 592316006966 active site 592316006967 Zn binding site [ion binding]; other site 592316006968 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 592316006969 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 592316006970 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592316006971 ATP binding site [chemical binding]; other site 592316006972 putative Mg++ binding site [ion binding]; other site 592316006973 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592316006974 nucleotide binding region [chemical binding]; other site 592316006975 ATP-binding site [chemical binding]; other site 592316006976 Helicase associated domain (HA2); Region: HA2; pfam04408 592316006977 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 592316006978 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 592316006979 azoreductase; Reviewed; Region: PRK00170 592316006980 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592316006981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 592316006982 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 592316006983 hypothetical protein; Provisional; Region: PRK10695 592316006984 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 592316006985 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 592316006986 putative ligand binding site [chemical binding]; other site 592316006987 putative NAD binding site [chemical binding]; other site 592316006988 catalytic site [active] 592316006989 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 592316006990 Domain of unknown function (DUF333); Region: DUF333; pfam03891 592316006991 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 592316006992 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 592316006993 dimer interface [polypeptide binding]; other site 592316006994 PYR/PP interface [polypeptide binding]; other site 592316006995 TPP binding site [chemical binding]; other site 592316006996 substrate binding site [chemical binding]; other site 592316006997 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 592316006998 Domain of unknown function; Region: EKR; smart00890 592316006999 4Fe-4S binding domain; Region: Fer4_6; pfam12837 592316007000 4Fe-4S binding domain; Region: Fer4; pfam00037 592316007001 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 592316007002 TPP-binding site [chemical binding]; other site 592316007003 hypothetical protein; Provisional; Region: PRK06185 592316007004 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592316007005 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 592316007006 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 592316007007 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316007008 N-terminal plug; other site 592316007009 ligand-binding site [chemical binding]; other site 592316007010 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 592316007011 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 592316007012 Ligand Binding Site [chemical binding]; other site 592316007013 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 592316007014 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 592316007015 Cl binding site [ion binding]; other site 592316007016 oligomer interface [polypeptide binding]; other site 592316007017 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 592316007018 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 592316007019 peptide binding site [polypeptide binding]; other site 592316007020 murein peptide amidase A; Provisional; Region: PRK10602 592316007021 active site 592316007022 Zn binding site [ion binding]; other site 592316007023 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 592316007024 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 592316007025 active site 592316007026 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 592316007027 dimer interface [polypeptide binding]; other site 592316007028 catalytic triad [active] 592316007029 peroxidatic and resolving cysteines [active] 592316007030 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 592316007031 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 592316007032 putative aromatic amino acid binding site; other site 592316007033 PAS domain; Region: PAS; smart00091 592316007034 putative active site [active] 592316007035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316007036 Walker A motif; other site 592316007037 ATP binding site [chemical binding]; other site 592316007038 Walker B motif; other site 592316007039 arginine finger; other site 592316007040 hypothetical protein; Provisional; Region: PRK05415 592316007041 Domain of unknown function (DUF697); Region: DUF697; cl12064 592316007042 Predicted ATPase [General function prediction only]; Region: COG3106 592316007043 Phage shock protein PspD (Phageshock_PspD); Region: Phageshock_PspD; cl11512 592316007044 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 592316007045 phage shock protein C; Region: phageshock_pspC; TIGR02978 592316007046 phage shock protein B; Provisional; Region: pspB; PRK09458 592316007047 phage shock protein PspA; Provisional; Region: PRK10698 592316007048 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 592316007049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316007050 Walker A motif; other site 592316007051 ATP binding site [chemical binding]; other site 592316007052 Walker B motif; other site 592316007053 arginine finger; other site 592316007054 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 592316007055 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 592316007056 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 592316007057 peptide binding site [polypeptide binding]; other site 592316007058 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 592316007059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316007060 dimer interface [polypeptide binding]; other site 592316007061 conserved gate region; other site 592316007062 putative PBP binding loops; other site 592316007063 ABC-ATPase subunit interface; other site 592316007064 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 592316007065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316007066 dimer interface [polypeptide binding]; other site 592316007067 conserved gate region; other site 592316007068 putative PBP binding loops; other site 592316007069 ABC-ATPase subunit interface; other site 592316007070 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 592316007071 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316007072 Walker A/P-loop; other site 592316007073 ATP binding site [chemical binding]; other site 592316007074 Q-loop/lid; other site 592316007075 ABC transporter signature motif; other site 592316007076 Walker B; other site 592316007077 D-loop; other site 592316007078 H-loop/switch region; other site 592316007079 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316007080 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 592316007081 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316007082 Walker A/P-loop; other site 592316007083 ATP binding site [chemical binding]; other site 592316007084 Q-loop/lid; other site 592316007085 ABC transporter signature motif; other site 592316007086 Walker B; other site 592316007087 D-loop; other site 592316007088 H-loop/switch region; other site 592316007089 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 592316007090 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 592316007091 NAD binding site [chemical binding]; other site 592316007092 homotetramer interface [polypeptide binding]; other site 592316007093 homodimer interface [polypeptide binding]; other site 592316007094 substrate binding site [chemical binding]; other site 592316007095 active site 592316007096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 592316007097 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 592316007098 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 592316007099 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316007100 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316007101 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592316007102 dimerization interface [polypeptide binding]; other site 592316007103 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 592316007104 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 592316007105 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 592316007106 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 592316007107 active site turn [active] 592316007108 phosphorylation site [posttranslational modification] 592316007109 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 592316007110 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 592316007111 putative molybdopterin cofactor binding site [chemical binding]; other site 592316007112 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 592316007113 putative molybdopterin cofactor binding site; other site 592316007114 exoribonuclease II; Provisional; Region: PRK05054 592316007115 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 592316007116 RNB domain; Region: RNB; pfam00773 592316007117 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 592316007118 carbon starvation protein A; Provisional; Region: PRK15015 592316007119 Carbon starvation protein CstA; Region: CstA; pfam02554 592316007120 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 592316007121 Uncharacterized small protein [Function unknown]; Region: COG2879 592316007122 RNase II stability modulator; Provisional; Region: PRK10060 592316007123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592316007124 putative active site [active] 592316007125 heme pocket [chemical binding]; other site 592316007126 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316007127 metal binding site [ion binding]; metal-binding site 592316007128 active site 592316007129 I-site; other site 592316007130 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592316007131 enoyl-CoA hydratase; Validated; Region: PRK08788 592316007132 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 592316007133 substrate binding site [chemical binding]; other site 592316007134 oxyanion hole (OAH) forming residues; other site 592316007135 trimer interface [polypeptide binding]; other site 592316007136 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 592316007137 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 592316007138 intersubunit interface [polypeptide binding]; other site 592316007139 active site 592316007140 Zn2+ binding site [ion binding]; other site 592316007141 lipoprotein; Provisional; Region: PRK10540 592316007142 translation initiation factor Sui1; Validated; Region: PRK06824 592316007143 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 592316007144 putative rRNA binding site [nucleotide binding]; other site 592316007145 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 592316007146 active site 592316007147 dimer interface [polypeptide binding]; other site 592316007148 tetratricopeptide repeat protein; Provisional; Region: PRK11788 592316007149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 592316007150 TPR motif; other site 592316007151 binding surface 592316007152 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 592316007153 TPR motif; other site 592316007154 binding surface 592316007155 Predicted membrane protein [Function unknown]; Region: COG3771 592316007156 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 592316007157 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 592316007158 active site 592316007159 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 592316007160 dimerization interface [polypeptide binding]; other site 592316007161 active site 592316007162 aconitate hydratase; Validated; Region: PRK09277 592316007163 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 592316007164 substrate binding site [chemical binding]; other site 592316007165 ligand binding site [chemical binding]; other site 592316007166 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 592316007167 substrate binding site [chemical binding]; other site 592316007168 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 592316007169 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316007170 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 592316007171 substrate binding site [chemical binding]; other site 592316007172 putative dimerization interface [polypeptide binding]; other site 592316007173 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 592316007174 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 592316007175 active site 592316007176 interdomain interaction site; other site 592316007177 putative metal-binding site [ion binding]; other site 592316007178 nucleotide binding site [chemical binding]; other site 592316007179 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 592316007180 domain I; other site 592316007181 DNA binding groove [nucleotide binding] 592316007182 phosphate binding site [ion binding]; other site 592316007183 domain II; other site 592316007184 domain III; other site 592316007185 nucleotide binding site [chemical binding]; other site 592316007186 catalytic site [active] 592316007187 domain IV; other site 592316007188 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 592316007189 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 592316007190 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 592316007191 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 592316007192 Protein of unknown function (DUF2498); Region: DUF2498; cl11671 592316007193 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 592316007194 putative inner membrane peptidase; Provisional; Region: PRK11778 592316007195 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 592316007196 tandem repeat interface [polypeptide binding]; other site 592316007197 oligomer interface [polypeptide binding]; other site 592316007198 active site residues [active] 592316007199 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 592316007200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316007201 NAD(P) binding site [chemical binding]; other site 592316007202 active site 592316007203 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 592316007204 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 592316007205 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 592316007206 homodimer interface [polypeptide binding]; other site 592316007207 Walker A motif; other site 592316007208 ATP binding site [chemical binding]; other site 592316007209 hydroxycobalamin binding site [chemical binding]; other site 592316007210 Walker B motif; other site 592316007211 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 592316007212 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592316007213 RNA binding surface [nucleotide binding]; other site 592316007214 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 592316007215 probable active site [active] 592316007216 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 592316007217 hypothetical protein; Provisional; Region: PRK11630 592316007218 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 592316007219 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 592316007220 active site 592316007221 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 592316007222 anthranilate synthase component I; Provisional; Region: PRK13564 592316007223 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 592316007224 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 592316007225 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 592316007226 Glutamine amidotransferase class-I; Region: GATase; pfam00117 592316007227 glutamine binding [chemical binding]; other site 592316007228 catalytic triad [active] 592316007229 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 592316007230 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 592316007231 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 592316007232 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 592316007233 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 592316007234 active site 592316007235 ribulose/triose binding site [chemical binding]; other site 592316007236 phosphate binding site [ion binding]; other site 592316007237 substrate (anthranilate) binding pocket [chemical binding]; other site 592316007238 product (indole) binding pocket [chemical binding]; other site 592316007239 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 592316007240 active site 592316007241 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 592316007242 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 592316007243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316007244 catalytic residue [active] 592316007245 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 592316007246 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 592316007247 substrate binding site [chemical binding]; other site 592316007248 active site 592316007249 catalytic residues [active] 592316007250 heterodimer interface [polypeptide binding]; other site 592316007251 BON domain; Region: BON; pfam04972 592316007252 Chitin binding domain; Region: Chitin_bind_3; pfam03067 592316007253 putative fimbrial chaperone protein; Provisional; Region: PRK09918 592316007254 outer membrane protein W; Provisional; Region: PRK10959 592316007255 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 592316007256 hypothetical protein; Provisional; Region: PRK02868 592316007257 intracellular septation protein A; Reviewed; Region: PRK00259 592316007258 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 592316007259 transport protein TonB; Provisional; Region: PRK10819 592316007260 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 592316007261 YciI-like protein; Reviewed; Region: PRK11370 592316007262 DinI-like family; Region: DinI; cl11630 592316007263 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 592316007264 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 592316007265 Phage-related protein, tail component [Function unknown]; Region: COG4733 592316007266 Putative phage tail protein; Region: Phage-tail_3; pfam13550 592316007267 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 592316007268 Phage-related protein, tail component [Function unknown]; Region: COG4723 592316007269 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 592316007270 MPN+ (JAMM) motif; other site 592316007271 Zinc-binding site [ion binding]; other site 592316007272 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 592316007273 NlpC/P60 family; Region: NLPC_P60; cl17555 592316007274 Phage-related protein [Function unknown]; Region: gp18; COG4672 592316007275 Phage minor tail protein; Region: Phage_min_tail; pfam05939 592316007276 phosphodiesterase; Provisional; Region: PRK12704 592316007277 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 592316007278 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 592316007279 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 592316007280 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 592316007281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 592316007282 Terminase-like family; Region: Terminase_6; pfam03237 592316007283 Uncharacterized conserved protein [Function unknown]; Region: COG5323 592316007284 Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045 592316007285 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 592316007286 Protein of unknown function (DUF1378); Region: DUF1378; pfam07125 592316007287 Predicted chitinase [General function prediction only]; Region: COG3179 592316007288 catalytic residue [active] 592316007289 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 592316007290 Antitermination protein; Region: Antiterm; pfam03589 592316007291 Antitermination protein; Region: Antiterm; pfam03589 592316007292 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 592316007293 replicative DNA helicase; Region: DnaB; TIGR00665 592316007294 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 592316007295 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 592316007296 Walker A motif; other site 592316007297 ATP binding site [chemical binding]; other site 592316007298 Walker B motif; other site 592316007299 DNA binding loops [nucleotide binding] 592316007300 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 592316007301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316007302 non-specific DNA binding site [nucleotide binding]; other site 592316007303 salt bridge; other site 592316007304 sequence-specific DNA binding site [nucleotide binding]; other site 592316007305 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 592316007306 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 592316007307 Catalytic site [active] 592316007308 exodeoxyribonuclease X; Provisional; Region: PRK07983 592316007309 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 592316007310 active site 592316007311 catalytic site [active] 592316007312 substrate binding site [chemical binding]; other site 592316007313 AAA domain; Region: AAA_22; pfam13401 592316007314 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 592316007315 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 592316007316 non-specific DNA binding site [nucleotide binding]; other site 592316007317 salt bridge; other site 592316007318 sequence-specific DNA binding site [nucleotide binding]; other site 592316007319 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440 592316007320 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 592316007321 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 592316007322 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 592316007323 cofactor binding site; other site 592316007324 DNA binding site [nucleotide binding] 592316007325 substrate interaction site [chemical binding]; other site 592316007326 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 592316007327 integrase; Provisional; Region: PRK09692 592316007328 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 592316007329 active site 592316007330 Int/Topo IB signature motif; other site 592316007331 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 592316007332 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 592316007333 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 592316007334 putative active site [active] 592316007335 catalytic site [active] 592316007336 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 592316007337 putative active site [active] 592316007338 catalytic site [active] 592316007339 dsDNA-mimic protein; Reviewed; Region: PRK05094 592316007340 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 592316007341 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316007342 Walker A/P-loop; other site 592316007343 ATP binding site [chemical binding]; other site 592316007344 Q-loop/lid; other site 592316007345 ABC transporter signature motif; other site 592316007346 Walker B; other site 592316007347 D-loop; other site 592316007348 H-loop/switch region; other site 592316007349 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 592316007350 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 592316007351 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316007352 Walker A/P-loop; other site 592316007353 ATP binding site [chemical binding]; other site 592316007354 Q-loop/lid; other site 592316007355 ABC transporter signature motif; other site 592316007356 Walker B; other site 592316007357 D-loop; other site 592316007358 H-loop/switch region; other site 592316007359 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 592316007360 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 592316007361 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 592316007362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316007363 dimer interface [polypeptide binding]; other site 592316007364 conserved gate region; other site 592316007365 putative PBP binding loops; other site 592316007366 ABC-ATPase subunit interface; other site 592316007367 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 592316007368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316007369 dimer interface [polypeptide binding]; other site 592316007370 conserved gate region; other site 592316007371 putative PBP binding loops; other site 592316007372 ABC-ATPase subunit interface; other site 592316007373 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 592316007374 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 592316007375 peptide binding site [polypeptide binding]; other site 592316007376 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 592316007377 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 592316007378 peptide binding site [polypeptide binding]; other site 592316007379 hypothetical protein; Provisional; Region: PRK11111 592316007380 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 592316007381 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 592316007382 putative catalytic cysteine [active] 592316007383 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 592316007384 putative active site [active] 592316007385 metal binding site [ion binding]; metal-binding site 592316007386 thymidine kinase; Provisional; Region: PRK04296 592316007387 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 592316007388 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 592316007389 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 592316007390 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 592316007391 putative NAD(P) binding site [chemical binding]; other site 592316007392 active site 592316007393 putative substrate binding site [chemical binding]; other site 592316007394 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 592316007395 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 592316007396 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 592316007397 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 592316007398 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 592316007399 active site 592316007400 tetramer interface; other site 592316007401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316007402 active site 592316007403 response regulator of RpoS; Provisional; Region: PRK10693 592316007404 phosphorylation site [posttranslational modification] 592316007405 intermolecular recognition site; other site 592316007406 dimerization interface [polypeptide binding]; other site 592316007407 hypothetical protein; Provisional; Region: PRK10279 592316007408 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 592316007409 active site 592316007410 nucleophile elbow; other site 592316007411 hypothetical protein; Provisional; Region: PRK01617 592316007412 SEC-C motif; Region: SEC-C; pfam02810 592316007413 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 592316007414 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 592316007415 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 592316007416 putative active site [active] 592316007417 putative substrate binding site [chemical binding]; other site 592316007418 putative cosubstrate binding site; other site 592316007419 catalytic site [active] 592316007420 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316007421 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316007422 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316007423 dimerization interface [polypeptide binding]; other site 592316007424 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 592316007425 putative catalytic site [active] 592316007426 putative phosphate binding site [ion binding]; other site 592316007427 active site 592316007428 metal binding site A [ion binding]; metal-binding site 592316007429 DNA binding site [nucleotide binding] 592316007430 putative AP binding site [nucleotide binding]; other site 592316007431 putative metal binding site B [ion binding]; other site 592316007432 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 592316007433 DNA topoisomerase III; Provisional; Region: PRK07726 592316007434 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 592316007435 active site 592316007436 putative interdomain interaction site [polypeptide binding]; other site 592316007437 putative metal-binding site [ion binding]; other site 592316007438 putative nucleotide binding site [chemical binding]; other site 592316007439 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 592316007440 domain I; other site 592316007441 DNA binding groove [nucleotide binding] 592316007442 phosphate binding site [ion binding]; other site 592316007443 domain II; other site 592316007444 domain III; other site 592316007445 nucleotide binding site [chemical binding]; other site 592316007446 catalytic site [active] 592316007447 domain IV; other site 592316007448 selenophosphate synthetase; Provisional; Region: PRK00943 592316007449 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 592316007450 dimerization interface [polypeptide binding]; other site 592316007451 putative ATP binding site [chemical binding]; other site 592316007452 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 592316007453 putative FMN binding site [chemical binding]; other site 592316007454 protease 4; Provisional; Region: PRK10949 592316007455 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 592316007456 tandem repeat interface [polypeptide binding]; other site 592316007457 oligomer interface [polypeptide binding]; other site 592316007458 active site residues [active] 592316007459 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 592316007460 tandem repeat interface [polypeptide binding]; other site 592316007461 oligomer interface [polypeptide binding]; other site 592316007462 active site residues [active] 592316007463 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 592316007464 active site 592316007465 homodimer interface [polypeptide binding]; other site 592316007466 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 592316007467 Isochorismatase family; Region: Isochorismatase; pfam00857 592316007468 catalytic triad [active] 592316007469 metal binding site [ion binding]; metal-binding site 592316007470 conserved cis-peptide bond; other site 592316007471 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 592316007472 methionine sulfoxide reductase B; Provisional; Region: PRK00222 592316007473 SelR domain; Region: SelR; pfam01641 592316007474 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 592316007475 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 592316007476 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 592316007477 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 592316007478 active site 592316007479 phosphate binding residues; other site 592316007480 catalytic residues [active] 592316007481 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592316007482 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592316007483 active site 592316007484 catalytic tetrad [active] 592316007485 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 592316007486 PrkA family serine protein kinase; Provisional; Region: PRK15455 592316007487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316007488 Walker A motif; other site 592316007489 ATP binding site [chemical binding]; other site 592316007490 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 592316007491 hypothetical protein; Provisional; Region: PRK05325 592316007492 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 592316007493 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 592316007494 TrkA-C domain; Region: TrkA_C; pfam02080 592316007495 Transporter associated domain; Region: CorC_HlyC; smart01091 592316007496 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 592316007497 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 592316007498 Bacterial sugar transferase; Region: Bac_transf; pfam02397 592316007499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316007500 putative substrate translocation pore; other site 592316007501 alanine racemase; Reviewed; Region: dadX; PRK03646 592316007502 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 592316007503 active site 592316007504 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 592316007505 substrate binding site [chemical binding]; other site 592316007506 catalytic residues [active] 592316007507 dimer interface [polypeptide binding]; other site 592316007508 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 592316007509 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592316007510 SpoVR family protein; Provisional; Region: PRK11767 592316007511 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 592316007512 fatty acid metabolism regulator; Provisional; Region: PRK04984 592316007513 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316007514 DNA-binding site [nucleotide binding]; DNA binding site 592316007515 FadR C-terminal domain; Region: FadR_C; pfam07840 592316007516 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 592316007517 disulfide bond formation protein B; Provisional; Region: PRK01749 592316007518 hypothetical protein; Provisional; Region: PRK05170 592316007519 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 592316007520 hypothetical protein; Provisional; Region: PRK10691 592316007521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 592316007522 septum formation inhibitor; Reviewed; Region: minC; PRK03511 592316007523 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 592316007524 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 592316007525 cell division inhibitor MinD; Provisional; Region: PRK10818 592316007526 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 592316007527 Switch I; other site 592316007528 Switch II; other site 592316007529 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 592316007530 ribonuclease D; Provisional; Region: PRK10829 592316007531 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 592316007532 catalytic site [active] 592316007533 putative active site [active] 592316007534 putative substrate binding site [chemical binding]; other site 592316007535 HRDC domain; Region: HRDC; cl02578 592316007536 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 592316007537 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 592316007538 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 592316007539 acyl-activating enzyme (AAE) consensus motif; other site 592316007540 putative AMP binding site [chemical binding]; other site 592316007541 putative active site [active] 592316007542 putative CoA binding site [chemical binding]; other site 592316007543 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 592316007544 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 592316007545 Glycoprotease family; Region: Peptidase_M22; pfam00814 592316007546 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 592316007547 DEAD/DEAH box helicase; Region: DEAD; pfam00270 592316007548 ATP binding site [chemical binding]; other site 592316007549 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 592316007550 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 592316007551 homotrimer interaction site [polypeptide binding]; other site 592316007552 putative active site [active] 592316007553 hypothetical protein; Provisional; Region: PRK05114 592316007554 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 592316007555 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 592316007556 chorismate binding enzyme; Region: Chorismate_bind; cl10555 592316007557 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 592316007558 putative active site [active] 592316007559 putative CoA binding site [chemical binding]; other site 592316007560 nudix motif; other site 592316007561 metal binding site [ion binding]; metal-binding site 592316007562 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 592316007563 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 592316007564 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 592316007565 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 592316007566 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 592316007567 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592316007568 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 592316007569 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 592316007570 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 592316007571 Transporter associated domain; Region: CorC_HlyC; smart01091 592316007572 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 592316007573 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 592316007574 active pocket/dimerization site; other site 592316007575 active site 592316007576 phosphorylation site [posttranslational modification] 592316007577 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 592316007578 active site 592316007579 phosphorylation site [posttranslational modification] 592316007580 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 592316007581 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 592316007582 hypothetical protein; Provisional; Region: PRK02913 592316007583 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 592316007584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316007585 S-adenosylmethionine binding site [chemical binding]; other site 592316007586 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 592316007587 DNA-binding site [nucleotide binding]; DNA binding site 592316007588 RNA-binding motif; other site 592316007589 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 592316007590 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 592316007591 YebO-like protein; Region: YebO; pfam13974 592316007592 YobH-like protein; Region: YobH; pfam13996 592316007593 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 592316007594 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 592316007595 Bacterial transcriptional regulator; Region: IclR; pfam01614 592316007596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316007597 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592316007598 putative substrate translocation pore; other site 592316007599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316007600 heat shock protein HtpX; Provisional; Region: PRK05457 592316007601 carboxy-terminal protease; Provisional; Region: PRK11186 592316007602 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 592316007603 protein binding site [polypeptide binding]; other site 592316007604 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 592316007605 Catalytic dyad [active] 592316007606 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 592316007607 ProP expression regulator; Provisional; Region: PRK04950 592316007608 ProQ/FINO family; Region: ProQ; pfam04352 592316007609 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 592316007610 GAF domain; Region: GAF_2; pfam13185 592316007611 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 592316007612 Paraquat-inducible protein A; Region: PqiA; pfam04403 592316007613 Paraquat-inducible protein A; Region: PqiA; pfam04403 592316007614 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 592316007615 mce related protein; Region: MCE; pfam02470 592316007616 mce related protein; Region: MCE; pfam02470 592316007617 mce related protein; Region: MCE; pfam02470 592316007618 mce related protein; Region: MCE; pfam02470 592316007619 mce related protein; Region: MCE; pfam02470 592316007620 mce related protein; Region: MCE; pfam02470 592316007621 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 592316007622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316007623 S-adenosylmethionine binding site [chemical binding]; other site 592316007624 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 592316007625 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 592316007626 active site 592316007627 metal binding site [ion binding]; metal-binding site 592316007628 Protein of unknown function (DUF616); Region: DUF616; pfam04765 592316007629 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 592316007630 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 592316007631 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 592316007632 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 592316007633 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 592316007634 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 592316007635 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 592316007636 DksA-like zinc finger domain containing protein; Region: PHA00080 592316007637 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 592316007638 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 592316007639 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 592316007640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316007641 S-adenosylmethionine binding site [chemical binding]; other site 592316007642 portal vertex protein; Provisional; Region: Q; PHA02536 592316007643 Phage portal protein; Region: Phage_portal; pfam04860 592316007644 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 592316007645 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 592316007646 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 592316007647 baseplate wedge subunit; Provisional; Region: W; PHA02516 592316007648 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 592316007649 non-specific DNA binding site [nucleotide binding]; other site 592316007650 salt bridge; other site 592316007651 sequence-specific DNA binding site [nucleotide binding]; other site 592316007652 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 592316007653 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316007654 sequence-specific DNA binding site [nucleotide binding]; other site 592316007655 salt bridge; other site 592316007656 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 592316007657 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 592316007658 CopC domain; Region: CopC; pfam04234 592316007659 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 592316007660 exodeoxyribonuclease X; Provisional; Region: PRK07983 592316007661 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 592316007662 active site 592316007663 catalytic site [active] 592316007664 substrate binding site [chemical binding]; other site 592316007665 protease 2; Provisional; Region: PRK10115 592316007666 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592316007667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 592316007668 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 592316007669 putative metal binding site [ion binding]; other site 592316007670 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 592316007671 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592316007672 ATP-grasp domain; Region: ATP-grasp; pfam02222 592316007673 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 592316007674 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 592316007675 active site 592316007676 intersubunit interface [polypeptide binding]; other site 592316007677 catalytic residue [active] 592316007678 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 592316007679 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 592316007680 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 592316007681 dimerization domain swap beta strand [polypeptide binding]; other site 592316007682 regulatory protein interface [polypeptide binding]; other site 592316007683 active site 592316007684 regulatory phosphorylation site [posttranslational modification]; other site 592316007685 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 592316007686 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 592316007687 DAK2 domain; Region: Dak2; cl03685 592316007688 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 592316007689 Dak1 domain; Region: Dak1; pfam02733 592316007690 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 592316007691 amphipathic channel; other site 592316007692 Asn-Pro-Ala signature motifs; other site 592316007693 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 592316007694 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592316007695 putative active site [active] 592316007696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316007697 Walker A motif; other site 592316007698 ATP binding site [chemical binding]; other site 592316007699 Walker B motif; other site 592316007700 arginine finger; other site 592316007701 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 592316007702 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 592316007703 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 592316007704 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 592316007705 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 592316007706 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 592316007707 putative active site [active] 592316007708 pyruvate kinase; Provisional; Region: PRK05826 592316007709 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 592316007710 domain interfaces; other site 592316007711 active site 592316007712 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 592316007713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316007714 putative substrate translocation pore; other site 592316007715 outer membrane protease; Reviewed; Region: PRK10993 592316007716 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 592316007717 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 592316007718 putative acyl-acceptor binding pocket; other site 592316007719 putative peptidase; Provisional; Region: PRK11649 592316007720 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 592316007721 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592316007722 Peptidase family M23; Region: Peptidase_M23; pfam01551 592316007723 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 592316007724 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 592316007725 metal binding site [ion binding]; metal-binding site 592316007726 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 592316007727 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 592316007728 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 592316007729 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592316007730 dimer interface [polypeptide binding]; other site 592316007731 ABC-ATPase subunit interface; other site 592316007732 putative PBP binding regions; other site 592316007733 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 592316007734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316007735 Walker A motif; other site 592316007736 ATP binding site [chemical binding]; other site 592316007737 Walker B motif; other site 592316007738 arginine finger; other site 592316007739 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 592316007740 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 592316007741 RuvA N terminal domain; Region: RuvA_N; pfam01330 592316007742 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 592316007743 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 592316007744 active site 592316007745 putative DNA-binding cleft [nucleotide binding]; other site 592316007746 dimer interface [polypeptide binding]; other site 592316007747 hypothetical protein; Validated; Region: PRK00110 592316007748 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 592316007749 nudix motif; other site 592316007750 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 592316007751 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 592316007752 dimer interface [polypeptide binding]; other site 592316007753 anticodon binding site; other site 592316007754 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 592316007755 homodimer interface [polypeptide binding]; other site 592316007756 motif 1; other site 592316007757 active site 592316007758 motif 2; other site 592316007759 GAD domain; Region: GAD; pfam02938 592316007760 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 592316007761 active site 592316007762 motif 3; other site 592316007763 Protein of unknown function DUF72; Region: DUF72; cl00777 592316007764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316007765 S-adenosylmethionine binding site [chemical binding]; other site 592316007766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316007767 S-adenosylmethionine binding site [chemical binding]; other site 592316007768 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 592316007769 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 592316007770 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 592316007771 dimer interface [polypeptide binding]; other site 592316007772 active site 592316007773 metal binding site [ion binding]; metal-binding site 592316007774 copper homeostasis protein CutC; Provisional; Region: PRK11572 592316007775 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 592316007776 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316007777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316007778 homodimer interface [polypeptide binding]; other site 592316007779 catalytic residue [active] 592316007780 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 592316007781 putative metal binding site [ion binding]; other site 592316007782 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 592316007783 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 592316007784 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 592316007785 active site 592316007786 HIGH motif; other site 592316007787 KMSK motif region; other site 592316007788 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 592316007789 tRNA binding surface [nucleotide binding]; other site 592316007790 anticodon binding site; other site 592316007791 Flagellar protein FlhE; Region: FlhE; pfam06366 592316007792 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 592316007793 FHIPEP family; Region: FHIPEP; pfam00771 592316007794 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 592316007795 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 592316007796 hypothetical protein; Provisional; Region: PRK07033 592316007797 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 592316007798 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592316007799 ligand binding site [chemical binding]; other site 592316007800 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 592316007801 G1 box; other site 592316007802 GTP/Mg2+ binding site [chemical binding]; other site 592316007803 Switch I region; other site 592316007804 G3 box; other site 592316007805 Switch II region; other site 592316007806 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 592316007807 G4 box; other site 592316007808 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 592316007809 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 592316007810 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 592316007811 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 592316007812 phosphopeptide binding site; other site 592316007813 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 592316007814 Protein phosphatase 2C; Region: PP2C; pfam00481 592316007815 active site 592316007816 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 592316007817 Catalytic domain of Protein Kinases; Region: PKc; cd00180 592316007818 active site 592316007819 ATP binding site [chemical binding]; other site 592316007820 substrate binding site [chemical binding]; other site 592316007821 activation loop (A-loop); other site 592316007822 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 592316007823 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 592316007824 putative active site pocket [active] 592316007825 dimerization interface [polypeptide binding]; other site 592316007826 putative catalytic residue [active] 592316007827 cation transport regulator; Reviewed; Region: chaB; PRK09582 592316007828 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 592316007829 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 592316007830 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 592316007831 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 592316007832 hypothetical protein; Provisional; Region: PRK10941 592316007833 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 592316007834 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 592316007835 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 592316007836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316007837 peptide chain release factor 1; Validated; Region: prfA; PRK00591 592316007838 This domain is found in peptide chain release factors; Region: PCRF; smart00937 592316007839 RF-1 domain; Region: RF-1; pfam00472 592316007840 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 592316007841 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 592316007842 tRNA; other site 592316007843 putative tRNA binding site [nucleotide binding]; other site 592316007844 putative NADP binding site [chemical binding]; other site 592316007845 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 592316007846 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 592316007847 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 592316007848 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 592316007849 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 592316007850 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 592316007851 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 592316007852 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 592316007853 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592316007854 active site 592316007855 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592316007856 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316007857 metal binding site [ion binding]; metal-binding site 592316007858 active site 592316007859 I-site; other site 592316007860 hypothetical protein; Provisional; Region: PRK10692 592316007861 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 592316007862 putative active site [active] 592316007863 catalytic residue [active] 592316007864 GTP-binding protein YchF; Reviewed; Region: PRK09601 592316007865 YchF GTPase; Region: YchF; cd01900 592316007866 G1 box; other site 592316007867 GTP/Mg2+ binding site [chemical binding]; other site 592316007868 Switch I region; other site 592316007869 G2 box; other site 592316007870 Switch II region; other site 592316007871 G3 box; other site 592316007872 G4 box; other site 592316007873 G5 box; other site 592316007874 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 592316007875 hypothetical protein; Provisional; Region: PRK10236 592316007876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 592316007877 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 592316007878 nudix motif; other site 592316007879 alkaline phosphatase; Provisional; Region: PRK10518 592316007880 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 592316007881 dimer interface [polypeptide binding]; other site 592316007882 active site 592316007883 hypothetical protein; Provisional; Region: PRK10536 592316007884 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 592316007885 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 592316007886 Na binding site [ion binding]; other site 592316007887 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 592316007888 Predicted transcriptional regulator [Transcription]; Region: COG3905 592316007889 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 592316007890 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 592316007891 Glutamate binding site [chemical binding]; other site 592316007892 NAD binding site [chemical binding]; other site 592316007893 catalytic residues [active] 592316007894 Acyltransferase family; Region: Acyl_transf_3; pfam01757 592316007895 Predicted membrane protein [Function unknown]; Region: COG4763 592316007896 Predicted membrane protein [Function unknown]; Region: COG4763 592316007897 Acyltransferase family; Region: Acyl_transf_3; pfam01757 592316007898 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 592316007899 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316007900 Walker A/P-loop; other site 592316007901 ATP binding site [chemical binding]; other site 592316007902 Q-loop/lid; other site 592316007903 ABC transporter signature motif; other site 592316007904 Walker B; other site 592316007905 D-loop; other site 592316007906 H-loop/switch region; other site 592316007907 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316007908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316007909 dimer interface [polypeptide binding]; other site 592316007910 conserved gate region; other site 592316007911 putative PBP binding loops; other site 592316007912 ABC-ATPase subunit interface; other site 592316007913 cystine transporter subunit; Provisional; Region: PRK11260 592316007914 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316007915 substrate binding pocket [chemical binding]; other site 592316007916 membrane-bound complex binding site; other site 592316007917 hinge residues; other site 592316007918 D-cysteine desulfhydrase; Validated; Region: PRK03910 592316007919 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 592316007920 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592316007921 catalytic residue [active] 592316007922 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 592316007923 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 592316007924 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592316007925 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 592316007926 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592316007927 DNA binding residues [nucleotide binding] 592316007928 HNH endonuclease; Region: HNH_2; pfam13391 592316007929 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 592316007930 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 592316007931 trimer interface [polypeptide binding]; other site 592316007932 active site 592316007933 substrate binding site [chemical binding]; other site 592316007934 CoA binding site [chemical binding]; other site 592316007935 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 592316007936 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 592316007937 inhibitor-cofactor binding pocket; inhibition site 592316007938 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316007939 catalytic residue [active] 592316007940 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 592316007941 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592316007942 active site 592316007943 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 592316007944 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 592316007945 active site 592316007946 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 592316007947 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 592316007948 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 592316007949 active site 592316007950 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 592316007951 flagellin; Validated; Region: PRK06819 592316007952 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 592316007953 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 592316007954 flagellar capping protein; Reviewed; Region: fliD; PRK08032 592316007955 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 592316007956 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 592316007957 flagellar protein FliS; Validated; Region: fliS; PRK05685 592316007958 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 592316007959 lipoprotein; Provisional; Region: PRK10397 592316007960 anti-RssB factor; Provisional; Region: PRK10244 592316007961 DinI-like family; Region: DinI; cl11630 592316007962 Sensors of blue-light using FAD; Region: BLUF; smart01034 592316007963 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592316007964 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 592316007965 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 592316007966 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 592316007967 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 592316007968 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 592316007969 FliG C-terminal domain; Region: FliG_C; pfam01706 592316007970 flagellar assembly protein H; Validated; Region: fliH; PRK05687 592316007971 Flagellar assembly protein FliH; Region: FliH; pfam02108 592316007972 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 592316007973 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 592316007974 Walker A motif/ATP binding site; other site 592316007975 Walker B motif; other site 592316007976 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 592316007977 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 592316007978 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 592316007979 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 592316007980 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 592316007981 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 592316007982 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 592316007983 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 592316007984 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 592316007985 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 592316007986 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 592316007987 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 592316007988 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 592316007989 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592316007990 DNA binding residues [nucleotide binding] 592316007991 dimerization interface [polypeptide binding]; other site 592316007992 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 592316007993 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 592316007994 dimer interface [polypeptide binding]; other site 592316007995 ligand binding site [chemical binding]; other site 592316007996 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592316007997 dimerization interface [polypeptide binding]; other site 592316007998 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592316007999 dimer interface [polypeptide binding]; other site 592316008000 putative CheW interface [polypeptide binding]; other site 592316008001 hypothetical protein; Provisional; Region: PRK10708 592316008002 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 592316008003 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316008004 active site 592316008005 motif I; other site 592316008006 motif II; other site 592316008007 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 592316008008 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 592316008009 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316008010 metal binding site [ion binding]; metal-binding site 592316008011 active site 592316008012 I-site; other site 592316008013 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 592316008014 Protein of unknown function (DUF808); Region: DUF808; cl01002 592316008015 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 592316008016 additional DNA contacts [nucleotide binding]; other site 592316008017 mismatch recognition site; other site 592316008018 active site 592316008019 zinc binding site [ion binding]; other site 592316008020 DNA intercalation site [nucleotide binding]; other site 592316008021 DNA cytosine methylase; Provisional; Region: PRK10458 592316008022 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 592316008023 cofactor binding site; other site 592316008024 DNA binding site [nucleotide binding] 592316008025 substrate interaction site [chemical binding]; other site 592316008026 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 592316008027 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 592316008028 dimer interface [polypeptide binding]; other site 592316008029 ligand binding site [chemical binding]; other site 592316008030 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592316008031 dimer interface [polypeptide binding]; other site 592316008032 putative CheW interface [polypeptide binding]; other site 592316008033 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 592316008034 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592316008035 Zn2+ binding site [ion binding]; other site 592316008036 Mg2+ binding site [ion binding]; other site 592316008037 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 592316008038 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 592316008039 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 592316008040 Core-2/I-Branching enzyme; Region: Branch; pfam02485 592316008041 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 592316008042 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 592316008043 active site 592316008044 catalytic residue [active] 592316008045 dimer interface [polypeptide binding]; other site 592316008046 Cordon-bleu domain; Region: Cobl; pfam09469 592316008047 Right handed beta helix region; Region: Beta_helix; pfam13229 592316008048 Protein of unknown function (DUF554); Region: DUF554; pfam04474 592316008049 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 592316008050 Flavoprotein; Region: Flavoprotein; pfam02441 592316008051 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 592316008052 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 592316008053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316008054 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 592316008055 dimerization interface [polypeptide binding]; other site 592316008056 substrate binding pocket [chemical binding]; other site 592316008057 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 592316008058 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 592316008059 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 592316008060 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316008061 N-terminal plug; other site 592316008062 ligand-binding site [chemical binding]; other site 592316008063 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 592316008064 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 592316008065 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 592316008066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316008067 dimer interface [polypeptide binding]; other site 592316008068 conserved gate region; other site 592316008069 putative PBP binding loops; other site 592316008070 ABC-ATPase subunit interface; other site 592316008071 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316008072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316008073 dimer interface [polypeptide binding]; other site 592316008074 conserved gate region; other site 592316008075 putative PBP binding loops; other site 592316008076 ABC-ATPase subunit interface; other site 592316008077 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592316008078 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 592316008079 peptide binding site [polypeptide binding]; other site 592316008080 dimer interface [polypeptide binding]; other site 592316008081 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 592316008082 MarR family; Region: MarR; pfam01047 592316008083 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 592316008084 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316008085 Walker A/P-loop; other site 592316008086 ATP binding site [chemical binding]; other site 592316008087 Q-loop/lid; other site 592316008088 ABC transporter signature motif; other site 592316008089 Walker B; other site 592316008090 D-loop; other site 592316008091 H-loop/switch region; other site 592316008092 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 592316008093 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316008094 Walker A/P-loop; other site 592316008095 ATP binding site [chemical binding]; other site 592316008096 Q-loop/lid; other site 592316008097 ABC transporter signature motif; other site 592316008098 Walker B; other site 592316008099 D-loop; other site 592316008100 H-loop/switch region; other site 592316008101 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316008102 MATE family multidrug exporter; Provisional; Region: PRK10189 592316008103 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 592316008104 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 592316008105 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 592316008106 Walker A/P-loop; other site 592316008107 ATP binding site [chemical binding]; other site 592316008108 Q-loop/lid; other site 592316008109 ABC transporter signature motif; other site 592316008110 Walker B; other site 592316008111 D-loop; other site 592316008112 H-loop/switch region; other site 592316008113 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 592316008114 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 592316008115 Walker A/P-loop; other site 592316008116 ATP binding site [chemical binding]; other site 592316008117 Q-loop/lid; other site 592316008118 ABC transporter signature motif; other site 592316008119 Walker B; other site 592316008120 D-loop; other site 592316008121 H-loop/switch region; other site 592316008122 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 592316008123 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 592316008124 TM-ABC transporter signature motif; other site 592316008125 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316008126 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 592316008127 TM-ABC transporter signature motif; other site 592316008128 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 592316008129 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 592316008130 dimerization interface [polypeptide binding]; other site 592316008131 ligand binding site [chemical binding]; other site 592316008132 AMP nucleosidase; Provisional; Region: PRK08292 592316008133 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 592316008134 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 592316008135 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 592316008136 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592316008137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316008138 active site 592316008139 phosphorylation site [posttranslational modification] 592316008140 intermolecular recognition site; other site 592316008141 dimerization interface [polypeptide binding]; other site 592316008142 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592316008143 DNA binding site [nucleotide binding] 592316008144 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 592316008145 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592316008146 substrate binding site [chemical binding]; other site 592316008147 ATP binding site [chemical binding]; other site 592316008148 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 592316008149 intersubunit interface [polypeptide binding]; other site 592316008150 active site 592316008151 zinc binding site [ion binding]; other site 592316008152 Na+ binding site [ion binding]; other site 592316008153 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 592316008154 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 592316008155 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 592316008156 putative ligand binding site [chemical binding]; other site 592316008157 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316008158 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592316008159 TM-ABC transporter signature motif; other site 592316008160 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 592316008161 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 592316008162 Walker A/P-loop; other site 592316008163 ATP binding site [chemical binding]; other site 592316008164 Q-loop/lid; other site 592316008165 ABC transporter signature motif; other site 592316008166 Walker B; other site 592316008167 D-loop; other site 592316008168 H-loop/switch region; other site 592316008169 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 592316008170 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 592316008171 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592316008172 dimerization interface [polypeptide binding]; other site 592316008173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592316008174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316008175 ATP binding site [chemical binding]; other site 592316008176 Mg2+ binding site [ion binding]; other site 592316008177 G-X-G motif; other site 592316008178 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 592316008179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316008180 active site 592316008181 phosphorylation site [posttranslational modification] 592316008182 intermolecular recognition site; other site 592316008183 dimerization interface [polypeptide binding]; other site 592316008184 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 592316008185 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 592316008186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316008187 dimer interface [polypeptide binding]; other site 592316008188 conserved gate region; other site 592316008189 putative PBP binding loops; other site 592316008190 ABC-ATPase subunit interface; other site 592316008191 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 592316008192 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 592316008193 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 592316008194 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 592316008195 Walker A/P-loop; other site 592316008196 ATP binding site [chemical binding]; other site 592316008197 Q-loop/lid; other site 592316008198 ABC transporter signature motif; other site 592316008199 Walker B; other site 592316008200 D-loop; other site 592316008201 H-loop/switch region; other site 592316008202 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 592316008203 active site 592316008204 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 592316008205 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 592316008206 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 592316008207 active site 592316008208 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 592316008209 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 592316008210 Walker A/P-loop; other site 592316008211 ATP binding site [chemical binding]; other site 592316008212 Q-loop/lid; other site 592316008213 ABC transporter signature motif; other site 592316008214 Walker B; other site 592316008215 D-loop; other site 592316008216 H-loop/switch region; other site 592316008217 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 592316008218 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316008219 Walker A/P-loop; other site 592316008220 ATP binding site [chemical binding]; other site 592316008221 Q-loop/lid; other site 592316008222 ABC transporter signature motif; other site 592316008223 Walker B; other site 592316008224 D-loop; other site 592316008225 H-loop/switch region; other site 592316008226 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316008227 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 592316008228 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 592316008229 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 592316008230 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 592316008231 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 592316008232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316008233 DNA-binding site [nucleotide binding]; DNA binding site 592316008234 UTRA domain; Region: UTRA; pfam07702 592316008235 CHASE4 domain; Region: CHASE4; cl01308 592316008236 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592316008237 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316008238 metal binding site [ion binding]; metal-binding site 592316008239 active site 592316008240 I-site; other site 592316008241 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592316008242 short chain dehydrogenase; Provisional; Region: PRK06180 592316008243 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 592316008244 NADP binding site [chemical binding]; other site 592316008245 active site 592316008246 steroid binding site; other site 592316008247 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 592316008248 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 592316008249 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 592316008250 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 592316008251 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 592316008252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316008253 Coenzyme A binding pocket [chemical binding]; other site 592316008254 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 592316008255 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592316008256 putative DNA binding site [nucleotide binding]; other site 592316008257 putative Zn2+ binding site [ion binding]; other site 592316008258 AsnC family; Region: AsnC_trans_reg; pfam01037 592316008259 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 592316008260 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592316008261 inhibitor-cofactor binding pocket; inhibition site 592316008262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316008263 catalytic residue [active] 592316008264 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 592316008265 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 592316008266 metal binding site [ion binding]; metal-binding site 592316008267 putative dimer interface [polypeptide binding]; other site 592316008268 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 592316008269 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 592316008270 putative ligand binding site [chemical binding]; other site 592316008271 NAD binding site [chemical binding]; other site 592316008272 dimerization interface [polypeptide binding]; other site 592316008273 catalytic site [active] 592316008274 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316008275 Coenzyme A binding pocket [chemical binding]; other site 592316008276 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 592316008277 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 592316008278 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316008279 Walker A/P-loop; other site 592316008280 ATP binding site [chemical binding]; other site 592316008281 Q-loop/lid; other site 592316008282 ABC transporter signature motif; other site 592316008283 Walker B; other site 592316008284 D-loop; other site 592316008285 H-loop/switch region; other site 592316008286 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316008287 Walker A/P-loop; other site 592316008288 ATP binding site [chemical binding]; other site 592316008289 Q-loop/lid; other site 592316008290 ABC transporter signature motif; other site 592316008291 Walker B; other site 592316008292 D-loop; other site 592316008293 H-loop/switch region; other site 592316008294 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 592316008295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316008296 dimer interface [polypeptide binding]; other site 592316008297 conserved gate region; other site 592316008298 ABC-ATPase subunit interface; other site 592316008299 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316008300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316008301 dimer interface [polypeptide binding]; other site 592316008302 conserved gate region; other site 592316008303 putative PBP binding loops; other site 592316008304 ABC-ATPase subunit interface; other site 592316008305 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592316008306 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 592316008307 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 592316008308 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 592316008309 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 592316008310 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 592316008311 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 592316008312 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 592316008313 NAD(P) binding site [chemical binding]; other site 592316008314 catalytic residues [active] 592316008315 succinic semialdehyde dehydrogenase; Region: PLN02278 592316008316 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 592316008317 tetramerization interface [polypeptide binding]; other site 592316008318 NAD(P) binding site [chemical binding]; other site 592316008319 catalytic residues [active] 592316008320 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 592316008321 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316008322 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 592316008323 substrate binding site [chemical binding]; other site 592316008324 dimerization interface [polypeptide binding]; other site 592316008325 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 592316008326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316008327 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 592316008328 putative dimerization interface [polypeptide binding]; other site 592316008329 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592316008330 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316008331 TM-ABC transporter signature motif; other site 592316008332 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 592316008333 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 592316008334 Walker A/P-loop; other site 592316008335 ATP binding site [chemical binding]; other site 592316008336 Q-loop/lid; other site 592316008337 ABC transporter signature motif; other site 592316008338 Walker B; other site 592316008339 D-loop; other site 592316008340 H-loop/switch region; other site 592316008341 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 592316008342 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 592316008343 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 592316008344 putative ligand binding site [chemical binding]; other site 592316008345 PGAP1-like protein; Region: PGAP1; pfam07819 592316008346 Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776 592316008347 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316008348 non-specific DNA binding site [nucleotide binding]; other site 592316008349 salt bridge; other site 592316008350 sequence-specific DNA binding site [nucleotide binding]; other site 592316008351 PAAR motif; Region: PAAR_motif; pfam05488 592316008352 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 592316008353 RHS Repeat; Region: RHS_repeat; pfam05593 592316008354 RHS Repeat; Region: RHS_repeat; pfam05593 592316008355 RHS Repeat; Region: RHS_repeat; pfam05593 592316008356 RHS Repeat; Region: RHS_repeat; pfam05593 592316008357 RHS protein; Region: RHS; pfam03527 592316008358 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 592316008359 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 592316008360 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 592316008361 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 592316008362 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 592316008363 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 592316008364 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 592316008365 Catalytic domain of Protein Kinases; Region: PKc; cd00180 592316008366 active site 592316008367 ATP binding site [chemical binding]; other site 592316008368 substrate binding site [chemical binding]; other site 592316008369 activation loop (A-loop); other site 592316008370 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 592316008371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316008372 Walker A motif; other site 592316008373 ATP binding site [chemical binding]; other site 592316008374 Walker B motif; other site 592316008375 arginine finger; other site 592316008376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316008377 Walker A motif; other site 592316008378 ATP binding site [chemical binding]; other site 592316008379 Walker B motif; other site 592316008380 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 592316008381 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 592316008382 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 592316008383 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 592316008384 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 592316008385 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 592316008386 ImpE protein; Region: ImpE; pfam07024 592316008387 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 592316008388 active site 592316008389 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 592316008390 phosphopeptide binding site; other site 592316008391 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 592316008392 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 592316008393 Protein of unknown function (DUF796); Region: DUF796; pfam05638 592316008394 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 592316008395 Protein of unknown function (DUF877); Region: DUF877; pfam05943 592316008396 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 592316008397 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 592316008398 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 592316008399 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 592316008400 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 592316008401 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 592316008402 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 592316008403 hypothetical protein; Provisional; Region: PRK07033 592316008404 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 592316008405 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592316008406 ligand binding site [chemical binding]; other site 592316008407 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 592316008408 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 592316008409 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 592316008410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316008411 dimer interface [polypeptide binding]; other site 592316008412 conserved gate region; other site 592316008413 ABC-ATPase subunit interface; other site 592316008414 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 592316008415 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 592316008416 Walker A/P-loop; other site 592316008417 ATP binding site [chemical binding]; other site 592316008418 Q-loop/lid; other site 592316008419 ABC transporter signature motif; other site 592316008420 Walker B; other site 592316008421 D-loop; other site 592316008422 H-loop/switch region; other site 592316008423 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 592316008424 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 592316008425 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316008426 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 592316008427 FAD binding domain; Region: FAD_binding_4; pfam01565 592316008428 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 592316008429 Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537 592316008430 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 592316008431 substrate binding site; other site 592316008432 Manganese binding site; other site 592316008433 dimer interface; other site 592316008434 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592316008435 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592316008436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 592316008437 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 592316008438 maleylacetoacetate isomerase; Region: maiA; TIGR01262 592316008439 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 592316008440 dimer interface [polypeptide binding]; other site 592316008441 N-terminal domain interface [polypeptide binding]; other site 592316008442 putative substrate binding pocket (H-site) [chemical binding]; other site 592316008443 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 592316008444 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 592316008445 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 592316008446 Fatty acid desaturase; Region: FA_desaturase; pfam00487 592316008447 putative di-iron ligands [ion binding]; other site 592316008448 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 592316008449 membrane-bound complex binding site; other site 592316008450 hinge residues; other site 592316008451 elongation factor G; Reviewed; Region: PRK00007 592316008452 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 592316008453 G1 box; other site 592316008454 putative GEF interaction site [polypeptide binding]; other site 592316008455 GTP/Mg2+ binding site [chemical binding]; other site 592316008456 Switch I region; other site 592316008457 G2 box; other site 592316008458 G3 box; other site 592316008459 Switch II region; other site 592316008460 G4 box; other site 592316008461 G5 box; other site 592316008462 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 592316008463 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 592316008464 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 592316008465 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 592316008466 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 592316008467 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 