-- dump date 20140619_230618 -- class Genbank::misc_feature -- table misc_feature_note -- id note 932677000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 932677000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 932677000003 putative catalytic residues [active] 932677000004 putative nucleotide binding site [chemical binding]; other site 932677000005 putative aspartate binding site [chemical binding]; other site 932677000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 932677000007 dimer interface [polypeptide binding]; other site 932677000008 putative threonine allosteric regulatory site; other site 932677000009 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 932677000010 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 932677000011 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 932677000012 homoserine kinase; Provisional; Region: PRK01212 932677000013 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 932677000014 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 932677000015 threonine synthase; Validated; Region: PRK09225 932677000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 932677000017 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932677000018 catalytic residue [active] 932677000019 hypothetical protein; Validated; Region: PRK02101 932677000020 transaldolase-like protein; Provisional; Region: PTZ00411 932677000021 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 932677000022 active site 932677000023 dimer interface [polypeptide binding]; other site 932677000024 catalytic residue [active] 932677000025 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 932677000026 MPT binding site; other site 932677000027 trimer interface [polypeptide binding]; other site 932677000028 metabolite-proton symporter; Region: 2A0106; TIGR00883 932677000029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677000030 putative substrate translocation pore; other site 932677000031 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 932677000032 NAD-specific glutamate dehydrogenase; Region: NAD-GH; pfam10712 932677000033 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 932677000034 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 932677000035 nucleotide binding site [chemical binding]; other site 932677000036 chaperone protein DnaJ; Provisional; Region: PRK10767 932677000037 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 932677000038 HSP70 interaction site [polypeptide binding]; other site 932677000039 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 932677000040 substrate binding site [polypeptide binding]; other site 932677000041 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 932677000042 Zn binding sites [ion binding]; other site 932677000043 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 932677000044 dimer interface [polypeptide binding]; other site 932677000045 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 932677000046 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 932677000047 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 932677000048 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 932677000049 active site 932677000050 Riboflavin kinase; Region: Flavokinase; smart00904 932677000051 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 932677000052 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 932677000053 active site 932677000054 HIGH motif; other site 932677000055 nucleotide binding site [chemical binding]; other site 932677000056 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 932677000057 active site 932677000058 KMSKS motif; other site 932677000059 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 932677000060 tRNA binding surface [nucleotide binding]; other site 932677000061 anticodon binding site; other site 932677000062 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 932677000063 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 932677000064 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 932677000065 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 932677000066 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 932677000067 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 932677000068 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 932677000069 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 932677000070 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 932677000071 carbamoyl-phosphate synthase, small subunit; Region: CPSaseIIsmall; TIGR01368 932677000072 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 932677000073 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 932677000074 catalytic site [active] 932677000075 subunit interface [polypeptide binding]; other site 932677000076 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 932677000077 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 932677000078 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 932677000079 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 932677000080 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 932677000081 ATP-grasp domain; Region: ATP-grasp_4; cl17255 932677000082 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 932677000083 IMP binding site; other site 932677000084 dimer interface [polypeptide binding]; other site 932677000085 interdomain contacts; other site 932677000086 partial ornithine binding site; other site 932677000087 Mig-14; Region: Mig-14; pfam07395 932677000088 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 932677000089 NAD(P) binding site [chemical binding]; other site 932677000090 active site 932677000091 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677000092 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677000093 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 932677000094 dimerization interface [polypeptide binding]; other site 932677000095 putative effector binding pocket; other site 932677000096 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 932677000097 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 932677000098 eyelet of channel; other site 932677000099 trimer interface [polypeptide binding]; other site 932677000100 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 932677000101 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 932677000102 folate binding site [chemical binding]; other site 932677000103 NADP+ binding site [chemical binding]; other site 932677000104 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 932677000105 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 932677000106 active site 932677000107 metal binding site [ion binding]; metal-binding site 932677000108 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 932677000109 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 932677000110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677000111 S-adenosylmethionine binding site [chemical binding]; other site 932677000112 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 932677000113 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 932677000114 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 932677000115 SurA N-terminal domain; Region: SurA_N; pfam09312 932677000116 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 932677000117 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 932677000118 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 932677000119 OstA-like protein; Region: OstA; pfam03968 932677000120 Organic solvent tolerance protein; Region: OstA_C; pfam04453 932677000121 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 932677000122 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 932677000123 putative metal binding site [ion binding]; other site 932677000124 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 932677000125 HSP70 interaction site [polypeptide binding]; other site 932677000126 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 932677000127 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 932677000128 active site 932677000129 ATP-dependent helicase HepA; Validated; Region: PRK04914 932677000130 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932677000131 ATP binding site [chemical binding]; other site 932677000132 putative Mg++ binding site [ion binding]; other site 932677000133 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932677000134 nucleotide binding region [chemical binding]; other site 932677000135 ATP-binding site [chemical binding]; other site 932677000136 potential protein location (hypothetical protein) that overlaps protein (RNA polymerase associated protein RapA) 932677000137 DNA polymerase II; Reviewed; Region: PRK05762 932677000138 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 932677000139 active site 932677000140 catalytic site [active] 932677000141 substrate binding site [chemical binding]; other site 932677000142 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 932677000143 active site 932677000144 metal-binding site 932677000145 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 932677000146 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 932677000147 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 932677000148 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 932677000149 Walker A/P-loop; other site 932677000150 ATP binding site [chemical binding]; other site 932677000151 Q-loop/lid; other site 932677000152 ABC transporter signature motif; other site 932677000153 Walker B; other site 932677000154 D-loop; other site 932677000155 H-loop/switch region; other site 932677000156 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 932677000157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677000158 dimer interface [polypeptide binding]; other site 932677000159 conserved gate region; other site 932677000160 putative PBP binding loops; other site 932677000161 ABC-ATPase subunit interface; other site 932677000162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677000163 dimer interface [polypeptide binding]; other site 932677000164 conserved gate region; other site 932677000165 putative PBP binding loops; other site 932677000166 ABC-ATPase subunit interface; other site 932677000167 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 932677000168 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 932677000169 transcriptional regulator SgrR; Provisional; Region: PRK13626 932677000170 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 932677000171 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 932677000172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677000173 sugar efflux transporter; Region: 2A0120; TIGR00899 932677000174 putative substrate translocation pore; other site 932677000175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677000176 D-galactonate transporter; Region: 2A0114; TIGR00893 932677000177 putative substrate translocation pore; other site 932677000178 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677000179 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677000180 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 932677000181 putative dimerization interface [polypeptide binding]; other site 932677000182 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 932677000183 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 932677000184 active site 932677000185 catalytic residue [active] 932677000186 dimer interface [polypeptide binding]; other site 932677000187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677000188 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932677000189 putative substrate translocation pore; other site 932677000190 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 932677000191 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 932677000192 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 932677000193 shikimate binding site; other site 932677000194 NAD(P) binding site [chemical binding]; other site 932677000195 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 932677000196 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 932677000197 active site 932677000198 FMN binding site [chemical binding]; other site 932677000199 substrate binding site [chemical binding]; other site 932677000200 putative catalytic residue [active] 932677000201 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 932677000202 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932677000203 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 932677000204 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 932677000205 substrate binding site [chemical binding]; other site 932677000206 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 932677000207 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 932677000208 substrate binding site [chemical binding]; other site 932677000209 ligand binding site [chemical binding]; other site 932677000210 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 932677000211 tartrate dehydrogenase; Provisional; Region: PRK08194 932677000212 2-isopropylmalate synthase; Validated; Region: PRK00915 932677000213 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 932677000214 active site 932677000215 catalytic residues [active] 932677000216 metal binding site [ion binding]; metal-binding site 932677000217 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 932677000218 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 932677000219 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 932677000220 PYR/PP interface [polypeptide binding]; other site 932677000221 dimer interface [polypeptide binding]; other site 932677000222 TPP binding site [chemical binding]; other site 932677000223 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 932677000224 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 932677000225 TPP-binding site [chemical binding]; other site 932677000226 dimer interface [polypeptide binding]; other site 932677000227 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 932677000228 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 932677000229 putative valine binding site [chemical binding]; other site 932677000230 dimer interface [polypeptide binding]; other site 932677000231 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 932677000232 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 932677000233 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 932677000234 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 932677000235 dimerization interface [polypeptide binding]; other site 932677000236 ligand binding site [chemical binding]; other site 932677000237 cell division protein MraZ; Reviewed; Region: PRK00326 932677000238 MraZ protein; Region: MraZ; pfam02381 932677000239 MraZ protein; Region: MraZ; pfam02381 932677000240 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 932677000241 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 932677000242 cell division protein FtsL; Provisional; Region: PRK10772 932677000243 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 932677000244 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 932677000245 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 932677000246 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 932677000247 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 932677000248 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 932677000249 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 932677000250 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 932677000251 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 932677000252 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 932677000253 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 932677000254 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 932677000255 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 932677000256 Mg++ binding site [ion binding]; other site 932677000257 putative catalytic motif [active] 932677000258 putative substrate binding site [chemical binding]; other site 932677000259 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 932677000260 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 932677000261 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 932677000262 cell division protein FtsW; Provisional; Region: PRK10774 932677000263 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 932677000264 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 932677000265 active site 932677000266 homodimer interface [polypeptide binding]; other site 932677000267 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 932677000268 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 932677000269 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 932677000270 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 932677000271 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 932677000272 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 932677000273 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 932677000274 cell division protein FtsQ; Provisional; Region: PRK10775 932677000275 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 932677000276 Cell division protein FtsQ; Region: FtsQ; pfam03799 932677000277 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 932677000278 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932677000279 Cell division protein FtsA; Region: FtsA; pfam14450 932677000280 cell division protein FtsZ; Validated; Region: PRK09330 932677000281 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 932677000282 nucleotide binding site [chemical binding]; other site 932677000283 SulA interaction site; other site 932677000284 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 932677000285 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 932677000286 SecA regulator SecM; Provisional; Region: PRK02943 932677000287 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 932677000288 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 932677000289 SEC-C motif; Region: SEC-C; pfam02810 932677000290 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 932677000291 active site 932677000292 8-oxo-dGMP binding site [chemical binding]; other site 932677000293 nudix motif; other site 932677000294 metal binding site [ion binding]; metal-binding site 932677000295 Domain of unknown function (DUF329); Region: DUF329; cl01144 932677000296 hypothetical protein; Provisional; Region: PRK05287 932677000297 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 932677000298 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 932677000299 CoA-binding site [chemical binding]; other site 932677000300 ATP-binding [chemical binding]; other site 932677000301 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 932677000302 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 932677000303 active site 932677000304 type IV pilin biogenesis protein; Provisional; Region: PRK10573 932677000305 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 932677000306 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 932677000307 hypothetical protein; Provisional; Region: PRK10436 932677000308 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 932677000309 Walker A motif; other site 932677000310 ATP binding site [chemical binding]; other site 932677000311 Walker B motif; other site 932677000312 putative major pilin subunit; Provisional; Region: PRK10574 932677000313 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 932677000314 Pilin (bacterial filament); Region: Pilin; pfam00114 932677000315 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 932677000316 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 932677000317 dimerization interface [polypeptide binding]; other site 932677000318 active site 932677000319 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 932677000320 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 932677000321 amidase catalytic site [active] 932677000322 substrate binding site [chemical binding]; other site 932677000323 Zn binding residues [ion binding]; other site 932677000324 regulatory protein AmpE; Provisional; Region: PRK10987 932677000325 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 932677000326 active site 932677000327 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 932677000328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677000329 putative substrate translocation pore; other site 932677000330 aromatic amino acid transporter; Provisional; Region: PRK10238 932677000331 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 932677000332 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932677000333 DNA-binding site [nucleotide binding]; DNA binding site 932677000334 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 932677000335 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 932677000336 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 932677000337 dimer interface [polypeptide binding]; other site 932677000338 TPP-binding site [chemical binding]; other site 932677000339 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 932677000340 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 932677000341 E3 interaction surface; other site 932677000342 lipoyl attachment site [posttranslational modification]; other site 932677000343 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 932677000344 E3 interaction surface; other site 932677000345 lipoyl attachment site [posttranslational modification]; other site 932677000346 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 932677000347 E3 interaction surface; other site 932677000348 lipoyl attachment site [posttranslational modification]; other site 932677000349 e3 binding domain; Region: E3_binding; pfam02817 932677000350 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 932677000351 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 932677000352 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932677000353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932677000354 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 932677000355 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677000356 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677000357 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 932677000358 putative effector binding pocket; other site 932677000359 putative dimerization interface [polypeptide binding]; other site 932677000360 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932677000361 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932677000362 active site 932677000363 catalytic tetrad [active] 932677000364 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 932677000365 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 932677000366 substrate binding site [chemical binding]; other site 932677000367 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 932677000368 substrate binding site [chemical binding]; other site 932677000369 ligand binding site [chemical binding]; other site 932677000370 hypothetical protein; Provisional; Region: PRK05248 932677000371 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 932677000372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 932677000373 CHASE3 domain; Region: CHASE3; pfam05227 932677000374 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 932677000375 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932677000376 dimerization interface [polypeptide binding]; other site 932677000377 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677000378 dimer interface [polypeptide binding]; other site 932677000379 putative CheW interface [polypeptide binding]; other site 932677000380 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 932677000381 active site 932677000382 TDP-binding site; other site 932677000383 acceptor substrate-binding pocket; other site 932677000384 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 932677000385 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 932677000386 spermidine synthase; Provisional; Region: PRK00811 932677000387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677000388 S-adenosylmethionine binding site [chemical binding]; other site 932677000389 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 932677000390 multicopper oxidase; Provisional; Region: PRK10965 932677000391 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 932677000392 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 932677000393 methionine gamma-lyase; Validated; Region: PRK07049 932677000394 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 932677000395 homodimer interface [polypeptide binding]; other site 932677000396 substrate-cofactor binding pocket; other site 932677000397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677000398 catalytic residue [active] 932677000399 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932677000400 active site 932677000401 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 932677000402 active site clefts [active] 932677000403 zinc binding site [ion binding]; other site 932677000404 dimer interface [polypeptide binding]; other site 932677000405 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 932677000406 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 932677000407 Walker A/P-loop; other site 932677000408 ATP binding site [chemical binding]; other site 932677000409 Q-loop/lid; other site 932677000410 ABC transporter signature motif; other site 932677000411 Walker B; other site 932677000412 D-loop; other site 932677000413 H-loop/switch region; other site 932677000414 inner membrane transport permease; Provisional; Region: PRK15066 932677000415 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 932677000416 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 932677000417 tetramerization interface [polypeptide binding]; other site 932677000418 active site 932677000419 Pantoate-beta-alanine ligase; Region: PanC; cd00560 932677000420 pantoate--beta-alanine ligase; Region: panC; TIGR00018 932677000421 active site 932677000422 ATP-binding site [chemical binding]; other site 932677000423 pantoate-binding site; other site 932677000424 HXXH motif; other site 932677000425 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 932677000426 oligomerization interface [polypeptide binding]; other site 932677000427 active site 932677000428 metal binding site [ion binding]; metal-binding site 932677000429 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 932677000430 catalytic center binding site [active] 932677000431 ATP binding site [chemical binding]; other site 932677000432 poly(A) polymerase; Region: pcnB; TIGR01942 932677000433 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 932677000434 active site 932677000435 NTP binding site [chemical binding]; other site 932677000436 metal binding triad [ion binding]; metal-binding site 932677000437 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 932677000438 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 932677000439 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 932677000440 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 932677000441 active site 932677000442 nucleotide binding site [chemical binding]; other site 932677000443 HIGH motif; other site 932677000444 KMSKS motif; other site 932677000445 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 932677000446 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 932677000447 2'-5' RNA ligase; Provisional; Region: PRK15124 932677000448 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 932677000449 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 932677000450 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932677000451 ATP binding site [chemical binding]; other site 932677000452 putative Mg++ binding site [ion binding]; other site 932677000453 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932677000454 nucleotide binding region [chemical binding]; other site 932677000455 ATP-binding site [chemical binding]; other site 932677000456 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 932677000457 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 932677000458 Transglycosylase; Region: Transgly; pfam00912 932677000459 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 932677000460 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 932677000461 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 932677000462 N-terminal plug; other site 932677000463 ligand-binding site [chemical binding]; other site 932677000464 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 932677000465 Q-loop/lid; other site 932677000466 ABC transporter signature motif; other site 932677000467 Walker B; other site 932677000468 D-loop; other site 932677000469 H-loop/switch region; other site 932677000470 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 932677000471 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 932677000472 siderophore binding site; other site 932677000473 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 932677000474 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932677000475 ABC-ATPase subunit interface; other site 932677000476 dimer interface [polypeptide binding]; other site 932677000477 putative PBP binding regions; other site 932677000478 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932677000479 ABC-ATPase subunit interface; other site 932677000480 dimer interface [polypeptide binding]; other site 932677000481 putative PBP binding regions; other site 932677000482 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 932677000483 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 932677000484 inhibitor-cofactor binding pocket; inhibition site 932677000485 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677000486 catalytic residue [active] 932677000487 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 932677000488 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 932677000489 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 932677000490 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 932677000491 serine endoprotease; Provisional; Region: PRK10942 932677000492 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 932677000493 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 932677000494 protein binding site [polypeptide binding]; other site 932677000495 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 932677000496 protein binding site [polypeptide binding]; other site 932677000497 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 932677000498 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 932677000499 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 932677000500 Alginate lyase; Region: Alginate_lyase; pfam05426 932677000501 hypothetical protein; Provisional; Region: PRK13677 932677000502 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 932677000503 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 932677000504 trimer interface [polypeptide binding]; other site 932677000505 active site 932677000506 substrate binding site [chemical binding]; other site 932677000507 CoA binding site [chemical binding]; other site 932677000508 PII uridylyl-transferase; Provisional; Region: PRK05007 932677000509 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 932677000510 metal binding triad; other site 932677000511 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 932677000512 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932677000513 Zn2+ binding site [ion binding]; other site 932677000514 Mg2+ binding site [ion binding]; other site 932677000515 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 932677000516 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 932677000517 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 932677000518 active site 932677000519 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 932677000520 rRNA interaction site [nucleotide binding]; other site 932677000521 S8 interaction site; other site 932677000522 putative laminin-1 binding site; other site 932677000523 elongation factor Ts; Provisional; Region: tsf; PRK09377 932677000524 UBA/TS-N domain; Region: UBA; pfam00627 932677000525 Elongation factor TS; Region: EF_TS; pfam00889 932677000526 Elongation factor TS; Region: EF_TS; pfam00889 932677000527 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 932677000528 putative nucleotide binding site [chemical binding]; other site 932677000529 uridine monophosphate binding site [chemical binding]; other site 932677000530 homohexameric interface [polypeptide binding]; other site 932677000531 ribosome recycling factor; Reviewed; Region: frr; PRK00083 932677000532 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 932677000533 hinge region; other site 932677000534 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 932677000535 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 932677000536 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 932677000537 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 932677000538 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 932677000539 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 932677000540 catalytic residue [active] 932677000541 putative FPP diphosphate binding site; other site 932677000542 putative FPP binding hydrophobic cleft; other site 932677000543 dimer interface [polypeptide binding]; other site 932677000544 putative IPP diphosphate binding site; other site 932677000545 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 932677000546 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 932677000547 zinc metallopeptidase RseP; Provisional; Region: PRK10779 932677000548 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 932677000549 active site 932677000550 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 932677000551 protein binding site [polypeptide binding]; other site 932677000552 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 932677000553 protein binding site [polypeptide binding]; other site 932677000554 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 932677000555 putative substrate binding region [chemical binding]; other site 932677000556 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 932677000557 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 932677000558 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 932677000559 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 932677000560 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 932677000561 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 932677000562 Surface antigen; Region: Bac_surface_Ag; pfam01103 932677000563 periplasmic chaperone; Provisional; Region: PRK10780 932677000564 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 932677000565 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 932677000566 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 932677000567 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 932677000568 trimer interface [polypeptide binding]; other site 932677000569 active site 932677000570 UDP-GlcNAc binding site [chemical binding]; other site 932677000571 lipid binding site [chemical binding]; lipid-binding site 932677000572 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 932677000573 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 932677000574 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 932677000575 active site 932677000576 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 932677000577 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 932677000578 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 932677000579 RNA/DNA hybrid binding site [nucleotide binding]; other site 932677000580 active site 932677000581 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 932677000582 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 932677000583 putative active site [active] 932677000584 putative PHP Thumb interface [polypeptide binding]; other site 932677000585 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 932677000586 generic binding surface II; other site 932677000587 generic binding surface I; other site 932677000588 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 932677000589 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 932677000590 lysine decarboxylase LdcC; Provisional; Region: PRK15399 932677000591 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 932677000592 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 932677000593 homodimer interface [polypeptide binding]; other site 932677000594 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677000595 catalytic residue [active] 932677000596 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 932677000597 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 932677000598 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932677000599 putative metal binding site [ion binding]; other site 932677000600 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 932677000601 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 932677000602 Ligand Binding Site [chemical binding]; other site 932677000603 TilS substrate binding domain; Region: TilS; pfam09179 932677000604 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 932677000605 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 932677000606 hypothetical protein; Provisional; Region: PRK04964 932677000607 hypothetical protein; Provisional; Region: PRK09256 932677000608 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 932677000609 prolyl-tRNA synthetase; Provisional; Region: PRK09194 932677000610 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 932677000611 dimer interface [polypeptide binding]; other site 932677000612 motif 1; other site 932677000613 active site 932677000614 motif 2; other site 932677000615 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 932677000616 putative deacylase active site [active] 932677000617 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 932677000618 active site 932677000619 motif 3; other site 932677000620 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 932677000621 anticodon binding site; other site 932677000622 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 932677000623 homodimer interaction site [polypeptide binding]; other site 932677000624 cofactor binding site; other site 932677000625 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 932677000626 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 932677000627 lipoprotein, YaeC family; Region: TIGR00363 932677000628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677000629 dimer interface [polypeptide binding]; other site 932677000630 conserved gate region; other site 932677000631 ABC-ATPase subunit interface; other site 932677000632 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 932677000633 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 932677000634 Walker A/P-loop; other site 932677000635 ATP binding site [chemical binding]; other site 932677000636 Q-loop/lid; other site 932677000637 ABC transporter signature motif; other site 932677000638 Walker B; other site 932677000639 D-loop; other site 932677000640 H-loop/switch region; other site 932677000641 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 932677000642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677000643 motif II; other site 932677000644 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677000645 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 932677000646 dimerization interface [polypeptide binding]; other site 932677000647 hypothetical protein; Provisional; Region: PRK05421 932677000648 putative catalytic site [active] 932677000649 putative metal binding site [ion binding]; other site 932677000650 putative phosphate binding site [ion binding]; other site 932677000651 putative catalytic site [active] 932677000652 putative phosphate binding site [ion binding]; other site 932677000653 putative metal binding site [ion binding]; other site 932677000654 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 932677000655 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 932677000656 N-acetyl-D-glucosamine binding site [chemical binding]; other site 932677000657 catalytic residue [active] 932677000658 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932677000659 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932677000660 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 932677000661 Methyltransferase domain; Region: Methyltransf_11; pfam08241 932677000662 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 932677000663 RNA/DNA hybrid binding site [nucleotide binding]; other site 932677000664 active site 932677000665 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 932677000666 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 932677000667 active site 932677000668 catalytic site [active] 932677000669 substrate binding site [chemical binding]; other site 932677000670 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 932677000671 active site 932677000672 intersubunit interactions; other site 932677000673 catalytic residue [active] 932677000674 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 932677000675 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 932677000676 Na binding site [ion binding]; other site 932677000677 putative substrate binding site [chemical binding]; other site 932677000678 Transcriptional regulators [Transcription]; Region: GntR; COG1802 932677000679 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932677000680 DNA-binding site [nucleotide binding]; DNA binding site 932677000681 FCD domain; Region: FCD; pfam07729 932677000682 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 932677000683 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 932677000684 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 932677000685 active site 932677000686 catalytic site [active] 932677000687 tetramer interface [polypeptide binding]; other site 932677000688 hypothetical protein; Provisional; Region: PRK07490 932677000689 intersubunit interface [polypeptide binding]; other site 932677000690 active site 932677000691 Zn2+ binding site [ion binding]; other site 932677000692 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677000693 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 932677000694 substrate binding pocket [chemical binding]; other site 932677000695 membrane-bound complex binding site; other site 932677000696 hinge residues; other site 932677000697 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 932677000698 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 932677000699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677000700 dimer interface [polypeptide binding]; other site 932677000701 conserved gate region; other site 932677000702 putative PBP binding loops; other site 932677000703 ABC-ATPase subunit interface; other site 932677000704 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 932677000705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677000706 Walker A/P-loop; other site 932677000707 ATP binding site [chemical binding]; other site 932677000708 Q-loop/lid; other site 932677000709 ABC transporter signature motif; other site 932677000710 Walker B; other site 932677000711 D-loop; other site 932677000712 H-loop/switch region; other site 932677000713 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677000714 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677000715 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 932677000716 putative substrate binding pocket [chemical binding]; other site 932677000717 dimerization interface [polypeptide binding]; other site 932677000718 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932677000719 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 932677000720 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 932677000721 acetylornithine deacetylase; Provisional; Region: PRK07522 932677000722 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 932677000723 metal binding site [ion binding]; metal-binding site 932677000724 putative dimer interface [polypeptide binding]; other site 932677000725 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 932677000726 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 932677000727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677000728 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 932677000729 dimerization interface [polypeptide binding]; other site 932677000730 substrate binding pocket [chemical binding]; other site 932677000731 amidase; Provisional; Region: PRK09201 932677000732 Amidase; Region: Amidase; pfam01425 932677000733 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 932677000734 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 932677000735 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 932677000736 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932677000737 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932677000738 putative active site [active] 932677000739 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 932677000740 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677000741 substrate binding pocket [chemical binding]; other site 932677000742 membrane-bound complex binding site; other site 932677000743 hinge residues; other site 932677000744 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 932677000745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677000746 dimer interface [polypeptide binding]; other site 932677000747 conserved gate region; other site 932677000748 putative PBP binding loops; other site 932677000749 ABC-ATPase subunit interface; other site 932677000750 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 932677000751 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 932677000752 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 932677000753 Walker A/P-loop; other site 932677000754 ATP binding site [chemical binding]; other site 932677000755 Q-loop/lid; other site 932677000756 ABC transporter signature motif; other site 932677000757 Walker B; other site 932677000758 D-loop; other site 932677000759 H-loop/switch region; other site 932677000760 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 932677000761 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 932677000762 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932677000763 catalytic residue [active] 932677000764 allantoate amidohydrolase; Reviewed; Region: PRK09290 932677000765 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 932677000766 active site 932677000767 metal binding site [ion binding]; metal-binding site 932677000768 dimer interface [polypeptide binding]; other site 932677000769 OHCU decarboxylase; Region: UraD_2; TIGR03180 932677000770 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 932677000771 active site 932677000772 homotetramer interface [polypeptide binding]; other site 932677000773 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 932677000774 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 932677000775 heme binding site [chemical binding]; other site 932677000776 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 932677000777 heme binding site [chemical binding]; other site 932677000778 C-N hydrolase family amidase; Provisional; Region: PRK10438 932677000779 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 932677000780 putative active site [active] 932677000781 catalytic triad [active] 932677000782 dimer interface [polypeptide binding]; other site 932677000783 multimer interface [polypeptide binding]; other site 932677000784 methionine aminotransferase; Validated; Region: PRK09082 932677000785 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932677000786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677000787 homodimer interface [polypeptide binding]; other site 932677000788 catalytic residue [active] 932677000789 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 932677000790 intersubunit interface [polypeptide binding]; other site 932677000791 active site 932677000792 Zn2+ binding site [ion binding]; other site 932677000793 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 932677000794 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 932677000795 Cupin domain; Region: Cupin_2; cl17218 932677000796 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 932677000797 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 932677000798 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 932677000799 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 932677000800 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 932677000801 active site 932677000802 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 932677000803 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 932677000804 dimer interface [polypeptide binding]; other site 932677000805 active site 932677000806 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 932677000807 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 932677000808 putative active site [active] 932677000809 putative dimer interface [polypeptide binding]; other site 932677000810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 932677000811 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 932677000812 active site 932677000813 DNA polymerase IV; Validated; Region: PRK02406 932677000814 DNA binding site [nucleotide binding] 932677000815 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 932677000816 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 932677000817 putative ligand binding site [chemical binding]; other site 932677000818 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932677000819 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 932677000820 TM-ABC transporter signature motif; other site 932677000821 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 932677000822 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 932677000823 Walker A/P-loop; other site 932677000824 ATP binding site [chemical binding]; other site 932677000825 Q-loop/lid; other site 932677000826 ABC transporter signature motif; other site 932677000827 Walker B; other site 932677000828 D-loop; other site 932677000829 H-loop/switch region; other site 932677000830 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 932677000831 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 932677000832 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 932677000833 tetramer interface [polypeptide binding]; other site 932677000834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677000835 catalytic residue [active] 932677000836 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 932677000837 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 932677000838 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 932677000839 metal binding site [ion binding]; metal-binding site 932677000840 dimer interface [polypeptide binding]; other site 932677000841 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932677000842 active site 932677000843 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 932677000844 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 932677000845 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 932677000846 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 932677000847 trimer interface [polypeptide binding]; other site 932677000848 eyelet of channel; other site 932677000849 gamma-glutamyl kinase; Provisional; Region: PRK05429 932677000850 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 932677000851 nucleotide binding site [chemical binding]; other site 932677000852 homotetrameric interface [polypeptide binding]; other site 932677000853 putative phosphate binding site [ion binding]; other site 932677000854 putative allosteric binding site; other site 932677000855 PUA domain; Region: PUA; pfam01472 932677000856 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 932677000857 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 932677000858 putative catalytic cysteine [active] 932677000859 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 932677000860 non-specific DNA binding site [nucleotide binding]; other site 932677000861 salt bridge; other site 932677000862 sequence-specific DNA binding site [nucleotide binding]; other site 932677000863 Predicted transcriptional regulator [Transcription]; Region: COG2932 932677000864 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 932677000865 Catalytic site [active] 932677000866 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 932677000867 catalytic residue [active] 932677000868 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 932677000869 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 932677000870 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 932677000871 [4Fe-4S] binding site [ion binding]; other site 932677000872 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 932677000873 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 932677000874 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 932677000875 molybdopterin cofactor binding site; other site 932677000876 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 932677000877 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 932677000878 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 932677000879 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 932677000880 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 932677000881 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 932677000882 PAS domain; Region: PAS; smart00091 932677000883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677000884 Walker A motif; other site 932677000885 ATP binding site [chemical binding]; other site 932677000886 Walker B motif; other site 932677000887 arginine finger; other site 932677000888 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 932677000889 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 932677000890 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 932677000891 dimer interface [polypeptide binding]; other site 932677000892 active site 932677000893 metal binding site [ion binding]; metal-binding site 932677000894 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 932677000895 Dak1 domain; Region: Dak1; pfam02733 932677000896 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 932677000897 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 932677000898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 932677000899 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 932677000900 dimerization domain swap beta strand [polypeptide binding]; other site 932677000901 regulatory protein interface [polypeptide binding]; other site 932677000902 active site 932677000903 regulatory phosphorylation site [posttranslational modification]; other site 932677000904 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 932677000905 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 932677000906 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 932677000907 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 932677000908 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 932677000909 haemagglutination activity domain; Region: Haemagg_act; pfam05860 932677000910 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 932677000911 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 932677000912 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 932677000913 Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; cl01763 932677000914 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677000915 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677000916 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 932677000917 putative substrate binding pocket [chemical binding]; other site 932677000918 putative dimerization interface [polypeptide binding]; other site 932677000919 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 932677000920 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 932677000921 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 932677000922 DNA-binding site [nucleotide binding]; DNA binding site 932677000923 RNA-binding motif; other site 932677000924 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 932677000925 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 932677000926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677000927 active site 932677000928 phosphorylation site [posttranslational modification] 932677000929 intermolecular recognition site; other site 932677000930 dimerization interface [polypeptide binding]; other site 932677000931 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 932677000932 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 932677000933 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 932677000934 ATP binding site [chemical binding]; other site 932677000935 Mg++ binding site [ion binding]; other site 932677000936 motif III; other site 932677000937 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932677000938 nucleotide binding region [chemical binding]; other site 932677000939 ATP-binding site [chemical binding]; other site 932677000940 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 932677000941 putative RNA binding site [nucleotide binding]; other site 932677000942 putative deaminase; Validated; Region: PRK06846 932677000943 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 932677000944 active site 932677000945 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677000946 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 932677000947 dimerization interface [polypeptide binding]; other site 932677000948 putative cyanate transporter; Provisional; Region: cynX; PRK09705 932677000949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677000950 putative substrate translocation pore; other site 932677000951 L-lactate permease; Provisional; Region: PRK10420 932677000952 glycolate transporter; Provisional; Region: PRK09695 932677000953 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 932677000954 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932677000955 DNA-binding site [nucleotide binding]; DNA binding site 932677000956 FCD domain; Region: FCD; pfam07729 932677000957 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 932677000958 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 932677000959 phosphate binding site [ion binding]; other site 932677000960 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 932677000961 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 932677000962 active site 932677000963 P-loop; other site 932677000964 phosphorylation site [posttranslational modification] 932677000965 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 932677000966 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932677000967 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 932677000968 active site 932677000969 methionine cluster; other site 932677000970 phosphorylation site [posttranslational modification] 932677000971 metal binding site [ion binding]; metal-binding site 932677000972 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 932677000973 beta-galactosidase; Region: BGL; TIGR03356 932677000974 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932677000975 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932677000976 DNA binding site [nucleotide binding] 932677000977 domain linker motif; other site 932677000978 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 932677000979 CAAX protease self-immunity; Region: Abi; pfam02517 932677000980 anti-RssB factor; Provisional; Region: PRK10244 932677000981 hypothetical protein; Provisional; Region: PRK11505 932677000982 psiF repeat; Region: PsiF_repeat; pfam07769 932677000983 psiF repeat; Region: PsiF_repeat; pfam07769 932677000984 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 932677000985 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932677000986 pyrroline-5-carboxylate reductase; Region: PLN02688 932677000987 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 932677000988 hypothetical protein; Validated; Region: PRK00124 932677000989 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 932677000990 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 932677000991 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 932677000992 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 932677000993 ADP binding site [chemical binding]; other site 932677000994 magnesium binding site [ion binding]; other site 932677000995 putative shikimate binding site; other site 932677000996 hypothetical protein; Provisional; Region: PRK10380 932677000997 hypothetical protein; Provisional; Region: PRK10579 932677000998 recombination associated protein; Reviewed; Region: rdgC; PRK00321 932677000999 fructokinase; Reviewed; Region: PRK09557 932677001000 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932677001001 nucleotide binding site [chemical binding]; other site 932677001002 TolA C-terminal; Region: TolA; pfam06519 932677001003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677001004 AAA domain; Region: AAA_23; pfam13476 932677001005 Walker A/P-loop; other site 932677001006 ATP binding site [chemical binding]; other site 932677001007 Q-loop/lid; other site 932677001008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677001009 ABC transporter signature motif; other site 932677001010 Walker B; other site 932677001011 D-loop; other site 932677001012 H-loop/switch region; other site 932677001013 exonuclease subunit SbcD; Provisional; Region: PRK10966 932677001014 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 932677001015 active site 932677001016 metal binding site [ion binding]; metal-binding site 932677001017 DNA binding site [nucleotide binding] 932677001018 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 932677001019 transcriptional regulator PhoB; Provisional; Region: PRK10161 932677001020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677001021 active site 932677001022 phosphorylation site [posttranslational modification] 932677001023 intermolecular recognition site; other site 932677001024 dimerization interface [polypeptide binding]; other site 932677001025 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932677001026 DNA binding site [nucleotide binding] 932677001027 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 932677001028 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 932677001029 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932677001030 putative active site [active] 932677001031 heme pocket [chemical binding]; other site 932677001032 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932677001033 dimer interface [polypeptide binding]; other site 932677001034 phosphorylation site [posttranslational modification] 932677001035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677001036 ATP binding site [chemical binding]; other site 932677001037 Mg2+ binding site [ion binding]; other site 932677001038 G-X-G motif; other site 932677001039 PBP superfamily domain; Region: PBP_like_2; cl17296 932677001040 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 932677001041 substrate binding site [chemical binding]; other site 932677001042 THF binding site; other site 932677001043 zinc-binding site [ion binding]; other site 932677001044 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 932677001045 putative proline-specific permease; Provisional; Region: proY; PRK10580 932677001046 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 932677001047 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 932677001048 catalytic core [active] 932677001049 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 932677001050 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 932677001051 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 932677001052 active site 932677001053 Protein of unknown function, DUF479; Region: DUF479; cl01203 932677001054 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 932677001055 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 932677001056 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 932677001057 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 932677001058 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 932677001059 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 932677001060 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 932677001061 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 932677001062 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 932677001063 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 932677001064 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 932677001065 Protein export membrane protein; Region: SecD_SecF; pfam02355 932677001066 hypothetical protein; Provisional; Region: PRK11530 932677001067 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 932677001068 ATP cone domain; Region: ATP-cone; pfam03477 932677001069 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 932677001070 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 932677001071 catalytic motif [active] 932677001072 Zn binding site [ion binding]; other site 932677001073 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 932677001074 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 932677001075 homopentamer interface [polypeptide binding]; other site 932677001076 active site 932677001077 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 932677001078 putative RNA binding site [nucleotide binding]; other site 932677001079 thiamine monophosphate kinase; Provisional; Region: PRK05731 932677001080 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 932677001081 ATP binding site [chemical binding]; other site 932677001082 dimerization interface [polypeptide binding]; other site 932677001083 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 932677001084 tetramer interfaces [polypeptide binding]; other site 932677001085 binuclear metal-binding site [ion binding]; other site 932677001086 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932677001087 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932677001088 active site 932677001089 catalytic tetrad [active] 932677001090 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 932677001091 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 932677001092 TPP-binding site; other site 932677001093 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 932677001094 PYR/PP interface [polypeptide binding]; other site 932677001095 dimer interface [polypeptide binding]; other site 932677001096 TPP binding site [chemical binding]; other site 932677001097 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 932677001098 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 932677001099 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 932677001100 substrate binding pocket [chemical binding]; other site 932677001101 chain length determination region; other site 932677001102 substrate-Mg2+ binding site; other site 932677001103 catalytic residues [active] 932677001104 aspartate-rich region 1; other site 932677001105 active site lid residues [active] 932677001106 aspartate-rich region 2; other site 932677001107 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 932677001108 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 932677001109 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 932677001110 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 932677001111 Ligand Binding Site [chemical binding]; other site 932677001112 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 932677001113 active site residue [active] 932677001114 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 932677001115 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 932677001116 conserved cys residue [active] 932677001117 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 932677001118 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 932677001119 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 932677001120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 932677001121 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 932677001122 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 932677001123 GAF domain; Region: GAF; pfam01590 932677001124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677001125 Walker A motif; other site 932677001126 ATP binding site [chemical binding]; other site 932677001127 Walker B motif; other site 932677001128 arginine finger; other site 932677001129 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 932677001130 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 932677001131 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 932677001132 NAD(P) binding site [chemical binding]; other site 932677001133 catalytic residues [active] 932677001134 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 932677001135 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 932677001136 NAD binding site [chemical binding]; other site 932677001137 substrate binding site [chemical binding]; other site 932677001138 catalytic Zn binding site [ion binding]; other site 932677001139 tetramer interface [polypeptide binding]; other site 932677001140 structural Zn binding site [ion binding]; other site 932677001141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677001142 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932677001143 putative substrate translocation pore; other site 932677001144 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 932677001145 UbiA prenyltransferase family; Region: UbiA; pfam01040 932677001146 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 932677001147 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 932677001148 Subunit I/III interface [polypeptide binding]; other site 932677001149 Subunit III/IV interface [polypeptide binding]; other site 932677001150 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 