592316008468 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316008469 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316008470 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 592316008471 putative effector binding pocket; other site 592316008472 dimerization interface [polypeptide binding]; other site 592316008473 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 592316008474 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 592316008475 tetramerization interface [polypeptide binding]; other site 592316008476 NAD(P) binding site [chemical binding]; other site 592316008477 catalytic residues [active] 592316008478 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 592316008479 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 592316008480 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 592316008481 NAD(P) binding site [chemical binding]; other site 592316008482 Uncharacterized conserved protein [Function unknown]; Region: COG1434 592316008483 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 592316008484 putative active site [active] 592316008485 lac repressor; Reviewed; Region: lacI; PRK09526 592316008486 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316008487 DNA binding site [nucleotide binding] 592316008488 domain linker motif; other site 592316008489 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 592316008490 ligand binding site [chemical binding]; other site 592316008491 dimerization interface (open form) [polypeptide binding]; other site 592316008492 dimerization interface (closed form) [polypeptide binding]; other site 592316008493 hypothetical protein; Provisional; Region: PRK05423 592316008494 Predicted membrane protein [Function unknown]; Region: COG1289 592316008495 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 592316008496 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 592316008497 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 592316008498 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 592316008499 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 592316008500 exonuclease I; Provisional; Region: sbcB; PRK11779 592316008501 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 592316008502 active site 592316008503 catalytic site [active] 592316008504 substrate binding site [chemical binding]; other site 592316008505 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 592316008506 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 592316008507 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 592316008508 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 592316008509 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 592316008510 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 592316008511 catalytic triad [active] 592316008512 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 592316008513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316008514 non-specific DNA binding site [nucleotide binding]; other site 592316008515 salt bridge; other site 592316008516 sequence-specific DNA binding site [nucleotide binding]; other site 592316008517 Cupin domain; Region: Cupin_2; pfam07883 592316008518 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 592316008519 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 592316008520 Predicted membrane protein [Function unknown]; Region: COG2246 592316008521 GtrA-like protein; Region: GtrA; pfam04138 592316008522 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 592316008523 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 592316008524 Ligand binding site; other site 592316008525 Putative Catalytic site; other site 592316008526 DXD motif; other site 592316008527 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 592316008528 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 592316008529 putative NAD(P) binding site [chemical binding]; other site 592316008530 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 592316008531 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 592316008532 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 592316008533 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 592316008534 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 592316008535 NAD binding site [chemical binding]; other site 592316008536 dimerization interface [polypeptide binding]; other site 592316008537 product binding site; other site 592316008538 substrate binding site [chemical binding]; other site 592316008539 zinc binding site [ion binding]; other site 592316008540 catalytic residues [active] 592316008541 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 592316008542 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316008543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316008544 homodimer interface [polypeptide binding]; other site 592316008545 catalytic residue [active] 592316008546 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 592316008547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316008548 active site 592316008549 motif I; other site 592316008550 motif II; other site 592316008551 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 592316008552 putative active site pocket [active] 592316008553 4-fold oligomerization interface [polypeptide binding]; other site 592316008554 metal binding residues [ion binding]; metal-binding site 592316008555 3-fold/trimer interface [polypeptide binding]; other site 592316008556 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 592316008557 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 592316008558 putative active site [active] 592316008559 oxyanion strand; other site 592316008560 catalytic triad [active] 592316008561 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 592316008562 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 592316008563 catalytic residues [active] 592316008564 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 592316008565 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 592316008566 substrate binding site [chemical binding]; other site 592316008567 glutamase interaction surface [polypeptide binding]; other site 592316008568 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 592316008569 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 592316008570 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 592316008571 metal binding site [ion binding]; metal-binding site 592316008572 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 592316008573 putative deacylase active site [active] 592316008574 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 592316008575 O-Antigen ligase; Region: Wzy_C; pfam04932 592316008576 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 592316008577 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 592316008578 putative ADP-binding pocket [chemical binding]; other site 592316008579 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 592316008580 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316008581 substrate binding pocket [chemical binding]; other site 592316008582 membrane-bound complex binding site; other site 592316008583 hinge residues; other site 592316008584 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 592316008585 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 592316008586 active site 592316008587 Zn binding site [ion binding]; other site 592316008588 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 592316008589 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 592316008590 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 592316008591 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 592316008592 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 592316008593 Walker A/P-loop; other site 592316008594 ATP binding site [chemical binding]; other site 592316008595 Q-loop/lid; other site 592316008596 ABC transporter signature motif; other site 592316008597 Walker B; other site 592316008598 D-loop; other site 592316008599 H-loop/switch region; other site 592316008600 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 592316008601 ABC-2 type transporter; Region: ABC2_membrane; cl17235 592316008602 Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754 592316008603 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 592316008604 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 592316008605 Probable Catalytic site; other site 592316008606 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 592316008607 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 592316008608 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 592316008609 substrate binding site; other site 592316008610 tetramer interface; other site 592316008611 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 592316008612 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 592316008613 NADP binding site [chemical binding]; other site 592316008614 active site 592316008615 putative substrate binding site [chemical binding]; other site 592316008616 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 592316008617 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 592316008618 NAD binding site [chemical binding]; other site 592316008619 substrate binding site [chemical binding]; other site 592316008620 homodimer interface [polypeptide binding]; other site 592316008621 active site 592316008622 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 592316008623 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 592316008624 NAD binding site [chemical binding]; other site 592316008625 homodimer interface [polypeptide binding]; other site 592316008626 active site 592316008627 substrate binding site [chemical binding]; other site 592316008628 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 592316008629 active site 592316008630 tetramer interface; other site 592316008631 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 592316008632 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 592316008633 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 592316008634 putative ADP-binding pocket [chemical binding]; other site 592316008635 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 592316008636 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 592316008637 Head binding; Region: Head_binding; pfam09008 592316008638 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592316008639 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 592316008640 putative ADP-binding pocket [chemical binding]; other site 592316008641 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 592316008642 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592316008643 active site 592316008644 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 592316008645 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592316008646 active site 592316008647 tyrosine kinase; Provisional; Region: PRK11519 592316008648 Chain length determinant protein; Region: Wzz; pfam02706 592316008649 Chain length determinant protein; Region: Wzz; cl15801 592316008650 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 592316008651 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 592316008652 Low molecular weight phosphatase family; Region: LMWPc; cd00115 592316008653 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 592316008654 active site 592316008655 polysaccharide export protein Wza; Provisional; Region: PRK15078 592316008656 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 592316008657 SLBB domain; Region: SLBB; pfam10531 592316008658 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 592316008659 Bacterial sugar transferase; Region: Bac_transf; pfam02397 592316008660 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 592316008661 gliding motility-associated protein GldE; Region: GldE; TIGR03520 592316008662 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 592316008663 Transporter associated domain; Region: CorC_HlyC; smart01091 592316008664 putative assembly protein; Provisional; Region: PRK10833 592316008665 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 592316008666 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 592316008667 trimer interface [polypeptide binding]; other site 592316008668 active site 592316008669 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 592316008670 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 592316008671 ATP-binding site [chemical binding]; other site 592316008672 Sugar specificity; other site 592316008673 Pyrimidine base specificity; other site 592316008674 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 592316008675 active site 592316008676 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 592316008677 MASE1; Region: MASE1; cl17823 592316008678 PAS domain S-box; Region: sensory_box; TIGR00229 592316008679 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592316008680 putative active site [active] 592316008681 heme pocket [chemical binding]; other site 592316008682 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 592316008683 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592316008684 putative active site [active] 592316008685 heme pocket [chemical binding]; other site 592316008686 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592316008687 putative active site [active] 592316008688 heme pocket [chemical binding]; other site 592316008689 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592316008690 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316008691 metal binding site [ion binding]; metal-binding site 592316008692 active site 592316008693 I-site; other site 592316008694 putative chaperone; Provisional; Region: PRK11678 592316008695 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 592316008696 nucleotide binding site [chemical binding]; other site 592316008697 putative NEF/HSP70 interaction site [polypeptide binding]; other site 592316008698 SBD interface [polypeptide binding]; other site 592316008699 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 592316008700 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592316008701 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592316008702 active site 592316008703 catalytic tetrad [active] 592316008704 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 592316008705 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592316008706 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316008707 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 592316008708 Protein export membrane protein; Region: SecD_SecF; cl14618 592316008709 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 592316008710 putative transporter; Provisional; Region: PRK10504 592316008711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316008712 putative substrate translocation pore; other site 592316008713 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 592316008714 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592316008715 dimerization interface [polypeptide binding]; other site 592316008716 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316008717 dimer interface [polypeptide binding]; other site 592316008718 phosphorylation site [posttranslational modification] 592316008719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316008720 ATP binding site [chemical binding]; other site 592316008721 Mg2+ binding site [ion binding]; other site 592316008722 G-X-G motif; other site 592316008723 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 592316008724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316008725 active site 592316008726 phosphorylation site [posttranslational modification] 592316008727 intermolecular recognition site; other site 592316008728 dimerization interface [polypeptide binding]; other site 592316008729 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592316008730 DNA binding site [nucleotide binding] 592316008731 putative protease; Provisional; Region: PRK15452 592316008732 Peptidase family U32; Region: Peptidase_U32; pfam01136 592316008733 lipid kinase; Reviewed; Region: PRK13054 592316008734 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 592316008735 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 592316008736 putative oxidoreductase; Provisional; Region: PRK10083 592316008737 putative NAD(P) binding site [chemical binding]; other site 592316008738 catalytic Zn binding site [ion binding]; other site 592316008739 structural Zn binding site [ion binding]; other site 592316008740 D-galactonate transporter; Region: 2A0114; TIGR00893 592316008741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316008742 putative substrate translocation pore; other site 592316008743 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 592316008744 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 592316008745 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 592316008746 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316008747 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 592316008748 DNA-binding site [nucleotide binding]; DNA binding site 592316008749 FCD domain; Region: FCD; pfam07729 592316008750 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 592316008751 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 592316008752 putative active site; other site 592316008753 catalytic residue [active] 592316008754 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 592316008755 dimer interface [polypeptide binding]; other site 592316008756 substrate binding site [chemical binding]; other site 592316008757 ATP binding site [chemical binding]; other site 592316008758 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 592316008759 substrate binding site [chemical binding]; other site 592316008760 multimerization interface [polypeptide binding]; other site 592316008761 ATP binding site [chemical binding]; other site 592316008762 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 592316008763 outer membrane porin, OprD family; Region: OprD; pfam03573 592316008764 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 592316008765 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 592316008766 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 592316008767 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 592316008768 active site 592316008769 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 592316008770 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 592316008771 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 592316008772 catalytic residue [active] 592316008773 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 592316008774 catalytic residues [active] 592316008775 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592316008776 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592316008777 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 592316008778 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 592316008779 dimer interface [polypeptide binding]; other site 592316008780 decamer (pentamer of dimers) interface [polypeptide binding]; other site 592316008781 catalytic triad [active] 592316008782 peroxidatic and resolving cysteines [active] 592316008783 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 592316008784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316008785 Coenzyme A binding pocket [chemical binding]; other site 592316008786 antiporter inner membrane protein; Provisional; Region: PRK11670 592316008787 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 592316008788 Walker A motif; other site 592316008789 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 592316008790 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 592316008791 active site 592316008792 HIGH motif; other site 592316008793 KMSKS motif; other site 592316008794 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 592316008795 tRNA binding surface [nucleotide binding]; other site 592316008796 anticodon binding site; other site 592316008797 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 592316008798 dimer interface [polypeptide binding]; other site 592316008799 putative tRNA-binding site [nucleotide binding]; other site 592316008800 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 592316008801 putative active site [active] 592316008802 LrgA family; Region: LrgA; cl00608 592316008803 hypothetical protein; Provisional; Region: PRK10711 592316008804 cytidine deaminase; Provisional; Region: PRK09027 592316008805 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 592316008806 active site 592316008807 catalytic motif [active] 592316008808 Zn binding site [ion binding]; other site 592316008809 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 592316008810 active site 592316008811 catalytic motif [active] 592316008812 Zn binding site [ion binding]; other site 592316008813 malate dehydrogenase; Provisional; Region: PRK13529 592316008814 Malic enzyme, N-terminal domain; Region: malic; pfam00390 592316008815 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 592316008816 NAD(P) binding site [chemical binding]; other site 592316008817 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 592316008818 putative active site [active] 592316008819 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316008820 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592316008821 TM-ABC transporter signature motif; other site 592316008822 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 592316008823 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 592316008824 Walker A/P-loop; other site 592316008825 ATP binding site [chemical binding]; other site 592316008826 Q-loop/lid; other site 592316008827 ABC transporter signature motif; other site 592316008828 Walker B; other site 592316008829 D-loop; other site 592316008830 H-loop/switch region; other site 592316008831 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 592316008832 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 592316008833 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 592316008834 ligand binding site [chemical binding]; other site 592316008835 calcium binding site [ion binding]; other site 592316008836 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 592316008837 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316008838 DNA binding site [nucleotide binding] 592316008839 domain linker motif; other site 592316008840 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 592316008841 dimerization interface (closed form) [polypeptide binding]; other site 592316008842 ligand binding site [chemical binding]; other site 592316008843 Predicted membrane protein [Function unknown]; Region: COG2311 592316008844 hypothetical protein; Provisional; Region: PRK10835 592316008845 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 592316008846 GTP cyclohydrolase I; Provisional; Region: PLN03044 592316008847 active site 592316008848 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 592316008849 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316008850 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316008851 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 592316008852 putative dimerization interface [polypeptide binding]; other site 592316008853 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 592316008854 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 592316008855 substrate binding site [chemical binding]; other site 592316008856 catalytic Zn binding site [ion binding]; other site 592316008857 NAD binding site [chemical binding]; other site 592316008858 structural Zn binding site [ion binding]; other site 592316008859 dimer interface [polypeptide binding]; other site 592316008860 S-formylglutathione hydrolase; Region: PLN02442 592316008861 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 592316008862 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 592316008863 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 592316008864 Walker A/P-loop; other site 592316008865 ATP binding site [chemical binding]; other site 592316008866 Q-loop/lid; other site 592316008867 ABC transporter signature motif; other site 592316008868 Walker B; other site 592316008869 D-loop; other site 592316008870 H-loop/switch region; other site 592316008871 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 592316008872 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592316008873 ABC-ATPase subunit interface; other site 592316008874 dimer interface [polypeptide binding]; other site 592316008875 putative PBP binding regions; other site 592316008876 lysine transporter; Provisional; Region: PRK10836 592316008877 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 592316008878 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316008879 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 592316008880 putative dimerization interface [polypeptide binding]; other site 592316008881 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 592316008882 endonuclease IV; Provisional; Region: PRK01060 592316008883 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 592316008884 AP (apurinic/apyrimidinic) site pocket; other site 592316008885 DNA interaction; other site 592316008886 Metal-binding active site; metal-binding site 592316008887 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 592316008888 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 592316008889 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 592316008890 active site 592316008891 P-loop; other site 592316008892 phosphorylation site [posttranslational modification] 592316008893 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 592316008894 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 592316008895 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 592316008896 putative substrate binding site [chemical binding]; other site 592316008897 putative ATP binding site [chemical binding]; other site 592316008898 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 592316008899 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 592316008900 active site 592316008901 phosphorylation site [posttranslational modification] 592316008902 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 592316008903 dimerization domain swap beta strand [polypeptide binding]; other site 592316008904 regulatory protein interface [polypeptide binding]; other site 592316008905 active site 592316008906 regulatory phosphorylation site [posttranslational modification]; other site 592316008907 Flagellin N-methylase; Region: FliB; cl00497 592316008908 elongation factor P; Provisional; Region: PRK04542 592316008909 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 592316008910 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 592316008911 RNA binding site [nucleotide binding]; other site 592316008912 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 592316008913 RNA binding site [nucleotide binding]; other site 592316008914 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 592316008915 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 592316008916 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 592316008917 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 592316008918 NlpC/P60 family; Region: NLPC_P60; pfam00877 592316008919 phage resistance protein; Provisional; Region: PRK10551 592316008920 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 592316008921 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592316008922 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 592316008923 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 592316008924 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 592316008925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316008926 dimer interface [polypeptide binding]; other site 592316008927 conserved gate region; other site 592316008928 putative PBP binding loops; other site 592316008929 ABC-ATPase subunit interface; other site 592316008930 microcin C ABC transporter permease; Provisional; Region: PRK15021 592316008931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316008932 dimer interface [polypeptide binding]; other site 592316008933 conserved gate region; other site 592316008934 putative PBP binding loops; other site 592316008935 ABC-ATPase subunit interface; other site 592316008936 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 592316008937 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316008938 Walker A/P-loop; other site 592316008939 ATP binding site [chemical binding]; other site 592316008940 Q-loop/lid; other site 592316008941 ABC transporter signature motif; other site 592316008942 Walker B; other site 592316008943 D-loop; other site 592316008944 H-loop/switch region; other site 592316008945 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316008946 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316008947 Walker A/P-loop; other site 592316008948 ATP binding site [chemical binding]; other site 592316008949 Q-loop/lid; other site 592316008950 ABC transporter signature motif; other site 592316008951 Walker B; other site 592316008952 D-loop; other site 592316008953 H-loop/switch region; other site 592316008954 YejG-like protein; Region: YejG; pfam13989 592316008955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316008956 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 592316008957 putative substrate translocation pore; other site 592316008958 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 592316008959 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592316008960 RNA binding surface [nucleotide binding]; other site 592316008961 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 592316008962 active site 592316008963 uracil binding [chemical binding]; other site 592316008964 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 592316008965 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592316008966 ATP binding site [chemical binding]; other site 592316008967 putative Mg++ binding site [ion binding]; other site 592316008968 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592316008969 nucleotide binding region [chemical binding]; other site 592316008970 ATP-binding site [chemical binding]; other site 592316008971 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 592316008972 5S rRNA interface [nucleotide binding]; other site 592316008973 CTC domain interface [polypeptide binding]; other site 592316008974 L16 interface [polypeptide binding]; other site 592316008975 Nucleoid-associated protein [General function prediction only]; Region: COG3081 592316008976 nucleoid-associated protein NdpA; Validated; Region: PRK00378 592316008977 hypothetical protein; Provisional; Region: PRK13689 592316008978 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 592316008979 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 592316008980 Sulfatase; Region: Sulfatase; cl17466 592316008981 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 592316008982 ArsC family; Region: ArsC; pfam03960 592316008983 catalytic residues [active] 592316008984 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592316008985 dimerization interface [polypeptide binding]; other site 592316008986 putative DNA binding site [nucleotide binding]; other site 592316008987 putative Zn2+ binding site [ion binding]; other site 592316008988 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 592316008989 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592316008990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 592316008991 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 592316008992 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 592316008993 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 592316008994 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 592316008995 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592316008996 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316008997 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 592316008998 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316008999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316009000 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 592316009001 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316009002 N-terminal plug; other site 592316009003 ligand-binding site [chemical binding]; other site 592316009004 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 592316009005 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 592316009006 intersubunit interface [polypeptide binding]; other site 592316009007 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 592316009008 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592316009009 ABC-ATPase subunit interface; other site 592316009010 dimer interface [polypeptide binding]; other site 592316009011 putative PBP binding regions; other site 592316009012 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592316009013 ABC-ATPase subunit interface; other site 592316009014 dimer interface [polypeptide binding]; other site 592316009015 putative PBP binding regions; other site 592316009016 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592316009017 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592316009018 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 592316009019 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 592316009020 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 592316009021 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 592316009022 Walker A/P-loop; other site 592316009023 ATP binding site [chemical binding]; other site 592316009024 Q-loop/lid; other site 592316009025 ABC transporter signature motif; other site 592316009026 Walker B; other site 592316009027 D-loop; other site 592316009028 H-loop/switch region; other site 592316009029 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 592316009030 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 592316009031 ApbE family; Region: ApbE; pfam02424 592316009032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 592316009033 SnoaL-like domain; Region: SnoaL_2; pfam12680 592316009034 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592316009035 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316009036 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 592316009037 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 592316009038 trimer interface [polypeptide binding]; other site 592316009039 eyelet of channel; other site 592316009040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316009041 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592316009042 putative substrate translocation pore; other site 592316009043 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 592316009044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316009045 ATP binding site [chemical binding]; other site 592316009046 Mg2+ binding site [ion binding]; other site 592316009047 G-X-G motif; other site 592316009048 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 592316009049 putative binding surface; other site 592316009050 active site 592316009051 transcriptional regulator RcsB; Provisional; Region: PRK10840 592316009052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316009053 active site 592316009054 phosphorylation site [posttranslational modification] 592316009055 intermolecular recognition site; other site 592316009056 dimerization interface [polypeptide binding]; other site 592316009057 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592316009058 DNA binding residues [nucleotide binding] 592316009059 dimerization interface [polypeptide binding]; other site 592316009060 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 592316009061 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316009062 dimer interface [polypeptide binding]; other site 592316009063 phosphorylation site [posttranslational modification] 592316009064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316009065 ATP binding site [chemical binding]; other site 592316009066 Mg2+ binding site [ion binding]; other site 592316009067 G-X-G motif; other site 592316009068 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 592316009069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316009070 active site 592316009071 phosphorylation site [posttranslational modification] 592316009072 intermolecular recognition site; other site 592316009073 dimerization interface [polypeptide binding]; other site 592316009074 DNA gyrase subunit A; Validated; Region: PRK05560 592316009075 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 592316009076 CAP-like domain; other site 592316009077 active site 592316009078 primary dimer interface [polypeptide binding]; other site 592316009079 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592316009080 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592316009081 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592316009082 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592316009083 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592316009084 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592316009085 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 592316009086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316009087 S-adenosylmethionine binding site [chemical binding]; other site 592316009088 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 592316009089 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 592316009090 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 592316009091 ligand binding site [chemical binding]; other site 592316009092 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316009093 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592316009094 TM-ABC transporter signature motif; other site 592316009095 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592316009096 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316009097 TM-ABC transporter signature motif; other site 592316009098 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 592316009099 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 592316009100 Walker A/P-loop; other site 592316009101 ATP binding site [chemical binding]; other site 592316009102 Q-loop/lid; other site 592316009103 ABC transporter signature motif; other site 592316009104 Walker B; other site 592316009105 D-loop; other site 592316009106 H-loop/switch region; other site 592316009107 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 592316009108 transcriptional regulator LsrR; Provisional; Region: PRK15418 592316009109 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 592316009110 non-specific DNA interactions [nucleotide binding]; other site 592316009111 DNA binding site [nucleotide binding] 592316009112 sequence specific DNA binding site [nucleotide binding]; other site 592316009113 putative cAMP binding site [chemical binding]; other site 592316009114 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 592316009115 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 592316009116 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 592316009117 putative N- and C-terminal domain interface [polypeptide binding]; other site 592316009118 putative active site [active] 592316009119 putative MgATP binding site [chemical binding]; other site 592316009120 catalytic site [active] 592316009121 metal binding site [ion binding]; metal-binding site 592316009122 putative carbohydrate binding site [chemical binding]; other site 592316009123 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 592316009124 ATP cone domain; Region: ATP-cone; pfam03477 592316009125 Class I ribonucleotide reductase; Region: RNR_I; cd01679 592316009126 active site 592316009127 dimer interface [polypeptide binding]; other site 592316009128 catalytic residues [active] 592316009129 effector binding site; other site 592316009130 R2 peptide binding site; other site 592316009131 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 592316009132 dimer interface [polypeptide binding]; other site 592316009133 putative radical transfer pathway; other site 592316009134 diiron center [ion binding]; other site 592316009135 tyrosyl radical; other site 592316009136 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 592316009137 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 592316009138 catalytic loop [active] 592316009139 iron binding site [ion binding]; other site 592316009140 hypothetical protein; Provisional; Region: PRK03673 592316009141 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 592316009142 putative MPT binding site; other site 592316009143 Competence-damaged protein; Region: CinA; cl00666 592316009144 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 592316009145 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 592316009146 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 592316009147 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592316009148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316009149 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592316009150 putative substrate translocation pore; other site 592316009151 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 592316009152 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 592316009153 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 592316009154 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 592316009155 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 592316009156 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 592316009157 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 592316009158 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 592316009159 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 592316009160 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 592316009161 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 592316009162 4Fe-4S binding domain; Region: Fer4; pfam00037 592316009163 4Fe-4S binding domain; Region: Fer4; pfam00037 592316009164 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 592316009165 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 592316009166 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 592316009167 catalytic loop [active] 592316009168 iron binding site [ion binding]; other site 592316009169 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 592316009170 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 592316009171 [4Fe-4S] binding site [ion binding]; other site 592316009172 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 592316009173 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 592316009174 SLBB domain; Region: SLBB; pfam10531 592316009175 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 592316009176 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 592316009177 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 592316009178 putative dimer interface [polypeptide binding]; other site 592316009179 [2Fe-2S] cluster binding site [ion binding]; other site 592316009180 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 592316009181 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 592316009182 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 592316009183 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 592316009184 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 592316009185 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 592316009186 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316009187 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 592316009188 putative dimerization interface [polypeptide binding]; other site 592316009189 aminotransferase AlaT; Validated; Region: PRK09265 592316009190 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316009191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316009192 homodimer interface [polypeptide binding]; other site 592316009193 catalytic residue [active] 592316009194 5'-nucleotidase; Provisional; Region: PRK03826 592316009195 putative phosphatase; Provisional; Region: PRK11587 592316009196 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316009197 motif II; other site 592316009198 hypothetical protein; Validated; Region: PRK05445 592316009199 hypothetical protein; Provisional; Region: PRK01816 592316009200 propionate/acetate kinase; Provisional; Region: PRK12379 592316009201 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 592316009202 phosphate acetyltransferase; Reviewed; Region: PRK05632 592316009203 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 592316009204 DRTGG domain; Region: DRTGG; pfam07085 592316009205 phosphate acetyltransferase; Region: pta; TIGR00651 592316009206 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 592316009207 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 592316009208 Walker A/P-loop; other site 592316009209 ATP binding site [chemical binding]; other site 592316009210 Q-loop/lid; other site 592316009211 ABC transporter signature motif; other site 592316009212 Walker B; other site 592316009213 D-loop; other site 592316009214 H-loop/switch region; other site 592316009215 TOBE domain; Region: TOBE_2; pfam08402 592316009216 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 592316009217 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316009218 DNA-binding site [nucleotide binding]; DNA binding site 592316009219 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316009220 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316009221 homodimer interface [polypeptide binding]; other site 592316009222 catalytic residue [active] 592316009223 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 592316009224 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592316009225 inhibitor-cofactor binding pocket; inhibition site 592316009226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316009227 catalytic residue [active] 592316009228 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 592316009229 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 592316009230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316009231 dimer interface [polypeptide binding]; other site 592316009232 conserved gate region; other site 592316009233 putative PBP binding loops; other site 592316009234 ABC-ATPase subunit interface; other site 592316009235 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 592316009236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316009237 dimer interface [polypeptide binding]; other site 592316009238 conserved gate region; other site 592316009239 putative PBP binding loops; other site 592316009240 ABC-ATPase subunit interface; other site 592316009241 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 592316009242 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 592316009243 nudix motif; other site 592316009244 glutathione S-transferase; Provisional; Region: PRK15113 592316009245 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 592316009246 C-terminal domain interface [polypeptide binding]; other site 592316009247 GSH binding site (G-site) [chemical binding]; other site 592316009248 dimer interface [polypeptide binding]; other site 592316009249 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 592316009250 N-terminal domain interface [polypeptide binding]; other site 592316009251 putative dimer interface [polypeptide binding]; other site 592316009252 putative substrate binding pocket (H-site) [chemical binding]; other site 592316009253 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 592316009254 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 592316009255 putative NAD(P) binding site [chemical binding]; other site 592316009256 putative active site [active] 592316009257 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 592316009258 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316009259 Walker A/P-loop; other site 592316009260 ATP binding site [chemical binding]; other site 592316009261 Q-loop/lid; other site 592316009262 ABC transporter signature motif; other site 592316009263 Walker B; other site 592316009264 D-loop; other site 592316009265 H-loop/switch region; other site 592316009266 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316009267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316009268 dimer interface [polypeptide binding]; other site 592316009269 conserved gate region; other site 592316009270 putative PBP binding loops; other site 592316009271 ABC-ATPase subunit interface; other site 592316009272 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316009273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316009274 dimer interface [polypeptide binding]; other site 592316009275 conserved gate region; other site 592316009276 putative PBP binding loops; other site 592316009277 ABC-ATPase subunit interface; other site 592316009278 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 592316009279 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316009280 substrate binding pocket [chemical binding]; other site 592316009281 membrane-bound complex binding site; other site 592316009282 hinge residues; other site 592316009283 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 592316009284 Flavoprotein; Region: Flavoprotein; pfam02441 592316009285 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 592316009286 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 592316009287 amidophosphoribosyltransferase; Provisional; Region: PRK09246 592316009288 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 592316009289 active site 592316009290 tetramer interface [polypeptide binding]; other site 592316009291 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592316009292 active site 592316009293 colicin V production protein; Provisional; Region: PRK10845 592316009294 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 592316009295 cell division protein DedD; Provisional; Region: PRK11633 592316009296 Sporulation related domain; Region: SPOR; pfam05036 592316009297 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 592316009298 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592316009299 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592316009300 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 592316009301 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 592316009302 hypothetical protein; Provisional; Region: PRK10847 592316009303 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 592316009304 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 592316009305 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 592316009306 dimerization interface 3.5A [polypeptide binding]; other site 592316009307 active site 592316009308 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 592316009309 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 592316009310 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 592316009311 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 592316009312 ligand binding site [chemical binding]; other site 592316009313 NAD binding site [chemical binding]; other site 592316009314 catalytic site [active] 592316009315 homodimer interface [polypeptide binding]; other site 592316009316 Cupin domain; Region: Cupin_2; cl17218 592316009317 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 592316009318 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316009319 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 592316009320 EamA-like transporter family; Region: EamA; pfam00892 592316009321 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 592316009322 sensor protein BasS/PmrB; Provisional; Region: PRK10755 592316009323 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316009324 dimer interface [polypeptide binding]; other site 592316009325 phosphorylation site [posttranslational modification] 592316009326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316009327 ATP binding site [chemical binding]; other site 592316009328 G-X-G motif; other site 592316009329 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 592316009330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316009331 active site 592316009332 phosphorylation site [posttranslational modification] 592316009333 intermolecular recognition site; other site 592316009334 dimerization interface [polypeptide binding]; other site 592316009335 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592316009336 DNA binding site [nucleotide binding] 592316009337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 592316009338 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 592316009339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 592316009340 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 592316009341 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 592316009342 active site residue [active] 592316009343 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 592316009344 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316009345 DNA-binding site [nucleotide binding]; DNA binding site 592316009346 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316009347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316009348 homodimer interface [polypeptide binding]; other site 592316009349 catalytic residue [active] 592316009350 putative transporter; Provisional; Region: PRK12382 592316009351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316009352 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 592316009353 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 592316009354 dimer interface [polypeptide binding]; other site 592316009355 active site 592316009356 Uncharacterized conserved protein [Function unknown]; Region: COG4121 592316009357 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 592316009358 YfcL protein; Region: YfcL; pfam08891 592316009359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 592316009360 hypothetical protein; Provisional; Region: PRK10621 592316009361 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 592316009362 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 592316009363 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 592316009364 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 592316009365 Tetramer interface [polypeptide binding]; other site 592316009366 active site 592316009367 FMN-binding site [chemical binding]; other site 592316009368 HemK family putative methylases; Region: hemK_fam; TIGR00536 592316009369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316009370 S-adenosylmethionine binding site [chemical binding]; other site 592316009371 hypothetical protein; Provisional; Region: PRK04946 592316009372 Smr domain; Region: Smr; pfam01713 592316009373 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 592316009374 catalytic core [active] 592316009375 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 592316009376 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 592316009377 substrate binding site [chemical binding]; other site 592316009378 oxyanion hole (OAH) forming residues; other site 592316009379 trimer interface [polypeptide binding]; other site 592316009380 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 592316009381 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 592316009382 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 592316009383 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 592316009384 dimer interface [polypeptide binding]; other site 592316009385 active site 592316009386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 592316009387 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 592316009388 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 592316009389 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 592316009390 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 592316009391 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592316009392 binding surface 592316009393 TPR motif; other site 592316009394 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 592316009395 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 592316009396 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 592316009397 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 592316009398 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 592316009399 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 592316009400 heme exporter protein CcmC; Region: ccmC; TIGR01191 592316009401 heme exporter protein CcmB; Region: ccmB; TIGR01190 592316009402 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 592316009403 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 592316009404 Walker A/P-loop; other site 592316009405 ATP binding site [chemical binding]; other site 592316009406 Q-loop/lid; other site 592316009407 ABC transporter signature motif; other site 592316009408 Walker B; other site 592316009409 D-loop; other site 592316009410 H-loop/switch region; other site 592316009411 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 592316009412 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592316009413 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 592316009414 EamA-like transporter family; Region: EamA; pfam00892 592316009415 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 592316009416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316009417 putative substrate translocation pore; other site 592316009418 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 592316009419 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 592316009420 Ligand Binding Site [chemical binding]; other site 592316009421 Transcriptional regulator [Transcription]; Region: IclR; COG1414 592316009422 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592316009423 putative DNA binding site [nucleotide binding]; other site 592316009424 putative Zn2+ binding site [ion binding]; other site 592316009425 Bacterial transcriptional regulator; Region: IclR; pfam01614 592316009426 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592316009427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316009428 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 592316009429 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592316009430 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316009431 aminotransferase; Validated; Region: PRK08175 592316009432 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316009433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316009434 homodimer interface [polypeptide binding]; other site 592316009435 catalytic residue [active] 592316009436 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592316009437 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 592316009438 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 592316009439 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 592316009440 GAF domain; Region: GAF_3; pfam13492 592316009441 Histidine kinase; Region: His_kinase; pfam06580 592316009442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316009443 ATP binding site [chemical binding]; other site 592316009444 Mg2+ binding site [ion binding]; other site 592316009445 G-X-G motif; other site 592316009446 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 592316009447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316009448 active site 592316009449 phosphorylation site [posttranslational modification] 592316009450 intermolecular recognition site; other site 592316009451 dimerization interface [polypeptide binding]; other site 592316009452 LytTr DNA-binding domain; Region: LytTR; pfam04397 592316009453 glucokinase, proteobacterial type; Region: glk; TIGR00749 592316009454 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 592316009455 nucleotide binding site [chemical binding]; other site 592316009456 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 592316009457 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 592316009458 dimer interface [polypeptide binding]; other site 592316009459 PYR/PP interface [polypeptide binding]; other site 592316009460 TPP binding site [chemical binding]; other site 592316009461 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 592316009462 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 592316009463 TPP-binding site [chemical binding]; other site 592316009464 dimer interface [polypeptide binding]; other site 592316009465 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592316009466 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592316009467 active site 592316009468 catalytic tetrad [active] 592316009469 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 592316009470 manganese transport protein MntH; Reviewed; Region: PRK00701 592316009471 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 592316009472 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 592316009473 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 592316009474 Nucleoside recognition; Region: Gate; pfam07670 592316009475 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 592316009476 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 592316009477 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 592316009478 dimer interface [polypeptide binding]; other site 592316009479 active site 592316009480 non-prolyl cis peptide bond; other site 592316009481 insertion regions; other site 592316009482 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 592316009483 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316009484 membrane-bound complex binding site; other site 592316009485 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 592316009486 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 592316009487 active site residue [active] 592316009488 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 592316009489 active site residue [active] 592316009490 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 592316009491 active site residue [active] 592316009492 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 592316009493 active site residue [active] 592316009494 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 592316009495 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 592316009496 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 592316009497 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 592316009498 active site 592316009499 HIGH motif; other site 592316009500 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 592316009501 active site 592316009502 KMSKS motif; other site 592316009503 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316009504 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316009505 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 592316009506 putative dimerization interface [polypeptide binding]; other site 592316009507 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 592316009508 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 592316009509 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 592316009510 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 592316009511 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 592316009512 nucleotide binding pocket [chemical binding]; other site 592316009513 K-X-D-G motif; other site 592316009514 catalytic site [active] 592316009515 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 592316009516 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 592316009517 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 592316009518 Dimer interface [polypeptide binding]; other site 592316009519 BRCT sequence motif; other site 592316009520 cell division protein ZipA; Provisional; Region: PRK03427 592316009521 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 592316009522 FtsZ protein binding site [polypeptide binding]; other site 592316009523 putative sulfate transport protein CysZ; Validated; Region: PRK04949 592316009524 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 592316009525 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 592316009526 dimer interface [polypeptide binding]; other site 592316009527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316009528 catalytic residue [active] 592316009529 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 592316009530 dimerization domain swap beta strand [polypeptide binding]; other site 592316009531 regulatory protein interface [polypeptide binding]; other site 592316009532 active site 592316009533 regulatory phosphorylation site [posttranslational modification]; other site 592316009534 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 592316009535 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 592316009536 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 592316009537 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 592316009538 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 592316009539 HPr interaction site; other site 592316009540 glycerol kinase (GK) interaction site [polypeptide binding]; other site 592316009541 active site 592316009542 phosphorylation site [posttranslational modification] 592316009543 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592316009544 dimerization interface [polypeptide binding]; other site 592316009545 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316009546 dimer interface [polypeptide binding]; other site 592316009547 phosphorylation site [posttranslational modification] 592316009548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316009549 ATP binding site [chemical binding]; other site 592316009550 Mg2+ binding site [ion binding]; other site 592316009551 G-X-G motif; other site 592316009552 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592316009553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316009554 active site 592316009555 phosphorylation site [posttranslational modification] 592316009556 intermolecular recognition site; other site 592316009557 dimerization interface [polypeptide binding]; other site 592316009558 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592316009559 DNA binding site [nucleotide binding] 592316009560 cysteine synthase B; Region: cysM; TIGR01138 592316009561 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 592316009562 dimer interface [polypeptide binding]; other site 592316009563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316009564 catalytic residue [active] 592316009565 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 592316009566 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 592316009567 Walker A/P-loop; other site 592316009568 ATP binding site [chemical binding]; other site 592316009569 Q-loop/lid; other site 592316009570 ABC transporter signature motif; other site 592316009571 Walker B; other site 592316009572 D-loop; other site 592316009573 H-loop/switch region; other site 592316009574 TOBE-like domain; Region: TOBE_3; pfam12857 592316009575 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 592316009576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316009577 dimer interface [polypeptide binding]; other site 592316009578 conserved gate region; other site 592316009579 putative PBP binding loops; other site 592316009580 ABC-ATPase subunit interface; other site 592316009581 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 592316009582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316009583 dimer interface [polypeptide binding]; other site 592316009584 conserved gate region; other site 592316009585 putative PBP binding loops; other site 592316009586 ABC-ATPase subunit interface; other site 592316009587 thiosulfate transporter subunit; Provisional; Region: PRK10852 592316009588 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 592316009589 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 592316009590 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 592316009591 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 592316009592 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 592316009593 putative acetyltransferase; Provisional; Region: PRK03624 592316009594 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316009595 Coenzyme A binding pocket [chemical binding]; other site 592316009596 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 592316009597 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 592316009598 active site 592316009599 metal binding site [ion binding]; metal-binding site 592316009600 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 592316009601 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 592316009602 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 592316009603 Malic enzyme, N-terminal domain; Region: malic; pfam00390 592316009604 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 592316009605 putative NAD(P) binding site [chemical binding]; other site 592316009606 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 592316009607 transaldolase-like protein; Provisional; Region: PTZ00411 592316009608 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 592316009609 active site 592316009610 dimer interface [polypeptide binding]; other site 592316009611 catalytic residue [active] 592316009612 transketolase; Reviewed; Region: PRK12753 592316009613 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 592316009614 TPP-binding site [chemical binding]; other site 592316009615 dimer interface [polypeptide binding]; other site 592316009616 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 592316009617 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 592316009618 PYR/PP interface [polypeptide binding]; other site 592316009619 dimer interface [polypeptide binding]; other site 592316009620 TPP binding site [chemical binding]; other site 592316009621 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 592316009622 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 592316009623 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 592316009624 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 592316009625 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 592316009626 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 592316009627 dimer interface [polypeptide binding]; other site 592316009628 ADP-ribose binding site [chemical binding]; other site 592316009629 active site 592316009630 nudix motif; other site 592316009631 metal binding site [ion binding]; metal-binding site 592316009632 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 592316009633 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 592316009634 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 592316009635 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 592316009636 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 592316009637 [4Fe-4S] binding site [ion binding]; other site 592316009638 molybdopterin cofactor binding site; other site 592316009639 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 592316009640 molybdopterin cofactor binding site; other site 592316009641 NapD protein; Region: NapD; cl01163 592316009642 ferredoxin-type protein; Provisional; Region: PRK10194 592316009643 L-asparagine permease; Provisional; Region: PRK15049 592316009644 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 592316009645 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 592316009646 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 592316009647 HAMP domain; Region: HAMP; pfam00672 592316009648 dimerization interface [polypeptide binding]; other site 592316009649 Histidine kinase; Region: HisKA_3; pfam07730 592316009650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316009651 ATP binding site [chemical binding]; other site 592316009652 Mg2+ binding site [ion binding]; other site 592316009653 G-X-G motif; other site 592316009654 transcriptional regulator NarP; Provisional; Region: PRK10403 592316009655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316009656 active site 592316009657 phosphorylation site [posttranslational modification] 592316009658 intermolecular recognition site; other site 592316009659 dimerization interface [polypeptide binding]; other site 592316009660 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592316009661 DNA binding residues [nucleotide binding] 592316009662 dimerization interface [polypeptide binding]; other site 592316009663 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 592316009664 Protein export membrane protein; Region: SecD_SecF; cl14618 592316009665 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 592316009666 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 592316009667 heme binding site [chemical binding]; other site 592316009668 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 592316009669 heme binding site [chemical binding]; other site 592316009670 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 592316009671 ArsC family; Region: ArsC; pfam03960 592316009672 putative catalytic residues [active] 592316009673 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 592316009674 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 592316009675 metal binding site [ion binding]; metal-binding site 592316009676 dimer interface [polypeptide binding]; other site 592316009677 hypothetical protein; Provisional; Region: PRK13664 592316009678 putative hydrolase; Provisional; Region: PRK11460 592316009679 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 592316009680 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 592316009681 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 592316009682 Helicase; Region: Helicase_RecD; pfam05127 592316009683 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 592316009684 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 592316009685 Predicted metalloprotease [General function prediction only]; Region: COG2321 592316009686 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 592316009687 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 592316009688 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 592316009689 ATP binding site [chemical binding]; other site 592316009690 active site 592316009691 substrate binding site [chemical binding]; other site 592316009692 lipoprotein; Provisional; Region: PRK11679 592316009693 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 592316009694 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 592316009695 dihydrodipicolinate synthase; Region: dapA; TIGR00674 592316009696 dimer interface [polypeptide binding]; other site 592316009697 active site 592316009698 catalytic residue [active] 592316009699 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 592316009700 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 592316009701 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 592316009702 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 592316009703 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 592316009704 catalytic triad [active] 592316009705 Domain of unknown function DUF20; Region: UPF0118; pfam01594 592316009706 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 592316009707 Cache domain; Region: Cache_1; pfam02743 592316009708 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592316009709 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316009710 metal binding site [ion binding]; metal-binding site 592316009711 active site 592316009712 I-site; other site 592316009713 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 592316009714 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 592316009715 active site 592316009716 metal binding site [ion binding]; metal-binding site 592316009717 hexamer interface [polypeptide binding]; other site 592316009718 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 592316009719 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316009720 Walker A/P-loop; other site 592316009721 ATP binding site [chemical binding]; other site 592316009722 Q-loop/lid; other site 592316009723 ABC transporter signature motif; other site 592316009724 Walker B; other site 592316009725 D-loop; other site 592316009726 H-loop/switch region; other site 592316009727 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 592316009728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316009729 dimer interface [polypeptide binding]; other site 592316009730 conserved gate region; other site 592316009731 putative PBP binding loops; other site 592316009732 ABC-ATPase subunit interface; other site 592316009733 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 592316009734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316009735 dimer interface [polypeptide binding]; other site 592316009736 conserved gate region; other site 592316009737 putative PBP binding loops; other site 592316009738 ABC-ATPase subunit interface; other site 592316009739 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 592316009740 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 592316009741 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592316009742 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316009743 DNA binding site [nucleotide binding] 592316009744 domain linker motif; other site 592316009745 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 592316009746 DsrE/DsrF-like family; Region: DrsE; pfam02635 592316009747 DsrE/DsrF-like family; Region: DrsE; pfam02635 592316009748 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 592316009749 Peptidase family M48; Region: Peptidase_M48; pfam01435 592316009750 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 592316009751 ArsC family; Region: ArsC; pfam03960 592316009752 catalytic residues [active] 592316009753 DNA replication initiation factor; Provisional; Region: PRK08084 592316009754 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 592316009755 uracil transporter; Provisional; Region: PRK10720 592316009756 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592316009757 active site 592316009758 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 592316009759 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 592316009760 dimerization interface [polypeptide binding]; other site 592316009761 putative ATP binding site [chemical binding]; other site 592316009762 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 592316009763 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 592316009764 active site 592316009765 substrate binding site [chemical binding]; other site 592316009766 cosubstrate binding site; other site 592316009767 catalytic site [active] 592316009768 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 592316009769 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 592316009770 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 592316009771 Walker A/P-loop; other site 592316009772 ATP binding site [chemical binding]; other site 592316009773 Q-loop/lid; other site 592316009774 ABC transporter signature motif; other site 592316009775 Walker B; other site 592316009776 D-loop; other site 592316009777 H-loop/switch region; other site 592316009778 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 592316009779 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 592316009780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316009781 dimer interface [polypeptide binding]; other site 592316009782 conserved gate region; other site 592316009783 putative PBP binding loops; other site 592316009784 ABC-ATPase subunit interface; other site 592316009785 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 592316009786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316009787 ABC-ATPase subunit interface; other site 592316009788 polyphosphate kinase; Provisional; Region: PRK05443 592316009789 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 592316009790 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 592316009791 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 592316009792 domain interface [polypeptide binding]; other site 592316009793 active site 592316009794 catalytic site [active] 592316009795 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 592316009796 domain interface [polypeptide binding]; other site 592316009797 active site 592316009798 catalytic site [active] 592316009799 exopolyphosphatase; Provisional; Region: PRK10854 592316009800 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 592316009801 nucleotide binding site [chemical binding]; other site 592316009802 tellurite resistance protein TehB; Provisional; Region: PRK11207 592316009803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316009804 S-adenosylmethionine binding site [chemical binding]; other site 592316009805 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 592316009806 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 592316009807 MgtE intracellular N domain; Region: MgtE_N; smart00924 592316009808 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 592316009809 Divalent cation transporter; Region: MgtE; cl00786 592316009810 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 592316009811 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 592316009812 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316009813 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 592316009814 dimerization interface [polypeptide binding]; other site 592316009815 substrate binding pocket [chemical binding]; other site 592316009816 EamA-like transporter family; Region: EamA; pfam00892 592316009817 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 592316009818 EamA-like transporter family; Region: EamA; pfam00892 592316009819 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 592316009820 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 592316009821 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 592316009822 GMP synthase; Reviewed; Region: guaA; PRK00074 592316009823 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 592316009824 AMP/PPi binding site [chemical binding]; other site 592316009825 candidate oxyanion hole; other site 592316009826 catalytic triad [active] 592316009827 potential glutamine specificity residues [chemical binding]; other site 592316009828 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 592316009829 ATP Binding subdomain [chemical binding]; other site 592316009830 Ligand Binding sites [chemical binding]; other site 592316009831 Dimerization subdomain; other site 592316009832 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 592316009833 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 592316009834 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 592316009835 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 592316009836 active site 592316009837 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 592316009838 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 592316009839 generic binding surface II; other site 592316009840 generic binding surface I; other site 592316009841 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 592316009842 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 592316009843 active site 592316009844 Zn binding site [ion binding]; other site 592316009845 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 592316009846 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 592316009847 Trp docking motif [polypeptide binding]; other site 592316009848 putative active site [active] 592316009849 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 592316009850 GTP-binding protein Der; Reviewed; Region: PRK00093 592316009851 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 592316009852 G1 box; other site 592316009853 GTP/Mg2+ binding site [chemical binding]; other site 592316009854 Switch I region; other site 592316009855 G2 box; other site 592316009856 Switch II region; other site 592316009857 G3 box; other site 592316009858 G4 box; other site 592316009859 G5 box; other site 592316009860 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 592316009861 G1 box; other site 592316009862 GTP/Mg2+ binding site [chemical binding]; other site 592316009863 Switch I region; other site 592316009864 G2 box; other site 592316009865 G3 box; other site 592316009866 Switch II region; other site 592316009867 G4 box; other site 592316009868 G5 box; other site 592316009869 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 592316009870 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 592316009871 Trp docking motif [polypeptide binding]; other site 592316009872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 592316009873 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 592316009874 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 592316009875 dimer interface [polypeptide binding]; other site 592316009876 motif 1; other site 592316009877 active site 592316009878 motif 2; other site 592316009879 motif 3; other site 592316009880 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 592316009881 anticodon binding site; other site 592316009882 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 592316009883 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 592316009884 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 592316009885 cytoskeletal protein RodZ; Provisional; Region: PRK10856 592316009886 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316009887 non-specific DNA binding site [nucleotide binding]; other site 592316009888 salt bridge; other site 592316009889 sequence-specific DNA binding site [nucleotide binding]; other site 592316009890 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 592316009891 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 592316009892 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 592316009893 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592316009894 FeS/SAM binding site; other site 592316009895 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 592316009896 active site 592316009897 multimer interface [polypeptide binding]; other site 592316009898 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 592316009899 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 592316009900 active site residue [active] 592316009901 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 592316009902 active site residue [active] 592316009903 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 592316009904 aminopeptidase B; Provisional; Region: PRK05015 592316009905 Peptidase; Region: DUF3663; pfam12404 592316009906 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 592316009907 interface (dimer of trimers) [polypeptide binding]; other site 592316009908 Substrate-binding/catalytic site; other site 592316009909 Zn-binding sites [ion binding]; other site 592316009910 cysteine desulfurase; Provisional; Region: PRK14012 592316009911 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 592316009912 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592316009913 catalytic residue [active] 592316009914 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 592316009915 Rrf2 family protein; Region: rrf2_super; TIGR00738 592316009916 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 592316009917 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 592316009918 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 592316009919 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 592316009920 active site 592316009921 dimerization interface [polypeptide binding]; other site 592316009922 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 592316009923 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 592316009924 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 592316009925 PRD domain; Region: PRD; pfam00874 592316009926 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 592316009927 MFS_1 like family; Region: MFS_1_like; pfam12832 592316009928 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 592316009929 classical (c) SDRs; Region: SDR_c; cd05233 592316009930 NAD(P) binding site [chemical binding]; other site 592316009931 active site 592316009932 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 592316009933 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 592316009934 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 592316009935 Creatinine amidohydrolase; Region: Creatininase; pfam02633 592316009936 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316009937 DNA-binding site [nucleotide binding]; DNA binding site 592316009938 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592316009939 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 592316009940 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316009941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316009942 dimer interface [polypeptide binding]; other site 592316009943 conserved gate region; other site 592316009944 putative PBP binding loops; other site 592316009945 ABC-ATPase subunit interface; other site 592316009946 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 592316009947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 592316009948 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 592316009949 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316009950 Walker A/P-loop; other site 592316009951 ATP binding site [chemical binding]; other site 592316009952 Q-loop/lid; other site 592316009953 ABC transporter signature motif; other site 592316009954 Walker B; other site 592316009955 D-loop; other site 592316009956 H-loop/switch region; other site 592316009957 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 592316009958 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316009959 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 592316009960 Walker A/P-loop; other site 592316009961 ATP binding site [chemical binding]; other site 592316009962 Q-loop/lid; other site 592316009963 ABC transporter signature motif; other site 592316009964 Walker B; other site 592316009965 D-loop; other site 592316009966 H-loop/switch region; other site 592316009967 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 592316009968 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 592316009969 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 592316009970 dimer interface [polypeptide binding]; other site 592316009971 active site 592316009972 glycine-pyridoxal phosphate binding site [chemical binding]; other site 592316009973 folate binding site [chemical binding]; other site 592316009974 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 592316009975 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 592316009976 heme-binding site [chemical binding]; other site 592316009977 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 592316009978 FAD binding pocket [chemical binding]; other site 592316009979 FAD binding motif [chemical binding]; other site 592316009980 phosphate binding motif [ion binding]; other site 592316009981 beta-alpha-beta structure motif; other site 592316009982 NAD binding pocket [chemical binding]; other site 592316009983 Heme binding pocket [chemical binding]; other site 592316009984 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 592316009985 Nitrogen regulatory protein P-II; Region: P-II; smart00938 592316009986 response regulator GlrR; Provisional; Region: PRK15115 592316009987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316009988 active site 592316009989 phosphorylation site [posttranslational modification] 592316009990 intermolecular recognition site; other site 592316009991 dimerization interface [polypeptide binding]; other site 592316009992 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316009993 Walker A motif; other site 592316009994 ATP binding site [chemical binding]; other site 592316009995 Walker B motif; other site 592316009996 arginine finger; other site 592316009997 hypothetical protein; Provisional; Region: PRK10722 592316009998 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592316009999 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316010000 dimer interface [polypeptide binding]; other site 592316010001 phosphorylation site [posttranslational modification] 592316010002 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316010003 ATP binding site [chemical binding]; other site 592316010004 Mg2+ binding site [ion binding]; other site 592316010005 G-X-G motif; other site 592316010006 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 592316010007 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 592316010008 dimerization interface [polypeptide binding]; other site 592316010009 ATP binding site [chemical binding]; other site 592316010010 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 592316010011 dimerization interface [polypeptide binding]; other site 592316010012 ATP binding site [chemical binding]; other site 592316010013 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 592316010014 putative active site [active] 592316010015 catalytic triad [active] 592316010016 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 592316010017 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316010018 substrate binding pocket [chemical binding]; other site 592316010019 membrane-bound complex binding site; other site 592316010020 hinge residues; other site 592316010021 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 592316010022 N-acetyl-D-glucosamine binding site [chemical binding]; other site 592316010023 catalytic residue [active] 592316010024 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 592316010025 nucleoside/Zn binding site; other site 592316010026 dimer interface [polypeptide binding]; other site 592316010027 catalytic motif [active] 592316010028 hypothetical protein; Provisional; Region: PRK11590 592316010029 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 592316010030 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 592316010031 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 592316010032 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 592316010033 putative active site [active] 592316010034 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592316010035 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 592316010036 active site 592316010037 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 592316010038 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 592316010039 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 592316010040 active site 592316010041 hydrophilic channel; other site 592316010042 dimerization interface [polypeptide binding]; other site 592316010043 catalytic residues [active] 592316010044 active site lid [active] 592316010045 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 592316010046 Recombination protein O N terminal; Region: RecO_N; pfam11967 592316010047 Recombination protein O C terminal; Region: RecO_C; pfam02565 592316010048 GTPase Era; Reviewed; Region: era; PRK00089 592316010049 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 592316010050 G1 box; other site 592316010051 GTP/Mg2+ binding site [chemical binding]; other site 592316010052 Switch I region; other site 592316010053 G2 box; other site 592316010054 Switch II region; other site 592316010055 G3 box; other site 592316010056 G4 box; other site 592316010057 G5 box; other site 592316010058 KH domain; Region: KH_2; pfam07650 592316010059 ribonuclease III; Reviewed; Region: rnc; PRK00102 592316010060 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 592316010061 dimerization interface [polypeptide binding]; other site 592316010062 active site 592316010063 metal binding site [ion binding]; metal-binding site 592316010064 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 592316010065 dsRNA binding site [nucleotide binding]; other site 592316010066 signal peptidase I; Provisional; Region: PRK10861 592316010067 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 592316010068 Catalytic site [active] 592316010069 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 592316010070 GTP-binding protein LepA; Provisional; Region: PRK05433 592316010071 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 592316010072 G1 box; other site 592316010073 putative GEF interaction site [polypeptide binding]; other site 592316010074 GTP/Mg2+ binding site [chemical binding]; other site 592316010075 Switch I region; other site 592316010076 G2 box; other site 592316010077 G3 box; other site 592316010078 Switch II region; other site 592316010079 G4 box; other site 592316010080 G5 box; other site 592316010081 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 592316010082 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 592316010083 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 592316010084 SoxR reducing system protein RseC; Provisional; Region: PRK10862 592316010085 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 592316010086 anti-sigma E factor; Provisional; Region: rseB; PRK09455 592316010087 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 592316010088 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 592316010089 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 592316010090 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 592316010091 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592316010092 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592316010093 DNA binding residues [nucleotide binding] 592316010094 L-aspartate oxidase; Provisional; Region: PRK09077 592316010095 L-aspartate oxidase; Provisional; Region: PRK06175 592316010096 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 592316010097 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 592316010098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316010099 S-adenosylmethionine binding site [chemical binding]; other site 592316010100 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 592316010101 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 592316010102 ATP binding site [chemical binding]; other site 592316010103 Mg++ binding site [ion binding]; other site 592316010104 motif III; other site 592316010105 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592316010106 nucleotide binding region [chemical binding]; other site 592316010107 ATP-binding site [chemical binding]; other site 592316010108 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 592316010109 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 592316010110 ligand binding site [chemical binding]; other site 592316010111 active site 592316010112 UGI interface [polypeptide binding]; other site 592316010113 catalytic site [active] 592316010114 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 592316010115 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 592316010116 dimer interface [polypeptide binding]; other site 592316010117 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 592316010118 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 592316010119 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 592316010120 recombination and repair protein; Provisional; Region: PRK10869 592316010121 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 592316010122 Walker A/P-loop; other site 592316010123 ATP binding site [chemical binding]; other site 592316010124 Q-loop/lid; other site 592316010125 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 592316010126 Q-loop/lid; other site 592316010127 ABC transporter signature motif; other site 592316010128 Walker B; other site 592316010129 D-loop; other site 592316010130 H-loop/switch region; other site 592316010131 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 592316010132 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 592316010133 hypothetical protein; Validated; Region: PRK01777 592316010134 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 592316010135 putative coenzyme Q binding site [chemical binding]; other site 592316010136 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 592316010137 SmpB-tmRNA interface; other site 592316010138 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 592316010139 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 592316010140 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 592316010141 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 592316010142 shikimate binding site; other site 592316010143 NAD(P) binding site [chemical binding]; other site 592316010144 hypothetical protein; Validated; Region: PRK08238 592316010145 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 592316010146 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 592316010147 FAD binding domain; Region: FAD_binding_4; pfam01565 592316010148 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 592316010149 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 592316010150 classical (c) SDRs; Region: SDR_c; cd05233 592316010151 NAD(P) binding site [chemical binding]; other site 592316010152 active site 592316010153 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 592316010154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316010155 NAD(P) binding site [chemical binding]; other site 592316010156 active site 592316010157 hypothetical protein; Provisional; Region: PRK07233 592316010158 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592316010159 Predicted membrane protein [Function unknown]; Region: COG2246 592316010160 GtrA-like protein; Region: GtrA; pfam04138 592316010161 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 592316010162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 592316010163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 592316010164 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316010165 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 592316010166 magnesium-transporting ATPase; Provisional; Region: PRK15122 592316010167 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 592316010168 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 592316010169 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 592316010170 Soluble P-type ATPase [General function prediction only]; Region: COG4087 592316010171 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 592316010172 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592316010173 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 592316010174 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316010175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316010176 putative PBP binding loops; other site 592316010177 dimer interface [polypeptide binding]; other site 592316010178 ABC-ATPase subunit interface; other site 592316010179 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 592316010180 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 592316010181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316010182 dimer interface [polypeptide binding]; other site 592316010183 conserved gate region; other site 592316010184 putative PBP binding loops; other site 592316010185 ABC-ATPase subunit interface; other site 592316010186 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 592316010187 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316010188 Walker A/P-loop; other site 592316010189 ATP binding site [chemical binding]; other site 592316010190 Q-loop/lid; other site 592316010191 ABC transporter signature motif; other site 592316010192 Walker B; other site 592316010193 D-loop; other site 592316010194 H-loop/switch region; other site 592316010195 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316010196 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 592316010197 Walker A/P-loop; other site 592316010198 ATP binding site [chemical binding]; other site 592316010199 Q-loop/lid; other site 592316010200 ABC transporter signature motif; other site 592316010201 Walker B; other site 592316010202 D-loop; other site 592316010203 H-loop/switch region; other site 592316010204 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 592316010205 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 592316010206 Walker A/P-loop; other site 592316010207 ATP binding site [chemical binding]; other site 592316010208 Q-loop/lid; other site 592316010209 ABC transporter signature motif; other site 592316010210 Walker B; other site 592316010211 D-loop; other site 592316010212 H-loop/switch region; other site 592316010213 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 592316010214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316010215 dimer interface [polypeptide binding]; other site 592316010216 conserved gate region; other site 592316010217 putative PBP binding loops; other site 592316010218 ABC-ATPase subunit interface; other site 592316010219 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 592316010220 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 592316010221 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 592316010222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316010223 Coenzyme A binding pocket [chemical binding]; other site 592316010224 PEGA domain; Region: PEGA; pfam08308 592316010225 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 592316010226 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 592316010227 S-methylmethionine transporter; Provisional; Region: PRK11387 592316010228 hypothetical protein; Provisional; Region: PRK10556 592316010229 hypothetical protein; Provisional; Region: PRK10556 592316010230 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 592316010231 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 592316010232 catalytic residues [active] 592316010233 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 592316010234 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 592316010235 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 592316010236 Class I ribonucleotide reductase; Region: RNR_I; cd01679 592316010237 active site 592316010238 dimer interface [polypeptide binding]; other site 592316010239 catalytic residues [active] 592316010240 effector binding site; other site 592316010241 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 592316010242 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 592316010243 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 592316010244 dimer interface [polypeptide binding]; other site 592316010245 putative radical transfer pathway; other site 592316010246 diiron center [ion binding]; other site 592316010247 tyrosyl radical; other site 592316010248 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 592316010249 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 592316010250 Walker A/P-loop; other site 592316010251 ATP binding site [chemical binding]; other site 592316010252 Q-loop/lid; other site 592316010253 ABC transporter signature motif; other site 592316010254 Walker B; other site 592316010255 D-loop; other site 592316010256 H-loop/switch region; other site 592316010257 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 592316010258 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 592316010259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316010260 dimer interface [polypeptide binding]; other site 592316010261 conserved gate region; other site 592316010262 putative PBP binding loops; other site 592316010263 ABC-ATPase subunit interface; other site 592316010264 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 592316010265 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 592316010266 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 592316010267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316010268 transcriptional repressor MprA; Provisional; Region: PRK10870 592316010269 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592316010270 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 592316010271 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592316010272 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316010273 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 592316010274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316010275 putative substrate translocation pore; other site 592316010276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316010277 putative methyltransferase; Provisional; Region: PRK10864 592316010278 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 592316010279 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 592316010280 thioredoxin 2; Provisional; Region: PRK10996 592316010281 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 592316010282 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 592316010283 catalytic residues [active] 592316010284 Uncharacterized conserved protein [Function unknown]; Region: COG3148 592316010285 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 592316010286 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 592316010287 CoA binding domain; Region: CoA_binding_2; pfam13380 592316010288 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 592316010289 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 592316010290 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592316010291 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 592316010292 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 592316010293 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 592316010294 domain interface [polypeptide binding]; other site 592316010295 putative active site [active] 592316010296 catalytic site [active] 592316010297 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 592316010298 domain interface [polypeptide binding]; other site 592316010299 putative active site [active] 592316010300 catalytic site [active] 592316010301 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 592316010302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316010303 putative substrate translocation pore; other site 592316010304 protein disaggregation chaperone; Provisional; Region: PRK10865 592316010305 Clp amino terminal domain; Region: Clp_N; pfam02861 592316010306 Clp amino terminal domain; Region: Clp_N; pfam02861 592316010307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316010308 Walker A motif; other site 592316010309 ATP binding site [chemical binding]; other site 592316010310 Walker B motif; other site 592316010311 arginine finger; other site 592316010312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316010313 Walker A motif; other site 592316010314 ATP binding site [chemical binding]; other site 592316010315 Walker B motif; other site 592316010316 arginine finger; other site 592316010317 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 592316010318 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 592316010319 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 592316010320 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 592316010321 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592316010322 RNA binding surface [nucleotide binding]; other site 592316010323 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 592316010324 active site 592316010325 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 592316010326 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 592316010327 30S subunit binding site; other site 592316010328 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 592316010329 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 592316010330 Prephenate dehydratase; Region: PDT; pfam00800 592316010331 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 592316010332 putative L-Phe binding site [chemical binding]; other site 592316010333 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 592316010334 Chorismate mutase type II; Region: CM_2; cl00693 592316010335 prephenate dehydrogenase; Validated; Region: PRK08507 592316010336 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 592316010337 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 592316010338 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592316010339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592316010340 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 592316010341 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 592316010342 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 592316010343 RimM N-terminal domain; Region: RimM; pfam01782 592316010344 PRC-barrel domain; Region: PRC; pfam05239 592316010345 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 592316010346 signal recognition particle protein; Provisional; Region: PRK10867 592316010347 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 592316010348 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 592316010349 P loop; other site 592316010350 GTP binding site [chemical binding]; other site 592316010351 Signal peptide binding domain; Region: SRP_SPB; pfam02978 592316010352 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 592316010353 hypothetical protein; Provisional; Region: PRK11573 592316010354 Domain of unknown function DUF21; Region: DUF21; pfam01595 592316010355 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 592316010356 Transporter associated domain; Region: CorC_HlyC; smart01091 592316010357 S-ribosylhomocysteinase; Provisional; Region: PRK02260 592316010358 glutamate--cysteine ligase; Provisional; Region: PRK02107 592316010359 Predicted membrane protein [Function unknown]; Region: COG1238 592316010360 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 592316010361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316010362 motif II; other site 592316010363 carbon storage regulator; Provisional; Region: PRK01712 592316010364 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 592316010365 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 592316010366 motif 1; other site 592316010367 active site 592316010368 motif 2; other site 592316010369 motif 3; other site 592316010370 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 592316010371 DHHA1 domain; Region: DHHA1; pfam02272 592316010372 recombination regulator RecX; Reviewed; Region: recX; PRK00117 592316010373 recombinase A; Provisional; Region: recA; PRK09354 592316010374 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 592316010375 hexamer interface [polypeptide binding]; other site 592316010376 Walker A motif; other site 592316010377 ATP binding site [chemical binding]; other site 592316010378 Walker B motif; other site 592316010379 hypothetical protein; Validated; Region: PRK03661 592316010380 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 592316010381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316010382 S-adenosylmethionine binding site [chemical binding]; other site 592316010383 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 592316010384 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 592316010385 inhibitor site; inhibition site 592316010386 active site 592316010387 dimer interface [polypeptide binding]; other site 592316010388 catalytic residue [active] 592316010389 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 592316010390 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 592316010391 PhnA protein; Region: PhnA; pfam03831 592316010392 Transglycosylase SLT domain; Region: SLT_2; pfam13406 592316010393 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 592316010394 N-acetyl-D-glucosamine binding site [chemical binding]; other site 592316010395 catalytic residue [active] 592316010396 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 592316010397 MutS domain I; Region: MutS_I; pfam01624 592316010398 MutS domain II; Region: MutS_II; pfam05188 592316010399 MutS domain III; Region: MutS_III; pfam05192 592316010400 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 592316010401 Walker A/P-loop; other site 592316010402 ATP binding site [chemical binding]; other site 592316010403 Q-loop/lid; other site 592316010404 ABC transporter signature motif; other site 592316010405 Walker B; other site 592316010406 D-loop; other site 592316010407 H-loop/switch region; other site 592316010408 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 592316010409 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 592316010410 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592316010411 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 592316010412 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592316010413 DNA binding residues [nucleotide binding] 592316010414 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 592316010415 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592316010416 Peptidase family M23; Region: Peptidase_M23; pfam01551 592316010417 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 592316010418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316010419 S-adenosylmethionine binding site [chemical binding]; other site 592316010420 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 592316010421 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 592316010422 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 592316010423 Permutation of conserved domain; other site 592316010424 active site 592316010425 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 592316010426 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 592316010427 homotrimer interaction site [polypeptide binding]; other site 592316010428 zinc binding site [ion binding]; other site 592316010429 CDP-binding sites; other site 592316010430 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 592316010431 substrate binding site; other site 592316010432 dimer interface; other site 592316010433 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 592316010434 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 592316010435 hypothetical protein; Provisional; Region: PRK10726 592316010436 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 592316010437 ligand-binding site [chemical binding]; other site 592316010438 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 592316010439 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 592316010440 CysD dimerization site [polypeptide binding]; other site 592316010441 G1 box; other site 592316010442 putative GEF interaction site [polypeptide binding]; other site 592316010443 GTP/Mg2+ binding site [chemical binding]; other site 592316010444 Switch I region; other site 592316010445 G2 box; other site 592316010446 G3 box; other site 592316010447 Switch II region; other site 592316010448 G4 box; other site 592316010449 G5 box; other site 592316010450 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 592316010451 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 592316010452 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 592316010453 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 592316010454 Active Sites [active] 592316010455 siroheme synthase; Provisional; Region: cysG; PRK10637 592316010456 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 592316010457 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 592316010458 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 592316010459 active site 592316010460 SAM binding site [chemical binding]; other site 592316010461 homodimer interface [polypeptide binding]; other site 592316010462 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 592316010463 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 592316010464 metal binding site [ion binding]; metal-binding site 592316010465 YCII-related domain; Region: YCII; cl00999 592316010466 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 592316010467 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 592316010468 Active Sites [active] 592316010469 sulfite reductase subunit beta; Provisional; Region: PRK13504 592316010470 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 592316010471 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 592316010472 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 592316010473 Flavodoxin; Region: Flavodoxin_1; pfam00258 592316010474 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 592316010475 FAD binding pocket [chemical binding]; other site 592316010476 FAD binding motif [chemical binding]; other site 592316010477 catalytic residues [active] 592316010478 NAD binding pocket [chemical binding]; other site 592316010479 phosphate binding motif [ion binding]; other site 592316010480 beta-alpha-beta structure motif; other site 592316010481 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 592316010482 active site 592316010483 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 592316010484 dimer interface [polypeptide binding]; other site 592316010485 substrate binding site [chemical binding]; other site 592316010486 metal binding sites [ion binding]; metal-binding site 592316010487 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 592316010488 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 592316010489 enolase; Provisional; Region: eno; PRK00077 592316010490 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 592316010491 dimer interface [polypeptide binding]; other site 592316010492 metal binding site [ion binding]; metal-binding site 592316010493 substrate binding pocket [chemical binding]; other site 592316010494 CTP synthetase; Validated; Region: pyrG; PRK05380 592316010495 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 592316010496 Catalytic site [active] 592316010497 active site 592316010498 UTP binding site [chemical binding]; other site 592316010499 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 592316010500 active site 592316010501 putative oxyanion hole; other site 592316010502 catalytic triad [active] 592316010503 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 592316010504 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 592316010505 homodimer interface [polypeptide binding]; other site 592316010506 metal binding site [ion binding]; metal-binding site 592316010507 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 592316010508 homodimer interface [polypeptide binding]; other site 592316010509 active site 592316010510 putative chemical substrate binding site [chemical binding]; other site 592316010511 metal binding site [ion binding]; metal-binding site 592316010512 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 592316010513 HD domain; Region: HD_4; pfam13328 592316010514 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 592316010515 synthetase active site [active] 592316010516 NTP binding site [chemical binding]; other site 592316010517 metal binding site [ion binding]; metal-binding site 592316010518 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 592316010519 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 592316010520 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 592316010521 TRAM domain; Region: TRAM; pfam01938 592316010522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316010523 S-adenosylmethionine binding site [chemical binding]; other site 592316010524 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 592316010525 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 592316010526 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592316010527 dimerization interface [polypeptide binding]; other site 592316010528 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316010529 dimer interface [polypeptide binding]; other site 592316010530 phosphorylation site [posttranslational modification] 592316010531 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316010532 ATP binding site [chemical binding]; other site 592316010533 Mg2+ binding site [ion binding]; other site 592316010534 G-X-G motif; other site 592316010535 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 592316010536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316010537 active site 592316010538 phosphorylation site [posttranslational modification] 592316010539 intermolecular recognition site; other site 592316010540 dimerization interface [polypeptide binding]; other site 592316010541 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 592316010542 putative binding surface; other site 592316010543 active site 592316010544 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 592316010545 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 592316010546 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 592316010547 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 592316010548 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 592316010549 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 592316010550 active site 592316010551 tetramer interface [polypeptide binding]; other site 592316010552 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 592316010553 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 592316010554 active site 592316010555 tetramer interface [polypeptide binding]; other site 592316010556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316010557 D-galactonate transporter; Region: 2A0114; TIGR00893 592316010558 putative substrate translocation pore; other site 592316010559 galactarate dehydratase; Region: galactar-dH20; TIGR03248 592316010560 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 592316010561 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 592316010562 flavodoxin; Provisional; Region: PRK08105 592316010563 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 592316010564 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 592316010565 probable active site [active] 592316010566 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 592316010567 SecY interacting protein Syd; Provisional; Region: PRK04968 592316010568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 592316010569 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 592316010570 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 592316010571 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 592316010572 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 592316010573 flap endonuclease-like protein; Provisional; Region: PRK09482 592316010574 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 592316010575 active site 592316010576 metal binding site 1 [ion binding]; metal-binding site 592316010577 putative 5' ssDNA interaction site; other site 592316010578 metal binding site 3; metal-binding site 592316010579 metal binding site 2 [ion binding]; metal-binding site 592316010580 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 592316010581 putative DNA binding site [nucleotide binding]; other site 592316010582 putative metal binding site [ion binding]; other site 592316010583 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 592316010584 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 592316010585 hypothetical protein; Provisional; Region: PRK10873 592316010586 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 592316010587 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316010588 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 592316010589 dimerization interface [polypeptide binding]; other site 592316010590 substrate binding pocket [chemical binding]; other site 592316010591 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 592316010592 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 592316010593 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 592316010594 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592316010595 catalytic residue [active] 592316010596 cysteine desulfurase, sulfur acceptor subunit CsdE; Region: FeS_syn_CsdE; TIGR03391 592316010597 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 592316010598 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 592316010599 putative ATP binding site [chemical binding]; other site 592316010600 putative substrate interface [chemical binding]; other site 592316010601 murein transglycosylase A; Provisional; Region: mltA; PRK11162 592316010602 MltA specific insert domain; Region: MltA; smart00925 592316010603 3D domain; Region: 3D; pfam06725 592316010604 AMIN domain; Region: AMIN; pfam11741 592316010605 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 592316010606 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 592316010607 active site 592316010608 metal binding site [ion binding]; metal-binding site 592316010609 N-acetylglutamate synthase; Validated; Region: PRK05279 592316010610 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 592316010611 putative feedback inhibition sensing region; other site 592316010612 putative nucleotide binding site [chemical binding]; other site 592316010613 putative substrate binding site [chemical binding]; other site 592316010614 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316010615 Coenzyme A binding pocket [chemical binding]; other site 592316010616 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 592316010617 AAA domain; Region: AAA_30; pfam13604 592316010618 Family description; Region: UvrD_C_2; pfam13538 592316010619 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 592316010620 protease3; Provisional; Region: PRK15101 592316010621 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 592316010622 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 592316010623 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 592316010624 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 592316010625 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 592316010626 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 592316010627 hypothetical protein; Provisional; Region: PRK10557 592316010628 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 592316010629 hypothetical protein; Provisional; Region: PRK10506 592316010630 thymidylate synthase; Reviewed; Region: thyA; PRK01827 592316010631 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 592316010632 dimerization interface [polypeptide binding]; other site 592316010633 active site 592316010634 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 592316010635 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 592316010636 GAF domain; Region: GAF; pfam01590 592316010637 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 592316010638 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 592316010639 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 592316010640 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 592316010641 putative active site [active] 592316010642 Ap4A binding site [chemical binding]; other site 592316010643 nudix motif; other site 592316010644 putative metal binding site [ion binding]; other site 592316010645 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 592316010646 putative DNA-binding cleft [nucleotide binding]; other site 592316010647 putative DNA clevage site; other site 592316010648 molecular lever; other site 592316010649 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 592316010650 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 592316010651 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592316010652 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592316010653 active site 592316010654 catalytic tetrad [active] 592316010655 lysophospholipid transporter LplT; Provisional; Region: PRK11195 592316010656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316010657 putative substrate translocation pore; other site 592316010658 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 592316010659 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 592316010660 putative acyl-acceptor binding pocket; other site 592316010661 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 592316010662 acyl-activating enzyme (AAE) consensus motif; other site 592316010663 putative AMP binding site [chemical binding]; other site 592316010664 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 592316010665 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 592316010666 Protein export membrane protein; Region: SecD_SecF; cl14618 592316010667 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 592316010668 Protein export membrane protein; Region: SecD_SecF; cl14618 592316010669 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 592316010670 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592316010671 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316010672 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 592316010673 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 592316010674 Protein export membrane protein; Region: SecD_SecF; cl14618 592316010675 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 592316010676 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592316010677 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316010678 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 592316010679 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 592316010680 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 592316010681 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 592316010682 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 592316010683 molybdopterin cofactor binding site [chemical binding]; other site 592316010684 substrate binding site [chemical binding]; other site 592316010685 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 592316010686 molybdopterin cofactor binding site; other site 592316010687 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 592316010688 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316010689 DNA binding site [nucleotide binding] 592316010690 domain linker motif; other site 592316010691 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 592316010692 dimerization interface (closed form) [polypeptide binding]; other site 592316010693 ligand binding site [chemical binding]; other site 592316010694 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 592316010695 HAMP domain; Region: HAMP; pfam00672 592316010696 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592316010697 dimer interface [polypeptide binding]; other site 592316010698 putative CheW interface [polypeptide binding]; other site 592316010699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316010700 Coenzyme A binding pocket [chemical binding]; other site 592316010701 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 592316010702 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316010703 DNA-binding site [nucleotide binding]; DNA binding site 592316010704 FCD domain; Region: FCD; pfam07729 592316010705 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 592316010706 active site 592316010707 P-loop; other site 592316010708 phosphorylation site [posttranslational modification] 592316010709 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 592316010710 beta-galactosidase; Region: BGL; TIGR03356 592316010711 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 592316010712 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 592316010713 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 592316010714 active site 592316010715 methionine cluster; other site 592316010716 phosphorylation site [posttranslational modification] 592316010717 metal binding site [ion binding]; metal-binding site 592316010718 diaminopimelate decarboxylase; Provisional; Region: PRK11165 592316010719 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 592316010720 active site 592316010721 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 592316010722 substrate binding site [chemical binding]; other site 592316010723 catalytic residues [active] 592316010724 dimer interface [polypeptide binding]; other site 592316010725 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 592316010726 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316010727 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316010728 dimerization interface [polypeptide binding]; other site 592316010729 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 592316010730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316010731 putative substrate translocation pore; other site 592316010732 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 592316010733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 592316010734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316010735 putative PBP binding loops; other site 592316010736 dimer interface [polypeptide binding]; other site 592316010737 ABC-ATPase subunit interface; other site 592316010738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316010739 dimer interface [polypeptide binding]; other site 592316010740 conserved gate region; other site 592316010741 putative PBP binding loops; other site 592316010742 ABC-ATPase subunit interface; other site 592316010743 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 592316010744 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 592316010745 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 592316010746 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 592316010747 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316010748 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316010749 substrate binding pocket [chemical binding]; other site 592316010750 membrane-bound complex binding site; other site 592316010751 hinge residues; other site 592316010752 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 592316010753 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 592316010754 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 592316010755 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 592316010756 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 592316010757 dimer interface [polypeptide binding]; other site 592316010758 putative anticodon binding site; other site 592316010759 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 592316010760 motif 1; other site 592316010761 active site 592316010762 motif 2; other site 592316010763 motif 3; other site 592316010764 peptide chain release factor 2; Validated; Region: prfB; PRK00578 592316010765 This domain is found in peptide chain release factors; Region: PCRF; smart00937 592316010766 RF-1 domain; Region: RF-1; pfam00472 592316010767 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 592316010768 DHH family; Region: DHH; pfam01368 592316010769 DHHA1 domain; Region: DHHA1; pfam02272 592316010770 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 592316010771 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 592316010772 dimerization domain [polypeptide binding]; other site 592316010773 dimer interface [polypeptide binding]; other site 592316010774 catalytic residues [active] 592316010775 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 592316010776 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 592316010777 active site 592316010778 Int/Topo IB signature motif; other site 592316010779 flavodoxin FldB; Provisional; Region: PRK12359 592316010780 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 592316010781 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 592316010782 putative global regulator; Reviewed; Region: PRK09559 592316010783 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 592316010784 hemolysin; Provisional; Region: PRK15087 592316010785 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 592316010786 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 592316010787 classical (c) SDRs; Region: SDR_c; cd05233 592316010788 NAD(P) binding site [chemical binding]; other site 592316010789 active site 592316010790 glycine dehydrogenase; Provisional; Region: PRK05367 592316010791 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 592316010792 tetramer interface [polypeptide binding]; other site 592316010793 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316010794 catalytic residue [active] 592316010795 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 592316010796 tetramer interface [polypeptide binding]; other site 592316010797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316010798 catalytic residue [active] 592316010799 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 592316010800 lipoyl attachment site [posttranslational modification]; other site 592316010801 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 592316010802 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 592316010803 oxidoreductase; Provisional; Region: PRK08013 592316010804 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 592316010805 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 592316010806 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 592316010807 proline aminopeptidase P II; Provisional; Region: PRK10879 592316010808 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 592316010809 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 592316010810 active site 592316010811 hypothetical protein; Reviewed; Region: PRK01736 592316010812 Z-ring-associated protein; Provisional; Region: PRK10972 592316010813 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 592316010814 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 592316010815 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 592316010816 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 592316010817 ligand binding site [chemical binding]; other site 592316010818 NAD binding site [chemical binding]; other site 592316010819 tetramer interface [polypeptide binding]; other site 592316010820 catalytic site [active] 592316010821 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 592316010822 L-serine binding site [chemical binding]; other site 592316010823 ACT domain interface; other site 592316010824 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 592316010825 tetramer (dimer of dimers) interface [polypeptide binding]; other site 592316010826 active site 592316010827 dimer interface [polypeptide binding]; other site 592316010828 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 592316010829 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316010830 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 592316010831 putative dimerization interface [polypeptide binding]; other site 592316010832 Uncharacterized conserved protein [Function unknown]; Region: COG2968 592316010833 oxidative stress defense protein; Provisional; Region: PRK11087 592316010834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316010835 D-galactonate transporter; Region: 2A0114; TIGR00893 592316010836 putative substrate translocation pore; other site 592316010837 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 592316010838 Transcriptional regulator [Transcription]; Region: IclR; COG1414 592316010839 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 592316010840 arginine exporter protein; Provisional; Region: PRK09304 592316010841 mechanosensitive channel MscS; Provisional; Region: PRK10334 592316010842 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592316010843 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 592316010844 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 592316010845 active site 592316010846 intersubunit interface [polypeptide binding]; other site 592316010847 zinc binding site [ion binding]; other site 592316010848 Na+ binding site [ion binding]; other site 592316010849 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 592316010850 Phosphoglycerate kinase; Region: PGK; pfam00162 592316010851 substrate binding site [chemical binding]; other site 592316010852 hinge regions; other site 592316010853 ADP binding site [chemical binding]; other site 592316010854 catalytic site [active] 592316010855 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 592316010856 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 592316010857 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 592316010858 transketolase; Reviewed; Region: PRK12753 592316010859 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 592316010860 TPP-binding site [chemical binding]; other site 592316010861 dimer interface [polypeptide binding]; other site 592316010862 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 592316010863 PYR/PP interface [polypeptide binding]; other site 592316010864 dimer interface [polypeptide binding]; other site 592316010865 TPP binding site [chemical binding]; other site 592316010866 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 592316010867 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 592316010868 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 592316010869 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 592316010870 agmatinase; Region: agmatinase; TIGR01230 592316010871 oligomer interface [polypeptide binding]; other site 592316010872 putative active site [active] 592316010873 Mn binding site [ion binding]; other site 592316010874 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 592316010875 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316010876 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 592316010877 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592316010878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316010879 Walker A/P-loop; other site 592316010880 ATP binding site [chemical binding]; other site 592316010881 Q-loop/lid; other site 592316010882 ABC transporter signature motif; other site 592316010883 Walker B; other site 592316010884 D-loop; other site 592316010885 H-loop/switch region; other site 592316010886 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 592316010887 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010888 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010889 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010890 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010891 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010892 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010893 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010894 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010895 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010896 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010897 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010898 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010899 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010900 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010901 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010902 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010903 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010904 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010905 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010906 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010907 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010908 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010909 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010910 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010911 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010912 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010913 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010914 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010915 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010916 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010917 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010918 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 592316010919 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 592316010920 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592316010921 arginine decarboxylase; Provisional; Region: PRK05354 592316010922 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 592316010923 dimer interface [polypeptide binding]; other site 592316010924 active site 592316010925 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 592316010926 catalytic residues [active] 592316010927 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 592316010928 S-adenosylmethionine synthetase; Validated; Region: PRK05250 592316010929 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 592316010930 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 592316010931 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 592316010932 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 592316010933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316010934 putative substrate translocation pore; other site 592316010935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316010936 hypothetical protein; Provisional; Region: PRK04860 592316010937 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 592316010938 DNA-specific endonuclease I; Provisional; Region: PRK15137 592316010939 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 592316010940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 592316010941 RNA methyltransferase, RsmE family; Region: TIGR00046 592316010942 glutathione synthetase; Provisional; Region: PRK05246 592316010943 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 592316010944 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 592316010945 hypothetical protein; Validated; Region: PRK00228 592316010946 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 592316010947 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 592316010948 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 592316010949 Walker A motif; other site 592316010950 ATP binding site [chemical binding]; other site 592316010951 Walker B motif; other site 592316010952 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 592316010953 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 592316010954 catalytic residue [active] 592316010955 YGGT family; Region: YGGT; pfam02325 592316010956 Predicted integral membrane protein [Function unknown]; Region: COG0762 592316010957 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 592316010958 active site 592316010959 dimerization interface [polypeptide binding]; other site 592316010960 HemN family oxidoreductase; Provisional; Region: PRK05660 592316010961 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592316010962 FeS/SAM binding site; other site 592316010963 HemN C-terminal domain; Region: HemN_C; pfam06969 592316010964 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316010965 DNA-binding site [nucleotide binding]; DNA binding site 592316010966 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 592316010967 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 592316010968 transketolase; Reviewed; Region: PRK12753 592316010969 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 592316010970 TPP-binding site [chemical binding]; other site 592316010971 dimer interface [polypeptide binding]; other site 592316010972 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 592316010973 PYR/PP interface [polypeptide binding]; other site 592316010974 dimer interface [polypeptide binding]; other site 592316010975 TPP binding site [chemical binding]; other site 592316010976 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 592316010977 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 592316010978 active site 592316010979 phosphorylation site [posttranslational modification] 592316010980 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 592316010981 active site 592316010982 P-loop; other site 592316010983 phosphorylation site [posttranslational modification] 592316010984 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 592316010985 hypothetical protein; Provisional; Region: PRK10626 592316010986 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 592316010987 hypothetical protein; Provisional; Region: PRK11702 592316010988 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 592316010989 adenine DNA glycosylase; Provisional; Region: PRK10880 592316010990 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 592316010991 minor groove reading motif; other site 592316010992 helix-hairpin-helix signature motif; other site 592316010993 substrate binding pocket [chemical binding]; other site 592316010994 active site 592316010995 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 592316010996 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 592316010997 DNA binding and oxoG recognition site [nucleotide binding] 592316010998 oxidative damage protection protein; Provisional; Region: PRK05408 592316010999 murein transglycosylase C; Provisional; Region: mltC; PRK11671 592316011000 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 592316011001 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 592316011002 N-acetyl-D-glucosamine binding site [chemical binding]; other site 592316011003 catalytic residue [active] 592316011004 ornithine decarboxylase; Provisional; Region: PRK13578 592316011005 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 592316011006 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 592316011007 homodimer interface [polypeptide binding]; other site 592316011008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316011009 catalytic residue [active] 592316011010 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 592316011011 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 592316011012 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 592316011013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316011014 NAD(P) binding site [chemical binding]; other site 592316011015 active site 592316011016 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 592316011017 Transcriptional regulator [Transcription]; Region: IclR; COG1414 592316011018 Bacterial transcriptional regulator; Region: IclR; pfam01614 592316011019 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316011020 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316011021 substrate binding pocket [chemical binding]; other site 592316011022 membrane-bound complex binding site; other site 592316011023 hinge residues; other site 592316011024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316011025 dimer interface [polypeptide binding]; other site 592316011026 conserved gate region; other site 592316011027 putative PBP binding loops; other site 592316011028 ABC-ATPase subunit interface; other site 592316011029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316011030 dimer interface [polypeptide binding]; other site 592316011031 conserved gate region; other site 592316011032 putative PBP binding loops; other site 592316011033 ABC-ATPase subunit interface; other site 592316011034 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316011035 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316011036 Walker A/P-loop; other site 592316011037 ATP binding site [chemical binding]; other site 592316011038 Q-loop/lid; other site 592316011039 ABC transporter signature motif; other site 592316011040 Walker B; other site 592316011041 D-loop; other site 592316011042 H-loop/switch region; other site 592316011043 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 592316011044 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 592316011045 hypothetical protein; Provisional; Region: PRK09956 592316011046 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 592316011047 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 592316011048 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 592316011049 NADP binding site [chemical binding]; other site 592316011050 dimer interface [polypeptide binding]; other site 592316011051 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 592316011052 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 592316011053 Walker A/P-loop; other site 592316011054 ATP binding site [chemical binding]; other site 592316011055 Q-loop/lid; other site 592316011056 ABC transporter signature motif; other site 592316011057 Walker B; other site 592316011058 D-loop; other site 592316011059 H-loop/switch region; other site 592316011060 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 592316011061 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592316011062 dimer interface [polypeptide binding]; other site 592316011063 putative PBP binding regions; other site 592316011064 ABC-ATPase subunit interface; other site 592316011065 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 592316011066 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 592316011067 putative hemin binding site; other site 592316011068 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 592316011069 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 592316011070 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 592316011071 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 592316011072 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316011073 N-terminal plug; other site 592316011074 ligand-binding site [chemical binding]; other site 592316011075 Rdx family; Region: Rdx; cl01407 592316011076 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316011077 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316011078 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592316011079 dimerization interface [polypeptide binding]; other site 592316011080 Protein of unknown function (DUF554); Region: DUF554; pfam04474 592316011081 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 592316011082 Flavoprotein; Region: Flavoprotein; pfam02441 592316011083 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 592316011084 Predicted transcriptional regulators [Transcription]; Region: COG1695 592316011085 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 592316011086 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 592316011087 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 592316011088 FAD binding pocket [chemical binding]; other site 592316011089 FAD binding motif [chemical binding]; other site 592316011090 phosphate binding motif [ion binding]; other site 592316011091 NAD binding pocket [chemical binding]; other site 592316011092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316011093 short chain dehydrogenase; Provisional; Region: PRK07041 592316011094 NAD(P) binding site [chemical binding]; other site 592316011095 active site 592316011096 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 592316011097 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 592316011098 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 592316011099 metal binding site [ion binding]; metal-binding site 592316011100 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 592316011101 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 592316011102 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 592316011103 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592316011104 ABC-ATPase subunit interface; other site 592316011105 dimer interface [polypeptide binding]; other site 592316011106 putative PBP binding regions; other site 592316011107 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 592316011108 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592316011109 ABC-ATPase subunit interface; other site 592316011110 dimer interface [polypeptide binding]; other site 592316011111 putative PBP binding regions; other site 592316011112 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 592316011113 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316011114 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 592316011115 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 592316011116 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 592316011117 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 592316011118 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 592316011119 Predicted transcriptional regulators [Transcription]; Region: COG1733 592316011120 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 592316011121 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 592316011122 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 592316011123 NADP binding site [chemical binding]; other site 592316011124 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316011125 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316011126 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592316011127 dimerization interface [polypeptide binding]; other site 592316011128 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592316011129 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 592316011130 active site 592316011131 metal binding site [ion binding]; metal-binding site 592316011132 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 592316011133 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 592316011134 putative NAD(P) binding site [chemical binding]; other site 592316011135 substrate binding site [chemical binding]; other site 592316011136 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 592316011137 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 592316011138 active site 592316011139 FMN binding site [chemical binding]; other site 592316011140 substrate binding site [chemical binding]; other site 592316011141 homotetramer interface [polypeptide binding]; other site 592316011142 catalytic residue [active] 592316011143 trehalase; Provisional; Region: treF; PRK13270 592316011144 Trehalase; Region: Trehalase; pfam01204 592316011145 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 592316011146 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 592316011147 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592316011148 Transmembrane secretion effector; Region: MFS_3; pfam05977 592316011149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316011150 putative substrate translocation pore; other site 592316011151 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316011152 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316011153 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316011154 dimerization interface [polypeptide binding]; other site 592316011155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 592316011156 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 592316011157 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 592316011158 active site 592316011159 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592316011160 putative active site [active] 592316011161 PAS fold; Region: PAS_3; pfam08447 592316011162 heme pocket [chemical binding]; other site 592316011163 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592316011164 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316011165 metal binding site [ion binding]; metal-binding site 592316011166 active site 592316011167 I-site; other site 592316011168 mannonate dehydratase; Provisional; Region: PRK03906 592316011169 mannonate dehydratase; Region: uxuA; TIGR00695 592316011170 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 592316011171 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 592316011172 putative active site [active] 592316011173 metal binding site [ion binding]; metal-binding site 592316011174 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 592316011175 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 592316011176 putative ligand binding site [chemical binding]; other site 592316011177 Uncharacterized conserved protein [Function unknown]; Region: COG5276 592316011178 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316011179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316011180 dimer interface [polypeptide binding]; other site 592316011181 conserved gate region; other site 592316011182 putative PBP binding loops; other site 592316011183 ABC-ATPase subunit interface; other site 592316011184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316011185 dimer interface [polypeptide binding]; other site 592316011186 conserved gate region; other site 592316011187 putative PBP binding loops; other site 592316011188 ABC-ATPase subunit interface; other site 592316011189 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316011190 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316011191 substrate binding pocket [chemical binding]; other site 592316011192 membrane-bound complex binding site; other site 592316011193 hinge residues; other site 592316011194 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316011195 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316011196 Walker A/P-loop; other site 592316011197 ATP binding site [chemical binding]; other site 592316011198 Q-loop/lid; other site 592316011199 ABC transporter signature motif; other site 592316011200 Walker B; other site 592316011201 D-loop; other site 592316011202 H-loop/switch region; other site 592316011203 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 592316011204 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 592316011205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 592316011206 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 592316011207 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592316011208 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316011209 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316011210 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316011211 dimerization interface [polypeptide binding]; other site 592316011212 putative outer membrane lipoprotein; Provisional; Region: PRK09967 592316011213 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592316011214 ligand binding site [chemical binding]; other site 592316011215 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 592316011216 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316011217 metal binding site [ion binding]; metal-binding site 592316011218 active site 592316011219 I-site; other site 592316011220 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 592316011221 Proline dehydrogenase; Region: Pro_dh; cl03282 592316011222 Peptidase M60-like family; Region: M60-like; pfam13402 592316011223 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 592316011224 aromatic chitin/cellulose binding site residues [chemical binding]; other site 592316011225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 592316011226 Chitin binding domain; Region: Chitin_bind_3; pfam03067 592316011227 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 592316011228 Autoinducer binding domain; Region: Autoind_bind; pfam03472 592316011229 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592316011230 DNA binding residues [nucleotide binding] 592316011231 dimerization interface [polypeptide binding]; other site 592316011232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 592316011233 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 592316011234 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 592316011235 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 592316011236 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592316011237 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316011238 non-specific DNA binding site [nucleotide binding]; other site 592316011239 salt bridge; other site 592316011240 sequence-specific DNA binding site [nucleotide binding]; other site 592316011241 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 592316011242 DNA methylase; Region: N6_N4_Mtase; pfam01555 592316011243 DNA methylase; Region: N6_N4_Mtase; pfam01555 592316011244 Restriction endonuclease NotI; Region: NotI; pfam12183 592316011245 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592316011246 PAS domain; Region: PAS_9; pfam13426 592316011247 putative active site [active] 592316011248 heme pocket [chemical binding]; other site 592316011249 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592316011250 PAS domain; Region: PAS_9; pfam13426 592316011251 putative active site [active] 592316011252 heme pocket [chemical binding]; other site 592316011253 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592316011254 dimer interface [polypeptide binding]; other site 592316011255 putative CheW interface [polypeptide binding]; other site 592316011256 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 592316011257 FOG: CBS domain [General function prediction only]; Region: COG0517 592316011258 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 592316011259 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 592316011260 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592316011261 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316011262 metal binding site [ion binding]; metal-binding site 592316011263 active site 592316011264 I-site; other site 592316011265 penicillin-binding protein 2; Provisional; Region: PRK10795 592316011266 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 592316011267 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 592316011268 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 592316011269 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 592316011270 phosphopentomutase; Provisional; Region: PRK05362 592316011271 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 592316011272 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 592316011273 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 592316011274 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 592316011275 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 592316011276 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 592316011277 intersubunit interface [polypeptide binding]; other site 592316011278 active site 592316011279 catalytic residue [active] 592316011280 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 592316011281 active site 592316011282 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 592316011283 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 592316011284 active site 592316011285 nucleophile elbow; other site 592316011286 periplasmic protein; Provisional; Region: PRK10568 592316011287 BON domain; Region: BON; pfam04972 592316011288 BON domain; Region: BON; pfam04972 592316011289 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 592316011290 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 592316011291 G1 box; other site 592316011292 putative GEF interaction site [polypeptide binding]; other site 592316011293 GTP/Mg2+ binding site [chemical binding]; other site 592316011294 Switch I region; other site 592316011295 G2 box; other site 592316011296 G3 box; other site 592316011297 Switch II region; other site 592316011298 G4 box; other site 592316011299 G5 box; other site 592316011300 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 592316011301 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 592316011302 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 592316011303 metal binding site [ion binding]; metal-binding site 592316011304 putative dimer interface [polypeptide binding]; other site 592316011305 hypothetical protein; Provisional; Region: PRK10519 592316011306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 592316011307 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 592316011308 Ferritin-like domain; Region: Ferritin; pfam00210 592316011309 ferroxidase diiron center [ion binding]; other site 592316011310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592316011311 PAS domain; Region: PAS_9; pfam13426 592316011312 putative active site [active] 592316011313 heme pocket [chemical binding]; other site 592316011314 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592316011315 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 592316011316 putative active site [active] 592316011317 heme pocket [chemical binding]; other site 592316011318 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592316011319 putative active site [active] 592316011320 heme pocket [chemical binding]; other site 592316011321 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316011322 metal binding site [ion binding]; metal-binding site 592316011323 active site 592316011324 I-site; other site 592316011325 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592316011326 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 592316011327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316011328 putative PBP binding loops; other site 592316011329 dimer interface [polypeptide binding]; other site 592316011330 ABC-ATPase subunit interface; other site 592316011331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316011332 dimer interface [polypeptide binding]; other site 592316011333 conserved gate region; other site 592316011334 putative PBP binding loops; other site 592316011335 ABC-ATPase subunit interface; other site 592316011336 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 592316011337 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 592316011338 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 592316011339 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316011340 Walker A/P-loop; other site 592316011341 ATP binding site [chemical binding]; other site 592316011342 Q-loop/lid; other site 592316011343 ABC transporter signature motif; other site 592316011344 Walker B; other site 592316011345 D-loop; other site 592316011346 H-loop/switch region; other site 592316011347 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 592316011348 putative acyl-acceptor binding pocket; other site 592316011349 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 592316011350 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 592316011351 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 592316011352 active site 592316011353 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 592316011354 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 592316011355 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 592316011356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 592316011357 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 592316011358 Uncharacterized conserved protein [Function unknown]; Region: COG2308 592316011359 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 592316011360 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 592316011361 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 592316011362 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316011363 DNA-binding site [nucleotide binding]; DNA binding site 592316011364 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316011365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316011366 homodimer interface [polypeptide binding]; other site 592316011367 catalytic residue [active] 592316011368 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 592316011369 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 592316011370 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 592316011371 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592316011372 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316011373 metal binding site [ion binding]; metal-binding site 592316011374 active site 592316011375 I-site; other site 592316011376 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592316011377 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 592316011378 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 592316011379 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 592316011380 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592316011381 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316011382 metal binding site [ion binding]; metal-binding site 592316011383 active site 592316011384 I-site; other site 592316011385 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592316011386 Spore Coat Protein U domain; Region: SCPU; cl02253 592316011387 Spore Coat Protein U domain; Region: SCPU; pfam05229 592316011388 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 592316011389 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 592316011390 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 592316011391 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 592316011392 PapC C-terminal domain; Region: PapC_C; pfam13953 592316011393 Spore Coat Protein U domain; Region: SCPU; pfam05229 592316011394 citrate-proton symporter; Provisional; Region: PRK15075 592316011395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316011396 putative substrate translocation pore; other site 592316011397 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 592316011398 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 592316011399 biopolymer transport protein ExbB; Provisional; Region: PRK10414 592316011400 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 592316011401 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 592316011402 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 592316011403 DctM-like transporters; Region: DctM; pfam06808 592316011404 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 592316011405 cystathionine beta-lyase; Provisional; Region: PRK08114 592316011406 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 592316011407 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592316011408 catalytic residue [active] 592316011409 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 592316011410 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 592316011411 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 592316011412 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 592316011413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316011414 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316011415 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592316011416 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592316011417 active site 592316011418 catalytic tetrad [active] 592316011419 FtsI repressor; Provisional; Region: PRK10883 592316011420 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 592316011421 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 592316011422 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 592316011423 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 592316011424 putative acyl-acceptor binding pocket; other site 592316011425 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 592316011426 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 592316011427 CAP-like domain; other site 592316011428 active site 592316011429 primary dimer interface [polypeptide binding]; other site 592316011430 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 592316011431 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 592316011432 Mga helix-turn-helix domain; Region: Mga; pfam05043 592316011433 PRD domain; Region: PRD; pfam00874 592316011434 PRD domain; Region: PRD; pfam00874 592316011435 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 592316011436 active site 592316011437 P-loop; other site 592316011438 phosphorylation site [posttranslational modification] 592316011439 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 592316011440 active site 592316011441 phosphorylation site [posttranslational modification] 592316011442 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 592316011443 active site 592316011444 P-loop; other site 592316011445 phosphorylation site [posttranslational modification] 592316011446 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 592316011447 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 592316011448 intersubunit interface [polypeptide binding]; other site 592316011449 active site 592316011450 zinc binding site [ion binding]; other site 592316011451 Na+ binding site [ion binding]; other site 592316011452 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 592316011453 intersubunit interface [polypeptide binding]; other site 592316011454 active site 592316011455 zinc binding site [ion binding]; other site 592316011456 Na+ binding site [ion binding]; other site 592316011457 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316011458 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316011459 substrate binding pocket [chemical