932677001151 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 932677001152 D-pathway; other site 932677001153 Putative ubiquinol binding site [chemical binding]; other site 932677001154 Low-spin heme (heme b) binding site [chemical binding]; other site 932677001155 Putative water exit pathway; other site 932677001156 Binuclear center (heme o3/CuB) [ion binding]; other site 932677001157 K-pathway; other site 932677001158 Putative proton exit pathway; other site 932677001159 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 932677001160 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 932677001161 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 932677001162 muropeptide transporter; Reviewed; Region: ampG; PRK11902 932677001163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677001164 putative substrate translocation pore; other site 932677001165 hypothetical protein; Provisional; Region: PRK11627 932677001166 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 932677001167 transcriptional regulator BolA; Provisional; Region: PRK11628 932677001168 trigger factor; Provisional; Region: tig; PRK01490 932677001169 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 932677001170 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 932677001171 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 932677001172 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 932677001173 oligomer interface [polypeptide binding]; other site 932677001174 active site residues [active] 932677001175 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 932677001176 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 932677001177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677001178 Walker A motif; other site 932677001179 ATP binding site [chemical binding]; other site 932677001180 Walker B motif; other site 932677001181 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 932677001182 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 932677001183 Found in ATP-dependent protease La (LON); Region: LON; smart00464 932677001184 Found in ATP-dependent protease La (LON); Region: LON; smart00464 932677001185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677001186 Walker A motif; other site 932677001187 ATP binding site [chemical binding]; other site 932677001188 Walker B motif; other site 932677001189 arginine finger; other site 932677001190 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 932677001191 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 932677001192 IHF dimer interface [polypeptide binding]; other site 932677001193 IHF - DNA interface [nucleotide binding]; other site 932677001194 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 932677001195 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 932677001196 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 932677001197 active site 932677001198 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 932677001199 Ligand Binding Site [chemical binding]; other site 932677001200 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 932677001201 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 932677001202 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932677001203 catalytic residue [active] 932677001204 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 932677001205 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932677001206 putative DNA binding site [nucleotide binding]; other site 932677001207 putative Zn2+ binding site [ion binding]; other site 932677001208 AsnC family; Region: AsnC_trans_reg; pfam01037 932677001209 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 932677001210 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932677001211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677001212 Walker A/P-loop; other site 932677001213 ATP binding site [chemical binding]; other site 932677001214 Q-loop/lid; other site 932677001215 ABC transporter signature motif; other site 932677001216 Walker B; other site 932677001217 D-loop; other site 932677001218 H-loop/switch region; other site 932677001219 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 932677001220 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932677001221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677001222 Walker A/P-loop; other site 932677001223 ATP binding site [chemical binding]; other site 932677001224 Q-loop/lid; other site 932677001225 ABC transporter signature motif; other site 932677001226 Walker B; other site 932677001227 D-loop; other site 932677001228 H-loop/switch region; other site 932677001229 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 932677001230 Nitrogen regulatory protein P-II; Region: P-II; smart00938 932677001231 ammonium transporter; Provisional; Region: PRK10666 932677001232 acyl-CoA thioesterase II; Provisional; Region: PRK10526 932677001233 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 932677001234 active site 932677001235 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 932677001236 catalytic triad [active] 932677001237 dimer interface [polypeptide binding]; other site 932677001238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 932677001239 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 932677001240 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 932677001241 DNA binding site [nucleotide binding] 932677001242 active site 932677001243 gene expression modulator; Provisional; Region: PRK10945 932677001244 Hha toxicity attenuator; Provisional; Region: PRK10667 932677001245 AAA domain; Region: AAA_23; pfam13476 932677001246 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 932677001247 ABC transporter; Region: ABC_tran; pfam00005 932677001248 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 932677001249 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932677001250 ABC-ATPase subunit interface; other site 932677001251 dimer interface [polypeptide binding]; other site 932677001252 putative PBP binding regions; other site 932677001253 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 932677001254 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 932677001255 metal binding site [ion binding]; metal-binding site 932677001256 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 932677001257 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 932677001258 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 932677001259 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 932677001260 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 932677001261 HlyD family secretion protein; Region: HlyD_3; pfam13437 932677001262 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 932677001263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932677001264 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 932677001265 hypothetical protein; Provisional; Region: PRK11038 932677001266 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 932677001267 hypothetical protein; Provisional; Region: PRK10527 932677001268 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932677001269 active site 932677001270 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 932677001271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677001272 Walker A motif; other site 932677001273 ATP binding site [chemical binding]; other site 932677001274 Walker B motif; other site 932677001275 arginine finger; other site 932677001276 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 932677001277 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 932677001278 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 932677001279 hypothetical protein; Validated; Region: PRK00153 932677001280 recombination protein RecR; Reviewed; Region: recR; PRK00076 932677001281 RecR protein; Region: RecR; pfam02132 932677001282 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 932677001283 putative active site [active] 932677001284 putative metal-binding site [ion binding]; other site 932677001285 tetramer interface [polypeptide binding]; other site 932677001286 heat shock protein 90; Provisional; Region: PRK05218 932677001287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677001288 ATP binding site [chemical binding]; other site 932677001289 Mg2+ binding site [ion binding]; other site 932677001290 G-X-G motif; other site 932677001291 adenylate kinase; Reviewed; Region: adk; PRK00279 932677001292 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 932677001293 AMP-binding site [chemical binding]; other site 932677001294 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 932677001295 inosine/guanosine kinase; Provisional; Region: PRK15074 932677001296 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 932677001297 putative cation:proton antiport protein; Provisional; Region: PRK10669 932677001298 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 932677001299 TrkA-N domain; Region: TrkA_N; pfam02254 932677001300 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 932677001301 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 932677001302 active site 932677001303 metal binding site [ion binding]; metal-binding site 932677001304 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 932677001305 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677001306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677001307 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 932677001308 dimerization interface [polypeptide binding]; other site 932677001309 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 932677001310 putative deacylase active site [active] 932677001311 TraB family; Region: TraB; cl12050 932677001312 copper exporting ATPase; Provisional; Region: copA; PRK10671 932677001313 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 932677001314 metal-binding site [ion binding] 932677001315 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 932677001316 metal-binding site [ion binding] 932677001317 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 932677001318 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677001319 motif II; other site 932677001320 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 932677001321 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 932677001322 DNA binding residues [nucleotide binding] 932677001323 dimer interface [polypeptide binding]; other site 932677001324 copper binding site [ion binding]; other site 932677001325 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 932677001326 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 932677001327 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 932677001328 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 932677001329 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 932677001330 oxidoreductase; Provisional; Region: PRK08017 932677001331 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 932677001332 NADP binding site [chemical binding]; other site 932677001333 active site 932677001334 steroid binding site; other site 932677001335 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 932677001336 active site 932677001337 catalytic triad [active] 932677001338 oxyanion hole [active] 932677001339 switch loop; other site 932677001340 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 932677001341 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932677001342 Walker A/P-loop; other site 932677001343 ATP binding site [chemical binding]; other site 932677001344 Q-loop/lid; other site 932677001345 ABC transporter signature motif; other site 932677001346 Walker B; other site 932677001347 D-loop; other site 932677001348 H-loop/switch region; other site 932677001349 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 932677001350 FtsX-like permease family; Region: FtsX; pfam02687 932677001351 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 932677001352 ATP-grasp domain; Region: ATP-grasp; pfam02222 932677001353 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 932677001354 Predicted membrane protein [Function unknown]; Region: COG4325 932677001355 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 932677001356 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 932677001357 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 932677001358 putative active site [active] 932677001359 putative metal binding site [ion binding]; other site 932677001360 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 932677001361 substrate binding site [chemical binding]; other site 932677001362 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 932677001363 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 932677001364 active site 932677001365 HIGH motif; other site 932677001366 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 932677001367 KMSKS motif; other site 932677001368 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 932677001369 tRNA binding surface [nucleotide binding]; other site 932677001370 anticodon binding site; other site 932677001371 Predicted ATPase [General function prediction only]; Region: COG4637 932677001372 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677001373 Walker A/P-loop; other site 932677001374 ATP binding site [chemical binding]; other site 932677001375 ribosome-associated protein; Provisional; Region: PRK11507 932677001376 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 932677001377 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 932677001378 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 932677001379 homodimer interface [polypeptide binding]; other site 932677001380 NADP binding site [chemical binding]; other site 932677001381 substrate binding site [chemical binding]; other site 932677001382 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 932677001383 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 932677001384 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 932677001385 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 932677001386 Ligand binding site; other site 932677001387 Putative Catalytic site; other site 932677001388 DXD motif; other site 932677001389 Predicted membrane protein [Function unknown]; Region: COG2246 932677001390 GtrA-like protein; Region: GtrA; pfam04138 932677001391 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 932677001392 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 932677001393 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 932677001394 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 932677001395 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 932677001396 haemagglutination activity domain; Region: Haemagg_act; pfam05860 932677001397 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 932677001398 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 932677001399 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 932677001400 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 932677001401 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 932677001402 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 932677001403 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 932677001404 HTH-like domain; Region: HTH_21; pfam13276 932677001405 PAAR motif; Region: PAAR_motif; pfam05488 932677001406 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 932677001407 RHS Repeat; Region: RHS_repeat; pfam05593 932677001408 RHS Repeat; Region: RHS_repeat; cl11982 932677001409 RHS Repeat; Region: RHS_repeat; cl11982 932677001410 RHS protein; Region: RHS; pfam03527 932677001411 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 932677001412 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 932677001413 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 932677001414 peptide binding site [polypeptide binding]; other site 932677001415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 932677001416 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 932677001417 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 932677001418 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 932677001419 hexamer (dimer of trimers) interface [polypeptide binding]; other site 932677001420 substrate binding site [chemical binding]; other site 932677001421 trimer interface [polypeptide binding]; other site 932677001422 Mn binding site [ion binding]; other site 932677001423 putative symporter YagG; Provisional; Region: PRK09669 932677001424 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 932677001425 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 932677001426 hypothetical protein; Provisional; Region: PRK09897 932677001427 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 932677001428 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 932677001429 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 932677001430 Autotransporter beta-domain; Region: Autotransporter; pfam03797 932677001431 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 932677001432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677001433 putative substrate translocation pore; other site 932677001434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677001435 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 932677001436 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 932677001437 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 932677001438 PapC N-terminal domain; Region: PapC_N; pfam13954 932677001439 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 932677001440 PapC C-terminal domain; Region: PapC_C; pfam13953 932677001441 putative periplasmic fimbrial chaperone protein SteC; Provisional; Region: PRK15274 932677001442 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 932677001443 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 932677001444 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 932677001445 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 932677001446 Fimbrial protein; Region: Fimbrial; pfam00419 932677001447 EAL domain; Region: EAL; pfam00563 932677001448 Methyltransferase domain; Region: Methyltransf_31; pfam13847 932677001449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677001450 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 932677001451 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 932677001452 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 932677001453 putative lipid kinase; Reviewed; Region: PRK13057 932677001454 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 932677001455 Domain of unknown function DUF20; Region: UPF0118; pfam01594 932677001456 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 932677001457 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 932677001458 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 932677001459 active site 932677001460 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 932677001461 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 932677001462 NAD binding site [chemical binding]; other site 932677001463 catalytic Zn binding site [ion binding]; other site 932677001464 structural Zn binding site [ion binding]; other site 932677001465 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 932677001466 serine transporter; Region: stp; TIGR00814 932677001467 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 932677001468 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 932677001469 intersubunit interface [polypeptide binding]; other site 932677001470 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 932677001471 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 932677001472 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677001473 active site 932677001474 motif I; other site 932677001475 motif II; other site 932677001476 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677001477 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 932677001478 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 932677001479 active site 932677001480 NAD binding site [chemical binding]; other site 932677001481 metal binding site [ion binding]; metal-binding site 932677001482 high-affinity gluconate transporter; Provisional; Region: PRK14984 932677001483 gluconate transporter; Region: gntP; TIGR00791 932677001484 potential protein location (hypothetical protein) that overlaps protein (high-affinity gluconate transporter GntT) 932677001485 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 932677001486 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 932677001487 DNA-binding site [nucleotide binding]; DNA binding site 932677001488 RNA-binding motif; other site 932677001489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677001490 Coenzyme A binding pocket [chemical binding]; other site 932677001491 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 932677001492 Predicted amidohydrolase [General function prediction only]; Region: COG0388 932677001493 putative active site [active] 932677001494 catalytic triad [active] 932677001495 putative dimer interface [polypeptide binding]; other site 932677001496 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 932677001497 lipoyl synthase; Provisional; Region: PRK05481 932677001498 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 932677001499 FeS/SAM binding site; other site 932677001500 lipoate-protein ligase B; Provisional; Region: PRK14342 932677001501 hypothetical protein; Provisional; Region: PRK04998 932677001502 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 932677001503 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 932677001504 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 932677001505 rare lipoprotein A; Provisional; Region: PRK10672 932677001506 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 932677001507 Sporulation related domain; Region: SPOR; pfam05036 932677001508 cell wall shape-determining protein; Provisional; Region: PRK10794 932677001509 penicillin-binding protein 2; Provisional; Region: PRK10795 932677001510 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 932677001511 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 932677001512 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 932677001513 ribosome-associated protein; Provisional; Region: PRK11538 932677001514 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 932677001515 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 932677001516 active site 932677001517 (T/H)XGH motif; other site 932677001518 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 932677001519 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 932677001520 Lipopolysaccharide-assembly; Region: LptE; cl01125 932677001521 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 932677001522 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 932677001523 HIGH motif; other site 932677001524 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 932677001525 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 932677001526 active site 932677001527 KMSKS motif; other site 932677001528 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 932677001529 tRNA binding surface [nucleotide binding]; other site 932677001530 hypothetical protein; Provisional; Region: PRK11032 932677001531 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 932677001532 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 932677001533 Walker A/P-loop; other site 932677001534 ATP binding site [chemical binding]; other site 932677001535 Q-loop/lid; other site 932677001536 ABC transporter signature motif; other site 932677001537 Walker B; other site 932677001538 D-loop; other site 932677001539 H-loop/switch region; other site 932677001540 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 932677001541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677001542 dimer interface [polypeptide binding]; other site 932677001543 conserved gate region; other site 932677001544 putative PBP binding loops; other site 932677001545 ABC-ATPase subunit interface; other site 932677001546 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 932677001547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677001548 dimer interface [polypeptide binding]; other site 932677001549 conserved gate region; other site 932677001550 putative PBP binding loops; other site 932677001551 ABC-ATPase subunit interface; other site 932677001552 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 932677001553 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677001554 substrate binding pocket [chemical binding]; other site 932677001555 membrane-bound complex binding site; other site 932677001556 hinge residues; other site 932677001557 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 932677001558 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 932677001559 putative active site [active] 932677001560 catalytic triad [active] 932677001561 putative dimer interface [polypeptide binding]; other site 932677001562 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 932677001563 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 932677001564 Transporter associated domain; Region: CorC_HlyC; smart01091 932677001565 metal-binding heat shock protein; Provisional; Region: PRK00016 932677001566 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 932677001567 PhoH-like protein; Region: PhoH; pfam02562 932677001568 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 932677001569 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 932677001570 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 932677001571 FeS/SAM binding site; other site 932677001572 TRAM domain; Region: TRAM; pfam01938 932677001573 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 932677001574 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 932677001575 asparagine synthetase B; Provisional; Region: asnB; PRK09431 932677001576 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 932677001577 active site 932677001578 dimer interface [polypeptide binding]; other site 932677001579 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 932677001580 Ligand Binding Site [chemical binding]; other site 932677001581 Molecular Tunnel; other site 932677001582 UMP phosphatase; Provisional; Region: PRK10444 932677001583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677001584 active site 932677001585 motif I; other site 932677001586 motif II; other site 932677001587 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677001588 MarR family; Region: MarR; pfam01047 932677001589 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932677001590 ROK family; Region: ROK; pfam00480 932677001591 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 932677001592 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 932677001593 active site 932677001594 dimer interface [polypeptide binding]; other site 932677001595 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 932677001596 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 932677001597 active site 932677001598 trimer interface [polypeptide binding]; other site 932677001599 allosteric site; other site 932677001600 active site lid [active] 932677001601 hexamer (dimer of trimers) interface [polypeptide binding]; other site 932677001602 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 932677001603 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 932677001604 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 932677001605 active site turn [active] 932677001606 phosphorylation site [posttranslational modification] 932677001607 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 932677001608 HPr interaction site; other site 932677001609 glycerol kinase (GK) interaction site [polypeptide binding]; other site 932677001610 active site 932677001611 phosphorylation site [posttranslational modification] 932677001612 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 932677001613 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 932677001614 active site 932677001615 HIGH motif; other site 932677001616 nucleotide binding site [chemical binding]; other site 932677001617 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 932677001618 KMSKS motif; other site 932677001619 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 932677001620 ferric uptake regulator; Provisional; Region: fur; PRK09462 932677001621 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 932677001622 metal binding site 2 [ion binding]; metal-binding site 932677001623 putative DNA binding helix; other site 932677001624 metal binding site 1 [ion binding]; metal-binding site 932677001625 dimer interface [polypeptide binding]; other site 932677001626 structural Zn2+ binding site [ion binding]; other site 932677001627 flavodoxin FldA; Validated; Region: PRK09267 932677001628 LexA regulated protein; Provisional; Region: PRK11675 932677001629 acyl-CoA esterase; Provisional; Region: PRK10673 932677001630 PGAP1-like protein; Region: PGAP1; pfam07819 932677001631 replication initiation regulator SeqA; Provisional; Region: PRK11187 932677001632 phosphoglucomutase; Validated; Region: PRK07564 932677001633 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 932677001634 active site 932677001635 substrate binding site [chemical binding]; other site 932677001636 metal binding site [ion binding]; metal-binding site 932677001637 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 932677001638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677001639 active site 932677001640 phosphorylation site [posttranslational modification] 932677001641 intermolecular recognition site; other site 932677001642 dimerization interface [polypeptide binding]; other site 932677001643 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932677001644 DNA binding site [nucleotide binding] 932677001645 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 932677001646 Protein of unknown function (DUF523); Region: DUF523; pfam04463 932677001647 Uncharacterized conserved protein [Function unknown]; Region: COG3272 932677001648 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 932677001649 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 932677001650 DNA photolyase; Region: DNA_photolyase; pfam00875 932677001651 Uncharacterized conserved protein [Function unknown]; Region: COG0327 932677001652 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 932677001653 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 932677001654 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 932677001655 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 932677001656 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 932677001657 putative active site [active] 932677001658 Protein of unknown function (DUF969); Region: DUF969; pfam06149 932677001659 Predicted membrane protein [Function unknown]; Region: COG3817 932677001660 Protein of unknown function (DUF979); Region: DUF979; pfam06166 932677001661 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 932677001662 putative substrate binding pocket [chemical binding]; other site 932677001663 AC domain interface; other site 932677001664 catalytic triad [active] 932677001665 AB domain interface; other site 932677001666 interchain disulfide; other site 932677001667 endonuclease VIII; Provisional; Region: PRK10445 932677001668 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 932677001669 DNA binding site [nucleotide binding] 932677001670 catalytic residue [active] 932677001671 H2TH interface [polypeptide binding]; other site 932677001672 putative catalytic residues [active] 932677001673 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 932677001674 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 932677001675 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 932677001676 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 932677001677 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 932677001678 dimer interface [polypeptide binding]; other site 932677001679 active site 932677001680 citrylCoA binding site [chemical binding]; other site 932677001681 NADH binding [chemical binding]; other site 932677001682 cationic pore residues; other site 932677001683 oxalacetate/citrate binding site [chemical binding]; other site 932677001684 coenzyme A binding site [chemical binding]; other site 932677001685 catalytic triad [active] 932677001686 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 932677001687 Iron-sulfur protein interface; other site 932677001688 proximal quinone binding site [chemical binding]; other site 932677001689 SdhD (CybS) interface [polypeptide binding]; other site 932677001690 proximal heme binding site [chemical binding]; other site 932677001691 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 932677001692 cardiolipin binding site; other site 932677001693 SdhC subunit interface [polypeptide binding]; other site 932677001694 proximal heme binding site [chemical binding]; other site 932677001695 Iron-sulfur protein interface; other site 932677001696 proximal quinone binding site [chemical binding]; other site 932677001697 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 932677001698 L-aspartate oxidase; Provisional; Region: PRK06175 932677001699 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 932677001700 potential protein location (conserved hypothetical protein conserved hypothetical protein) that overlaps protein (succinate dehydrogenase flavoprotein subunit SdhA) 932677001701 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 932677001702 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 932677001703 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 932677001704 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 932677001705 TPP-binding site [chemical binding]; other site 932677001706 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 932677001707 dimer interface [polypeptide binding]; other site 932677001708 PYR/PP interface [polypeptide binding]; other site 932677001709 TPP binding site [chemical binding]; other site 932677001710 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 932677001711 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 932677001712 E3 interaction surface; other site 932677001713 lipoyl attachment site [posttranslational modification]; other site 932677001714 e3 binding domain; Region: E3_binding; pfam02817 932677001715 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 932677001716 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 932677001717 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 932677001718 CoA-ligase; Region: Ligase_CoA; pfam00549 932677001719 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 932677001720 CoA binding domain; Region: CoA_binding; pfam02629 932677001721 CoA-ligase; Region: Ligase_CoA; pfam00549 932677001722 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 932677001723 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 932677001724 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 932677001725 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 932677001726 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 932677001727 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 932677001728 active site 932677001729 colicin uptake protein TolQ; Provisional; Region: PRK10801 932677001730 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 932677001731 colicin uptake protein TolR; Provisional; Region: PRK11024 932677001732 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 932677001733 TolA C-terminal; Region: TolA; pfam06519 932677001734 translocation protein TolB; Provisional; Region: tolB; PRK03629 932677001735 TolB amino-terminal domain; Region: TolB_N; pfam04052 932677001736 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 932677001737 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 932677001738 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 932677001739 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 932677001740 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 932677001741 ligand binding site [chemical binding]; other site 932677001742 tol-pal system protein YbgF; Provisional; Region: PRK10803 932677001743 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932677001744 TPR motif; other site 932677001745 binding surface 932677001746 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 932677001747 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932677001748 dimerization interface [polypeptide binding]; other site 932677001749 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677001750 dimer interface [polypeptide binding]; other site 932677001751 putative CheW interface [polypeptide binding]; other site 932677001752 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 932677001753 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 932677001754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677001755 AlkA N-terminal domain; Region: AlkA_N; pfam06029 932677001756 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 932677001757 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 932677001758 minor groove reading motif; other site 932677001759 helix-hairpin-helix signature motif; other site 932677001760 substrate binding pocket [chemical binding]; other site 932677001761 active site 932677001762 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 932677001763 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 932677001764 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 932677001765 DNA binding site [nucleotide binding] 932677001766 active site 932677001767 quinolinate synthetase; Provisional; Region: PRK09375 932677001768 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 932677001769 zinc transporter ZitB; Provisional; Region: PRK03557 932677001770 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 932677001771 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677001772 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 932677001773 substrate binding pocket [chemical binding]; other site 932677001774 membrane-bound complex binding site; other site 932677001775 hinge residues; other site 932677001776 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932677001777 dimer interface [polypeptide binding]; other site 932677001778 phosphorylation site [posttranslational modification] 932677001779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677001780 ATP binding site [chemical binding]; other site 932677001781 Mg2+ binding site [ion binding]; other site 932677001782 G-X-G motif; other site 932677001783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677001784 active site 932677001785 phosphorylation site [posttranslational modification] 932677001786 intermolecular recognition site; other site 932677001787 Hpt domain; Region: Hpt; pfam01627 932677001788 putative binding surface; other site 932677001789 active site 932677001790 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 932677001791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677001792 active site 932677001793 phosphorylation site [posttranslational modification] 932677001794 intermolecular recognition site; other site 932677001795 dimerization interface [polypeptide binding]; other site 932677001796 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 932677001797 DNA binding residues [nucleotide binding] 932677001798 dimerization interface [polypeptide binding]; other site 932677001799 YbgS-like protein; Region: YbgS; pfam13985 932677001800 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 932677001801 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 932677001802 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932677001803 catalytic core [active] 932677001804 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932677001805 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 932677001806 active site 932677001807 catalytic residues [active] 932677001808 galactokinase; Provisional; Region: PRK05101 932677001809 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 932677001810 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 932677001811 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 932677001812 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 932677001813 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 932677001814 dimer interface [polypeptide binding]; other site 932677001815 active site 932677001816 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 932677001817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677001818 Walker A/P-loop; other site 932677001819 ATP binding site [chemical binding]; other site 932677001820 Q-loop/lid; other site 932677001821 ABC transporter signature motif; other site 932677001822 Walker B; other site 932677001823 D-loop; other site 932677001824 H-loop/switch region; other site 932677001825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677001826 Walker A/P-loop; other site 932677001827 ATP binding site [chemical binding]; other site 932677001828 Q-loop/lid; other site 932677001829 ABC transporter signature motif; other site 932677001830 Walker B; other site 932677001831 D-loop; other site 932677001832 H-loop/switch region; other site 932677001833 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 932677001834 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 932677001835 molybdenum-pterin binding domain; Region: Mop; TIGR00638 932677001836 TOBE domain; Region: TOBE; cl01440 932677001837 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 932677001838 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 932677001839 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 932677001840 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 932677001841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677001842 dimer interface [polypeptide binding]; other site 932677001843 conserved gate region; other site 932677001844 putative PBP binding loops; other site 932677001845 ABC-ATPase subunit interface; other site 932677001846 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 932677001847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677001848 Walker A/P-loop; other site 932677001849 ATP binding site [chemical binding]; other site 932677001850 Q-loop/lid; other site 932677001851 ABC transporter signature motif; other site 932677001852 Walker B; other site 932677001853 D-loop; other site 932677001854 H-loop/switch region; other site 932677001855 molybdenum-pterin binding domain; Region: Mop; TIGR00638 932677001856 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 932677001857 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677001858 active site 932677001859 motif I; other site 932677001860 motif II; other site 932677001861 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 932677001862 6-phosphogluconolactonase; Provisional; Region: PRK11028 932677001863 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 932677001864 substrate binding site [chemical binding]; other site 932677001865 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 932677001866 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 932677001867 inhibitor-cofactor binding pocket; inhibition site 932677001868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677001869 catalytic residue [active] 932677001870 biotin synthase; Provisional; Region: PRK15108 932677001871 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 932677001872 FeS/SAM binding site; other site 932677001873 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 932677001874 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 932677001875 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 932677001876 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932677001877 catalytic residue [active] 932677001878 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 932677001879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677001880 S-adenosylmethionine binding site [chemical binding]; other site 932677001881 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 932677001882 AAA domain; Region: AAA_26; pfam13500 932677001883 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 932677001884 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 932677001885 Walker A/P-loop; other site 932677001886 ATP binding site [chemical binding]; other site 932677001887 Q-loop/lid; other site 932677001888 ABC transporter signature motif; other site 932677001889 Walker B; other site 932677001890 D-loop; other site 932677001891 H-loop/switch region; other site 932677001892 excinuclease ABC subunit B; Provisional; Region: PRK05298 932677001893 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932677001894 ATP binding site [chemical binding]; other site 932677001895 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932677001896 nucleotide binding region [chemical binding]; other site 932677001897 ATP-binding site [chemical binding]; other site 932677001898 Ultra-violet resistance protein B; Region: UvrB; pfam12344 932677001899 UvrB/uvrC motif; Region: UVR; pfam02151 932677001900 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 932677001901 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 932677001902 phosphate binding site [ion binding]; other site 932677001903 putative substrate binding pocket [chemical binding]; other site 932677001904 dimer interface [polypeptide binding]; other site 932677001905 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 932677001906 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 932677001907 MPT binding site; other site 932677001908 trimer interface [polypeptide binding]; other site 932677001909 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 932677001910 trimer interface [polypeptide binding]; other site 932677001911 dimer interface [polypeptide binding]; other site 932677001912 putative active site [active] 932677001913 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 932677001914 MoaE interaction surface [polypeptide binding]; other site 932677001915 MoeB interaction surface [polypeptide binding]; other site 932677001916 thiocarboxylated glycine; other site 932677001917 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 932677001918 MoaE homodimer interface [polypeptide binding]; other site 932677001919 MoaD interaction [polypeptide binding]; other site 932677001920 active site residues [active] 932677001921 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 932677001922 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 932677001923 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 932677001924 Predicted integral membrane protein [Function unknown]; Region: COG0392 932677001925 cardiolipin synthase 2; Provisional; Region: PRK11263 932677001926 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 932677001927 putative active site [active] 932677001928 catalytic site [active] 932677001929 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 932677001930 putative active site [active] 932677001931 catalytic site [active] 932677001932 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 932677001933 putative catalytic site [active] 932677001934 putative metal binding site [ion binding]; other site 932677001935 putative phosphate binding site [ion binding]; other site 932677001936 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 932677001937 helicase 45; Provisional; Region: PTZ00424 932677001938 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 932677001939 ATP binding site [chemical binding]; other site 932677001940 Mg++ binding site [ion binding]; other site 932677001941 motif III; other site 932677001942 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932677001943 nucleotide binding region [chemical binding]; other site 932677001944 ATP-binding site [chemical binding]; other site 932677001945 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 932677001946 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 932677001947 FMN binding site [chemical binding]; other site 932677001948 active site 932677001949 catalytic residues [active] 932677001950 substrate binding site [chemical binding]; other site 932677001951 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 932677001952 potential protein location (hypothetical protein) that overlaps protein (RNA polymerase sigma factor) 932677001953 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 932677001954 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 932677001955 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 932677001956 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 932677001957 Cl binding site [ion binding]; other site 932677001958 oligomer interface [polypeptide binding]; other site 932677001959 L,D-transpeptidase; Provisional; Region: PRK10260 932677001960 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 932677001961 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 932677001962 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 932677001963 oxidoreductase; Provisional; Region: PRK12743 932677001964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932677001965 NAD(P) binding site [chemical binding]; other site 932677001966 active site 932677001967 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 932677001968 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 932677001969 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 932677001970 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 932677001971 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 932677001972 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 932677001973 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 932677001974 Mechanosensitive ion channel; Region: MS_channel; pfam00924 932677001975 D-lactate dehydrogenase; Provisional; Region: PRK11183 932677001976 FAD binding domain; Region: FAD_binding_4; pfam01565 932677001977 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 932677001978 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 932677001979 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 932677001980 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 932677001981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932677001982 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 932677001983 HAMP domain; Region: HAMP; pfam00672 932677001984 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 932677001985 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677001986 dimer interface [polypeptide binding]; other site 932677001987 putative CheW interface [polypeptide binding]; other site 932677001988 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 932677001989 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 932677001990 active site 932677001991 metal binding site [ion binding]; metal-binding site 932677001992 nudix motif; other site 932677001993 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 932677001994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677001995 dimer interface [polypeptide binding]; other site 932677001996 conserved gate region; other site 932677001997 ABC-ATPase subunit interface; other site 932677001998 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 932677001999 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 932677002000 Walker A/P-loop; other site 932677002001 ATP binding site [chemical binding]; other site 932677002002 Q-loop/lid; other site 932677002003 ABC transporter signature motif; other site 932677002004 Walker B; other site 932677002005 D-loop; other site 932677002006 H-loop/switch region; other site 932677002007 CBS domain; Region: CBS; pfam00571 932677002008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677002009 putative PBP binding loops; other site 932677002010 dimer interface [polypeptide binding]; other site 932677002011 ABC-ATPase subunit interface; other site 932677002012 transcriptional regulator MirA; Provisional; Region: PRK15043 932677002013 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 932677002014 DNA binding residues [nucleotide binding] 932677002015 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 932677002016 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932677002017 non-specific DNA binding site [nucleotide binding]; other site 932677002018 salt bridge; other site 932677002019 sequence-specific DNA binding site [nucleotide binding]; other site 932677002020 Cupin domain; Region: Cupin_2; cl17218 932677002021 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677002022 Coenzyme A binding pocket [chemical binding]; other site 932677002023 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 932677002024 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 932677002025 DEAD_2; Region: DEAD_2; pfam06733 932677002026 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 932677002027 glycosyl transferase family protein; Provisional; Region: PRK08136 932677002028 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 932677002029 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 932677002030 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 932677002031 metal binding site [ion binding]; metal-binding site 932677002032 putative dimer interface [polypeptide binding]; other site 932677002033 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932677002034 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932677002035 DNA binding site [nucleotide binding] 932677002036 domain linker motif; other site 932677002037 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 932677002038 putative dimerization interface [polypeptide binding]; other site 932677002039 putative ligand binding site [chemical binding]; other site 932677002040 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 932677002041 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 932677002042 active site pocket [active] 932677002043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677002044 D-galactonate transporter; Region: 2A0114; TIGR00893 932677002045 putative substrate translocation pore; other site 932677002046 urocanate hydratase; Provisional; Region: PRK05414 932677002047 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 932677002048 active sites [active] 932677002049 tetramer interface [polypeptide binding]; other site 932677002050 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 932677002051 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932677002052 DNA-binding site [nucleotide binding]; DNA binding site 932677002053 UTRA domain; Region: UTRA; pfam07702 932677002054 HutD; Region: HutD; pfam05962 932677002055 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 932677002056 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 932677002057 active site 932677002058 imidazolonepropionase; Validated; Region: PRK09356 932677002059 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 932677002060 active site 932677002061 N-formylglutamate amidohydrolase; Region: FGase; cl01522 932677002062 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 932677002063 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677002064 substrate binding pocket [chemical binding]; other site 932677002065 membrane-bound complex binding site; other site 932677002066 hinge residues; other site 932677002067 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 932677002068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677002069 dimer interface [polypeptide binding]; other site 932677002070 conserved gate region; other site 932677002071 putative PBP binding loops; other site 932677002072 ABC-ATPase subunit interface; other site 932677002073 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 932677002074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677002075 dimer interface [polypeptide binding]; other site 932677002076 conserved gate region; other site 932677002077 putative PBP binding loops; other site 932677002078 ABC-ATPase subunit interface; other site 932677002079 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 932677002080 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 932677002081 Walker A/P-loop; other site 932677002082 ATP binding site [chemical binding]; other site 932677002083 Q-loop/lid; other site 932677002084 ABC transporter signature motif; other site 932677002085 Walker B; other site 932677002086 D-loop; other site 932677002087 H-loop/switch region; other site 932677002088 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 932677002089 active sites [active] 932677002090 tetramer interface [polypeptide binding]; other site 932677002091 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 932677002092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932677002093 NAD(P) binding site [chemical binding]; other site 932677002094 active site 932677002095 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 932677002096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677002097 S-adenosylmethionine binding site [chemical binding]; other site 932677002098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677002099 Q-loop/lid; other site 932677002100 ABC transporter signature motif; other site 932677002101 Walker B; other site 932677002102 D-loop; other site 932677002103 H-loop/switch region; other site 932677002104 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 932677002105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677002106 dimer interface [polypeptide binding]; other site 932677002107 conserved gate region; other site 932677002108 putative PBP binding loops; other site 932677002109 ABC-ATPase subunit interface; other site 932677002110 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 932677002111 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677002112 substrate binding pocket [chemical binding]; other site 932677002113 membrane-bound complex binding site; other site 932677002114 hinge residues; other site 932677002115 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 932677002116 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 932677002117 dimerization interface [polypeptide binding]; other site 932677002118 DPS ferroxidase diiron center [ion binding]; other site 932677002119 ion pore; other site 932677002120 threonine and homoserine efflux system; Provisional; Region: PRK10532 932677002121 EamA-like transporter family; Region: EamA; pfam00892 932677002122 outer membrane protein X; Provisional; Region: ompX; PRK09408 932677002123 manganese transport regulator MntR; Provisional; Region: PRK11050 932677002124 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 932677002125 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 932677002126 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 932677002127 transmembrane helices; other site 932677002128 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 932677002129 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 932677002130 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 932677002131 HlyD family secretion protein; Region: HlyD_3; pfam13437 932677002132 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 932677002133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677002134 putative substrate translocation pore; other site 932677002135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677002136 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 932677002137 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 932677002138 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 932677002139 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 932677002140 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677002141 Walker A/P-loop; other site 932677002142 ATP binding site [chemical binding]; other site 932677002143 Q-loop/lid; other site 932677002144 ABC transporter signature motif; other site 932677002145 Walker B; other site 932677002146 D-loop; other site 932677002147 H-loop/switch region; other site 932677002148 ABC transporter; Region: ABC_tran_2; pfam12848 932677002149 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932677002150 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 932677002151 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 932677002152 ATP binding site [chemical binding]; other site 932677002153 substrate interface [chemical binding]; other site 932677002154 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 932677002155 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 932677002156 dimer interface [polypeptide binding]; other site 932677002157 putative functional site; other site 932677002158 putative MPT binding site; other site 932677002159 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 932677002160 catalytic nucleophile [active] 932677002161 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 932677002162 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932677002163 Walker A/P-loop; other site 932677002164 ATP binding site [chemical binding]; other site 932677002165 Q-loop/lid; other site 932677002166 ABC transporter signature motif; other site 932677002167 Walker B; other site 932677002168 D-loop; other site 932677002169 H-loop/switch region; other site 932677002170 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 932677002171 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932677002172 Walker A/P-loop; other site 932677002173 ATP binding site [chemical binding]; other site 932677002174 Q-loop/lid; other site 932677002175 ABC transporter signature motif; other site 932677002176 Walker B; other site 932677002177 D-loop; other site 932677002178 H-loop/switch region; other site 932677002179 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 932677002180 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 932677002181 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 932677002182 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 932677002183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677002184 dimer interface [polypeptide binding]; other site 932677002185 conserved gate region; other site 932677002186 putative PBP binding loops; other site 932677002187 ABC-ATPase subunit interface; other site 932677002188 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 932677002189 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 932677002190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677002191 dimer interface [polypeptide binding]; other site 932677002192 conserved gate region; other site 932677002193 putative PBP binding loops; other site 932677002194 ABC-ATPase subunit interface; other site 932677002195 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 932677002196 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 932677002197 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 932677002198 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 932677002199 FeS/SAM binding site; other site 932677002200 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 932677002201 active site clefts [active] 932677002202 zinc binding site [ion binding]; other site 932677002203 dimer interface [polypeptide binding]; other site 932677002204 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 932677002205 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 932677002206 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 932677002207 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 932677002208 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 932677002209 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 932677002210 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 932677002211 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 932677002212 active site 932677002213 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 932677002214 putative transporter; Provisional; Region: PRK04972 932677002215 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 932677002216 TrkA-C domain; Region: TrkA_C; pfam02080 932677002217 TrkA-C domain; Region: TrkA_C; pfam02080 932677002218 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 932677002219 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 932677002220 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 932677002221 GSH binding site [chemical binding]; other site 932677002222 catalytic residues [active] 932677002223 Protein of unknown function (DUF1418); Region: DUF1418; cl11648 932677002224 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 932677002225 dimer interface [polypeptide binding]; other site 932677002226 FMN binding site [chemical binding]; other site 932677002227 NADPH bind site [chemical binding]; other site 932677002228 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 932677002229 RimK-like ATP-grasp domain; Region: RimK; pfam08443 932677002230 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 932677002231 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 932677002232 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 932677002233 spermidine/putrescine ABC transporter ATP-binding subunit; Region: potA; TIGR01187 932677002234 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677002235 Q-loop/lid; other site 932677002236 ABC transporter signature motif; other site 932677002237 Walker B; other site 932677002238 D-loop; other site 932677002239 H-loop/switch region; other site 932677002240 TOBE domain; Region: TOBE_2; pfam08402 932677002241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677002242 dimer interface [polypeptide binding]; other site 932677002243 conserved gate region; other site 932677002244 putative PBP binding loops; other site 932677002245 ABC-ATPase subunit interface; other site 932677002246 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 932677002247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677002248 dimer interface [polypeptide binding]; other site 932677002249 conserved gate region; other site 932677002250 putative PBP binding loops; other site 932677002251 ABC-ATPase subunit interface; other site 932677002252 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 932677002253 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 932677002254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677002255 S-adenosylmethionine binding site [chemical binding]; other site 932677002256 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 932677002257 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677002258 substrate binding pocket [chemical binding]; other site 932677002259 membrane-bound complex binding site; other site 932677002260 hinge residues; other site 932677002261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677002262 dimer interface [polypeptide binding]; other site 932677002263 conserved gate region; other site 932677002264 putative PBP binding loops; other site 932677002265 ABC-ATPase subunit interface; other site 932677002266 potential frameshift: common BLAST hit: gi|378767918|ref|YP_005196388.1| arginine transporter permease subunit ArtQ 932677002267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677002268 dimer interface [polypeptide binding]; other site 932677002269 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 932677002270 ABC-ATPase subunit interface; other site 932677002271 putative PBP binding loops; other site 932677002272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677002273 conserved gate region; other site 932677002274 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 932677002275 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677002276 substrate binding pocket [chemical binding]; other site 932677002277 membrane-bound complex binding site; other site 932677002278 hinge residues; other site 932677002279 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 932677002280 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677002281 Walker A/P-loop; other site 932677002282 ATP binding site [chemical binding]; other site 932677002283 Q-loop/lid; other site 932677002284 ABC transporter signature motif; other site 932677002285 Walker B; other site 932677002286 D-loop; other site 932677002287 H-loop/switch region; other site 932677002288 putative lipoprotein; Provisional; Region: PRK10533 932677002289 hypothetical protein; Provisional; Region: PRK02877 932677002290 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 932677002291 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 932677002292 amidase catalytic site [active] 932677002293 Zn binding residues [ion binding]; other site 932677002294 substrate binding site [chemical binding]; other site 932677002295 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 932677002296 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 932677002297 tetramer interface [polypeptide binding]; other site 932677002298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677002299 catalytic residue [active] 932677002300 pyruvate dehydrogenase; Provisional; Region: PRK09124 932677002301 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 932677002302 PYR/PP interface [polypeptide binding]; other site 932677002303 dimer interface [polypeptide binding]; other site 932677002304 tetramer interface [polypeptide binding]; other site 932677002305 TPP binding site [chemical binding]; other site 932677002306 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 932677002307 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 932677002308 TPP-binding site [chemical binding]; other site 932677002309 potential protein location (hypothetical protein hypothetical protein) that overlaps protein (pyruvate dehydrogenase [cytochrome] PoxB) 932677002310 Predicted membrane protein [Function unknown]; Region: COG2431 932677002311 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 932677002312 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 932677002313 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 932677002314 putative active site [active] 932677002315 putative metal-binding site [ion binding]; other site 932677002316 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 932677002317 DNA-binding site [nucleotide binding]; DNA