binding]; other site 592316011460 membrane-bound complex binding site; other site 592316011461 hinge residues; other site 592316011462 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 592316011463 Uncharacterized conserved protein [Function unknown]; Region: COG1359 592316011464 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316011465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316011466 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316011467 dimerization interface [polypeptide binding]; other site 592316011468 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 592316011469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316011470 ATP binding site [chemical binding]; other site 592316011471 Mg2+ binding site [ion binding]; other site 592316011472 G-X-G motif; other site 592316011473 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 592316011474 anchoring element; other site 592316011475 dimer interface [polypeptide binding]; other site 592316011476 ATP binding site [chemical binding]; other site 592316011477 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 592316011478 active site 592316011479 metal binding site [ion binding]; metal-binding site 592316011480 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 592316011481 esterase YqiA; Provisional; Region: PRK11071 592316011482 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 592316011483 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 592316011484 active site 592316011485 metal binding site [ion binding]; metal-binding site 592316011486 hexamer interface [polypeptide binding]; other site 592316011487 putative dehydrogenase; Provisional; Region: PRK11039 592316011488 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 592316011489 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 592316011490 dimer interface [polypeptide binding]; other site 592316011491 ADP-ribose binding site [chemical binding]; other site 592316011492 active site 592316011493 nudix motif; other site 592316011494 metal binding site [ion binding]; metal-binding site 592316011495 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 592316011496 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 592316011497 hypothetical protein; Provisional; Region: PRK11653 592316011498 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 592316011499 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 592316011500 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 592316011501 putative active site [active] 592316011502 metal binding site [ion binding]; metal-binding site 592316011503 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 592316011504 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 592316011505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 592316011506 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 592316011507 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 592316011508 putative ribose interaction site [chemical binding]; other site 592316011509 putative ADP binding site [chemical binding]; other site 592316011510 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 592316011511 active site 592316011512 nucleotide binding site [chemical binding]; other site 592316011513 HIGH motif; other site 592316011514 KMSKS motif; other site 592316011515 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 592316011516 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 592316011517 metal binding triad; other site 592316011518 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 592316011519 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 592316011520 metal binding triad; other site 592316011521 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 592316011522 Uncharacterized conserved protein [Function unknown]; Region: COG3025 592316011523 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 592316011524 putative active site [active] 592316011525 putative metal binding residues [ion binding]; other site 592316011526 signature motif; other site 592316011527 putative triphosphate binding site [ion binding]; other site 592316011528 SH3 domain-containing protein; Provisional; Region: PRK10884 592316011529 Bacterial SH3 domain homologues; Region: SH3b; smart00287 592316011530 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 592316011531 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 592316011532 active site 592316011533 NTP binding site [chemical binding]; other site 592316011534 metal binding triad [ion binding]; metal-binding site 592316011535 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 592316011536 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592316011537 Zn2+ binding site [ion binding]; other site 592316011538 Mg2+ binding site [ion binding]; other site 592316011539 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 592316011540 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 592316011541 homooctamer interface [polypeptide binding]; other site 592316011542 active site 592316011543 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 592316011544 UGMP family protein; Validated; Region: PRK09604 592316011545 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 592316011546 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 592316011547 DNA primase; Validated; Region: dnaG; PRK05667 592316011548 CHC2 zinc finger; Region: zf-CHC2; pfam01807 592316011549 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 592316011550 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 592316011551 active site 592316011552 metal binding site [ion binding]; metal-binding site 592316011553 interdomain interaction site; other site 592316011554 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 592316011555 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 592316011556 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 592316011557 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 592316011558 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 592316011559 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 592316011560 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592316011561 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 592316011562 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592316011563 DNA binding residues [nucleotide binding] 592316011564 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 592316011565 active site 592316011566 SUMO-1 interface [polypeptide binding]; other site 592316011567 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592316011568 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316011569 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 592316011570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316011571 NAD(P) binding site [chemical binding]; other site 592316011572 active site 592316011573 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 592316011574 Dimer interface [polypeptide binding]; other site 592316011575 YcaO-like family; Region: YcaO; pfam02624 592316011576 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 592316011577 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 592316011578 tail protein; Provisional; Region: D; PHA02561 592316011579 Phage protein U [General function prediction only]; Region: COG3499 592316011580 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 592316011581 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 592316011582 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 592316011583 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 592316011584 major tail tube protein; Provisional; Region: FII; PHA02600 592316011585 major tail sheath protein; Provisional; Region: FI; PHA02560 592316011586 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 592316011587 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 592316011588 Baseplate J-like protein; Region: Baseplate_J; cl01294 592316011589 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 592316011590 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 592316011591 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 592316011592 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 592316011593 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 592316011594 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 592316011595 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 592316011596 catalytic residues [active] 592316011597 Phage Tail Protein X; Region: Phage_tail_X; cl02088 592316011598 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 592316011599 terminase endonuclease subunit; Provisional; Region: M; PHA02537 592316011600 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 592316011601 capsid protein; Provisional; Region: N; PHA02538 592316011602 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 592316011603 terminase ATPase subunit; Provisional; Region: P; PHA02535 592316011604 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 592316011605 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 592316011606 portal vertex protein; Provisional; Region: Q; PHA02536 592316011607 Phage portal protein; Region: Phage_portal; pfam04860 592316011608 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 592316011609 HNH endonuclease; Region: HNH_2; pfam13391 592316011610 Uncharacterized conserved protein [Function unknown]; Region: COG4933 592316011611 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 592316011612 DksA-like zinc finger domain containing protein; Region: PHA00080 592316011613 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 592316011614 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 592316011615 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 592316011616 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 592316011617 Catalytic site [active] 592316011618 integrase; Provisional; Region: int; PHA02601 592316011619 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 592316011620 dimer interface [polypeptide binding]; other site 592316011621 active site 592316011622 catalytic residues [active] 592316011623 Int/Topo IB signature motif; other site 592316011624 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 592316011625 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 592316011626 ImpA domain protein; Region: DUF3702; pfam12486 592316011627 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 592316011628 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 592316011629 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 592316011630 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 592316011631 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 592316011632 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 592316011633 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 592316011634 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 592316011635 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 592316011636 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 592316011637 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 592316011638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316011639 Walker A motif; other site 592316011640 ATP binding site [chemical binding]; other site 592316011641 Walker B motif; other site 592316011642 arginine finger; other site 592316011643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316011644 Walker A motif; other site 592316011645 ATP binding site [chemical binding]; other site 592316011646 Walker B motif; other site 592316011647 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 592316011648 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 592316011649 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 592316011650 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 592316011651 ligand binding site [chemical binding]; other site 592316011652 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 592316011653 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 592316011654 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 592316011655 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 592316011656 Protein of unknown function (DUF877); Region: DUF877; pfam05943 592316011657 Protein of unknown function (DUF770); Region: DUF770; pfam05591 592316011658 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 592316011659 FOG: Zn-finger [General function prediction only]; Region: COG5048 592316011660 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 592316011661 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 592316011662 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 592316011663 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592316011664 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316011665 metal binding site [ion binding]; metal-binding site 592316011666 active site 592316011667 I-site; other site 592316011668 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 592316011669 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 592316011670 Sulfate transporter family; Region: Sulfate_transp; pfam00916 592316011671 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 592316011672 active site clefts [active] 592316011673 zinc binding site [ion binding]; other site 592316011674 dimer interface [polypeptide binding]; other site 592316011675 Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503 592316011676 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 592316011677 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 592316011678 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316011679 DNA binding site [nucleotide binding] 592316011680 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 592316011681 putative dimerization interface [polypeptide binding]; other site 592316011682 putative ligand binding site [chemical binding]; other site 592316011683 fructuronate transporter; Provisional; Region: PRK10034; cl15264 592316011684 gluconate transporter; Region: gntP; TIGR00791 592316011685 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 592316011686 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 592316011687 NADP binding site [chemical binding]; other site 592316011688 homodimer interface [polypeptide binding]; other site 592316011689 active site 592316011690 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 592316011691 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 592316011692 putative NAD(P) binding site [chemical binding]; other site 592316011693 catalytic Zn binding site [ion binding]; other site 592316011694 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 592316011695 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 592316011696 active site 592316011697 FMN binding site [chemical binding]; other site 592316011698 2,4-decadienoyl-CoA binding site; other site 592316011699 catalytic residue [active] 592316011700 4Fe-4S cluster binding site [ion binding]; other site 592316011701 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 592316011702 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592316011703 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 592316011704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316011705 S-adenosylmethionine binding site [chemical binding]; other site 592316011706 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 592316011707 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316011708 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316011709 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592316011710 dimerization interface [polypeptide binding]; other site 592316011711 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 592316011712 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592316011713 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 592316011714 classical (c) SDRs; Region: SDR_c; cd05233 592316011715 NAD(P) binding site [chemical binding]; other site 592316011716 active site 592316011717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316011718 metabolite-proton symporter; Region: 2A0106; TIGR00883 592316011719 putative substrate translocation pore; other site 592316011720 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 592316011721 homotrimer interaction site [polypeptide binding]; other site 592316011722 putative active site [active] 592316011723 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 592316011724 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 592316011725 Cl- selectivity filter; other site 592316011726 Cl- binding residues [ion binding]; other site 592316011727 pore gating glutamate residue; other site 592316011728 dimer interface [polypeptide binding]; other site 592316011729 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 592316011730 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592316011731 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592316011732 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 592316011733 serine/threonine transporter SstT; Provisional; Region: PRK13628 592316011734 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 592316011735 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 592316011736 galactarate dehydratase; Region: galactar-dH20; TIGR03248 592316011737 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 592316011738 altronate oxidoreductase; Provisional; Region: PRK03643 592316011739 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 592316011740 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 592316011741 Glucuronate isomerase; Region: UxaC; pfam02614 592316011742 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 592316011743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316011744 D-galactonate transporter; Region: 2A0114; TIGR00893 592316011745 putative substrate translocation pore; other site 592316011746 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 592316011747 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316011748 DNA-binding site [nucleotide binding]; DNA binding site 592316011749 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 592316011750 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 592316011751 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 592316011752 SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136 592316011753 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 592316011754 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 592316011755 Predicted membrane protein [Function unknown]; Region: COG5393 592316011756 YqjK-like protein; Region: YqjK; pfam13997 592316011757 Predicted membrane protein [Function unknown]; Region: COG2259 592316011758 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 592316011759 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 592316011760 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 592316011761 putative dimer interface [polypeptide binding]; other site 592316011762 N-terminal domain interface [polypeptide binding]; other site 592316011763 putative substrate binding pocket (H-site) [chemical binding]; other site 592316011764 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 592316011765 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 592316011766 putative SAM binding site [chemical binding]; other site 592316011767 putative homodimer interface [polypeptide binding]; other site 592316011768 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 592316011769 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 592316011770 putative ligand binding site [chemical binding]; other site 592316011771 hypothetical protein; Reviewed; Region: PRK12497 592316011772 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 592316011773 dimer interface [polypeptide binding]; other site 592316011774 active site 592316011775 outer membrane lipoprotein; Provisional; Region: PRK11023 592316011776 BON domain; Region: BON; pfam04972 592316011777 BON domain; Region: BON; pfam04972 592316011778 Pirin-related protein [General function prediction only]; Region: COG1741 592316011779 Pirin; Region: Pirin; pfam02678 592316011780 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316011781 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 592316011782 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316011783 dimerization interface [polypeptide binding]; other site 592316011784 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 592316011785 Mga helix-turn-helix domain; Region: Mga; pfam05043 592316011786 PRD domain; Region: PRD; pfam00874 592316011787 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 592316011788 active site 592316011789 P-loop; other site 592316011790 phosphorylation site [posttranslational modification] 592316011791 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 592316011792 active site 592316011793 phosphorylation site [posttranslational modification] 592316011794 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 592316011795 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 592316011796 catalytic residue [active] 592316011797 dihydroorotase; Provisional; Region: PRK09237 592316011798 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 592316011799 active site 592316011800 Domain of unknown function (DUF4310); Region: DUF4310; pfam14187 592316011801 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 592316011802 Domain of unknown function (DUF4312); Region: DUF4312; pfam14189 592316011803 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 592316011804 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 592316011805 Cytochrome b562; Region: Cytochrom_B562; cl01546 592316011806 peptidase PmbA; Provisional; Region: PRK11040 592316011807 hypothetical protein; Provisional; Region: PRK05255 592316011808 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 592316011809 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 592316011810 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 592316011811 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 592316011812 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 592316011813 AMP binding site [chemical binding]; other site 592316011814 metal binding site [ion binding]; metal-binding site 592316011815 active site 592316011816 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 592316011817 dimerization interface [polypeptide binding]; other site 592316011818 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 592316011819 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592316011820 dimer interface [polypeptide binding]; other site 592316011821 putative CheW interface [polypeptide binding]; other site 592316011822 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 592316011823 Predicted membrane protein [Function unknown]; Region: COG2707 592316011824 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 592316011825 dimer interface [polypeptide binding]; other site 592316011826 substrate binding site [chemical binding]; other site 592316011827 metal binding sites [ion binding]; metal-binding site 592316011828 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 592316011829 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 592316011830 putative active site pocket [active] 592316011831 dimerization interface [polypeptide binding]; other site 592316011832 putative catalytic residue [active] 592316011833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 592316011834 Family of unknown function (DUF490); Region: DUF490; pfam04357 592316011835 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 592316011836 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 592316011837 Surface antigen; Region: Bac_surface_Ag; pfam01103 592316011838 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 592316011839 Domain of unknown function DUF21; Region: DUF21; pfam01595 592316011840 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 592316011841 Transporter associated domain; Region: CorC_HlyC; smart01091 592316011842 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 592316011843 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 592316011844 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 592316011845 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 592316011846 active site 592316011847 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 592316011848 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 592316011849 active site 592316011850 metal binding site [ion binding]; metal-binding site 592316011851 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 592316011852 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 592316011853 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 592316011854 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 592316011855 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 592316011856 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 592316011857 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 592316011858 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 592316011859 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 592316011860 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 592316011861 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 592316011862 dimer interface [polypeptide binding]; other site 592316011863 ssDNA binding site [nucleotide binding]; other site 592316011864 tetramer (dimer of dimers) interface [polypeptide binding]; other site 592316011865 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 592316011866 esterase; Provisional; Region: PRK10566 592316011867 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592316011868 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592316011869 dimerization interface [polypeptide binding]; other site 592316011870 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 592316011871 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592316011872 dimer interface [polypeptide binding]; other site 592316011873 putative CheW interface [polypeptide binding]; other site 592316011874 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 592316011875 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 592316011876 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 592316011877 FAD binding site [chemical binding]; other site 592316011878 substrate binding site [chemical binding]; other site 592316011879 catalytic residues [active] 592316011880 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 592316011881 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 592316011882 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 592316011883 exoribonuclease R; Provisional; Region: PRK11642 592316011884 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 592316011885 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 592316011886 RNB domain; Region: RNB; pfam00773 592316011887 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 592316011888 RNA binding site [nucleotide binding]; other site 592316011889 Predicted transcriptional regulator [Transcription]; Region: COG1959 592316011890 transcriptional repressor NsrR; Provisional; Region: PRK11014 592316011891 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 592316011892 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 592316011893 GDP-binding site [chemical binding]; other site 592316011894 ACT binding site; other site 592316011895 IMP binding site; other site 592316011896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 592316011897 FtsH protease regulator HflC; Provisional; Region: PRK11029 592316011898 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 592316011899 FtsH protease regulator HflK; Provisional; Region: PRK10930 592316011900 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 592316011901 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 592316011902 GTPase HflX; Provisional; Region: PRK11058 592316011903 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 592316011904 HflX GTPase family; Region: HflX; cd01878 592316011905 G1 box; other site 592316011906 GTP/Mg2+ binding site [chemical binding]; other site 592316011907 Switch I region; other site 592316011908 G2 box; other site 592316011909 G3 box; other site 592316011910 Switch II region; other site 592316011911 G4 box; other site 592316011912 G5 box; other site 592316011913 bacterial Hfq-like; Region: Hfq; cd01716 592316011914 hexamer interface [polypeptide binding]; other site 592316011915 Sm1 motif; other site 592316011916 RNA binding site [nucleotide binding]; other site 592316011917 Sm2 motif; other site 592316011918 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 592316011919 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 592316011920 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 592316011921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316011922 ATP binding site [chemical binding]; other site 592316011923 Mg2+ binding site [ion binding]; other site 592316011924 G-X-G motif; other site 592316011925 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 592316011926 ATP binding site [chemical binding]; other site 592316011927 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 592316011928 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 592316011929 AMIN domain; Region: AMIN; pfam11741 592316011930 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 592316011931 active site 592316011932 metal binding site [ion binding]; metal-binding site 592316011933 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592316011934 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 592316011935 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 592316011936 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 592316011937 putative carbohydrate kinase; Provisional; Region: PRK10565 592316011938 Uncharacterized conserved protein [Function unknown]; Region: COG0062 592316011939 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 592316011940 putative substrate binding site [chemical binding]; other site 592316011941 putative ATP binding site [chemical binding]; other site 592316011942 epoxyqueuosine reductase; Region: TIGR00276 592316011943 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 592316011944 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 592316011945 catalytic site [active] 592316011946 putative active site [active] 592316011947 putative substrate binding site [chemical binding]; other site 592316011948 dimer interface [polypeptide binding]; other site 592316011949 GTPase RsgA; Reviewed; Region: PRK12288 592316011950 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 592316011951 RNA binding site [nucleotide binding]; other site 592316011952 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 592316011953 GTPase/Zn-binding domain interface [polypeptide binding]; other site 592316011954 GTP/Mg2+ binding site [chemical binding]; other site 592316011955 G4 box; other site 592316011956 G5 box; other site 592316011957 G1 box; other site 592316011958 Switch I region; other site 592316011959 G2 box; other site 592316011960 G3 box; other site 592316011961 Switch II region; other site 592316011962 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 592316011963 putative mechanosensitive channel protein; Provisional; Region: PRK10929 592316011964 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 592316011965 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592316011966 malate dehydrogenase; Provisional; Region: PRK05086 592316011967 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 592316011968 NAD binding site [chemical binding]; other site 592316011969 dimerization interface [polypeptide binding]; other site 592316011970 Substrate binding site [chemical binding]; other site 592316011971 arginine repressor; Provisional; Region: PRK05066 592316011972 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 592316011973 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 592316011974 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 592316011975 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 592316011976 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 592316011977 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 592316011978 RNAase interaction site [polypeptide binding]; other site 592316011979 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 592316011980 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 592316011981 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 592316011982 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592316011983 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316011984 efflux system membrane protein; Provisional; Region: PRK11594 592316011985 transcriptional regulator; Provisional; Region: PRK10632 592316011986 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316011987 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 592316011988 putative effector binding pocket; other site 592316011989 dimerization interface [polypeptide binding]; other site 592316011990 protease TldD; Provisional; Region: tldD; PRK10735 592316011991 hypothetical protein; Provisional; Region: PRK10899 592316011992 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 592316011993 ribonuclease G; Provisional; Region: PRK11712 592316011994 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 592316011995 homodimer interface [polypeptide binding]; other site 592316011996 oligonucleotide binding site [chemical binding]; other site 592316011997 Maf-like protein; Region: Maf; pfam02545 592316011998 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 592316011999 active site 592316012000 dimer interface [polypeptide binding]; other site 592316012001 rod shape-determining protein MreD; Provisional; Region: PRK11060 592316012002 rod shape-determining protein MreC; Region: mreC; TIGR00219 592316012003 rod shape-determining protein MreC; Region: MreC; pfam04085 592316012004 rod shape-determining protein MreB; Provisional; Region: PRK13927 592316012005 MreB and similar proteins; Region: MreB_like; cd10225 592316012006 nucleotide binding site [chemical binding]; other site 592316012007 Mg binding site [ion binding]; other site 592316012008 putative protofilament interaction site [polypeptide binding]; other site 592316012009 RodZ interaction site [polypeptide binding]; other site 592316012010 regulatory protein CsrD; Provisional; Region: PRK11059 592316012011 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316012012 metal binding site [ion binding]; metal-binding site 592316012013 active site 592316012014 I-site; other site 592316012015 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592316012016 TMAO/DMSO reductase; Reviewed; Region: PRK05363 592316012017 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 592316012018 Moco binding site; other site 592316012019 metal coordination site [ion binding]; other site 592316012020 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 592316012021 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 592316012022 Dehydroquinase class II; Region: DHquinase_II; pfam01220 592316012023 active site 592316012024 trimer interface [polypeptide binding]; other site 592316012025 dimer interface [polypeptide binding]; other site 592316012026 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 592316012027 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 592316012028 carboxyltransferase (CT) interaction site; other site 592316012029 biotinylation site [posttranslational modification]; other site 592316012030 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 592316012031 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592316012032 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 592316012033 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 592316012034 hypothetical protein; Provisional; Region: PRK10633 592316012035 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 592316012036 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 592316012037 Na binding site [ion binding]; other site 592316012038 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 592316012039 Methyltransferase domain; Region: Methyltransf_18; pfam12847 592316012040 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 592316012041 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 592316012042 FMN binding site [chemical binding]; other site 592316012043 active site 592316012044 catalytic residues [active] 592316012045 substrate binding site [chemical binding]; other site 592316012046 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 592316012047 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 592316012048 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316012049 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 592316012050 substrate binding pocket [chemical binding]; other site 592316012051 membrane-bound complex binding site; other site 592316012052 hinge residues; other site 592316012053 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 592316012054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316012055 conserved gate region; other site 592316012056 Protein of unknown function (DUF1109); Region: DUF1109; cl02071 592316012057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316012058 dimer interface [polypeptide binding]; other site 592316012059 ABC-ATPase subunit interface; other site 592316012060 putative PBP binding loops; other site 592316012061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316012062 dimer interface [polypeptide binding]; other site 592316012063 conserved gate region; other site 592316012064 putative PBP binding loops; other site 592316012065 ABC-ATPase subunit interface; other site 592316012066 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316012067 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316012068 Walker A/P-loop; other site 592316012069 ATP binding site [chemical binding]; other site 592316012070 Q-loop/lid; other site 592316012071 ABC transporter signature motif; other site 592316012072 Walker B; other site 592316012073 D-loop; other site 592316012074 H-loop/switch region; other site 592316012075 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 592316012076 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 592316012077 trimer interface [polypeptide binding]; other site 592316012078 putative metal binding site [ion binding]; other site 592316012079 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 592316012080 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 592316012081 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 592316012082 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 592316012083 shikimate binding site; other site 592316012084 NAD(P) binding site [chemical binding]; other site 592316012085 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 592316012086 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 592316012087 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 592316012088 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 592316012089 hypothetical protein; Validated; Region: PRK03430 592316012090 hypothetical protein; Provisional; Region: PRK10736 592316012091 DNA protecting protein DprA; Region: dprA; TIGR00732 592316012092 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 592316012093 active site 592316012094 catalytic residues [active] 592316012095 metal binding site [ion binding]; metal-binding site 592316012096 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 592316012097 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 592316012098 putative active site [active] 592316012099 substrate binding site [chemical binding]; other site 592316012100 putative cosubstrate binding site; other site 592316012101 catalytic site [active] 592316012102 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 592316012103 substrate binding site [chemical binding]; other site 592316012104 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 592316012105 putative RNA binding site [nucleotide binding]; other site 592316012106 16S rRNA methyltransferase B; Provisional; Region: PRK10901 592316012107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316012108 S-adenosylmethionine binding site [chemical binding]; other site 592316012109 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 592316012110 TrkA-N domain; Region: TrkA_N; pfam02254 592316012111 TrkA-C domain; Region: TrkA_C; pfam02080 592316012112 TrkA-N domain; Region: TrkA_N; pfam02254 592316012113 TrkA-C domain; Region: TrkA_C; pfam02080 592316012114 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 592316012115 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 592316012116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 592316012117 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 592316012118 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 592316012119 DNA binding residues [nucleotide binding] 592316012120 dimer interface [polypeptide binding]; other site 592316012121 metal binding site [ion binding]; metal-binding site 592316012122 hypothetical protein; Provisional; Region: PRK10203 592316012123 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 592316012124 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 592316012125 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 592316012126 alphaNTD homodimer interface [polypeptide binding]; other site 592316012127 alphaNTD - beta interaction site [polypeptide binding]; other site 592316012128 alphaNTD - beta' interaction site [polypeptide binding]; other site 592316012129 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 592316012130 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 592316012131 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 592316012132 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592316012133 RNA binding surface [nucleotide binding]; other site 592316012134 30S ribosomal protein S11; Validated; Region: PRK05309 592316012135 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 592316012136 30S ribosomal protein S13; Region: bact_S13; TIGR03631 592316012137 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 592316012138 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 592316012139 SecY translocase; Region: SecY; pfam00344 592316012140 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 592316012141 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 592316012142 23S rRNA binding site [nucleotide binding]; other site 592316012143 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 592316012144 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 592316012145 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 592316012146 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 592316012147 23S rRNA interface [nucleotide binding]; other site 592316012148 5S rRNA interface [nucleotide binding]; other site 592316012149 L27 interface [polypeptide binding]; other site 592316012150 L5 interface [polypeptide binding]; other site 592316012151 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 592316012152 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 592316012153 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 592316012154 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 592316012155 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 592316012156 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 592316012157 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 592316012158 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 592316012159 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 592316012160 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 592316012161 RNA binding site [nucleotide binding]; other site 592316012162 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 592316012163 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 592316012164 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 592316012165 23S rRNA interface [nucleotide binding]; other site 592316012166 putative translocon interaction site; other site 592316012167 signal recognition particle (SRP54) interaction site; other site 592316012168 L23 interface [polypeptide binding]; other site 592316012169 trigger factor interaction site; other site 592316012170 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 592316012171 23S rRNA interface [nucleotide binding]; other site 592316012172 5S rRNA interface [nucleotide binding]; other site 592316012173 putative antibiotic binding site [chemical binding]; other site 592316012174 L25 interface [polypeptide binding]; other site 592316012175 L27 interface [polypeptide binding]; other site 592316012176 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 592316012177 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 592316012178 G-X-X-G motif; other site 592316012179 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 592316012180 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 592316012181 protein-rRNA interface [nucleotide binding]; other site 592316012182 putative translocon binding site; other site 592316012183 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 592316012184 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 592316012185 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 592316012186 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 592316012187 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 592316012188 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 592316012189 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 592316012190 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 592316012191 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 592316012192 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 592316012193 heme binding site [chemical binding]; other site 592316012194 ferroxidase pore; other site 592316012195 ferroxidase diiron center [ion binding]; other site 592316012196 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 592316012197 elongation factor Tu; Reviewed; Region: PRK00049 592316012198 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 592316012199 G1 box; other site 592316012200 GEF interaction site [polypeptide binding]; other site 592316012201 GTP/Mg2+ binding site [chemical binding]; other site 592316012202 Switch I region; other site 592316012203 G2 box; other site 592316012204 G3 box; other site 592316012205 Switch II region; other site 592316012206 G4 box; other site 592316012207 G5 box; other site 592316012208 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 592316012209 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 592316012210 Antibiotic Binding Site [chemical binding]; other site 592316012211 elongation factor G; Reviewed; Region: PRK00007 592316012212 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 592316012213 G1 box; other site 592316012214 putative GEF interaction site [polypeptide binding]; other site 592316012215 GTP/Mg2+ binding site [chemical binding]; other site 592316012216 Switch I region; other site 592316012217 G2 box; other site 592316012218 G3 box; other site 592316012219 Switch II region; other site 592316012220 G4 box; other site 592316012221 G5 box; other site 592316012222 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 592316012223 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 592316012224 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 592316012225 30S ribosomal protein S7; Validated; Region: PRK05302 592316012226 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 592316012227 S17 interaction site [polypeptide binding]; other site 592316012228 S8 interaction site; other site 592316012229 16S rRNA interaction site [nucleotide binding]; other site 592316012230 streptomycin interaction site [chemical binding]; other site 592316012231 23S rRNA interaction site [nucleotide binding]; other site 592316012232 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 592316012233 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 592316012234 sulfur relay protein TusC; Validated; Region: PRK00211 592316012235 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 592316012236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 592316012237 YheO-like PAS domain; Region: PAS_6; pfam08348 592316012238 HTH domain; Region: HTH_22; pfam13309 592316012239 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 592316012240 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 592316012241 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 592316012242 phi X174 lysis protein; Provisional; Region: PRK02793 592316012243 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 592316012244 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 592316012245 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 592316012246 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 592316012247 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 592316012248 TrkA-N domain; Region: TrkA_N; pfam02254 592316012249 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 592316012250 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 592316012251 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316012252 Walker A/P-loop; other site 592316012253 ATP binding site [chemical binding]; other site 592316012254 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592316012255 ABC transporter signature motif; other site 592316012256 Walker B; other site 592316012257 D-loop; other site 592316012258 ABC transporter; Region: ABC_tran_2; pfam12848 592316012259 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592316012260 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 592316012261 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 592316012262 active site 592316012263 iron coordination sites [ion binding]; other site 592316012264 substrate binding pocket [chemical binding]; other site 592316012265 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 592316012266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316012267 dimer interface [polypeptide binding]; other site 592316012268 conserved gate region; other site 592316012269 putative PBP binding loops; other site 592316012270 ABC-ATPase subunit interface; other site 592316012271 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 592316012272 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 592316012273 Walker A/P-loop; other site 592316012274 ATP binding site [chemical binding]; other site 592316012275 Q-loop/lid; other site 592316012276 ABC transporter signature motif; other site 592316012277 Walker B; other site 592316012278 D-loop; other site 592316012279 H-loop/switch region; other site 592316012280 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 592316012281 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316012282 substrate binding pocket [chemical binding]; other site 592316012283 membrane-bound complex binding site; other site 592316012284 hinge residues; other site 592316012285 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 592316012286 putative hydrolase; Provisional; Region: PRK10985 592316012287 hypothetical protein; Provisional; Region: PRK04966 592316012288 phosphoribulokinase; Provisional; Region: PRK15453 592316012289 active site 592316012290 hypothetical protein; Provisional; Region: PRK10738 592316012291 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 592316012292 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 592316012293 ligand binding site [chemical binding]; other site 592316012294 flexible hinge region; other site 592316012295 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 592316012296 putative switch regulator; other site 592316012297 non-specific DNA interactions [nucleotide binding]; other site 592316012298 DNA binding site [nucleotide binding] 592316012299 sequence specific DNA binding site [nucleotide binding]; other site 592316012300 putative cAMP binding site [chemical binding]; other site 592316012301 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 592316012302 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 592316012303 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 592316012304 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 592316012305 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592316012306 inhibitor-cofactor binding pocket; inhibition site 592316012307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316012308 catalytic residue [active] 592316012309 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 592316012310 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 592316012311 glutamine binding [chemical binding]; other site 592316012312 catalytic triad [active] 592316012313 Fic/DOC family; Region: Fic; cl00960 592316012314 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 592316012315 hypothetical protein; Provisional; Region: PRK10204 592316012316 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 592316012317 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 592316012318 substrate binding site [chemical binding]; other site 592316012319 putative transporter; Provisional; Region: PRK03699 592316012320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316012321 putative substrate translocation pore; other site 592316012322 cytosine deaminase; Provisional; Region: PRK09230 592316012323 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 592316012324 active site 592316012325 nitrite reductase subunit NirD; Provisional; Region: PRK14989 592316012326 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592316012327 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 592316012328 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 592316012329 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 592316012330 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 592316012331 siroheme synthase; Provisional; Region: cysG; PRK10637 592316012332 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 592316012333 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 592316012334 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 592316012335 active site 592316012336 SAM binding site [chemical binding]; other site 592316012337 homodimer interface [polypeptide binding]; other site 592316012338 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 592316012339 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 592316012340 active site 592316012341 HIGH motif; other site 592316012342 dimer interface [polypeptide binding]; other site 592316012343 KMSKS motif; other site 592316012344 phosphoglycolate phosphatase; Provisional; Region: PRK13222 592316012345 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316012346 motif II; other site 592316012347 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 592316012348 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 592316012349 substrate binding site [chemical binding]; other site 592316012350 hexamer interface [polypeptide binding]; other site 592316012351 metal binding site [ion binding]; metal-binding site 592316012352 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 592316012353 hypothetical protein; Reviewed; Region: PRK11901 592316012354 cell division protein DamX; Validated; Region: PRK10905 592316012355 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 592316012356 active site 592316012357 dimer interface [polypeptide binding]; other site 592316012358 metal binding site [ion binding]; metal-binding site 592316012359 shikimate kinase; Reviewed; Region: aroK; PRK00131 592316012360 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 592316012361 ADP binding site [chemical binding]; other site 592316012362 magnesium binding site [ion binding]; other site 592316012363 putative shikimate binding site; other site 592316012364 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 592316012365 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 592316012366 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 592316012367 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 592316012368 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 592316012369 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 592316012370 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 592316012371 Transglycosylase; Region: Transgly; pfam00912 592316012372 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 592316012373 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 592316012374 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 592316012375 ADP-ribose binding site [chemical binding]; other site 592316012376 dimer interface [polypeptide binding]; other site 592316012377 active site 592316012378 nudix motif; other site 592316012379 metal binding site [ion binding]; metal-binding site 592316012380 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 592316012381 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 592316012382 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316012383 motif II; other site 592316012384 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592316012385 RNA binding surface [nucleotide binding]; other site 592316012386 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 592316012387 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 592316012388 dimerization interface [polypeptide binding]; other site 592316012389 domain crossover interface; other site 592316012390 redox-dependent activation switch; other site 592316012391 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 592316012392 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 592316012393 active site 592316012394 substrate-binding site [chemical binding]; other site 592316012395 metal-binding site [ion binding] 592316012396 ATP binding site [chemical binding]; other site 592316012397 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 592316012398 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592316012399 dimerization interface [polypeptide binding]; other site 592316012400 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316012401 dimer interface [polypeptide binding]; other site 592316012402 phosphorylation site [posttranslational modification] 592316012403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316012404 ATP binding site [chemical binding]; other site 592316012405 G-X-G motif; other site 592316012406 osmolarity response regulator; Provisional; Region: ompR; PRK09468 592316012407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316012408 active site 592316012409 phosphorylation site [posttranslational modification] 592316012410 intermolecular recognition site; other site 592316012411 dimerization interface [polypeptide binding]; other site 592316012412 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592316012413 DNA binding site [nucleotide binding] 592316012414 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 592316012415 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 592316012416 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 592316012417 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 592316012418 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 592316012419 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 592316012420 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 592316012421 RNA binding site [nucleotide binding]; other site 592316012422 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 592316012423 sucrose phosphorylase; Provisional; Region: PRK13840 592316012424 active site 592316012425 homodimer interface [polypeptide binding]; other site 592316012426 catalytic site [active] 592316012427 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 592316012428 carboxylesterase BioH; Provisional; Region: PRK10349 592316012429 DNA utilization protein GntX; Provisional; Region: PRK11595 592316012430 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592316012431 active site 592316012432 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 592316012433 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 592316012434 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 592316012435 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 592316012436 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 592316012437 maltodextrin phosphorylase; Provisional; Region: PRK14985 592316012438 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 592316012439 homodimer interface [polypeptide binding]; other site 592316012440 active site pocket [active] 592316012441 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 592316012442 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 592316012443 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 592316012444 intramembrane serine protease GlpG; Provisional; Region: PRK10907 592316012445 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 592316012446 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 592316012447 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 592316012448 active site residue [active] 592316012449 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 592316012450 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 592316012451 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 592316012452 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592316012453 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592316012454 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592316012455 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 592316012456 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 592316012457 PYR/PP interface [polypeptide binding]; other site 592316012458 dimer interface [polypeptide binding]; other site 592316012459 TPP binding site [chemical binding]; other site 592316012460 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 592316012461 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 592316012462 TPP-binding site; other site 592316012463 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592316012464 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 592316012465 substrate binding site [chemical binding]; other site 592316012466 ATP binding site [chemical binding]; other site 592316012467 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 592316012468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 592316012469 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 592316012470 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 592316012471 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 592316012472 putative active site [active] 592316012473 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 592316012474 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316012475 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316012476 dimerization interface [polypeptide binding]; other site 592316012477 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592316012478 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 592316012479 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316012480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316012481 dimer interface [polypeptide binding]; other site 592316012482 conserved gate region; other site 592316012483 ABC-ATPase subunit interface; other site 592316012484 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 592316012485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316012486 dimer interface [polypeptide binding]; other site 592316012487 conserved gate region; other site 592316012488 putative PBP binding loops; other site 592316012489 ABC-ATPase subunit interface; other site 592316012490 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 592316012491 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316012492 Walker A/P-loop; other site 592316012493 ATP binding site [chemical binding]; other site 592316012494 Q-loop/lid; other site 592316012495 ABC transporter signature motif; other site 592316012496 Walker B; other site 592316012497 D-loop; other site 592316012498 H-loop/switch region; other site 592316012499 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316012500 Walker A/P-loop; other site 592316012501 ATP binding site [chemical binding]; other site 592316012502 Q-loop/lid; other site 592316012503 ABC transporter signature motif; other site 592316012504 Walker B; other site 592316012505 D-loop; other site 592316012506 H-loop/switch region; other site 592316012507 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316012508 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 592316012509 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 592316012510 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 592316012511 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 592316012512 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 592316012513 tetrameric interface [polypeptide binding]; other site 592316012514 NAD binding site [chemical binding]; other site 592316012515 catalytic residues [active] 592316012516 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 592316012517 major facilitator superfamily transporter; Provisional; Region: PRK05122 592316012518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316012519 putative substrate translocation pore; other site 592316012520 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 592316012521 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 592316012522 Walker A/P-loop; other site 592316012523 ATP binding site [chemical binding]; other site 592316012524 Q-loop/lid; other site 592316012525 ABC transporter signature motif; other site 592316012526 Walker B; other site 592316012527 D-loop; other site 592316012528 H-loop/switch region; other site 592316012529 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 592316012530 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 592316012531 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 592316012532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316012533 dimer interface [polypeptide binding]; other site 592316012534 conserved gate region; other site 592316012535 putative PBP binding loops; other site 592316012536 ABC-ATPase subunit interface; other site 592316012537 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 592316012538 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 592316012539 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592316012540 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 592316012541 dimerization interface [polypeptide binding]; other site 592316012542 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 592316012543 NAD binding site [chemical binding]; other site 592316012544 ligand binding site [chemical binding]; other site 592316012545 catalytic site [active] 592316012546 proline/glycine betaine transporter; Provisional; Region: PRK10642 592316012547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316012548 putative substrate translocation pore; other site 592316012549 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 592316012550 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 592316012551 dimer interface [polypeptide binding]; other site 592316012552 active site 592316012553 Schiff base residues; other site 592316012554 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 592316012555 GAF domain; Region: GAF; pfam01590 592316012556 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592316012557 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316012558 metal binding site [ion binding]; metal-binding site 592316012559 active site 592316012560 I-site; other site 592316012561 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 592316012562 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 592316012563 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 592316012564 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 592316012565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316012566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316012567 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 592316012568 High-affinity nickel-transport protein; Region: NicO; cl00964 592316012569 High-affinity nickel-transport protein; Region: NicO; cl00964 592316012570 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 592316012571 putative metal binding site [ion binding]; other site 592316012572 putative homodimer interface [polypeptide binding]; other site 592316012573 putative homotetramer interface [polypeptide binding]; other site 592316012574 putative homodimer-homodimer interface [polypeptide binding]; other site 592316012575 putative allosteric switch controlling residues; other site 592316012576 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 592316012577 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 592316012578 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 592316012579 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 592316012580 homotrimer interaction site [polypeptide binding]; other site 592316012581 putative active site [active] 592316012582 ornithine cyclodeaminase; Validated; Region: PRK06199 592316012583 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 592316012584 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592316012585 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316012586 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 592316012587 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 592316012588 EamA-like transporter family; Region: EamA; pfam00892 592316012589 Protein of unknown function (DUF796); Region: DUF796; pfam05638 592316012590 Protein of unknown function (DUF796); Region: DUF796; pfam05638 592316012591 Predicted flavoproteins [General function prediction only]; Region: COG2081 592316012592 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 592316012593 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 592316012594 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 592316012595 universal stress protein UspB; Provisional; Region: PRK04960 592316012596 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 592316012597 Ligand Binding Site [chemical binding]; other site 592316012598 putative methyltransferase; Provisional; Region: PRK10742 592316012599 oligopeptidase A; Provisional; Region: PRK10911 592316012600 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 592316012601 active site 592316012602 Zn binding site [ion binding]; other site 592316012603 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 592316012604 ribonuclease Z; Region: RNase_Z; TIGR02651 592316012605 glutathione reductase; Validated; Region: PRK06116 592316012606 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592316012607 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592316012608 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 592316012609 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 592316012610 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 592316012611 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 592316012612 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 592316012613 putative NAD(P) binding site [chemical binding]; other site 592316012614 Epoxide hydrolase N terminus; Region: EHN; pfam06441 592316012615 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 592316012616 short chain dehydrogenase; Provisional; Region: PRK06482 592316012617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316012618 NAD(P) binding site [chemical binding]; other site 592316012619 active site 592316012620 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316012621 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316012622 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 592316012623 putative effector binding pocket; other site 592316012624 putative dimerization interface [polypeptide binding]; other site 592316012625 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 592316012626 Isochorismatase family; Region: Isochorismatase; pfam00857 592316012627 catalytic triad [active] 592316012628 dimer interface [polypeptide binding]; other site 592316012629 conserved cis-peptide bond; other site 592316012630 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 592316012631 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 592316012632 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592316012633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316012634 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592316012635 putative substrate translocation pore; other site 592316012636 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316012637 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316012638 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 592316012639 putative effector binding pocket; other site 592316012640 dimerization interface [polypeptide binding]; other site 592316012641 hypothetical protein; Provisional; Region: PRK05208 592316012642 sensor protein KdpD; Provisional; Region: PRK10490 592316012643 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 592316012644 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 592316012645 Ligand Binding Site [chemical binding]; other site 592316012646 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 592316012647 GAF domain; Region: GAF_3; pfam13492 592316012648 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316012649 dimer interface [polypeptide binding]; other site 592316012650 phosphorylation site [posttranslational modification] 592316012651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316012652 ATP binding site [chemical binding]; other site 592316012653 Mg2+ binding site [ion binding]; other site 592316012654 G-X-G motif; other site 592316012655 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 592316012656 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 592316012657 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 592316012658 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 592316012659 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 592316012660 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 592316012661 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592316012662 Zn2+ binding site [ion binding]; other site 592316012663 Mg2+ binding site [ion binding]; other site 592316012664 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 592316012665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316012666 sequence-specific DNA binding site [nucleotide binding]; other site 592316012667 salt bridge; other site 592316012668 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 592316012669 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 592316012670 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 592316012671 putative ligand binding site [chemical binding]; other site 592316012672 NAD binding site [chemical binding]; other site 592316012673 catalytic site [active] 592316012674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316012675 D-galactonate transporter; Region: 2A0114; TIGR00893 592316012676 putative substrate translocation pore; other site 592316012677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316012678 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 592316012679 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 592316012680 putative ligand binding site [chemical binding]; other site 592316012681 putative acetyltransferase YhhY; Provisional; Region: PRK10140 592316012682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316012683 Coenzyme A binding pocket [chemical binding]; other site 592316012684 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 592316012685 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592316012686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316012687 Walker A/P-loop; other site 592316012688 ATP binding site [chemical binding]; other site 592316012689 Q-loop/lid; other site 592316012690 ABC transporter signature motif; other site 592316012691 Walker B; other site 592316012692 D-loop; other site 592316012693 H-loop/switch region; other site 592316012694 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 592316012695 Protein of unknown function, DUF482; Region: DUF482; pfam04339 592316012696 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316012697 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316012698 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 592316012699 putative effector binding pocket; other site 592316012700 dimerization interface [polypeptide binding]; other site 592316012701 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 592316012702 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 592316012703 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 592316012704 putative dimer interface [polypeptide binding]; other site 592316012705 N-terminal domain interface [polypeptide binding]; other site 592316012706 putative substrate binding pocket (H-site) [chemical binding]; other site 592316012707 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 592316012708 putative hydrolase; Provisional; Region: PRK11460 592316012709 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 592316012710 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 592316012711 Metal-binding active site; metal-binding site 592316012712 chromosome condensation membrane protein; Provisional; Region: PRK14196 592316012713 Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Region: URH1; COG1957 592316012714 active site 592316012715 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 592316012716 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 592316012717 putative NAD(P) binding site [chemical binding]; other site 592316012718 catalytic Zn binding site [ion binding]; other site 592316012719 structural Zn binding site [ion binding]; other site 592316012720 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316012721 DNA-binding site [nucleotide binding]; DNA binding site 592316012722 Transcriptional regulators [Transcription]; Region: GntR; COG1802 592316012723 FCD domain; Region: FCD; pfam07729 592316012724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316012725 D-galactonate transporter; Region: 2A0114; TIGR00893 592316012726 putative substrate translocation pore; other site 592316012727 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316012728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316012729 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592316012730 dimerization interface [polypeptide binding]; other site 592316012731 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 592316012732 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 592316012733 active site 592316012734 dimer interface [polypeptide binding]; other site 592316012735 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592316012736 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 592316012737 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316012738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316012739 putative PBP binding loops; other site 592316012740 dimer interface [polypeptide binding]; other site 592316012741 ABC-ATPase subunit interface; other site 592316012742 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 592316012743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316012744 dimer interface [polypeptide binding]; other site 592316012745 conserved gate region; other site 592316012746 putative PBP binding loops; other site 592316012747 ABC-ATPase subunit interface; other site 592316012748 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 592316012749 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316012750 Walker A/P-loop; other site 592316012751 ATP binding site [chemical binding]; other site 592316012752 Q-loop/lid; other site 592316012753 ABC transporter signature motif; other site 592316012754 Walker B; other site 592316012755 D-loop; other site 592316012756 H-loop/switch region; other site 592316012757 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316012758 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 592316012759 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316012760 Walker A/P-loop; other site 592316012761 ATP binding site [chemical binding]; other site 592316012762 Q-loop/lid; other site 592316012763 ABC transporter signature motif; other site 592316012764 Walker B; other site 592316012765 D-loop; other site 592316012766 H-loop/switch region; other site 592316012767 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 592316012768 Beta-lactamase; Region: Beta-lactamase; pfam00144 592316012769 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 592316012770 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 592316012771 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 592316012772 SxDxEG motif; other site 592316012773 active site 592316012774 metal binding site [ion binding]; metal-binding site 592316012775 homopentamer interface [polypeptide binding]; other site 592316012776 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 592316012777 homodimer interface [polypeptide binding]; other site 592316012778 homotetramer interface [polypeptide binding]; other site 592316012779 active site pocket [active] 592316012780 cleavage site 592316012781 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 592316012782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316012783 dimer interface [polypeptide binding]; other site 592316012784 conserved gate region; other site 592316012785 putative PBP binding loops; other site 592316012786 ABC-ATPase subunit interface; other site 592316012787 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 592316012788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316012789 dimer interface [polypeptide binding]; other site 592316012790 conserved gate region; other site 592316012791 putative PBP binding loops; other site 592316012792 ABC-ATPase subunit interface; other site 592316012793 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 592316012794 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 592316012795 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 592316012796 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316012797 Walker A/P-loop; other site 592316012798 ATP binding site [chemical binding]; other site 592316012799 Q-loop/lid; other site 592316012800 ABC transporter signature motif; other site 592316012801 Walker B; other site 592316012802 D-loop; other site 592316012803 H-loop/switch region; other site 592316012804 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 592316012805 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316012806 Walker A/P-loop; other site 592316012807 ATP binding site [chemical binding]; other site 592316012808 Q-loop/lid; other site 592316012809 ABC transporter signature motif; other site 592316012810 Walker B; other site 592316012811 D-loop; other site 592316012812 H-loop/switch region; other site 592316012813 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 592316012814 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 592316012815 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 592316012816 active site 592316012817 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 592316012818 hypothetical protein; Provisional; Region: PRK11469 592316012819 Domain of unknown function DUF; Region: DUF204; pfam02659 592316012820 Domain of unknown function DUF; Region: DUF204; pfam02659 592316012821 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 592316012822 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 592316012823 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592316012824 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 592316012825 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316012826 DNA-binding site [nucleotide binding]; DNA binding site 592316012827 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316012828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316012829 homodimer interface [polypeptide binding]; other site 592316012830 catalytic residue [active] 592316012831 Uncharacterized conserved protein [Function unknown]; Region: COG2128 592316012832 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 592316012833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 592316012834 malate:quinone oxidoreductase; Validated; Region: PRK05257 592316012835 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 592316012836 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 592316012837 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 592316012838 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316012839 DNA-binding site [nucleotide binding]; DNA binding site 592316012840 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316012841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316012842 homodimer interface [polypeptide binding]; other site 592316012843 catalytic residue [active] 592316012844 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 592316012845 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 592316012846 putative C-terminal domain interface [polypeptide binding]; other site 592316012847 putative GSH binding site (G-site) [chemical binding]; other site 592316012848 putative dimer interface [polypeptide binding]; other site 592316012849 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 592316012850 putative N-terminal domain interface [polypeptide binding]; other site 592316012851 putative dimer interface [polypeptide binding]; other site 592316012852 putative substrate binding pocket (H-site) [chemical binding]; other site 592316012853 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 592316012854 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 592316012855 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 592316012856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316012857 NAD(P) binding site [chemical binding]; other site 592316012858 active site 592316012859 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316012860 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316012861 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 592316012862 putative effector binding pocket; other site 592316012863 putative dimerization interface [polypeptide binding]; other site 592316012864 inner membrane protein YhjD; Region: TIGR00766 592316012865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316012866 metabolite-proton symporter; Region: 2A0106; TIGR00883 592316012867 putative substrate translocation pore; other site 592316012868 ketol-acid reductoisomerase; Validated; Region: PRK05225 592316012869 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 592316012870 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 592316012871 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 592316012872 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316012873 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 592316012874 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 592316012875 putative dimerization interface [polypeptide binding]; other site 592316012876 threonine dehydratase; Reviewed; Region: PRK09224 592316012877 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 592316012878 tetramer interface [polypeptide binding]; other site 592316012879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316012880 catalytic residue [active] 592316012881 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 592316012882 putative Ile/Val binding site [chemical binding]; other site 592316012883 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 592316012884 putative Ile/Val binding site [chemical binding]; other site 592316012885 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 592316012886 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 592316012887 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 592316012888 homodimer interface [polypeptide binding]; other site 592316012889 substrate-cofactor binding pocket; other site 592316012890 catalytic residue [active] 592316012891 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 592316012892 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 592316012893 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 592316012894 PYR/PP interface [polypeptide binding]; other site 592316012895 dimer interface [polypeptide binding]; other site 592316012896 TPP binding site [chemical binding]; other site 592316012897 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 592316012898 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 592316012899 TPP-binding site [chemical binding]; other site 592316012900 dimer interface [polypeptide binding]; other site 592316012901 putative ATP-dependent protease; Provisional; Region: PRK09862 592316012902 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 592316012903 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 592316012904 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 592316012905 hypothetical protein; Provisional; Region: PRK11027 592316012906 transcriptional regulator HdfR; Provisional; Region: PRK03601 592316012907 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316012908 LysR substrate binding domain; Region: LysR_substrate; pfam03466 592316012909 dimerization interface [polypeptide binding]; other site 592316012910 glutamate racemase; Provisional; Region: PRK00865 592316012911 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 592316012912 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316012913 N-terminal plug; other site 592316012914 ligand-binding site [chemical binding]; other site 592316012915 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 592316012916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316012917 S-adenosylmethionine binding site [chemical binding]; other site 592316012918 hypothetical protein; Provisional; Region: PRK11056 592316012919 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 592316012920 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316012921 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 592316012922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592316012923 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 592316012924 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 592316012925 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316012926 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 592316012927 dimerization interface [polypeptide binding]; other site 592316012928 argininosuccinate lyase; Provisional; Region: PRK04833 592316012929 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 592316012930 active sites [active] 592316012931 tetramer interface [polypeptide binding]; other site 592316012932 argininosuccinate synthase; Provisional; Region: PRK13820 592316012933 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 592316012934 ANP binding site [chemical binding]; other site 592316012935 Substrate Binding Site II [chemical binding]; other site 592316012936 Substrate Binding Site I [chemical binding]; other site 592316012937 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 592316012938 nucleotide binding site [chemical binding]; other site 592316012939 N-acetyl-L-glutamate binding site [chemical binding]; other site 592316012940 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 592316012941 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 592316012942 acetylornithine deacetylase; Provisional; Region: PRK05111 592316012943 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 592316012944 metal binding site [ion binding]; metal-binding site 592316012945 putative dimer interface [polypeptide binding]; other site 592316012946 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 592316012947 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 592316012948 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 592316012949 FAD binding site [chemical binding]; other site 592316012950 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 592316012951 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 592316012952 putative catalytic residues [active] 592316012953 putative nucleotide binding site [chemical binding]; other site 592316012954 putative aspartate binding site [chemical binding]; other site 592316012955 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 592316012956 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 592316012957 cystathionine gamma-synthase; Provisional; Region: PRK08045 592316012958 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 592316012959 homodimer interface [polypeptide binding]; other site 592316012960 substrate-cofactor binding pocket; other site 592316012961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316012962 catalytic residue [active] 592316012963 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 592316012964 dimerization interface [polypeptide binding]; other site 592316012965 DNA binding site [nucleotide binding] 592316012966 corepressor binding sites; other site 592316012967 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 592316012968 primosome assembly protein PriA; Validated; Region: PRK05580 592316012969 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592316012970 ATP binding site [chemical binding]; other site 592316012971 putative Mg++ binding site [ion binding]; other site 592316012972 helicase superfamily c-terminal domain; Region: HELICc; smart00490 592316012973 ATP-binding site [chemical binding]; other site 592316012974 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316012975 DNA binding site [nucleotide binding] 592316012976 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 592316012977 domain linker motif; other site 592316012978 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 592316012979 dimerization interface [polypeptide binding]; other site 592316012980 ligand binding site [chemical binding]; other site 592316012981 essential cell division protein FtsN; Provisional; Region: PRK10927 592316012982 cell division protein FtsN; Provisional; Region: PRK12757 592316012983 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 592316012984 active site 592316012985 HslU subunit interaction site [polypeptide binding]; other site 592316012986 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 592316012987 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316012988 Walker A motif; other site 592316012989 ATP binding site [chemical binding]; other site 592316012990 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 592316012991 Walker B motif; other site 592316012992 arginine finger; other site 592316012993 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 592316012994 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 592316012995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 592316012996 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 592316012997 amphipathic channel; other site 592316012998 Asn-Pro-Ala signature motifs; other site 592316012999 glycerol kinase; Provisional; Region: glpK; PRK00047 592316013000 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 592316013001 N- and C-terminal domain interface [polypeptide binding]; other site 592316013002 active site 592316013003 MgATP binding site [chemical binding]; other site 592316013004 catalytic site [active] 592316013005 metal binding site [ion binding]; metal-binding site 592316013006 glycerol binding site [chemical binding]; other site 592316013007 homotetramer interface [polypeptide binding]; other site 592316013008 homodimer interface [polypeptide binding]; other site 592316013009 FBP binding site [chemical binding]; other site 592316013010 protein IIAGlc interface [polypeptide binding]; other site 592316013011 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 592316013012 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 592316013013 putative active site [active] 592316013014 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 592316013015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316013016 putative substrate translocation pore; other site 592316013017 ferredoxin-NADP reductase; Provisional; Region: PRK10926 592316013018 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 592316013019 FAD binding pocket [chemical binding]; other site 592316013020 FAD binding motif [chemical binding]; other site 592316013021 phosphate binding motif [ion binding]; other site 592316013022 beta-alpha-beta structure motif; other site 592316013023 NAD binding pocket [chemical binding]; other site 592316013024 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 592316013025 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 592316013026 triosephosphate isomerase; Provisional; Region: PRK14567 592316013027 substrate binding site [chemical binding]; other site 592316013028 dimer interface [polypeptide binding]; other site 592316013029 catalytic triad [active] 592316013030 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 592316013031 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 592316013032 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316013033 substrate binding pocket [chemical binding]; other site 592316013034 membrane-bound complex binding site; other site 592316013035 hinge residues; other site 592316013036 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 592316013037 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 592316013038 active site 592316013039 ADP/pyrophosphate binding site [chemical binding]; other site 592316013040 dimerization interface [polypeptide binding]; other site 592316013041 allosteric effector site; other site 592316013042 fructose-1,6-bisphosphate binding site; other site 592316013043 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 592316013044 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 592316013045 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 592316013046 dimer interface [polypeptide binding]; other site 592316013047 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 592316013048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316013049 active site 592316013050 phosphorylation site [posttranslational modification] 592316013051 intermolecular recognition site; other site 592316013052 dimerization interface [polypeptide binding]; other site 592316013053 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592316013054 DNA binding site [nucleotide binding] 592316013055 two-component sensor protein; Provisional; Region: cpxA; PRK09470 592316013056 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592316013057 dimerization interface [polypeptide binding]; other site 592316013058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316013059 dimer interface [polypeptide binding]; other site 592316013060 phosphorylation site [posttranslational modification] 592316013061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316013062 ATP binding site [chemical binding]; other site 592316013063 Mg2+ binding site [ion binding]; other site 592316013064 G-X-G motif; other site 592316013065 putative rRNA methylase; Provisional; Region: PRK10358 592316013066 serine acetyltransferase; Provisional; Region: cysE; PRK11132 592316013067 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 592316013068 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 592316013069 trimer interface [polypeptide binding]; other site 592316013070 active site 592316013071 substrate binding site [chemical binding]; other site 592316013072 CoA binding site [chemical binding]; other site 592316013073 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 592316013074 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 592316013075 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 592316013076 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 592316013077 SecA binding site; other site 592316013078 Preprotein binding site; other site 592316013079 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 592316013080 GSH binding site [chemical binding]; other site 592316013081 catalytic residues [active] 592316013082 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 592316013083 active site residue [active] 592316013084 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 592316013085 Peptidase family M23; Region: Peptidase_M23; pfam01551 592316013086 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 592316013087 NodB motif; other site 592316013088 putative active site [active] 592316013089 putative catalytic site [active] 592316013090 Zn binding site [ion binding]; other site 592316013091 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 592316013092 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 592316013093 putative active site [active] 592316013094 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 592316013095 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 592316013096 putative active site [active] 592316013097 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 592316013098 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 592316013099 putative active site [active] 592316013100 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 592316013101 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 592316013102 putative active site [active] 592316013103 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 592316013104 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 592316013105 NADP binding site [chemical binding]; other site 592316013106 homopentamer interface [polypeptide binding]; other site 592316013107 substrate binding site [chemical binding]; other site 592316013108 active site 592316013109 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 592316013110 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 592316013111 substrate-cofactor binding pocket; other site 592316013112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316013113 catalytic residue [active] 592316013114 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 592316013115 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 592316013116 NAD(P) binding site [chemical binding]; other site 592316013117 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592316013118 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 592316013119 putative ADP-binding pocket [chemical binding]; other site 592316013120 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 592316013121 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 592316013122 putative active site [active] 592316013123 putative glycosyl transferase; Provisional; Region: PRK10073 592316013124 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 592316013125 active site 592316013126 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 592316013127 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 592316013128 putative active site [active] 592316013129 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592316013130 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 592316013131 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 592316013132 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 592316013133 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 592316013134 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 592316013135 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 592316013136 putative metal binding site; other site 592316013137 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 592316013138 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 592316013139 active site 592316013140 (T/H)XGH motif; other site 592316013141 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 592316013142 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 592316013143 DNA binding site [nucleotide binding] 592316013144 catalytic residue [active] 592316013145 H2TH interface [polypeptide binding]; other site 592316013146 putative catalytic residues [active] 592316013147 turnover-facilitating residue; other site 592316013148 intercalation triad [nucleotide binding]; other site 592316013149 8OG recognition residue [nucleotide binding]; other site 592316013150 putative reading head residues; other site 592316013151 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 592316013152 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 592316013153 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 592316013154 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 592316013155 hypothetical protein; Reviewed; Region: PRK00024 592316013156 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 592316013157 MPN+ (JAMM) motif; other site 592316013158 Zinc-binding site [ion binding]; other site 592316013159 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 592316013160 Flavoprotein; Region: Flavoprotein; pfam02441 592316013161 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 592316013162 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 592316013163 trimer interface [polypeptide binding]; other site 592316013164 active site 592316013165 division inhibitor protein; Provisional; Region: slmA; PRK09480 592316013166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316013167 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 592316013168 active site 592316013169 ribonuclease PH; Reviewed; Region: rph; PRK00173 592316013170 Ribonuclease PH; Region: RNase_PH_bact; cd11362 592316013171 hexamer interface [polypeptide binding]; other site 592316013172 active site 592316013173 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 592316013174 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 592316013175 Nucleoside recognition; Region: Gate; pfam07670 592316013176 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 592316013177 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 592316013178 hypothetical protein; Provisional; Region: PRK11820 592316013179 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 592316013180 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 592316013181 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 592316013182 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 592316013183 putative acyl-acceptor binding pocket; other site 592316013184 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 592316013185 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 592316013186 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 592316013187 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 592316013188 catalytic residue [active] 592316013189 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 592316013190 Predicted membrane protein [Function unknown]; Region: COG2860 592316013191 UPF0126 domain; Region: UPF0126; pfam03458 592316013192 UPF0126 domain; Region: UPF0126; pfam03458 592316013193 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 592316013194 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 592316013195 nucleotide binding pocket [chemical binding]; other site 592316013196 K-X-D-G motif; other site 592316013197 catalytic site [active] 592316013198 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 592316013199 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 592316013200 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 592316013201 catalytic site [active] 592316013202 G-X2-G-X-G-K; other site 592316013203 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 592316013204 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 592316013205 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592316013206 Zn2+ binding site [ion binding]; other site 592316013207 Mg2+ binding site [ion binding]; other site 592316013208 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 592316013209 synthetase active site [active] 592316013210 NTP binding site [chemical binding]; other site 592316013211 metal binding site [ion binding]; metal-binding site 592316013212 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 592316013213 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 592316013214 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 592316013215 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 592316013216 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 592316013217 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 592316013218 Y-family of DNA polymerases; Region: PolY; cl12025 592316013219 DNA binding site [nucleotide binding] 592316013220 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 592316013221 generic binding surface II; other site 592316013222 ssDNA binding site; other site 592316013223 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 592316013224 ATP binding site [chemical binding]; other site 592316013225 putative Mg++ binding site [ion binding]; other site 592316013226 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592316013227 nucleotide binding region [chemical binding]; other site 592316013228 ATP-binding site [chemical binding]; other site 592316013229 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592316013230 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592316013231 putative DNA binding site [nucleotide binding]; other site 592316013232 putative Zn2+ binding site [ion binding]; other site 592316013233 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 592316013234 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 592316013235 putative NAD(P) binding site [chemical binding]; other site 592316013236 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 592316013237 AsmA family; Region: AsmA; pfam05170 592316013238 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 592316013239 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592316013240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316013241 Coenzyme A binding pocket [chemical binding]; other site 592316013242 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 592316013243 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 592316013244 putative active site [active] 592316013245 dimerization interface [polypeptide binding]; other site 592316013246 putative tRNAtyr binding site [nucleotide binding]; other site 592316013247 hypothetical protein; Reviewed; Region: PRK01637 592316013248 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 592316013249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316013250 motif II; other site 592316013251 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 592316013252 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 592316013253 G1 box; other site 592316013254 putative GEF interaction site [polypeptide binding]; other site 592316013255 GTP/Mg2+ binding site [chemical binding]; other site 592316013256 Switch I region; other site 592316013257 G2 box; other site 592316013258 G3 box; other site 592316013259 Switch II region; other site 592316013260 G4 box; other site 592316013261 G5 box; other site 592316013262 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 592316013263 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 592316013264 glutamine synthetase; Provisional; Region: glnA; PRK09469 592316013265 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 592316013266 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 592316013267 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 592316013268 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 592316013269 putative active site [active] 592316013270 heme pocket [chemical binding]; other site 592316013271 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316013272 dimer interface [polypeptide binding]; other site 592316013273 phosphorylation site [posttranslational modification] 592316013274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316013275 ATP binding site [chemical binding]; other site 592316013276 Mg2+ binding site [ion binding]; other site 592316013277 G-X-G motif; other site 592316013278 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 592316013279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316013280 active site 592316013281 phosphorylation site [posttranslational modification] 592316013282 intermolecular recognition site; other site 592316013283 dimerization interface [polypeptide binding]; other site 592316013284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316013285 Walker A motif; other site 592316013286 ATP binding site [chemical binding]; other site 592316013287 Walker B motif; other site 592316013288 arginine finger; other site 592316013289 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 592316013290 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 592316013291 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592316013292 FeS/SAM binding site; other site 592316013293 HemN C-terminal domain; Region: HemN_C; pfam06969 592316013294 Der GTPase activator; Provisional; Region: PRK05244 592316013295 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 592316013296 G1 box; other site 592316013297 GTP/Mg2+ binding site [chemical binding]; other site 592316013298 Switch I region; other site 592316013299 G2 box; other site 592316013300 G3 box; other site 592316013301 Switch II region; other site 592316013302 G4 box; other site 592316013303 G5 box; other site 592316013304 DNA polymerase I; Provisional; Region: PRK05755 592316013305 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 592316013306 active site 592316013307 metal binding site 1 [ion binding]; metal-binding site 592316013308 putative 5' ssDNA interaction site; other site 592316013309 metal binding site 3; metal-binding site 592316013310 metal binding site 2 [ion binding]; metal-binding site 592316013311 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 592316013312 putative DNA binding site [nucleotide binding]; other site 592316013313 putative metal binding site [ion binding]; other site 592316013314 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 592316013315 active site 592316013316 catalytic site [active] 592316013317 substrate binding site [chemical binding]; other site 592316013318 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 592316013319 active site 592316013320 DNA binding site [nucleotide binding] 592316013321 catalytic site [active] 592316013322 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 592316013323 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 592316013324 catalytic residues [active] 592316013325 hinge region; other site 592316013326 alpha helical domain; other site 592316013327 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 592316013328 serine/threonine protein kinase; Provisional; Region: PRK11768 592316013329 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 592316013330 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 592316013331 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 592316013332 GTP binding site; other site 592316013333 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 592316013334 Walker A motif; other site 592316013335 putative transporter; Provisional; Region: PRK10504 592316013336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316013337 putative substrate translocation pore; other site 592316013338 transcriptional repressor RbsR; Provisional; Region: PRK10423 592316013339 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316013340 DNA binding site [nucleotide binding] 592316013341 domain linker motif; other site 592316013342 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 592316013343 dimerization interface [polypeptide binding]; other site 592316013344 ligand binding site [chemical binding]; other site 592316013345 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592316013346 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 592316013347 substrate binding site [chemical binding]; other site 592316013348 dimer interface [polypeptide binding]; other site 592316013349 ATP binding site [chemical binding]; other site 592316013350 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 592316013351 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 592316013352 ligand binding site [chemical binding]; other site 592316013353 dimerization interface [polypeptide binding]; other site 592316013354 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316013355 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592316013356 TM-ABC transporter signature motif; other site 592316013357 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 592316013358 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 592316013359 Walker A/P-loop; other site 592316013360 ATP binding site [chemical binding]; other site 592316013361 Q-loop/lid; other site 592316013362 ABC transporter signature motif; other site 592316013363 Walker B; other site 592316013364 D-loop; other site 592316013365 H-loop/switch region; other site 592316013366 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 592316013367 D-ribose pyranase; Provisional; Region: PRK11797 592316013368 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 592316013369 aromatic chitin/cellulose binding site residues [chemical binding]; other site 592316013370 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 592316013371 aromatic chitin/cellulose binding site residues [chemical binding]; other site 592316013372 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 592316013373 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 592316013374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316013375 active site 592316013376 phosphorylation site [posttranslational modification] 592316013377 intermolecular recognition site; other site 592316013378 dimerization interface [polypeptide binding]; other site 592316013379 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592316013380 DNA binding site [nucleotide binding] 592316013381 sensor protein QseC; Provisional; Region: PRK10337 592316013382 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316013383 dimer interface [polypeptide binding]; other site 592316013384 phosphorylation site [posttranslational modification] 592316013385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316013386 ATP binding site [chemical binding]; other site 592316013387 Mg2+ binding site [ion binding]; other site 592316013388 G-X-G motif; other site 592316013389 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 592316013390 potassium uptake protein; Region: kup; TIGR00794 592316013391 regulatory ATPase RavA; Provisional; Region: PRK13531 592316013392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316013393 Walker A motif; other site 592316013394 ATP binding site [chemical binding]; other site 592316013395 Walker B motif; other site 592316013396 arginine finger; other site 592316013397 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 592316013398 hypothetical protein; Provisional; Region: yieM; PRK10997 592316013399 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 592316013400 metal ion-dependent adhesion site (MIDAS); other site 592316013401 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 592316013402 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 592316013403 Methyltransferase domain; Region: Methyltransf_31; pfam13847 592316013404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316013405 S-adenosylmethionine binding site [chemical binding]; other site 592316013406 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 592316013407 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592316013408 putative DNA binding site [nucleotide binding]; other site 592316013409 putative Zn2+ binding site [ion binding]; other site 592316013410 AsnC family; Region: AsnC_trans_reg; pfam01037 592316013411 FMN-binding protein MioC; Provisional; Region: PRK09004 592316013412 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 592316013413 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 592316013414 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 592316013415 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 592316013416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316013417 S-adenosylmethionine binding site [chemical binding]; other site 592316013418 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 592316013419 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 592316013420 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 592316013421 ATP synthase, F0 subunit c; Region: ATP_synt_c; TIGR01260 592316013422 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 592316013423 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 592316013424 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 592316013425 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 592316013426 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 592316013427 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 592316013428 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 592316013429 Walker A motif; other site 592316013430 ATP binding site [chemical binding]; other site 592316013431 Walker B motif; other site 592316013432 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 592316013433 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 592316013434 core domain interface [polypeptide binding]; other site 592316013435 delta subunit interface [polypeptide binding]; other site 592316013436 epsilon subunit interface [polypeptide binding]; other site 592316013437 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 592316013438 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 592316013439 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 592316013440 alpha subunit interaction interface [polypeptide binding]; other site 592316013441 Walker A motif; other site 592316013442 ATP binding site [chemical binding]; other site 592316013443 Walker B motif; other site 592316013444 inhibitor binding site; inhibition site 592316013445 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 592316013446 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 592316013447 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 592316013448 gamma subunit interface [polypeptide binding]; other site 592316013449 epsilon subunit interface [polypeptide binding]; other site 592316013450 LBP interface [polypeptide binding]; other site 592316013451 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 592316013452 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 592316013453 Substrate binding site; other site 592316013454 Mg++ binding site; other site 592316013455 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 592316013456 active site 592316013457 substrate binding site [chemical binding]; other site 592316013458 CoA binding site [chemical binding]; other site 592316013459 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 592316013460 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 592316013461 glutaminase active site [active] 592316013462 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 592316013463 dimer interface [polypeptide binding]; other site 592316013464 active site 592316013465 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 592316013466 dimer interface [polypeptide binding]; other site 592316013467 active site 592316013468 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316013469 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 592316013470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316013471 dimer interface [polypeptide binding]; other site 592316013472 conserved gate region; other site 592316013473 putative PBP binding loops; other site 592316013474 ABC-ATPase subunit interface; other site 592316013475 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 592316013476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316013477 dimer interface [polypeptide binding]; other site 592316013478 conserved gate region; other site 592316013479 putative PBP binding loops; other site 592316013480 ABC-ATPase subunit interface; other site 592316013481 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 592316013482 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 592316013483 Walker A/P-loop; other site 592316013484 ATP binding site [chemical binding]; other site 592316013485 Q-loop/lid; other site 592316013486 ABC transporter signature motif; other site 592316013487 Walker B; other site 592316013488 D-loop; other site 592316013489 H-loop/switch region; other site 592316013490 transcriptional regulator PhoU; Provisional; Region: PRK11115 592316013491 PhoU domain; Region: PhoU; pfam01895 592316013492 PhoU domain; Region: PhoU; pfam01895 592316013493 benzoate transport; Region: 2A0115; TIGR00895 592316013494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316013495 putative substrate translocation pore; other site 592316013496 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 592316013497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316013498 motif II; other site 592316013499 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 592316013500 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 592316013501 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 592316013502 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 592316013503 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 592316013504 putative FMN binding site [chemical binding]; other site 592316013505 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 592316013506 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 592316013507 trmE is a tRNA modification GTPase; Region: trmE; cd04164 592316013508 G1 box; other site 592316013509 GTP/Mg2+ binding site [chemical binding]; other site 592316013510 Switch I region; other site 592316013511 G2 box; other site 592316013512 Switch II region; other site 592316013513 G3 box; other site 592316013514 G4 box; other site 592316013515 G5 box; other site 592316013516 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 592316013517 membrane protein insertase; Provisional; Region: PRK01318 592316013518 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 592316013519 hypothetical protein; Validated; Region: PRK00041 592316013520 ribonuclease P; Reviewed; Region: rnpA; PRK01732 592316013521 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 592316013522 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 592316013523 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 592316013524 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 592316013525 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 592316013526 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 592316013527 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 592316013528 active site 592316013529 FMN binding site [chemical binding]; other site 592316013530 substrate binding site [chemical binding]; other site 592316013531 homotetramer interface [polypeptide binding]; other site 592316013532 catalytic residue [active] 592316013533 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 592316013534 DNA-binding site [nucleotide binding]; DNA binding site 592316013535 RNA-binding motif; other site 592316013536 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 592316013537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316013538 DNA-binding site [nucleotide binding]; DNA binding site 592316013539 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316013540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316013541 homodimer interface [polypeptide binding]; other site 592316013542 catalytic residue [active] 592316013543 EamA-like transporter family; Region: EamA; pfam00892 592316013544 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 592316013545 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 592316013546 intersubunit interface [polypeptide binding]; other site 592316013547 Transcriptional regulator [Transcription]; Region: IclR; COG1414 592316013548 Bacterial transcriptional regulator; Region: IclR; pfam01614 592316013549 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 592316013550 homotrimer interaction site [polypeptide binding]; other site 592316013551 putative active site [active] 592316013552 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316013553 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316013554 substrate binding pocket [chemical binding]; other site 592316013555 membrane-bound complex binding site; other site 592316013556 hinge residues; other site 592316013557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316013558 dimer interface [polypeptide binding]; other site 592316013559 conserved gate region; other site 592316013560 putative PBP binding loops; other site 592316013561 ABC-ATPase subunit interface; other site 592316013562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316013563 dimer interface [polypeptide binding]; other site 592316013564 conserved gate region; other site 592316013565 putative PBP binding loops; other site 592316013566 ABC-ATPase subunit interface; other site 592316013567 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316013568 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316013569 Walker A/P-loop; other site 592316013570 ATP binding site [chemical binding]; other site 592316013571 Q-loop/lid; other site 592316013572 ABC transporter signature motif; other site 592316013573 Walker B; other site 592316013574 D-loop; other site 592316013575 H-loop/switch region; other site 592316013576 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 592316013577 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 592316013578 active site 592316013579 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 592316013580 dimer interface [polypeptide binding]; other site 592316013581 substrate binding site [chemical binding]; other site 592316013582 catalytic residue [active] 592316013583 short chain dehydrogenase; Provisional; Region: PRK06940 592316013584 classical (c) SDRs; Region: SDR_c; cd05233 592316013585 NAD(P) binding site [chemical binding]; other site 592316013586 active site 592316013587 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316013588 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316013589 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 592316013590 putative effector binding pocket; other site 592316013591 putative dimerization interface [polypeptide binding]; other site 592316013592 PAAR motif; Region: PAAR_motif; pfam05488 592316013593 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 592316013594 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 592316013595 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 592316013596 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 592316013597 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 592316013598 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 592316013599 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 592316013600 aspartate racemase; Region: asp_race; TIGR00035 592316013601 Fusaric acid resistance protein family; Region: FUSC; pfam04632 592316013602 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 592316013603 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 592316013604 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316013605 substrate binding pocket [chemical binding]; other site 592316013606 membrane-bound complex binding site; other site 592316013607 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 592316013608 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 592316013609 Flavin binding site [chemical binding]; other site 592316013610 benzoate transport; Region: 2A0115; TIGR00895 592316013611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316013612 putative substrate translocation pore; other site 592316013613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316013614 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 592316013615 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 592316013616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316013617 dimer interface [polypeptide binding]; other site 592316013618 conserved gate region; other site 592316013619 ABC-ATPase subunit interface; other site 592316013620 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 592316013621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316013622 Walker A/P-loop; other site 592316013623 ATP binding site [chemical binding]; other site 592316013624 Q-loop/lid; other site 592316013625 ABC transporter signature motif; other site 592316013626 Walker B; other site 592316013627 D-loop; other site 592316013628 H-loop/switch region; other site 592316013629 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 592316013630 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 592316013631 active site 592316013632 non-prolyl cis peptide bond; other site 592316013633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 592316013634 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 592316013635 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 592316013636 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 592316013637 active site 592316013638 dimer interface [polypeptide binding]; other site 592316013639 non-prolyl cis peptide bond; other site 592316013640 insertion regions; other site 592316013641 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 592316013642 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316013643 Walker A motif; other site 592316013644 ATP binding site [chemical binding]; other site 592316013645 Walker B motif; other site 592316013646 arginine finger; other site 592316013647 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 592316013648 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 592316013649 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316013650 substrate binding pocket [chemical binding]; other site 592316013651 membrane-bound complex binding site; other site 592316013652 hinge residues; other site 592316013653 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 592316013654 ParB-like nuclease domain; Region: ParB; smart00470 592316013655 ParB family; Region: ParB; pfam08775 592316013656 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 592316013657 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 592316013658 P-loop; other site 592316013659 Magnesium ion binding site [ion binding]; other site 592316013660 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 592316013661 Magnesium ion binding site [ion binding]; other site 592316013662 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 592316013663 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 592316013664 NAD(P) binding site [chemical binding]; other site 592316013665 catalytic residues [active] 592316013666 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 592316013667 active site 592316013668 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 592316013669 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 592316013670 XdhC Rossmann domain; Region: XdhC_C; pfam13478 592316013671 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 592316013672 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 592316013673 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 592316013674 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 592316013675 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316013676 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316013677 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 592316013678 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 592316013679 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 592316013680 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 592316013681 MarR family; Region: MarR_2; cl17246 592316013682 Transcriptional regulators [Transcription]; Region: MarR; COG1846 592316013683 hypothetical protein; Provisional; Region: PRK06847 592316013684 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 592316013685 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592316013686 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 592316013687 Isochorismatase family; Region: Isochorismatase; pfam00857 592316013688 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 592316013689 catalytic triad [active] 592316013690 substrate binding site [chemical binding]; other site 592316013691 domain interfaces; other site 592316013692 conserved cis-peptide bond; other site 592316013693 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 592316013694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316013695 putative substrate translocation pore; other site 592316013696 nucleoside transporter; Region: 2A0110; TIGR00889 592316013697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316013698 putative substrate translocation pore; other site 592316013699 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 592316013700 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 592316013701 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592316013702 substrate binding site [chemical binding]; other site 592316013703 ATP binding site [chemical binding]; other site 592316013704 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 592316013705 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316013706 DNA-binding site [nucleotide binding]; DNA binding site 592316013707 UTRA domain; Region: UTRA; pfam07702 592316013708 S-type Pyocin; Region: Pyocin_S; pfam06958 592316013709 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 592316013710 active site 592316013711 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 592316013712 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 592316013713 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316013714 Coenzyme A binding pocket [chemical binding]; other site 592316013715 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 592316013716 active site 1 [active] 592316013717 dimer interface [polypeptide binding]; other site 592316013718 hexamer interface [polypeptide binding]; other site 592316013719 active site 2 [active] 592316013720 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 592316013721 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 592316013722 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 592316013723 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 592316013724 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316013725 DNA-binding site [nucleotide binding]; DNA binding site 592316013726 FCD domain; Region: FCD; pfam07729 592316013727 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 592316013728 active site 592316013729 catalytic triad [active] 592316013730 oxyanion hole [active] 592316013731 Acyltransferase family; Region: Acyl_transf_3; pfam01757 592316013732 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 592316013733 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592316013734 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 592316013735 substrate binding site [chemical binding]; other site 592316013736 ATP binding site [chemical binding]; other site 592316013737 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 592316013738 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 592316013739 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 592316013740 ligand binding site [chemical binding]; other site 592316013741 NAD binding site [chemical binding]; other site 592316013742 catalytic site [active] 592316013743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316013744 putative substrate translocation pore; other site 592316013745 Major royal jelly protein; Region: MRJP; pfam03022 592316013746 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592316013747 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316013748 non-specific DNA binding site [nucleotide binding]; other site 592316013749 salt bridge; other site 592316013750 sequence-specific DNA binding site [nucleotide binding]; other site 592316013751 Cupin domain; Region: Cupin_2; cl17218 592316013752 AzlC protein; Region: AzlC; cl00570 592316013753 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 592316013754 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592316013755 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 592316013756 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 592316013757 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316013758 Coenzyme A binding pocket [chemical binding]; other site 592316013759 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 592316013760 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 592316013761 oligomer interface [polypeptide binding]; other site 592316013762 metal binding site [ion binding]; metal-binding site 592316013763 metal binding site [ion binding]; metal-binding site 592316013764 putative Cl binding site [ion binding]; other site 592316013765 basic sphincter; other site 592316013766 hydrophobic gate; other site 592316013767 periplasmic entrance; other site 592316013768 putative amidase; Provisional; Region: PRK06169 592316013769 Amidase; Region: Amidase; pfam01425 592316013770 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 592316013771 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 592316013772 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 592316013773 allantoate amidohydrolase; Reviewed; Region: PRK09290 592316013774 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 592316013775 active site 592316013776 metal binding site [ion binding]; metal-binding site 592316013777 dimer interface [polypeptide binding]; other site 592316013778 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 592316013779 active site 592316013780 ATP binding site [chemical binding]; other site 592316013781 Phosphotransferase enzyme family; Region: APH; pfam01636 592316013782 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 592316013783 substrate binding site [chemical binding]; other site 592316013784 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 592316013785 Phosphotransferase enzyme family; Region: APH; pfam01636 592316013786 active site 592316013787 ATP binding site [chemical binding]; other site 592316013788 substrate binding site [chemical binding]; other site 592316013789 dimer interface [polypeptide binding]; other site 592316013790 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 592316013791 Na binding site [ion binding]; other site 592316013792 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316013793 non-specific DNA binding site [nucleotide binding]; other site 592316013794 salt bridge; other site 592316013795 sequence-specific DNA binding site [nucleotide binding]; other site 592316013796 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 592316013797 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 592316013798 conserved cys residue [active] 592316013799 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 592316013800 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592316013801 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 592316013802 Walker A/P-loop; other site 592316013803 ATP binding site [chemical binding]; other site 592316013804 Q-loop/lid; other site 592316013805 ABC transporter signature motif; other site 592316013806 Walker B; other site 592316013807 D-loop; other site 592316013808 H-loop/switch region; other site 592316013809 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 592316013810 FecCD transport family; Region: FecCD; pfam01032 592316013811 ABC-ATPase subunit interface; other site 592316013812 dimer interface [polypeptide binding]; other site 592316013813 putative PBP binding regions; other site 592316013814 FecCD transport family; Region: FecCD; pfam01032 592316013815 ABC-ATPase subunit interface; other site 592316013816 dimer interface [polypeptide binding]; other site 592316013817 putative PBP binding regions; other site 592316013818 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 592316013819 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 592316013820 intersubunit interface [polypeptide binding]; other site 592316013821 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 592316013822 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316013823 N-terminal plug; other site 592316013824 ligand-binding site [chemical binding]; other site 592316013825 Cupin domain; Region: Cupin_2; pfam07883 592316013826 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316013827 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592316013828 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316013829 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 592316013830 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 592316013831 putative NAD(P) binding site [chemical binding]; other site 592316013832 putative active site [active] 592316013833 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 592316013834 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316013835 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 592316013836 dimerization interface [polypeptide binding]; other site 592316013837 substrate binding pocket [chemical binding]; other site 592316013838 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 592316013839 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 592316013840 metal binding site [ion binding]; metal-binding site 592316013841 dimer interface [polypeptide binding]; other site 592316013842 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316013843 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316013844 substrate binding pocket [chemical binding]; other site 592316013845 membrane-bound complex binding site; other site 592316013846 hinge residues; other site 592316013847 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316013848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316013849 dimer interface [polypeptide binding]; other site 592316013850 conserved gate region; other site 592316013851 putative PBP binding loops; other site 592316013852 ABC-ATPase subunit interface; other site 592316013853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316013854 dimer interface [polypeptide binding]; other site 592316013855 conserved gate region; other site 592316013856 putative PBP binding loops; other site 592316013857 ABC-ATPase subunit interface; other site 592316013858 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 592316013859 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316013860 Walker A/P-loop; other site 592316013861 ATP binding site [chemical binding]; other site 592316013862 Q-loop/lid; other site 592316013863 ABC transporter signature motif; other site 592316013864 Walker B; other site 592316013865 D-loop; other site 592316013866 H-loop/switch region; other site 592316013867 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 592316013868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316013869 active site 592316013870 phosphorylation site [posttranslational modification] 592316013871 intermolecular recognition site; other site 592316013872 dimerization interface [polypeptide binding]; other site 592316013873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316013874 dimer interface [polypeptide binding]; other site 592316013875 conserved gate region; other site 592316013876 putative PBP binding loops; other site 592316013877 ABC-ATPase subunit interface; other site 592316013878 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 592316013879 tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730 592316013880 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 592316013881 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 592316013882 putative NAD(P) binding site [chemical binding]; other site 592316013883 putative substrate binding site [chemical binding]; other site 592316013884 catalytic Zn binding site [ion binding]; other site 592316013885 structural Zn binding site [ion binding]; other site 592316013886 dimer interface [polypeptide binding]; other site 592316013887 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 592316013888 FOG: Zn-finger [General function prediction only]; Region: COG5048 592316013889 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 592316013890 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 592316013891 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 592316013892 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 592316013893 glycerate dehydrogenase; Provisional; Region: PRK06932 592316013894 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 592316013895 putative ligand binding site [chemical binding]; other site 592316013896 putative NAD binding site [chemical binding]; other site 592316013897 catalytic site [active] 592316013898 glutaminase; Provisional; Region: PRK00971 592316013899 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 592316013900 nif11 domain/cupin domain protein; Region: nif11_cupin; TIGR03890 592316013901 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 592316013902 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 592316013903 Cl- selectivity filter; other site 592316013904 Cl- binding residues [ion binding]; other site 592316013905 pore gating glutamate residue; other site 592316013906 dimer interface [polypeptide binding]; other site 592316013907 H+/Cl- coupling transport residue; other site 592316013908 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 592316013909 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 592316013910 active site pocket [active] 592316013911 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592316013912 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316013913 DNA binding site [nucleotide binding] 592316013914 domain linker motif; other site 592316013915 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 592316013916 putative dimerization interface [polypeptide binding]; other site 592316013917 putative ligand binding site [chemical binding]; other site 592316013918 Domain of unknown function (DUF336); Region: DUF336; cl01249 592316013919 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316013920 Cytochrome c; Region: Cytochrom_C; pfam00034 592316013921 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316013922 Cytochrome c; Region: Cytochrom_C; pfam00034 592316013923 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 592316013924 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 592316013925 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 592316013926 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 592316013927 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 592316013928 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592316013929 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316013930 DNA binding site [nucleotide binding] 592316013931 domain linker motif; other site 592316013932 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 592316013933 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 592316013934 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 592316013935 putative ligand binding site [chemical binding]; other site 592316013936 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592316013937 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592316013938 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592316013939 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 592316013940 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 592316013941 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 592316013942 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 592316013943 active site 592316013944 dimer interface [polypeptide binding]; other site 592316013945 non-prolyl cis peptide bond; other site 592316013946 insertion regions; other site 592316013947 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 592316013948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316013949 putative substrate translocation pore; other site 592316013950 Putative motility protein; Region: YjfB_motility; pfam14070 592316013951 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 592316013952 DNA-binding site [nucleotide binding]; DNA binding site 592316013953 RNA-binding motif; other site 592316013954 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 592316013955 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 592316013956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 592316013957 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 592316013958 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 592316013959 Flavoprotein; Region: Flavoprotein; pfam02441 592316013960 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592316013961 MarR family; Region: MarR_2; cl17246 592316013962 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 592316013963 beta-carotene hydroxylase; Region: PLN02601 592316013964 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 592316013965 active site lid residues [active] 592316013966 substrate binding pocket [chemical binding]; other site 592316013967 catalytic residues [active] 592316013968 substrate-Mg2+ binding site; other site 592316013969 aspartate-rich region 1; other site 592316013970 aspartate-rich region 2; other site 592316013971 phytoene desaturase; Region: crtI_fam; TIGR02734 592316013972 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592316013973 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 592316013974 lycopene cyclase; Region: lycopene_cycl; TIGR01789 592316013975 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 592316013976 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 592316013977 substrate binding pocket [chemical binding]; other site 592316013978 chain length determination region; other site 592316013979 substrate-Mg2+ binding site; other site 592316013980 catalytic residues [active] 592316013981 aspartate-rich region 1; other site 592316013982 active site lid residues [active] 592316013983 aspartate-rich region 2; other site 592316013984 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 592316013985 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 592316013986 putative ligand binding site [chemical binding]; other site 592316013987 NAD binding site [chemical binding]; other site 592316013988 catalytic site [active] 592316013989 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 592316013990 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592316013991 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592316013992 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592316013993 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592316013994 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 592316013995 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316013996 Walker A/P-loop; other site 592316013997 ATP binding site [chemical binding]; other site 592316013998 Q-loop/lid; other site 592316013999 ABC transporter signature motif; other site 592316014000 Walker B; other site 592316014001 D-loop; other site 592316014002 H-loop/switch region; other site 592316014003 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316014004 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 592316014005 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316014006 Walker A/P-loop; other site 592316014007 ATP binding site [chemical binding]; other site 592316014008 Q-loop/lid; other site 592316014009 ABC transporter signature motif; other site 592316014010 Walker B; other site 592316014011 D-loop; other site 592316014012 H-loop/switch region; other site 592316014013 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316014014 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 592316014015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316014016 dimer interface [polypeptide binding]; other site 592316014017 conserved gate region; other site 592316014018 putative PBP binding loops; other site 592316014019 ABC-ATPase subunit interface; other site 592316014020 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316014021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316014022 dimer interface [polypeptide binding]; other site 592316014023 conserved gate region; other site 592316014024 putative PBP binding loops; other site 592316014025 ABC-ATPase subunit interface; other site 592316014026 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592316014027 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 592316014028 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 592316014029 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 592316014030 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 592316014031 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 592316014032 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 592316014033 putative NAD(P) binding site [chemical binding]; other site 592316014034 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316014035 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316014036 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 592316014037 putative effector binding pocket; other site 592316014038 dimerization interface [polypeptide binding]; other site 592316014039 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316014040 salt bridge; other site 592316014041 non-specific DNA binding site [nucleotide binding]; other site 592316014042 sequence-specific DNA binding site [nucleotide binding]; other site 592316014043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316014044 putative substrate translocation pore; other site 592316014045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316014046 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 592316014047 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 592316014048 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 592316014049 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 592316014050 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 592316014051 Surface antigen; Region: Bac_surface_Ag; pfam01103 592316014052 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 592316014053 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 592316014054 Walker A/P-loop; other site 592316014055 ATP binding site [chemical binding]; other site 592316014056 Q-loop/lid; other site 592316014057 ABC transporter signature motif; other site 592316014058 Walker B; other site 592316014059 D-loop; other site 592316014060 H-loop/switch region; other site 592316014061 TOBE domain; Region: TOBE_2; pfam08402 592316014062 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592316014063 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 592316014064 substrate binding site [chemical binding]; other site 592316014065 ATP binding site [chemical binding]; other site 592316014066 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 592316014067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316014068 dimer interface [polypeptide binding]; other site 592316014069 conserved gate region; other site 592316014070 putative PBP binding loops; other site 592316014071 ABC-ATPase subunit interface; other site 592316014072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316014073 dimer interface [polypeptide binding]; other site 592316014074 conserved gate region; other site 592316014075 putative PBP binding loops; other site 592316014076 ABC-ATPase subunit interface; other site 592316014077 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 592316014078 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 592316014079 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 592316014080 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 592316014081 nucleotide binding site [chemical binding]; other site 592316014082 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 592316014083 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592316014084 subtilase cytotoxin subunit B-like protein; Provisional; Region: PRK15265; cl14664 592316014085 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 592316014086 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 592316014087 active site 592316014088 metal binding site [ion binding]; metal-binding site 592316014089 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 592316014090 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 592316014091 tetramer interface [polypeptide binding]; other site 592316014092 active site 592316014093 Mg2+/Mn2+ binding site [ion binding]; other site 592316014094 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 592316014095 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 592316014096 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 592316014097 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 592316014098 DNA binding site [nucleotide binding] 592316014099 active site 592316014100 molybdenum-pterin binding domain; Region: Mop; TIGR00638 592316014101 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 592316014102 Membrane transport protein; Region: Mem_trans; cl09117 592316014103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316014104 Coenzyme A binding pocket [chemical binding]; other site 592316014105 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 592316014106 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 592316014107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 592316014108 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 592316014109 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 592316014110 active site 592316014111 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 592316014112 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 592316014113 active site 592316014114 metal binding site [ion binding]; metal-binding site 592316014115 Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Region: ArgF; COG0078 592316014116 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 592316014117 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 592316014118 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930 592316014119 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 592316014120 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 592316014121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 592316014122 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 592316014123 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 592316014124 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 592316014125 Uncharacterized conserved protein [Function unknown]; Region: COG1262 592316014126 Proline dehydrogenase; Region: Pro_dh; cl03282 592316014127 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 592316014128 active site 592316014129 iron coordination sites [ion binding]; other site 592316014130 substrate binding pocket [chemical binding]; other site 592316014131 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 592316014132 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 592316014133 substrate binding site [chemical binding]; other site 592316014134 oxyanion hole (OAH) forming residues; other site 592316014135 trimer interface [polypeptide binding]; other site 592316014136 Domain of unknown function (DUF1933); Region: DUF1933; pfam09147 592316014137 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 592316014138 active site 592316014139 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 592316014140 Ligand Binding Site [chemical binding]; other site 592316014141 Molecular Tunnel; other site 592316014142 PAS fold; Region: PAS_4; pfam08448 592316014143 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 592316014144 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592316014145 DNA binding residues [nucleotide binding] 592316014146 TraY domain; Region: TraY; pfam05509 592316014147 malate:quinone oxidoreductase; Validated; Region: PRK05257 592316014148 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 592316014149 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592316014150 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 592316014151 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 592316014152 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316014153 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316014154 dimerization interface [polypeptide binding]; other site 592316014155 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 592316014156 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 592316014157 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 592316014158 hexamer interface [polypeptide binding]; other site 592316014159 active site 2 [active] 592316014160 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 592316014161 putative trimer interface [polypeptide binding]; other site 592316014162 putative active site [active] 592316014163 putative substrate binding site [chemical binding]; other site 592316014164 putative CoA binding site [chemical binding]; other site 592316014165 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 592316014166 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316014167 Walker A/P-loop; other site 592316014168 ATP binding site [chemical binding]; other site 592316014169 Q-loop/lid; other site 592316014170 ABC transporter signature motif; other site 592316014171 Walker B; other site 592316014172 D-loop; other site 592316014173 H-loop/switch region; other site 592316014174 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316014175 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316014176 Walker A/P-loop; other site 592316014177 ATP binding site [chemical binding]; other site 592316014178 Q-loop/lid; other site 592316014179 ABC transporter signature motif; other site 592316014180 Walker B; other site 592316014181 D-loop; other site 592316014182 H-loop/switch region; other site 592316014183 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 592316014184 Uncharacterized conserved protein [Function unknown]; Region: COG5476 592316014185 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 592316014186 MlrC C-terminus; Region: MlrC_C; pfam07171 592316014187 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592316014188 putative DNA binding site [nucleotide binding]; other site 592316014189 putative Zn2+ binding site [ion binding]; other site 592316014190 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 592316014191 nucleotide binding site [chemical binding]; other site 592316014192 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 592316014193 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 592316014194 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 592316014195 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316014196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316014197 dimer interface [polypeptide binding]; other site 592316014198 conserved gate region; other site 592316014199 putative PBP binding loops; other site 592316014200 ABC-ATPase subunit interface; other site 592316014201 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 592316014202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316014203 dimer interface [polypeptide binding]; other site 592316014204 conserved gate region; other site 592316014205 putative PBP binding loops; other site 592316014206 ABC-ATPase subunit interface; other site 592316014207 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 592316014208 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 592316014209 nucleotide binding site [chemical binding]; other site 592316014210 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 592316014211 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 592316014212 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316014213 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316014214 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 592316014215 putative effector binding pocket; other site 592316014216 dimerization interface [polypeptide binding]; other site 592316014217 Pirin-related protein [General function prediction only]; Region: COG1741 592316014218 Pirin; Region: Pirin; pfam02678 592316014219 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592316014220 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592316014221 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592316014222 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316014223 DNA binding site [nucleotide binding] 592316014224 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 592316014225 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 592316014226 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 592316014227 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 592316014228 thiS-thiF/thiG interaction site; other site 592316014229 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 592316014230 ThiS interaction site; other site 592316014231 putative active site [active] 592316014232 tetramer interface [polypeptide binding]; other site 592316014233 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 592316014234 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 592316014235 ATP binding site [chemical binding]; other site 592316014236 substrate interface [chemical binding]; other site 592316014237 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 592316014238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316014239 Walker A/P-loop; other site 592316014240 ATP binding site [chemical binding]; other site 592316014241 Q-loop/lid; other site 592316014242 ABC transporter signature motif; other site 592316014243 Walker B; other site 592316014244 D-loop; other site 592316014245 H-loop/switch region; other site 592316014246 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 592316014247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316014248 dimer interface [polypeptide binding]; other site 592316014249 conserved gate region; other site 592316014250 putative PBP binding loops; other site 592316014251 ABC-ATPase subunit interface; other site 592316014252 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 592316014253 NMT1/THI5 like; Region: NMT1; pfam09084 592316014254 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 592316014255 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 592316014256 siderophore binding site; other site 592316014257 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 592316014258 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 592316014259 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 592316014260 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 592316014261 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316014262 N-terminal plug; other site 592316014263 ligand-binding site [chemical binding]; other site 592316014264 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 592316014265 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 592316014266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316014267 Walker A motif; other site 592316014268 ATP binding site [chemical binding]; other site 592316014269 Walker B motif; other site 592316014270 arginine finger; other site 592316014271 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 592316014272 DNA-binding interface [nucleotide binding]; DNA binding site 592316014273 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 592316014274 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 592316014275 putative NAD(P) binding site [chemical binding]; other site 592316014276 catalytic Zn binding site [ion binding]; other site 592316014277 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 592316014278 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 592316014279 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 592316014280 dimer interface [polypeptide binding]; other site 592316014281 active site 592316014282 Int/Topo IB signature motif; other site 592316014283 Excisionase-like protein; Region: Exc; pfam07825 592316014284 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 592316014285 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 592316014286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316014287 non-specific DNA binding site [nucleotide binding]; other site 592316014288 Predicted transcriptional regulator [Transcription]; Region: COG2932 592316014289 salt bridge; other site 592316014290 sequence-specific DNA binding site [nucleotide binding]; other site 592316014291 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 592316014292 Catalytic site [active] 592316014293 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 592316014294 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316014295 DNA-binding site [nucleotide binding]; DNA binding site 592316014296 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 592316014297 MarR family; Region: MarR_2; cl17246 592316014298 ParB-like nuclease domain; Region: ParB; smart00470 592316014299 KorB domain; Region: KorB; pfam08535 592316014300 MT-A70; Region: MT-A70; cl01947 592316014301 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 592316014302 Protein of unknown function (DUF968); Region: DUF968; pfam06147 592316014303 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 592316014304 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 592316014305 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 592316014306 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 592316014307 Protein of unknown function (DUF1378); Region: DUF1378; pfam07125 592316014308 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 592316014309 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 592316014310 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 592316014311 active site 592316014312 Phage terminase, small subunit; Region: Terminase_4; cl01525 592316014313 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 592316014314 Phage-related protein [Function unknown]; Region: COG4695 592316014315 Phage portal protein; Region: Phage_portal; pfam04860 592316014316 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 592316014317 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 592316014318 Phage capsid family; Region: Phage_capsid; pfam05065 592316014319 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 592316014320 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 592316014321 oligomerization interface [polypeptide binding]; other site 592316014322 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 592316014323 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 592316014324 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 592316014325 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 592316014326 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 592316014327 Phage-related minor tail protein [Function unknown]; Region: COG5281 592316014328 tape measure domain; Region: tape_meas_nterm; TIGR02675 592316014329 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 592316014330 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 592316014331 Phage minor tail protein; Region: Phage_min_tail; cl01940 592316014332 Phage minor tail protein L; Region: Phage_tail_L; cl01908 592316014333 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 592316014334 MPN+ (JAMM) motif; other site 592316014335 Zinc-binding site [ion binding]; other site 592316014336 NlpC/P60 family; Region: NLPC_P60; pfam00877 592316014337 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 592316014338 Phage-related protein, tail component [Function unknown]; Region: COG4723 592316014339 Phage-related protein, tail component [Function unknown]; Region: COG4733 592316014340 Putative phage tail protein; Region: Phage-tail_3; pfam13550 592316014341 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 592316014342 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 592316014343 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 592316014344 Restriction endonuclease; Region: Mrr_cat; pfam04471 592316014345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316014346 non-specific DNA binding site [nucleotide binding]; other site 592316014347 salt bridge; other site 592316014348 sequence-specific DNA binding site [nucleotide binding]; other site 592316014349 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 592316014350 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316014351 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316014352 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 592316014353 putative effector binding pocket; other site 592316014354 dimerization interface [polypeptide binding]; other site 592316014355 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 592316014356 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 592316014357 putative NAD(P) binding site [chemical binding]; other site 592316014358 dimer interface [polypeptide binding]; other site 592316014359 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 592316014360 FMN binding site [chemical binding]; other site 592316014361 dimer interface [polypeptide binding]; other site 592316014362 SopA-like catalytic domain; Region: SopA_C; pfam13979 592316014363 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 592316014364 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316014365 substrate binding pocket [chemical binding]; other site 592316014366 membrane-bound complex binding site; other site 592316014367 hinge residues; other site 592316014368 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 592316014369 putative active site [active] 592316014370 Zn binding site [ion binding]; other site 592316014371 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 592316014372 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316014373 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316014374 dimerization interface [polypeptide binding]; other site 592316014375 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 592316014376 Amidinotransferase; Region: Amidinotransf; pfam02274 592316014377 agmatinase; Region: agmatinase; TIGR01230 592316014378 Agmatinase-like family; Region: Agmatinase-like; cd09990 592316014379 active site 592316014380 oligomer interface [polypeptide binding]; other site 592316014381 Mn binding site [ion binding]; other site 592316014382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316014383 dimer interface [polypeptide binding]; other site 592316014384 conserved gate region; other site 592316014385 putative PBP binding loops; other site 592316014386 ABC-ATPase subunit interface; other site 592316014387 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316014388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316014389 dimer interface [polypeptide binding]; other site 592316014390 conserved gate region; other site 592316014391 putative PBP binding loops; other site 592316014392 ABC-ATPase subunit interface; other site 592316014393 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316014394 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316014395 substrate binding pocket [chemical binding]; other site 592316014396 membrane-bound complex binding site; other site 592316014397 hinge residues; other site 592316014398 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 592316014399 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316014400 non-specific DNA binding site [nucleotide binding]; other site 592316014401 salt bridge; other site 592316014402 sequence-specific DNA binding site [nucleotide binding]; other site 592316014403 Cupin domain; Region: Cupin_2; pfam07883 592316014404 