binding site 932677002318 RNA-binding motif; other site 932677002319 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 932677002320 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 932677002321 Clp amino terminal domain; Region: Clp_N; pfam02861 932677002322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677002323 Walker A motif; other site 932677002324 ATP binding site [chemical binding]; other site 932677002325 Walker B motif; other site 932677002326 arginine finger; other site 932677002327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677002328 Walker A motif; other site 932677002329 ATP binding site [chemical binding]; other site 932677002330 Walker B motif; other site 932677002331 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 932677002332 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 932677002333 rRNA binding site [nucleotide binding]; other site 932677002334 predicted 30S ribosome binding site; other site 932677002335 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 932677002336 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 932677002337 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677002338 Walker A/P-loop; other site 932677002339 ATP binding site [chemical binding]; other site 932677002340 Q-loop/lid; other site 932677002341 ABC transporter signature motif; other site 932677002342 Walker B; other site 932677002343 D-loop; other site 932677002344 H-loop/switch region; other site 932677002345 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 932677002346 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932677002347 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 932677002348 Walker A/P-loop; other site 932677002349 ATP binding site [chemical binding]; other site 932677002350 Q-loop/lid; other site 932677002351 ABC transporter signature motif; other site 932677002352 Walker B; other site 932677002353 D-loop; other site 932677002354 H-loop/switch region; other site 932677002355 thioredoxin reductase; Provisional; Region: PRK10262 932677002356 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932677002357 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932677002358 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 932677002359 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932677002360 putative DNA binding site [nucleotide binding]; other site 932677002361 putative Zn2+ binding site [ion binding]; other site 932677002362 AsnC family; Region: AsnC_trans_reg; pfam01037 932677002363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677002364 DNA translocase FtsK; Provisional; Region: PRK10263 932677002365 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 932677002366 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 932677002367 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 932677002368 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 932677002369 recombination factor protein RarA; Reviewed; Region: PRK13342 932677002370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677002371 Walker A motif; other site 932677002372 ATP binding site [chemical binding]; other site 932677002373 Walker B motif; other site 932677002374 arginine finger; other site 932677002375 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 932677002376 seryl-tRNA synthetase; Provisional; Region: PRK05431 932677002377 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 932677002378 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 932677002379 dimer interface [polypeptide binding]; other site 932677002380 active site 932677002381 motif 1; other site 932677002382 motif 2; other site 932677002383 motif 3; other site 932677002384 putative MFS family transporter protein; Provisional; Region: PRK03633 932677002385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677002386 putative substrate translocation pore; other site 932677002387 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 932677002388 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 932677002389 FeS/SAM binding site; other site 932677002390 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 932677002391 Pyruvate formate lyase 1; Region: PFL1; cd01678 932677002392 coenzyme A binding site [chemical binding]; other site 932677002393 active site 932677002394 catalytic residues [active] 932677002395 glycine loop; other site 932677002396 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 932677002397 uncharacterized domain; Region: TIGR00702 932677002398 YcaO-like family; Region: YcaO; pfam02624 932677002399 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 932677002400 homodimer interface [polypeptide binding]; other site 932677002401 substrate-cofactor binding pocket; other site 932677002402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677002403 catalytic residue [active] 932677002404 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 932677002405 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 932677002406 hinge; other site 932677002407 active site 932677002408 cytidylate kinase; Provisional; Region: cmk; PRK00023 932677002409 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 932677002410 CMP-binding site; other site 932677002411 The sites determining sugar specificity; other site 932677002412 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 932677002413 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 932677002414 RNA binding site [nucleotide binding]; other site 932677002415 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 932677002416 RNA binding site [nucleotide binding]; other site 932677002417 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 932677002418 RNA binding site [nucleotide binding]; other site 932677002419 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 932677002420 RNA binding site [nucleotide binding]; other site 932677002421 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 932677002422 RNA binding site [nucleotide binding]; other site 932677002423 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 932677002424 IHF dimer interface [polypeptide binding]; other site 932677002425 IHF - DNA interface [nucleotide binding]; other site 932677002426 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 932677002427 ComEC family competence protein; Provisional; Region: PRK11539 932677002428 Competence protein; Region: Competence; pfam03772 932677002429 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 932677002430 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 932677002431 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932677002432 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 932677002433 Walker A/P-loop; other site 932677002434 ATP binding site [chemical binding]; other site 932677002435 Q-loop/lid; other site 932677002436 ABC transporter signature motif; other site 932677002437 Walker B; other site 932677002438 D-loop; other site 932677002439 H-loop/switch region; other site 932677002440 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 932677002441 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 932677002442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 932677002443 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 932677002444 Trm112p-like protein; Region: Trm112p; cl01066 932677002445 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 932677002446 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 932677002447 Ligand binding site; other site 932677002448 oligomer interface; other site 932677002449 Uncharacterized conserved protein [Function unknown]; Region: COG1434 932677002450 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 932677002451 putative active site [active] 932677002452 Methyltransferase domain; Region: Methyltransf_23; pfam13489 932677002453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677002454 S-adenosylmethionine binding site [chemical binding]; other site 932677002455 condesin subunit F; Provisional; Region: PRK05260 932677002456 condesin subunit E; Provisional; Region: PRK05256 932677002457 cell division protein MukB; Provisional; Region: mukB; PRK04863 932677002458 P-loop containing region of AAA domain; Region: AAA_29; cl17516 932677002459 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 932677002460 murein L,D-transpeptidase; Provisional; Region: PRK10594 932677002461 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 932677002462 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 932677002463 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 932677002464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 932677002465 Peptidase M15; Region: Peptidase_M15_3; cl01194 932677002466 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 932677002467 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 932677002468 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932677002469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677002470 homodimer interface [polypeptide binding]; other site 932677002471 catalytic residue [active] 932677002472 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 932677002473 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 932677002474 trimer interface [polypeptide binding]; other site 932677002475 eyelet of channel; other site 932677002476 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 932677002477 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 932677002478 putative dimer interface [polypeptide binding]; other site 932677002479 putative anticodon binding site; other site 932677002480 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 932677002481 homodimer interface [polypeptide binding]; other site 932677002482 motif 1; other site 932677002483 motif 2; other site 932677002484 active site 932677002485 motif 3; other site 932677002486 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 932677002487 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 932677002488 active site 932677002489 aminopeptidase N; Provisional; Region: pepN; PRK14015 932677002490 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 932677002491 active site 932677002492 Zn binding site [ion binding]; other site 932677002493 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 932677002494 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 932677002495 Walker A/P-loop; other site 932677002496 ATP binding site [chemical binding]; other site 932677002497 Q-loop/lid; other site 932677002498 ABC transporter signature motif; other site 932677002499 Walker B; other site 932677002500 D-loop; other site 932677002501 H-loop/switch region; other site 932677002502 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 932677002503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677002504 dimer interface [polypeptide binding]; other site 932677002505 conserved gate region; other site 932677002506 putative PBP binding loops; other site 932677002507 ABC-ATPase subunit interface; other site 932677002508 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 932677002509 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 932677002510 active site 932677002511 dimer interface [polypeptide binding]; other site 932677002512 non-prolyl cis peptide bond; other site 932677002513 insertion regions; other site 932677002514 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 932677002515 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677002516 substrate binding pocket [chemical binding]; other site 932677002517 membrane-bound complex binding site; other site 932677002518 hinge residues; other site 932677002519 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 932677002520 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 932677002521 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 932677002522 active site 932677002523 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 932677002524 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 932677002525 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 932677002526 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 932677002527 quinone interaction residues [chemical binding]; other site 932677002528 active site 932677002529 catalytic residues [active] 932677002530 FMN binding site [chemical binding]; other site 932677002531 substrate binding site [chemical binding]; other site 932677002532 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 932677002533 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 932677002534 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 932677002535 MOSC domain; Region: MOSC; pfam03473 932677002536 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 932677002537 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 932677002538 catalytic loop [active] 932677002539 iron binding site [ion binding]; other site 932677002540 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 932677002541 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 932677002542 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 932677002543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677002544 S-adenosylmethionine binding site [chemical binding]; other site 932677002545 ABC transporter ATPase component; Reviewed; Region: PRK11147 932677002546 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932677002547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677002548 Walker A/P-loop; other site 932677002549 ATP binding site [chemical binding]; other site 932677002550 Q-loop/lid; other site 932677002551 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932677002552 ABC transporter signature motif; other site 932677002553 Walker B; other site 932677002554 D-loop; other site 932677002555 ABC transporter; Region: ABC_tran_2; pfam12848 932677002556 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932677002557 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 932677002558 Paraquat-inducible protein A; Region: PqiA; pfam04403 932677002559 Paraquat-inducible protein A; Region: PqiA; pfam04403 932677002560 paraquat-inducible protein B; Provisional; Region: PRK10807 932677002561 mce related protein; Region: MCE; pfam02470 932677002562 mce related protein; Region: MCE; pfam02470 932677002563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 932677002564 Protein of unknown function (DUF330); Region: DUF330; pfam03886 932677002565 Ribosome modulation factor; Region: RMF; pfam04957 932677002566 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 932677002567 active site 1 [active] 932677002568 dimer interface [polypeptide binding]; other site 932677002569 active site 2 [active] 932677002570 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 932677002571 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 932677002572 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 932677002573 outer membrane protein A; Reviewed; Region: PRK10808 932677002574 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 932677002575 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 932677002576 ligand binding site [chemical binding]; other site 932677002577 SOS cell division inhibitor; Provisional; Region: PRK10595 932677002578 TfoX N-terminal domain; Region: TfoX_N; pfam04993 932677002579 TfoX C-terminal domain; Region: TfoX_C; pfam04994 932677002580 TIGR01666 family membrane protein; Region: YCCS 932677002581 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 932677002582 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 932677002583 Predicted membrane protein [Function unknown]; Region: COG3304 932677002584 Domain of unknown function (DUF307); Region: DUF307; pfam03733 932677002585 Domain of unknown function (DUF307); Region: DUF307; pfam03733 932677002586 DNA helicase IV; Provisional; Region: helD; PRK11054 932677002587 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 932677002588 Part of AAA domain; Region: AAA_19; pfam13245 932677002589 Family description; Region: UvrD_C_2; pfam13538 932677002590 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 932677002591 active site 932677002592 dimer interfaces [polypeptide binding]; other site 932677002593 catalytic residues [active] 932677002594 hypothetical protein; Provisional; Region: PRK03641 932677002595 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 932677002596 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 932677002597 heat shock protein HspQ; Provisional; Region: PRK14129 932677002598 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 932677002599 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 932677002600 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 932677002601 putative RNA binding site [nucleotide binding]; other site 932677002602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677002603 S-adenosylmethionine binding site [chemical binding]; other site 932677002604 acylphosphatase; Provisional; Region: PRK14426 932677002605 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 932677002606 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 932677002607 YccA-like proteins; Region: YccA_like; cd10433 932677002608 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 932677002609 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 932677002610 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 932677002611 catalytic core [active] 932677002612 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 932677002613 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 932677002614 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 932677002615 NAD(P) binding site [chemical binding]; other site 932677002616 catalytic residues [active] 932677002617 hypothetical protein; Provisional; Region: PRK10174 932677002618 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 932677002619 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 932677002620 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 932677002621 EamA-like transporter family; Region: EamA; pfam00892 932677002622 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 932677002623 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932677002624 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 932677002625 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 932677002626 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 932677002627 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 932677002628 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 932677002629 Autoinducer binding domain; Region: Autoind_bind; pfam03472 932677002630 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 932677002631 DNA binding residues [nucleotide binding] 932677002632 dimerization interface [polypeptide binding]; other site 932677002633 Autoinducer synthetase; Region: Autoind_synth; cl17404 932677002634 hypothetical protein; Provisional; Region: PRK10613 932677002635 response regulator; Provisional; Region: PRK09483 932677002636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677002637 active site 932677002638 phosphorylation site [posttranslational modification] 932677002639 intermolecular recognition site; other site 932677002640 dimerization interface [polypeptide binding]; other site 932677002641 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 932677002642 DNA binding residues [nucleotide binding] 932677002643 dimerization interface [polypeptide binding]; other site 932677002644 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 932677002645 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 932677002646 active site 932677002647 catalytic site [active] 932677002648 putative DNA binding site [nucleotide binding]; other site 932677002649 GIY-YIG motif/motif A; other site 932677002650 metal binding site [ion binding]; metal-binding site 932677002651 UvrB/uvrC motif; Region: UVR; pfam02151 932677002652 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 932677002653 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 932677002654 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 932677002655 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 932677002656 active site 932677002657 DNA binding site [nucleotide binding] 932677002658 Int/Topo IB signature motif; other site 932677002659 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932677002660 non-specific DNA binding site [nucleotide binding]; other site 932677002661 Predicted transcriptional regulator [Transcription]; Region: COG2932 932677002662 salt bridge; other site 932677002663 sequence-specific DNA binding site [nucleotide binding]; other site 932677002664 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 932677002665 Catalytic site [active] 932677002666 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752 932677002667 ParB-like nuclease domain; Region: ParB; smart00470 932677002668 KorB domain; Region: KorB; pfam08535 932677002669 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 932677002670 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 932677002671 Protein of unknown function (DUF968); Region: DUF968; pfam06147 932677002672 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932677002673 non-specific DNA binding site [nucleotide binding]; other site 932677002674 salt bridge; other site 932677002675 sequence-specific DNA binding site [nucleotide binding]; other site 932677002676 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 932677002677 SecA binding site; other site 932677002678 Preprotein binding site; other site 932677002679 Phage terminase, small subunit; Region: Terminase_4; cl01525 932677002680 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 932677002681 Phage portal protein; Region: Phage_portal; pfam04860 932677002682 Phage-related protein [Function unknown]; Region: COG4695 932677002683 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 932677002684 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 932677002685 oligomer interface [polypeptide binding]; other site 932677002686 active site residues [active] 932677002687 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 932677002688 Phage capsid family; Region: Phage_capsid; pfam05065 932677002689 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 932677002690 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 932677002691 Phage minor tail protein L; Region: Phage_tail_L; cl01908 932677002692 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 932677002693 MPN+ (JAMM) motif; other site 932677002694 Zinc-binding site [ion binding]; other site 932677002695 NlpC/P60 family; Region: NLPC_P60; pfam00877 932677002696 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 932677002697 Phage-related protein, tail component [Function unknown]; Region: COG4723 932677002698 Phage-related protein, tail component [Function unknown]; Region: COG4733 932677002699 Putative phage tail protein; Region: Phage-tail_3; pfam13550 932677002700 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 932677002701 Interdomain contacts; other site 932677002702 Cytokine receptor motif; other site 932677002703 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 932677002704 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 932677002705 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 932677002706 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 932677002707 active site 932677002708 DNA binding site [nucleotide binding] 932677002709 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 932677002710 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 932677002711 YrhK-like protein; Region: YrhK; pfam14145 932677002712 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 932677002713 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 932677002714 Sulfate transporter family; Region: Sulfate_transp; pfam00916 932677002715 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 932677002716 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 932677002717 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 932677002718 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 932677002719 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677002720 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 932677002721 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 932677002722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677002723 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 932677002724 putative substrate translocation pore; other site 932677002725 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 932677002726 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 932677002727 HlyD family secretion protein; Region: HlyD_3; pfam13437 932677002728 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 932677002729 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 932677002730 PLD-like domain; Region: PLDc_2; pfam13091 932677002731 putative active site [active] 932677002732 catalytic site [active] 932677002733 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 932677002734 PLD-like domain; Region: PLDc_2; pfam13091 932677002735 putative active site [active] 932677002736 catalytic site [active] 932677002737 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 932677002738 Acyltransferase family; Region: Acyl_transf_3; pfam01757 932677002739 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 932677002740 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 932677002741 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 932677002742 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 932677002743 Ligand binding site; other site 932677002744 DXD motif; other site 932677002745 lipoprotein; Provisional; Region: PRK10175 932677002746 secY/secA suppressor protein; Provisional; Region: PRK11467 932677002747 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 932677002748 TetR family transcriptional regulator; Provisional; Region: PRK14996 932677002749 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932677002750 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 932677002751 putative acyl-acceptor binding pocket; other site 932677002752 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 932677002753 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 932677002754 active site residue [active] 932677002755 hypothetical protein; Provisional; Region: PRK03757 932677002756 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 932677002757 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 932677002758 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932677002759 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 932677002760 DNA damage-inducible protein I; Provisional; Region: PRK10597 932677002761 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 932677002762 active site 932677002763 substrate binding pocket [chemical binding]; other site 932677002764 dimer interface [polypeptide binding]; other site 932677002765 lipoprotein; Provisional; Region: PRK10598 932677002766 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 932677002767 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 932677002768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 932677002769 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 932677002770 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932677002771 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 932677002772 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 932677002773 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 932677002774 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 932677002775 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 932677002776 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677002777 dimer interface [polypeptide binding]; other site 932677002778 putative CheW interface [polypeptide binding]; other site 932677002779 FlgN protein; Region: FlgN; cl09176 932677002780 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 932677002781 SAF-like; Region: SAF_2; pfam13144 932677002782 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 932677002783 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 932677002784 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 932677002785 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 932677002786 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 932677002787 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 932677002788 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 932677002789 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 932677002790 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 932677002791 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 932677002792 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 932677002793 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 932677002794 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 932677002795 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 932677002796 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 932677002797 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 932677002798 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 932677002799 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 932677002800 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 932677002801 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 932677002802 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 932677002803 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 932677002804 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 932677002805 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 932677002806 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 932677002807 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 932677002808 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 932677002809 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 932677002810 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 932677002811 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 932677002812 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 932677002813 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 932677002814 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 932677002815 homodimer interface [polypeptide binding]; other site 932677002816 oligonucleotide binding site [chemical binding]; other site 932677002817 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 932677002818 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 932677002819 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932677002820 RNA binding surface [nucleotide binding]; other site 932677002821 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 932677002822 active site 932677002823 Maf-like protein; Region: Maf; pfam02545 932677002824 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 932677002825 active site 932677002826 dimer interface [polypeptide binding]; other site 932677002827 hypothetical protein; Provisional; Region: PRK11193 932677002828 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 932677002829 putative phosphate acyltransferase; Provisional; Region: PRK05331 932677002830 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 932677002831 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 932677002832 dimer interface [polypeptide binding]; other site 932677002833 active site 932677002834 CoA binding pocket [chemical binding]; other site 932677002835 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 932677002836 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 932677002837 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 932677002838 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 932677002839 NAD(P) binding site [chemical binding]; other site 932677002840 homotetramer interface [polypeptide binding]; other site 932677002841 homodimer interface [polypeptide binding]; other site 932677002842 active site 932677002843 acyl carrier protein; Provisional; Region: acpP; PRK00982 932677002844 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 932677002845 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 932677002846 dimer interface [polypeptide binding]; other site 932677002847 active site 932677002848 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 932677002849 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 932677002850 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677002851 catalytic residue [active] 932677002852 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 932677002853 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 932677002854 dimerization interface [polypeptide binding]; other site 932677002855 thymidylate kinase; Validated; Region: tmk; PRK00698 932677002856 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 932677002857 TMP-binding site; other site 932677002858 ATP-binding site [chemical binding]; other site 932677002859 DNA polymerase III subunit delta'; Validated; Region: PRK07993 932677002860 DNA polymerase III subunit delta'; Validated; Region: PRK08485 932677002861 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 932677002862 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 932677002863 active site 932677002864 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 932677002865 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 932677002866 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 932677002867 active site turn [active] 932677002868 phosphorylation site [posttranslational modification] 932677002869 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 932677002870 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 932677002871 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677002872 dimer interface [polypeptide binding]; other site 932677002873 putative CheW interface [polypeptide binding]; other site 932677002874 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 932677002875 nucleotide binding site/active site [active] 932677002876 HIT family signature motif; other site 932677002877 catalytic residue [active] 932677002878 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 932677002879 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 932677002880 putative dimer interface [polypeptide binding]; other site 932677002881 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 932677002882 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 932677002883 substrate binding site [chemical binding]; other site 932677002884 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 932677002885 beta-hexosaminidase; Provisional; Region: PRK05337 932677002886 hypothetical protein; Provisional; Region: PRK04940 932677002887 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 932677002888 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932677002889 hypothetical protein; Provisional; Region: PRK11280 932677002890 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 932677002891 MarR family; Region: MarR_2; pfam12802 932677002892 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 932677002893 Uncharacterized conserved protein [Function unknown]; Region: COG2128 932677002894 transcription-repair coupling factor; Provisional; Region: PRK10689 932677002895 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 932677002896 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932677002897 ATP binding site [chemical binding]; other site 932677002898 putative Mg++ binding site [ion binding]; other site 932677002899 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932677002900 nucleotide binding region [chemical binding]; other site 932677002901 ATP-binding site [chemical binding]; other site 932677002902 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 932677002903 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 932677002904 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 932677002905 FtsX-like permease family; Region: FtsX; pfam02687 932677002906 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 932677002907 Walker A/P-loop; other site 932677002908 ATP binding site [chemical binding]; other site 932677002909 ABC transporter; Region: ABC_tran; pfam00005 932677002910 Q-loop/lid; other site 932677002911 ABC transporter signature motif; other site 932677002912 Walker B; other site 932677002913 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 932677002914 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 932677002915 FtsX-like permease family; Region: FtsX; pfam02687 932677002916 NAD-dependent deacetylase; Provisional; Region: PRK00481 932677002917 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 932677002918 NAD+ binding site [chemical binding]; other site 932677002919 substrate binding site [chemical binding]; other site 932677002920 Zn binding site [ion binding]; other site 932677002921 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 932677002922 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 932677002923 metal binding site [ion binding]; metal-binding site 932677002924 dimer interface [polypeptide binding]; other site 932677002925 Uncharacterized conserved protein [Function unknown]; Region: COG2850 932677002926 Cupin-like domain; Region: Cupin_8; pfam13621 932677002927 sensor protein PhoQ; Provisional; Region: PRK10815 932677002928 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 932677002929 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932677002930 dimer interface [polypeptide binding]; other site 932677002931 phosphorylation site [posttranslational modification] 932677002932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677002933 ATP binding site [chemical binding]; other site 932677002934 Mg2+ binding site [ion binding]; other site 932677002935 G-X-G motif; other site 932677002936 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 932677002937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677002938 active site 932677002939 phosphorylation site [posttranslational modification] 932677002940 intermolecular recognition site; other site 932677002941 dimerization interface [polypeptide binding]; other site 932677002942 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932677002943 DNA binding site [nucleotide binding] 932677002944 adenylosuccinate lyase; Provisional; Region: PRK09285 932677002945 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 932677002946 tetramer interface [polypeptide binding]; other site 932677002947 active site 932677002948 putative lysogenization regulator; Reviewed; Region: PRK00218 932677002949 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 932677002950 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 932677002951 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 932677002952 nudix motif; other site 932677002953 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 932677002954 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 932677002955 active site 932677002956 isocitrate dehydrogenase; Validated; Region: PRK07362 932677002957 isocitrate dehydrogenase; Reviewed; Region: PRK07006 932677002958 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 932677002959 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 932677002960 putative active site [active] 932677002961 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 932677002962 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 932677002963 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 932677002964 putative fimbrial usher protein StbD; Provisional; Region: PRK15247 932677002965 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 932677002966 PapC C-terminal domain; Region: PapC_C; pfam13953 932677002967 fimbrial chaperone protein StbB; Provisional; Region: PRK15249 932677002968 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 932677002969 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 932677002970 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 932677002971 hypothetical protein; Provisional; Region: PRK06185 932677002972 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 932677002973 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932677002974 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932677002975 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932677002976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932677002977 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 932677002978 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 932677002979 Protein export membrane protein; Region: SecD_SecF; cl14618 932677002980 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 932677002981 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 932677002982 HlyD family secretion protein; Region: HlyD_3; pfam13437 932677002983 nucleoside transporter; Region: 2A0110; TIGR00889 932677002984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677002985 putative substrate translocation pore; other site 932677002986 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 932677002987 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 932677002988 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 932677002989 substrate binding site [chemical binding]; other site 932677002990 ATP binding site [chemical binding]; other site 932677002991 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 932677002992 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932677002993 DNA-binding site [nucleotide binding]; DNA binding site 932677002994 UTRA domain; Region: UTRA; pfam07702 932677002995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677002996 metabolite-proton symporter; Region: 2A0106; TIGR00883 932677002997 putative substrate translocation pore; other site 932677002998 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677002999 Coenzyme A binding pocket [chemical binding]; other site 932677003000 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 932677003001 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 932677003002 dimer interface [polypeptide binding]; other site 932677003003 catalytic triad [active] 932677003004 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 932677003005 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 932677003006 N-acetyl-D-glucosamine binding site [chemical binding]; other site 932677003007 catalytic residue [active] 932677003008 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 932677003009 MarR family; Region: MarR_2; pfam12802 932677003010 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 932677003011 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 932677003012 TPP-binding site [chemical binding]; other site 932677003013 dimer interface [polypeptide binding]; other site 932677003014 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 932677003015 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 932677003016 PYR/PP interface [polypeptide binding]; other site 932677003017 dimer interface [polypeptide binding]; other site 932677003018 TPP binding site [chemical binding]; other site 932677003019 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 932677003020 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 932677003021 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 932677003022 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 932677003023 N- and C-terminal domain interface [polypeptide binding]; other site 932677003024 active site 932677003025 MgATP binding site [chemical binding]; other site 932677003026 catalytic site [active] 932677003027 metal binding site [ion binding]; metal-binding site 932677003028 putative homotetramer interface [polypeptide binding]; other site 932677003029 putative homodimer interface [polypeptide binding]; other site 932677003030 glycerol binding site [chemical binding]; other site 932677003031 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 932677003032 Mechanosensitive ion channel; Region: MS_channel; pfam00924 932677003033 Flagellar regulator YcgR; Region: YcgR; pfam07317 932677003034 PilZ domain; Region: PilZ; pfam07238 932677003035 hypothetical protein; Provisional; Region: PRK10457 932677003036 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 932677003037 Trehalase; Region: Trehalase; cl17346 932677003038 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 932677003039 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 932677003040 putative ligand binding site [chemical binding]; other site 932677003041 NAD binding site [chemical binding]; other site 932677003042 dimerization interface [polypeptide binding]; other site 932677003043 catalytic site [active] 932677003044 putative hydrolase; Validated; Region: PRK09248 932677003045 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 932677003046 active site 932677003047 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 932677003048 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 932677003049 CoA-transferase family III; Region: CoA_transf_3; pfam02515 932677003050 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 932677003051 EamA-like transporter family; Region: EamA; pfam00892 932677003052 EamA-like transporter family; Region: EamA; pfam00892 932677003053 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 932677003054 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 932677003055 catalytic triad [active] 932677003056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677003057 S-adenosylmethionine binding site [chemical binding]; other site 932677003058 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 932677003059 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 932677003060 NAD(P) binding site [chemical binding]; other site 932677003061 catalytic residues [active] 932677003062 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 932677003063 Cupin; Region: Cupin_1; smart00835 932677003064 Cupin; Region: Cupin_1; smart00835 932677003065 The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain; Region: ASCH; smart01022 932677003066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 932677003067 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 932677003068 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 932677003069 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 932677003070 beta-galactosidase; Region: BGL; TIGR03356 932677003071 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 932677003072 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 932677003073 active site turn [active] 932677003074 phosphorylation site [posttranslational modification] 932677003075 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 932677003076 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 932677003077 HPr interaction site; other site 932677003078 glycerol kinase (GK) interaction site [polypeptide binding]; other site 932677003079 active site 932677003080 phosphorylation site [posttranslational modification] 932677003081 transcriptional antiterminator BglG; Provisional; Region: PRK09772 932677003082 CAT RNA binding domain; Region: CAT_RBD; smart01061 932677003083 PRD domain; Region: PRD; pfam00874 932677003084 PRD domain; Region: PRD; pfam00874 932677003085 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 932677003086 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677003087 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 932677003088 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 932677003089 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 932677003090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 932677003091 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 932677003092 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 932677003093 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 932677003094 FMN binding site [chemical binding]; other site 932677003095 active site 932677003096 substrate binding site [chemical binding]; other site 932677003097 catalytic residue [active] 932677003098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677003099 Coenzyme A binding pocket [chemical binding]; other site 932677003100 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 932677003101 active site 932677003102 DNA binding site [nucleotide binding] 932677003103 Int/Topo IB signature motif; other site 932677003104 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 932677003105 HAMP domain; Region: HAMP; pfam00672 932677003106 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677003107 dimer interface [polypeptide binding]; other site 932677003108 putative CheW interface [polypeptide binding]; other site 932677003109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677003110 Coenzyme A binding pocket [chemical binding]; other site 932677003111 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 932677003112 benzoate transport; Region: 2A0115; TIGR00895 932677003113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677003114 putative substrate translocation pore; other site 932677003115 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 932677003116 Amidohydrolase; Region: Amidohydro_2; pfam04909 932677003117 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 932677003118 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 932677003119 conserved cys residue [active] 932677003120 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 932677003121 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 932677003122 inhibitor site; inhibition site 932677003123 active site 932677003124 dimer interface [polypeptide binding]; other site 932677003125 catalytic residue [active] 932677003126 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 932677003127 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 932677003128 N-terminal plug; other site 932677003129 ligand-binding site [chemical binding]; other site 932677003130 Cupin domain; Region: Cupin_2; pfam07883 932677003131 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 932677003132 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677003133 Dehydratase family; Region: ILVD_EDD; cl00340 932677003134 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 932677003135 Amidase; Region: Amidase; pfam01425 932677003136 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932677003137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932677003138 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 932677003139 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932677003140 non-specific DNA binding site [nucleotide binding]; other site 932677003141 salt bridge; other site 932677003142 sequence-specific DNA binding site [nucleotide binding]; other site 932677003143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 932677003144 Transposase; Region: DEDD_Tnp_IS110; pfam01548 932677003145 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 932677003146 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 932677003147 structural tetrad; other site 932677003148 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 932677003149 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 932677003150 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 932677003151 gating phenylalanine in ion channel; other site 932677003152 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 932677003153 ligand binding site [chemical binding]; other site 932677003154 active site 932677003155 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 932677003156 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 932677003157 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 932677003158 phosphate binding site [ion binding]; other site 932677003159 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 932677003160 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 932677003161 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 932677003162 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 932677003163 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677003164 Coenzyme A binding pocket [chemical binding]; other site 932677003165 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 932677003166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932677003167 non-specific DNA binding site [nucleotide binding]; other site 932677003168 salt bridge; other site 932677003169 sequence-specific DNA binding site [nucleotide binding]; other site 932677003170 Cupin domain; Region: Cupin_2; cl17218 932677003171 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 932677003172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677003173 Coenzyme A binding pocket [chemical binding]; other site 932677003174 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 932677003175 mannosyl binding site [chemical binding]; other site 932677003176 Fimbrial protein; Region: Fimbrial; pfam00419 932677003177 Fimbrial protein; Region: Fimbrial; cl01416 932677003178 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 932677003179 outer membrane usher protein; Provisional; Region: PRK15193 932677003180 PapC N-terminal domain; Region: PapC_N; pfam13954 932677003181 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 932677003182 PapC C-terminal domain; Region: PapC_C; pfam13953 932677003183 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 932677003184 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 932677003185 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 932677003186 Fimbrial protein; Region: Fimbrial; cl01416 932677003187 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932677003188 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 932677003189 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 932677003190 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 932677003191 hypothetical protein; Provisional; Region: PRK09945 932677003192 hypothetical protein; Provisional; Region: PRK09945 932677003193 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 932677003194 Autotransporter beta-domain; Region: Autotransporter; pfam03797 932677003195 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677003196 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677003197 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 932677003198 dimerization interface [polypeptide binding]; other site 932677003199 EamA-like transporter family; Region: EamA; cl17759 932677003200 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 932677003201 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932677003202 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 932677003203 active site 932677003204 metal binding site [ion binding]; metal-binding site 932677003205 Uncharacterized conserved protein [Function unknown]; Region: COG2353 932677003206 RNA polymerase sigma factor; Provisional; Region: PRK12511 932677003207 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 932677003208 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 932677003209 DNA binding residues [nucleotide binding] 932677003210 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932677003211 binding surface 932677003212 TPR motif; other site 932677003213 Tetratricopeptide repeat; Region: TPR_16; pfam13432 932677003214 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 932677003215 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 932677003216 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 932677003217 dimerization interface [polypeptide binding]; other site 932677003218 NAD binding site [chemical binding]; other site 932677003219 ligand binding site [chemical binding]; other site 932677003220 catalytic site [active] 932677003221 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 932677003222 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 932677003223 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 932677003224 catalytic motif [active] 932677003225 Zn binding site [ion binding]; other site 932677003226 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 932677003227 active site 932677003228 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 932677003229 methionine synthase; Provisional; Region: PRK01207 932677003230 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 932677003231 substrate binding site [chemical binding]; other site 932677003232 THF binding site; other site 932677003233 zinc-binding site [ion binding]; other site 932677003234 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 932677003235 catalytic residues [active] 932677003236 dimer interface [polypeptide binding]; other site 932677003237 MarR family; Region: MarR_2; cl17246 932677003238 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 932677003239 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 932677003240 Flavoprotein; Region: Flavoprotein; pfam02441 932677003241 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 932677003242 major facilitator superfamily transporter; Provisional; Region: PRK05122 932677003243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677003244 putative substrate translocation pore; other site 932677003245 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 932677003246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677003247 putative substrate translocation pore; other site 932677003248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677003249 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 932677003250 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 932677003251 Metal-binding active site; metal-binding site 932677003252 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 932677003253 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932677003254 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 932677003255 FIST N domain; Region: FIST; smart00897 932677003256 FIST C domain; Region: FIST_C; pfam10442 932677003257 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677003258 dimer interface [polypeptide binding]; other site 932677003259 putative CheW interface [polypeptide binding]; other site 932677003260 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 932677003261 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 932677003262 active site 932677003263 homotetramer interface [polypeptide binding]; other site 932677003264 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677003265 Coenzyme A binding pocket [chemical binding]; other site 932677003266 FOG: CBS domain [General function prediction only]; Region: COG0517 932677003267 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 932677003268 Divalent cation transporter; Region: MgtE; pfam01769 932677003269 AAA domain; Region: AAA_13; pfam13166 932677003270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 932677003271 ABC transporter signature motif; other site 932677003272 Walker B; other site 932677003273 D-loop; other site 932677003274 H-loop/switch region; other site 932677003275 putative transposase OrfB; Reviewed; Region: PHA02517 932677003276 HTH-like domain; Region: HTH_21; pfam13276 932677003277 Integrase core domain; Region: rve; pfam00665 932677003278 Integrase core domain; Region: rve_3; pfam13683 932677003279 GTP-binding protein YchF; Reviewed; Region: PRK09601 932677003280 YchF GTPase; Region: YchF; cd01900 932677003281 G1 box; other site 932677003282 GTP/Mg2+ binding site [chemical binding]; other site 932677003283 Switch I region; other site 932677003284 G2 box; other site 932677003285 Switch II region; other site 932677003286 G3 box; other site 932677003287 G4 box; other site 932677003288 G5 box; other site 932677003289 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 932677003290 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 932677003291 putative active site [active] 932677003292 catalytic residue [active] 932677003293 hypothetical protein; Provisional; Region: PRK10692 932677003294 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932677003295 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932677003296 metal binding site [ion binding]; metal-binding site 932677003297 active site 932677003298 I-site; other site 932677003299 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 932677003300 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 932677003301 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932677003302 active site 932677003303 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 932677003304 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 932677003305 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 932677003306 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 932677003307 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 932677003308 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 932677003309 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 932677003310 tRNA; other site 932677003311 putative tRNA binding site [nucleotide binding]; other site 932677003312 putative NADP binding site [chemical binding]; other site 932677003313 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 932677003314 peptide chain release factor 1; Validated; Region: prfA; PRK00591 932677003315 This domain is found in peptide chain release factors; Region: PCRF; smart00937 932677003316 RF-1 domain; Region: RF-1; pfam00472 932677003317 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 932677003318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677003319 S-adenosylmethionine binding site [chemical binding]; other site 932677003320 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 932677003321 hypothetical protein; Provisional; Region: PRK10941 932677003322 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 932677003323 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 932677003324 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 932677003325 potential protein location (hypothetical protein) that overlaps protein (2-dehydro-3-deoxyphosphooctonate aldolase KdsA) 932677003326 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 932677003327 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 932677003328 cation transport regulator; Reviewed; Region: chaB; PRK09582 932677003329 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 932677003330 dimerization interface [polypeptide binding]; other site 932677003331 putative active site pocket [active] 932677003332 putative catalytic residue [active] 932677003333 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 932677003334 Catalytic domain of Protein Kinases; Region: PKc; cd00180 932677003335 active site 932677003336 ATP binding site [chemical binding]; other site 932677003337 substrate binding site [chemical binding]; other site 932677003338 activation loop (A-loop); other site 932677003339 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 932677003340 active site 932677003341 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 932677003342 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 932677003343 phosphopeptide binding site; other site 932677003344 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 932677003345 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 932677003346 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 932677003347 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 932677003348 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 932677003349 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 932677003350 ligand binding site [chemical binding]; other site 932677003351 Nitrate and nitrite sensing; Region: NIT; pfam08376 932677003352 ANTAR domain; Region: ANTAR; pfam03861 932677003353 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 932677003354 NMT1-like family; Region: NMT1_2; pfam13379 932677003355 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 932677003356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677003357 dimer interface [polypeptide binding]; other site 932677003358 conserved gate region; other site 932677003359 putative PBP binding loops; other site 932677003360 ABC-ATPase subunit interface; other site 932677003361 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 932677003362 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 932677003363 Walker A/P-loop; other site 932677003364 ATP binding site [chemical binding]; other site 932677003365 Q-loop/lid; other site 932677003366 ABC transporter signature motif; other site 932677003367 Walker B; other site 932677003368 D-loop; other site 932677003369 H-loop/switch region; other site 932677003370 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 932677003371 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932677003372 nitrite reductase subunit NirD; Provisional; Region: PRK14989 932677003373 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932677003374 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 932677003375 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 932677003376 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 932677003377 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 932677003378 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 932677003379 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 932677003380 [4Fe-4S] binding site [ion binding]; other site 932677003381 molybdopterin cofactor binding site; other site 932677003382 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 932677003383 molybdopterin cofactor binding site; other site 932677003384 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 932677003385 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 932677003386 active site 932677003387 SAM binding site [chemical binding]; other site 932677003388 homodimer interface [polypeptide binding]; other site 932677003389 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 932677003390 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 932677003391 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 932677003392 short chain dehydrogenase; Provisional; Region: PRK06841 932677003393 classical (c) SDRs; Region: SDR_c; cd05233 932677003394 NAD(P) binding site [chemical binding]; other site 932677003395 active site 932677003396 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 932677003397 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 932677003398 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 932677003399 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 932677003400 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 932677003401 Walker A/P-loop; other site 932677003402 ATP binding site [chemical binding]; other site 932677003403 Q-loop/lid; other site 932677003404 ABC transporter signature motif; other site 932677003405 Walker B; other site 932677003406 D-loop; other site 932677003407 H-loop/switch region; other site 932677003408 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 932677003409 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 932677003410 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932677003411 TM-ABC transporter signature motif; other site 932677003412 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 932677003413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932677003414 NAD(P) binding site [chemical binding]; other site 932677003415 active site 932677003416 putative invasin; Provisional; Region: PRK10177 932677003417 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 932677003418 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 932677003419 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 932677003420 eyelet of channel; other site 932677003421 trimer interface [polypeptide binding]; other site 932677003422 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 932677003423 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 932677003424 inhibitor-cofactor binding pocket; inhibition site 932677003425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677003426 catalytic residue [active] 932677003427 arginine succinyltransferase; Provisional; Region: PRK10456 932677003428 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 932677003429 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 932677003430 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 932677003431 NAD(P) binding site [chemical binding]; other site 932677003432 catalytic residues [active] 932677003433 succinylarginine dihydrolase; Provisional; Region: PRK13281 932677003434 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 932677003435 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 932677003436 putative active site [active] 932677003437 Zn binding site [ion binding]; other site 932677003438 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 932677003439 dimer interface [polypeptide binding]; other site 932677003440 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 932677003441 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 932677003442 GIY-YIG motif/motif A; other site 932677003443 active site 932677003444 catalytic site [active] 932677003445 putative DNA binding site [nucleotide binding]; other site 932677003446 metal binding site [ion binding]; metal-binding site 932677003447 aromatic amino acid exporter; Provisional; Region: PRK11689 932677003448 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 932677003449 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677003450 dimer interface [polypeptide binding]; other site 932677003451 putative CheW interface [polypeptide binding]; other site 932677003452 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 932677003453 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 932677003454 homodimer interface [polypeptide binding]; other site 932677003455 NAD binding pocket [chemical binding]; other site 932677003456 ATP binding pocket [chemical binding]; other site 932677003457 Mg binding site [ion binding]; other site 932677003458 active-site loop [active] 932677003459 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 932677003460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677003461 putative substrate translocation pore; other site 932677003462 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 932677003463 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 932677003464 