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 592316014405 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 592316014406 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 592316014407 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316014408 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592316014409 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316014410 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 592316014411 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 592316014412 Amidase; Region: Amidase; cl11426 592316014413 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 592316014414 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316014415 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316014416 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 592316014417 putative substrate binding pocket [chemical binding]; other site 592316014418 putative dimerization interface [polypeptide binding]; other site 592316014419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316014420 C factor cell-cell signaling protein; Provisional; Region: PRK09009 592316014421 NAD(P) binding site [chemical binding]; other site 592316014422 active site 592316014423 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316014424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316014425 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 592316014426 putative substrate binding pocket [chemical binding]; other site 592316014427 putative dimerization interface [polypeptide binding]; other site 592316014428 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 592316014429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316014430 Walker A/P-loop; other site 592316014431 ATP binding site [chemical binding]; other site 592316014432 Q-loop/lid; other site 592316014433 ABC transporter signature motif; other site 592316014434 Walker B; other site 592316014435 D-loop; other site 592316014436 H-loop/switch region; other site 592316014437 TOBE domain; Region: TOBE_2; pfam08402 592316014438 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 592316014439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316014440 dimer interface [polypeptide binding]; other site 592316014441 conserved gate region; other site 592316014442 putative PBP binding loops; other site 592316014443 ABC-ATPase subunit interface; other site 592316014444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316014445 dimer interface [polypeptide binding]; other site 592316014446 conserved gate region; other site 592316014447 putative PBP binding loops; other site 592316014448 ABC-ATPase subunit interface; other site 592316014449 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 592316014450 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 592316014451 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 592316014452 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 592316014453 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 592316014454 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 592316014455 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316014456 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316014457 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 592316014458 putative substrate binding pocket [chemical binding]; other site 592316014459 dimerization interface [polypeptide binding]; other site 592316014460 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592316014461 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 592316014462 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 592316014463 homotrimer interaction site [polypeptide binding]; other site 592316014464 putative active site [active] 592316014465 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 592316014466 acetylornithine deacetylase; Provisional; Region: PRK07522 592316014467 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 592316014468 metal binding site [ion binding]; metal-binding site 592316014469 putative dimer interface [polypeptide binding]; other site 592316014470 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592316014471 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316014472 DNA binding site [nucleotide binding] 592316014473 domain linker motif; other site 592316014474 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 592316014475 putative dimerization interface [polypeptide binding]; other site 592316014476 putative ligand binding site [chemical binding]; other site 592316014477 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 592316014478 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 592316014479 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 592316014480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316014481 dimer interface [polypeptide binding]; other site 592316014482 conserved gate region; other site 592316014483 putative PBP binding loops; other site 592316014484 ABC-ATPase subunit interface; other site 592316014485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316014486 dimer interface [polypeptide binding]; other site 592316014487 conserved gate region; other site 592316014488 putative PBP binding loops; other site 592316014489 ABC-ATPase subunit interface; other site 592316014490 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 592316014491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316014492 Walker A/P-loop; other site 592316014493 ATP binding site [chemical binding]; other site 592316014494 Q-loop/lid; other site 592316014495 ABC transporter signature motif; other site 592316014496 Walker B; other site 592316014497 D-loop; other site 592316014498 H-loop/switch region; other site 592316014499 TOBE domain; Region: TOBE_2; pfam08402 592316014500 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 592316014501 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 592316014502 active site 592316014503 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 592316014504 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316014505 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592316014506 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316014507 LysE type translocator; Region: LysE; cl00565 592316014508 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 592316014509 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 592316014510 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 592316014511 TM-ABC transporter signature motif; other site 592316014512 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 592316014513 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 592316014514 TM-ABC transporter signature motif; other site 592316014515 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 592316014516 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 592316014517 Walker A/P-loop; other site 592316014518 ATP binding site [chemical binding]; other site 592316014519 Q-loop/lid; other site 592316014520 ABC transporter signature motif; other site 592316014521 Walker B; other site 592316014522 D-loop; other site 592316014523 H-loop/switch region; other site 592316014524 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 592316014525 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 592316014526 Walker A/P-loop; other site 592316014527 ATP binding site [chemical binding]; other site 592316014528 Q-loop/lid; other site 592316014529 ABC transporter signature motif; other site 592316014530 Walker B; other site 592316014531 D-loop; other site 592316014532 H-loop/switch region; other site 592316014533 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 592316014534 ANTAR domain; Region: ANTAR; pfam03861 592316014535 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592316014536 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316014537 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 592316014538 Amidase; Region: Amidase; pfam01425 592316014539 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 592316014540 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316014541 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316014542 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316014543 dimerization interface [polypeptide binding]; other site 592316014544 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316014545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316014546 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316014547 dimerization interface [polypeptide binding]; other site 592316014548 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 592316014549 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 592316014550 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 592316014551 active site 592316014552 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 592316014553 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 592316014554 active site 592316014555 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 592316014556 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 592316014557 active site 592316014558 non-prolyl cis peptide bond; other site 592316014559 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 592316014560 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 592316014561 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 592316014562 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 592316014563 Walker A/P-loop; other site 592316014564 ATP binding site [chemical binding]; other site 592316014565 Q-loop/lid; other site 592316014566 ABC transporter signature motif; other site 592316014567 Walker B; other site 592316014568 D-loop; other site 592316014569 H-loop/switch region; other site 592316014570 NIL domain; Region: NIL; pfam09383 592316014571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316014572 dimer interface [polypeptide binding]; other site 592316014573 conserved gate region; other site 592316014574 ABC-ATPase subunit interface; other site 592316014575 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316014576 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316014577 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 592316014578 putative effector binding pocket; other site 592316014579 putative dimerization interface [polypeptide binding]; other site 592316014580 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 592316014581 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 592316014582 NAD(P) binding site [chemical binding]; other site 592316014583 active site 592316014584 Hok/gef family; Region: HOK_GEF; pfam01848 592316014585 RNA polymerase sigma factor; Provisional; Region: PRK12512 592316014586 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592316014587 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592316014588 DNA binding residues [nucleotide binding] 592316014589 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 592316014590 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 592316014591 DsbD alpha interface [polypeptide binding]; other site 592316014592 catalytic residues [active] 592316014593 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 592316014594 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 592316014595 catalytic triad [active] 592316014596 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 592316014597 HipA-like C-terminal domain; Region: HipA_C; pfam07804 592316014598 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316014599 non-specific DNA binding site [nucleotide binding]; other site 592316014600 salt bridge; other site 592316014601 sequence-specific DNA binding site [nucleotide binding]; other site 592316014602 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 592316014603 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 592316014604 carboxyltransferase (CT) interaction site; other site 592316014605 biotinylation site [posttranslational modification]; other site 592316014606 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 592316014607 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 592316014608 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 592316014609 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 592316014610 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 592316014611 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 592316014612 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 592316014613 NAD(P) binding site [chemical binding]; other site 592316014614 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 592316014615 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 592316014616 trimer interface [polypeptide binding]; other site 592316014617 eyelet of channel; other site 592316014618 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 592316014619 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316014620 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 592316014621 putative dimerization interface [polypeptide binding]; other site 592316014622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316014623 dimer interface [polypeptide binding]; other site 592316014624 conserved gate region; other site 592316014625 putative PBP binding loops; other site 592316014626 ABC-ATPase subunit interface; other site 592316014627 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 592316014628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316014629 dimer interface [polypeptide binding]; other site 592316014630 conserved gate region; other site 592316014631 putative PBP binding loops; other site 592316014632 ABC-ATPase subunit interface; other site 592316014633 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 592316014634 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 592316014635 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 592316014636 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316014637 Walker A/P-loop; other site 592316014638 ATP binding site [chemical binding]; other site 592316014639 Q-loop/lid; other site 592316014640 ABC transporter signature motif; other site 592316014641 Walker B; other site 592316014642 D-loop; other site 592316014643 H-loop/switch region; other site 592316014644 TOBE domain; Region: TOBE_2; pfam08402 592316014645 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 592316014646 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316014647 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 592316014648 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 592316014649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316014650 putative substrate translocation pore; other site 592316014651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316014652 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 592316014653 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 592316014654 active site 592316014655 putative substrate binding pocket [chemical binding]; other site 592316014656 amidohydrolase; Provisional; Region: PRK12393 592316014657 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 592316014658 active site 592316014659 putative substrate binding pocket [chemical binding]; other site 592316014660 NMT1/THI5 like; Region: NMT1; pfam09084 592316014661 oxidase reductase; Provisional; Region: PTZ00273 592316014662 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 592316014663 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 592316014664 NlpC/P60 family; Region: NLPC_P60; pfam00877 592316014665 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592316014666 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316014667 metal binding site [ion binding]; metal-binding site 592316014668 active site 592316014669 I-site; other site 592316014670 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 592316014671 Mechanosensitive ion channel; Region: MS_channel; pfam00924 592316014672 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 592316014673 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14254 592316014674 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 592316014675 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592316014676 FeS/SAM binding site; other site 592316014677 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 592316014678 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 592316014679 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316014680 motif II; other site 592316014681 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 592316014682 Sulfatase; Region: Sulfatase; pfam00884 592316014683 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 592316014684 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 592316014685 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 592316014686 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 592316014687 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316014688 N-terminal plug; other site 592316014689 ligand-binding site [chemical binding]; other site 592316014690 PQQ-like domain; Region: PQQ_2; pfam13360 592316014691 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 592316014692 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 592316014693 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 592316014694 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 592316014695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316014696 putative substrate translocation pore; other site 592316014697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316014698 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 592316014699 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316014700 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592316014701 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316014702 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 592316014703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316014704 putative substrate translocation pore; other site 592316014705 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592316014706 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592316014707 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592316014708 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 592316014709 active site 592316014710 phosphorylation site [posttranslational modification] 592316014711 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 592316014712 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 592316014713 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 592316014714 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 592316014715 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 592316014716 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316014717 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316014718 Cytochrome c; Region: Cytochrom_C; pfam00034 592316014719 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 592316014720 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 592316014721 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592316014722 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 592316014723 Cytochrome c; Region: Cytochrom_C; pfam00034 592316014724 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316014725 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316014726 Cytochrome c; Region: Cytochrom_C; pfam00034 592316014727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592316014728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316014729 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 592316014730 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 592316014731 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 592316014732 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 592316014733 Pectate lyase; Region: Pectate_lyase; pfam03211 592316014734 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 592316014735 binding surface 592316014736 TPR motif; other site 592316014737 Tetratricopeptide repeat; Region: TPR_16; pfam13432 592316014738 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 592316014739 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592316014740 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592316014741 DNA binding residues [nucleotide binding] 592316014742 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 592316014743 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592316014744 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 592316014745 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 592316014746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316014747 D-galactonate transporter; Region: 2A0114; TIGR00893 592316014748 putative substrate translocation pore; other site 592316014749 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 592316014750 Amidinotransferase; Region: Amidinotransf; cl12043 592316014751 MarR family; Region: MarR_2; pfam12802 592316014752 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316014753 Coenzyme A binding pocket [chemical binding]; other site 592316014754 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 592316014755 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 592316014756 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 592316014757 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 592316014758 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 592316014759 dimer interface [polypeptide binding]; other site 592316014760 ADP-ribose binding site [chemical binding]; other site 592316014761 active site 592316014762 nudix motif; other site 592316014763 metal binding site [ion binding]; metal-binding site 592316014764 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 592316014765 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 592316014766 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592316014767 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 592316014768 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 592316014769 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 592316014770 putative NAD(P) binding site [chemical binding]; other site 592316014771 putative active site [active] 592316014772 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316014773 DNA-binding site [nucleotide binding]; DNA binding site 592316014774 Transcriptional regulators [Transcription]; Region: GntR; COG1802 592316014775 Transcriptional regulators [Transcription]; Region: GntR; COG1802 592316014776 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 592316014777 FCD domain; Region: FCD; pfam07729 592316014778 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316014779 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316014780 substrate binding pocket [chemical binding]; other site 592316014781 membrane-bound complex binding site; other site 592316014782 hinge residues; other site 592316014783 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316014784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316014785 dimer interface [polypeptide binding]; other site 592316014786 conserved gate region; other site 592316014787 putative PBP binding loops; other site 592316014788 ABC-ATPase subunit interface; other site 592316014789 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316014790 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316014791 Walker A/P-loop; other site 592316014792 ATP binding site [chemical binding]; other site 592316014793 Q-loop/lid; other site 592316014794 ABC transporter signature motif; other site 592316014795 Walker B; other site 592316014796 D-loop; other site 592316014797 H-loop/switch region; other site 592316014798 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 592316014799 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 592316014800 metal binding site [ion binding]; metal-binding site 592316014801 dimer interface [polypeptide binding]; other site 592316014802 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 592316014803 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 592316014804 metal binding site [ion binding]; metal-binding site 592316014805 substrate binding pocket [chemical binding]; other site 592316014806 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 592316014807 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 592316014808 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 592316014809 active site 592316014810 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 592316014811 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 592316014812 inhibitor site; inhibition site 592316014813 active site 592316014814 dimer interface [polypeptide binding]; other site 592316014815 catalytic residue [active] 592316014816 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 592316014817 conserved cys residue [active] 592316014818 aspartate aminotransferase; Provisional; Region: PRK05764 592316014819 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316014820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316014821 homodimer interface [polypeptide binding]; other site 592316014822 catalytic residue [active] 592316014823 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 592316014824 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 592316014825 NAD binding site [chemical binding]; other site 592316014826 catalytic Zn binding site [ion binding]; other site 592316014827 structural Zn binding site [ion binding]; other site 592316014828 short chain dehydrogenase; Provisional; Region: PRK06180 592316014829 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 592316014830 NADP binding site [chemical binding]; other site 592316014831 active site 592316014832 steroid binding site; other site 592316014833 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 592316014834 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 592316014835 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 592316014836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316014837 Coenzyme A binding pocket [chemical binding]; other site 592316014838 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 592316014839 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 592316014840 metal binding site [ion binding]; metal-binding site 592316014841 dimer interface [polypeptide binding]; other site 592316014842 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 592316014843 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 592316014844 active site 592316014845 substrate binding pocket [chemical binding]; other site 592316014846 homodimer interaction site [polypeptide binding]; other site 592316014847 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316014848 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592316014849 TM-ABC transporter signature motif; other site 592316014850 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 592316014851 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 592316014852 Walker A/P-loop; other site 592316014853 ATP binding site [chemical binding]; other site 592316014854 Q-loop/lid; other site 592316014855 ABC transporter signature motif; other site 592316014856 Walker B; other site 592316014857 D-loop; other site 592316014858 H-loop/switch region; other site 592316014859 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592316014860 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316014861 DNA binding site [nucleotide binding] 592316014862 domain linker motif; other site 592316014863 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_11; cd06293 592316014864 putative dimerization interface [polypeptide binding]; other site 592316014865 putative ligand binding site [chemical binding]; other site 592316014866 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 592316014867 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 592316014868 ligand binding site [chemical binding]; other site 592316014869 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592316014870 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 592316014871 substrate binding site [chemical binding]; other site 592316014872 dimer interface [polypeptide binding]; other site 592316014873 ATP binding site [chemical binding]; other site 592316014874 BtpA family; Region: BtpA; cl00440 592316014875 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 592316014876 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 592316014877 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316014878 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316014879 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316014880 dimerization interface [polypeptide binding]; other site 592316014881 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 592316014882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316014883 Coenzyme A binding pocket [chemical binding]; other site 592316014884 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316014885 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316014886 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592316014887 dimerization interface [polypeptide binding]; other site 592316014888 Fusaric acid resistance protein family; Region: FUSC; pfam04632 592316014889 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 592316014890 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 592316014891 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 592316014892 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 592316014893 putative ligand binding residues [chemical binding]; other site 592316014894 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 592316014895 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 592316014896 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316014897 N-terminal plug; other site 592316014898 ligand-binding site [chemical binding]; other site 592316014899 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 592316014900 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 592316014901 intersubunit interface [polypeptide binding]; other site 592316014902 Iron permease FTR1 family; Region: FTR1; cl00475 592316014903 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 592316014904 Imelysin; Region: Peptidase_M75; pfam09375 592316014905 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 592316014906 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 592316014907 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 592316014908 zinc/cadmium-binding protein; Provisional; Region: PRK10306 592316014909 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 592316014910 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 592316014911 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 592316014912 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 592316014913 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316014914 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316014915 Cytochrome c; Region: Cytochrom_C; pfam00034 592316014916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316014917 D-galactonate transporter; Region: 2A0114; TIGR00893 592316014918 putative substrate translocation pore; other site 592316014919 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 592316014920 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 592316014921 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 592316014922 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 592316014923 putative active site [active] 592316014924 putative metal binding site [ion binding]; other site 592316014925 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592316014926 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316014927 non-specific DNA binding site [nucleotide binding]; other site 592316014928 salt bridge; other site 592316014929 sequence-specific DNA binding site [nucleotide binding]; other site 592316014930 Cupin domain; Region: Cupin_2; cl17218 592316014931 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 592316014932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316014933 Coenzyme A binding pocket [chemical binding]; other site 592316014934 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 592316014935 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592316014936 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316014937 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316014938 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 592316014939 putative effector binding pocket; other site 592316014940 dimerization interface [polypeptide binding]; other site 592316014941 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 592316014942 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 592316014943 conserved cys residue [active] 592316014944 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316014945 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316014946 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 592316014947 Zn2+ binding site [ion binding]; other site 592316014948 Mg2+ binding site [ion binding]; other site 592316014949 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 592316014950 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 592316014951 Trp docking motif [polypeptide binding]; other site 592316014952 putative active site [active] 592316014953 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 592316014954 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 592316014955 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 592316014956 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 592316014957 metal binding site [ion binding]; metal-binding site 592316014958 putative dimer interface [polypeptide binding]; other site 592316014959 Transcriptional regulators [Transcription]; Region: GntR; COG1802 592316014960 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316014961 DNA-binding site [nucleotide binding]; DNA binding site 592316014962 FCD domain; Region: FCD; pfam07729 592316014963 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 592316014964 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 592316014965 ligand binding site [chemical binding]; other site 592316014966 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 592316014967 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316014968 TM-ABC transporter signature motif; other site 592316014969 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 592316014970 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 592316014971 TM-ABC transporter signature motif; other site 592316014972 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 592316014973 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 592316014974 Walker A/P-loop; other site 592316014975 ATP binding site [chemical binding]; other site 592316014976 Q-loop/lid; other site 592316014977 ABC transporter signature motif; other site 592316014978 Walker B; other site 592316014979 D-loop; other site 592316014980 H-loop/switch region; other site 592316014981 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 592316014982 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 592316014983 Walker A/P-loop; other site 592316014984 ATP binding site [chemical binding]; other site 592316014985 Q-loop/lid; other site 592316014986 ABC transporter signature motif; other site 592316014987 Walker B; other site 592316014988 D-loop; other site 592316014989 H-loop/switch region; other site 592316014990 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 592316014991 flagellar capping protein; Reviewed; Region: fliD; PRK08032 592316014992 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 592316014993 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 592316014994 Helix-turn-helix domain; Region: HTH_28; pfam13518 592316014995 Winged helix-turn helix; Region: HTH_29; pfam13551 592316014996 Homeodomain-like domain; Region: HTH_32; pfam13565 592316014997 Integrase core domain; Region: rve; pfam00665 592316014998 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 592316014999 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592316015000 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316015001 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 592316015002 transcriptional regulator MalT; Provisional; Region: PRK04841 592316015003 AAA ATPase domain; Region: AAA_16; pfam13191 592316015004 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592316015005 DNA binding residues [nucleotide binding] 592316015006 dimerization interface [polypeptide binding]; other site 592316015007 maltodextrin phosphorylase; Provisional; Region: PRK14985 592316015008 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 592316015009 active site pocket [active] 592316015010 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 592316015011 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 592316015012 maltose regulon periplasmic protein; Provisional; Region: PRK10564 592316015013 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 592316015014 trimer interface; other site 592316015015 sugar binding site [chemical binding]; other site 592316015016 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 592316015017 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 592316015018 Walker A/P-loop; other site 592316015019 ATP binding site [chemical binding]; other site 592316015020 Q-loop/lid; other site 592316015021 ABC transporter signature motif; other site 592316015022 Walker B; other site 592316015023 D-loop; other site 592316015024 H-loop/switch region; other site 592316015025 TOBE domain; Region: TOBE_2; pfam08402 592316015026 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 592316015027 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 592316015028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316015029 dimer interface [polypeptide binding]; other site 592316015030 conserved gate region; other site 592316015031 putative PBP binding loops; other site 592316015032 ABC-ATPase subunit interface; other site 592316015033 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 592316015034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316015035 dimer interface [polypeptide binding]; other site 592316015036 conserved gate region; other site 592316015037 putative PBP binding loops; other site 592316015038 ABC-ATPase subunit interface; other site 592316015039 HipA N-terminal domain; Region: Couple_hipA; pfam13657 592316015040 HipA-like N-terminal domain; Region: HipA_N; pfam07805 592316015041 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 592316015042 HipA-like C-terminal domain; Region: HipA_C; pfam07804 592316015043 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592316015044 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316015045 non-specific DNA binding site [nucleotide binding]; other site 592316015046 salt bridge; other site 592316015047 sequence-specific DNA binding site [nucleotide binding]; other site 592316015048 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 592316015049 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 592316015050 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 592316015051 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 592316015052 classical (c) SDRs; Region: SDR_c; cd05233 592316015053 NAD(P) binding site [chemical binding]; other site 592316015054 active site 592316015055 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 592316015056 classical (c) SDRs; Region: SDR_c; cd05233 592316015057 NAD(P) binding site [chemical binding]; other site 592316015058 active site 592316015059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316015060 benzoate transport; Region: 2A0115; TIGR00895 592316015061 putative substrate translocation pore; other site 592316015062 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 592316015063 active site 592316015064 catalytic site [active] 592316015065 Zn binding site [ion binding]; other site 592316015066 tetramer interface [polypeptide binding]; other site 592316015067 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 592316015068 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316015069 DNA-binding site [nucleotide binding]; DNA binding site 592316015070 Transcriptional regulators [Transcription]; Region: GntR; COG1802 592316015071 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 592316015072 DNA-binding site [nucleotide binding]; DNA binding site 592316015073 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 592316015074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316015075 metabolite-proton symporter; Region: 2A0106; TIGR00883 592316015076 putative substrate translocation pore; other site 592316015077 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 592316015078 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 592316015079 phosphate binding site [ion binding]; other site 592316015080 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 592316015081 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 592316015082 dimer interface [polypeptide binding]; other site 592316015083 active site 592316015084 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 592316015085 substrate binding site [chemical binding]; other site 592316015086 catalytic residue [active] 592316015087 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 592316015088 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 592316015089 tetramer interface [polypeptide binding]; other site 592316015090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316015091 catalytic residue [active] 592316015092 YheO-like PAS domain; Region: PAS_6; pfam08348 592316015093 HTH domain; Region: HTH_22; pfam13309 592316015094 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 592316015095 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 592316015096 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 592316015097 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 592316015098 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 592316015099 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 592316015100 putative active site [active] 592316015101 putative catalytic site [active] 592316015102 putative Zn binding site [ion binding]; other site 592316015103 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 592316015104 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 592316015105 active site 592316015106 substrate binding site [chemical binding]; other site 592316015107 cosubstrate binding site; other site 592316015108 catalytic site [active] 592316015109 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 592316015110 active site 592316015111 hexamer interface [polypeptide binding]; other site 592316015112 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 592316015113 NAD binding site [chemical binding]; other site 592316015114 substrate binding site [chemical binding]; other site 592316015115 active site 592316015116 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 592316015117 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 592316015118 Ligand binding site; other site 592316015119 Putative Catalytic site; other site 592316015120 DXD motif; other site 592316015121 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 592316015122 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 592316015123 inhibitor-cofactor binding pocket; inhibition site 592316015124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316015125 catalytic residue [active] 592316015126 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 592316015127 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 592316015128 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 592316015129 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 592316015130 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592316015131 inhibitor-cofactor binding pocket; inhibition site 592316015132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316015133 catalytic residue [active] 592316015134 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 592316015135 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316015136 catalytic residue [active] 592316015137 aspartate aminotransferase; Provisional; Region: PRK06108 592316015138 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316015139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316015140 homodimer interface [polypeptide binding]; other site 592316015141 catalytic residue [active] 592316015142 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316015143 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316015144 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 592316015145 putative effector binding pocket; other site 592316015146 putative dimerization interface [polypeptide binding]; other site 592316015147 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592316015148 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592316015149 active site 592316015150 catalytic tetrad [active] 592316015151 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592316015152 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 592316015153 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 592316015154 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 592316015155 RNA binding surface [nucleotide binding]; other site 592316015156 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 592316015157 probable active site [active] 592316015158 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 592316015159 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592316015160 dimerization interface [polypeptide binding]; other site 592316015161 putative DNA binding site [nucleotide binding]; other site 592316015162 putative Zn2+ binding site [ion binding]; other site 592316015163 AsnC family; Region: AsnC_trans_reg; pfam01037 592316015164 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 592316015165 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 592316015166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316015167 non-specific DNA binding site [nucleotide binding]; other site 592316015168 salt bridge; other site 592316015169 sequence-specific DNA binding site [nucleotide binding]; other site 592316015170 Cupin domain; Region: Cupin_2; pfam07883 592316015171 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 592316015172 B3/4 domain; Region: B3_4; pfam03483 592316015173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592316015174 Coenzyme A binding pocket [chemical binding]; other site 592316015175 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 592316015176 nudix motif; other site 592316015177 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 592316015178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316015179 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 592316015180 putative substrate translocation pore; other site 592316015181 MarR family; Region: MarR_2; cl17246 592316015182 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 592316015183 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 592316015184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316015185 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592316015186 Methyltransferase domain; Region: Methyltransf_23; pfam13489 592316015187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316015188 S-adenosylmethionine binding site [chemical binding]; other site 592316015189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 592316015190 Cache domain; Region: Cache_1; pfam02743 592316015191 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 592316015192 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592316015193 dimer interface [polypeptide binding]; other site 592316015194 putative CheW interface [polypeptide binding]; other site 592316015195 antitoxin YefM; Provisional; Region: PRK11409 592316015196 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 592316015197 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 592316015198 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316015199 Cytochrome c; Region: Cytochrom_C; pfam00034 592316015200 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 592316015201 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592316015202 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 592316015203 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 592316015204 Domain of unknown function (DUF336); Region: DUF336; pfam03928 592316015205 Predicted membrane protein [Function unknown]; Region: COG2259 592316015206 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 592316015207 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 592316015208 ligand binding site [chemical binding]; other site 592316015209 NAD binding site [chemical binding]; other site 592316015210 dimerization interface [polypeptide binding]; other site 592316015211 catalytic site [active] 592316015212 hypothetical protein; Validated; Region: PRK06201 592316015213 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 592316015214 benzoate transport; Region: 2A0115; TIGR00895 592316015215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316015216 putative substrate translocation pore; other site 592316015217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316015218 Acyltransferase family; Region: Acyl_transf_3; pfam01757 592316015219 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 592316015220 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592316015221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316015222 Walker A/P-loop; other site 592316015223 ATP binding site [chemical binding]; other site 592316015224 Q-loop/lid; other site 592316015225 ABC transporter signature motif; other site 592316015226 Walker B; other site 592316015227 D-loop; other site 592316015228 H-loop/switch region; other site 592316015229 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 592316015230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316015231 Walker A/P-loop; other site 592316015232 ATP binding site [chemical binding]; other site 592316015233 Q-loop/lid; other site 592316015234 ABC transporter signature motif; other site 592316015235 Walker B; other site 592316015236 D-loop; other site 592316015237 H-loop/switch region; other site 592316015238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316015239 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592316015240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316015241 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316015242 N-terminal plug; other site 592316015243 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 592316015244 ligand-binding site [chemical binding]; other site 592316015245 Fic family protein [Function unknown]; Region: COG3177 592316015246 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 592316015247 Fic/DOC family; Region: Fic; pfam02661 592316015248 YebG protein; Region: YebG; pfam07130 592316015249 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 592316015250 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 592316015251 active site 592316015252 dimerization interface [polypeptide binding]; other site 592316015253 Methyltransferase domain; Region: Methyltransf_23; pfam13489 592316015254 Methyltransferase domain; Region: Methyltransf_11; pfam08241 592316015255 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 592316015256 substrate binding pocket [chemical binding]; other site 592316015257 substrate-Mg2+ binding site; other site 592316015258 aspartate-rich region 1; other site 592316015259 aspartate-rich region 2; other site 592316015260 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 592316015261 Cytochrome P450; Region: p450; cl12078 592316015262 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316015263 Coenzyme A binding pocket [chemical binding]; other site 592316015264 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 592316015265 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 592316015266 active site 592316015267 non-prolyl cis peptide bond; other site 592316015268 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 592316015269 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 592316015270 metal binding site [ion binding]; metal-binding site 592316015271 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 592316015272 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 592316015273 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 592316015274 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 592316015275 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592316015276 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 592316015277 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316015278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316015279 dimer interface [polypeptide binding]; other site 592316015280 conserved gate region; other site 592316015281 ABC-ATPase subunit interface; other site 592316015282 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 592316015283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316015284 dimer interface [polypeptide binding]; other site 592316015285 conserved gate region; other site 592316015286 putative PBP binding loops; other site 592316015287 ABC-ATPase subunit interface; other site 592316015288 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 592316015289 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316015290 Walker A/P-loop; other site 592316015291 ATP binding site [chemical binding]; other site 592316015292 Q-loop/lid; other site 592316015293 ABC transporter signature motif; other site 592316015294 Walker B; other site 592316015295 D-loop; other site 592316015296 H-loop/switch region; other site 592316015297 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316015298 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316015299 Walker A/P-loop; other site 592316015300 ATP binding site [chemical binding]; other site 592316015301 Q-loop/lid; other site 592316015302 ABC transporter signature motif; other site 592316015303 Walker B; other site 592316015304 D-loop; other site 592316015305 H-loop/switch region; other site 592316015306 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316015307 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 592316015308 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 592316015309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 592316015310 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 592316015311 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 592316015312 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 592316015313 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 592316015314 metal binding site [ion binding]; metal-binding site 592316015315 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 592316015316 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 592316015317 hydrophobic ligand binding site; other site 592316015318 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 592316015319 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316015320 N-terminal plug; other site 592316015321 ligand-binding site [chemical binding]; other site 592316015322 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316015323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316015324 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316015325 dimerization interface [polypeptide binding]; other site 592316015326 Major royal jelly protein; Region: MRJP; pfam03022 592316015327 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 592316015328 Citrate transporter; Region: CitMHS; pfam03600 592316015329 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 592316015330 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 592316015331 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 592316015332 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 592316015333 potential catalytic triad [active] 592316015334 conserved cys residue [active] 592316015335 aspartate aminotransferase; Provisional; Region: PRK05764 592316015336 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316015337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316015338 homodimer interface [polypeptide binding]; other site 592316015339 catalytic residue [active] 592316015340 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 592316015341 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 592316015342 active site 592316015343 non-prolyl cis peptide bond; other site 592316015344 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 592316015345 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 592316015346 putative active site [active] 592316015347 metal binding site [ion binding]; metal-binding site 592316015348 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 592316015349 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 592316015350 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 592316015351 metal binding site [ion binding]; metal-binding site 592316015352 dimer interface [polypeptide binding]; other site 592316015353 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 592316015354 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 592316015355 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 592316015356 molybdopterin cofactor binding site [chemical binding]; other site 592316015357 substrate binding site [chemical binding]; other site 592316015358 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 592316015359 molybdopterin cofactor binding site; other site 592316015360 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316015361 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316015362 Walker A/P-loop; other site 592316015363 ATP binding site [chemical binding]; other site 592316015364 Q-loop/lid; other site 592316015365 ABC transporter signature motif; other site 592316015366 Walker B; other site 592316015367 D-loop; other site 592316015368 H-loop/switch region; other site 592316015369 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316015370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316015371 dimer interface [polypeptide binding]; other site 592316015372 conserved gate region; other site 592316015373 putative PBP binding loops; other site 592316015374 ABC-ATPase subunit interface; other site 592316015375 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316015376 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316015377 substrate binding pocket [chemical binding]; other site 592316015378 membrane-bound complex binding site; other site 592316015379 hinge residues; other site 592316015380 outer membrane receptor FepA; Provisional; Region: PRK13528 592316015381 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316015382 N-terminal plug; other site 592316015383 ligand-binding site [chemical binding]; other site 592316015384 Autoinducer binding domain; Region: Autoind_bind; pfam03472 592316015385 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592316015386 DNA binding residues [nucleotide binding] 592316015387 dimerization interface [polypeptide binding]; other site 592316015388 Autoinducer binding domain; Region: Autoind_bind; pfam03472 592316015389 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592316015390 DNA binding residues [nucleotide binding] 592316015391 dimerization interface [polypeptide binding]; other site 592316015392 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 592316015393 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 592316015394 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592316015395 catalytic residue [active] 592316015396 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316015397 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316015398 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 592316015399 putative dimerization interface [polypeptide binding]; other site 592316015400 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 592316015401 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592316015402 putative metal binding site [ion binding]; other site 592316015403 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316015404 DNA binding site [nucleotide binding] 592316015405 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 592316015406 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 592316015407 putative ligand binding site [chemical binding]; other site 592316015408 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 592316015409 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592316015410 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592316015411 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592316015412 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 592316015413 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592316015414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316015415 EamA-like transporter family; Region: EamA; pfam00892 592316015416 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 592316015417 EamA-like transporter family; Region: EamA; pfam00892 592316015418 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 592316015419 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 592316015420 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 592316015421 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 592316015422 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 592316015423 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 592316015424 intersubunit interface [polypeptide binding]; other site 592316015425 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 592316015426 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 592316015427 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 592316015428 catalytic site [active] 592316015429 active site 592316015430 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 592316015431 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 592316015432 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 592316015433 active site 592316015434 catalytic site [active] 592316015435 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 592316015436 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 592316015437 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 592316015438 active site 592316015439 catalytic site [active] 592316015440 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316015441 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316015442 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 592316015443 putative effector binding pocket; other site 592316015444 putative dimerization interface [polypeptide binding]; other site 592316015445 short chain dehydrogenase; Provisional; Region: PRK06500 592316015446 classical (c) SDRs; Region: SDR_c; cd05233 592316015447 NAD(P) binding site [chemical binding]; other site 592316015448 active site 592316015449 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 592316015450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316015451 NAD(P) binding site [chemical binding]; other site 592316015452 active site 592316015453 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 592316015454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316015455 D-galactonate transporter; Region: 2A0114; TIGR00893 592316015456 putative substrate translocation pore; other site 592316015457 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 592316015458 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 592316015459 phosphate binding site [ion binding]; other site 592316015460 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592316015461 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316015462 DNA binding site [nucleotide binding] 592316015463 domain linker motif; other site 592316015464 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 592316015465 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 592316015466 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 592316015467 TrkA-N domain; Region: TrkA_N; pfam02254 592316015468 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 592316015469 Cytochrome c; Region: Cytochrom_C; cl11414 592316015470 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316015471 Cytochrome c; Region: Cytochrom_C; pfam00034 592316015472 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316015473 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 592316015474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316015475 S-adenosylmethionine binding site [chemical binding]; other site 592316015476 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 592316015477 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 592316015478 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316015479 Walker A/P-loop; other site 592316015480 ATP binding site [chemical binding]; other site 592316015481 Q-loop/lid; other site 592316015482 ABC transporter signature motif; other site 592316015483 Walker B; other site 592316015484 D-loop; other site 592316015485 H-loop/switch region; other site 592316015486 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 592316015487 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 592316015488 substrate binding site [chemical binding]; other site 592316015489 cosubstrate binding site; other site 592316015490 catalytic site [active] 592316015491 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 592316015492 active site 592316015493 hexamer interface [polypeptide binding]; other site 592316015494 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 592316015495 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592316015496 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316015497 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 592316015498 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 592316015499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316015500 active site 592316015501 phosphorylation site [posttranslational modification] 592316015502 intermolecular recognition site; other site 592316015503 dimerization interface [polypeptide binding]; other site 592316015504 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592316015505 DNA binding site [nucleotide binding] 592316015506 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 592316015507 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592316015508 dimerization interface [polypeptide binding]; other site 592316015509 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316015510 dimer interface [polypeptide binding]; other site 592316015511 phosphorylation site [posttranslational modification] 592316015512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316015513 ATP binding site [chemical binding]; other site 592316015514 Mg2+ binding site [ion binding]; other site 592316015515 G-X-G motif; other site 592316015516 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 592316015517 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 592316015518 active site 592316015519 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 592316015520 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 592316015521 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 592316015522 Predicted membrane protein [Function unknown]; Region: COG1289 592316015523 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 592316015524 putative symporter YagG; Provisional; Region: PRK09669 592316015525 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 592316015526 alpha-glucosidase; Provisional; Region: PRK10426 592316015527 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 592316015528 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 592316015529 putative active site [active] 592316015530 putative catalytic site [active] 592316015531 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 592316015532 Autoinducer binding domain; Region: Autoind_bind; pfam03472 592316015533 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592316015534 DNA binding residues [nucleotide binding] 592316015535 dimerization interface [polypeptide binding]; other site 592316015536 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 592316015537 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 592316015538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 592316015539 hypothetical protein; Provisional; Region: PRK09262 592316015540 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 592316015541 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316015542 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316015543 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 592316015544 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316015545 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 592316015546 putative dimerization interface [polypeptide binding]; other site 592316015547 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 592316015548 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 592316015549 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 592316015550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316015551 Walker A motif; other site 592316015552 ATP binding site [chemical binding]; other site 592316015553 Walker B motif; other site 592316015554 arginine finger; other site 592316015555 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 592316015556 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 592316015557 dimerization interface [polypeptide binding]; other site 592316015558 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 592316015559 ATP binding site [chemical binding]; other site 592316015560 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 592316015561 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 592316015562 HupF/HypC family; Region: HupF_HypC; cl00394 592316015563 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 592316015564 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 592316015565 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 592316015566 Transcriptional repressor of hyc and hyp operons; Region: HycA_repressor; cl08095 592316015567 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 592316015568 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 592316015569 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 592316015570 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 592316015571 NADH dehydrogenase; Region: NADHdh; cl00469 592316015572 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 592316015573 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 592316015574 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 592316015575 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 592316015576 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 592316015577 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 592316015578 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 592316015579 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 592316015580 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 592316015581 nickel binding site [ion binding]; other site 592316015582 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 592316015583 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 592316015584 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 592316015585 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 592316015586 [4Fe-4S] binding site [ion binding]; other site 592316015587 molybdopterin cofactor binding site; other site 592316015588 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 592316015589 molybdopterin cofactor binding site; other site 592316015590 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 592316015591 Acylphosphatase; Region: Acylphosphatase; pfam00708 592316015592 HypF finger; Region: zf-HYPF; pfam07503 592316015593 HypF finger; Region: zf-HYPF; pfam07503 592316015594 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 592316015595 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 592316015596 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 592316015597 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 592316015598 TrkA-N domain; Region: TrkA_N; pfam02254 592316015599 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 592316015600 Cytochrome c; Region: Cytochrom_C; pfam00034 592316015601 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316015602 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316015603 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 592316015604 hybrid cluster protein; Provisional; Region: PRK05290 592316015605 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 592316015606 ACS interaction site; other site 592316015607 CODH interaction site; other site 592316015608 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 592316015609 ACS interaction site; other site 592316015610 CODH interaction site; other site 592316015611 metal cluster binding site [ion binding]; other site 592316015612 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 592316015613 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 592316015614 FAD binding pocket [chemical binding]; other site 592316015615 FAD binding motif [chemical binding]; other site 592316015616 phosphate binding motif [ion binding]; other site 592316015617 beta-alpha-beta structure motif; other site 592316015618 NAD binding pocket [chemical binding]; other site 592316015619 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 592316015620 catalytic loop [active] 592316015621 iron binding site [ion binding]; other site 592316015622 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 592316015623 Transcriptional regulator [Transcription]; Region: IclR; COG1414 592316015624 Bacterial transcriptional regulator; Region: IclR; pfam01614 592316015625 succinic semialdehyde dehydrogenase; Region: PLN02278 592316015626 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 592316015627 tetramerization interface [polypeptide binding]; other site 592316015628 NAD(P) binding site [chemical binding]; other site 592316015629 catalytic residues [active] 592316015630 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 592316015631 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 592316015632 putative active site [active] 592316015633 metal binding site [ion binding]; metal-binding site 592316015634 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 592316015635 benzoate transport; Region: 2A0115; TIGR00895 592316015636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316015637 putative substrate translocation pore; other site 592316015638 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 592316015639 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 592316015640 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 592316015641 metal binding site [ion binding]; metal-binding site 592316015642 putative dimer interface [polypeptide binding]; other site 592316015643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316015644 metabolite-proton symporter; Region: 2A0106; TIGR00883 592316015645 putative substrate translocation pore; other site 592316015646 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 592316015647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316015648 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316015649 dimerization interface [polypeptide binding]; other site 592316015650 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 592316015651 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 592316015652 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 592316015653 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 592316015654 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 592316015655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316015656 motif II; other site 592316015657 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 592316015658 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 592316015659 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316015660 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 592316015661 Protein export membrane protein; Region: SecD_SecF; cl14618 592316015662 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 592316015663 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 592316015664 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 592316015665 SET domain; Region: SET; pfam00856 592316015666 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 592316015667 putative active site pocket [active] 592316015668 dimerization interface [polypeptide binding]; other site 592316015669 putative catalytic residue [active] 592316015670 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592316015671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316015672 active site 592316015673 phosphorylation site [posttranslational modification] 592316015674 intermolecular recognition site; other site 592316015675 dimerization interface [polypeptide binding]; other site 592316015676 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 592316015677 DNA binding site [nucleotide binding] 592316015678 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 592316015679 HAMP domain; Region: HAMP; pfam00672 592316015680 dimerization interface [polypeptide binding]; other site 592316015681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316015682 dimer interface [polypeptide binding]; other site 592316015683 phosphorylation site [posttranslational modification] 592316015684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316015685 ATP binding site [chemical binding]; other site 592316015686 Mg2+ binding site [ion binding]; other site 592316015687 G-X-G motif; other site 592316015688 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 592316015689 putative outer membrane receptor; Provisional; Region: PRK13513 592316015690 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316015691 N-terminal plug; other site 592316015692 ligand-binding site [chemical binding]; other site 592316015693 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 592316015694 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 592316015695 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316015696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316015697 dimer interface [polypeptide binding]; other site 592316015698 conserved gate region; other site 592316015699 putative PBP binding loops; other site 592316015700 ABC-ATPase subunit interface; other site 592316015701 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 592316015702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316015703 dimer interface [polypeptide binding]; other site 592316015704 conserved gate region; other site 592316015705 putative PBP binding loops; other site 592316015706 ABC-ATPase subunit interface; other site 592316015707 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 592316015708 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316015709 Walker A/P-loop; other site 592316015710 ATP binding site [chemical binding]; other site 592316015711 Q-loop/lid; other site 592316015712 ABC transporter signature motif; other site 592316015713 Walker B; other site 592316015714 D-loop; other site 592316015715 H-loop/switch region; other site 592316015716 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316015717 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316015718 Walker A/P-loop; other site 592316015719 ATP binding site [chemical binding]; other site 592316015720 Q-loop/lid; other site 592316015721 ABC transporter signature motif; other site 592316015722 Walker B; other site 592316015723 D-loop; other site 592316015724 H-loop/switch region; other site 592316015725 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316015726 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592316015727 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 592316015728 peptide binding site [polypeptide binding]; other site 592316015729 hypothetical protein; Provisional; Region: PRK01346 592316015730 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 592316015731 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 592316015732 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 592316015733 active site 592316015734 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 592316015735 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 592316015736 active site 592316015737 dimer interface [polypeptide binding]; other site 592316015738 non-prolyl cis peptide bond; other site 592316015739 insertion regions; other site 592316015740 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 592316015741 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 592316015742 active site 592316015743 non-prolyl cis peptide bond; other site 592316015744 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 592316015745 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316015746 Walker A/P-loop; other site 592316015747 ATP binding site [chemical binding]; other site 592316015748 Q-loop/lid; other site 592316015749 ABC transporter signature motif; other site 592316015750 Walker B; other site 592316015751 D-loop; other site 592316015752 H-loop/switch region; other site 592316015753 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 592316015754 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316015755 Walker A/P-loop; other site 592316015756 ATP binding site [chemical binding]; other site 592316015757 Q-loop/lid; other site 592316015758 ABC transporter signature motif; other site 592316015759 Walker B; other site 592316015760 D-loop; other site 592316015761 H-loop/switch region; other site 592316015762 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 592316015763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316015764 dimer interface [polypeptide binding]; other site 592316015765 conserved gate region; other site 592316015766 putative PBP binding loops; other site 592316015767 ABC-ATPase subunit interface; other site 592316015768 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316015769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316015770 dimer interface [polypeptide binding]; other site 592316015771 conserved gate region; other site 592316015772 putative PBP binding loops; other site 592316015773 ABC-ATPase subunit interface; other site 592316015774 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 592316015775 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 592316015776 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 592316015777 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 592316015778 active site 592316015779 non-prolyl cis peptide bond; other site 592316015780 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 592316015781 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316015782 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316015783 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316015784 dimerization interface [polypeptide binding]; other site 592316015785 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 592316015786 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 592316015787 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 592316015788 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 592316015789 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 592316015790 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 592316015791 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 592316015792 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 592316015793 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 592316015794 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 592316015795 Coenzyme A transferase; Region: CoA_trans; cl17247 592316015796 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 592316015797 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 592316015798 active site 592316015799 FMN binding site [chemical binding]; other site 592316015800 substrate binding site [chemical binding]; other site 592316015801 putative catalytic residue [active] 592316015802 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592316015803 putative transporter; Provisional; Region: PRK10484 592316015804 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 592316015805 Na binding site [ion binding]; other site 592316015806 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 592316015807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316015808 NAD(P) binding site [chemical binding]; other site 592316015809 active site 592316015810 aspartate aminotransferase; Provisional; Region: PRK05764 592316015811 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316015812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316015813 homodimer interface [polypeptide binding]; other site 592316015814 catalytic residue [active] 592316015815 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 592316015816 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 592316015817 ligand binding site [chemical binding]; other site 592316015818 flexible hinge region; other site 592316015819 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 592316015820 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 592316015821 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 592316015822 nucleoside/Zn binding site; other site 592316015823 dimer interface [polypeptide binding]; other site 592316015824 catalytic motif [active] 592316015825 xanthine permease; Region: pbuX; TIGR03173 592316015826 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316015827 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316015828 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592316015829 dimerization interface [polypeptide binding]; other site 592316015830 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 592316015831 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 592316015832 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 592316015833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316015834 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 592316015835 dimerization interface [polypeptide binding]; other site 592316015836 substrate binding pocket [chemical binding]; other site 592316015837 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 592316015838 GAF domain; Region: GAF; pfam01590 592316015839 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592316015840 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316015841 metal binding site [ion binding]; metal-binding site 592316015842 active site 592316015843 I-site; other site 592316015844 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592316015845 oxidoreductase; Provisional; Region: PRK12742 592316015846 classical (c) SDRs; Region: SDR_c; cd05233 592316015847 NAD(P) binding site [chemical binding]; other site 592316015848 active site 592316015849 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 592316015850 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 592316015851 active site 592316015852 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 592316015853 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316015854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316015855 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592316015856 dimerization interface [polypeptide binding]; other site 592316015857 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 592316015858 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 592316015859 [2Fe-2S] cluster binding site [ion binding]; other site 592316015860 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 592316015861 hydrophobic ligand binding site; other site 592316015862 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 592316015863 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 592316015864 FMN-binding pocket [chemical binding]; other site 592316015865 flavin binding motif; other site 592316015866 phosphate binding motif [ion binding]; other site 592316015867 beta-alpha-beta structure motif; other site 592316015868 NAD binding pocket [chemical binding]; other site 592316015869 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 592316015870 catalytic loop [active] 592316015871 iron binding site [ion binding]; other site 592316015872 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 592316015873 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 592316015874 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316015875 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316015876 dimerization interface [polypeptide binding]; other site 592316015877 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 592316015878 nudix motif; other site 592316015879 General stress protein [General function prediction only]; Region: GsiB; COG3729 592316015880 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316015881 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316015882 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 592316015883 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 592316015884 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 592316015885 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 592316015886 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 592316015887 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316015888 DNA binding site [nucleotide binding] 592316015889 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 592316015890 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 592316015891 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 592316015892 MASE2 domain; Region: MASE2; pfam05230 592316015893 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316015894 metal binding site [ion binding]; metal-binding site 592316015895 active site 592316015896 I-site; other site 592316015897 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 592316015898 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592316015899 dimerization interface [polypeptide binding]; other site 592316015900 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592316015901 dimer interface [polypeptide binding]; other site 592316015902 putative CheW interface [polypeptide binding]; other site 592316015903 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 592316015904 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 592316015905 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 592316015906 dimer interface [polypeptide binding]; other site 592316015907 active site 592316015908 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 592316015909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316015910 putative substrate translocation pore; other site 592316015911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316015912 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 592316015913 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592316015914 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316015915 Predicted transcriptional regulators [Transcription]; Region: COG1733 592316015916 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 592316015917 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 592316015918 active site 592316015919 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592316015920 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316015921 DNA binding site [nucleotide binding] 592316015922 domain linker motif; other site 592316015923 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 592316015924 dimerization interface (closed form) [polypeptide binding]; other site 592316015925 ligand binding site [chemical binding]; other site 592316015926 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 592316015927 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 592316015928 active site turn [active] 592316015929 phosphorylation site [posttranslational modification] 592316015930 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 592316015931 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 592316015932 beta-galactosidase; Region: BGL; TIGR03356 592316015933 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 592316015934 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 592316015935 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 592316015936 putative NAD(P) binding site [chemical binding]; other site 592316015937 putative substrate binding site [chemical binding]; other site 592316015938 catalytic Zn binding site [ion binding]; other site 592316015939 structural Zn binding site [ion binding]; other site 592316015940 dimer interface [polypeptide binding]; other site 592316015941 Predicted transcriptional regulators [Transcription]; Region: COG1733 592316015942 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 592316015943 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592316015944 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316015945 salt bridge; other site 592316015946 non-specific DNA binding site [nucleotide binding]; other site 592316015947 sequence-specific DNA binding site [nucleotide binding]; other site 592316015948 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 592316015949 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 592316015950 putative NAD(P) binding site [chemical binding]; other site 592316015951 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 592316015952 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316015953 active site 592316015954 motif I; other site 592316015955 motif II; other site 592316015956 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316015957 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592316015958 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316015959 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 592316015960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316015961 S-adenosylmethionine binding site [chemical binding]; other site 592316015962 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316015963 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316015964 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 592316015965 putative effector binding pocket; other site 592316015966 dimerization interface [polypeptide binding]; other site 592316015967 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 592316015968 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 592316015969 NAD(P) binding site [chemical binding]; other site 592316015970 active site 592316015971 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316015972 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316015973 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316015974 dimerization interface [polypeptide binding]; other site 592316015975 glutamate carboxypeptidase; Reviewed; Region: PRK06133 592316015976 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 592316015977 metal binding site [ion binding]; metal-binding site 592316015978 dimer interface [polypeptide binding]; other site 592316015979 Predicted membrane protein [Function unknown]; Region: COG1288 592316015980 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 592316015981 type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759 592316015982 F sex factor protein N terminal; Region: TraD_N; pfam12615 592316015983 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 592316015984 Walker A motif; other site 592316015985 ATP binding site [chemical binding]; other site 592316015986 Walker B motif; other site 592316015987 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 592316015988 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 592316015989 AAA domain; Region: AAA_30; pfam13604 592316015990 DNA helicase TraI; Region: TraI; pfam07057 592316015991 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592316015992 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 592316015993 active site 592316015994 metal binding site [ion binding]; metal-binding site 592316015995 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 592316015996 Helix-turn-helix domain; Region: HTH_38; pfam13936 592316015997 Homeodomain-like domain; Region: HTH_32; pfam13565 592316015998 Integrase core domain; Region: rve; pfam00665 592316015999 Winged helix-turn helix; Region: HTH_29; pfam13551 592316016000 Helix-turn-helix domain; Region: HTH_28; pfam13518 592316016001 Homeodomain-like domain; Region: HTH_32; pfam13565 592316016002 Integrase core domain; Region: rve; pfam00665 592316016003 Helix-turn-helix domain; Region: HTH_28; pfam13518 592316016004 Winged helix-turn helix; Region: HTH_29; pfam13551 592316016005 Homeodomain-like domain; Region: HTH_32; pfam13565 592316016006 Integrase core domain; Region: rve; pfam00665 592316016007 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 592316016008 putative transposase OrfB; Reviewed; Region: PHA02517 592316016009 HTH-like domain; Region: HTH_21; pfam13276 592316016010 Integrase core domain; Region: rve; pfam00665 592316016011 Integrase core domain; Region: rve_2; pfam13333 592316016012 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316016013 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316016014 LysR substrate binding domain; Region: LysR_substrate; pfam03466 592316016015 dimerization interface [polypeptide binding]; other site 592316016016 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316016017 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316016018 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 592316016019 putative effector binding pocket; other site 592316016020 dimerization interface [polypeptide binding]; other site 592316016021 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 592316016022 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 592316016023 FMN-binding pocket [chemical binding]; other site 592316016024 flavin binding motif; other site 592316016025 phosphate binding motif [ion binding]; other site 592316016026 beta-alpha-beta structure motif; other site 592316016027 NAD binding pocket [chemical binding]; other site 592316016028 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 592316016029 catalytic loop [active] 592316016030 iron binding site [ion binding]; other site 592316016031 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 592316016032 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 592316016033 [2Fe-2S] cluster binding site [ion binding]; other site 592316016034 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 592316016035 hydrophobic ligand binding site; other site 592316016036 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 592316016037 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 592316016038 [2Fe-2S] cluster binding site [ion binding]; other site 592316016039 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 592316016040 hydrophobic ligand binding site; other site 592316016041 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 592316016042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 592316016043 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 592316016044 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 592316016045 Walker A/P-loop; other site 592316016046 ATP binding site [chemical binding]; other site 592316016047 Q-loop/lid; other site 592316016048 ABC transporter signature motif; other site 592316016049 Walker B; other site 592316016050 D-loop; other site 592316016051 H-loop/switch region; other site 592316016052 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 592316016053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316016054 dimer interface [polypeptide binding]; other site 592316016055 conserved gate region; other site 592316016056 putative PBP binding loops; other site 592316016057 ABC-ATPase subunit interface; other site 592316016058 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 592316016059 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316016060 membrane-bound complex binding site; other site 592316016061 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 592316016062 Cupin domain; Region: Cupin_2; cl17218 592316016063 hypothetical protein; Provisional; Region: PRK07236 592316016064 hypothetical protein; Provisional; Region: PRK06753 592316016065 Isochorismatase family; Region: Isochorismatase; pfam00857 592316016066 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 592316016067 catalytic triad [active] 592316016068 conserved cis-peptide bond; other site 592316016069 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 592316016070 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316016071 Helix-turn-helix domain; Region: HTH_18; pfam12833 592316016072 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316016073 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 592316016074 EamA-like transporter family; Region: EamA; pfam00892 592316016075 EamA-like transporter family; Region: EamA; pfam00892 592316016076 Predicted amidohydrolase [General function prediction only]; Region: COG0388 592316016077 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 592316016078 putative active site [active] 592316016079 catalytic triad [active] 592316016080 putative dimer interface [polypeptide binding]; other site 592316016081 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 592316016082 EamA-like transporter family; Region: EamA; pfam00892 592316016083 Isochorismatase family; Region: Isochorismatase; pfam00857 592316016084 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 592316016085 catalytic triad [active] 592316016086 conserved cis-peptide bond; other site 592316016087 serine hydroxymethyltransferase; Region: PLN02271 592316016088 Cytochrome P450; Region: p450; cl12078 592316016089 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 592316016090 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 592316016091 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592316016092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316016093 Walker A/P-loop; other site 592316016094 ATP binding site [chemical binding]; other site 592316016095 Q-loop/lid; other site 592316016096 ABC transporter signature motif; other site 592316016097 Walker B; other site 592316016098 D-loop; other site 592316016099 H-loop/switch region; other site 592316016100 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 592316016101 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316016102 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 592316016103 Walker A/P-loop; other site 592316016104 ATP binding site [chemical binding]; other site 592316016105 Q-loop/lid; other site 592316016106 ABC transporter signature motif; other site 592316016107 Walker B; other site 592316016108 D-loop; other site 592316016109 H-loop/switch region; other site 592316016110 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 592316016111 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316016112 Walker A/P-loop; other site 592316016113 ATP binding site [chemical binding]; other site 592316016114 Q-loop/lid; other site 592316016115 ABC transporter signature motif; other site 592316016116 Walker B; other site 592316016117 D-loop; other site 592316016118 H-loop/switch region; other site 592316016119 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316016120 Walker A/P-loop; other site 592316016121 ATP binding site [chemical binding]; other site 592316016122 Q-loop/lid; other site 592316016123 ABC transporter signature motif; other site 592316016124 Walker B; other site 592316016125 D-loop; other site 592316016126 H-loop/switch region; other site 592316016127 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 592316016128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316016129 dimer interface [polypeptide binding]; other site 592316016130 ABC-ATPase subunit interface; other site 592316016131 putative PBP binding loops; other site 592316016132 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316016133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316016134 dimer interface [polypeptide binding]; other site 592316016135 conserved gate region; other site 592316016136 putative PBP binding loops; other site 592316016137 ABC-ATPase subunit interface; other site 592316016138 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592316016139 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 592316016140 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 592316016141 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316016142 N-terminal plug; other site 592316016143 ligand-binding site [chemical binding]; other site 592316016144 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592316016145 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316016146 salicylate synthase; Region: salicyl_syn; TIGR03494 592316016147 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 592316016148 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 592316016149 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 592316016150 acyl-activating enzyme (AAE) consensus motif; other site 592316016151 active site 592316016152 AMP binding site [chemical binding]; other site 592316016153 substrate binding site [chemical binding]; other site 592316016154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316016155 S-adenosylmethionine binding site [chemical binding]; other site 592316016156 Thioesterase domain; Region: Thioesterase; pfam00975 592316016157 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 592316016158 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 592316016159 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592316016160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316016161 NAD(P) binding site [chemical binding]; other site 592316016162 Condensation domain; Region: Condensation; pfam00668 592316016163 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 592316016164 Nonribosomal peptide synthase; Region: NRPS; pfam08415 592316016165 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 592316016166 acyl-activating enzyme (AAE) consensus motif; other site 592316016167 AMP binding site [chemical binding]; other site 592316016168 Methyltransferase domain; Region: Methyltransf_31; pfam13847 592316016169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316016170 S-adenosylmethionine binding site [chemical binding]; other site 592316016171 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 592316016172 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592316016173 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 592316016174 Phosphopantetheine attachment site; Region: PP-binding; cl09936 592316016175 Condensation domain; Region: Condensation; pfam00668 592316016176 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 592316016177 Nonribosomal peptide synthase; Region: NRPS; pfam08415 592316016178 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 592316016179 acyl-activating enzyme (AAE) consensus motif; other site 592316016180 AMP binding site [chemical binding]; other site 592316016181 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592316016182 Condensation domain; Region: Condensation; pfam00668 592316016183 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 592316016184 Nonribosomal peptide synthase; Region: NRPS; pfam08415 592316016185 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 592316016186 acyl-activating enzyme (AAE) consensus motif; other site 592316016187 AMP binding site [chemical binding]; other site 592316016188 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592316016189 Condensation domain; Region: Condensation; pfam00668 592316016190 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 592316016191 Nonribosomal peptide synthase; Region: NRPS; pfam08415 592316016192 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 592316016193 acyl-activating enzyme (AAE) consensus motif; other site 592316016194 AMP binding site [chemical binding]; other site 592316016195 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 592316016196 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 592316016197 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 592316016198 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592316016199 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316016200 metal binding site [ion binding]; metal-binding site 592316016201 active site 592316016202 I-site; other site 592316016203 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 592316016204 Transposase; Region: HTH_Tnp_1; pfam01527 592316016205 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 592316016206 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 592316016207 KTSC domain; Region: KTSC; pfam13619 592316016208 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 592316016209 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 592316016210 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 592316016211 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592316016212 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316016213 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 592316016214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316016215 dimer interface [polypeptide binding]; other site 592316016216 phosphorylation site [posttranslational modification] 592316016217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316016218 ATP binding site [chemical binding]; other site 592316016219 Mg2+ binding site [ion binding]; other site 592316016220 G-X-G motif; other site 592316016221 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592316016222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316016223 active site 592316016224 phosphorylation site [posttranslational modification] 592316016225 intermolecular recognition site; other site 592316016226 dimerization interface [polypeptide binding]; other site 592316016227 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592316016228 DNA binding site [nucleotide binding] 592316016229 MltA-interacting protein MipA; Region: MipA; cl01504 592316016230 hypothetical protein; Provisional; Region: PRK10220 592316016231 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 592316016232 PhnA protein; Region: PhnA; pfam03831 592316016233 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 592316016234 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 592316016235 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 592316016236 oxidoreductase; Provisional; Region: PRK07985 592316016237 NAD binding site [chemical binding]; other site 592316016238 metal binding site [ion binding]; metal-binding site 592316016239 active site 592316016240 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 592316016241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316016242 putative substrate translocation pore; other site 592316016243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316016244 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592316016245 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316016246 Predicted amidohydrolase [General function prediction only]; Region: COG0388 592316016247 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 592316016248 putative active site [active] 592316016249 catalytic triad [active] 592316016250 putative dimer interface [polypeptide binding]; other site 592316016251 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 592316016252 hypothetical protein; Provisional; Region: PRK10428 592316016253 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 592316016254 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 592316016255 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316016256 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316016257 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316016258 dimerization interface [polypeptide binding]; other site 592316016259 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 592316016260 acetolactate synthase; Reviewed; Region: PRK08617 592316016261 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 592316016262 PYR/PP interface [polypeptide binding]; other site 592316016263 dimer interface [polypeptide binding]; other site 592316016264 TPP binding site [chemical binding]; other site 592316016265 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 592316016266 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 592316016267 TPP-binding site [chemical binding]; other site 592316016268 dimer interface [polypeptide binding]; other site 592316016269 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 592316016270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316016271 putative PBP binding loops; other site 592316016272 ABC-ATPase subunit interface; other site 592316016273 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 592316016274 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 592316016275 Walker A/P-loop; other site 592316016276 ATP binding site [chemical binding]; other site 592316016277 Q-loop/lid; other site 592316016278 ABC transporter signature motif; other site 592316016279 Walker B; other site 592316016280 D-loop; other site 592316016281 H-loop/switch region; other site 592316016282 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 592316016283 NMT1-like family; Region: NMT1_2; pfam13379 592316016284 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 592316016285 catalytic residue [active] 592316016286 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 592316016287 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 592316016288 DNA-binding site [nucleotide binding]; DNA binding site 592316016289 RNA-binding motif; other site 592316016290 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 592316016291 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 592316016292 putative dimer interface [polypeptide binding]; other site 592316016293 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 592316016294 KTSC domain; Region: KTSC; pfam13619 592316016295 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 592316016296 enolase; Provisional; Region: eno; PRK00077 592316016297 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 592316016298 dimer interface [polypeptide binding]; other site 592316016299 metal binding site [ion binding]; metal-binding site 592316016300 substrate binding pocket [chemical binding]; other site 592316016301 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 592316016302 Ligand Binding Site [chemical binding]; other site 592316016303 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 592316016304 DHHA2 domain; Region: DHHA2; pfam02833 592316016305 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 592316016306 RadC-like JAB domain; Region: RadC; pfam04002 592316016307 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 592316016308 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 592316016309 Sensors of blue-light using FAD; Region: BLUF; smart01034 592316016310 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592316016311 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 592316016312 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 592316016313 Protein of unknown function (DUF551); Region: DUF551; pfam04448 592316016314 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939 592316016315 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 592316016316 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 592316016317 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 592316016318 active site 592316016319 Na/Ca binding site [ion binding]; other site 592316016320 catalytic site [active] 592316016321 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 592316016322 non-specific DNA binding site [nucleotide binding]; other site 592316016323 salt bridge; other site 592316016324 sequence-specific DNA binding site [nucleotide binding]; other site 592316016325 Glycogen synthesis protein; Region: GlgS; cl11663 592316016326 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 592316016327 amphipathic channel; other site 592316016328 Asn-Pro-Ala signature motifs; other site 592316016329 YqjK-like protein; Region: YqjK; pfam13997 592316016330 Predicted membrane protein [Function unknown]; Region: COG5393 592316016331 PAS fold; Region: PAS_4; pfam08448 592316016332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 592316016333 putative active site [active] 592316016334 heme pocket [chemical binding]; other site 592316016335 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592316016336 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316016337 metal binding site [ion binding]; metal-binding site 592316016338 active site 592316016339 I-site; other site 592316016340 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 592316016341 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 592316016342 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592316016343 Predicted transcriptional regulators [Transcription]; Region: COG1733 592316016344 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592316016345 dimerization interface [polypeptide binding]; other site 592316016346 putative DNA binding site [nucleotide binding]; other site 592316016347 putative Zn2+ binding site [ion binding]; other site 592316016348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 592316016349 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 592316016350 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 592316016351 GAF domain; Region: GAF; pfam01590 592316016352 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592316016353 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316016354 metal binding site [ion binding]; metal-binding site 592316016355 I-site; other site 592316016356 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592316016357 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 592316016358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316016359 NAD(P) binding site [chemical binding]; other site 592316016360 active site 592316016361 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 592316016362 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 592316016363 NAD(P) binding site [chemical binding]; other site 592316016364 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 592316016365 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 592316016366 NAD binding site [chemical binding]; other site 592316016367 dimerization interface [polypeptide binding]; other site 592316016368 product binding site; other site 592316016369 substrate binding site [chemical binding]; other site 592316016370 zinc binding site [ion binding]; other site 592316016371 catalytic residues [active] 592316016372 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 592316016373 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 592316016374 Walker A/P-loop; other site 592316016375 ATP binding site [chemical binding]; other site 592316016376 Q-loop/lid; other site 592316016377 ABC transporter signature motif; other site 592316016378 Walker B; other site 592316016379 D-loop; other site 592316016380 H-loop/switch region; other site 592316016381 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 592316016382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316016383 dimer interface [polypeptide binding]; other site 592316016384 conserved gate region; other site 592316016385 putative PBP binding loops; other site 592316016386 ABC-ATPase subunit interface; other site 592316016387 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 592316016388 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 592316016389 Transcriptional regulators [Transcription]; Region: FadR; COG2186 592316016390 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316016391 DNA-binding site [nucleotide binding]; DNA binding site 592316016392 FCD domain; Region: FCD; pfam07729 592316016393 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 592316016394 homotrimer interaction site [polypeptide binding]; other site 592316016395 putative active site [active] 592316016396 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316016397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316016398 dimer interface [polypeptide binding]; other site 592316016399 conserved gate region; other site 592316016400 putative PBP binding loops; other site 592316016401 ABC-ATPase subunit interface; other site 592316016402 Mediator complex subunit 24 N-terminal; Region: Med24_N; pfam11277 592316016403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316016404 dimer interface [polypeptide binding]; other site 592316016405 conserved gate region; other site 592316016406 putative PBP binding loops; other site 592316016407 ABC-ATPase subunit interface; other site 592316016408 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316016409 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316016410 Walker A/P-loop; other site 592316016411 ATP binding site [chemical binding]; other site 592316016412 Q-loop/lid; other site 592316016413 ABC transporter signature motif; other site 592316016414 Walker B; other site 592316016415 D-loop; other site 592316016416 H-loop/switch region; other site 592316016417 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316016418 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316016419 substrate binding pocket [chemical binding]; other site 592316016420 membrane-bound complex binding site; other site 592316016421 hinge residues; other site 592316016422 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 592316016423 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 592316016424 active site 592316016425 Zn binding site [ion binding]; other site 592316016426 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 592316016427 tetramer interface [polypeptide binding]; other site 592316016428 hypothetical protein; Provisional; Region: PRK06815 592316016429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316016430 catalytic residue [active] 592316016431 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316016432 non-specific DNA binding site [nucleotide binding]; other site 592316016433 salt bridge; other site 592316016434 sequence-specific DNA binding site [nucleotide binding]; other site 592316016435 HipA N-terminal domain; Region: Couple_hipA; cl11853 592316016436 HipA-like N-terminal domain; Region: HipA_N; pfam07805 592316016437 HipA-like C-terminal domain; Region: HipA_C; pfam07804 592316016438 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592316016439 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 592316016440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316016441 NAD(P) binding site [chemical binding]; other site 592316016442 active site 592316016443 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 592316016444 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 592316016445 Walker A/P-loop; other site 592316016446 ATP binding site [chemical binding]; other site 592316016447 Q-loop/lid; other site 592316016448 ABC transporter signature motif; other site 592316016449 Walker B; other site 592316016450 D-loop; other site 592316016451 H-loop/switch region; other site 592316016452 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 592316016453 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592316016454 ABC-ATPase subunit interface; other site 592316016455 dimer interface [polypeptide binding]; other site 592316016456 putative PBP binding regions; other site 592316016457 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 592316016458 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 592316016459 ABC-ATPase subunit interface; other site 592316016460 dimer interface [polypeptide binding]; other site 592316016461 putative PBP binding regions; other site 592316016462 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 592316016463 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 592316016464 siderophore binding site; other site 592316016465 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 592316016466 Secretin and TonB N terminus short domain; Region: STN; smart00965 592316016467 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316016468 N-terminal plug; other site 592316016469 ligand-binding site [chemical binding]; other site 592316016470 fec operon regulator FecR; Reviewed; Region: PRK09774 592316016471 FecR protein; Region: FecR; pfam04773 592316016472 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 592316016473 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592316016474 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592316016475 DNA binding residues [nucleotide binding] 592316016476 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592316016477 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316016478 DNA binding site [nucleotide binding] 592316016479 domain linker motif; other site 592316016480 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 592316016481 dimerization interface [polypeptide binding]; other site 592316016482 ligand binding site [chemical binding]; other site 592316016483 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316016484 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316016485 substrate binding pocket [chemical binding]; other site 592316016486 membrane-bound complex binding site; other site 592316016487 hinge residues; other site 592316016488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316016489 dimer interface [polypeptide binding]; other site 592316016490 conserved gate region; other site 592316016491 putative PBP binding loops; other site 592316016492 ABC-ATPase subunit interface; other site 592316016493 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316016494 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316016495 Walker A/P-loop; other site 592316016496 ATP binding site [chemical binding]; other site 592316016497 Q-loop/lid; other site 592316016498 ABC transporter signature motif; other site 592316016499 Walker B; other site 592316016500 D-loop; other site 592316016501 H-loop/switch region; other site 592316016502 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 592316016503 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 592316016504 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 592316016505 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 592316016506 TraX protein; Region: TraX; cl05434 592316016507 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 592316016508 active site 592316016509 metal binding site [ion binding]; metal-binding site 592316016510 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 592316016511 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 592316016512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316016513 dimer interface [polypeptide binding]; other site 592316016514 conserved gate region; other site 592316016515 putative PBP binding loops; other site 592316016516 ABC-ATPase subunit interface; other site 592316016517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316016518 dimer interface [polypeptide binding]; other site 592316016519 conserved gate region; other site 592316016520 putative PBP binding loops; other site 592316016521 ABC-ATPase subunit interface; other site 592316016522 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 592316016523 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 592316016524 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 592316016525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316016526 Walker A/P-loop; other site 592316016527 ATP binding site [chemical binding]; other site 592316016528 Q-loop/lid; other site 592316016529 ABC transporter signature motif; other site 592316016530 Walker B; other site 592316016531 D-loop; other site 592316016532 H-loop/switch region; other site 592316016533 TOBE domain; Region: TOBE_2; pfam08402 592316016534 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 592316016535 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 592316016536 G1 box; other site 592316016537 GTP/Mg2+ binding site [chemical binding]; other site 592316016538 Switch I region; other site 592316016539 G2 box; other site 592316016540 G3 box; other site 592316016541 Switch II region; other site 592316016542 G4 box; other site 592316016543 G5 box; other site 592316016544 Nucleoside recognition; Region: Gate; pfam07670 592316016545 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 592316016546 Nucleoside recognition; Region: Gate; pfam07670 592316016547 FeoA domain; Region: FeoA; cl00838 592316016548 ParA-like protein; Provisional; Region: PHA02518 592316016549 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 592316016550 P-loop; other site 592316016551 Magnesium ion binding site [ion binding]; other site 592316016552 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 592316016553 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 592316016554 molybdopterin cofactor binding site [chemical binding]; other site 592316016555 substrate binding site [chemical binding]; other site 592316016556 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 592316016557 molybdopterin cofactor binding site; other site 592316016558 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 592316016559 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 592316016560 Peptidase family M28; Region: Peptidase_M28; pfam04389 592316016561 metal binding site [ion binding]; metal-binding site 592316016562 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 592316016563 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316016564 substrate binding pocket [chemical binding]; other site 592316016565 membrane-bound complex binding site; other site 592316016566 hinge residues; other site 592316016567 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 592316016568 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 592316016569 metal binding site [ion binding]; metal-binding site 592316016570 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316016571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316016572 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592316016573 dimerization interface [polypeptide binding]; other site 592316016574 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 592316016575 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 592316016576 P-loop; other site 592316016577 Magnesium ion binding site [ion binding]; other site 592316016578 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 592316016579 Magnesium ion binding site [ion binding]; other site 592316016580 ParB-like nuclease domain; Region: ParB; smart00470 592316016581 ParB family; Region: ParB; pfam08775 592316016582 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 592316016583 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 592316016584 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 592316016585 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592316016586 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 592316016587 DNA binding residues [nucleotide binding] 592316016588 polysaccharide export protein Wza; Provisional; Region: PRK15078 592316016589 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 592316016590 SLBB domain; Region: SLBB; pfam10531 592316016591 Low molecular weight phosphatase family; Region: LMWPc; cd00115 592316016592 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 592316016593 active site 592316016594 tyrosine kinase; Provisional; Region: PRK11519 592316016595 Chain length determinant protein; Region: Wzz; pfam02706 592316016596 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 592316016597 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 592316016598 Nucleotide binding site [chemical binding]; other site 592316016599 DTAP/Switch II; other site 592316016600 Switch I; other site 592316016601 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592316016602 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 592316016603 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 592316016604 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 592316016605 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 592316016606 trimer interface [polypeptide binding]; other site 592316016607 active site 592316016608 substrate binding site [chemical binding]; other site 592316016609 CoA binding site [chemical binding]; other site 592316016610 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 592316016611 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592316016612 putative homodimer interface [polypeptide binding]; other site 592316016613 Right handed beta helix region; Region: Beta_helix; pfam13229 592316016614 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 592316016615 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 592316016616 Substrate binding site; other site 592316016617 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 592316016618 phosphomannomutase CpsG; Provisional; Region: PRK15414 592316016619 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 592316016620 active site 592316016621 substrate binding site [chemical binding]; other site 592316016622 metal binding site [ion binding]; metal-binding site 592316016623 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592316016624 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 592316016625 putative ADP-binding pocket [chemical binding]; other site 592316016626 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 592316016627 Bacterial sugar transferase; Region: Bac_transf; pfam02397 592316016628 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 592316016629 Acyltransferase family; Region: Acyl_transf_3; pfam01757 592316016630 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 592316016631 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 592316016632 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 592316016633 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 592316016634 active site 592316016635 substrate-binding site [chemical binding]; other site 592316016636 metal-binding site [ion binding] 592316016637 ATP binding site [chemical binding]; other site 592316016638 cell density-dependent motility repressor; Provisional; Region: PRK10082 592316016639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316016640 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592316016641 dimerization interface [polypeptide binding]; other site 592316016642 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 592316016643 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 592316016644 HAMP domain; Region: HAMP; pfam00672 592316016645 dimerization interface [polypeptide binding]; other site 592316016646 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 592316016647 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592316016648 dimer interface [polypeptide binding]; other site 592316016649 putative CheW interface [polypeptide binding]; other site 592316016650 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592316016651 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 592316016652 active site 592316016653 metal binding site [ion binding]; metal-binding site 592316016654 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 592316016655 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 592316016656 hydroperoxidase II; Provisional; Region: katE; PRK11249 592316016657 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 592316016658 tetramer interface [polypeptide binding]; other site 592316016659 heme binding pocket [chemical binding]; other site 592316016660 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 592316016661 domain interactions; other site 592316016662 Sigma-S stabilisation anti-adaptor protein; Region: Anti-adapt_IraP; cl11681 592316016663 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592316016664 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316016665 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 592316016666 homotrimer interaction site [polypeptide binding]; other site 592316016667 putative active site [active] 592316016668 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 592316016669 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 592316016670 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 592316016671 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316016672 Walker A/P-loop; other site 592316016673 ATP binding site [chemical binding]; other site 592316016674 Q-loop/lid; other site 592316016675 ABC transporter signature motif; other site 592316016676 Walker B; other site 592316016677 D-loop; other site 592316016678 H-loop/switch region; other site 592316016679 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316016680 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316016681 Walker A/P-loop; other site 592316016682 ATP binding site [chemical binding]; other site 592316016683 Q-loop/lid; other site 592316016684 ABC transporter signature motif; other site 592316016685 Walker B; other site 592316016686 D-loop; other site 592316016687 H-loop/switch region; other site 592316016688 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316016689 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 592316016690 active site residue [active] 592316016691 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 592316016692 active site residue [active] 592316016693 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 592316016694 D-cysteine desulfhydrase; Validated; Region: PRK03910 592316016695 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 592316016696 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592316016697 catalytic residue [active] 592316016698 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 592316016699 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 592316016700 metal binding site [ion binding]; metal-binding site 592316016701 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316016702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316016703 dimer interface [polypeptide binding]; other site 592316016704 conserved gate region; other site 592316016705 putative PBP binding loops; other site 592316016706 ABC-ATPase subunit interface; other site 592316016707 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 592316016708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316016709 dimer interface [polypeptide binding]; other site 592316016710 conserved gate region; other site 592316016711 putative PBP binding loops; other site 592316016712 ABC-ATPase subunit interface; other site 592316016713 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 592316016714 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 592316016715 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 592316016716 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316016717 DNA-binding site [nucleotide binding]; DNA binding site 592316016718 FCD domain; Region: FCD; pfam07729 592316016719 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 592316016720 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 592316016721 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 592316016722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 592316016723 N-acetyltransferase; Region: Acetyltransf_2; cl00949 592316016724 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 592316016725 Transposase; Region: DEDD_Tnp_IS110; pfam01548 592316016726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 592316016727 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 592316016728 Protein of unknown function, DUF481; Region: DUF481; cl01213 592316016729 Transposase; Region: HTH_Tnp_1; pfam01527 592316016730 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 592316016731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 592316016732 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 592316016733 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 592316016734 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 592316016735 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 592316016736 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 592316016737 Domain of unknown function (DUF932); Region: DUF932; pfam06067 592316016738 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 592316016739 N-acetyl-D-glucosamine binding site [chemical binding]; other site 592316016740 catalytic residue [active] 592316016741 TraM protein; Region: Tra_M; cl11621 592316016742 TraA; Region: TraA; cl11503 592316016743 TraL protein; Region: TraL; cl06278 592316016744 TraE protein; Region: TraE; cl05060 592316016745 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 592316016746 TraK protein; Region: TraK; pfam06586 592316016747 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 592316016748 DASH complex subunit Dad2; Region: DASH_Dad2; pfam08654 592316016749 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 592316016750 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 592316016751 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 592316016752 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 592316016753 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 592316016754 type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759 592316016755 conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721 592316016756 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 592316016757 Type-F conjugative transfer system protein (TrbI_Ftype); Region: TrbI_Ftype; pfam09677 592316016758 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 592316016759 TraU protein; Region: TraU; cl06067 592316016760 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 592316016761 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 592316016762 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 592316016763 F plasmid transfer operon protein; Region: TraF; pfam13728 592316016764 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 592316016765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316016766 AAA domain; Region: AAA_22; pfam13401 592316016767 Walker A motif; other site 592316016768 ATP binding site [chemical binding]; other site 592316016769 Walker B motif; other site 592316016770 conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723 592316016771 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 592316016772 Adenovirus GP19K; Region: Adeno_GP19K; pfam04881 592316016773 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 592316016774 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 592316016775 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 592316016776 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 592316016777 dimer interface [polypeptide binding]; other site 592316016778 PYR/PP interface [polypeptide binding]; other site 592316016779 TPP binding site [chemical binding]; other site 592316016780 substrate binding site [chemical binding]; other site 592316016781 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 592316016782 Domain of unknown function; Region: EKR; pfam10371 592316016783 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 592316016784 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 592316016785 TPP-binding site [chemical binding]; other site 592316016786 dimer interface [polypeptide binding]; other site 592316016787 Flagellin N-methylase; Region: FliB; pfam03692 592316016788 Transcriptional regulators [Transcription]; Region: GntR; COG1802 592316016789 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316016790 DNA-binding site [nucleotide binding]; DNA binding site 592316016791 FCD domain; Region: FCD; pfam07729 592316016792 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 592316016793 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 592316016794 ligand binding site [chemical binding]; other site 592316016795 NAD binding site [chemical binding]; other site 592316016796 catalytic site [active] 592316016797 hypothetical protein; Validated; Region: PRK06201 592316016798 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 592316016799 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 592316016800 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 592316016801 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 592316016802 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 592316016803 active site 592316016804 intersubunit interface [polypeptide binding]; other site 592316016805 catalytic residue [active] 592316016806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316016807 D-galactonate transporter; Region: 2A0114; TIGR00893 592316016808 putative substrate translocation pore; other site 592316016809 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 592316016810 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 592316016811 active site pocket [active] 592316016812 shikimate transporter; Provisional; Region: PRK09952 592316016813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316016814 putative substrate translocation pore; other site 592316016815 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 592316016816 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 592316016817 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592316016818 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 592316016819 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316016820 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316016821 Cytochrome c; Region: Cytochrom_C; pfam00034 592316016822 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 592316016823 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 592316016824 putative ligand binding residues [chemical binding]; other site 592316016825 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 592316016826 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316016827 N-terminal plug; other site 592316016828 ligand-binding site [chemical binding]; other site 592316016829 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592316016830 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316016831 SnoaL-like domain; Region: SnoaL_2; pfam12680 592316016832 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592316016833 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316016834 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 592316016835 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 592316016836 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592316016837 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316016838 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316016839 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 592316016840 Walker A/P-loop; other site 592316016841 ATP binding site [chemical binding]; other site 592316016842 Q-loop/lid; other site 592316016843 ABC transporter signature motif; other site 592316016844 Walker B; other site 592316016845 D-loop; other site 592316016846 H-loop/switch region; other site 592316016847 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 592316016848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316016849 Walker A/P-loop; other site 592316016850 ATP binding site [chemical binding]; other site 592316016851 Q-loop/lid; other site 592316016852 ABC transporter signature motif; other site 592316016853 Walker B; other site 592316016854 D-loop; other site 592316016855 H-loop/switch region; other site 592316016856 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 592316016857 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 592316016858 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 592316016859 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 592316016860 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 592316016861 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 592316016862 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 592316016863 active site clefts [active] 592316016864 zinc binding site [ion binding]; other site 592316016865 dimer interface [polypeptide binding]; other site 592316016866 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316016867 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316016868 Cytochrome c; Region: Cytochrom_C; pfam00034 592316016869 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 592316016870 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592316016871 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 592316016872 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 592316016873 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 592316016874 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316016875 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 592316016876 dimerization interface [polypeptide binding]; other site 592316016877 substrate binding pocket [chemical binding]; other site 592316016878 SnoaL-like domain; Region: SnoaL_2; pfam12680 592316016879 Uncharacterized conserved protein [Function unknown]; Region: COG1359 592316016880 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 592316016881 substrate binding site [chemical binding]; other site 592316016882 THF binding site; other site 592316016883 zinc-binding site [ion binding]; other site 592316016884 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 592316016885 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316016886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316016887 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316016888 dimerization interface [polypeptide binding]; other site 592316016889 YCII-related domain; Region: YCII; pfam03795 592316016890 AAA ATPase domain; Region: AAA_16; pfam13191 592316016891 AAA domain; Region: AAA_22; pfam13401 592316016892 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592316016893 dimerization interface [polypeptide binding]; other site 592316016894 putative DNA binding site [nucleotide binding]; other site 592316016895 putative Zn2+ binding site [ion binding]; other site 592316016896 ACT domain-containing protein [General function prediction only]; Region: COG4747 592316016897 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 592316016898 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 592316016899 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 592316016900 Trp docking motif [polypeptide binding]; other site 592316016901 putative active site [active] 592316016902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316016903 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 592316016904 Walker A motif; other site 592316016905 ATP binding site [chemical binding]; other site 592316016906 Walker B motif; other site 592316016907 arginine finger; other site 592316016908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316016909 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 592316016910 Walker A motif; other site 592316016911 ATP binding site [chemical binding]; other site 592316016912 Walker B motif; other site 592316016913 arginine finger; other site 592316016914 WYL domain; Region: WYL; pfam13280 592316016915 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 592316016916 putative active site [active] 592316016917 catalytic site [active] 592316016918 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 592316016919 putative Mg++ binding site [ion binding]; other site 592316016920 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 592316016921 nucleotide binding region [chemical binding]; other site 592316016922 ATP-binding site [chemical binding]; other site 592316016923 Nuclease-related domain; Region: NERD; pfam08378 592316016924 Family description; Region: UvrD_C_2; pfam13538 592316016925 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592316016926 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 592316016927 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316016928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316016929 dimer interface [polypeptide binding]; other site 592316016930 conserved gate region; other site 592316016931 putative PBP binding loops; other site 592316016932 ABC-ATPase subunit interface; other site 592316016933 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 592316016934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316016935 dimer interface [polypeptide binding]; other site 592316016936 conserved gate region; other site 592316016937 putative PBP binding loops; other site 592316016938 ABC-ATPase subunit interface; other site 592316016939 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 592316016940 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316016941 Walker A/P-loop; other site 592316016942 ATP binding site [chemical binding]; other site 592316016943 Q-loop/lid; other site 592316016944 ABC transporter signature motif; other site 592316016945 Walker B; other site 592316016946 D-loop; other site 592316016947 H-loop/switch region; other site 592316016948 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316016949 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316016950 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 592316016951 Walker A/P-loop; other site 592316016952 ATP binding site [chemical binding]; other site 592316016953 Q-loop/lid; other site 592316016954 ABC transporter signature motif; other site 592316016955 Walker B; other site 592316016956 D-loop; other site 592316016957 H-loop/switch region; other site 592316016958 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 592316016959 hypothetical protein; Provisional; Region: PRK07079 592316016960 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 592316016961 metal binding site [ion binding]; metal-binding site 592316016962 putative dimer interface [polypeptide binding]; other site 592316016963 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 592316016964 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316016965 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316016966 dimerization interface [polypeptide binding]; other site 592316016967 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 592316016968 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 592316016969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316016970 catalytic residue [active] 592316016971 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 592316016972 EamA-like transporter family; Region: EamA; pfam00892 592316016973 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 592316016974 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592316016975 putative DNA binding site [nucleotide binding]; other site 592316016976 putative Zn2+ binding site [ion binding]; other site 592316016977 AsnC family; Region: AsnC_trans_reg; pfam01037 592316016978 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592316016979 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316016980 non-specific DNA binding site [nucleotide binding]; other site 592316016981 salt bridge; other site 592316016982 sequence-specific DNA binding site [nucleotide binding]; other site 592316016983 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 592316016984 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 592316016985 NAD binding site [chemical binding]; other site 592316016986 EthD domain; Region: EthD; cl17553 592316016987 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 592316016988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316016989 putative substrate translocation pore; other site 592316016990 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592316016991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316016992 Isochorismatase family; Region: Isochorismatase; pfam00857 592316016993 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 592316016994 catalytic triad [active] 592316016995 conserved cis-peptide bond; other site 592316016996 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 592316016997 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592316016998 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316016999 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 592316017000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316017001 putative substrate translocation pore; other site 592316017002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316017003 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 592316017004 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592316017005 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316017006 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 592316017007 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 592316017008 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316017009 non-specific DNA binding site [nucleotide binding]; other site 592316017010 salt bridge; other site 592316017011 sequence-specific DNA binding site [nucleotide binding]; other site 592316017012 2TM domain; Region: 2TM; pfam13239 592316017013 Protein of unknown function DUF91; Region: DUF91; cl00709 592316017014 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 592316017015 active site 592316017016 DNA binding site [nucleotide binding] 592316017017 Int/Topo IB signature motif; other site 592316017018 Fic family protein [Function unknown]; Region: COG3177 592316017019 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 592316017020 Fic/DOC family; Region: Fic; pfam02661 592316017021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316017022 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 592316017023 putative substrate translocation pore; other site 592316017024 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 592316017025 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 592316017026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316017027 active site 592316017028 phosphorylation site [posttranslational modification] 592316017029 intermolecular recognition site; other site 592316017030 dimerization interface [polypeptide binding]; other site 592316017031 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592316017032 DNA binding site [nucleotide binding] 592316017033 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 592316017034 HAMP domain; Region: HAMP; pfam00672 592316017035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316017036 dimer interface [polypeptide binding]; other site 592316017037 phosphorylation site [posttranslational modification] 592316017038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316017039 ATP binding site [chemical binding]; other site 592316017040 Mg2+ binding site [ion binding]; other site 592316017041 G-X-G motif; other site 592316017042 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 592316017043 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 592316017044 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 592316017045 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 592316017046 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 592316017047 catalytic site [active] 592316017048 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592316017049 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592316017050 active site 592316017051 catalytic tetrad [active] 592316017052 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592316017053 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592316017054 active site 592316017055 catalytic tetrad [active] 592316017056 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592316017057 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316017058 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 592316017059 substrate binding site [chemical binding]; other site 592316017060 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 592316017061 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316017062 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316017063 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 592316017064 putative dimerization interface [polypeptide binding]; other site 592316017065 putative effector binding pocket; other site 592316017066 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 592316017067 Beta-lactamase; Region: Beta-lactamase; pfam00144 592316017068 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 592316017069 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 592316017070 putative NAD(P) binding site [chemical binding]; other site 592316017071 dimer interface [polypeptide binding]; other site 592316017072 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 592316017073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316017074 putative substrate translocation pore; other site 592316017075 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 592316017076 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 592316017077 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 592316017078 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 592316017079 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 592316017080 inhibitor-cofactor binding pocket; inhibition site 592316017081 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316017082 catalytic residue [active] 592316017083 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 592316017084 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 592316017085 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 592316017086 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 592316017087 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 592316017088 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 592316017089 putative active site [active] 592316017090 N-formylglutamate amidohydrolase; Region: FGase; cl01522 592316017091 Isochorismatase family; Region: Isochorismatase; pfam00857 592316017092 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 592316017093 catalytic triad [active] 592316017094 conserved cis-peptide bond; other site 592316017095 MltA-interacting protein MipA; Region: MipA; cl01504 592316017096 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592316017097 dimerization interface [polypeptide binding]; other site 592316017098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 592316017099 dimer interface [polypeptide binding]; other site 592316017100 phosphorylation site [posttranslational modification] 592316017101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316017102 ATP binding site [chemical binding]; other site 592316017103 Mg2+ binding site [ion binding]; other site 592316017104 G-X-G motif; other site 592316017105 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 592316017106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 592316017107 active site 592316017108 phosphorylation site [posttranslational modification] 592316017109 intermolecular recognition site; other site 592316017110 dimerization interface [polypeptide binding]; other site 592316017111 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 592316017112 DNA binding site [nucleotide binding] 592316017113 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 592316017114 putative deacylase active site [active] 592316017115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316017116 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 592316017117 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 592316017118 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316017119 DNA binding site [nucleotide binding] 592316017120 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 592316017121 putative ligand binding site [chemical binding]; other site 592316017122 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 592316017123 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592316017124 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592316017125 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592316017126 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592316017127 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592316017128 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592316017129 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 592316017130 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 592316017131 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 592316017132 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 592316017133 putative ligand binding site [chemical binding]; other site 592316017134 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592316017135 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592316017136 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592316017137 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 592316017138 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 592316017139 ligand binding site [chemical binding]; other site 592316017140 NAD binding site [chemical binding]; other site 592316017141 dimerization interface [polypeptide binding]; other site 592316017142 catalytic site [active] 592316017143 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 592316017144 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 592316017145 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 592316017146 tetramerization interface [polypeptide binding]; other site 592316017147 NAD(P) binding site [chemical binding]; other site 592316017148 catalytic residues [active] 592316017149 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 592316017150 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 592316017151 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 592316017152 putative active site [active] 592316017153 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 592316017154 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 592316017155 PYR/PP interface [polypeptide binding]; other site 592316017156 dimer interface [polypeptide binding]; other site 592316017157 TPP binding site [chemical binding]; other site 592316017158 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 592316017159 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 592316017160 TPP-binding site [chemical binding]; other site 592316017161 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 592316017162 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 592316017163 short chain dehydrogenase; Provisional; Region: PRK06198 592316017164 classical (c) SDRs; Region: SDR_c; cd05233 592316017165 NAD(P) binding site [chemical binding]; other site 592316017166 active site 592316017167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316017168 dimer interface [polypeptide binding]; other site 592316017169 conserved gate region; other site 592316017170 putative PBP binding loops; other site 592316017171 ABC-ATPase subunit interface; other site 592316017172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316017173 dimer interface [polypeptide binding]; other site 592316017174 conserved gate region; other site 592316017175 putative PBP binding loops; other site 592316017176 ABC-ATPase subunit interface; other site 592316017177 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316017178 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316017179 Walker A/P-loop; other site 592316017180 ATP binding site [chemical binding]; other site 592316017181 Q-loop/lid; other site 592316017182 ABC transporter signature motif; other site 592316017183 Walker B; other site 592316017184 D-loop; other site 592316017185 H-loop/switch region; other site 592316017186 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316017187 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316017188 substrate binding pocket [chemical binding]; other site 592316017189 membrane-bound complex binding site; other site 592316017190 hinge residues; other site 592316017191 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 592316017192 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 592316017193 active site 592316017194 non-prolyl cis peptide bond; other site 592316017195 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 592316017196 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316017197 Walker A/P-loop; other site 592316017198 ATP binding site [chemical binding]; other site 592316017199 Q-loop/lid; other site 592316017200 ABC transporter signature motif; other site 592316017201 Walker B; other site 592316017202 D-loop; other site 592316017203 H-loop/switch region; other site 592316017204 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316017205 Walker A/P-loop; other site 592316017206 ATP binding site [chemical binding]; other site 592316017207 Q-loop/lid; other site 592316017208 ABC transporter signature motif; other site 592316017209 Walker B; other site 592316017210 D-loop; other site 592316017211 H-loop/switch region; other site 592316017212 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316017213 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 592316017214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316017215 dimer interface [polypeptide binding]; other site 592316017216 conserved gate region; other site 592316017217 putative PBP binding loops; other site 592316017218 ABC-ATPase subunit interface; other site 592316017219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 592316017220 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316017221 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592316017222 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 592316017223 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592316017224 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 592316017225 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316017226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316017227 dimer interface [polypeptide binding]; other site 592316017228 conserved gate region; other site 592316017229 putative PBP binding loops; other site 592316017230 ABC-ATPase subunit interface; other site 592316017231 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 592316017232 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 592316017233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316017234 dimer interface [polypeptide binding]; other site 592316017235 conserved gate region; other site 592316017236 putative PBP binding loops; other site 592316017237 ABC-ATPase subunit interface; other site 592316017238 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316017239 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 592316017240 Walker A/P-loop; other site 592316017241 ATP binding site [chemical binding]; other site 592316017242 Q-loop/lid; other site 592316017243 ABC transporter signature motif; other site 592316017244 Walker B; other site 592316017245 D-loop; other site 592316017246 H-loop/switch region; other site 592316017247 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 592316017248 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 592316017249 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316017250 Walker A/P-loop; other site 592316017251 ATP binding site [chemical binding]; other site 592316017252 Q-loop/lid; other site 592316017253 ABC transporter signature motif; other site 592316017254 Walker B; other site 592316017255 D-loop; other site 592316017256 H-loop/switch region; other site 592316017257 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 592316017258 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 592316017259 tetramer interface [polypeptide binding]; other site 592316017260 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 592316017261 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 592316017262 tetramer interface [polypeptide binding]; other site 592316017263 active site 592316017264 metal binding site [ion binding]; metal-binding site 592316017265 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 592316017266 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 592316017267 active site 592316017268 non-prolyl cis peptide bond; other site 592316017269 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 592316017270 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316017271 Walker A/P-loop; other site 592316017272 ATP binding site [chemical binding]; other site 592316017273 Q-loop/lid; other site 592316017274 ABC transporter signature motif; other site 592316017275 Walker B; other site 592316017276 D-loop; other site 592316017277 H-loop/switch region; other site 592316017278 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 592316017279 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316017280 Walker A/P-loop; other site 592316017281 ATP binding site [chemical binding]; other site 592316017282 Q-loop/lid; other site 592316017283 ABC transporter signature motif; other site 592316017284 Walker B; other site 592316017285 D-loop; other site 592316017286 H-loop/switch region; other site 592316017287 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 592316017288 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 592316017289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316017290 dimer interface [polypeptide binding]; other site 592316017291 conserved gate region; other site 592316017292 putative PBP binding loops; other site 592316017293 ABC-ATPase subunit interface; other site 592316017294 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316017295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316017296 dimer interface [polypeptide binding]; other site 592316017297 conserved gate region; other site 592316017298 putative PBP binding loops; other site 592316017299 ABC-ATPase subunit interface; other site 592316017300 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592316017301 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 592316017302 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 592316017303 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 592316017304 Flavin binding site [chemical binding]; other site 592316017305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316017306 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592316017307 putative substrate translocation pore; other site 592316017308 Transcriptional regulator [Transcription]; Region: IclR; COG1414 592316017309 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 592316017310 Bacterial transcriptional regulator; Region: IclR; pfam01614 592316017311 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 592316017312 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 592316017313 hypothetical protein; Provisional; Region: PRK09945 592316017314 hypothetical protein; Provisional; Region: PRK09945 592316017315 hypothetical protein; Provisional; Region: PRK09945 592316017316 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 592316017317 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 592316017318 Autotransporter beta-domain; Region: Autotransporter; pfam03797 592316017319 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 592316017320 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 592316017321 active site 592316017322 non-prolyl cis peptide bond; other site 592316017323 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 592316017324 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 592316017325 metal binding site [ion binding]; metal-binding site 592316017326 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 592316017327 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 592316017328 active site 592316017329 non-prolyl cis peptide bond; other site 592316017330 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 592316017331 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316017332 Walker A/P-loop; other site 592316017333 ATP binding site [chemical binding]; other site 592316017334 Q-loop/lid; other site 592316017335 ABC transporter signature motif; other site 592316017336 Walker B; other site 592316017337 D-loop; other site 592316017338 H-loop/switch region; other site 592316017339 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316017340 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316017341 Walker A/P-loop; other site 592316017342 ATP binding site [chemical binding]; other site 592316017343 Q-loop/lid; other site 592316017344 ABC transporter signature motif; other site 592316017345 Walker B; other site 592316017346 D-loop; other site 592316017347 H-loop/switch region; other site 592316017348 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316017349 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 592316017350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316017351 dimer interface [polypeptide binding]; other site 592316017352 conserved gate region; other site 592316017353 putative PBP binding loops; other site 592316017354 ABC-ATPase subunit interface; other site 592316017355 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316017356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 592316017357 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 592316017358 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 592316017359 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316017360 Coenzyme A binding pocket [chemical binding]; other site 592316017361 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592316017362 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316017363 metal binding site [ion binding]; metal-binding site 592316017364 active site 592316017365 I-site; other site 592316017366 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 592316017367 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 592316017368 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 592316017369 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 592316017370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316017371 D-galactonate transporter; Region: 2A0114; TIGR00893 592316017372 putative substrate translocation pore; other site 592316017373 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 592316017374 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316017375 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 592316017376 dimerization interface [polypeptide binding]; other site 592316017377 substrate binding pocket [chemical binding]; other site 592316017378 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 592316017379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316017380 putative substrate translocation pore; other site 592316017381 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 592316017382 tartrate dehydrogenase; Region: TTC; TIGR02089 592316017383 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 592316017384 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 592316017385 MOFRL family; Region: MOFRL; pfam05161 592316017386 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 592316017387 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 592316017388 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 592316017389 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316017390 Cytochrome c; Region: Cytochrom_C; cl11414 592316017391 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316017392 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 592316017393 malonic semialdehyde reductase; Provisional; Region: PRK10538 592316017394 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 592316017395 putative NAD(P) binding site [chemical binding]; other site 592316017396 homotetramer interface [polypeptide binding]; other site 592316017397 homodimer interface [polypeptide binding]; other site 592316017398 active site 592316017399 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 