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 932677003465 inner membrane protein; Provisional; Region: PRK11648 932677003466 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 932677003467 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 932677003468 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677003469 motif II; other site 932677003470 YniB-like protein; Region: YniB; pfam14002 932677003471 Fructosamine kinase; Region: Fructosamin_kin; cl17579 932677003472 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 932677003473 Protein of unknown function, DUF481; Region: DUF481; cl01213 932677003474 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 932677003475 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 932677003476 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 932677003477 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 932677003478 active site 932677003479 dimer interface [polypeptide binding]; other site 932677003480 motif 1; other site 932677003481 motif 2; other site 932677003482 motif 3; other site 932677003483 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 932677003484 anticodon binding site; other site 932677003485 translation initiation factor IF-3; Region: infC; TIGR00168 932677003486 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 932677003487 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 932677003488 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 932677003489 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 932677003490 23S rRNA binding site [nucleotide binding]; other site 932677003491 L21 binding site [polypeptide binding]; other site 932677003492 L13 binding site [polypeptide binding]; other site 932677003493 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 932677003494 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 932677003495 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 932677003496 dimer interface [polypeptide binding]; other site 932677003497 motif 1; other site 932677003498 active site 932677003499 motif 2; other site 932677003500 motif 3; other site 932677003501 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 932677003502 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 932677003503 putative tRNA-binding site [nucleotide binding]; other site 932677003504 B3/4 domain; Region: B3_4; pfam03483 932677003505 tRNA synthetase B5 domain; Region: B5; smart00874 932677003506 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 932677003507 dimer interface [polypeptide binding]; other site 932677003508 motif 1; other site 932677003509 motif 3; other site 932677003510 motif 2; other site 932677003511 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 932677003512 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 932677003513 IHF dimer interface [polypeptide binding]; other site 932677003514 IHF - DNA interface [nucleotide binding]; other site 932677003515 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 932677003516 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932677003517 ABC-ATPase subunit interface; other site 932677003518 dimer interface [polypeptide binding]; other site 932677003519 putative PBP binding regions; other site 932677003520 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 932677003521 catalytic residues [active] 932677003522 dimer interface [polypeptide binding]; other site 932677003523 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 932677003524 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 932677003525 Walker A/P-loop; other site 932677003526 ATP binding site [chemical binding]; other site 932677003527 Q-loop/lid; other site 932677003528 ABC transporter signature motif; other site 932677003529 Walker B; other site 932677003530 D-loop; other site 932677003531 H-loop/switch region; other site 932677003532 NlpC/P60 family; Region: NLPC_P60; cl17555 932677003533 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 932677003534 Uncharacterized conserved protein [Function unknown]; Region: COG0397 932677003535 hypothetical protein; Validated; Region: PRK00029 932677003536 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 932677003537 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 932677003538 PEP synthetase regulatory protein; Provisional; Region: PRK05339 932677003539 phosphoenolpyruvate synthase; Validated; Region: PRK06464 932677003540 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 932677003541 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 932677003542 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 932677003543 putative inner membrane protein; Provisional; Region: PRK10983 932677003544 Domain of unknown function DUF20; Region: UPF0118; pfam01594 932677003545 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 932677003546 FAD binding domain; Region: FAD_binding_4; pfam01565 932677003547 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 932677003548 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 932677003549 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 932677003550 putative ABC transporter; Region: ycf24; CHL00085 932677003551 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 932677003552 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 932677003553 Walker A/P-loop; other site 932677003554 ATP binding site [chemical binding]; other site 932677003555 Q-loop/lid; other site 932677003556 ABC transporter signature motif; other site 932677003557 Walker B; other site 932677003558 D-loop; other site 932677003559 H-loop/switch region; other site 932677003560 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 932677003561 FeS assembly protein SufD; Region: sufD; TIGR01981 932677003562 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 932677003563 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 932677003564 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932677003565 catalytic residue [active] 932677003566 cysteine desufuration protein SufE; Provisional; Region: PRK09296 932677003567 L,D-transpeptidase; Provisional; Region: PRK10190 932677003568 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932677003569 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 932677003570 murein lipoprotein; Provisional; Region: PRK15396 932677003571 pyruvate kinase; Provisional; Region: PRK09206 932677003572 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 932677003573 domain interfaces; other site 932677003574 active site 932677003575 multidrug efflux protein; Reviewed; Region: PRK01766 932677003576 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 932677003577 cation binding site [ion binding]; other site 932677003578 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 932677003579 Lumazine binding domain; Region: Lum_binding; pfam00677 932677003580 Lumazine binding domain; Region: Lum_binding; pfam00677 932677003581 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 932677003582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677003583 S-adenosylmethionine binding site [chemical binding]; other site 932677003584 potential protein location (hypothetical protein) that overlaps protein (cyclopropane-fatty-acyl-phospholipid synthase Cfa) 932677003585 putative transporter; Provisional; Region: PRK11043 932677003586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677003587 putative substrate translocation pore; other site 932677003588 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 932677003589 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677003590 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 932677003591 dimerization interface [polypeptide binding]; other site 932677003592 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932677003593 DNA binding site [nucleotide binding] 932677003594 domain linker motif; other site 932677003595 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 932677003596 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 932677003597 NlpC/P60 family; Region: NLPC_P60; pfam00877 932677003598 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 932677003599 putative GSH binding site [chemical binding]; other site 932677003600 catalytic residues [active] 932677003601 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 932677003602 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 932677003603 dimer interface [polypeptide binding]; other site 932677003604 catalytic site [active] 932677003605 putative active site [active] 932677003606 putative substrate binding site [chemical binding]; other site 932677003607 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932677003608 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 932677003609 dimer interface [polypeptide binding]; other site 932677003610 active site 932677003611 metal binding site [ion binding]; metal-binding site 932677003612 glutathione binding site [chemical binding]; other site 932677003613 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 932677003614 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 932677003615 FMN binding site [chemical binding]; other site 932677003616 active site 932677003617 substrate binding site [chemical binding]; other site 932677003618 catalytic residue [active] 932677003619 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932677003620 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932677003621 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932677003622 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932677003623 active site 932677003624 catalytic tetrad [active] 932677003625 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 932677003626 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 932677003627 E-class dimer interface [polypeptide binding]; other site 932677003628 P-class dimer interface [polypeptide binding]; other site 932677003629 active site 932677003630 Cu2+ binding site [ion binding]; other site 932677003631 Zn2+ binding site [ion binding]; other site 932677003632 Fusaric acid resistance protein family; Region: FUSC; pfam04632 932677003633 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 932677003634 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 932677003635 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 932677003636 HlyD family secretion protein; Region: HlyD_3; pfam13437 932677003637 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 932677003638 transcriptional regulator SlyA; Provisional; Region: PRK03573 932677003639 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 932677003640 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 932677003641 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 932677003642 Sensors of blue-light using FAD; Region: BLUF; pfam04940 932677003643 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932677003644 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 932677003645 classical (c) SDRs; Region: SDR_c; cd05233 932677003646 NAD(P) binding site [chemical binding]; other site 932677003647 active site 932677003648 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 932677003649 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 932677003650 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 932677003651 active site 932677003652 catalytic site [active] 932677003653 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 932677003654 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 932677003655 active site 932677003656 catalytic site [active] 932677003657 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 932677003658 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 932677003659 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 932677003660 catalytic site [active] 932677003661 active site 932677003662 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 932677003663 hydroperoxidase II; Provisional; Region: katE; PRK11249 932677003664 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 932677003665 tetramer interface [polypeptide binding]; other site 932677003666 heme binding pocket [chemical binding]; other site 932677003667 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 932677003668 domain interactions; other site 932677003669 UV-endonuclease UvdE; Region: UvdE; cl10036 932677003670 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 932677003671 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 932677003672 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 932677003673 conserved cys residue [active] 932677003674 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 932677003675 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 932677003676 dimerization interface [polypeptide binding]; other site 932677003677 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 932677003678 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 932677003679 Catalytic site [active] 932677003680 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 932677003681 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 932677003682 active site 932677003683 DNA binding site [nucleotide binding] 932677003684 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 932677003685 chaperone protein HchA; Provisional; Region: PRK04155 932677003686 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 932677003687 conserved cys residue [active] 932677003688 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932677003689 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932677003690 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 932677003691 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 932677003692 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 932677003693 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 932677003694 active site 932677003695 homotetramer interface [polypeptide binding]; other site 932677003696 lysozyme inhibitor; Provisional; Region: PRK11372 932677003697 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 932677003698 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 932677003699 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 932677003700 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 932677003701 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 932677003702 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 932677003703 active site 932677003704 HIGH motif; other site 932677003705 dimer interface [polypeptide binding]; other site 932677003706 KMSKS motif; other site 932677003707 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932677003708 RNA binding surface [nucleotide binding]; other site 932677003709 pyridoxamine kinase; Validated; Region: PRK05756 932677003710 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 932677003711 dimer interface [polypeptide binding]; other site 932677003712 pyridoxal binding site [chemical binding]; other site 932677003713 ATP binding site [chemical binding]; other site 932677003714 glutathionine S-transferase; Provisional; Region: PRK10542 932677003715 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 932677003716 C-terminal domain interface [polypeptide binding]; other site 932677003717 GSH binding site (G-site) [chemical binding]; other site 932677003718 dimer interface [polypeptide binding]; other site 932677003719 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 932677003720 dimer interface [polypeptide binding]; other site 932677003721 N-terminal domain interface [polypeptide binding]; other site 932677003722 substrate binding pocket (H-site) [chemical binding]; other site 932677003723 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 932677003724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677003725 putative substrate translocation pore; other site 932677003726 hypothetical protein; Validated; Region: PRK06186 932677003727 conserved cys residue [active] 932677003728 endonuclease III; Provisional; Region: PRK10702 932677003729 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 932677003730 minor groove reading motif; other site 932677003731 helix-hairpin-helix signature motif; other site 932677003732 substrate binding pocket [chemical binding]; other site 932677003733 active site 932677003734 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 932677003735 electron transport complex RsxE subunit; Provisional; Region: PRK12405 932677003736 electron transport complex protein RnfG; Validated; Region: PRK01908 932677003737 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 932677003738 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 932677003739 SLBB domain; Region: SLBB; pfam10531 932677003740 ferredoxin; Provisional; Region: PRK06991 932677003741 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 932677003742 electron transport complex protein RnfB; Provisional; Region: PRK05113 932677003743 Putative Fe-S cluster; Region: FeS; cl17515 932677003744 4Fe-4S binding domain; Region: Fer4; pfam00037 932677003745 electron transport complex protein RsxA; Provisional; Region: PRK05151 932677003746 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 932677003747 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 932677003748 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 932677003749 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 932677003750 putative ligand binding site [chemical binding]; other site 932677003751 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 932677003752 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 932677003753 Walker A/P-loop; other site 932677003754 ATP binding site [chemical binding]; other site 932677003755 Q-loop/lid; other site 932677003756 ABC transporter signature motif; other site 932677003757 Walker B; other site 932677003758 D-loop; other site 932677003759 H-loop/switch region; other site 932677003760 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 932677003761 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932677003762 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 932677003763 TM-ABC transporter signature motif; other site 932677003764 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932677003765 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 932677003766 TM-ABC transporter signature motif; other site 932677003767 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932677003768 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932677003769 metal binding site [ion binding]; metal-binding site 932677003770 active site 932677003771 I-site; other site 932677003772 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 932677003773 DNA binding site [nucleotide binding] 932677003774 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 932677003775 PapC N-terminal domain; Region: PapC_N; pfam13954 932677003776 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 932677003777 putative fimbrial chaperone protein; Provisional; Region: PRK09918 932677003778 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 932677003779 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 932677003780 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 932677003781 amidase catalytic site [active] 932677003782 Zn binding residues [ion binding]; other site 932677003783 substrate binding site [chemical binding]; other site 932677003784 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 932677003785 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 932677003786 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 932677003787 Na binding site [ion binding]; other site 932677003788 Cupin; Region: Cupin_6; pfam12852 932677003789 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677003790 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 932677003791 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677003792 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 932677003793 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 932677003794 putative NAD(P) binding site [chemical binding]; other site 932677003795 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 932677003796 Mechanosensitive ion channel; Region: MS_channel; pfam00924 932677003797 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 932677003798 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 932677003799 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 932677003800 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 932677003801 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932677003802 putative DNA binding site [nucleotide binding]; other site 932677003803 putative Zn2+ binding site [ion binding]; other site 932677003804 AsnC family; Region: AsnC_trans_reg; pfam01037 932677003805 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 932677003806 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 932677003807 inhibitor-cofactor binding pocket; inhibition site 932677003808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677003809 catalytic residue [active] 932677003810 Phosphotransferase enzyme family; Region: APH; pfam01636 932677003811 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 932677003812 active site 932677003813 ATP binding site [chemical binding]; other site 932677003814 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 932677003815 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677003816 motif II; other site 932677003817 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 932677003818 DNA-binding site [nucleotide binding]; DNA binding site 932677003819 RNA-binding motif; other site 932677003820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 932677003821 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 932677003822 CGNR zinc finger; Region: zf-CGNR; pfam11706 932677003823 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 932677003824 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 932677003825 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 932677003826 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 932677003827 active site 932677003828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677003829 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677003830 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 932677003831 putative substrate binding pocket [chemical binding]; other site 932677003832 putative dimerization interface [polypeptide binding]; other site 932677003833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932677003834 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 932677003835 NAD(P) binding site [chemical binding]; other site 932677003836 active site 932677003837 L-arabinose isomerase; Provisional; Region: PRK02929 932677003838 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 932677003839 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 932677003840 trimer interface [polypeptide binding]; other site 932677003841 putative substrate binding site [chemical binding]; other site 932677003842 putative metal binding site [ion binding]; other site 932677003843 ribulokinase; Provisional; Region: PRK04123 932677003844 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 932677003845 N- and C-terminal domain interface [polypeptide binding]; other site 932677003846 active site 932677003847 MgATP binding site [chemical binding]; other site 932677003848 catalytic site [active] 932677003849 metal binding site [ion binding]; metal-binding site 932677003850 carbohydrate binding site [chemical binding]; other site 932677003851 homodimer interface [polypeptide binding]; other site 932677003852 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 932677003853 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 932677003854 ligand binding site [chemical binding]; other site 932677003855 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 932677003856 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 932677003857 Walker A/P-loop; other site 932677003858 ATP binding site [chemical binding]; other site 932677003859 Q-loop/lid; other site 932677003860 ABC transporter signature motif; other site 932677003861 Walker B; other site 932677003862 D-loop; other site 932677003863 H-loop/switch region; other site 932677003864 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 932677003865 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 932677003866 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932677003867 TM-ABC transporter signature motif; other site 932677003868 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 932677003869 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 932677003870 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677003871 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677003872 putative oxidoreductase; Provisional; Region: PRK11579 932677003873 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932677003874 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 932677003875 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 932677003876 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 932677003877 active site 932677003878 purine riboside binding site [chemical binding]; other site 932677003879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 932677003880 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 932677003881 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 932677003882 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 932677003883 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 932677003884 fumarate hydratase; Reviewed; Region: fumC; PRK00485 932677003885 Class II fumarases; Region: Fumarase_classII; cd01362 932677003886 active site 932677003887 tetramer interface [polypeptide binding]; other site 932677003888 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 932677003889 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932677003890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677003891 putative substrate translocation pore; other site 932677003892 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 932677003893 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 932677003894 catalytic site [active] 932677003895 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 932677003896 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 932677003897 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 932677003898 HlyD family secretion protein; Region: HlyD_3; pfam13437 932677003899 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 932677003900 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677003901 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 932677003902 Virulence factor SrfB; Region: SrfB; pfam07520 932677003903 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 932677003904 benzoate transporter; Region: benE; TIGR00843 932677003905 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 932677003906 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932677003907 non-specific DNA binding site [nucleotide binding]; other site 932677003908 salt bridge; other site 932677003909 sequence-specific DNA binding site [nucleotide binding]; other site 932677003910 Isochorismatase family; Region: Isochorismatase; pfam00857 932677003911 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 932677003912 catalytic triad [active] 932677003913 conserved cis-peptide bond; other site 932677003914 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 932677003915 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 932677003916 N-terminal plug; other site 932677003917 ligand-binding site [chemical binding]; other site 932677003918 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 932677003919 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 932677003920 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 932677003921 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 932677003922 2-isopropylmalate synthase; Validated; Region: PRK03739 932677003923 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 932677003924 active site 932677003925 catalytic residues [active] 932677003926 metal binding site [ion binding]; metal-binding site 932677003927 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 932677003928 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 932677003929 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 932677003930 active site 932677003931 dimer interface [polypeptide binding]; other site 932677003932 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 932677003933 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 932677003934 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 932677003935 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 932677003936 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 932677003937 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 932677003938 FeS/SAM binding site; other site 932677003939 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 932677003940 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 932677003941 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 932677003942 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 932677003943 Uncharacterized conserved protein [Function unknown]; Region: COG2353 932677003944 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 932677003945 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 932677003946 active site 932677003947 ADP/pyrophosphate binding site [chemical binding]; other site 932677003948 dimerization interface [polypeptide binding]; other site 932677003949 allosteric effector site; other site 932677003950 fructose-1,6-bisphosphate binding site; other site 932677003951 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 932677003952 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 932677003953 intersubunit interface [polypeptide binding]; other site 932677003954 active site 932677003955 zinc binding site [ion binding]; other site 932677003956 Na+ binding site [ion binding]; other site 932677003957 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932677003958 active site 932677003959 phosphorylation site [posttranslational modification] 932677003960 AAA domain; Region: AAA_17; pfam13207 932677003961 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 932677003962 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 932677003963 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 932677003964 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 932677003965 trimer interface [polypeptide binding]; other site 932677003966 active site 932677003967 substrate binding site [chemical binding]; other site 932677003968 CoA binding site [chemical binding]; other site 932677003969 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 932677003970 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 932677003971 tetramer interface [polypeptide binding]; other site 932677003972 heme binding pocket [chemical binding]; other site 932677003973 NADPH binding site [chemical binding]; other site 932677003974 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 932677003975 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 932677003976 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 932677003977 ligand binding site [chemical binding]; other site 932677003978 dimerization interface [polypeptide binding]; other site 932677003979 zinc binding site [ion binding]; other site 932677003980 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 932677003981 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 932677003982 Walker A/P-loop; other site 932677003983 ATP binding site [chemical binding]; other site 932677003984 Q-loop/lid; other site 932677003985 ABC transporter signature motif; other site 932677003986 Walker B; other site 932677003987 D-loop; other site 932677003988 H-loop/switch region; other site 932677003989 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 932677003990 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932677003991 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 932677003992 TM-ABC transporter signature motif; other site 932677003993 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 932677003994 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932677003995 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932677003996 putative active site [active] 932677003997 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 932677003998 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 932677003999 substrate binding site [chemical binding]; other site 932677004000 ATP binding site [chemical binding]; other site 932677004001 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 932677004002 Prostaglandin dehydrogenases; Region: PGDH; cd05288 932677004003 NAD(P) binding site [chemical binding]; other site 932677004004 substrate binding site [chemical binding]; other site 932677004005 dimer interface [polypeptide binding]; other site 932677004006 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 932677004007 active site 932677004008 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 932677004009 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 932677004010 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 932677004011 HAMP domain; Region: HAMP; pfam00672 932677004012 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677004013 dimer interface [polypeptide binding]; other site 932677004014 putative CheW interface [polypeptide binding]; other site 932677004015 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 932677004016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677004017 active site 932677004018 phosphorylation site [posttranslational modification] 932677004019 dimerization interface [polypeptide binding]; other site 932677004020 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932677004021 DNA binding site [nucleotide binding] 932677004022 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 932677004023 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 932677004024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677004025 Walker A/P-loop; other site 932677004026 ATP binding site [chemical binding]; other site 932677004027 Q-loop/lid; other site 932677004028 ABC transporter signature motif; other site 932677004029 Walker B; other site 932677004030 D-loop; other site 932677004031 H-loop/switch region; other site 932677004032 maltose O-acetyltransferase; Provisional; Region: PRK10092 932677004033 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 932677004034 active site 932677004035 substrate binding site [chemical binding]; other site 932677004036 trimer interface [polypeptide binding]; other site 932677004037 CoA binding site [chemical binding]; other site 932677004038 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932677004039 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 932677004040 active site 932677004041 metal binding site [ion binding]; metal-binding site 932677004042 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677004043 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677004044 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 932677004045 putative effector binding pocket; other site 932677004046 putative dimerization interface [polypeptide binding]; other site 932677004047 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 932677004048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932677004049 NAD(P) binding site [chemical binding]; other site 932677004050 active site 932677004051 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677004052 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677004053 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_5; cd08426 932677004054 putative dimerization interface [polypeptide binding]; other site 932677004055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 932677004056 hypothetical protein; Provisional; Region: PRK10519 932677004057 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 932677004058 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 932677004059 metal binding site [ion binding]; metal-binding site 932677004060 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 932677004061 ArsC family; Region: ArsC; pfam03960 932677004062 catalytic residues [active] 932677004063 arsenical pump membrane protein; Provisional; Region: PRK15445 932677004064 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 932677004065 transmembrane helices; other site 932677004066 potential protein location (hypothetical protein) that overlaps protein (arsenical pump membrane protein ArsB) 932677004067 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932677004068 dimerization interface [polypeptide binding]; other site 932677004069 putative DNA binding site [nucleotide binding]; other site 932677004070 putative Zn2+ binding site [ion binding]; other site 932677004071 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 932677004072 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753 932677004073 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 932677004074 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333 932677004075 Xanthomonas XOO_2897-like deaminase; Region: XOO_2897-deam; pfam14440 932677004076 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 932677004077 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 932677004078 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 932677004079 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 932677004080 active site 932677004081 FMN binding site [chemical binding]; other site 932677004082 substrate binding site [chemical binding]; other site 932677004083 homotetramer interface [polypeptide binding]; other site 932677004084 catalytic residue [active] 932677004085 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 932677004086 Alkaline phosphatase homologues; Region: alkPPc; smart00098 932677004087 active site 932677004088 dimer interface [polypeptide binding]; other site 932677004089 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 932677004090 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 932677004091 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 932677004092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677004093 dimer interface [polypeptide binding]; other site 932677004094 conserved gate region; other site 932677004095 putative PBP binding loops; other site 932677004096 ABC-ATPase subunit interface; other site 932677004097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677004098 dimer interface [polypeptide binding]; other site 932677004099 conserved gate region; other site 932677004100 putative PBP binding loops; other site 932677004101 ABC-ATPase subunit interface; other site 932677004102 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 932677004103 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 932677004104 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 932677004105 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 932677004106 Walker A/P-loop; other site 932677004107 ATP binding site [chemical binding]; other site 932677004108 Q-loop/lid; other site 932677004109 ABC transporter signature motif; other site 932677004110 Walker B; other site 932677004111 D-loop; other site 932677004112 H-loop/switch region; other site 932677004113 TOBE domain; Region: TOBE_2; pfam08402 932677004114 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 932677004115 trimer interface; other site 932677004116 sugar binding site [chemical binding]; other site 932677004117 maltose regulon periplasmic protein; Provisional; Region: PRK10564 932677004118 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 932677004119 PGAP1-like protein; Region: PGAP1; pfam07819 932677004120 Helix-turn-helix domain; Region: HTH_18; pfam12833 932677004121 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 932677004122 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 932677004123 maltodextrin phosphorylase; Provisional; Region: PRK14985 932677004124 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 932677004125 active site pocket [active] 932677004126 transcriptional regulator MalT; Provisional; Region: PRK04841 932677004127 AAA ATPase domain; Region: AAA_16; pfam13191 932677004128 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 932677004129 DNA binding residues [nucleotide binding] 932677004130 dimerization interface [polypeptide binding]; other site 932677004131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677004132 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932677004133 putative substrate translocation pore; other site 932677004134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 932677004135 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 932677004136 putative oxidoreductase; Provisional; Region: PRK09939 932677004137 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 932677004138 putative molybdopterin cofactor binding site [chemical binding]; other site 932677004139 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 932677004140 putative molybdopterin cofactor binding site; other site 932677004141 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 932677004142 MgtC family; Region: MgtC; pfam02308 932677004143 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 932677004144 HTH-like domain; Region: HTH_21; pfam13276 932677004145 Integrase core domain; Region: rve; pfam00665 932677004146 Integrase core domain; Region: rve_3; pfam13683 932677004147 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 932677004148 hypothetical protein; Provisional; Region: PRK09946 932677004149 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 932677004150 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 932677004151 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 932677004152 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 932677004153 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932677004154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677004155 Walker A/P-loop; other site 932677004156 ATP binding site [chemical binding]; other site 932677004157 Q-loop/lid; other site 932677004158 ABC transporter signature motif; other site 932677004159 Walker B; other site 932677004160 D-loop; other site 932677004161 H-loop/switch region; other site 932677004162 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 932677004163 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 932677004164 HlyD family secretion protein; Region: HlyD_3; pfam13437 932677004165 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 932677004166 NlpC/P60 family; Region: NLPC_P60; pfam00877 932677004167 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 932677004168 nudix motif; other site 932677004169 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 932677004170 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 932677004171 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 932677004172 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 932677004173 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 932677004174 classical (c) SDRs; Region: SDR_c; cd05233 932677004175 NAD(P) binding site [chemical binding]; other site 932677004176 active site 932677004177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932677004178 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 932677004179 NAD(P) binding site [chemical binding]; other site 932677004180 active site 932677004181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677004182 benzoate transport; Region: 2A0115; TIGR00895 932677004183 putative substrate translocation pore; other site 932677004184 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 932677004185 active site 932677004186 catalytic site [active] 932677004187 Zn binding site [ion binding]; other site 932677004188 tetramer interface [polypeptide binding]; other site 932677004189 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 932677004190 hypothetical protein; Provisional; Region: PRK06102 932677004191 Amidase; Region: Amidase; cl11426 932677004192 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932677004193 DNA-binding site [nucleotide binding]; DNA binding site 932677004194 Transcriptional regulators [Transcription]; Region: GntR; COG1802 932677004195 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 932677004196 DNA-binding site [nucleotide binding]; DNA binding site 932677004197 FCD domain; Region: FCD; pfam07729 932677004198 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 932677004199 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 932677004200 homotrimer interaction site [polypeptide binding]; other site 932677004201 putative active site [active] 932677004202 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 932677004203 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 932677004204 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 932677004205 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 932677004206 NAD(P) binding site [chemical binding]; other site 932677004207 catalytic residues [active] 932677004208 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 932677004209 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 932677004210 dimer interface [polypeptide binding]; other site 932677004211 active site 932677004212 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 932677004213 substrate binding site [chemical binding]; other site 932677004214 catalytic residue [active] 932677004215 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677004216 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677004217 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 932677004218 dimerization interface [polypeptide binding]; other site 932677004219 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 932677004220 Fasciclin domain; Region: Fasciclin; pfam02469 932677004221 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 932677004222 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 932677004223 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 932677004224 DNA binding residues [nucleotide binding] 932677004225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 932677004226 Anti-sigma-K factor rskA; Region: RskA; pfam10099 932677004227 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 932677004228 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677004229 dimer interface [polypeptide binding]; other site 932677004230 putative CheW interface [polypeptide binding]; other site 932677004231 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 932677004232 potassium uptake protein; Region: kup; TIGR00794 932677004233 HipA N-terminal domain; Region: Couple_hipA; pfam13657 932677004234 HipA-like N-terminal domain; Region: HipA_N; pfam07805 932677004235 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 932677004236 HipA-like C-terminal domain; Region: HipA_C; pfam07804 932677004237 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 932677004238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932677004239 non-specific DNA binding site [nucleotide binding]; other site 932677004240 salt bridge; other site 932677004241 sequence-specific DNA binding site [nucleotide binding]; other site 932677004242 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677004243 Coenzyme A binding pocket [chemical binding]; other site 932677004244 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 932677004245 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 932677004246 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 932677004247 putative symporter YagG; Provisional; Region: PRK09669 932677004248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677004249 putative substrate translocation pore; other site 932677004250 Autoinducer synthetase; Region: Autoind_synth; pfam00765 932677004251 Autoinducer binding domain; Region: Autoind_bind; pfam03472 932677004252 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 932677004253 DNA binding residues [nucleotide binding] 932677004254 dimerization interface [polypeptide binding]; other site 932677004255 short chain dehydrogenase; Provisional; Region: PRK06701 932677004256 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 932677004257 NAD binding site [chemical binding]; other site 932677004258 metal binding site [ion binding]; metal-binding site 932677004259 active site 932677004260 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 932677004261 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 932677004262 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 932677004263 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 932677004264 hypothetical protein; Provisional; Region: PRK07236 932677004265 FAD binding domain; Region: FAD_binding_3; pfam01494 932677004266 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 932677004267 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 932677004268 active site 932677004269 Zn binding site [ion binding]; other site 932677004270 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 932677004271 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 932677004272 XdhC Rossmann domain; Region: XdhC_C; pfam13478 932677004273 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 932677004274 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 932677004275 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 932677004276 guanine deaminase; Provisional; Region: PRK09228 932677004277 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 932677004278 active site 932677004279 malonic semialdehyde reductase; Provisional; Region: PRK10538 932677004280 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 932677004281 putative NAD(P) binding site [chemical binding]; other site 932677004282 homodimer interface [polypeptide binding]; other site 932677004283 homotetramer interface [polypeptide binding]; other site 932677004284 active site 932677004285 hypothetical protein; Provisional; Region: PRK02237 932677004286 hypothetical protein; Provisional; Region: PRK13659 932677004287 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 932677004288 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932677004289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677004290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677004291 dimer interface [polypeptide binding]; other site 932677004292 conserved gate region; other site 932677004293 putative PBP binding loops; other site 932677004294 ABC-ATPase subunit interface; other site 932677004295 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 932677004296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677004297 dimer interface [polypeptide binding]; other site 932677004298 conserved gate region; other site 932677004299 ABC-ATPase subunit interface; other site 932677004300 potential protein location (hypothetical protein) that overlaps protein (glycine betaine/carnitine/choline transport system permease protein OpuCB) 932677004301 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 932677004302 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 932677004303 Walker A/P-loop; other site 932677004304 ATP binding site [chemical binding]; other site 932677004305 Q-loop/lid; other site 932677004306 ABC transporter signature motif; other site 932677004307 Walker B; other site 932677004308 D-loop; other site 932677004309 H-loop/switch region; other site 932677004310 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 932677004311 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 932677004312 AAA domain; Region: AAA_26; pfam13500 932677004313 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932677004314 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932677004315 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 932677004316 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677004317 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 932677004318 dimerization interface [polypeptide binding]; other site 932677004319 substrate binding pocket [chemical binding]; other site 932677004320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677004321 putative substrate translocation pore; other site 932677004322 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 932677004323 putative arabinose transporter; Provisional; Region: PRK03545 932677004324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677004325 putative substrate translocation pore; other site 932677004326 hypothetical protein; Provisional; Region: PRK11019 932677004327 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 932677004328 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 932677004329 peptide binding site [polypeptide binding]; other site 932677004330 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 932677004331 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 932677004332 metal binding site [ion binding]; metal-binding site 932677004333 dimer interface [polypeptide binding]; other site 932677004334 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 932677004335 HAMP domain; Region: HAMP; pfam00672 932677004336 dimerization interface [polypeptide binding]; other site 932677004337 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677004338 dimer interface [polypeptide binding]; other site 932677004339 putative CheW interface [polypeptide binding]; other site 932677004340 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 932677004341 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 932677004342 substrate binding pocket [chemical binding]; other site 932677004343 catalytic triad [active] 932677004344 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 932677004345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 932677004346 benzoate transport; Region: 2A0115; TIGR00895 932677004347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677004348 putative substrate translocation pore; other site 932677004349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677004350 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 932677004351 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677004352 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 932677004353 dimerization interface [polypeptide binding]; other site 932677004354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 932677004355 Smr domain; Region: Smr; pfam01713 932677004356 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 932677004357 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 932677004358 ligand binding site [chemical binding]; other site 932677004359 flexible hinge region; other site 932677004360 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 932677004361 putative switch regulator; other site 932677004362 non-specific DNA interactions [nucleotide binding]; other site 932677004363 DNA binding site [nucleotide binding] 932677004364 sequence specific DNA binding site [nucleotide binding]; other site 932677004365 putative cAMP binding site [chemical binding]; other site 932677004366 universal stress protein UspE; Provisional; Region: PRK11175 932677004367 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 932677004368 Ligand Binding Site [chemical binding]; other site 932677004369 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 932677004370 Ligand Binding Site [chemical binding]; other site 932677004371 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 932677004372 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 932677004373 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 932677004374 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 932677004375 ligand binding site [chemical binding]; other site 932677004376 homodimer interface [polypeptide binding]; other site 932677004377 NAD(P) binding site [chemical binding]; other site 932677004378 trimer interface B [polypeptide binding]; other site 932677004379 trimer interface A [polypeptide binding]; other site 932677004380 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 932677004381 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 932677004382 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 932677004383 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 932677004384 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 932677004385 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 932677004386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677004387 active site 932677004388 phosphorylation site [posttranslational modification] 932677004389 intermolecular recognition site; other site 932677004390 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932677004391 DNA binding site [nucleotide binding] 932677004392 sensor protein RstB; Provisional; Region: PRK10604 932677004393 HAMP domain; Region: HAMP; pfam00672 932677004394 dimerization interface [polypeptide binding]; other site 932677004395 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932677004396 dimer interface [polypeptide binding]; other site 932677004397 phosphorylation site [posttranslational modification] 932677004398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677004399 ATP binding site [chemical binding]; other site 932677004400 Mg2+ binding site [ion binding]; other site 932677004401 G-X-G motif; other site 932677004402 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 932677004403 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 932677004404 active site 932677004405 Zn binding site [ion binding]; other site 932677004406 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 932677004407 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 932677004408 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932677004409 ATP binding site [chemical binding]; other site 932677004410 putative Mg++ binding site [ion binding]; other site 932677004411 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932677004412 nucleotide binding region [chemical binding]; other site 932677004413 ATP-binding site [chemical binding]; other site 932677004414 Helicase associated domain (HA2); Region: HA2; pfam04408 932677004415 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 932677004416 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 932677004417 azoreductase; Reviewed; Region: PRK00170 932677004418 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 932677004419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 932677004420 hypothetical protein; Provisional; Region: PRK10695 932677004421 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 932677004422 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 932677004423 putative ligand binding site [chemical binding]; other site 932677004424 putative NAD binding site [chemical binding]; other site 932677004425 catalytic site [active] 932677004426 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 932677004427 Domain of unknown function (DUF333); Region: DUF333; pfam03891 932677004428 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 932677004429 MgtC family; Region: MgtC; pfam02308 932677004430 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 932677004431 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 932677004432 Ligand Binding Site [chemical binding]; other site 932677004433 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 932677004434 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 932677004435 Cl binding site [ion binding]; other site 932677004436 oligomer interface [polypeptide binding]; other site 932677004437 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 932677004438 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 932677004439 peptide binding site [polypeptide binding]; other site 932677004440 murein peptide amidase A; Provisional; Region: PRK10602 932677004441 active site 932677004442 Zn binding site [ion binding]; other site 932677004443 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 932677004444 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 932677004445 active site 932677004446 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 932677004447 dimer interface [polypeptide binding]; other site 932677004448 catalytic triad [active] 932677004449 peroxidatic and resolving cysteines [active] 932677004450 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 932677004451 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 932677004452 putative aromatic amino acid binding site; other site 932677004453 PAS domain; Region: PAS; smart00091 932677004454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677004455 Walker A motif; other site 932677004456 ATP binding site [chemical binding]; other site 932677004457 Walker B motif; other site 932677004458 arginine finger; other site 932677004459 hypothetical protein; Provisional; Region: PRK05415 932677004460 Domain of unknown function (DUF697); Region: DUF697; cl12064 932677004461 Predicted ATPase [General function prediction only]; Region: COG3106 932677004462 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 932677004463 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 932677004464 phage shock protein C; Region: phageshock_pspC; TIGR02978 932677004465 phage shock protein B; Provisional; Region: pspB; PRK09458 932677004466 phage shock protein PspA; Provisional; Region: PRK10698 932677004467 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 932677004468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677004469 Walker A motif; other site 932677004470 ATP binding site [chemical binding]; other site 932677004471 Walker B motif; other site 932677004472 arginine finger; other site 932677004473 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 932677004474 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 932677004475 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 932677004476 peptide binding site [polypeptide binding]; other site 932677004477 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 932677004478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677004479 dimer interface [polypeptide binding]; other site 932677004480 conserved gate region; other site 932677004481 putative PBP binding loops; other site 932677004482 ABC-ATPase subunit interface; other site 932677004483 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 932677004484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677004485 dimer interface [polypeptide binding]; other site 932677004486 conserved gate region; other site 932677004487 putative PBP binding loops; other site 932677004488 ABC-ATPase subunit interface; other site 932677004489 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 932677004490 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932677004491 Walker A/P-loop; other site 932677004492 ATP binding site [chemical binding]; other site 932677004493 Q-loop/lid; other site 932677004494 ABC transporter signature motif; other site 932677004495 Walker B; other site 932677004496 D-loop; other site 932677004497 H-loop/switch region; other site 932677004498 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 932677004499 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 932677004500 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932677004501 Walker A/P-loop; other site 932677004502 ATP binding site [chemical binding]; other site 932677004503 Q-loop/lid; other site 932677004504 ABC transporter signature motif; other site 932677004505 Walker B; other site 932677004506 D-loop; other site 932677004507 H-loop/switch region; other site 932677004508 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 932677004509 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 932677004510 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 932677004511 NAD binding site [chemical binding]; other site 932677004512 homotetramer interface [polypeptide binding]; other site 932677004513 homodimer interface [polypeptide binding]; other site 932677004514 substrate binding site [chemical binding]; other site 932677004515 active site 932677004516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 932677004517 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 932677004518 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677004519 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 932677004520 dimerization interface [polypeptide binding]; other site 932677004521 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 932677004522 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 932677004523 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 932677004524 active site turn [active] 932677004525 phosphorylation site [posttranslational modification] 932677004526 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 932677004527 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 932677004528 putative molybdopterin cofactor binding site [chemical binding]; other site 932677004529 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 932677004530 putative molybdopterin cofactor binding site; other site 932677004531 exoribonuclease II; Provisional; Region: PRK05054 932677004532 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 932677004533 RNB domain; Region: RNB; pfam00773 932677004534 S1 RNA binding domain; Region: S1; pfam00575 932677004535 carbon starvation protein A; Provisional; Region: PRK15015 932677004536 Carbon starvation protein CstA; Region: CstA; pfam02554 932677004537 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 932677004538 Uncharacterized small protein [Function unknown]; Region: COG2879 932677004539 RNase II stability modulator; Provisional; Region: PRK10060 932677004540 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932677004541 putative active site [active] 932677004542 heme pocket [chemical binding]; other site 932677004543 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932677004544 metal binding site [ion binding]; metal-binding site 932677004545 active site 932677004546 I-site; other site 932677004547 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932677004548 enoyl-CoA hydratase; Validated; Region: PRK08788 932677004549 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 932677004550 substrate binding site [chemical binding]; other site 932677004551 oxyanion hole (OAH) forming residues; other site 932677004552 trimer interface [polypeptide binding]; other site 932677004553 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 932677004554 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 932677004555 intersubunit interface [polypeptide binding]; other site 932677004556 active site 932677004557 Zn2+ binding site [ion binding]; other site 932677004558 lipoprotein; Provisional; Region: PRK10540 932677004559 translation initiation factor Sui1; Validated; Region: PRK06824 932677004560 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 932677004561 putative rRNA binding site [nucleotide binding]; other site 932677004562 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 932677004563 active site 932677004564 dimer interface [polypeptide binding]; other site 932677004565 tetratricopeptide repeat protein; Provisional; Region: PRK11788 932677004566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 932677004567 TPR motif; other site 932677004568 binding surface 932677004569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932677004570 binding surface 932677004571 TPR motif; other site 932677004572 Predicted membrane protein [Function unknown]; Region: COG3771 932677004573 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 932677004574 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 932677004575 active site 932677004576 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 932677004577 dimerization interface [polypeptide binding]; other site 932677004578 active site 932677004579 aconitate hydratase; Validated; Region: PRK09277 932677004580 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 932677004581 substrate binding site [chemical binding]; other site 932677004582 ligand binding site [chemical binding]; other site 932677004583 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 932677004584 substrate binding site [chemical binding]; other site 932677004585 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 932677004586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677004587 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 932677004588 substrate binding site [chemical binding]; other site 932677004589 putative dimerization interface [polypeptide binding]; other site 932677004590 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 932677004591 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 932677004592 active site 932677004593 interdomain interaction site; other site 932677004594 putative metal-binding site [ion binding]; other site 932677004595 nucleotide binding site [chemical binding]; other site 932677004596 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 932677004597 domain I; other site 932677004598 DNA binding groove [nucleotide binding] 932677004599 phosphate binding site [ion binding]; other site 932677004600 domain II; other site 932677004601 domain III; other site 932677004602 nucleotide binding site [chemical binding]; other site 932677004603 catalytic site [active] 932677004604 domain IV; other site 932677004605 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 932677004606 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 932677004607 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 932677004608 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 932677004609 hypothetical protein; Provisional; Region: PRK11037 932677004610 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 932677004611 putative inner membrane peptidase; Provisional; Region: PRK11778 932677004612 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 932677004613 tandem repeat interface [polypeptide binding]; other site 932677004614 oligomer interface [polypeptide binding]; other site 932677004615 active site residues [active] 932677004616 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 932677004617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932677004618 NAD(P) binding site [chemical binding]; other site 932677004619 active site 932677004620 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 932677004621 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 932677004622 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 932677004623 homodimer interface [polypeptide binding]; other site 932677004624 Walker A motif; other site 932677004625 ATP binding site [chemical binding]; other site 932677004626 hydroxycobalamin binding site [chemical binding]; other site 932677004627 Walker B motif; other site 932677004628 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 932677004629 Citrate transporter; Region: CitMHS; pfam03600 932677004630 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 932677004631 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932677004632 RNA binding surface [nucleotide binding]; other site 932677004633 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 932677004634 probable active site [active] 932677004635 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 932677004636 hypothetical protein; Provisional; Region: PRK11630 932677004637 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 932677004638 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 932677004639 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 932677004640 anthranilate synthase component I; Provisional; Region: PRK13564 932677004641 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 932677004642 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 932677004643 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 932677004644 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 932677004645 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 932677004646 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 932677004647 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 932677004648 active site 932677004649 ribulose/triose binding site [chemical binding]; other site 932677004650 phosphate binding site [ion binding]; other site 932677004651 substrate (anthranilate) binding pocket [chemical binding]; other site 932677004652 product (indole) binding pocket [chemical binding]; other site 932677004653 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 932677004654 active site 932677004655 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 932677004656 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 932677004657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677004658 catalytic residue [active] 932677004659 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 932677004660 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 932677004661 substrate binding site [chemical binding]; other site 932677004662 active site 932677004663 catalytic residues [active] 932677004664 heterodimer interface [polypeptide binding]; other site 932677004665 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 932677004666 BON domain; Region: BON; pfam04972 932677004667 outer membrane protein W; Provisional; Region: PRK10959 932677004668 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 932677004669 hypothetical protein; Provisional; Region: PRK02868 932677004670 intracellular septation protein A; Reviewed; Region: PRK00259 932677004671 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 932677004672 transport protein TonB; Provisional; Region: PRK10819 932677004673 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 932677004674 YciI-like protein; Reviewed; Region: PRK11370 932677004675 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 932677004676 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 932677004677 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 932677004678 putative active site [active] 932677004679 catalytic site [active] 932677004680 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 932677004681 putative active site [active] 932677004682 catalytic site [active] 932677004683 dsDNA-mimic protein; Reviewed; Region: PRK05094 932677004684 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 932677004685 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932677004686 Walker A/P-loop; other site 932677004687 ATP binding site [chemical binding]; other site 932677004688 Q-loop/lid; other site 932677004689 ABC transporter signature motif; other site 932677004690 Walker B; other site 932677004691 D-loop; other site 932677004692 H-loop/switch region; other site 932677004693 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 932677004694 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 932677004695 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932677004696 Walker A/P-loop; other site 932677004697 ATP binding site [chemical binding]; other site 932677004698 Q-loop/lid; other site 932677004699 ABC transporter signature motif; other site 932677004700 Walker B; other site 932677004701 D-loop; other site 932677004702 H-loop/switch region; other site 932677004703 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 932677004704 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 932677004705 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 932677004706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677004707 dimer interface [polypeptide binding]; other site 932677004708 conserved gate region; other site 932677004709 ABC-ATPase subunit interface; other site 932677004710 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 932677004711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677004712 dimer interface [polypeptide binding]; other site 932677004713 conserved gate region; other site 932677004714 putative PBP binding loops; other site 932677004715 ABC-ATPase subunit interface; other site 932677004716 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 932677004717 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 932677004718 peptide binding site [polypeptide binding]; other site 932677004719 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 932677004720 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 932677004721 peptide binding site [polypeptide binding]; other site 932677004722 hypothetical protein; Provisional; Region: PRK11111 932677004723 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 932677004724 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 932677004725 putative catalytic cysteine [active] 932677004726 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 932677004727 putative active site [active] 932677004728 metal binding site [ion binding]; metal-binding site 932677004729 thymidine kinase; Provisional; Region: PRK04296 932677004730 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 932677004731 ATP binding site [chemical binding]; other site 932677004732 Walker A motif; other site 932677004733 Walker B motif; other site 932677004734 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 932677004735 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 932677004736 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 932677004737 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 932677004738 putative NAD(P) binding site [chemical binding]; other site 932677004739 active site 932677004740 putative substrate binding site [chemical binding]; other site 932677004741 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 932677004742 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 932677004743 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 932677004744 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 932677004745 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 932677004746 active site 932677004747 tetramer interface; other site 932677004748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677004749 active site 932677004750 response regulator of RpoS; Provisional; Region: PRK10693 932677004751 phosphorylation site [posttranslational modification] 932677004752 intermolecular recognition site; other site 932677004753 dimerization interface [polypeptide binding]; other site 932677004754 hypothetical protein; Provisional; Region: PRK10279 932677004755 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 932677004756 active site 932677004757 nucleophile elbow; other site 932677004758 hypothetical protein; Provisional; Region: PRK01617 932677004759 SEC-C motif; Region: SEC-C; pfam02810 932677004760 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 932677004761 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 932677004762 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 932677004763 putative active site [active] 932677004764 putative substrate binding site [chemical binding]; other site 932677004765 putative cosubstrate binding site; other site 932677004766 catalytic site [active] 932677004767 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 932677004768 putative catalytic site [active] 932677004769 putative phosphate binding site [ion binding]; other site 932677004770 active site 932677004771 metal binding site A [ion binding]; metal-binding site 932677004772 DNA binding site [nucleotide binding] 932677004773 putative AP binding site [nucleotide binding]; other site 932677004774 putative metal binding site B [ion binding]; other site 932677004775 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 932677004776 DNA topoisomerase III; Provisional; Region: PRK07726 932677004777 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 932677004778 active site 932677004779 putative interdomain interaction site [polypeptide binding]; other site 932677004780 putative metal-binding site [ion binding]; other site 932677004781 putative nucleotide binding site [chemical binding]; other site 932677004782 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 932677004783 domain I; other site 932677004784 DNA binding groove [nucleotide binding] 932677004785 phosphate binding site [ion binding]; other site 932677004786 domain II; other site 932677004787 domain III; other site 932677004788 nucleotide binding site [chemical binding]; other site 932677004789 catalytic site [active] 932677004790 domain IV; other site 932677004791 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 932677004792 putative FMN binding site [chemical binding]; other site 932677004793 protease 4; Provisional; Region: PRK10949 932677004794 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 932677004795 tandem repeat interface [polypeptide binding]; other site 932677004796 oligomer interface [polypeptide binding]; other site 932677004797 active site residues [active] 932677004798 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 932677004799 tandem repeat interface [polypeptide binding]; other site 932677004800 oligomer interface [polypeptide binding]; other site 932677004801 active site residues [active] 932677004802 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 932677004803 active site 932677004804 homodimer interface [polypeptide binding]; other site 932677004805 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 932677004806 Isochorismatase family; Region: Isochorismatase; pfam00857 932677004807 catalytic triad [active] 932677004808 metal binding site [ion binding]; metal-binding site 932677004809 conserved cis-peptide bond; other site 932677004810 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 932677004811 methionine sulfoxide reductase B; Provisional; Region: PRK00222 932677004812 SelR domain; Region: SelR; pfam01641 932677004813 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 932677004814 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 932677004815 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 932677004816 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 932677004817 active site 932677004818 phosphate binding residues; other site 932677004819 catalytic residues [active] 932677004820 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932677004821 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932677004822 active site 932677004823 catalytic tetrad [active] 932677004824 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 932677004825 PrkA family serine protein kinase; Provisional; Region: PRK15455 932677004826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677004827 Walker A motif; other site 932677004828 ATP binding site [chemical binding]; other site 932677004829 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 932677004830 hypothetical protein; Provisional; Region: PRK05325 932677004831 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 932677004832 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 932677004833 TrkA-C domain; Region: TrkA_C; pfam02080 932677004834 Transporter associated domain; Region: CorC_HlyC; smart01091 932677004835 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 932677004836 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 932677004837 Bacterial sugar transferase; Region: Bac_transf; pfam02397 932677004838 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 932677004839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677004840 putative substrate translocation pore; other site 932677004841 alanine racemase; Reviewed; Region: dadX; PRK03646 932677004842 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 932677004843 active site 932677004844 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 932677004845 substrate binding site [chemical binding]; other site 932677004846 catalytic residues [active] 932677004847 dimer interface [polypeptide binding]; other site 932677004848 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 932677004849 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932677004850 hydroxyglutarate oxidase; Provisional; Region: PRK11728 932677004851 SpoVR family protein; Provisional; Region: PRK11767 932677004852 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 932677004853 fatty acid metabolism regulator; Provisional; Region: PRK04984 932677004854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932677004855 DNA-binding site [nucleotide binding]; DNA binding site 932677004856 FadR C-terminal domain; Region: FadR_C; pfam07840 932677004857 disulfide bond formation protein B; Provisional; Region: PRK01749 932677004858 hypothetical protein; Provisional; Region: PRK05170 932677004859 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 932677004860 hypothetical protein; Provisional; Region: PRK10691 932677004861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 932677004862 septum formation inhibitor; Reviewed; Region: minC; PRK03511 932677004863 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 932677004864 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 932677004865 cell division inhibitor MinD; Provisional; Region: PRK10818 932677004866 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 932677004867 Switch I; other site 932677004868 Switch II; other site 932677004869 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 932677004870 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 932677004871 HRDC domain; Region: HRDC; cl02578 932677004872 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 932677004873 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 932677004874 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 932677004875 acyl-activating enzyme (AAE) consensus motif; other site 932677004876 putative AMP binding site [chemical binding]; other site 932677004877 putative active site [active] 932677004878 putative CoA binding site [chemical binding]; other site 932677004879 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 932677004880 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 932677004881 Glycoprotease family; Region: Peptidase_M22; pfam00814 932677004882 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 932677004883 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 932677004884 DEAD_2; Region: DEAD_2; pfam06733 932677004885 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 932677004886 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 932677004887 homotrimer interaction site [polypeptide binding]; other site 932677004888 putative active site [active] 932677004889 hypothetical protein; Provisional; Region: PRK05114 932677004890 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 932677004891 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 932677004892 chorismate binding enzyme; Region: Chorismate_bind; cl10555 932677004893 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 932677004894 putative active site [active] 932677004895 putative CoA binding site [chemical binding]; other site 932677004896 nudix motif; other site 932677004897 metal binding site [ion binding]; metal-binding site 932677004898 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 932677004899 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 932677004900 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 932677004901 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 932677004902 phage resistance protein; Provisional; Region: PRK10551 932677004903 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932677004904 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 932677004905 FOG: CBS domain [General function prediction only]; Region: COG0517 932677004906 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 932677004907 Transporter associated domain; Region: CorC_HlyC; smart01091 932677004908 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 932677004909 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 932677004910 active pocket/dimerization site; other site 932677004911 active site 932677004912 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 932677004913 active site 932677004914 phosphorylation site [posttranslational modification] 932677004915 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 932677004916 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 932677004917 hypothetical protein; Provisional; Region: PRK02913 932677004918 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 932677004919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677004920 S-adenosylmethionine binding site [chemical binding]; other site 932677004921 YebO-like protein; Region: YebO; pfam13974 932677004922 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 932677004923 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932677004924 putative DNA binding site [nucleotide binding]; other site 932677004925 putative Zn2+ binding site [ion binding]; other site 932677004926 Bacterial transcriptional regulator; Region: IclR; pfam01614 932677004927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677004928 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932677004929 putative substrate translocation pore; other site 932677004930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677004931 heat shock protein HtpX; Provisional; Region: PRK05457 932677004932 carboxy-terminal protease; Provisional; Region: PRK11186 932677004933 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 932677004934 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 932677004935 protein binding site [polypeptide binding]; other site 932677004936 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 932677004937 Catalytic dyad [active] 932677004938 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 932677004939 ProP expression regulator; Provisional; Region: PRK04950 932677004940 ProQ/FINO family; Region: ProQ; pfam04352 932677004941 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 932677004942 GAF domain; Region: GAF_2; pfam13185 932677004943 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 932677004944 Paraquat-inducible protein A; Region: PqiA; pfam04403 932677004945 Paraquat-inducible protein A; Region: PqiA; pfam04403 932677004946 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 932677004947 mce related protein; Region: MCE; pfam02470 932677004948 mce related protein; Region: MCE; pfam02470 932677004949 mce related protein; Region: MCE; pfam02470 932677004950 mce related protein; Region: MCE; pfam02470 932677004951 mce related protein; Region: MCE; pfam02470 932677004952 mce related protein; Region: MCE; pfam02470 932677004953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677004954 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 932677004955 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 932677004956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677004957 putative substrate translocation pore; other site 932677004958 choline transport protein BetT; Provisional; Region: PRK09928 932677004959 transcriptional regulator BetI; Validated; Region: PRK00767 932677004960 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932677004961 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 932677004962 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 932677004963 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 932677004964 NAD(P) binding site [chemical binding]; other site 932677004965 catalytic residues [active] 932677004966 choline dehydrogenase; Validated; Region: PRK02106 932677004967 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 932677004968 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 932677004969 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 932677004970 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 932677004971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677004972 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 932677004973 dimerization interface [polypeptide binding]; other site 932677004974 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 932677004975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932677004976 NAD(P) binding site [chemical binding]; other site 932677004977 active site 932677004978 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 932677004979 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 932677004980 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677004981 dimer interface [polypeptide binding]; other site 932677004982 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 932677004983 putative CheW interface [polypeptide binding]; other site 932677004984 MEKHLA domain; Region: MEKHLA; pfam08670 932677004985 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 932677004986 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 932677004987 NAD binding site [chemical binding]; other site 932677004988 sugar binding site [chemical binding]; other site 932677004989 divalent metal binding site [ion binding]; other site 932677004990 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 932677004991 dimer interface [polypeptide binding]; other site 932677004992 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 932677004993 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 932677004994 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 932677004995 active site turn [active] 932677004996 phosphorylation site [posttranslational modification] 932677004997 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 932677004998 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932677004999 DNA-binding site [nucleotide binding]; DNA binding site 932677005000 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 932677005001 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 932677005002 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677005003 dimer interface [polypeptide binding]; other site 932677005004 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 932677005005 putative CheW interface [polypeptide binding]; other site 932677005006 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 932677005007 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 932677005008 CopC domain; Region: CopC; pfam04234 932677005009 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 932677005010 exodeoxyribonuclease X; Provisional; Region: PRK07983 932677005011 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 932677005012 active site 932677005013 catalytic site [active] 932677005014 substrate binding site [chemical binding]; other site 932677005015 protease 2; Provisional; Region: PRK10115 932677005016 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 932677005017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 932677005018 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 932677005019 putative metal binding site [ion binding]; other site 932677005020 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 932677005021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932677005022 ATP-grasp domain; Region: ATP-grasp; pfam02222 932677005023 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 932677005024 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 932677005025 active site 932677005026 intersubunit interface [polypeptide binding]; other site 932677005027 catalytic residue [active] 932677005028 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 932677005029 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 932677005030 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 932677005031 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 932677005032 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932677005033 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932677005034 putative active site [active] 932677005035 pyruvate kinase; Provisional; Region: PRK05826 932677005036 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 932677005037 domain interfaces; other site 932677005038 active site 932677005039 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 932677005040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677005041 putative substrate translocation pore; other site 932677005042 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 932677005043 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 932677005044 putative acyl-acceptor binding pocket; other site 932677005045 putative peptidase; Provisional; Region: PRK11649 932677005046 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932677005047 Peptidase family M23; Region: Peptidase_M23; pfam01551 932677005048 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 932677005049 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 932677005050 metal binding site [ion binding]; metal-binding site 932677005051 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 932677005052 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 932677005053 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 932677005054 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932677005055 ABC-ATPase subunit interface; other site 932677005056 dimer interface [polypeptide binding]; other site 932677005057 putative PBP binding regions; other site 932677005058 Holliday junction DNA helicase, RuvB subunit; Region: ruvB; TIGR00635 932677005059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677005060 Walker A motif; other site 932677005061 ATP binding site [chemical binding]; other site 932677005062 Walker B motif; other site 932677005063 arginine finger; other site 932677005064 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 932677005065 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 932677005066 RuvA N terminal domain; Region: RuvA_N; pfam01330 932677005067 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 932677005068 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 932677005069 active site 932677005070 putative DNA-binding cleft [nucleotide binding]; other site 932677005071 dimer interface [polypeptide binding]; other site 932677005072 hypothetical protein; Validated; Region: PRK00110 932677005073 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 932677005074 nudix motif; other site 932677005075 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 932677005076 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 932677005077 dimer interface [polypeptide binding]; other site 932677005078 anticodon binding site; other site 932677005079 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 932677005080 homodimer interface [polypeptide binding]; other site 932677005081 motif 1; other site 932677005082 active site 932677005083 motif 2; other site 932677005084 GAD domain; Region: GAD; pfam02938 932677005085 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 932677005086 active site 932677005087 motif 3; other site 932677005088 Protein of unknown function DUF72; Region: DUF72; cl00777 932677005089 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 932677005090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677005091 S-adenosylmethionine binding site [chemical binding]; other site 932677005092 Methyltransferase domain; Region: Methyltransf_31; pfam13847 932677005093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677005094 S-adenosylmethionine binding site [chemical binding]; other site 932677005095 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 932677005096 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 932677005097 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 932677005098 dimer interface [polypeptide binding]; other site 932677005099 active site 932677005100 metal binding site [ion binding]; metal-binding site 932677005101 copper homeostasis protein CutC; Provisional; Region: PRK11572 932677005102 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 932677005103 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932677005104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677005105 homodimer interface [polypeptide binding]; other site 932677005106 catalytic residue [active] 932677005107 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 932677005108 putative metal binding site [ion binding]; other site 932677005109 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 932677005110 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 932677005111 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 932677005112 active site 932677005113 HIGH motif; other site 932677005114 KMSK motif region; other site 932677005115 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 932677005116 tRNA binding surface [nucleotide binding]; other site 932677005117 anticodon binding site; other site 932677005118 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 932677005119 amphipathic channel; other site 932677005120 Asn-Pro-Ala signature motifs; other site 932677005121 Flagellar protein FlhE; Region: FlhE; pfam06366 932677005122 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 932677005123 FHIPEP family; Region: FHIPEP; pfam00771 932677005124 flagellar biosynthetic protein FlhB; Region: flhB; TIGR00328 932677005125 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 932677005126 chemotaxis regulator CheZ; Provisional; Region: PRK11166 932677005127 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 932677005128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677005129 active site 932677005130 phosphorylation site [posttranslational modification] 932677005131 intermolecular recognition site; other site 932677005132 dimerization interface [polypeptide binding]; other site 932677005133 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 932677005134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677005135 active site 932677005136 phosphorylation site [posttranslational modification] 932677005137 intermolecular recognition site; other site 932677005138 dimerization interface [polypeptide binding]; other site 932677005139 CheB methylesterase; Region: CheB_methylest; pfam01339 932677005140 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 932677005141 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 932677005142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677005143 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 932677005144 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 932677005145 dimer interface [polypeptide binding]; other site 932677005146 ligand binding site [chemical binding]; other site 932677005147 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932677005148 dimerization interface [polypeptide binding]; other site 932677005149 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677005150 dimer interface [polypeptide binding]; other site 932677005151 putative CheW interface [polypeptide binding]; other site 932677005152 methyl-accepting protein IV; Provisional; Region: PRK09793 932677005153 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 932677005154 dimer interface [polypeptide binding]; other site 932677005155 ligand binding site [chemical binding]; other site 932677005156 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932677005157 dimerization interface [polypeptide binding]; other site 932677005158 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677005159 dimer interface [polypeptide binding]; other site 932677005160 putative CheW interface [polypeptide binding]; other site 932677005161 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 932677005162 putative CheA interaction surface; other site 932677005163 chemotaxis protein CheA; Provisional; Region: PRK10547 932677005164 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 932677005165 putative binding surface; other site 932677005166 active site 932677005167 CheY binding; Region: CheY-binding; pfam09078 932677005168 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 932677005169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677005170 ATP binding site [chemical binding]; other site 932677005171 Mg2+ binding site [ion binding]; other site 932677005172 G-X-G motif; other site 932677005173 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 932677005174 flagellar motor protein MotB; Validated; Region: motB; PRK09041 932677005175 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 932677005176 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 932677005177 ligand binding site [chemical binding]; other site 932677005178 flagellar motor protein MotA; Validated; Region: PRK09110 932677005179 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 932677005180 transcriptional activator FlhC; Provisional; Region: PRK12722 932677005181 transcriptional activator FlhD; Provisional; Region: PRK02909 932677005182 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 932677005183 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 932677005184 active site 932677005185 homotetramer interface [polypeptide binding]; other site 932677005186 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 932677005187 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 932677005188 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 932677005189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677005190 active site 932677005191 phosphorylation site [posttranslational modification] 932677005192 intermolecular recognition site; other site 932677005193 dimerization interface [polypeptide binding]; other site 932677005194 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932677005195 DNA binding site [nucleotide binding] 932677005196 sensor protein BasS/PmrB; Provisional; Region: PRK10755 932677005197 HAMP domain; Region: HAMP; pfam00672 932677005198 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932677005199 dimer interface [polypeptide binding]; other site 932677005200 phosphorylation site [posttranslational modification] 932677005201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677005202 ATP binding site [chemical binding]; other site 932677005203 Mg2+ binding site [ion binding]; other site 932677005204 G-X-G motif; other site 932677005205 methionine sulfoxide reductase A; Provisional; Region: PRK14054 932677005206 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 932677005207 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677005208 substrate binding pocket [chemical binding]; other site 932677005209 membrane-bound complex binding site; other site 932677005210 hinge residues; other site 932677005211 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 932677005212 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677005213 Walker A motif; other site 932677005214 ATP binding site [chemical binding]; other site 932677005215 Walker B motif; other site 932677005216 arginine finger; other site 932677005217 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 932677005218 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 932677005219 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677005220 substrate binding pocket [chemical binding]; other site 932677005221 membrane-bound complex binding site; other site 932677005222 hinge residues; other site 932677005223 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 932677005224 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 932677005225 active site 932677005226 dimer interface [polypeptide binding]; other site 932677005227 non-prolyl cis peptide bond; other site 932677005228 insertion regions; other site 932677005229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 932677005230 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 932677005231 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 932677005232 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 932677005233 non-prolyl cis peptide bond; other site 932677005234 active site 932677005235 potential protein location (hypothetical protein) that overlaps protein (dibenzothiophene desulfurization enzyme A SoxA) 932677005236 benzoate transport; Region: 2A0115; TIGR00895 932677005237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677005238 putative substrate translocation pore; other site 932677005239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677005240 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 932677005241 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 932677005242 Flavin binding site [chemical binding]; other site 932677005243 hypothetical protein; Provisional; Region: PRK10536 932677005244 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 932677005245 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 932677005246 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 932677005247 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 932677005248 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 932677005249 Imelysin; Region: Peptidase_M75; pfam09375 932677005250 Iron permease FTR1 family; Region: FTR1; cl00475 932677005251 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 932677005252 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 932677005253 Na binding site [ion binding]; other site 932677005254 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 932677005255 Predicted transcriptional regulator [Transcription]; Region: COG3905 932677005256 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 932677005257 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 932677005258 Glutamate binding site [chemical binding]; other site 932677005259 NAD binding site [chemical binding]; other site 932677005260 catalytic residues [active] 932677005261 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 932677005262 Predicted membrane protein [Function unknown]; Region: COG4763 932677005263 Acyltransferase family; Region: Acyl_transf_3; pfam01757 932677005264 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 932677005265 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 932677005266 dimer interface [polypeptide binding]; other site 932677005267 ADP-ribose binding site [chemical binding]; other site 932677005268 active site 932677005269 nudix motif; other site 932677005270 metal binding site [ion binding]; metal-binding site 932677005271 Predicted membrane protein [Function unknown]; Region: COG4763 932677005272 Acyltransferase family; Region: Acyl_transf_3; pfam01757 932677005273 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 932677005274 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 932677005275 Walker A/P-loop; other site 932677005276 ATP binding site [chemical binding]; other site 932677005277 Q-loop/lid; other site 932677005278 ABC transporter signature motif; other site 932677005279 Walker B; other site 932677005280 D-loop; other site 932677005281 H-loop/switch region; other site 932677005282 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 932677005283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677005284 dimer interface [polypeptide binding]; other site 932677005285 conserved gate region; other site 932677005286 putative PBP binding loops; other site 932677005287 ABC-ATPase subunit interface; other site 932677005288 cystine transporter subunit; Provisional; Region: PRK11260 932677005289 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677005290 substrate binding pocket [chemical binding]; other site 932677005291 membrane-bound complex binding site; other site 932677005292 hinge residues; other site 932677005293 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 932677005294 D-cysteine desulfhydrase; Validated; Region: PRK03910 932677005295 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932677005296 catalytic residue [active] 932677005297 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 932677005298 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 932677005299 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 932677005300 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 932677005301 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 932677005302 DNA binding residues [nucleotide binding] 932677005303 HNH endonuclease; Region: HNH_2; pfam13391 932677005304 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 932677005305 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 932677005306 substrate binding site; other site 932677005307 tetramer interface; other site 932677005308 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 932677005309 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 932677005310 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 932677005311 NADP binding site [chemical binding]; other site 932677005312 active site 932677005313 putative substrate binding site [chemical binding]; other site 932677005314 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 932677005315 NAD(P) binding site [chemical binding]; other site 932677005316 catalytic residues [active] 932677005317 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 932677005318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 932677005319 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 932677005320 acyl-activating enzyme (AAE) consensus motif; other site 932677005321 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 932677005322 AMP binding site [chemical binding]; other site 932677005323 active site 932677005324 acyl-activating enzyme (AAE) consensus motif; other site 932677005325 CoA binding site [chemical binding]; other site 932677005326 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 932677005327 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 932677005328 PYR/PP interface [polypeptide binding]; other site 932677005329 dimer interface [polypeptide binding]; other site 932677005330 TPP binding site [chemical binding]; other site 932677005331 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 932677005332 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 932677005333 TPP-binding site [chemical binding]; other site 932677005334 dimer interface [polypeptide binding]; other site 932677005335 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 932677005336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932677005337 NAD(P) binding site [chemical binding]; other site 932677005338 active site 932677005339 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 932677005340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932677005341 NAD(P) binding site [chemical binding]; other site 932677005342 active site 932677005343 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 932677005344 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 932677005345 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 932677005346 putative trimer interface [polypeptide binding]; other site 932677005347 putative CoA binding site [chemical binding]; other site 932677005348 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 932677005349 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 932677005350 inhibitor-cofactor binding pocket; inhibition site 932677005351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677005352 catalytic residue [active] 932677005353 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 932677005354 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 932677005355 active site 932677005356 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 932677005357 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 932677005358 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 932677005359 Probable Catalytic site; other site 932677005360 metal-binding site 932677005361 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 932677005362 flagellin; Provisional; Region: PRK12802 932677005363 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 932677005364 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 932677005365 flagellin; Reviewed; Region: PRK08869 932677005366 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 932677005367 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 932677005368 flagellin; Reviewed; Region: PRK08869 932677005369 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 932677005370 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 932677005371 flagellin; Provisional; Region: PRK12802 932677005372 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 932677005373 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 932677005374 flagellar capping protein; Reviewed; Region: fliD; PRK08032 932677005375 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 932677005376 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 932677005377 flagellar protein FliS; Validated; Region: fliS; PRK05685 932677005378 Flagellar protein FliT; Region: FliT; cl05125 932677005379 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 932677005380 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 932677005381 active site 932677005382 Na/Ca binding site [ion binding]; other site 932677005383 catalytic site [active] 932677005384 lipoprotein; Provisional; Region: PRK10397 932677005385 anti-RssB factor; Provisional; Region: PRK10244 932677005386 DinI-like family; Region: DinI; cl11630 932677005387 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 932677005388 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 932677005389 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 932677005390 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 932677005391 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 932677005392 FliG C-terminal domain; Region: FliG_C; pfam01706 932677005393 flagellar assembly protein H; Validated; Region: fliH; PRK05687 932677005394 Flagellar assembly protein FliH; Region: FliH; pfam02108 932677005395 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 932677005396 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 932677005397 Walker A motif/ATP binding site; other site 932677005398 Walker B motif; other site 932677005399 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 932677005400 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 932677005401 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 932677005402 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 932677005403 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 932677005404 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 932677005405 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 932677005406 flagellar motor switch protein; Validated; Region: fliN; PRK05698 932677005407 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 932677005408 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 932677005409 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 932677005410 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 932677005411 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 932677005412 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 932677005413 DNA binding residues [nucleotide binding] 932677005414 dimerization interface [polypeptide binding]; other site 932677005415 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 932677005416 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 932677005417 dimer interface [polypeptide binding]; other site 932677005418 ligand binding site [chemical binding]; other site 932677005419 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932677005420 dimerization interface [polypeptide binding]; other site 932677005421 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677005422 dimer interface [polypeptide binding]; other site 932677005423 putative CheW interface [polypeptide binding]; other site 932677005424 hypothetical protein; Provisional; Region: PRK10708 932677005425 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 932677005426 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677005427 active site 932677005428 motif I; other site 932677005429 motif II; other site 932677005430 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 932677005431 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 932677005432 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 932677005433 hypothetical protein; Provisional; Region: PRK10062 932677005434 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 932677005435 additional DNA contacts [nucleotide binding]; other site 932677005436 mismatch recognition site; other site 932677005437 active site 932677005438 zinc binding site [ion binding]; other site 932677005439 DNA intercalation site [nucleotide binding]; other site 932677005440 DNA cytosine methylase; Provisional; Region: PRK10458 932677005441 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 932677005442 cofactor binding site; other site 932677005443 DNA binding site [nucleotide binding] 932677005444 substrate interaction site [chemical binding]; other site 932677005445 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 932677005446 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 932677005447 dimer interface [polypeptide binding]; other site 932677005448 ligand binding site [chemical binding]; other site 932677005449 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677005450 dimer interface [polypeptide binding]; other site 932677005451 putative CheW interface [polypeptide binding]; other site 932677005452 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 932677005453 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932677005454 Zn2+ binding site [ion binding]; other site 932677005455 Mg2+ binding site [ion binding]; other site 932677005456 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 932677005457 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 932677005458 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 932677005459 ferrochelatase; Reviewed; Region: hemH; PRK00035 932677005460 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 932677005461 C-terminal domain interface [polypeptide binding]; other site 932677005462 active site 932677005463 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 932677005464 active site 932677005465 N-terminal domain interface [polypeptide binding]; other site 932677005466 H+ Antiporter protein; Region: 2A0121; TIGR00900 932677005467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677005468 putative substrate translocation pore; other site 932677005469 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 932677005470 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932677005471 ABC-ATPase subunit interface; other site 932677005472 dimer interface [polypeptide binding]; other site 932677005473 putative PBP binding regions; other site 932677005474 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 932677005475 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 932677005476 putative ligand binding residues [chemical binding]; other site 932677005477 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 932677005478 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677005479 Walker A/P-loop; other site 932677005480 ATP binding site [chemical binding]; other site 932677005481 Q-loop/lid; other site 932677005482 ABC transporter signature motif; other site 932677005483 Walker B; other site 932677005484 D-loop; other site 932677005485 H-loop/switch region; other site 932677005486 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 932677005487 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 932677005488 putative dimer interface [polypeptide binding]; other site 932677005489 HTH domain; Region: HTH_11; pfam08279 932677005490 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932677005491 PRD domain; Region: PRD; pfam00874 932677005492 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932677005493 active site 932677005494 P-loop; other site 932677005495 phosphorylation site [posttranslational modification] 932677005496 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932677005497 active site 932677005498 phosphorylation site [posttranslational modification] 932677005499 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 932677005500 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 932677005501 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 932677005502 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 932677005503 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 932677005504 active site 932677005505 P-loop; other site 932677005506 phosphorylation site [posttranslational modification] 932677005507 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932677005508 active site 932677005509 phosphorylation site [posttranslational modification] 932677005510 PAAR motif; Region: PAAR_motif; pfam05488 932677005511 RHS Repeat; Region: RHS_repeat; pfam05593 932677005512 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 932677005513 RHS Repeat; Region: RHS_repeat; pfam05593 932677005514 RHS Repeat; Region: RHS_repeat; pfam05593 932677005515 RHS protein; Region: RHS; pfam03527 932677005516 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 932677005517 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 932677005518 potential frameshift: common BLAST hit: gi|378766716|ref|YP_005195179.1| ImpA family type VI secretion-associated protein 932677005519 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 932677005520 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 932677005521 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 932677005522 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 932677005523 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 932677005524 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 932677005525 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 932677005526 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 932677005527 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 932677005528 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 932677005529 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 932677005530 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 932677005531 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 932677005532 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 932677005533 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 932677005534 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 932677005535 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 932677005536 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 932677005537 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 932677005538 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 932677005539 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 932677005540 Catalytic domain of Protein Kinases; Region: PKc; cd00180 932677005541 active site 932677005542 ATP binding site [chemical binding]; other site 932677005543 substrate binding site [chemical binding]; other site 932677005544 activation loop (A-loop); other site 932677005545 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 932677005546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677005547 Walker A motif; other site 932677005548 ATP binding site [chemical binding]; other site 932677005549 Walker B motif; other site 932677005550 arginine finger; other site 932677005551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677005552 Walker A motif; other site 932677005553 ATP binding site [chemical binding]; other site 932677005554 Walker B motif; other site 932677005555 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 932677005556 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 932677005557 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 932677005558 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 932677005559 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 932677005560 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 932677005561 ImpE protein; Region: ImpE; pfam07024 932677005562 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 932677005563 active site 932677005564 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 932677005565 phosphopeptide binding site; other site 932677005566 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 932677005567 Protein of unknown function (DUF796); Region: DUF796; pfam05638 932677005568 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 932677005569 Protein of unknown function (DUF877); Region: DUF877; pfam05943 932677005570 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 932677005571 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 932677005572 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 932677005573 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 932677005574 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 932677005575 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 932677005576 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 932677005577 hypothetical protein; Provisional; Region: PRK07033 932677005578 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 932677005579 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 932677005580 ligand binding site [chemical binding]; other site 932677005581 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 932677005582 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 932677005583 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 932677005584 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 932677005585 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 932677005586 AMP nucleosidase; Provisional; Region: PRK08292 932677005587 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 932677005588 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 932677005589 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 932677005590 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932677005591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677005592 active site 932677005593 phosphorylation site [posttranslational modification] 932677005594 intermolecular recognition site; other site 932677005595 dimerization interface [polypeptide binding]; other site 932677005596 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932677005597 DNA binding site [nucleotide binding] 932677005598 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 932677005599 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 932677005600 substrate binding site [chemical binding]; other site 932677005601 ATP binding site [chemical binding]; other site 932677005602 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 932677005603 intersubunit interface [polypeptide binding]; other site 932677005604 active site 932677005605 zinc binding site [ion binding]; other site 932677005606 Na+ binding site [ion binding]; other site 932677005607 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 932677005608 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 932677005609 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 932677005610 putative ligand binding site [chemical binding]; other site 932677005611 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932677005612 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 932677005613 TM-ABC transporter signature motif; other site 932677005614 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 932677005615 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 932677005616 Walker A/P-loop; other site 932677005617 ATP binding site [chemical binding]; other site 932677005618 Q-loop/lid; other site 932677005619 ABC transporter signature motif; other site 932677005620 Walker B; other site 932677005621 D-loop; other site 932677005622 H-loop/switch region; other site 932677005623 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 932677005624 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 932677005625 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932677005626 dimerization interface [polypeptide binding]; other site 932677005627 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 932677005628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677005629 ATP binding site [chemical binding]; other site 932677005630 Mg2+ binding site [ion binding]; other site 932677005631 G-X-G motif; other site 932677005632 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 932677005633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677005634 active site 932677005635 phosphorylation site [posttranslational modification] 932677005636 intermolecular recognition site; other site 932677005637 dimerization interface [polypeptide binding]; other site 932677005638 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 932677005639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677005640 dimer interface [polypeptide binding]; other site 932677005641 conserved gate region; other site 932677005642 ABC-ATPase subunit interface; other site 932677005643 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 932677005644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677005645 dimer interface [polypeptide binding]; other site 932677005646 conserved gate region; other site 932677005647 putative PBP binding loops; other site 932677005648 ABC-ATPase subunit interface; other site 932677005649 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 932677005650 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 932677005651 substrate binding pocket [chemical binding]; other site 932677005652 membrane-bound complex binding site; other site 932677005653 hinge residues; other site 932677005654 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 932677005655 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 932677005656 Walker A/P-loop; other site 932677005657 ATP binding site [chemical binding]; other site 932677005658 Q-loop/lid; other site 932677005659 ABC transporter signature motif; other site 932677005660 Walker B; other site 932677005661 D-loop; other site 932677005662 H-loop/switch region; other site 932677005663 putative hydrolase; Provisional; Region: PRK02113 932677005664 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 932677005665 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 932677005666 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 932677005667 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 932677005668 active site 932677005669 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 932677005670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677005671 Walker A/P-loop; other site 932677005672 ATP binding site [chemical binding]; other site 932677005673 Q-loop/lid; other site 932677005674 ABC transporter signature motif; other site 932677005675 Walker B; other site 932677005676 D-loop; other site 932677005677 H-loop/switch region; other site 932677005678 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 932677005679 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932677005680 Walker A/P-loop; other site 932677005681 ATP binding site [chemical binding]; other site 932677005682 Q-loop/lid; other site 932677005683 ABC transporter signature motif; other site 932677005684 Walker B; other site 932677005685 D-loop; other site 932677005686 H-loop/switch region; other site 932677005687 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 932677005688 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 932677005689 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 932677005690 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 932677005691 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 932677005692 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932677005693 DNA-binding site [nucleotide binding]; DNA binding site 932677005694 UTRA domain; Region: UTRA; pfam07702 932677005695 Isochorismatase family; Region: Isochorismatase; pfam00857 932677005696 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 932677005697 catalytic triad [active] 932677005698 conserved cis-peptide bond; other site 932677005699 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 932677005700 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 932677005701 Na binding site [ion binding]; other site 932677005702 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 932677005703 active site 932677005704 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 932677005705 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 932677005706 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 932677005707 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932677005708 putative DNA binding site [nucleotide binding]; other site 932677005709 putative Zn2+ binding site [ion binding]; other site 932677005710 AsnC family; Region: AsnC_trans_reg; pfam01037 932677005711 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 932677005712 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 932677005713 inhibitor-cofactor binding pocket; inhibition site 932677005714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677005715 catalytic residue [active] 932677005716 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 932677005717 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 932677005718 metal binding site [ion binding]; metal-binding site 932677005719 putative dimer interface [polypeptide binding]; other site 932677005720 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 932677005721 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 932677005722 putative ligand binding site [chemical binding]; other site 932677005723 NAD binding site [chemical binding]; other site 932677005724 dimerization interface [polypeptide binding]; other site 932677005725 catalytic site [active] 932677005726 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 932677005727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677005728 Coenzyme A binding pocket [chemical binding]; other site 932677005729 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 932677005730 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 932677005731 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 932677005732 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932677005733 Walker A/P-loop; other site 932677005734 ATP binding site [chemical binding]; other site 932677005735 Q-loop/lid; other site 932677005736 ABC transporter signature motif; other site 932677005737 Walker B; other site 932677005738 D-loop; other site 932677005739 H-loop/switch region; other site 932677005740 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932677005741 Walker A/P-loop; other site 932677005742 ATP binding site [chemical binding]; other site 932677005743 Q-loop/lid; other site 932677005744 ABC transporter signature motif; other site 932677005745 Walker B; other site 932677005746 D-loop; other site 932677005747 H-loop/switch region; other site 932677005748 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 932677005749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677005750 dimer interface [polypeptide binding]; other site 932677005751 conserved gate region; other site 932677005752 ABC-ATPase subunit interface; other site 932677005753 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 932677005754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677005755 dimer interface [polypeptide binding]; other site 932677005756 conserved gate region; other site 932677005757 putative PBP binding loops; other site 932677005758 ABC-ATPase subunit interface; other site 932677005759 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 932677005760 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 932677005761 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 932677005762 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 932677005763 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 932677005764 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677005765 motif II; other site 932677005766 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 932677005767 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 932677005768 NAD(P) binding site [chemical binding]; other site 932677005769 catalytic residues [active] 932677005770 succinic semialdehyde dehydrogenase; Region: PLN02278 932677005771 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 932677005772 tetramerization interface [polypeptide binding]; other site 932677005773 NAD(P) binding site [chemical binding]; other site 932677005774 catalytic residues [active] 932677005775 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 932677005776 substrate binding site [chemical binding]; other site 932677005777 dimerization interface [polypeptide binding]; other site 932677005778 