592316017400 active site 1 [active] 592316017401 dimer interface [polypeptide binding]; other site 592316017402 hexamer interface [polypeptide binding]; other site 592316017403 active site 2 [active] 592316017404 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 592316017405 substrate binding site [chemical binding]; other site 592316017406 Uncharacterized conserved protein [Function unknown]; Region: COG1359 592316017407 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 592316017408 Predicted transcriptional regulators [Transcription]; Region: COG1695 592316017409 Transcriptional regulator PadR-like family; Region: PadR; cl17335 592316017410 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 592316017411 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 592316017412 active site 592316017413 catalytic tetrad [active] 592316017414 TLC ATP/ADP transporter; Region: TLC; cl03940 592316017415 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592316017416 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 592316017417 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 592316017418 Trp docking motif [polypeptide binding]; other site 592316017419 putative active site [active] 592316017420 Predicted peptidase [General function prediction only]; Region: COG4099 592316017421 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592316017422 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 592316017423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316017424 S-adenosylmethionine binding site [chemical binding]; other site 592316017425 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592316017426 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316017427 ParG; Region: ParG; pfam09274 592316017428 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 592316017429 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 592316017430 P-loop; other site 592316017431 Magnesium ion binding site [ion binding]; other site 592316017432 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 592316017433 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 592316017434 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 592316017435 MFS/sugar transport protein; Region: MFS_2; pfam13347 592316017436 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 592316017437 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 592316017438 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 592316017439 Initiator Replication protein; Region: Rep_3; cl17676 592316017440 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 592316017441 4Fe-4S binding domain; Region: Fer4; pfam00037 592316017442 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592316017443 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 592316017444 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316017445 Coenzyme A binding pocket [chemical binding]; other site 592316017446 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 592316017447 catalytic motif [active] 592316017448 Zn binding site [ion binding]; other site 592316017449 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 592316017450 putative active site pocket [active] 592316017451 dimerization interface [polypeptide binding]; other site 592316017452 putative catalytic residue [active] 592316017453 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 592316017454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316017455 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 592316017456 dimerization interface [polypeptide binding]; other site 592316017457 substrate binding pocket [chemical binding]; other site 592316017458 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592316017459 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 592316017460 dimer interface [polypeptide binding]; other site 592316017461 ligand binding site [chemical binding]; other site 592316017462 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 592316017463 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 592316017464 Methyltransferase domain; Region: Methyltransf_23; pfam13489 592316017465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316017466 S-adenosylmethionine binding site [chemical binding]; other site 592316017467 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316017468 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316017469 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 592316017470 putative effector binding pocket; other site 592316017471 dimerization interface [polypeptide binding]; other site 592316017472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316017473 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592316017474 putative substrate translocation pore; other site 592316017475 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 592316017476 catalytic residues [active] 592316017477 dimer interface [polypeptide binding]; other site 592316017478 Predicted transcriptional regulator [Transcription]; Region: COG1959 592316017479 Transcriptional regulator; Region: Rrf2; pfam02082 592316017480 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 592316017481 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 592316017482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 592316017483 S-adenosylmethionine binding site [chemical binding]; other site 592316017484 Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; pfam13957 592316017485 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 592316017486 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 592316017487 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 592316017488 classical (c) SDRs; Region: SDR_c; cd05233 592316017489 NAD(P) binding site [chemical binding]; other site 592316017490 active site 592316017491 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316017492 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316017493 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316017494 dimerization interface [polypeptide binding]; other site 592316017495 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 592316017496 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592316017497 dimerization interface [polypeptide binding]; other site 592316017498 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592316017499 dimer interface [polypeptide binding]; other site 592316017500 putative CheW interface [polypeptide binding]; other site 592316017501 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 592316017502 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 592316017503 conserved cys residue [active] 592316017504 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316017505 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316017506 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316017507 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 592316017508 putative effector binding pocket; other site 592316017509 putative dimerization interface [polypeptide binding]; other site 592316017510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316017511 putative substrate translocation pore; other site 592316017512 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592316017513 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 592316017514 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 592316017515 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 592316017516 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 592316017517 active site 592316017518 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 592316017519 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592316017520 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 592316017521 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 592316017522 FMN binding site [chemical binding]; other site 592316017523 active site 592316017524 substrate binding site [chemical binding]; other site 592316017525 catalytic residue [active] 592316017526 short chain dehydrogenase; Provisional; Region: PRK07577 592316017527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316017528 NAD(P) binding site [chemical binding]; other site 592316017529 active site 592316017530 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 592316017531 substrate binding site [chemical binding]; other site 592316017532 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 592316017533 trimer interface [polypeptide binding]; other site 592316017534 oxyanion hole (OAH) forming residues; other site 592316017535 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 592316017536 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 592316017537 C-terminal domain interface [polypeptide binding]; other site 592316017538 GSH binding site (G-site) [chemical binding]; other site 592316017539 dimer interface [polypeptide binding]; other site 592316017540 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 592316017541 N-terminal domain interface [polypeptide binding]; other site 592316017542 dimer interface [polypeptide binding]; other site 592316017543 substrate binding pocket (H-site) [chemical binding]; other site 592316017544 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316017545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316017546 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 592316017547 putative effector binding pocket; other site 592316017548 dimerization interface [polypeptide binding]; other site 592316017549 3-hydroxyanthranilic acid dioxygenase; Region: 3-HAO; cl17399 592316017550 Predicted flavoprotein [General function prediction only]; Region: COG0431 592316017551 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 592316017552 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 592316017553 Transcriptional regulators [Transcription]; Region: GntR; COG1802 592316017554 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316017555 DNA-binding site [nucleotide binding]; DNA binding site 592316017556 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 592316017557 drug efflux system protein MdtG; Provisional; Region: PRK09874 592316017558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316017559 putative substrate translocation pore; other site 592316017560 Isochorismatase family; Region: Isochorismatase; pfam00857 592316017561 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 592316017562 catalytic triad [active] 592316017563 conserved cis-peptide bond; other site 592316017564 hypothetical protein; Provisional; Region: PRK11469 592316017565 Domain of unknown function DUF; Region: DUF204; pfam02659 592316017566 Domain of unknown function DUF; Region: DUF204; pfam02659 592316017567 Transcriptional regulators [Transcription]; Region: FadR; COG2186 592316017568 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316017569 DNA-binding site [nucleotide binding]; DNA binding site 592316017570 FCD domain; Region: FCD; pfam07729 592316017571 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 592316017572 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316017573 substrate binding pocket [chemical binding]; other site 592316017574 membrane-bound complex binding site; other site 592316017575 hinge residues; other site 592316017576 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316017577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316017578 dimer interface [polypeptide binding]; other site 592316017579 conserved gate region; other site 592316017580 putative PBP binding loops; other site 592316017581 ABC-ATPase subunit interface; other site 592316017582 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316017583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316017584 dimer interface [polypeptide binding]; other site 592316017585 conserved gate region; other site 592316017586 putative PBP binding loops; other site 592316017587 ABC-ATPase subunit interface; other site 592316017588 Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Region: GlyA; COG0112 592316017589 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 592316017590 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592316017591 catalytic residue [active] 592316017592 SnoaL-like domain; Region: SnoaL_2; pfam12680 592316017593 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316017594 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316017595 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 592316017596 putative effector binding pocket; other site 592316017597 dimerization interface [polypeptide binding]; other site 592316017598 potential frameshift: common BLAST hit: gi|256419198|ref|YP_003119851.1| Glyoxalase/bleomycin resistance protein/dioxygenase 592316017599 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 592316017600 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 592316017601 active site 592316017602 metal binding site [ion binding]; metal-binding site 592316017603 short chain dehydrogenase; Provisional; Region: PRK06500 592316017604 classical (c) SDRs; Region: SDR_c; cd05233 592316017605 NAD(P) binding site [chemical binding]; other site 592316017606 active site 592316017607 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 592316017608 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 592316017609 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 592316017610 transport protein TonB; Provisional; Region: PRK10819 592316017611 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 592316017612 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 592316017613 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 592316017614 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 592316017615 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 592316017616 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 592316017617 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 592316017618 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 592316017619 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 592316017620 Helix-turn-helix domain; Region: HTH_18; pfam12833 592316017621 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316017622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316017623 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592316017624 putative substrate translocation pore; other site 592316017625 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 592316017626 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 592316017627 Putative Ig domain; Region: He_PIG; pfam05345 592316017628 Autotransporter beta-domain; Region: Autotransporter; smart00869 592316017629 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 592316017630 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 592316017631 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 592316017632 NifQ; Region: NifQ; pfam04891 592316017633 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 592316017634 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592316017635 FeS/SAM binding site; other site 592316017636 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 592316017637 Nif-specific regulatory protein; Region: nifA; TIGR01817 592316017638 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 592316017639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316017640 Walker A motif; other site 592316017641 ATP binding site [chemical binding]; other site 592316017642 Walker B motif; other site 592316017643 arginine finger; other site 592316017644 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 592316017645 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 592316017646 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 592316017647 putative active site [active] 592316017648 heme pocket [chemical binding]; other site 592316017649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 592316017650 ATP binding site [chemical binding]; other site 592316017651 G-X-G motif; other site 592316017652 flavodoxin FldA; Validated; Region: PRK09267 592316017653 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 592316017654 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 592316017655 NifZ domain; Region: NifZ; pfam04319 592316017656 Nitrogen fixation protein NifW; Region: NifW; cl03935 592316017657 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 592316017658 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 592316017659 active site 592316017660 catalytic residues [active] 592316017661 metal binding site [ion binding]; metal-binding site 592316017662 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 592316017663 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 592316017664 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592316017665 catalytic residue [active] 592316017666 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 592316017667 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 592316017668 trimerization site [polypeptide binding]; other site 592316017669 active site 592316017670 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 592316017671 NifU-like domain; Region: NifU; pfam01106 592316017672 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 592316017673 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 592316017674 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 592316017675 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 592316017676 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 592316017677 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 592316017678 NifT/FixU protein; Region: NifT; pfam06988 592316017679 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 592316017680 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 592316017681 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 592316017682 MoFe protein beta/alpha subunit interactions; other site 592316017683 Beta subunit P cluster binding residues; other site 592316017684 MoFe protein beta subunit/Fe protein contacts; other site 592316017685 MoFe protein dimer/ dimer interactions; other site 592316017686 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 592316017687 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 592316017688 MoFe protein alpha/beta subunit interactions; other site 592316017689 Alpha subunit P cluster binding residues; other site 592316017690 FeMoco binding residues [chemical binding]; other site 592316017691 MoFe protein alpha subunit/Fe protein contacts; other site 592316017692 MoFe protein dimer/ dimer interactions; other site 592316017693 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 592316017694 nitrogenase iron protein; Region: nifH; TIGR01287 592316017695 Nucleotide-binding sites [chemical binding]; other site 592316017696 Walker A motif; other site 592316017697 Switch I region of nucleotide binding site; other site 592316017698 Fe4S4 binding sites [ion binding]; other site 592316017699 Switch II region of nucleotide binding site; other site 592316017700 Protein of unknown function DUF2625; Region: DUF2625; cl08177 592316017701 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 592316017702 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592316017703 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316017704 DNA binding site [nucleotide binding] 592316017705 domain linker motif; other site 592316017706 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 592316017707 dimerization interface [polypeptide binding]; other site 592316017708 ligand binding site [chemical binding]; other site 592316017709 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316017710 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316017711 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 592316017712 putative substrate binding pocket [chemical binding]; other site 592316017713 putative dimerization interface [polypeptide binding]; other site 592316017714 Cupin domain; Region: Cupin_2; pfam07883 592316017715 glutathionine S-transferase; Provisional; Region: PRK10542 592316017716 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 592316017717 C-terminal domain interface [polypeptide binding]; other site 592316017718 GSH binding site (G-site) [chemical binding]; other site 592316017719 dimer interface [polypeptide binding]; other site 592316017720 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 592316017721 dimer interface [polypeptide binding]; other site 592316017722 N-terminal domain interface [polypeptide binding]; other site 592316017723 substrate binding pocket (H-site) [chemical binding]; other site 592316017724 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316017725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316017726 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592316017727 dimerization interface [polypeptide binding]; other site 592316017728 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 592316017729 outer membrane receptor FepA; Provisional; Region: PRK13524 592316017730 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316017731 N-terminal plug; other site 592316017732 ligand-binding site [chemical binding]; other site 592316017733 short chain dehydrogenase; Provisional; Region: PRK06500 592316017734 classical (c) SDRs; Region: SDR_c; cd05233 592316017735 NAD(P) binding site [chemical binding]; other site 592316017736 active site 592316017737 methionine synthase; Provisional; Region: PRK01207 592316017738 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 592316017739 substrate binding site [chemical binding]; other site 592316017740 THF binding site; other site 592316017741 zinc-binding site [ion binding]; other site 592316017742 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 592316017743 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592316017744 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 592316017745 putative substrate binding site [chemical binding]; other site 592316017746 putative ATP binding site [chemical binding]; other site 592316017747 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 592316017748 trimer interface; other site 592316017749 sugar binding site [chemical binding]; other site 592316017750 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 592316017751 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 592316017752 active site turn [active] 592316017753 phosphorylation site [posttranslational modification] 592316017754 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 592316017755 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 592316017756 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 592316017757 substrate binding [chemical binding]; other site 592316017758 active site 592316017759 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 592316017760 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 592316017761 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316017762 DNA binding site [nucleotide binding] 592316017763 domain linker motif; other site 592316017764 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 592316017765 dimerization interface [polypeptide binding]; other site 592316017766 ligand binding site [chemical binding]; other site 592316017767 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 592316017768 FMN binding site [chemical binding]; other site 592316017769 dimer interface [polypeptide binding]; other site 592316017770 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 592316017771 Probable cobalt transporter subunit (CbtA); Region: CbtA; pfam09490 592316017772 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 592316017773 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 592316017774 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 592316017775 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 592316017776 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 592316017777 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 592316017778 amidase; Provisional; Region: PRK07235 592316017779 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 592316017780 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 592316017781 Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816 592316017782 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 592316017783 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316017784 DinB family; Region: DinB; cl17821 592316017785 DinB superfamily; Region: DinB_2; pfam12867 592316017786 Divergent AAA domain; Region: AAA_4; pfam04326 592316017787 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 592316017788 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 592316017789 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 592316017790 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 592316017791 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 592316017792 DNA binding residues [nucleotide binding] 592316017793 EthD domain; Region: EthD; pfam07110 592316017794 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 592316017795 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 592316017796 putative ligand binding site [chemical binding]; other site 592316017797 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 592316017798 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 592316017799 Walker A/P-loop; other site 592316017800 ATP binding site [chemical binding]; other site 592316017801 Q-loop/lid; other site 592316017802 ABC transporter signature motif; other site 592316017803 Walker B; other site 592316017804 D-loop; other site 592316017805 H-loop/switch region; other site 592316017806 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 592316017807 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592316017808 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316017809 TM-ABC transporter signature motif; other site 592316017810 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316017811 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592316017812 TM-ABC transporter signature motif; other site 592316017813 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 592316017814 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 592316017815 active site 592316017816 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316017817 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316017818 substrate binding pocket [chemical binding]; other site 592316017819 membrane-bound complex binding site; other site 592316017820 hinge residues; other site 592316017821 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 592316017822 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316017823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316017824 dimer interface [polypeptide binding]; other site 592316017825 conserved gate region; other site 592316017826 ABC-ATPase subunit interface; other site 592316017827 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316017828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316017829 dimer interface [polypeptide binding]; other site 592316017830 conserved gate region; other site 592316017831 putative PBP binding loops; other site 592316017832 ABC-ATPase subunit interface; other site 592316017833 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316017834 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316017835 Walker A/P-loop; other site 592316017836 ATP binding site [chemical binding]; other site 592316017837 Q-loop/lid; other site 592316017838 ABC transporter signature motif; other site 592316017839 Walker B; other site 592316017840 D-loop; other site 592316017841 H-loop/switch region; other site 592316017842 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 592316017843 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 592316017844 homodimer interface [polypeptide binding]; other site 592316017845 substrate-cofactor binding pocket; other site 592316017846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316017847 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 592316017848 Coenzyme A binding pocket [chemical binding]; other site 592316017849 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 592316017850 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 592316017851 P-loop; other site 592316017852 Magnesium ion binding site [ion binding]; other site 592316017853 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 592316017854 Magnesium ion binding site [ion binding]; other site 592316017855 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 592316017856 ParB-like nuclease domain; Region: ParB; smart00470 592316017857 ParB family; Region: ParB; pfam08775 592316017858 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 592316017859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 592316017860 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 592316017861 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316017862 DNA-binding site [nucleotide binding]; DNA binding site 592316017863 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 592316017864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316017865 homodimer interface [polypeptide binding]; other site 592316017866 catalytic residue [active] 592316017867 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 592316017868 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 592316017869 Predicted amidohydrolase [General function prediction only]; Region: COG0388 592316017870 putative active site [active] 592316017871 catalytic triad [active] 592316017872 putative dimer interface [polypeptide binding]; other site 592316017873 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 592316017874 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 592316017875 FeS/SAM binding site; other site 592316017876 putative N-acetyltransferase, MSMEG_0567 N-terminal domain family; Region: MSMEG_0567_GNAT; TIGR04045 592316017877 Coenzyme A binding pocket [chemical binding]; other site 592316017878 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 592316017879 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 592316017880 dimerization interface [polypeptide binding]; other site 592316017881 putative ATP binding site [chemical binding]; other site 592316017882 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 592316017883 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 592316017884 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 592316017885 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 592316017886 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 592316017887 acyl-activating enzyme (AAE) consensus motif; other site 592316017888 AMP binding site [chemical binding]; other site 592316017889 active site 592316017890 CoA binding site [chemical binding]; other site 592316017891 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 592316017892 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 592316017893 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 592316017894 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 592316017895 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 592316017896 ligand binding site [chemical binding]; other site 592316017897 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 592316017898 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 592316017899 Walker A/P-loop; other site 592316017900 ATP binding site [chemical binding]; other site 592316017901 Q-loop/lid; other site 592316017902 ABC transporter signature motif; other site 592316017903 Walker B; other site 592316017904 D-loop; other site 592316017905 H-loop/switch region; other site 592316017906 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 592316017907 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316017908 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592316017909 TM-ABC transporter signature motif; other site 592316017910 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316017911 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592316017912 TM-ABC transporter signature motif; other site 592316017913 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 592316017914 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 592316017915 substrate binding site [chemical binding]; other site 592316017916 hexamer interface [polypeptide binding]; other site 592316017917 metal binding site [ion binding]; metal-binding site 592316017918 D-allose kinase; Provisional; Region: PRK09698 592316017919 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 592316017920 nucleotide binding site [chemical binding]; other site 592316017921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 592316017922 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592316017923 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 592316017924 substrate binding site [chemical binding]; other site 592316017925 dimer interface [polypeptide binding]; other site 592316017926 ATP binding site [chemical binding]; other site 592316017927 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 592316017928 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 592316017929 ligand binding site [chemical binding]; other site 592316017930 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 592316017931 active site 592316017932 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 592316017933 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316017934 substrate binding pocket [chemical binding]; other site 592316017935 membrane-bound complex binding site; other site 592316017936 hinge residues; other site 592316017937 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 592316017938 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 592316017939 potential catalytic triad [active] 592316017940 conserved cys residue [active] 592316017941 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 592316017942 NAD(P) binding site [chemical binding]; other site 592316017943 catalytic residues [active] 592316017944 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316017945 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316017946 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592316017947 dimerization interface [polypeptide binding]; other site 592316017948 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 592316017949 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 592316017950 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 592316017951 D-galactonate transporter; Region: 2A0114; TIGR00893 592316017952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316017953 putative substrate translocation pore; other site 592316017954 putative aldolase; Validated; Region: PRK08130 592316017955 intersubunit interface [polypeptide binding]; other site 592316017956 active site 592316017957 Zn2+ binding site [ion binding]; other site 592316017958 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 592316017959 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 592316017960 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 592316017961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 592316017962 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 592316017963 Tannase and feruloyl esterase; Region: Tannase; pfam07519 592316017964 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316017965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316017966 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 592316017967 putative effector binding pocket; other site 592316017968 dimerization interface [polypeptide binding]; other site 592316017969 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 592316017970 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 592316017971 FMN binding site [chemical binding]; other site 592316017972 active site 592316017973 substrate binding site [chemical binding]; other site 592316017974 catalytic residue [active] 592316017975 Uncharacterized conserved protein [Function unknown]; Region: COG3189 592316017976 outer membrane receptor FepA; Provisional; Region: PRK13528 592316017977 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316017978 N-terminal plug; other site 592316017979 ligand-binding site [chemical binding]; other site 592316017980 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 592316017981 outer membrane porin, OprD family; Region: OprD; pfam03573 592316017982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316017983 NAD(P) binding site [chemical binding]; other site 592316017984 active site 592316017985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316017986 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592316017987 putative substrate translocation pore; other site 592316017988 Cupin; Region: Cupin_6; pfam12852 592316017989 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 592316017990 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316017991 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 592316017992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316017993 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 592316017994 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 592316017995 putative ion selectivity filter; other site 592316017996 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 592316017997 putative pore gating glutamate residue; other site 592316017998 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 592316017999 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 592316018000 Protein export membrane protein; Region: SecD_SecF; cl14618 592316018001 Protein export membrane protein; Region: SecD_SecF; cl14618 592316018002 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 592316018003 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 592316018004 HlyD family secretion protein; Region: HlyD_3; pfam13437 592316018005 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 592316018006 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316018007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316018008 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 592316018009 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316018010 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316018011 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 592316018012 putative effector binding pocket; other site 592316018013 putative dimerization interface [polypeptide binding]; other site 592316018014 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 592316018015 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 592316018016 putative NAD(P) binding site [chemical binding]; other site 592316018017 putative substrate binding site [chemical binding]; other site 592316018018 catalytic Zn binding site [ion binding]; other site 592316018019 structural Zn binding site [ion binding]; other site 592316018020 dimer interface [polypeptide binding]; other site 592316018021 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 592316018022 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 592316018023 TLC ATP/ADP transporter; Region: TLC; cl03940 592316018024 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 592316018025 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 592316018026 short chain dehydrogenase; Provisional; Region: PRK06940 592316018027 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316018028 NAD(P) binding site [chemical binding]; other site 592316018029 active site 592316018030 transcriptional antiterminator BglG; Provisional; Region: PRK09772 592316018031 CAT RNA binding domain; Region: CAT_RBD; smart01061 592316018032 PRD domain; Region: PRD; pfam00874 592316018033 PRD domain; Region: PRD; pfam00874 592316018034 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 592316018035 beta-galactosidase; Region: BGL; TIGR03356 592316018036 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 592316018037 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 592316018038 active site turn [active] 592316018039 phosphorylation site [posttranslational modification] 592316018040 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 592316018041 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 592316018042 HPr interaction site; other site 592316018043 glycerol kinase (GK) interaction site [polypeptide binding]; other site 592316018044 active site 592316018045 phosphorylation site [posttranslational modification] 592316018046 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592316018047 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316018048 DNA binding site [nucleotide binding] 592316018049 domain linker motif; other site 592316018050 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 592316018051 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 592316018052 active site 592316018053 P-loop; other site 592316018054 phosphorylation site [posttranslational modification] 592316018055 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 592316018056 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 592316018057 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 592316018058 methionine cluster; other site 592316018059 active site 592316018060 phosphorylation site [posttranslational modification] 592316018061 metal binding site [ion binding]; metal-binding site 592316018062 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 592316018063 beta-galactosidase; Region: BGL; TIGR03356 592316018064 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 592316018065 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316018066 active site 592316018067 motif I; other site 592316018068 motif II; other site 592316018069 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 592316018070 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 592316018071 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 592316018072 NAD binding site [chemical binding]; other site 592316018073 sugar binding site [chemical binding]; other site 592316018074 divalent metal binding site [ion binding]; other site 592316018075 tetramer (dimer of dimers) interface [polypeptide binding]; other site 592316018076 dimer interface [polypeptide binding]; other site 592316018077 polyol permease family; Region: 2A0118; TIGR00897 592316018078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316018079 putative substrate translocation pore; other site 592316018080 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 592316018081 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 592316018082 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 592316018083 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 592316018084 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 592316018085 putative active site [active] 592316018086 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 592316018087 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 592316018088 substrate binding site [chemical binding]; other site 592316018089 dimer interface [polypeptide binding]; other site 592316018090 ATP binding site [chemical binding]; other site 592316018091 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 592316018092 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 592316018093 DNA-binding site [nucleotide binding]; DNA binding site 592316018094 FCD domain; Region: FCD; pfam07729 592316018095 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316018096 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316018097 substrate binding pocket [chemical binding]; other site 592316018098 membrane-bound complex binding site; other site 592316018099 hinge residues; other site 592316018100 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 592316018101 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592316018102 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 592316018103 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 592316018104 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 592316018105 hypothetical protein; Provisional; Region: PRK07206 592316018106 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 592316018107 hypothetical protein; Provisional; Region: PRK07206 592316018108 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 592316018109 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 592316018110 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 592316018111 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 592316018112 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 592316018113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316018114 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592316018115 putative substrate translocation pore; other site 592316018116 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 592316018117 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 592316018118 inhibitor site; inhibition site 592316018119 active site 592316018120 dimer interface [polypeptide binding]; other site 592316018121 catalytic residue [active] 592316018122 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 592316018123 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 592316018124 inhibitor site; inhibition site 592316018125 active site 592316018126 dimer interface [polypeptide binding]; other site 592316018127 catalytic residue [active] 592316018128 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 592316018129 Proline racemase; Region: Pro_racemase; pfam05544 592316018130 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 592316018131 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 592316018132 metal binding site [ion binding]; metal-binding site 592316018133 substrate binding pocket [chemical binding]; other site 592316018134 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 592316018135 FAD binding domain; Region: FAD_binding_4; pfam01565 592316018136 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 592316018137 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 592316018138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316018139 dimer interface [polypeptide binding]; other site 592316018140 conserved gate region; other site 592316018141 putative PBP binding loops; other site 592316018142 ABC-ATPase subunit interface; other site 592316018143 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316018144 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316018145 Walker A/P-loop; other site 592316018146 ATP binding site [chemical binding]; other site 592316018147 Q-loop/lid; other site 592316018148 ABC transporter signature motif; other site 592316018149 Walker B; other site 592316018150 D-loop; other site 592316018151 H-loop/switch region; other site 592316018152 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 592316018153 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 592316018154 NAD(P) binding site [chemical binding]; other site 592316018155 catalytic residues [active] 592316018156 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 592316018157 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 592316018158 dimer interface [polypeptide binding]; other site 592316018159 NADP binding site [chemical binding]; other site 592316018160 catalytic residues [active] 592316018161 Uncharacterized conserved protein [Function unknown]; Region: COG2128 592316018162 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 592316018163 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 592316018164 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 592316018165 Walker A/P-loop; other site 592316018166 ATP binding site [chemical binding]; other site 592316018167 Q-loop/lid; other site 592316018168 ABC transporter signature motif; other site 592316018169 Walker B; other site 592316018170 D-loop; other site 592316018171 H-loop/switch region; other site 592316018172 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 592316018173 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 592316018174 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316018175 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592316018176 TM-ABC transporter signature motif; other site 592316018177 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 592316018178 Strictosidine synthase; Region: Str_synth; pfam03088 592316018179 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 592316018180 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 592316018181 ligand binding site [chemical binding]; other site 592316018182 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 592316018183 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 592316018184 TM-ABC transporter signature motif; other site 592316018185 riboflavin synthase subunit beta; Provisional; Region: PRK12419 592316018186 active site 592316018187 homopentamer interface [polypeptide binding]; other site 592316018188 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 592316018189 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592316018190 DNA binding residues [nucleotide binding] 592316018191 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 592316018192 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 592316018193 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 592316018194 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 592316018195 substrate binding site [chemical binding]; other site 592316018196 dimer interface [polypeptide binding]; other site 592316018197 catalytic triad [active] 592316018198 dihydroxyacetone kinase; Provisional; Region: PRK14479 592316018199 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 592316018200 DAK2 domain; Region: Dak2; pfam02734 592316018201 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 592316018202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316018203 putative substrate translocation pore; other site 592316018204 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 592316018205 transketolase; Reviewed; Region: PRK12753 592316018206 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 592316018207 TPP-binding site [chemical binding]; other site 592316018208 dimer interface [polypeptide binding]; other site 592316018209 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 592316018210 PYR/PP interface [polypeptide binding]; other site 592316018211 dimer interface [polypeptide binding]; other site 592316018212 TPP binding site [chemical binding]; other site 592316018213 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 592316018214 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316018215 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316018216 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 592316018217 putative effector binding pocket; other site 592316018218 putative dimerization interface [polypeptide binding]; other site 592316018219 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 592316018220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 592316018221 putative substrate translocation pore; other site 592316018222 transaldolase-like protein; Provisional; Region: PTZ00411 592316018223 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 592316018224 active site 592316018225 dimer interface [polypeptide binding]; other site 592316018226 catalytic residue [active] 592316018227 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 592316018228 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 592316018229 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 592316018230 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 592316018231 active site 592316018232 P-loop; other site 592316018233 phosphorylation site [posttranslational modification] 592316018234 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 592316018235 regulatory protein interface [polypeptide binding]; other site 592316018236 active site 592316018237 regulatory phosphorylation site [posttranslational modification]; other site 592316018238 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 592316018239 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 592316018240 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 592316018241 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 592316018242 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 592316018243 active site 592316018244 phosphorylation site [posttranslational modification] 592316018245 putative phosphatase; Provisional; Region: PRK11587 592316018246 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 592316018247 motif II; other site 592316018248 putative hydrolase; Validated; Region: PRK09248 592316018249 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 592316018250 active site 592316018251 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 592316018252 active site 592316018253 P-loop; other site 592316018254 phosphorylation site [posttranslational modification] 592316018255 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 592316018256 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316018257 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 592316018258 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 592316018259 regulatory protein interface [polypeptide binding]; other site 592316018260 active site 592316018261 regulatory phosphorylation site [posttranslational modification]; other site 592316018262 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 592316018263 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 592316018264 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 592316018265 active site 592316018266 phosphorylation site [posttranslational modification] 592316018267 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316018268 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316018269 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 592316018270 putative effector binding pocket; other site 592316018271 putative dimerization interface [polypeptide binding]; other site 592316018272 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 592316018273 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 592316018274 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 592316018275 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 592316018276 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 592316018277 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 592316018278 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 592316018279 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316018280 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316018281 Cytochrome c; Region: Cytochrom_C; pfam00034 592316018282 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 592316018283 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 592316018284 XdhC Rossmann domain; Region: XdhC_C; pfam13478 592316018285 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 592316018286 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 592316018287 conserved cys residue [active] 592316018288 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 592316018289 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 592316018290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316018291 NAD(P) binding site [chemical binding]; other site 592316018292 active site 592316018293 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 592316018294 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 592316018295 LysE type translocator; Region: LysE; cl00565 592316018296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 592316018297 ACT domain; Region: ACT_3; pfam10000 592316018298 Family description; Region: ACT_7; pfam13840 592316018299 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 592316018300 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 592316018301 active site 592316018302 metal binding site [ion binding]; metal-binding site 592316018303 hexamer interface [polypeptide binding]; other site 592316018304 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 592316018305 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316018306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316018307 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 592316018308 dimerization interface [polypeptide binding]; other site 592316018309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316018310 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592316018311 putative substrate translocation pore; other site 592316018312 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 592316018313 putative heme binding pocket [chemical binding]; other site 592316018314 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 592316018315 RNA polymerase sigma factor; Provisional; Region: PRK12511 592316018316 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 592316018317 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 592316018318 DNA binding residues [nucleotide binding] 592316018319 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 592316018320 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 592316018321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 592316018322 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 592316018323 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 592316018324 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 592316018325 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 592316018326 dimerization interface [polypeptide binding]; other site 592316018327 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 592316018328 dimer interface [polypeptide binding]; other site 592316018329 putative CheW interface [polypeptide binding]; other site 592316018330 hypothetical protein; Provisional; Region: PRK06489 592316018331 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 592316018332 Predicted amidohydrolase [General function prediction only]; Region: COG0388 592316018333 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585 592316018334 putative active site [active] 592316018335 catalytic triad [active] 592316018336 putative dimer interface [polypeptide binding]; other site 592316018337 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 592316018338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316018339 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 592316018340 dimerization interface [polypeptide binding]; other site 592316018341 substrate binding pocket [chemical binding]; other site 592316018342 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 592316018343 heme-binding site [chemical binding]; other site 592316018344 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 592316018345 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 592316018346 metal binding site [ion binding]; metal-binding site 592316018347 active site 592316018348 I-site; other site 592316018349 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 592316018350 Predicted permeases [General function prediction only]; Region: COG0679 592316018351 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 592316018352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316018353 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 592316018354 dimerization interface [polypeptide binding]; other site 592316018355 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 592316018356 tetramer interface [polypeptide binding]; other site 592316018357 Predicted amidohydrolase [General function prediction only]; Region: COG0388 592316018358 active site 592316018359 catalytic triad [active] 592316018360 dimer interface [polypeptide binding]; other site 592316018361 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 592316018362 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 592316018363 homodimer interface [polypeptide binding]; other site 592316018364 substrate-cofactor binding pocket; other site 592316018365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 592316018366 catalytic residue [active] 592316018367 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 592316018368 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 592316018369 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316018370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316018371 dimer interface [polypeptide binding]; other site 592316018372 conserved gate region; other site 592316018373 putative PBP binding loops; other site 592316018374 ABC-ATPase subunit interface; other site 592316018375 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 592316018376 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 592316018377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316018378 dimer interface [polypeptide binding]; other site 592316018379 conserved gate region; other site 592316018380 putative PBP binding loops; other site 592316018381 ABC-ATPase subunit interface; other site 592316018382 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 592316018383 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316018384 Walker A/P-loop; other site 592316018385 ATP binding site [chemical binding]; other site 592316018386 Q-loop/lid; other site 592316018387 ABC transporter signature motif; other site 592316018388 Walker B; other site 592316018389 D-loop; other site 592316018390 H-loop/switch region; other site 592316018391 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316018392 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 592316018393 Walker A/P-loop; other site 592316018394 ATP binding site [chemical binding]; other site 592316018395 Q-loop/lid; other site 592316018396 ABC transporter signature motif; other site 592316018397 Walker B; other site 592316018398 D-loop; other site 592316018399 H-loop/switch region; other site 592316018400 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 592316018401 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 592316018402 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 592316018403 active site 592316018404 putative substrate binding pocket [chemical binding]; other site 592316018405 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 592316018406 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 592316018407 Helix-turn-helix domain; Region: HTH_39; pfam14090 592316018408 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592316018409 dimerization interface [polypeptide binding]; other site 592316018410 putative DNA binding site [nucleotide binding]; other site 592316018411 putative Zn2+ binding site [ion binding]; other site 592316018412 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 592316018413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 592316018414 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 592316018415 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 592316018416 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 592316018417 Transcriptional regulator [Transcription]; Region: IclR; COG1414 592316018418 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 592316018419 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316018420 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316018421 substrate binding pocket [chemical binding]; other site 592316018422 membrane-bound complex binding site; other site 592316018423 hinge residues; other site 592316018424 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 592316018425 active site 592316018426 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 592316018427 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 592316018428 metal binding site [ion binding]; metal-binding site 592316018429 dimer interface [polypeptide binding]; other site 592316018430 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 592316018431 PA/protease or protease-like domain interface [polypeptide binding]; other site 592316018432 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 592316018433 Peptidase family M28; Region: Peptidase_M28; pfam04389 592316018434 metal binding site [ion binding]; metal-binding site 592316018435 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 592316018436 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 592316018437 isoaspartyl dipeptidase; Provisional; Region: PRK10657 592316018438 active site 592316018439 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 592316018440 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 592316018441 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 592316018442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316018443 Walker A/P-loop; other site 592316018444 ATP binding site [chemical binding]; other site 592316018445 Q-loop/lid; other site 592316018446 ABC transporter signature motif; other site 592316018447 Walker B; other site 592316018448 D-loop; other site 592316018449 H-loop/switch region; other site 592316018450 TOBE domain; Region: TOBE_2; pfam08402 592316018451 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 592316018452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316018453 dimer interface [polypeptide binding]; other site 592316018454 conserved gate region; other site 592316018455 putative PBP binding loops; other site 592316018456 ABC-ATPase subunit interface; other site 592316018457 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 592316018458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316018459 dimer interface [polypeptide binding]; other site 592316018460 conserved gate region; other site 592316018461 putative PBP binding loops; other site 592316018462 ABC-ATPase subunit interface; other site 592316018463 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 592316018464 active site 592316018465 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 592316018466 catalytic site [active] 592316018467 Zn binding site [ion binding]; other site 592316018468 tetramer interface [polypeptide binding]; other site 592316018469 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316018470 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316018471 substrate binding pocket [chemical binding]; other site 592316018472 membrane-bound complex binding site; other site 592316018473 hinge residues; other site 592316018474 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 592316018475 active site 592316018476 catalytic site [active] 592316018477 Zn binding site [ion binding]; other site 592316018478 tetramer interface [polypeptide binding]; other site 592316018479 Winged helix-turn helix; Region: HTH_29; pfam13551 592316018480 Helix-turn-helix domain; Region: HTH_28; pfam13518 592316018481 Homeodomain-like domain; Region: HTH_32; pfam13565 592316018482 Integrase core domain; Region: rve; pfam00665 592316018483 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 592316018484 protein-splicing catalytic site; other site 592316018485 thioester formation/cholesterol transfer; other site 592316018486 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 592316018487 active site 592316018488 DNA binding site [nucleotide binding] 592316018489 Int/Topo IB signature motif; other site 592316018490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 592316018491 NADH(P)-binding; Region: NAD_binding_10; pfam13460 592316018492 NAD(P) binding site [chemical binding]; other site 592316018493 active site 592316018494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316018495 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592316018496 putative substrate translocation pore; other site 592316018497 Transcriptional regulator [Transcription]; Region: LysR; COG0583 592316018498 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 592316018499 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 592316018500 putative effector binding pocket; other site 592316018501 dimerization interface [polypeptide binding]; other site 592316018502 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 592316018503 trimer interface [polypeptide binding]; other site 592316018504 active site 592316018505 substrate binding site [chemical binding]; other site 592316018506 CoA binding site [chemical binding]; other site 592316018507 SnoaL-like domain; Region: SnoaL_4; pfam13577 592316018508 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 592316018509 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 592316018510 dimer interface [polypeptide binding]; other site 592316018511 active site 592316018512 metal binding site [ion binding]; metal-binding site 592316018513 short chain dehydrogenase; Provisional; Region: PRK06940 592316018514 classical (c) SDRs; Region: SDR_c; cd05233 592316018515 NAD(P) binding site [chemical binding]; other site 592316018516 active site 592316018517 multiple promoter invertase; Provisional; Region: mpi; PRK13413 592316018518 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 592316018519 catalytic residues [active] 592316018520 catalytic nucleophile [active] 592316018521 Presynaptic Site I dimer interface [polypeptide binding]; other site 592316018522 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 592316018523 Synaptic Flat tetramer interface [polypeptide binding]; other site 592316018524 Synaptic Site I dimer interface [polypeptide binding]; other site 592316018525 DNA binding site [nucleotide binding] 592316018526 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 592316018527 DNA-binding interface [nucleotide binding]; DNA binding site 592316018528 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 592316018529 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 592316018530 PAS fold; Region: PAS_4; pfam08448 592316018531 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 592316018532 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 592316018533 DNA binding residues [nucleotide binding] 592316018534 dimerization interface [polypeptide binding]; other site 592316018535 PAS fold; Region: PAS_4; pfam08448 592316018536 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 592316018537 DNA binding residues [nucleotide binding] 592316018538 dimerization interface [polypeptide binding]; other site 592316018539 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 592316018540 Predicted ATPase [General function prediction only]; Region: COG4637 592316018541 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 592316018542 Walker A/P-loop; other site 592316018543 ATP binding site [chemical binding]; other site 592316018544 hypothetical protein; Provisional; Region: PRK11019 592316018545 short chain dehydrogenase; Provisional; Region: PRK08219 592316018546 HetN oxidoreductase-like, classical (c) SDR; Region: HetN_like_SDR_c; cd08932 592316018547 putative NAD(P) binding site [chemical binding]; other site 592316018548 active site 592316018549 Abi-like protein; Region: Abi_2; pfam07751 592316018550 transcriptional regulator SgrR; Provisional; Region: PRK13626 592316018551 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 592316018552 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 592316018553 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 592316018554 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 592316018555 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 592316018556 shikimate binding site; other site 592316018557 NAD(P) binding site [chemical binding]; other site 592316018558 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 592316018559 methionine cluster; other site 592316018560 active site 592316018561 phosphorylation site [posttranslational modification] 592316018562 metal binding site [ion binding]; metal-binding site 592316018563 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 592316018564 beta-galactosidase; Region: BGL; TIGR03356 592316018565 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 592316018566 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 592316018567 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 592316018568 active site 592316018569 P-loop; other site 592316018570 phosphorylation site [posttranslational modification] 592316018571 catabolite control protein A; Region: ccpA; TIGR01481 592316018572 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316018573 DNA binding site [nucleotide binding] 592316018574 domain linker motif; other site 592316018575 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 592316018576 ligand binding site [chemical binding]; other site 592316018577 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 592316018578 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 592316018579 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 592316018580 active site 592316018581 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 592316018582 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 592316018583 active site turn [active] 592316018584 phosphorylation site [posttranslational modification] 592316018585 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 592316018586 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 592316018587 HPr interaction site; other site 592316018588 glycerol kinase (GK) interaction site [polypeptide binding]; other site 592316018589 active site 592316018590 phosphorylation site [posttranslational modification] 592316018591 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 592316018592 beta-galactosidase; Region: BGL; TIGR03356 592316018593 transcriptional antiterminator BglG; Provisional; Region: PRK09772 592316018594 CAT RNA binding domain; Region: CAT_RBD; smart01061 592316018595 PRD domain; Region: PRD; pfam00874 592316018596 PRD domain; Region: PRD; pfam00874 592316018597 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 592316018598 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 592316018599 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 592316018600 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 592316018601 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 592316018602 Cytochrome c; Region: Cytochrom_C; pfam00034 592316018603 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 592316018604 Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily; Region: eu-GS; cl00170 592316018605 putative aldolase; Validated; Region: PRK08130 592316018606 intersubunit interface [polypeptide binding]; other site 592316018607 active site 592316018608 Zn2+ binding site [ion binding]; other site 592316018609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316018610 D-galactonate transporter; Region: 2A0114; TIGR00893 592316018611 putative substrate translocation pore; other site 592316018612 Transcriptional regulators [Transcription]; Region: PurR; COG1609 592316018613 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 592316018614 DNA binding site [nucleotide binding] 592316018615 domain linker motif; other site 592316018616 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 592316018617 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 592316018618 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 592316018619 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 592316018620 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 592316018621 phosphate binding site [ion binding]; other site 592316018622 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 592316018623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 592316018624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 592316018625 Major Facilitator Superfamily; Region: MFS_1; pfam07690 592316018626 putative substrate translocation pore; other site 592316018627 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 592316018628 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 592316018629 catalytic residue [active] 592316018630 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 592316018631 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 592316018632 Walker A/P-loop; other site 592316018633 ATP binding site [chemical binding]; other site 592316018634 Q-loop/lid; other site 592316018635 ABC transporter signature motif; other site 592316018636 Walker B; other site 592316018637 D-loop; other site 592316018638 H-loop/switch region; other site 592316018639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316018640 dimer interface [polypeptide binding]; other site 592316018641 conserved gate region; other site 592316018642 putative PBP binding loops; other site 592316018643 ABC-ATPase subunit interface; other site 592316018644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 592316018645 dimer interface [polypeptide binding]; other site 592316018646 conserved gate region; other site 592316018647 putative PBP binding loops; other site 592316018648 ABC-ATPase subunit interface; other site 592316018649 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 592316018650 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 592316018651 substrate binding pocket [chemical binding]; other site 592316018652 membrane-bound complex binding site; other site 592316018653 hinge residues; other site 592316018654 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 592316018655 catalytic loop [active] 592316018656 iron binding site [ion binding]; other site 592316018657 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 592316018658 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 592316018659 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 592316018660 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 592316018661 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 592316018662 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 592316018663 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 592316018664 inhibitor site; inhibition site 592316018665 active site 592316018666 dimer interface [polypeptide binding]; other site 592316018667 catalytic residue [active] 592316018668 phenylhydantoinase; Validated; Region: PRK08323 592316018669 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 592316018670 tetramer interface [polypeptide binding]; other site 592316018671 active site 592316018672 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 592316018673 Transcriptional regulators [Transcription]; Region: GntR; COG1802 592316018674 FCD domain; Region: FCD; pfam07729 592316018675 Fic/DOC family; Region: Fic; pfam02661 592316018676 MarR family; Region: MarR_2; pfam12802 592316018677 Protein of unknown function (DUF1593); Region: DUF1593; pfam07632 592316018678 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 592316018679 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 592316018680 Lipopolysaccharide-assembly; Region: LptE; cl01125 592316018681 outer membrane receptor FepA; Provisional; Region: PRK13524 592316018682 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 592316018683 N-terminal plug; other site 592316018684 ligand-binding site [chemical binding]; other site 592316018685 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 592316018686 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 592316018687 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 592316018688 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 592316018689 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 592316018690 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 592316018691 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 592316018692 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 592316018693 Surface antigen; Region: Bac_surface_Ag; pfam01103 592316018694 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 592316018695 active site 592316018696 catalytic residues [active] 592316018697 DNA binding site [nucleotide binding] 592316018698 Int/Topo IB signature motif; other site 592316018699 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 592316018700 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 592316018701 P-loop; other site 592316018702 Magnesium ion binding site [ion binding]; other site 592316018703 HTH-like domain; Region: HTH_21; pfam13276 592316018704 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 592316018705 Integrase core domain; Region: rve; pfam00665 592316018706 Integrase core domain; Region: rve_3; pfam13683 592316018707 Transposase; Region: HTH_Tnp_1; pfam01527 592316018708 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 592316018709 RHS protein; Region: RHS; pfam03527 592316018710 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 592316018711 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 592316018712 hypothetical protein; Provisional; Region: PRK09956 592316018713 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 592316018714 multiple promoter invertase; Provisional; Region: mpi; PRK13413 592316018715 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 592316018716 catalytic residues [active] 592316018717 catalytic nucleophile [active] 592316018718 Presynaptic Site I dimer interface [polypeptide binding]; other site 592316018719 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 592316018720 Synaptic Flat tetramer interface [polypeptide binding]; other site 592316018721 Synaptic Site I dimer interface [polypeptide binding]; other site 592316018722 DNA binding site [nucleotide binding] 592316018723 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 592316018724 DNA-binding interface [nucleotide binding]; DNA binding site 592316018725 hypothetical protein; Provisional; Region: PRK10428 592316018726 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 592316018727 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 592316018728 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 592316018729 Transposase; Region: HTH_Tnp_1; cl17663 592316018730 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 592316018731 putative transposase OrfB; Reviewed; Region: PHA02517 592316018732 HTH-like domain; Region: HTH_21; pfam13276 592316018733 Integrase core domain; Region: rve; pfam00665 592316018734 Integrase core domain; Region: rve_2; pfam13333 592316018735 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 592316018736 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 592316018737 active site 592316018738 FRG domain; Region: FRG; cl07460 592316018739 Archaeal ATPase; Region: Arch_ATPase; pfam01637 592316018740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 592316018741 Walker A motif; other site 592316018742 ATP binding site [chemical binding]; other site 592316018743 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592316018744 dimerization interface [polypeptide binding]; other site 592316018745 putative DNA binding site [nucleotide binding]; other site 592316018746 Transcriptional regulators [Transcription]; Region: MarR; COG1846 592316018747 putative Zn2+ binding site [ion binding]; other site 592316018748 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 592316018749 active site residue [active] 592316018750 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 592316018751 Phage integrase family; Region: Phage_integrase; pfam00589 592316018752 active site 592316018753 DNA binding site [nucleotide binding] 592316018754 Int/Topo IB signature motif; other site 592316018755 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 592316018756 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 592316018757 P-loop; other site 592316018758 Magnesium ion binding site [ion binding]; other site 592316018759 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 592316018760 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 592316018761 active site 592316018762 DNA binding site [nucleotide binding] 592316018763 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 592316018764 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 592316018765 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 592316018766 Catalytic site [active] 592316018767 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 592316018768 DNA methylase; Region: N6_N4_Mtase; cl17433 592316018769 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 592316018770 Antirestriction protein; Region: Antirestrict; pfam03230 592316018771 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 592316018772 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 592316018773 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 592316018774 N-acetyl-D-glucosamine binding site [chemical binding]; other site 592316018775 catalytic residue [active] 592316018776 TraM protein; Region: Tra_M; cl11621 592316018777 Coronavirus S2 glycoprotein; Region: Corona_S2; pfam01601 592316018778 TraA; Region: TraA; cl11503 592316018779 TraL protein; Region: TraL; cl06278 592316018780 TraE protein; Region: TraE; cl05060 592316018781 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 592316018782 TraK protein; Region: TraK; pfam06586 592316018783 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 592316018784 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 592316018785 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 592316018786 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 592316018787 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 592316018788 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 592316018789 conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721 592316018790 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 592316018791 Type-F conjugative transfer system protein (TrbI_Ftype); Region: TrbI_Ftype; pfam09677 592316018792 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 592316018793 conjugal transfer pilus assembly protein TraU; Provisional; Region: PRK13737 592316018794 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 592316018795 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 592316018796 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 592316018797 F plasmid transfer operon protein; Region: TraF; pfam13728 592316018798 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 592316018799 conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723 592316018800 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 592316018801 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 592316018802 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 592316018803 type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759 592316018804 F sex factor protein N terminal; Region: TraD_N; pfam12615 592316018805 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 592316018806 Walker A motif; other site 592316018807 ATP binding site [chemical binding]; other site 592316018808 Walker B motif; other site 592316018809 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 592316018810 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 592316018811 AAA domain; Region: AAA_30; pfam13604 592316018812 DNA helicase TraI; Region: TraI; pfam07057 592316018813 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 592316018814 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 592316018815 Haemolysin expression modulating protein; Region: HHA; cl11501 592316018816 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 592316018817 PLD-like domain; Region: PLDc_2; pfam13091 592316018818 putative active site [active] 592316018819 catalytic site [active] 592316018820 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 592316018821 Predicted transcriptional regulators [Transcription]; Region: COG1733 592316018822 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 592316018823 dimerization interface [polypeptide binding]; other site 592316018824 putative DNA binding site [nucleotide binding]; other site 592316018825 putative Zn2+ binding site [ion binding]; other site 592316018826 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 592316018827 Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Region: ArgF; COG0078 592316018828 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 592316018829 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 592316018830 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 592316018831 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 592316018832 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 592316018833 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 592316018834 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 592316018835 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 592316018836 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 592316018837 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 592316018838 Transposase; Region: HTH_Tnp_1; pfam01527 592316018839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 592316018840 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 592316018841 Bacterial PH domain; Region: DUF304; cl01348 592316018842 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 592316018843 non-specific DNA binding site [nucleotide binding]; other site 592316018844 salt bridge; other site 592316018845 sequence-specific DNA binding site [nucleotide binding]; other site 592316018846 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 592316018847 putative transposase OrfB; Reviewed; Region: PHA02517 592316018848 HTH-like domain; Region: HTH_21; pfam13276 592316018849 Integrase core domain; Region: rve; pfam00665 592316018850 Integrase core domain; Region: rve_2; pfam13333 592316018851 Tannase and feruloyl esterase; Region: Tannase; pfam07519 592316018852 Protein of unknown function, DUF481; Region: DUF481; cl01213 592316018853 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 592316018854 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 592316018855 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 592316018856 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 592316018857 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 592316018858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 592316018859 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 592316018860 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 592316018861 Transposase; Region: HTH_Tnp_1; pfam01527