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 932677005779 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677005780 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 932677005781 putative dimerization interface [polypeptide binding]; other site 932677005782 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 932677005783 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932677005784 TM-ABC transporter signature motif; other site 932677005785 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 932677005786 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 932677005787 Walker A/P-loop; other site 932677005788 ATP binding site [chemical binding]; other site 932677005789 Q-loop/lid; other site 932677005790 ABC transporter signature motif; other site 932677005791 Walker B; other site 932677005792 D-loop; other site 932677005793 H-loop/switch region; other site 932677005794 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 932677005795 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 932677005796 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 932677005797 putative ligand binding site [chemical binding]; other site 932677005798 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 932677005799 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677005800 dimer interface [polypeptide binding]; other site 932677005801 putative CheW interface [polypeptide binding]; other site 932677005802 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 932677005803 catalytic loop [active] 932677005804 iron binding site [ion binding]; other site 932677005805 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 932677005806 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 932677005807 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 932677005808 active site 932677005809 substrate binding site [chemical binding]; other site 932677005810 Mg2+ binding site [ion binding]; other site 932677005811 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 932677005812 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932677005813 putative DNA binding site [nucleotide binding]; other site 932677005814 putative Zn2+ binding site [ion binding]; other site 932677005815 AsnC family; Region: AsnC_trans_reg; pfam01037 932677005816 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 932677005817 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 932677005818 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932677005819 FAD binding domain; Region: FAD_binding_4; pfam01565 932677005820 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 932677005821 Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537 932677005822 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 932677005823 substrate binding site; other site 932677005824 Manganese binding site; other site 932677005825 dimer interface; other site 932677005826 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 932677005827 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932677005828 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 932677005829 Domain of unknown function (DUF718); Region: DUF718; cl01281 932677005830 rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634 932677005831 intersubunit interface [polypeptide binding]; other site 932677005832 active site 932677005833 Zn2+ binding site [ion binding]; other site 932677005834 L-rhamnose isomerase; Provisional; Region: PRK01076 932677005835 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 932677005836 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 932677005837 N- and C-terminal domain interface [polypeptide binding]; other site 932677005838 active site 932677005839 putative catalytic site [active] 932677005840 metal binding site [ion binding]; metal-binding site 932677005841 ATP binding site [chemical binding]; other site 932677005842 rhamnulokinase; Provisional; Region: rhaB; PRK10640 932677005843 carbohydrate binding site [chemical binding]; other site 932677005844 transcriptional activator RhaS; Provisional; Region: PRK13503 932677005845 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 932677005846 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677005847 transcriptional activator RhaR; Provisional; Region: PRK13501 932677005848 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 932677005849 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677005850 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 932677005851 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 932677005852 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 932677005853 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 932677005854 NAD binding site [chemical binding]; other site 932677005855 catalytic residues [active] 932677005856 substrate binding site [chemical binding]; other site 932677005857 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 932677005858 Protein of unknown function (DUF796); Region: DUF796; pfam05638 932677005859 Protein of unknown function (DUF796); Region: DUF796; pfam05638 932677005860 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 932677005861 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 932677005862 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 932677005863 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 932677005864 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 932677005865 lac repressor; Reviewed; Region: lacI; PRK09526 932677005866 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932677005867 DNA binding site [nucleotide binding] 932677005868 domain linker motif; other site 932677005869 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 932677005870 ligand binding site [chemical binding]; other site 932677005871 dimerization interface (open form) [polypeptide binding]; other site 932677005872 dimerization interface (closed form) [polypeptide binding]; other site 932677005873 hypothetical protein; Provisional; Region: PRK05423 932677005874 Predicted membrane protein [Function unknown]; Region: COG1289 932677005875 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 932677005876 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 932677005877 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 932677005878 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 932677005879 exonuclease I; Provisional; Region: sbcB; PRK11779 932677005880 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 932677005881 active site 932677005882 substrate binding site [chemical binding]; other site 932677005883 catalytic site [active] 932677005884 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 932677005885 putative transporter; Provisional; Region: PRK09821 932677005886 GntP family permease; Region: GntP_permease; pfam02447 932677005887 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 932677005888 putative aldolase; Validated; Region: PRK08130 932677005889 intersubunit interface [polypeptide binding]; other site 932677005890 active site 932677005891 Zn2+ binding site [ion binding]; other site 932677005892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 932677005893 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 932677005894 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 932677005895 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 932677005896 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 932677005897 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 932677005898 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 932677005899 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 932677005900 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 932677005901 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 932677005902 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 932677005903 catalytic triad [active] 932677005904 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932677005905 non-specific DNA binding site [nucleotide binding]; other site 932677005906 salt bridge; other site 932677005907 sequence-specific DNA binding site [nucleotide binding]; other site 932677005908 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 932677005909 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 932677005910 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 932677005911 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 932677005912 putative NAD(P) binding site [chemical binding]; other site 932677005913 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 932677005914 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 932677005915 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 932677005916 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 932677005917 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 932677005918 NAD binding site [chemical binding]; other site 932677005919 dimerization interface [polypeptide binding]; other site 932677005920 product binding site; other site 932677005921 substrate binding site [chemical binding]; other site 932677005922 zinc binding site [ion binding]; other site 932677005923 catalytic residues [active] 932677005924 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 932677005925 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932677005926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677005927 homodimer interface [polypeptide binding]; other site 932677005928 catalytic residue [active] 932677005929 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 932677005930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677005931 active site 932677005932 motif I; other site 932677005933 motif II; other site 932677005934 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 932677005935 putative active site pocket [active] 932677005936 4-fold oligomerization interface [polypeptide binding]; other site 932677005937 metal binding residues [ion binding]; metal-binding site 932677005938 3-fold/trimer interface [polypeptide binding]; other site 932677005939 potential protein location (hypothetical protein) that overlaps protein (histidine biosynthesis bifunctional protein HisB) 932677005940 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 932677005941 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 932677005942 putative active site [active] 932677005943 oxyanion strand; other site 932677005944 catalytic triad [active] 932677005945 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 932677005946 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 932677005947 catalytic residues [active] 932677005948 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 932677005949 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 932677005950 substrate binding site [chemical binding]; other site 932677005951 glutamase interaction surface [polypeptide binding]; other site 932677005952 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 932677005953 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 932677005954 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 932677005955 metal binding site [ion binding]; metal-binding site 932677005956 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 932677005957 HipA-like N-terminal domain; Region: HipA_N; pfam07805 932677005958 HipA-like C-terminal domain; Region: HipA_C; pfam07804 932677005959 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932677005960 non-specific DNA binding site [nucleotide binding]; other site 932677005961 salt bridge; other site 932677005962 sequence-specific DNA binding site [nucleotide binding]; other site 932677005963 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 932677005964 putative deacylase active site [active] 932677005965 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 932677005966 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677005967 substrate binding pocket [chemical binding]; other site 932677005968 membrane-bound complex binding site; other site 932677005969 hinge residues; other site 932677005970 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 932677005971 active site 932677005972 Zn binding site [ion binding]; other site 932677005973 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 932677005974 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 932677005975 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 932677005976 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 932677005977 DNA polymerase III PolC; Validated; Region: polC; PRK00448 932677005978 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 932677005979 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 932677005980 Ligand binding site; other site 932677005981 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 932677005982 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 932677005983 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 932677005984 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 932677005985 Walker A/P-loop; other site 932677005986 ATP binding site [chemical binding]; other site 932677005987 Q-loop/lid; other site 932677005988 ABC transporter signature motif; other site 932677005989 Walker B; other site 932677005990 D-loop; other site 932677005991 H-loop/switch region; other site 932677005992 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 932677005993 active site 932677005994 WavE lipopolysaccharide synthesis; Region: WavE; pfam07507 932677005995 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 932677005996 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 932677005997 NAD binding site [chemical binding]; other site 932677005998 homodimer interface [polypeptide binding]; other site 932677005999 active site 932677006000 substrate binding site [chemical binding]; other site 932677006001 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 932677006002 active site 932677006003 tetramer interface; other site 932677006004 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 932677006005 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 932677006006 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 932677006007 putative ADP-binding pocket [chemical binding]; other site 932677006008 colanic acid biosynthesis protein; Provisional; Region: PRK10017 932677006009 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 932677006010 Head binding; Region: Head_binding; pfam09008 932677006011 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 932677006012 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 932677006013 putative ADP-binding pocket [chemical binding]; other site 932677006014 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 932677006015 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 932677006016 active site 932677006017 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 932677006018 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 932677006019 active site 932677006020 tyrosine kinase; Provisional; Region: PRK11519 932677006021 Chain length determinant protein; Region: Wzz; pfam02706 932677006022 Chain length determinant protein; Region: Wzz; cl15801 932677006023 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 932677006024 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 932677006025 Low molecular weight phosphatase family; Region: LMWPc; cd00115 932677006026 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 932677006027 active site 932677006028 polysaccharide export protein Wza; Provisional; Region: PRK15078 932677006029 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 932677006030 SLBB domain; Region: SLBB; pfam10531 932677006031 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 932677006032 Bacterial sugar transferase; Region: Bac_transf; pfam02397 932677006033 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 932677006034 FOG: CBS domain [General function prediction only]; Region: COG0517 932677006035 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 932677006036 Transporter associated domain; Region: CorC_HlyC; smart01091 932677006037 putative assembly protein; Provisional; Region: PRK10833 932677006038 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 932677006039 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 932677006040 trimer interface [polypeptide binding]; other site 932677006041 active site 932677006042 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 932677006043 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 932677006044 ATP-binding site [chemical binding]; other site 932677006045 Sugar specificity; other site 932677006046 Pyrimidine base specificity; other site 932677006047 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 932677006048 active site 932677006049 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 932677006050 MASE1; Region: MASE1; cl17823 932677006051 PAS domain S-box; Region: sensory_box; TIGR00229 932677006052 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932677006053 putative active site [active] 932677006054 heme pocket [chemical binding]; other site 932677006055 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 932677006056 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932677006057 putative active site [active] 932677006058 heme pocket [chemical binding]; other site 932677006059 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932677006060 putative active site [active] 932677006061 heme pocket [chemical binding]; other site 932677006062 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932677006063 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932677006064 metal binding site [ion binding]; metal-binding site 932677006065 active site 932677006066 I-site; other site 932677006067 putative chaperone; Provisional; Region: PRK11678 932677006068 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 932677006069 nucleotide binding site [chemical binding]; other site 932677006070 putative NEF/HSP70 interaction site [polypeptide binding]; other site 932677006071 SBD interface [polypeptide binding]; other site 932677006072 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 932677006073 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 932677006074 HlyD family secretion protein; Region: HlyD_3; pfam13437 932677006075 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 932677006076 Protein export membrane protein; Region: SecD_SecF; cl14618 932677006077 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 932677006078 Protein export membrane protein; Region: SecD_SecF; cl14618 932677006079 putative transporter; Provisional; Region: PRK10504 932677006080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677006081 putative substrate translocation pore; other site 932677006082 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 932677006083 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932677006084 dimerization interface [polypeptide binding]; other site 932677006085 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932677006086 dimer interface [polypeptide binding]; other site 932677006087 phosphorylation site [posttranslational modification] 932677006088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677006089 ATP binding site [chemical binding]; other site 932677006090 Mg2+ binding site [ion binding]; other site 932677006091 G-X-G motif; other site 932677006092 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 932677006093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677006094 active site 932677006095 phosphorylation site [posttranslational modification] 932677006096 intermolecular recognition site; other site 932677006097 dimerization interface [polypeptide binding]; other site 932677006098 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932677006099 DNA binding site [nucleotide binding] 932677006100 putative protease; Provisional; Region: PRK15452 932677006101 Peptidase family U32; Region: Peptidase_U32; pfam01136 932677006102 lipid kinase; Reviewed; Region: PRK13054 932677006103 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 932677006104 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 932677006105 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 932677006106 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 932677006107 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932677006108 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 932677006109 DNA-binding site [nucleotide binding]; DNA binding site 932677006110 FCD domain; Region: FCD; pfam07729 932677006111 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 932677006112 dimer interface [polypeptide binding]; other site 932677006113 substrate binding site [chemical binding]; other site 932677006114 ATP binding site [chemical binding]; other site 932677006115 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 932677006116 substrate binding site [chemical binding]; other site 932677006117 multimerization interface [polypeptide binding]; other site 932677006118 ATP binding site [chemical binding]; other site 932677006119 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 932677006120 Predicted permeases [General function prediction only]; Region: COG0679 932677006121 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 932677006122 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 932677006123 catalytic residue [active] 932677006124 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 932677006125 catalytic residues [active] 932677006126 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932677006127 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932677006128 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 932677006129 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 932677006130 dimer interface [polypeptide binding]; other site 932677006131 decamer (pentamer of dimers) interface [polypeptide binding]; other site 932677006132 catalytic triad [active] 932677006133 peroxidatic and resolving cysteines [active] 932677006134 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 932677006135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677006136 Coenzyme A binding pocket [chemical binding]; other site 932677006137 antiporter inner membrane protein; Provisional; Region: PRK11670 932677006138 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 932677006139 Walker A motif; other site 932677006140 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 932677006141 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 932677006142 active site 932677006143 HIGH motif; other site 932677006144 KMSKS motif; other site 932677006145 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 932677006146 tRNA binding surface [nucleotide binding]; other site 932677006147 anticodon binding site; other site 932677006148 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 932677006149 dimer interface [polypeptide binding]; other site 932677006150 putative tRNA-binding site [nucleotide binding]; other site 932677006151 hypothetical protein; Provisional; Region: PRK01821 932677006152 hypothetical protein; Provisional; Region: PRK10711 932677006153 cytidine deaminase; Provisional; Region: PRK09027 932677006154 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 932677006155 active site 932677006156 catalytic motif [active] 932677006157 Zn binding site [ion binding]; other site 932677006158 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 932677006159 active site 932677006160 catalytic motif [active] 932677006161 Zn binding site [ion binding]; other site 932677006162 malate dehydrogenase; Provisional; Region: PRK13529 932677006163 Malic enzyme, N-terminal domain; Region: malic; pfam00390 932677006164 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 932677006165 NAD(P) binding site [chemical binding]; other site 932677006166 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 932677006167 putative active site [active] 932677006168 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932677006169 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 932677006170 TM-ABC transporter signature motif; other site 932677006171 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 932677006172 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 932677006173 Walker A/P-loop; other site 932677006174 ATP binding site [chemical binding]; other site 932677006175 Q-loop/lid; other site 932677006176 ABC transporter signature motif; other site 932677006177 Walker B; other site 932677006178 D-loop; other site 932677006179 H-loop/switch region; other site 932677006180 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 932677006181 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 932677006182 ligand binding site [chemical binding]; other site 932677006183 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 932677006184 calcium binding site [ion binding]; other site 932677006185 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 932677006186 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932677006187 DNA binding site [nucleotide binding] 932677006188 domain linker motif; other site 932677006189 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 932677006190 dimerization interface (closed form) [polypeptide binding]; other site 932677006191 ligand binding site [chemical binding]; other site 932677006192 Predicted membrane protein [Function unknown]; Region: COG2311 932677006193 hypothetical protein; Provisional; Region: PRK10835 932677006194 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 932677006195 GTP cyclohydrolase I; Provisional; Region: PLN03044 932677006196 active site 932677006197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677006198 putative substrate translocation pore; other site 932677006199 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677006200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677006201 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 932677006202 putative dimerization interface [polypeptide binding]; other site 932677006203 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 932677006204 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 932677006205 substrate binding site [chemical binding]; other site 932677006206 catalytic Zn binding site [ion binding]; other site 932677006207 NAD binding site [chemical binding]; other site 932677006208 structural Zn binding site [ion binding]; other site 932677006209 dimer interface [polypeptide binding]; other site 932677006210 S-formylglutathione hydrolase; Region: PLN02442 932677006211 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 932677006212 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 932677006213 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 932677006214 Walker A/P-loop; other site 932677006215 ATP binding site [chemical binding]; other site 932677006216 Q-loop/lid; other site 932677006217 ABC transporter signature motif; other site 932677006218 Walker B; other site 932677006219 D-loop; other site 932677006220 H-loop/switch region; other site 932677006221 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 932677006222 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932677006223 ABC-ATPase subunit interface; other site 932677006224 dimer interface [polypeptide binding]; other site 932677006225 putative PBP binding regions; other site 932677006226 lysine transporter; Provisional; Region: PRK10836 932677006227 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 932677006228 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677006229 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 932677006230 putative dimerization interface [polypeptide binding]; other site 932677006231 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 932677006232 putative transposase; Provisional; Region: PRK09857 932677006233 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 932677006234 endonuclease IV; Provisional; Region: PRK01060 932677006235 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 932677006236 AP (apurinic/apyrimidinic) site pocket; other site 932677006237 DNA interaction; other site 932677006238 Metal-binding active site; metal-binding site 932677006239 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 932677006240 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 932677006241 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 932677006242 active site 932677006243 P-loop; other site 932677006244 phosphorylation site [posttranslational modification] 932677006245 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 932677006246 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 932677006247 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 932677006248 putative substrate binding site [chemical binding]; other site 932677006249 putative ATP binding site [chemical binding]; other site 932677006250 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 932677006251 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932677006252 active site 932677006253 phosphorylation site [posttranslational modification] 932677006254 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 932677006255 dimerization domain swap beta strand [polypeptide binding]; other site 932677006256 regulatory protein interface [polypeptide binding]; other site 932677006257 active site 932677006258 regulatory phosphorylation site [posttranslational modification]; other site 932677006259 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 932677006260 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 932677006261 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 932677006262 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 932677006263 inhibitor site; inhibition site 932677006264 active site 932677006265 dimer interface [polypeptide binding]; other site 932677006266 catalytic residue [active] 932677006267 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932677006268 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932677006269 DNA binding site [nucleotide binding] 932677006270 domain linker motif; other site 932677006271 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 932677006272 benzoate transport; Region: 2A0115; TIGR00895 932677006273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677006274 putative substrate translocation pore; other site 932677006275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677006276 Flagellin N-methylase; Region: FliB; cl00497 932677006277 elongation factor P; Provisional; Region: PRK04542 932677006278 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 932677006279 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 932677006280 RNA binding site [nucleotide binding]; other site 932677006281 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 932677006282 RNA binding site [nucleotide binding]; other site 932677006283 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 932677006284 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 932677006285 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 932677006286 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 932677006287 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 932677006288 active site 932677006289 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 932677006290 NlpC/P60 family; Region: NLPC_P60; pfam00877 932677006291 phage resistance protein; Provisional; Region: PRK10551 932677006292 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 932677006293 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932677006294 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 932677006295 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 932677006296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677006297 dimer interface [polypeptide binding]; other site 932677006298 conserved gate region; other site 932677006299 putative PBP binding loops; other site 932677006300 ABC-ATPase subunit interface; other site 932677006301 microcin C ABC transporter permease; Provisional; Region: PRK15021 932677006302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677006303 dimer interface [polypeptide binding]; other site 932677006304 conserved gate region; other site 932677006305 putative PBP binding loops; other site 932677006306 ABC-ATPase subunit interface; other site 932677006307 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 932677006308 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932677006309 Walker A/P-loop; other site 932677006310 ATP binding site [chemical binding]; other site 932677006311 Q-loop/lid; other site 932677006312 ABC transporter signature motif; other site 932677006313 Walker B; other site 932677006314 D-loop; other site 932677006315 H-loop/switch region; other site 932677006316 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932677006317 Walker A/P-loop; other site 932677006318 ATP binding site [chemical binding]; other site 932677006319 Q-loop/lid; other site 932677006320 ABC transporter signature motif; other site 932677006321 Walker B; other site 932677006322 D-loop; other site 932677006323 H-loop/switch region; other site 932677006324 YejG-like protein; Region: YejG; pfam13989 932677006325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677006326 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 932677006327 putative substrate translocation pore; other site 932677006328 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 932677006329 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932677006330 RNA binding surface [nucleotide binding]; other site 932677006331 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 932677006332 active site 932677006333 uracil binding [chemical binding]; other site 932677006334 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 932677006335 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932677006336 ATP binding site [chemical binding]; other site 932677006337 putative Mg++ binding site [ion binding]; other site 932677006338 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932677006339 nucleotide binding region [chemical binding]; other site 932677006340 ATP-binding site [chemical binding]; other site 932677006341 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 932677006342 5S rRNA interface [nucleotide binding]; other site 932677006343 CTC domain interface [polypeptide binding]; other site 932677006344 L16 interface [polypeptide binding]; other site 932677006345 Nucleoid-associated protein [General function prediction only]; Region: COG3081 932677006346 nucleoid-associated protein NdpA; Validated; Region: PRK00378 932677006347 hypothetical protein; Provisional; Region: PRK13689 932677006348 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 932677006349 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 932677006350 Sulfatase; Region: Sulfatase; cl17466 932677006351 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 932677006352 protease TldD; Provisional; Region: tldD; PRK10735 932677006353 peptidase PmbA; Provisional; Region: PRK11040 932677006354 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 932677006355 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 932677006356 catalytic residues [active] 932677006357 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 932677006358 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 932677006359 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 932677006360 Secretin and TonB N terminus short domain; Region: STN; smart00965 932677006361 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 932677006362 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 932677006363 N-terminal plug; other site 932677006364 ligand-binding site [chemical binding]; other site 932677006365 RNA polymerase sigma factor; Provisional; Region: PRK12525 932677006366 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 932677006367 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 932677006368 DNA binding residues [nucleotide binding] 932677006369 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 932677006370 FecR protein; Region: FecR; pfam04773 932677006371 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 932677006372 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 932677006373 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 932677006374 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 932677006375 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 932677006376 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 932677006377 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 932677006378 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 932677006379 MFS/sugar transport protein; Region: MFS_2; pfam13347 932677006380 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 932677006381 Mechanosensitive ion channel; Region: MS_channel; pfam00924 932677006382 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 932677006383 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932677006384 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 932677006385 Walker A/P-loop; other site 932677006386 ATP binding site [chemical binding]; other site 932677006387 Q-loop/lid; other site 932677006388 ABC transporter signature motif; other site 932677006389 Walker B; other site 932677006390 D-loop; other site 932677006391 H-loop/switch region; other site 932677006392 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 932677006393 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 932677006394 ApbE family; Region: ApbE; pfam02424 932677006395 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 932677006396 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 932677006397 trimer interface [polypeptide binding]; other site 932677006398 eyelet of channel; other site 932677006399 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 932677006400 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 932677006401 HlyD family secretion protein; Region: HlyD_3; pfam13437 932677006402 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 932677006403 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932677006404 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 932677006405 Walker A/P-loop; other site 932677006406 ATP binding site [chemical binding]; other site 932677006407 Q-loop/lid; other site 932677006408 ABC transporter signature motif; other site 932677006409 Walker B; other site 932677006410 D-loop; other site 932677006411 H-loop/switch region; other site 932677006412 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 932677006413 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 932677006414 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 932677006415 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 932677006416 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 932677006417 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 932677006418 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 932677006419 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 932677006420 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 932677006421 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 932677006422 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 932677006423 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 932677006424 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 932677006425 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 932677006426 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 932677006427 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 932677006428 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 932677006429 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 932677006430 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 932677006431 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 932677006432 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 932677006433 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 932677006434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677006435 ATP binding site [chemical binding]; other site 932677006436 Mg2+ binding site [ion binding]; other site 932677006437 G-X-G motif; other site 932677006438 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 932677006439 putative binding surface; other site 932677006440 active site 932677006441 transcriptional regulator RcsB; Provisional; Region: PRK10840 932677006442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677006443 active site 932677006444 phosphorylation site [posttranslational modification] 932677006445 intermolecular recognition site; other site 932677006446 dimerization interface [polypeptide binding]; other site 932677006447 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 932677006448 DNA binding residues [nucleotide binding] 932677006449 dimerization interface [polypeptide binding]; other site 932677006450 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 932677006451 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932677006452 dimer interface [polypeptide binding]; other site 932677006453 phosphorylation site [posttranslational modification] 932677006454 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677006455 ATP binding site [chemical binding]; other site 932677006456 Mg2+ binding site [ion binding]; other site 932677006457 G-X-G motif; other site 932677006458 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 932677006459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677006460 active site 932677006461 phosphorylation site [posttranslational modification] 932677006462 intermolecular recognition site; other site 932677006463 dimerization interface [polypeptide binding]; other site 932677006464 DNA gyrase subunit A; Validated; Region: PRK05560 932677006465 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 932677006466 CAP-like domain; other site 932677006467 active site 932677006468 primary dimer interface [polypeptide binding]; other site 932677006469 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 932677006470 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 932677006471 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 932677006472 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 932677006473 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 932677006474 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 932677006475 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 932677006476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677006477 S-adenosylmethionine binding site [chemical binding]; other site 932677006478 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 932677006479 ATP cone domain; Region: ATP-cone; pfam03477 932677006480 Class I ribonucleotide reductase; Region: RNR_I; cd01679 932677006481 active site 932677006482 dimer interface [polypeptide binding]; other site 932677006483 catalytic residues [active] 932677006484 effector binding site; other site 932677006485 R2 peptide binding site; other site 932677006486 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 932677006487 dimer interface [polypeptide binding]; other site 932677006488 putative radical transfer pathway; other site 932677006489 diiron center [ion binding]; other site 932677006490 tyrosyl radical; other site 932677006491 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 932677006492 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 932677006493 catalytic loop [active] 932677006494 iron binding site [ion binding]; other site 932677006495 hypothetical protein; Provisional; Region: PRK03673 932677006496 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 932677006497 putative MPT binding site; other site 932677006498 hypothetical protein; Provisional; Region: PRK10404 932677006499 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 932677006500 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 932677006501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 932677006502 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 932677006503 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 932677006504 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 932677006505 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 932677006506 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 932677006507 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 932677006508 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 932677006509 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 932677006510 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 932677006511 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 932677006512 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 932677006513 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 932677006514 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 932677006515 4Fe-4S binding domain; Region: Fer4; pfam00037 932677006516 4Fe-4S binding domain; Region: Fer4; pfam00037 932677006517 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 932677006518 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 932677006519 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 932677006520 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 932677006521 catalytic loop [active] 932677006522 iron binding site [ion binding]; other site 932677006523 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 932677006524 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 932677006525 [4Fe-4S] binding site [ion binding]; other site 932677006526 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 932677006527 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 932677006528 SLBB domain; Region: SLBB; pfam10531 932677006529 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 932677006530 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 932677006531 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 932677006532 putative dimer interface [polypeptide binding]; other site 932677006533 [2Fe-2S] cluster binding site [ion binding]; other site 932677006534 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 932677006535 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 932677006536 NADH dehydrogenase subunit D; Validated; Region: PRK06075 932677006537 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 932677006538 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 932677006539 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 932677006540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677006541 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 932677006542 putative dimerization interface [polypeptide binding]; other site 932677006543 aminotransferase AlaT; Validated; Region: PRK09265 932677006544 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932677006545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677006546 homodimer interface [polypeptide binding]; other site 932677006547 catalytic residue [active] 932677006548 5'-nucleotidase; Provisional; Region: PRK03826 932677006549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677006550 motif II; other site 932677006551 hypothetical protein; Validated; Region: PRK05445 932677006552 hypothetical protein; Provisional; Region: PRK01816 932677006553 propionate/acetate kinase; Provisional; Region: PRK12379 932677006554 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 932677006555 phosphate acetyltransferase; Reviewed; Region: PRK05632 932677006556 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 932677006557 DRTGG domain; Region: DRTGG; pfam07085 932677006558 phosphate acetyltransferase; Region: pta; TIGR00651 932677006559 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 932677006560 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 932677006561 Walker A/P-loop; other site 932677006562 ATP binding site [chemical binding]; other site 932677006563 Q-loop/lid; other site 932677006564 ABC transporter signature motif; other site 932677006565 Walker B; other site 932677006566 D-loop; other site 932677006567 H-loop/switch region; other site 932677006568 TOBE domain; Region: TOBE_2; pfam08402 932677006569 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932677006570 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 932677006571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677006572 homodimer interface [polypeptide binding]; other site 932677006573 catalytic residue [active] 932677006574 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 932677006575 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 932677006576 inhibitor-cofactor binding pocket; inhibition site 932677006577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677006578 catalytic residue [active] 932677006579 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 932677006580 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 932677006581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677006582 dimer interface [polypeptide binding]; other site 932677006583 conserved gate region; other site 932677006584 putative PBP binding loops; other site 932677006585 ABC-ATPase subunit interface; other site 932677006586 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 932677006587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677006588 dimer interface [polypeptide binding]; other site 932677006589 conserved gate region; other site 932677006590 putative PBP binding loops; other site 932677006591 ABC-ATPase subunit interface; other site 932677006592 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 932677006593 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 932677006594 NAD(P) binding site [chemical binding]; other site 932677006595 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932677006596 salt bridge; other site 932677006597 non-specific DNA binding site [nucleotide binding]; other site 932677006598 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 932677006599 sequence-specific DNA binding site [nucleotide binding]; other site 932677006600 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 932677006601 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 932677006602 nudix motif; other site 932677006603 glutathione S-transferase; Provisional; Region: PRK15113 932677006604 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 932677006605 C-terminal domain interface [polypeptide binding]; other site 932677006606 GSH binding site (G-site) [chemical binding]; other site 932677006607 dimer interface [polypeptide binding]; other site 932677006608 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 932677006609 N-terminal domain interface [polypeptide binding]; other site 932677006610 putative dimer interface [polypeptide binding]; other site 932677006611 putative substrate binding pocket (H-site) [chemical binding]; other site 932677006612 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 932677006613 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 932677006614 putative NAD(P) binding site [chemical binding]; other site 932677006615 putative active site [active] 932677006616 polyol permease family; Region: 2A0118; TIGR00897 932677006617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677006618 putative substrate translocation pore; other site 932677006619 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 932677006620 N- and C-terminal domain interface [polypeptide binding]; other site 932677006621 D-xylulose kinase; Region: XylB; TIGR01312 932677006622 active site 932677006623 MgATP binding site [chemical binding]; other site 932677006624 catalytic site [active] 932677006625 metal binding site [ion binding]; metal-binding site 932677006626 xylulose binding site [chemical binding]; other site 932677006627 homodimer interface [polypeptide binding]; other site 932677006628 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 932677006629 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 932677006630 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 932677006631 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 932677006632 MarR family; Region: MarR_2; pfam12802 932677006633 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 932677006634 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 932677006635 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 932677006636 Walker A/P-loop; other site 932677006637 ATP binding site [chemical binding]; other site 932677006638 Q-loop/lid; other site 932677006639 ABC transporter signature motif; other site 932677006640 Walker B; other site 932677006641 D-loop; other site 932677006642 H-loop/switch region; other site 932677006643 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 932677006644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677006645 dimer interface [polypeptide binding]; other site 932677006646 conserved gate region; other site 932677006647 putative PBP binding loops; other site 932677006648 ABC-ATPase subunit interface; other site 932677006649 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 932677006650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677006651 dimer interface [polypeptide binding]; other site 932677006652 conserved gate region; other site 932677006653 putative PBP binding loops; other site 932677006654 ABC-ATPase subunit interface; other site 932677006655 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 932677006656 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677006657 substrate binding pocket [chemical binding]; other site 932677006658 membrane-bound complex binding site; other site 932677006659 hinge residues; other site 932677006660 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 932677006661 Flavoprotein; Region: Flavoprotein; pfam02441 932677006662 amidophosphoribosyltransferase; Provisional; Region: PRK09246 932677006663 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 932677006664 active site 932677006665 tetramer interface [polypeptide binding]; other site 932677006666 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932677006667 active site 932677006668 colicin V production protein; Provisional; Region: PRK10845 932677006669 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 932677006670 cell division protein DedD; Provisional; Region: PRK11633 932677006671 Sporulation related domain; Region: SPOR; pfam05036 932677006672 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 932677006673 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 932677006674 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 932677006675 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 932677006676 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 932677006677 hypothetical protein; Provisional; Region: PRK10847 932677006678 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 932677006679 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 932677006680 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 932677006681 dimerization interface 3.5A [polypeptide binding]; other site 932677006682 active site 932677006683 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 932677006684 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 932677006685 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 932677006686 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 932677006687 ligand binding site [chemical binding]; other site 932677006688 NAD binding site [chemical binding]; other site 932677006689 catalytic site [active] 932677006690 homodimer interface [polypeptide binding]; other site 932677006691 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 932677006692 EamA-like transporter family; Region: EamA; pfam00892 932677006693 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 932677006694 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 932677006695 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932677006696 dimer interface [polypeptide binding]; other site 932677006697 phosphorylation site [posttranslational modification] 932677006698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677006699 ATP binding site [chemical binding]; other site 932677006700 Mg2+ binding site [ion binding]; other site 932677006701 G-X-G motif; other site 932677006702 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 932677006703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677006704 active site 932677006705 phosphorylation site [posttranslational modification] 932677006706 intermolecular recognition site; other site 932677006707 dimerization interface [polypeptide binding]; other site 932677006708 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932677006709 DNA binding site [nucleotide binding] 932677006710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 932677006711 potential protein location (hypothetical protein hypothetical protein) that overlaps protein (tricarboxylate transport protein TctC) 932677006712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 932677006713 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 932677006714 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 932677006715 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932677006716 DNA-binding site [nucleotide binding]; DNA binding site 932677006717 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932677006718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677006719 homodimer interface [polypeptide binding]; other site 932677006720 catalytic residue [active] 932677006721 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 932677006722 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 932677006723 dimer interface [polypeptide binding]; other site 932677006724 active site 932677006725 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 932677006726 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 932677006727 YfcL protein; Region: YfcL; pfam08891 932677006728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 932677006729 hypothetical protein; Provisional; Region: PRK10621 932677006730 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 932677006731 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 932677006732 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 932677006733 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 932677006734 Tetramer interface [polypeptide binding]; other site 932677006735 active site 932677006736 FMN-binding site [chemical binding]; other site 932677006737 HemK family putative methylases; Region: hemK_fam; TIGR00536 932677006738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677006739 S-adenosylmethionine binding site [chemical binding]; other site 932677006740 potential protein location (hypothetical protein) that overlaps protein (methylase HemK family protein YfcB) 932677006741 hypothetical protein; Provisional; Region: PRK04946 932677006742 Smr domain; Region: Smr; pfam01713 932677006743 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932677006744 dimerization interface [polypeptide binding]; other site 932677006745 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 932677006746 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677006747 dimer interface [polypeptide binding]; other site 932677006748 putative CheW interface [polypeptide binding]; other site 932677006749 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932677006750 catalytic core [active] 932677006751 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 932677006752 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 932677006753 substrate binding site [chemical binding]; other site 932677006754 oxyanion hole (OAH) forming residues; other site 932677006755 trimer interface [polypeptide binding]; other site 932677006756 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 932677006757 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 932677006758 potential protein location (hypothetical protein) that overlaps protein (fatty acid oxidation complex alpha subunit FadJ) 932677006759 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 932677006760 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 932677006761 dimer interface [polypeptide binding]; other site 932677006762 active site 932677006763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 932677006764 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 932677006765 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 932677006766 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 932677006767 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 932677006768 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932677006769 binding surface 932677006770 TPR motif; other site 932677006771 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 932677006772 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 932677006773 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 932677006774 catalytic residues [active] 932677006775 central insert; other site 932677006776 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 932677006777 CcmE; Region: CcmE; cl00994 932677006778 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 932677006779 heme exporter protein CcmC; Region: ccmC; TIGR01191 932677006780 heme exporter protein CcmB; Region: ccmB; TIGR01190 932677006781 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 932677006782 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 932677006783 Walker A/P-loop; other site 932677006784 ATP binding site [chemical binding]; other site 932677006785 Q-loop/lid; other site 932677006786 ABC transporter signature motif; other site 932677006787 Walker B; other site 932677006788 D-loop; other site 932677006789 H-loop/switch region; other site 932677006790 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 932677006791 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 932677006792 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 932677006793 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 932677006794 putative active site [active] 932677006795 catalytic site [active] 932677006796 putative metal binding site [ion binding]; other site 932677006797 oligomer interface [polypeptide binding]; other site 932677006798 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 932677006799 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677006800 Walker A/P-loop; other site 932677006801 ATP binding site [chemical binding]; other site 932677006802 Q-loop/lid; other site 932677006803 ABC transporter signature motif; other site 932677006804 Walker B; other site 932677006805 D-loop; other site 932677006806 H-loop/switch region; other site 932677006807 TOBE domain; Region: TOBE_2; pfam08402 932677006808 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 932677006809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677006810 dimer interface [polypeptide binding]; other site 932677006811 conserved gate region; other site 932677006812 putative PBP binding loops; other site 932677006813 ABC-ATPase subunit interface; other site 932677006814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677006815 dimer interface [polypeptide binding]; other site 932677006816 conserved gate region; other site 932677006817 putative PBP binding loops; other site 932677006818 ABC-ATPase subunit interface; other site 932677006819 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 932677006820 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 932677006821 Transcriptional regulators [Transcription]; Region: MarR; COG1846 932677006822 MarR family; Region: MarR_2; pfam12802 932677006823 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932677006824 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932677006825 nucleotide binding site [chemical binding]; other site 932677006826 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 932677006827 Fimbrial protein; Region: Fimbrial; cl01416 932677006828 Fimbrial protein; Region: Fimbrial; pfam00419 932677006829 Fimbrial protein; Region: Fimbrial; pfam00419 932677006830 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 932677006831 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 932677006832 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 932677006833 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 932677006834 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 932677006835 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 932677006836 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 932677006837 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 932677006838 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 932677006839 PapC N-terminal domain; Region: PapC_N; pfam13954 932677006840 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 932677006841 PapC C-terminal domain; Region: PapC_C; pfam13953 932677006842 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 932677006843 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 932677006844 RES domain; Region: RES; cl02411 932677006845 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 932677006846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677006847 putative substrate translocation pore; other site 932677006848 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 932677006849 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 932677006850 Transcriptional regulator [Transcription]; Region: IclR; COG1414 932677006851 Bacterial transcriptional regulator; Region: IclR; pfam01614 932677006852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677006853 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932677006854 putative substrate translocation pore; other site 932677006855 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 932677006856 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 932677006857 HlyD family secretion protein; Region: HlyD_3; pfam13437 932677006858 aminotransferase; Validated; Region: PRK08175 932677006859 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932677006860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677006861 homodimer interface [polypeptide binding]; other site 932677006862 catalytic residue [active] 932677006863 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 932677006864 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677006865 Coenzyme A binding pocket [chemical binding]; other site 932677006866 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 932677006867 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 932677006868 GAF domain; Region: GAF_3; pfam13492 932677006869 Histidine kinase; Region: His_kinase; pfam06580 932677006870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677006871 ATP binding site [chemical binding]; other site 932677006872 Mg2+ binding site [ion binding]; other site 932677006873 G-X-G motif; other site 932677006874 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 932677006875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677006876 active site 932677006877 phosphorylation site [posttranslational modification] 932677006878 intermolecular recognition site; other site 932677006879 dimerization interface [polypeptide binding]; other site 932677006880 LytTr DNA-binding domain; Region: LytTR; pfam04397 932677006881 glucokinase, proteobacterial type; Region: glk; TIGR00749 932677006882 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932677006883 nucleotide binding site [chemical binding]; other site 932677006884 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 932677006885 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 932677006886 dimer interface [polypeptide binding]; other site 932677006887 PYR/PP interface [polypeptide binding]; other site 932677006888 TPP binding site [chemical binding]; other site 932677006889 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 932677006890 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 932677006891 TPP-binding site [chemical binding]; other site 932677006892 dimer interface [polypeptide binding]; other site 932677006893 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932677006894 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932677006895 active site 932677006896 catalytic tetrad [active] 932677006897 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 932677006898 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 932677006899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677006900 S-adenosylmethionine binding site [chemical binding]; other site 932677006901 manganese transport protein MntH; Reviewed; Region: PRK00701 932677006902 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 932677006903 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 932677006904 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 932677006905 Nucleoside recognition; Region: Gate; pfam07670 932677006906 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 932677006907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 932677006908 HTH-like domain; Region: HTH_21; pfam13276 932677006909 Integrase core domain; Region: rve; pfam00665 932677006910 Integrase core domain; Region: rve_3; pfam13683 932677006911 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 932677006912 active site 932677006913 NTP binding site [chemical binding]; other site 932677006914 metal binding triad [ion binding]; metal-binding site 932677006915 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 932677006916 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 932677006917 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 932677006918 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 932677006919 active site 932677006920 HIGH motif; other site 932677006921 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 932677006922 active site 932677006923 KMSKS motif; other site 932677006924 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677006925 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677006926 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 932677006927 putative dimerization interface [polypeptide binding]; other site 932677006928 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 932677006929 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 932677006930 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 932677006931 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 932677006932 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 932677006933 nucleotide binding pocket [chemical binding]; other site 932677006934 K-X-D-G motif; other site 932677006935 catalytic site [active] 932677006936 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 932677006937 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 932677006938 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 932677006939 Dimer interface [polypeptide binding]; other site 932677006940 BRCT sequence motif; other site 932677006941 cell division protein ZipA; Provisional; Region: PRK03427 932677006942 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 932677006943 FtsZ protein binding site [polypeptide binding]; other site 932677006944 putative sulfate transport protein CysZ; Validated; Region: PRK04949 932677006945 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 932677006946 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 932677006947 dimer interface [polypeptide binding]; other site 932677006948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677006949 catalytic residue [active] 932677006950 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 932677006951 dimerization domain swap beta strand [polypeptide binding]; other site 932677006952 regulatory protein interface [polypeptide binding]; other site 932677006953 active site 932677006954 regulatory phosphorylation site [posttranslational modification]; other site 932677006955 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 932677006956 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 932677006957 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 932677006958 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 932677006959 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 932677006960 HPr interaction site; other site 932677006961 glycerol kinase (GK) interaction site [polypeptide binding]; other site 932677006962 active site 932677006963 phosphorylation site [posttranslational modification] 932677006964 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932677006965 dimerization interface [polypeptide binding]; other site 932677006966 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932677006967 dimer interface [polypeptide binding]; other site 932677006968 phosphorylation site [posttranslational modification] 932677006969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677006970 ATP binding site [chemical binding]; other site 932677006971 Mg2+ binding site [ion binding]; other site 932677006972 G-X-G motif; other site 932677006973 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932677006974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677006975 active site 932677006976 phosphorylation site [posttranslational modification] 932677006977 intermolecular recognition site; other site 932677006978 dimerization interface [polypeptide binding]; other site 932677006979 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932677006980 DNA binding site [nucleotide binding] 932677006981 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 932677006982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677006983 dimer interface [polypeptide binding]; other site 932677006984 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 932677006985 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 932677006986 Walker A/P-loop; other site 932677006987 ATP binding site [chemical binding]; other site 932677006988 Q-loop/lid; other site 932677006989 ABC transporter signature motif; other site 932677006990 Walker B; other site 932677006991 D-loop; other site 932677006992 H-loop/switch region; other site 932677006993 TOBE-like domain; Region: TOBE_3; pfam12857 932677006994 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 932677006995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677006996 dimer interface [polypeptide binding]; other site 932677006997 conserved gate region; other site 932677006998 putative PBP binding loops; other site 932677006999 ABC-ATPase subunit interface; other site 932677007000 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 932677007001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677007002 dimer interface [polypeptide binding]; other site 932677007003 conserved gate region; other site 932677007004 putative PBP binding loops; other site 932677007005 ABC-ATPase subunit interface; other site 932677007006 thiosulfate transporter subunit; Provisional; Region: PRK10852 932677007007 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 932677007008 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 932677007009 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 932677007010 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 932677007011 putative acetyltransferase; Provisional; Region: PRK03624 932677007012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677007013 Coenzyme A binding pocket [chemical binding]; other site 932677007014 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 932677007015 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 932677007016 active site 932677007017 metal binding site [ion binding]; metal-binding site 932677007018 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 932677007019 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 932677007020 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 932677007021 Malic enzyme, N-terminal domain; Region: malic; pfam00390 932677007022 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 932677007023 putative NAD(P) binding site [chemical binding]; other site 932677007024 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 932677007025 transaldolase-like protein; Provisional; Region: PTZ00411 932677007026 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 932677007027 active site 932677007028 dimer interface [polypeptide binding]; other site 932677007029 catalytic residue [active] 932677007030 transketolase; Reviewed; Region: PRK12753 932677007031 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 932677007032 TPP-binding site [chemical binding]; other site 932677007033 dimer interface [polypeptide binding]; other site 932677007034 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 932677007035 PYR/PP interface [polypeptide binding]; other site 932677007036 dimer interface [polypeptide binding]; other site 932677007037 TPP binding site [chemical binding]; other site 932677007038 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 932677007039 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 932677007040 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 932677007041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932677007042 putative active site [active] 932677007043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677007044 ATP binding site [chemical binding]; other site 932677007045 Mg2+ binding site [ion binding]; other site 932677007046 G-X-G motif; other site 932677007047 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 932677007048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677007049 active site 932677007050 phosphorylation site [posttranslational modification] 932677007051 intermolecular recognition site; other site 932677007052 dimerization interface [polypeptide binding]; other site 932677007053 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 932677007054 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 932677007055 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 932677007056 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 932677007057 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 932677007058 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 932677007059 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 932677007060 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 932677007061 ligand binding site [chemical binding]; other site 932677007062 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 932677007063 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 932677007064 Walker A/P-loop; other site 932677007065 ATP binding site [chemical binding]; other site 932677007066 Q-loop/lid; other site 932677007067 ABC transporter signature motif; other site 932677007068 Walker B; other site 932677007069 D-loop; other site 932677007070 H-loop/switch region; other site 932677007071 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 932677007072 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932677007073 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 932677007074 TM-ABC transporter signature motif; other site 932677007075 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932677007076 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 932677007077 TM-ABC transporter signature motif; other site 932677007078 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 932677007079 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 932677007080 substrate binding site [chemical binding]; other site 932677007081 hexamer interface [polypeptide binding]; other site 932677007082 metal binding site [ion binding]; metal-binding site 932677007083 D-allose kinase; Provisional; Region: PRK09698 932677007084 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932677007085 nucleotide binding site [chemical binding]; other site 932677007086 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 932677007087 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 932677007088 substrate binding site [chemical binding]; other site 932677007089 dimer interface [polypeptide binding]; other site 932677007090 ATP binding site [chemical binding]; other site 932677007091 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 932677007092 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 932677007093 dimer interface [polypeptide binding]; other site 932677007094 ADP-ribose binding site [chemical binding]; other site 932677007095 active site 932677007096 nudix motif; other site 932677007097 metal binding site [ion binding]; metal-binding site 932677007098 L-asparagine permease; Provisional; Region: PRK15049 932677007099 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 932677007100 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 932677007101 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 932677007102 HAMP domain; Region: HAMP; pfam00672 932677007103 Histidine kinase; Region: HisKA_3; pfam07730 932677007104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677007105 ATP binding site [chemical binding]; other site 932677007106 Mg2+ binding site [ion binding]; other site 932677007107 G-X-G motif; other site 932677007108 transcriptional regulator NarP; Provisional; Region: PRK10403 932677007109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677007110 active site 932677007111 phosphorylation site [posttranslational modification] 932677007112 intermolecular recognition site; other site 932677007113 dimerization interface [polypeptide binding]; other site 932677007114 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 932677007115 DNA binding residues [nucleotide binding] 932677007116 dimerization interface [polypeptide binding]; other site 932677007117 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 932677007118 Protein export membrane protein; Region: SecD_SecF; cl14618 932677007119 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 932677007120 ArsC family; Region: ArsC; pfam03960 932677007121 putative catalytic residues [active] 932677007122 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 932677007123 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 932677007124 metal binding site [ion binding]; metal-binding site 932677007125 dimer interface [polypeptide binding]; other site 932677007126 putative hydrolase; Provisional; Region: PRK11460 932677007127 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 932677007128 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 932677007129 Helicase; Region: Helicase_RecD; pfam05127 932677007130 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 932677007131 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 932677007132 Predicted metalloprotease [General function prediction only]; Region: COG2321 932677007133 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 932677007134 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 932677007135 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 932677007136 ATP binding site [chemical binding]; other site 932677007137 active site 932677007138 substrate binding site [chemical binding]; other site 932677007139 lipoprotein; Provisional; Region: PRK11679 932677007140 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 932677007141 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 932677007142 dihydrodipicolinate synthase; Region: dapA; TIGR00674 932677007143 dimer interface [polypeptide binding]; other site 932677007144 active site 932677007145 catalytic residue [active] 932677007146 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 932677007147 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 932677007148 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 932677007149 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 932677007150 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 932677007151 catalytic triad [active] 932677007152 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 932677007153 Domain of unknown function DUF20; Region: UPF0118; pfam01594 932677007154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 932677007155 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 932677007156 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 932677007157 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 932677007158 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 932677007159 Helix-turn-helix domain; Region: HTH_18; pfam12833 932677007160 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677007161 Cache domain; Region: Cache_1; pfam02743 932677007162 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932677007163 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932677007164 metal binding site [ion binding]; metal-binding site 932677007165 active site 932677007166 I-site; other site 932677007167 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 932677007168 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 932677007169 active site 932677007170 metal binding site [ion binding]; metal-binding site 932677007171 hexamer interface [polypeptide binding]; other site 932677007172 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 932677007173 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677007174 Walker A/P-loop; other site 932677007175 ATP binding site [chemical binding]; other site 932677007176 Q-loop/lid; other site 932677007177 ABC transporter signature motif; other site 932677007178 Walker B; other site 932677007179 D-loop; other site 932677007180 H-loop/switch region; other site 932677007181 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 932677007182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677007183 dimer interface [polypeptide binding]; other site 932677007184 conserved gate region; other site 932677007185 putative PBP binding loops; other site 932677007186 ABC-ATPase subunit interface; other site 932677007187 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 932677007188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677007189 dimer interface [polypeptide binding]; other site 932677007190 conserved gate region; other site 932677007191 putative PBP binding loops; other site 932677007192 ABC-ATPase subunit interface; other site 932677007193 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 932677007194 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 932677007195 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932677007196 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932677007197 DNA binding site [nucleotide binding] 932677007198 domain linker motif; other site 932677007199 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 932677007200 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 932677007201 Peptidase family M48; Region: Peptidase_M48; pfam01435 932677007202 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 932677007203 ArsC family; Region: ArsC; pfam03960 932677007204 catalytic residues [active] 932677007205 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 932677007206 DNA replication initiation factor; Provisional; Region: PRK08084 932677007207 uracil transporter; Provisional; Region: PRK10720 932677007208 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932677007209 active site 932677007210 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 932677007211 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 932677007212 dimerization interface [polypeptide binding]; other site 932677007213 putative ATP binding site [chemical binding]; other site 932677007214 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 932677007215 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 932677007216 active site 932677007217 substrate binding site [chemical binding]; other site 932677007218 cosubstrate binding site; other site 932677007219 catalytic site [active] 932677007220 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 932677007221 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 932677007222 Walker A/P-loop; other site 932677007223 ATP binding site [chemical binding]; other site 932677007224 Q-loop/lid; other site 932677007225 ABC transporter signature motif; other site 932677007226 Walker B; other site 932677007227 D-loop; other site 932677007228 H-loop/switch region; other site 932677007229 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 932677007230 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 932677007231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677007232 ABC-ATPase subunit interface; other site 932677007233 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 932677007234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677007235 ABC-ATPase subunit interface; other site 932677007236 polyphosphate kinase; Provisional; Region: PRK05443 932677007237 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 932677007238 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 932677007239 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 932677007240 domain interface [polypeptide binding]; other site 932677007241 active site 932677007242 catalytic site [active] 932677007243 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 932677007244 domain interface [polypeptide binding]; other site 932677007245 active site 932677007246 catalytic site [active] 932677007247 exopolyphosphatase; Provisional; Region: PRK10854 932677007248 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932677007249 nucleotide binding site [chemical binding]; other site 932677007250 tellurite resistance protein TehB; Provisional; Region: PRK11207 932677007251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677007252 S-adenosylmethionine binding site [chemical binding]; other site 932677007253 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 932677007254 MgtE intracellular N domain; Region: MgtE_N; smart00924 932677007255 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 932677007256 Divalent cation transporter; Region: MgtE; cl00786 932677007257 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 932677007258 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 932677007259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932677007260 TPR motif; other site 932677007261 binding surface 932677007262 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 932677007263 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 932677007264 substrate binding pocket [chemical binding]; other site 932677007265 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 932677007266 EamA-like transporter family; Region: EamA; pfam00892 932677007267 EamA-like transporter family; Region: EamA; pfam00892 932677007268 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 932677007269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677007270 AAA domain; Region: AAA_23; pfam13476 932677007271 Walker A/P-loop; other site 932677007272 ATP binding site [chemical binding]; other site 932677007273 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677007274 AAA domain; Region: AAA_21; pfam13304 932677007275 ABC transporter signature motif; other site 932677007276 Walker B; other site 932677007277 D-loop; other site 932677007278 H-loop/switch region; other site 932677007279 P-type conjugative transfer protein TrbJ; Region: TrbJ_Ti; TIGR02780 932677007280 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 932677007281 Replication protein C (RepC); Region: RepC; pfam06504 932677007282 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 932677007283 AAA domain; Region: AAA_25; pfam13481 932677007284 ATP binding site [chemical binding]; other site 932677007285 Walker B motif; other site 932677007286 integrase; Provisional; Region: PRK09692 932677007287 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 932677007288 active site 932677007289 Int/Topo IB signature motif; other site 932677007290 GMP synthase; Reviewed; Region: guaA; PRK00074 932677007291 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 932677007292 AMP/PPi binding site [chemical binding]; other site 932677007293 candidate oxyanion hole; other site 932677007294 catalytic triad [active] 932677007295 potential glutamine specificity residues [chemical binding]; other site 932677007296 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 932677007297 ATP Binding subdomain [chemical binding]; other site 932677007298 Ligand Binding sites [chemical binding]; other site 932677007299 Dimerization subdomain; other site 932677007300 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 932677007301 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 932677007302 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 932677007303 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 932677007304 active site 932677007305 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 932677007306 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 932677007307 generic binding surface II; other site 932677007308 generic binding surface I; other site 932677007309 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 932677007310 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 932677007311 active site 932677007312 Zn binding site [ion binding]; other site 932677007313 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 932677007314 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 932677007315 Trp docking motif [polypeptide binding]; other site 932677007316 putative active site [active] 932677007317 GTP-binding protein Der; Reviewed; Region: PRK00093 932677007318 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 932677007319 G1 box; other site 932677007320 GTP/Mg2+ binding site [chemical binding]; other site 932677007321 Switch I region; other site 932677007322 G2 box; other site 932677007323 Switch II region; other site 932677007324 G3 box; other site 932677007325 G4 box; other site 932677007326 G5 box; other site 932677007327 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 932677007328 G1 box; other site 932677007329 GTP/Mg2+ binding site [chemical binding]; other site 932677007330 Switch I region; other site 932677007331 G2 box; other site 932677007332 G3 box; other site 932677007333 Switch II region; other site 932677007334 G4 box; other site 932677007335 G5 box; other site 932677007336 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 932677007337 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 932677007338 Trp docking motif [polypeptide binding]; other site 932677007339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 932677007340 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 932677007341 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 932677007342 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 932677007343 dimer interface [polypeptide binding]; other site 932677007344 motif 1; other site 932677007345 active site 932677007346 motif 2; other site 932677007347 motif 3; other site 932677007348 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 932677007349 anticodon binding site; other site 932677007350 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 932677007351 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 932677007352 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 932677007353 cytoskeletal protein RodZ; Provisional; Region: PRK10856 932677007354 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932677007355 non-specific DNA binding site [nucleotide binding]; other site 932677007356 salt bridge; other site 932677007357 sequence-specific DNA binding site [nucleotide binding]; other site 932677007358 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 932677007359 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 932677007360 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 932677007361 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 932677007362 FeS/SAM binding site; other site 932677007363 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 932677007364 active site 932677007365 multimer interface [polypeptide binding]; other site 932677007366 Transglycosylase; Region: Transgly; pfam00912 932677007367 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 932677007368 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 932677007369 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 932677007370 MG2 domain; Region: A2M_N; pfam01835 932677007371 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 932677007372 surface patch; other site 932677007373 thioester region; other site 932677007374 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 932677007375 active site residue [active] 932677007376 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 932677007377 active site residue [active] 932677007378 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 932677007379 aminopeptidase B; Provisional; Region: PRK05015 932677007380 Peptidase; Region: DUF3663; pfam12404 932677007381 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 932677007382 interface (dimer of trimers) [polypeptide binding]; other site 932677007383 Substrate-binding/catalytic site; other site 932677007384 Zn-binding sites [ion binding]; other site 932677007385 cysteine desulfurase; Provisional; Region: PRK14012 932677007386 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 932677007387 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932677007388 catalytic residue [active] 932677007389 potential protein location (hypothetical protein) that overlaps protein (cysteine desulfurase IscS) 932677007390 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 932677007391 Rrf2 family protein; Region: rrf2_super; TIGR00738 932677007392 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 932677007393 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 932677007394 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 932677007395 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 932677007396 active site 932677007397 dimerization interface [polypeptide binding]; other site 932677007398 potential protein location (hypothetical protein) that overlaps protein (Inositol-1-monophosphatase SuhB) 932677007399 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 932677007400 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 932677007401 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 932677007402 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 932677007403 PRD domain; Region: PRD; pfam00874 932677007404 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 932677007405 MFS_1 like family; Region: MFS_1_like; pfam12832 932677007406 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 932677007407 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 932677007408 dimer interface [polypeptide binding]; other site 932677007409 active site 932677007410 glycine-pyridoxal phosphate binding site [chemical binding]; other site 932677007411 folate binding site [chemical binding]; other site 932677007412 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 932677007413 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 932677007414 heme-binding site [chemical binding]; other site 932677007415 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 932677007416 FAD binding pocket [chemical binding]; other site 932677007417 FAD binding motif [chemical binding]; other site 932677007418 phosphate binding motif [ion binding]; other site 932677007419 beta-alpha-beta structure motif; other site 932677007420 NAD binding pocket [chemical binding]; other site 932677007421 Heme binding pocket [chemical binding]; other site 932677007422 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 932677007423 Nitrogen regulatory protein P-II; Region: P-II; smart00938 932677007424 response regulator GlrR; Provisional; Region: PRK15115 932677007425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677007426 active site 932677007427 phosphorylation site [posttranslational modification] 932677007428 intermolecular recognition site; other site 932677007429 dimerization interface [polypeptide binding]; other site 932677007430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677007431 Walker A motif; other site 932677007432 ATP binding site [chemical binding]; other site 932677007433 Walker B motif; other site 932677007434 arginine finger; other site 932677007435 hypothetical protein; Provisional; Region: PRK10722 932677007436 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 932677007437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932677007438 dimer interface [polypeptide binding]; other site 932677007439 phosphorylation site [posttranslational modification] 932677007440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677007441 ATP binding site [chemical binding]; other site 932677007442 Mg2+ binding site [ion binding]; other site 932677007443 G-X-G motif; other site 932677007444 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 932677007445 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 932677007446 dimerization interface [polypeptide binding]; other site 932677007447 ATP binding site [chemical binding]; other site 932677007448 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 932677007449 dimerization interface [polypeptide binding]; other site 932677007450 ATP binding site [chemical binding]; other site 932677007451 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 932677007452 putative active site [active] 932677007453 catalytic triad [active] 932677007454 potential protein location (hypothetical protein) that overlaps protein (phosphoribosylformylglycinamidine synthase PurL) 932677007455 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623 932677007456 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677007457 substrate binding pocket [chemical binding]; other site 932677007458 membrane-bound complex binding site; other site 932677007459 hinge residues; other site 932677007460 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 932677007461 N-acetyl-D-glucosamine binding site [chemical binding]; other site 932677007462 catalytic residue [active] 932677007463 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 932677007464 nucleoside/Zn binding site; other site 932677007465 dimer interface [polypeptide binding]; other site 932677007466 catalytic motif [active] 932677007467 hypothetical protein; Provisional; Region: PRK11590 932677007468 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 932677007469 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932677007470 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 932677007471 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932677007472 putative active site [active] 932677007473 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 932677007474 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 932677007475 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 932677007476 active site 932677007477 hydrophilic channel; other site 932677007478 dimerization interface [polypeptide binding]; other site 932677007479 catalytic residues [active] 932677007480 active site lid [active] 932677007481 potential protein location (hypothetical protein) that overlaps protein (pyridoxal phosphate biosynthetic protein PdxJ) 932677007482 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 932677007483 Recombination protein O N terminal; Region: RecO_N; pfam11967 932677007484 Recombination protein O C terminal; Region: RecO_C; pfam02565 932677007485 GTPase Era; Reviewed; Region: era; PRK00089 932677007486 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 932677007487 G1 box; other site 932677007488 GTP/Mg2+ binding site [chemical binding]; other site 932677007489 Switch I region; other site 932677007490 G2 box; other site 932677007491 Switch II region; other site 932677007492 G3 box; other site 932677007493 G4 box; other site 932677007494 G5 box; other site 932677007495 KH domain; Region: KH_2; pfam07650 932677007496 ribonuclease III; Reviewed; Region: rnc; PRK00102 932677007497 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 932677007498 dimerization interface [polypeptide binding]; other site 932677007499 active site 932677007500 metal binding site [ion binding]; metal-binding site 932677007501 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 932677007502 dsRNA binding site [nucleotide binding]; other site 932677007503 signal peptidase I; Provisional; Region: PRK10861 932677007504 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 932677007505 Catalytic site [active] 932677007506 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 932677007507 GTP-binding protein LepA; Provisional; Region: PRK05433 932677007508 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 932677007509 G1 box; other site 932677007510 putative GEF interaction site [polypeptide binding]; other site 932677007511 GTP/Mg2+ binding site [chemical binding]; other site 932677007512 Switch I region; other site 932677007513 G2 box; other site 932677007514 G3 box; other site 932677007515 Switch II region; other site 932677007516 G4 box; other site 932677007517 G5 box; other site 932677007518 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 932677007519 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 932677007520 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 932677007521 SoxR reducing system protein RseC; Provisional; Region: PRK10862 932677007522 anti-sigma E factor; Provisional; Region: rseB; PRK09455 932677007523 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 932677007524 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 932677007525 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 932677007526 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 932677007527 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 932677007528 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 932677007529 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 932677007530 DNA binding residues [nucleotide binding] 932677007531 L-aspartate oxidase; Provisional; Region: PRK09077 932677007532 L-aspartate oxidase; Provisional; Region: PRK06175 932677007533 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 932677007534 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 932677007535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677007536 S-adenosylmethionine binding site [chemical binding]; other site 932677007537 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 932677007538 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 932677007539 ATP binding site [chemical binding]; other site 932677007540 Mg++ binding site [ion binding]; other site 932677007541 motif III; other site 932677007542 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932677007543 nucleotide binding region [chemical binding]; other site 932677007544 ATP-binding site [chemical binding]; other site 932677007545 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 932677007546 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 932677007547 ligand binding site [chemical binding]; other site 932677007548 active site 932677007549 UGI interface [polypeptide binding]; other site 932677007550 catalytic site [active] 932677007551 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 932677007552 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 932677007553 dimer interface [polypeptide binding]; other site 932677007554 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 932677007555 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 932677007556 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 932677007557 recombination and repair protein; Provisional; Region: PRK10869 932677007558 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 932677007559 Walker A/P-loop; other site 932677007560 ATP binding site [chemical binding]; other site 932677007561 Q-loop/lid; other site 932677007562 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 932677007563 Q-loop/lid; other site 932677007564 ABC transporter signature motif; other site 932677007565 Walker B; other site 932677007566 D-loop; other site 932677007567 H-loop/switch region; other site 932677007568 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 932677007569 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 932677007570 hypothetical protein; Validated; Region: PRK01777 932677007571 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 932677007572 putative coenzyme Q binding site [chemical binding]; other site 932677007573 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 932677007574 SmpB-tmRNA interface; other site 932677007575 integrase; Provisional; Region: PRK09692 932677007576 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 932677007577 active site 932677007578 Int/Topo IB signature motif; other site 932677007579 RES domain; Region: RES; pfam08808 932677007580 putative transposase OrfB; Reviewed; Region: PHA02517 932677007581 HTH-like domain; Region: HTH_21; pfam13276 932677007582 Integrase core domain; Region: rve; pfam00665 932677007583 Integrase core domain; Region: rve_3; pfam13683 932677007584 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 932677007585 active site 932677007586 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 932677007587 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 932677007588 Antirestriction protein; Region: Antirestrict; pfam03230 932677007589 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932677007590 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932677007591 haloalkane dehalogenase; Provisional; Region: PRK03592 932677007592 Epoxide hydrolase N terminus; Region: EHN; pfam06441 932677007593 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 932677007594 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 932677007595 N-terminal plug; other site 932677007596 ligand-binding site [chemical binding]; other site 932677007597 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 932677007598 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 932677007599 putative ligand binding residues [chemical binding]; other site 932677007600 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 932677007601 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932677007602 ABC-ATPase subunit interface; other site 932677007603 dimer interface [polypeptide binding]; other site 932677007604 putative PBP binding regions; other site 932677007605 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932677007606 ABC-ATPase subunit interface; other site 932677007607 dimer interface [polypeptide binding]; other site 932677007608 putative PBP binding regions; other site 932677007609 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 932677007610 ABC transporter signature motif; other site 932677007611 Walker B; other site 932677007612 D-loop; other site 932677007613 H-loop/switch region; other site 932677007614 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 932677007615 Transcriptional regulator [Transcription]; Region: IclR; COG1414 932677007616 Bacterial transcriptional regulator; Region: IclR; pfam01614 932677007617 hypothetical protein; Validated; Region: PRK06201 932677007618 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 932677007619 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 932677007620 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 932677007621 ligand binding site [chemical binding]; other site 932677007622 NAD binding site [chemical binding]; other site 932677007623 dimerization interface [polypeptide binding]; other site 932677007624 catalytic site [active] 932677007625 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 932677007626 Strictosidine synthase; Region: Str_synth; pfam03088 932677007627 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 932677007628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677007629 putative substrate translocation pore; other site 932677007630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677007631 D-galactonate transporter; Region: 2A0114; TIGR00893 932677007632 putative substrate translocation pore; other site 932677007633 transcriptional antiterminator BglG; Provisional; Region: PRK09772 932677007634 CAT RNA binding domain; Region: CAT_RBD; smart01061 932677007635 PRD domain; Region: PRD; pfam00874 932677007636 PRD domain; Region: PRD; pfam00874 932677007637 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 932677007638 active site 932677007639 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 932677007640 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 932677007641 putative NAD(P) binding site [chemical binding]; other site 932677007642 Predicted transcriptional regulators [Transcription]; Region: COG1733 932677007643 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 932677007644 Right handed beta helix region; Region: Beta_helix; pfam13229 932677007645 hypothetical protein; Provisional; Region: PRK09739 932677007646 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 932677007647 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677007648 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677007649 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 932677007650 putative effector binding pocket; other site 932677007651 putative dimerization interface [polypeptide binding]; other site 932677007652 Propionate catabolism activator; Region: PrpR_N; pfam06506 932677007653 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 932677007654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677007655 Walker A motif; other site 932677007656 ATP binding site [chemical binding]; other site 932677007657 Walker B motif; other site 932677007658 arginine finger; other site 932677007659 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 932677007660 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 932677007661 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 932677007662 active site 932677007663 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 932677007664 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 932677007665 transmembrane helices; other site 932677007666 hypothetical protein; Validated; Region: PRK06201 932677007667 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 932677007668 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 932677007669 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 932677007670 ligand binding site [chemical binding]; other site 932677007671 NAD binding site [chemical binding]; other site 932677007672 dimerization interface [polypeptide binding]; other site 932677007673 catalytic site [active] 932677007674 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 932677007675 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 932677007676 trimer interface [polypeptide binding]; other site 932677007677 eyelet of channel; other site 932677007678 Uncharacterized conserved protein [Function unknown]; Region: COG3791 932677007679 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 932677007680 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 932677007681 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932677007682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677007683 active site 932677007684 phosphorylation site [posttranslational modification] 932677007685 intermolecular recognition site; other site 932677007686 dimerization interface [polypeptide binding]; other site 932677007687 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932677007688 DNA binding site [nucleotide binding] 932677007689 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 932677007690 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932677007691 dimerization interface [polypeptide binding]; other site 932677007692 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932677007693 dimer interface [polypeptide binding]; other site 932677007694 phosphorylation site [posttranslational modification] 932677007695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677007696 ATP binding site [chemical binding]; other site 932677007697 Mg2+ binding site [ion binding]; other site 932677007698 G-X-G motif; other site 932677007699 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 932677007700 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 932677007701 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 932677007702 putative ligand binding residues [chemical binding]; other site 932677007703 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 932677007704 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932677007705 ABC-ATPase subunit interface; other site 932677007706 dimer interface [polypeptide binding]; other site 932677007707 putative PBP binding regions; other site 932677007708 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 932677007709 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 932677007710 Walker A/P-loop; other site 932677007711 ATP binding site [chemical binding]; other site 932677007712 Q-loop/lid; other site 932677007713 ABC transporter signature motif; other site 932677007714 Walker B; other site 932677007715 D-loop; other site 932677007716 H-loop/switch region; other site 932677007717 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932677007718 DNA binding site [nucleotide binding] 932677007719 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932677007720 magnesium-transporting ATPase; Provisional; Region: PRK15122 932677007721 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 932677007722 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 932677007723 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 932677007724 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677007725 motif II; other site 932677007726 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 932677007727 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 932677007728 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 932677007729 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 932677007730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677007731 dimer interface [polypeptide binding]; other site 932677007732 conserved gate region; other site 932677007733 putative PBP binding loops; other site 932677007734 ABC-ATPase subunit interface; other site 932677007735 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 932677007736 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 932677007737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677007738 dimer interface [polypeptide binding]; other site 932677007739 conserved gate region; other site 932677007740 ABC-ATPase subunit interface; other site 932677007741 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 932677007742 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932677007743 Walker A/P-loop; other site 932677007744 ATP binding site [chemical binding]; other site 932677007745 Q-loop/lid; other site 932677007746 ABC transporter signature motif; other site 932677007747 Walker B; other site 932677007748 D-loop; other site 932677007749 H-loop/switch region; other site 932677007750 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 932677007751 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932677007752 Walker A/P-loop; other site 932677007753 ATP binding site [chemical binding]; other site 932677007754 Q-loop/lid; other site 932677007755 ABC transporter signature motif; other site 932677007756 Walker B; other site 932677007757 D-loop; other site 932677007758 H-loop/switch region; other site 932677007759 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 932677007760 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677007761 Coenzyme A binding pocket [chemical binding]; other site 932677007762 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 932677007763 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 932677007764 S-methylmethionine transporter; Provisional; Region: PRK11387 932677007765 hypothetical protein; Provisional; Region: PRK10556 932677007766 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 932677007767 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 932677007768 catalytic residues [active] 932677007769 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 932677007770 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 932677007771 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 932677007772 Class I ribonucleotide reductase; Region: RNR_I; cd01679 932677007773 active site 932677007774 dimer interface [polypeptide binding]; other site 932677007775 catalytic residues [active] 932677007776 effector binding site; other site 932677007777 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 932677007778 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 932677007779 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 932677007780 dimer interface [polypeptide binding]; other site 932677007781 putative radical transfer pathway; other site 932677007782 diiron center [ion binding]; other site 932677007783 tyrosyl radical; other site 932677007784 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 932677007785 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 932677007786 Walker A/P-loop; other site 932677007787 ATP binding site [chemical binding]; other site 932677007788 Q-loop/lid; other site 932677007789 ABC transporter signature motif; other site 932677007790 Walker B; other site 932677007791 D-loop; other site 932677007792 H-loop/switch region; other site 932677007793 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 932677007794 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 932677007795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677007796 dimer interface [polypeptide binding]; other site 932677007797 conserved gate region; other site 932677007798 putative PBP binding loops; other site 932677007799 ABC-ATPase subunit interface; other site 932677007800 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 932677007801 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 932677007802 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 932677007803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677007804 potential protein location (hypothetical protein) that overlaps protein (facilitator family transporter YgaY) 932677007805 transcriptional repressor MprA; Provisional; Region: PRK10870 932677007806 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 932677007807 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 932677007808 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 932677007809 HlyD family secretion protein; Region: HlyD_3; pfam13437 932677007810 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 932677007811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677007812 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 932677007813 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 932677007814 putative NAD(P) binding site [chemical binding]; other site 932677007815 putative substrate binding site [chemical binding]; other site 932677007816 catalytic Zn binding site [ion binding]; other site 932677007817 structural Zn binding site [ion binding]; other site 932677007818 dimer interface [polypeptide binding]; other site 932677007819 Predicted transcriptional regulators [Transcription]; Region: COG1733 932677007820 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 932677007821 putative methyltransferase; Provisional; Region: PRK10864 932677007822 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 932677007823 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 932677007824 thioredoxin 2; Provisional; Region: PRK10996 932677007825 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 932677007826 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 932677007827 catalytic residues [active] 932677007828 Uncharacterized conserved protein [Function unknown]; Region: COG3148 932677007829 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 932677007830 CoA binding domain; Region: CoA_binding_2; pfam13380 932677007831 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 932677007832 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 932677007833 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 932677007834 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 932677007835 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 932677007836 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 932677007837 domain interface [polypeptide binding]; other site 932677007838 putative active site [active] 932677007839 catalytic site [active] 932677007840 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 932677007841 domain interface [polypeptide binding]; other site 932677007842 putative active site [active] 932677007843 catalytic site [active] 932677007844 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 932677007845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677007846 putative substrate translocation pore; other site 932677007847 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 932677007848 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 932677007849 putative NAD(P) binding site [chemical binding]; other site 932677007850 catalytic Zn binding site [ion binding]; other site 932677007851 structural Zn binding site [ion binding]; other site 932677007852 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 932677007853 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 932677007854 putative DNA binding site [nucleotide binding]; other site 932677007855 putative Zn2+ binding site [ion binding]; other site 932677007856 AsnC family; Region: AsnC_trans_reg; pfam01037 932677007857 protein disaggregation chaperone; Provisional; Region: PRK10865 932677007858 Clp amino terminal domain; Region: Clp_N; pfam02861 932677007859 Clp amino terminal domain; Region: Clp_N; pfam02861 932677007860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677007861 Walker A motif; other site 932677007862 ATP binding site [chemical binding]; other site 932677007863 Walker B motif; other site 932677007864 arginine finger; other site 932677007865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677007866 Walker A motif; other site 932677007867 ATP binding site [chemical binding]; other site 932677007868 Walker B motif; other site 932677007869 arginine finger; other site 932677007870 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 932677007871 potential protein location (hypothetical protein) that overlaps protein (chaperone ClpB) 932677007872 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 932677007873 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 932677007874 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 932677007875 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932677007876 RNA binding surface [nucleotide binding]; other site 932677007877 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 932677007878 active site 932677007879 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 932677007880 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 932677007881 30S subunit binding site; other site 932677007882 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 932677007883 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 932677007884 Prephenate dehydratase; Region: PDT; pfam00800 932677007885 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 932677007886 putative L-Phe binding site [chemical binding]; other site 932677007887 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 932677007888 Chorismate mutase type II; Region: CM_2; cl00693 932677007889 prephenate dehydrogenase; Validated; Region: PRK08507 932677007890 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 932677007891 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 932677007892 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 932677007893 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 932677007894 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 932677007895 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 932677007896 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 932677007897 RimM N-terminal domain; Region: RimM; pfam01782 932677007898 PRC-barrel domain; Region: PRC; pfam05239 932677007899 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 932677007900 signal recognition particle protein; Provisional; Region: PRK10867 932677007901 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 932677007902 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 932677007903 P loop; other site 932677007904 GTP binding site [chemical binding]; other site 932677007905 Signal peptide binding domain; Region: SRP_SPB; pfam02978 932677007906 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 932677007907 hypothetical protein; Provisional; Region: PRK11573 932677007908 Domain of unknown function DUF21; Region: DUF21; pfam01595 932677007909 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 932677007910 Transporter associated domain; Region: CorC_HlyC; smart01091 932677007911 S-ribosylhomocysteinase; Provisional; Region: PRK02260 932677007912 glutamate--cysteine ligase; Provisional; Region: PRK02107 932677007913 Predicted membrane protein [Function unknown]; Region: COG1238 932677007914 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 932677007915 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677007916 motif II; other site 932677007917 carbon storage regulator; Provisional; Region: PRK01712 932677007918 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 932677007919 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 932677007920 motif 1; other site 932677007921 active site 932677007922 motif 2; other site 932677007923 motif 3; other site 932677007924 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 932677007925 DHHA1 domain; Region: DHHA1; pfam02272 932677007926 recombination regulator RecX; Reviewed; Region: recX; PRK00117 932677007927 recombinase A; Provisional; Region: recA; PRK09354 932677007928 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 932677007929 hexamer interface [polypeptide binding]; other site 932677007930 Walker A motif; other site 932677007931 ATP binding site [chemical binding]; other site 932677007932 Walker B motif; other site 932677007933 hypothetical protein; Validated; Region: PRK03661 932677007934 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 932677007935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677007936 S-adenosylmethionine binding site [chemical binding]; other site 932677007937 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 932677007938 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 932677007939 PhnA protein; Region: PhnA; pfam03831 932677007940 Transglycosylase SLT domain; Region: SLT_2; pfam13406 932677007941 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 932677007942 N-acetyl-D-glucosamine binding site [chemical binding]; other site 932677007943 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 932677007944 MutS domain I; Region: MutS_I; pfam01624 932677007945 MutS domain II; Region: MutS_II; pfam05188 932677007946 MutS domain III; Region: MutS_III; pfam05192 932677007947 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 932677007948 Walker A/P-loop; other site 932677007949 ATP binding site [chemical binding]; other site 932677007950 Q-loop/lid; other site 932677007951 ABC transporter signature motif; other site 932677007952 Walker B; other site 932677007953 D-loop; other site 932677007954 H-loop/switch region; other site 932677007955 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 932677007956 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932677007957 non-specific DNA binding site [nucleotide binding]; other site 932677007958 salt bridge; other site 932677007959 sequence-specific DNA binding site [nucleotide binding]; other site 932677007960 2TM domain; Region: 2TM; pfam13239 932677007961 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 932677007962 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 932677007963 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 932677007964 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 932677007965 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 932677007966 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 932677007967 DNA binding residues [nucleotide binding] 932677007968 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932677007969 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 932677007970 Peptidase family M23; Region: Peptidase_M23; pfam01551 932677007971 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 932677007972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677007973 S-adenosylmethionine binding site [chemical binding]; other site 932677007974 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 932677007975 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 932677007976 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 932677007977 Permutation of conserved domain; other site 932677007978 active site 932677007979 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 932677007980 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 932677007981 homotrimer interaction site [polypeptide binding]; other site 932677007982 zinc binding site [ion binding]; other site 932677007983 CDP-binding sites; other site 932677007984 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 932677007985 substrate binding site; other site 932677007986 dimer interface; other site 932677007987 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 932677007988 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 932677007989 hypothetical protein; Provisional; Region: PRK10726 932677007990 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 932677007991 ligand-binding site [chemical binding]; other site 932677007992 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 932677007993 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 932677007994 CysD dimerization site [polypeptide binding]; other site 932677007995 G1 box; other site 932677007996 putative GEF interaction site [polypeptide binding]; other site 932677007997 GTP/Mg2+ binding site [chemical binding]; other site 932677007998 Switch I region; other site 932677007999 G2 box; other site 932677008000 G3 box; other site 932677008001 Switch II region; other site 932677008002 G4 box; other site 932677008003 G5 box; other site 932677008004 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 932677008005 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 932677008006 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 932677008007 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 932677008008 Active Sites [active] 932677008009 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 932677008010 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 932677008011 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 932677008012 active site 932677008013 SAM binding site [chemical binding]; other site 932677008014 homodimer interface [polypeptide binding]; other site 932677008015 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 932677008016 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 932677008017 metal binding site [ion binding]; metal-binding site 932677008018 Transcriptional regulator [Transcription]; Region: IclR; COG1414 932677008019 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 932677008020 Bacterial transcriptional regulator; Region: IclR; pfam01614 932677008021 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 932677008022 homotrimer interaction site [polypeptide binding]; other site 932677008023 putative active site [active] 932677008024 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 932677008025 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677008026 substrate binding pocket [chemical binding]; other site 932677008027 membrane-bound complex binding site; other site 932677008028 hinge residues; other site 932677008029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677008030 dimer interface [polypeptide binding]; other site 932677008031 conserved gate region; other site 932677008032 putative PBP binding loops; other site 932677008033 ABC-ATPase subunit interface; other site 932677008034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677008035 dimer interface [polypeptide binding]; other site 932677008036 conserved gate region; other site 932677008037 putative PBP binding loops; other site 932677008038 ABC-ATPase subunit interface; other site 932677008039 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 932677008040 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 932677008041 Walker A/P-loop; other site 932677008042 ATP binding site [chemical binding]; other site 932677008043 Q-loop/lid; other site 932677008044 ABC transporter signature motif; other site 932677008045 Walker B; other site 932677008046 D-loop; other site 932677008047 H-loop/switch region; other site 932677008048 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 932677008049 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 932677008050 active site 932677008051 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 932677008052 dimer interface [polypeptide binding]; other site 932677008053 substrate binding site [chemical binding]; other site 932677008054 catalytic residue [active] 932677008055 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 932677008056 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 932677008057 Active Sites [active] 932677008058 sulfite reductase subunit beta; Provisional; Region: PRK13504 932677008059 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 932677008060 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 932677008061 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 932677008062 Flavodoxin; Region: Flavodoxin_1; pfam00258 932677008063 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 932677008064 FAD binding pocket [chemical binding]; other site 932677008065 FAD binding motif [chemical binding]; other site 932677008066 catalytic residues [active] 932677008067 NAD binding pocket [chemical binding]; other site 932677008068 phosphate binding motif [ion binding]; other site 932677008069 beta-alpha-beta structure motif; other site 932677008070 N-acetyltransferase; Region: Acetyltransf_2; cl00949 932677008071 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 932677008072 active site 932677008073 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 932677008074 dimer interface [polypeptide binding]; other site 932677008075 substrate binding site [chemical binding]; other site 932677008076 metal binding sites [ion binding]; metal-binding site 932677008077 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 932677008078 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 932677008079 Nucleoside recognition; Region: Gate; pfam07670 932677008080 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 932677008081 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 932677008082 putative catalytic site [active] 932677008083 putative phosphate binding site [ion binding]; other site 932677008084 putative metal binding site [ion binding]; other site 932677008085 enolase; Provisional; Region: eno; PRK00077 932677008086 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 932677008087 dimer interface [polypeptide binding]; other site 932677008088 metal binding site [ion binding]; metal-binding site 932677008089 substrate binding pocket [chemical binding]; other site 932677008090 CTP synthetase; Validated; Region: pyrG; PRK05380 932677008091 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 932677008092 Catalytic site [active] 932677008093 active site 932677008094 UTP binding site [chemical binding]; other site 932677008095 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 932677008096 active site 932677008097 putative oxyanion hole; other site 932677008098 catalytic triad [active] 932677008099 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 932677008100 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 932677008101 homodimer interface [polypeptide binding]; other site 932677008102 metal binding site [ion binding]; metal-binding site 932677008103 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 932677008104 homodimer interface [polypeptide binding]; other site 932677008105 active site 932677008106 putative chemical substrate binding site [chemical binding]; other site 932677008107 metal binding site [ion binding]; metal-binding site 932677008108 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 932677008109 HD domain; Region: HD_4; pfam13328 932677008110 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 932677008111 synthetase active site [active] 932677008112 NTP binding site [chemical binding]; other site 932677008113 metal binding site [ion binding]; metal-binding site 932677008114 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 932677008115 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 932677008116 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 932677008117 TRAM domain; Region: TRAM; pfam01938 932677008118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677008119 S-adenosylmethionine binding site [chemical binding]; other site 932677008120 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 932677008121 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 932677008122 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932677008123 dimerization interface [polypeptide binding]; other site 932677008124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932677008125 dimer interface [polypeptide binding]; other site 932677008126 phosphorylation site [posttranslational modification] 932677008127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677008128 ATP binding site [chemical binding]; other site 932677008129 Mg2+ binding site [ion binding]; other site 932677008130 G-X-G motif; other site 932677008131 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 932677008132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677008133 active site 932677008134 phosphorylation site [posttranslational modification] 932677008135 intermolecular recognition site; other site 932677008136 dimerization interface [polypeptide binding]; other site 932677008137 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 932677008138 putative binding surface; other site 932677008139 active site 932677008140 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 932677008141 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 932677008142 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 932677008143 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 932677008144 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 932677008145 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 932677008146 active site 932677008147 tetramer interface [polypeptide binding]; other site 932677008148 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 932677008149 metal binding site [ion binding]; metal-binding site 932677008150 substrate binding pocket [chemical binding]; other site 932677008151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677008152 D-galactonate transporter; Region: 2A0114; TIGR00893 932677008153 putative substrate translocation pore; other site 932677008154 galactarate dehydratase; Region: galactar-dH20; TIGR03248 932677008155 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 932677008156 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 932677008157 potential protein location (hypothetical protein) that overlaps protein (D-galactarate dehydratase GarD) 932677008158 flavodoxin; Provisional; Region: PRK08105 932677008159 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 932677008160 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 932677008161 probable active site [active] 932677008162 tRNA pseudouridine synthase C; Region: DUF446; cl01187 932677008163 SecY interacting protein Syd; Provisional; Region: PRK04968 932677008164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 932677008165 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 932677008166 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 932677008167 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 932677008168 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 932677008169 flap endonuclease-like protein; Provisional; Region: PRK09482 932677008170 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 932677008171 active site 932677008172 metal binding site 1 [ion binding]; metal-binding site 932677008173 putative 5' ssDNA interaction site; other site 932677008174 metal binding site 3; metal-binding site 932677008175 metal binding site 2 [ion binding]; metal-binding site 932677008176 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 932677008177 putative DNA binding site [nucleotide binding]; other site 932677008178 putative metal binding site [ion binding]; other site 932677008179 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 932677008180 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 932677008181 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 932677008182 hypothetical protein; Provisional; Region: PRK10873 932677008183 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 932677008184 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677008185 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 932677008186 dimerization interface [polypeptide binding]; other site 932677008187 substrate binding pocket [chemical binding]; other site 932677008188 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 932677008189 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 932677008190 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 932677008191 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932677008192 catalytic residue [active] 932677008193 cysteine desulfurase, sulfur acceptor subunit CsdE; Region: FeS_syn_CsdE; TIGR03391 932677008194 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 932677008195 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 932677008196 putative ATP binding site [chemical binding]; other site 932677008197 putative substrate interface [chemical binding]; other site 932677008198 murein transglycosylase A; Provisional; Region: mltA; PRK11162 932677008199 MltA specific insert domain; Region: MltA; smart00925 932677008200 3D domain; Region: 3D; pfam06725 932677008201 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 932677008202 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 932677008203 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932677008204 catalytic residue [active] 932677008205 AMIN domain; Region: AMIN; pfam11741 932677008206 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 932677008207 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 932677008208 active site 932677008209 metal binding site [ion binding]; metal-binding site 932677008210 N-acetylglutamate synthase; Validated; Region: PRK05279 932677008211 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 932677008212 putative nucleotide binding site [chemical binding]; other site 932677008213 putative substrate binding site [chemical binding]; other site 932677008214 N-acetylglutamate synthase and related acetyltransferases [Amino acid transport and metabolism]; Region: ArgA; COG1246 932677008215 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 932677008216 AAA domain; Region: AAA_30; pfam13604 932677008217 Family description; Region: UvrD_C_2; pfam13538 932677008218 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 932677008219 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 932677008220 protease3; Provisional; Region: PRK15101 932677008221 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 932677008222 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 932677008223 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 932677008224 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 932677008225 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 932677008226 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 932677008227 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 932677008228 hypothetical protein; Provisional; Region: PRK10557 932677008229 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 932677008230 hypothetical protein; Provisional; Region: PRK10506 932677008231 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 932677008232 thymidylate synthase; Reviewed; Region: thyA; PRK01827 932677008233 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 932677008234 dimerization interface [polypeptide binding]; other site 932677008235 active site 932677008236 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 932677008237 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 932677008238 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 932677008239 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 932677008240 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 932677008241 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 932677008242 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 932677008243 putative active site [active] 932677008244 Ap4A binding site [chemical binding]; other site 932677008245 nudix motif; other site 932677008246 putative metal binding site [ion binding]; other site 932677008247 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 932677008248 putative DNA-binding cleft [nucleotide binding]; other site 932677008249 putative DNA clevage site; other site 932677008250 molecular lever; other site 932677008251 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 932677008252 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 932677008253 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932677008254 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932677008255 active site 932677008256 catalytic tetrad [active] 932677008257 diaminopimelate decarboxylase; Provisional; Region: PRK11165 932677008258 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 932677008259 active site 932677008260 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 932677008261 substrate binding site [chemical binding]; other site 932677008262 catalytic residues [active] 932677008263 dimer interface [polypeptide binding]; other site 932677008264 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 932677008265 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677008266 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 932677008267 dimerization interface [polypeptide binding]; other site 932677008268 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 932677008269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677008270 putative substrate translocation pore; other site 932677008271 Cupin domain; Region: Cupin_2; cl17218 932677008272 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 932677008273 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 932677008274 dimer interface [polypeptide binding]; other site 932677008275 putative anticodon binding site; other site 932677008276 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 932677008277 motif 1; other site 932677008278 active site 932677008279 motif 2; other site 932677008280 motif 3; other site 932677008281 peptide chain release factor 2; Provisional; Region: PRK08787 932677008282 This domain is found in peptide chain release factors; Region: PCRF; smart00937 932677008283 RF-1 domain; Region: RF-1; pfam00472 932677008284 Single-stranded DNA-specific exonuclease [DNA replication, recombination, and repair]; Region: RecJ; COG0608 932677008285 DHH family; Region: DHH; pfam01368 932677008286 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 932677008287 active site 932677008288 DHHA1 domain; Region: DHHA1; pfam02272 932677008289 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 932677008290 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 932677008291 dimerization domain [polypeptide binding]; other site 932677008292 dimer interface [polypeptide binding]; other site 932677008293 catalytic residues [active] 932677008294 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 932677008295 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 932677008296 active site 932677008297 DNA binding site [nucleotide binding] 932677008298 Int/Topo IB signature motif; other site 932677008299 flavodoxin FldB; Provisional; Region: PRK12359 932677008300 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 932677008301 hypothetical protein; Provisional; Region: PRK10878 932677008302 putative global regulator; Reviewed; Region: PRK09559 932677008303 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 932677008304 hemolysin; Provisional; Region: PRK15087 932677008305 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 932677008306 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 932677008307 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932677008308 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932677008309 putative active site [active] 932677008310 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 932677008311 beta-galactosidase; Region: BGL; TIGR03356 932677008312 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 932677008313 classical (c) SDRs; Region: SDR_c; cd05233 932677008314 NAD(P) binding site [chemical binding]; other site 932677008315 active site 932677008316 glycine dehydrogenase; Provisional; Region: PRK05367 932677008317 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 932677008318 tetramer interface [polypeptide binding]; other site 932677008319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677008320 catalytic residue [active] 932677008321 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 932677008322 tetramer interface [polypeptide binding]; other site 932677008323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677008324 catalytic residue [active] 932677008325 glycine cleavage system protein H; Provisional; Region: PRK13380 932677008326 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 932677008327 lipoyl attachment site [posttranslational modification]; other site 932677008328 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 932677008329 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 932677008330 oxidoreductase; Provisional; Region: PRK08013 932677008331 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 932677008332 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 932677008333 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 932677008334 proline aminopeptidase P II; Provisional; Region: PRK10879 932677008335 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 932677008336 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 932677008337 active site 932677008338 hypothetical protein; Reviewed; Region: PRK01736 932677008339 Z-ring-associated protein; Provisional; Region: PRK10972 932677008340 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 932677008341 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 932677008342 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 932677008343 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 932677008344 ligand binding site [chemical binding]; other site 932677008345 NAD binding site [chemical binding]; other site 932677008346 tetramer interface [polypeptide binding]; other site 932677008347 catalytic site [active] 932677008348 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 932677008349 L-serine binding site [chemical binding]; other site 932677008350 ACT domain interface; other site 932677008351 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 932677008352 tetramer (dimer of dimers) interface [polypeptide binding]; other site 932677008353 active site 932677008354 dimer interface [polypeptide binding]; other site 932677008355 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 932677008356 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677008357 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 932677008358 putative dimerization interface [polypeptide binding]; other site 932677008359 oxidative stress defense protein; Provisional; Region: PRK11087 932677008360 Uncharacterized conserved protein [Function unknown]; Region: COG2968 932677008361 LysE type translocator; Region: LysE; cl00565 932677008362 mechanosensitive channel MscS; Provisional; Region: PRK10334 932677008363 Mechanosensitive ion channel; Region: MS_channel; pfam00924 932677008364 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 932677008365 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 932677008366 active site 932677008367 intersubunit interface [polypeptide binding]; other site 932677008368 zinc binding site [ion binding]; other site 932677008369 Na+ binding site [ion binding]; other site 932677008370 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 932677008371 Phosphoglycerate kinase; Region: PGK; pfam00162 932677008372 substrate binding site [chemical binding]; other site 932677008373 hinge regions; other site 932677008374 ADP binding site [chemical binding]; other site 932677008375 catalytic site [active] 932677008376 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 932677008377 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 932677008378 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 932677008379 transketolase; Reviewed; Region: PRK12753 932677008380 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 932677008381 TPP-binding site [chemical binding]; other site 932677008382 dimer interface [polypeptide binding]; other site 932677008383 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 932677008384 PYR/PP interface [polypeptide binding]; other site 932677008385 dimer interface [polypeptide binding]; other site 932677008386 TPP binding site [chemical binding]; other site 932677008387 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 932677008388 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 932677008389 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 932677008390 agmatinase; Region: agmatinase; TIGR01230 932677008391 oligomer interface [polypeptide binding]; other site 932677008392 putative active site [active] 932677008393 Mn binding site [ion binding]; other site 932677008394 arginine decarboxylase; Provisional; Region: PRK05354 932677008395 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 932677008396 dimer interface [polypeptide binding]; other site 932677008397 active site 932677008398 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 932677008399 catalytic residues [active] 932677008400 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 932677008401 S-adenosylmethionine synthetase; Validated; Region: PRK05250 932677008402 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 932677008403 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 932677008404 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 932677008405 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 932677008406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677008407 putative substrate translocation pore; other site 932677008408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677008409 Cache domain; Region: Cache_1; pfam02743 932677008410 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 932677008411 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677008412 dimer interface [polypeptide binding]; other site 932677008413 putative CheW interface [polypeptide binding]; other site 932677008414 hypothetical protein; Provisional; Region: PRK04860 932677008415 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 932677008416 DNA-specific endonuclease I; Provisional; Region: PRK15137 932677008417 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 932677008418 potential protein location (hypothetical protein) that overlaps protein (nuclease NucM precursor) 932677008419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 932677008420 RNA methyltransferase, RsmE family; Region: TIGR00046 932677008421 glutathione synthetase; Provisional; Region: PRK05246 932677008422 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 932677008423 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 932677008424 hypothetical protein; Validated; Region: PRK00228 932677008425 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 932677008426 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 932677008427 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 932677008428 Walker A motif; other site 932677008429 ATP binding site [chemical binding]; other site 932677008430 Walker B motif; other site 932677008431 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 932677008432 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 932677008433 catalytic residue [active] 932677008434 YGGT family; Region: YGGT; pfam02325 932677008435 Predicted integral membrane protein [Function unknown]; Region: COG0762 932677008436 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 932677008437 active site 932677008438 dimerization interface [polypeptide binding]; other site 932677008439 HemN family oxidoreductase; Provisional; Region: PRK05660 932677008440 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 932677008441 FeS/SAM binding site; other site 932677008442 HemN C-terminal domain; Region: HemN_C; pfam06969 932677008443 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 932677008444 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932677008445 DNA-binding site [nucleotide binding]; DNA binding site 932677008446 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 932677008447 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932677008448 active site 932677008449 phosphorylation site [posttranslational modification] 932677008450 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 932677008451 hypothetical protein; Provisional; Region: PRK10626 932677008452 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 932677008453 hypothetical protein; Provisional; Region: PRK11702 932677008454 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 932677008455 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 932677008456 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677008457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677008458 alpha-galactosidase; Provisional; Region: PRK15076 932677008459 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 932677008460 NAD binding site [chemical binding]; other site 932677008461 sugar binding site [chemical binding]; other site 932677008462 divalent metal binding site [ion binding]; other site 932677008463 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 932677008464 dimer interface [polypeptide binding]; other site 932677008465 melibiose:sodium symporter; Provisional; Region: PRK10429 932677008466 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 932677008467 adenine DNA glycosylase; Provisional; Region: PRK10880 932677008468 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 932677008469 minor groove reading motif; other site 932677008470 helix-hairpin-helix signature motif; other site 932677008471 substrate binding pocket [chemical binding]; other site 932677008472 active site 932677008473 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 932677008474 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 932677008475 DNA binding and oxoG recognition site [nucleotide binding] 932677008476 oxidative damage protection protein; Provisional; Region: PRK05408 932677008477 murein transglycosylase C; Provisional; Region: mltC; PRK11671 932677008478 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 932677008479 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 932677008480 N-acetyl-D-glucosamine binding site [chemical binding]; other site 932677008481 catalytic residue [active] 932677008482 ornithine decarboxylase; Provisional; Region: PRK13578 932677008483 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 932677008484 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 932677008485 homodimer interface [polypeptide binding]; other site 932677008486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677008487 catalytic residue [active] 932677008488 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 932677008489 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 932677008490 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 932677008491 NADP binding site [chemical binding]; other site 932677008492 dimer interface [polypeptide binding]; other site 932677008493 Predicted transcriptional regulators [Transcription]; Region: COG1695 932677008494 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 932677008495 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 932677008496 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 932677008497 FAD binding pocket [chemical binding]; other site 932677008498 FAD binding motif [chemical binding]; other site 932677008499 phosphate binding motif [ion binding]; other site 932677008500 NAD binding pocket [chemical binding]; other site 932677008501 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 932677008502 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677008503 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 932677008504 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 932677008505 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 932677008506 Predicted transcriptional regulators [Transcription]; Region: COG1733 932677008507 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 932677008508 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 932677008509 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 932677008510 NADP binding site [chemical binding]; other site 932677008511 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932677008512 putative DNA binding site [nucleotide binding]; other site 932677008513 dimerization interface [polypeptide binding]; other site 932677008514 putative Zn2+ binding site [ion binding]; other site 932677008515 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 932677008516 trehalase; Provisional; Region: treF; PRK13270 932677008517 Trehalase; Region: Trehalase; cl17346 932677008518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 932677008519 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 932677008520 dimerization interface [polypeptide binding]; other site 932677008521 metal binding site [ion binding]; metal-binding site 932677008522 General stress protein [General function prediction only]; Region: GsiB; COG3729 932677008523 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 932677008524 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 932677008525 TAP-like protein; Region: Abhydrolase_4; pfam08386 932677008526 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932677008527 putative active site [active] 932677008528 PAS fold; Region: PAS_3; pfam08447 932677008529 heme pocket [chemical binding]; other site 932677008530 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932677008531 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932677008532 metal binding site [ion binding]; metal-binding site 932677008533 active site 932677008534 I-site; other site 932677008535 hypothetical protein; Provisional; Region: PRK10316 932677008536 YfdX protein; Region: YfdX; pfam10938 932677008537 CHASE3 domain; Region: CHASE3; pfam05227 932677008538 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 932677008539 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677008540 dimer interface [polypeptide binding]; other site 932677008541 putative CheW interface [polypeptide binding]; other site 932677008542 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932677008543 PAS domain; Region: PAS_9; pfam13426 932677008544 putative active site [active] 932677008545 heme pocket [chemical binding]; other site 932677008546 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932677008547 PAS domain; Region: PAS_9; pfam13426 932677008548 putative active site [active] 932677008549 heme pocket [chemical binding]; other site 932677008550 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 932677008551 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677008552 dimer interface [polypeptide binding]; other site 932677008553 putative CheW interface [polypeptide binding]; other site 932677008554 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932677008555 PAS domain; Region: PAS_9; pfam13426 932677008556 putative active site [active] 932677008557 heme pocket [chemical binding]; other site 932677008558 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932677008559 PAS domain; Region: PAS_9; pfam13426 932677008560 putative active site [active] 932677008561 heme pocket [chemical binding]; other site 932677008562 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 932677008563 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677008564 dimer interface [polypeptide binding]; other site 932677008565 putative CheW interface [polypeptide binding]; other site 932677008566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 932677008567 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 932677008568 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 932677008569 active site 932677008570 catalytic residues [active] 932677008571 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 932677008572 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 932677008573 Predicted transcriptional regulators [Transcription]; Region: COG1733 932677008574 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 932677008575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677008576 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932677008577 putative substrate translocation pore; other site 932677008578 EamA-like transporter family; Region: EamA; pfam00892 932677008579 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 932677008580 EamA-like transporter family; Region: EamA; pfam00892 932677008581 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677008582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677008583 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 932677008584 dimerization interface [polypeptide binding]; other site 932677008585 hypothetical protein; Provisional; Region: PRK07079 932677008586 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 932677008587 metal binding site [ion binding]; metal-binding site 932677008588 putative dimer interface [polypeptide binding]; other site 932677008589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677008590 metabolite-proton symporter; Region: 2A0106; TIGR00883 932677008591 putative substrate translocation pore; other site 932677008592 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 932677008593 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 932677008594 Transposase; Region: DEDD_Tnp_IS110; pfam01548 932677008595 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 932677008596 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 932677008597 structural tetrad; other site 932677008598 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 932677008599 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 932677008600 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 932677008601 gating phenylalanine in ion channel; other site 932677008602 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 932677008603 ligand binding site [chemical binding]; other site 932677008604 active site 932677008605 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 932677008606 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 932677008607 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 932677008608 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 932677008609 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 932677008610 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 932677008611 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 932677008612 CHAT domain; Region: CHAT; cl17868 932677008613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 932677008614 ATP binding site [chemical binding]; other site 932677008615 Mg2+ binding site [ion binding]; other site 932677008616 G-X-G motif; other site 932677008617 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 932677008618 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 932677008619 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 932677008620 Integrase; Region: Integrase_1; pfam12835 932677008621 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 932677008622 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 932677008623 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 932677008624 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 932677008625 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 932677008626 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 932677008627 methionine S-methyltransferase; Region: PLN02672 932677008628 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 932677008629 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 932677008630 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 932677008631 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932677008632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677008633 putative substrate translocation pore; other site 932677008634 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 932677008635 active site 932677008636 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 932677008637 dimer interface [polypeptide binding]; other site 932677008638 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 932677008639 Ligand Binding Site [chemical binding]; other site 932677008640 Molecular Tunnel; other site 932677008641 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 932677008642 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 932677008643 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 932677008644 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 932677008645 PYR/PP interface [polypeptide binding]; other site 932677008646 dimer interface [polypeptide binding]; other site 932677008647 TPP binding site [chemical binding]; other site 932677008648 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 932677008649 TPP-binding site [chemical binding]; other site 932677008650 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 932677008651 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 932677008652 tetramer interface [polypeptide binding]; other site 932677008653 active site 932677008654 Mg2+/Mn2+ binding site [ion binding]; other site 932677008655 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 932677008656 Catalytic site [active] 932677008657 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 932677008658 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 932677008659 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 932677008660 active site 932677008661 catalytic residues [active] 932677008662 DNA binding site [nucleotide binding] 932677008663 Int/Topo IB signature motif; other site 932677008664 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932677008665 catalytic core [active] 932677008666 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932677008667 enolase; Provisional; Region: eno; PRK00077 932677008668 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 932677008669 dimer interface [polypeptide binding]; other site 932677008670 metal binding site [ion binding]; metal-binding site 932677008671 substrate binding pocket [chemical binding]; other site 932677008672 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 932677008673 DHHA2 domain; Region: DHHA2; pfam02833 932677008674 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 932677008675 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 932677008676 gating phenylalanine in ion channel; other site 932677008677 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 932677008678 structural tetrad; other site 932677008679 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 932677008680 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 932677008681 DNA binding site [nucleotide binding] 932677008682 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 932677008683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677008684 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 932677008685 Coenzyme A binding pocket [chemical binding]; other site 932677008686 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 932677008687 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932677008688 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932677008689 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 932677008690 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 932677008691 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 932677008692 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 932677008693 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 932677008694 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 932677008695 active site 932677008696 catalytic residues [active] 932677008697 DNA binding site [nucleotide binding] 932677008698 Int/Topo IB signature motif; other site 932677008699 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 932677008700 FOG: CBS domain [General function prediction only]; Region: COG0517 932677008701 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 932677008702 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 932677008703 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932677008704 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932677008705 metal binding site [ion binding]; metal-binding site 932677008706 active site 932677008707 I-site; other site 932677008708 penicillin-binding protein 2; Provisional; Region: PRK10795 932677008709 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 932677008710 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 932677008711 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 932677008712 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 932677008713 phosphopentomutase; Provisional; Region: PRK05362 932677008714 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 932677008715 thymidine phosphorylase; Region: T_phosphoryl; TIGR02643 932677008716 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 932677008717 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 932677008718 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 932677008719 intersubunit interface [polypeptide binding]; other site 932677008720 active site 932677008721 catalytic residue [active] 932677008722 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 932677008723 active site 932677008724 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 932677008725 periplasmic protein; Provisional; Region: PRK10568 932677008726 BON domain; Region: BON; cl02771 932677008727 BON domain; Region: BON; pfam04972 932677008728 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 932677008729 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 932677008730 G1 box; other site 932677008731 putative GEF interaction site [polypeptide binding]; other site 932677008732 GTP/Mg2+ binding site [chemical binding]; other site 932677008733 Switch I region; other site 932677008734 G2 box; other site 932677008735 G3 box; other site 932677008736 Switch II region; other site 932677008737 G4 box; other site 932677008738 G5 box; other site 932677008739 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 932677008740 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 932677008741 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 932677008742 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 932677008743 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 932677008744 Ferritin-like domain; Region: Ferritin; pfam00210 932677008745 ferroxidase diiron center [ion binding]; other site 932677008746 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 932677008747 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 932677008748 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 932677008749 putative active site [active] 932677008750 putative catalytic site [active] 932677008751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677008752 D-galactonate transporter; Region: 2A0114; TIGR00893 932677008753 putative substrate translocation pore; other site 932677008754 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932677008755 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932677008756 DNA binding site [nucleotide binding] 932677008757 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 932677008758 ligand binding site [chemical binding]; other site 932677008759 dimerization interface [polypeptide binding]; other site 932677008760 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 932677008761 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 932677008762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677008763 dimer interface [polypeptide binding]; other site 932677008764 conserved gate region; other site 932677008765 putative PBP binding loops; other site 932677008766 ABC-ATPase subunit interface; other site 932677008767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677008768 dimer interface [polypeptide binding]; other site 932677008769 conserved gate region; other site 932677008770 putative PBP binding loops; other site 932677008771 ABC-ATPase subunit interface; other site 932677008772 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 932677008773 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 932677008774 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 932677008775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677008776 Walker A/P-loop; other site 932677008777 ATP binding site [chemical binding]; other site 932677008778 Q-loop/lid; other site 932677008779 ABC transporter signature motif; other site 932677008780 Walker B; other site 932677008781 D-loop; other site 932677008782 H-loop/switch region; other site 932677008783 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 932677008784 putative acyl-acceptor binding pocket; other site 932677008785 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 932677008786 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 932677008787 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677008788 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 932677008789 substrate binding pocket [chemical binding]; other site 932677008790 membrane-bound complex binding site; other site 932677008791 hinge residues; other site 932677008792 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 932677008793 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 932677008794 Walker A/P-loop; other site 932677008795 ATP binding site [chemical binding]; other site 932677008796 Q-loop/lid; other site 932677008797 ABC transporter signature motif; other site 932677008798 Walker B; other site 932677008799 D-loop; other site 932677008800 H-loop/switch region; other site 932677008801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677008802 dimer interface [polypeptide binding]; other site 932677008803 conserved gate region; other site 932677008804 putative PBP binding loops; other site 932677008805 ABC-ATPase subunit interface; other site 932677008806 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 932677008807 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677008808 Coenzyme A binding pocket [chemical binding]; other site 932677008809 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 932677008810 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677008811 substrate binding pocket [chemical binding]; other site 932677008812 membrane-bound complex binding site; other site 932677008813 hinge residues; other site 932677008814 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 932677008815 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 932677008816 active site 932677008817 non-prolyl cis peptide bond; other site 932677008818 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 932677008819 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 932677008820 metal binding site [ion binding]; metal-binding site 932677008821 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 932677008822 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 932677008823 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 932677008824 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 932677008825 metal binding site [ion binding]; metal-binding site 932677008826 dimer interface [polypeptide binding]; other site 932677008827 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 932677008828 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 932677008829 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 932677008830 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 932677008831 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 932677008832 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932677008833 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932677008834 metal binding site [ion binding]; metal-binding site 932677008835 active site 932677008836 I-site; other site 932677008837 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932677008838 Spore Coat Protein U domain; Region: SCPU; pfam05229 932677008839 Spore Coat Protein U domain; Region: SCPU; pfam05229 932677008840 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 932677008841 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 932677008842 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 932677008843 PapC N-terminal domain; Region: PapC_N; pfam13954 932677008844 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 932677008845 PapC C-terminal domain; Region: PapC_C; pfam13953 932677008846 Spore Coat Protein U domain; Region: SCPU; cl02253 932677008847 Spore Coat Protein U domain; Region: SCPU; pfam05229 932677008848 citrate-proton symporter; Provisional; Region: PRK15075 932677008849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677008850 putative substrate translocation pore; other site 932677008851 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 932677008852 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 932677008853 biopolymer transport protein ExbB; Provisional; Region: PRK10414 932677008854 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 932677008855 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 932677008856 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 932677008857 active site turn [active] 932677008858 phosphorylation site [posttranslational modification] 932677008859 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 932677008860 benzoate transport; Region: 2A0115; TIGR00895 932677008861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677008862 putative substrate translocation pore; other site 932677008863 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 932677008864 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 932677008865 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 932677008866 dimer interface [polypeptide binding]; other site 932677008867 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 932677008868 active site 932677008869 Fe binding site [ion binding]; other site 932677008870 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 932677008871 heterodimer interface [polypeptide binding]; other site 932677008872 multimer interface [polypeptide binding]; other site 932677008873 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 932677008874 active site 932677008875 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 932677008876 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 932677008877 heterodimer interface [polypeptide binding]; other site 932677008878 active site 932677008879 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 932677008880 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677008881 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 932677008882 dimerization interface [polypeptide binding]; other site 932677008883 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 932677008884 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 932677008885 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 932677008886 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 932677008887 tetramer interface [polypeptide binding]; other site 932677008888 active site 932677008889 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 932677008890 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 932677008891 dimer interface [polypeptide binding]; other site 932677008892 active site 932677008893 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 932677008894 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 932677008895 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 932677008896 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 932677008897 Bacterial transcriptional regulator; Region: IclR; pfam01614 932677008898 cystathionine beta-lyase; Provisional; Region: PRK08114 932677008899 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 932677008900 homodimer interface [polypeptide binding]; other site 932677008901 substrate-cofactor binding pocket; other site 932677008902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677008903 catalytic residue [active] 932677008904 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 932677008905 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 932677008906 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 932677008907 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 932677008908 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677008909 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677008910 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932677008911 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932677008912 active site 932677008913 catalytic tetrad [active] 932677008914 flagellin; Provisional; Region: PRK12802 932677008915 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 932677008916 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 932677008917 FtsI repressor; Provisional; Region: PRK10883 932677008918 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 932677008919 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 932677008920 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 932677008921 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 932677008922 putative acyl-acceptor binding pocket; other site 932677008923 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 932677008924 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 932677008925 CAP-like domain; other site 932677008926 active site 932677008927 primary dimer interface [polypeptide binding]; other site 932677008928 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 932677008929 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932677008930 PRD domain; Region: PRD; pfam00874 932677008931 PRD domain; Region: PRD; pfam00874 932677008932 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932677008933 active site 932677008934 P-loop; other site 932677008935 phosphorylation site [posttranslational modification] 932677008936 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932677008937 active site 932677008938 phosphorylation site [posttranslational modification] 932677008939 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 932677008940 active site 932677008941 P-loop; other site 932677008942 phosphorylation site [posttranslational modification] 932677008943 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 932677008944 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 932677008945 intersubunit interface [polypeptide binding]; other site 932677008946 active site 932677008947 zinc binding site [ion binding]; other site 932677008948 Na+ binding site [ion binding]; other site 932677008949 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 932677008950 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677008951 substrate binding pocket [chemical binding]; other site 932677008952 membrane-bound complex binding site; other site 932677008953 hinge residues; other site 932677008954 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 932677008955 Uncharacterized conserved protein [Function unknown]; Region: COG1359 932677008956 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 932677008957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677008958 ATP binding site [chemical binding]; other site 932677008959 Mg2+ binding site [ion binding]; other site 932677008960 G-X-G motif; other site 932677008961 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 932677008962 anchoring element; other site 932677008963 dimer interface [polypeptide binding]; other site 932677008964 ATP binding site [chemical binding]; other site 932677008965 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 932677008966 active site 932677008967 metal binding site [ion binding]; metal-binding site 932677008968 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 932677008969 esterase YqiA; Provisional; Region: PRK11071 932677008970 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 932677008971 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 932677008972 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 932677008973 hexamer interface [polypeptide binding]; other site 932677008974 putative dehydrogenase; Provisional; Region: PRK11039 932677008975 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 932677008976 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 932677008977 dimer interface [polypeptide binding]; other site 932677008978 ADP-ribose binding site [chemical binding]; other site 932677008979 active site 932677008980 nudix motif; other site 932677008981 metal binding site [ion binding]; metal-binding site 932677008982 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 932677008983 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 932677008984 hypothetical protein; Provisional; Region: PRK11653 932677008985 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 932677008986 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 932677008987 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 932677008988 putative active site [active] 932677008989 metal binding site [ion binding]; metal-binding site 932677008990 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 932677008991 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 932677008992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 932677008993 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 932677008994 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 932677008995 putative ribose interaction site [chemical binding]; other site 932677008996 putative ADP binding site [chemical binding]; other site 932677008997 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 932677008998 active site 932677008999 nucleotide binding site [chemical binding]; other site 932677009000 HIGH motif; other site 932677009001 KMSKS motif; other site 932677009002 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 932677009003 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 932677009004 metal binding triad; other site 932677009005 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 932677009006 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 932677009007 metal binding triad; other site 932677009008 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 932677009009 Uncharacterized conserved protein [Function unknown]; Region: COG3025 932677009010 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 932677009011 putative active site [active] 932677009012 putative metal binding residues [ion binding]; other site 932677009013 signature motif; other site 932677009014 putative triphosphate binding site [ion binding]; other site 932677009015 SH3 domain-containing protein; Provisional; Region: PRK10884 932677009016 Bacterial SH3 domain homologues; Region: SH3b; smart00287 932677009017 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 932677009018 Poly A polymerase head domain; Region: PolyA_pol; pfam01743 932677009019 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 932677009020 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932677009021 Zn2+ binding site [ion binding]; other site 932677009022 Mg2+ binding site [ion binding]; other site 932677009023 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 932677009024 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 932677009025 homooctamer interface [polypeptide binding]; other site 932677009026 active site 932677009027 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 932677009028 UGMP family protein; Validated; Region: PRK09604 932677009029 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 932677009030 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 932677009031 DNA primase; Validated; Region: dnaG; PRK05667 932677009032 CHC2 zinc finger; Region: zf-CHC2; pfam01807 932677009033 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 932677009034 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 932677009035 active site 932677009036 metal binding site [ion binding]; metal-binding site 932677009037 interdomain interaction site; other site 932677009038 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 932677009039 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 932677009040 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 932677009041 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 932677009042 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 932677009043 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 932677009044 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 932677009045 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 932677009046 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 932677009047 DNA binding residues [nucleotide binding] 932677009048 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 932677009049 active site 932677009050 SUMO-1 interface [polypeptide binding]; other site 932677009051 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 932677009052 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 932677009053 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 932677009054 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 932677009055 Phage tail tube protein FII; Region: Phage_tube; cl01390 932677009056 major tail sheath protein; Provisional; Region: FI; PHA02560 932677009057 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 932677009058 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 932677009059 catalytic residues [active] 932677009060 catalytic nucleophile [active] 932677009061 Presynaptic Site I dimer interface [polypeptide binding]; other site 932677009062 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 932677009063 Synaptic Flat tetramer interface [polypeptide binding]; other site 932677009064 Synaptic Site I dimer interface [polypeptide binding]; other site 932677009065 DNA binding site [nucleotide binding] 932677009066 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 932677009067 DNA-binding interface [nucleotide binding]; DNA binding site 932677009068 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 932677009069 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 932677009070 Phage Tail Collar Domain; Region: Collar; pfam07484 932677009071 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 932677009072 baseplate assembly protein; Provisional; Region: J; PHA02568 932677009073 baseplate wedge subunit; Provisional; Region: W; PHA02516 932677009074 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 932677009075 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 932677009076 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 932677009077 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 932677009078 catalytic residues [active] 932677009079 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 932677009080 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 932677009081 DksA-like zinc finger domain containing protein; Region: PHA00080 932677009082 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 932677009083 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 932677009084 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 932677009085 intersubunit interface [polypeptide binding]; other site 932677009086 active site 932677009087 zinc binding site [ion binding]; other site 932677009088 Na+ binding site [ion binding]; other site 932677009089 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 932677009090 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 932677009091 active site 932677009092 P-loop; other site 932677009093 phosphorylation site [posttranslational modification] 932677009094 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 932677009095 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932677009096 active site 932677009097 phosphorylation site [posttranslational modification] 932677009098 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932677009099 HTH domain; Region: HTH_11; pfam08279 932677009100 PRD domain; Region: PRD; pfam00874 932677009101 PRD domain; Region: PRD; pfam00874 932677009102 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932677009103 active site 932677009104 P-loop; other site 932677009105 phosphorylation site [posttranslational modification] 932677009106 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 932677009107 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 932677009108 Sulfate transporter family; Region: Sulfate_transp; pfam00916 932677009109 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 932677009110 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 932677009111 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677009112 dimer interface [polypeptide binding]; other site 932677009113 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 932677009114 putative CheW interface [polypeptide binding]; other site 932677009115 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932677009116 dimerization interface [polypeptide binding]; other site 932677009117 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 932677009118 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677009119 dimer interface [polypeptide binding]; other site 932677009120 putative CheW interface [polypeptide binding]; other site 932677009121 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 932677009122 GAF domain; Region: GAF; pfam01590 932677009123 PAS domain S-box; Region: sensory_box; TIGR00229 932677009124 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932677009125 putative active site [active] 932677009126 heme pocket [chemical binding]; other site 932677009127 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932677009128 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932677009129 metal binding site [ion binding]; metal-binding site 932677009130 active site 932677009131 I-site; other site 932677009132 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932677009133 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 932677009134 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 932677009135 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677009136 dimer interface [polypeptide binding]; other site 932677009137 putative CheW interface [polypeptide binding]; other site 932677009138 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 932677009139 GAF domain; Region: GAF; pfam01590 932677009140 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932677009141 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932677009142 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932677009143 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932677009144 metal binding site [ion binding]; metal-binding site 932677009145 active site 932677009146 I-site; other site 932677009147 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 932677009148 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 932677009149 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 932677009150 MASE1; Region: MASE1; cl17823 932677009151 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932677009152 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932677009153 metal binding site [ion binding]; metal-binding site 932677009154 active site 932677009155 I-site; other site 932677009156 high affinity sulphate transporter 1; Region: sulP; TIGR00815 932677009157 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 932677009158 Sulfate transporter family; Region: Sulfate_transp; pfam00916 932677009159 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 932677009160 active site clefts [active] 932677009161 zinc binding site [ion binding]; other site 932677009162 dimer interface [polypeptide binding]; other site 932677009163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677009164 active site 932677009165 motif I; other site 932677009166 motif II; other site 932677009167 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 932677009168 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 932677009169 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 932677009170 active site 932677009171 FMN binding site [chemical binding]; other site 932677009172 2,4-decadienoyl-CoA binding site; other site 932677009173 catalytic residue [active] 932677009174 4Fe-4S cluster binding site [ion binding]; other site 932677009175 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 932677009176 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932677009177 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 932677009178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677009179 S-adenosylmethionine binding site [chemical binding]; other site 932677009180 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 932677009181 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 932677009182 dimer interface [polypeptide binding]; other site 932677009183 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 932677009184 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 932677009185 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932677009186 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 932677009187 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 932677009188 galactarate dehydratase; Region: galactar-dH20; TIGR03248 932677009189 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 932677009190 altronate oxidoreductase; Provisional; Region: PRK03643 932677009191 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 932677009192 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 932677009193 Glucuronate isomerase; Region: UxaC; pfam02614 932677009194 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 932677009195 D-galactonate transporter; Region: 2A0114; TIGR00893 932677009196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677009197 putative substrate translocation pore; other site 932677009198 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 932677009199 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932677009200 DNA-binding site [nucleotide binding]; DNA binding site 932677009201 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 932677009202 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 932677009203 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 932677009204 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 932677009205 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 932677009206 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 932677009207 Predicted membrane protein [Function unknown]; Region: COG5393 932677009208 YqjK-like protein; Region: YqjK; pfam13997 932677009209 Predicted membrane protein [Function unknown]; Region: COG2259 932677009210 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 932677009211 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 932677009212 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 932677009213 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 932677009214 active site 932677009215 substrate binding site [chemical binding]; other site 932677009216 cosubstrate binding site; other site 932677009217 catalytic site [active] 932677009218 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 932677009219 active site 932677009220 hexamer interface [polypeptide binding]; other site 932677009221 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 932677009222 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 932677009223 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 932677009224 putative dimer interface [polypeptide binding]; other site 932677009225 N-terminal domain interface [polypeptide binding]; other site 932677009226 putative substrate binding pocket (H-site) [chemical binding]; other site 932677009227 threonine/serine transporter TdcC; Provisional; Region: PRK13629 932677009228 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 932677009229 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 932677009230 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 932677009231 tetramer interface [polypeptide binding]; other site 932677009232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677009233 catalytic residue [active] 932677009234 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 932677009235 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 932677009236 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 932677009237 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 932677009238 putative SAM binding site [chemical binding]; other site 932677009239 putative homodimer interface [polypeptide binding]; other site 932677009240 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 932677009241 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 932677009242 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 932677009243 putative ligand binding site [chemical binding]; other site 932677009244 hypothetical protein; Reviewed; Region: PRK12497 932677009245 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 932677009246 active site 932677009247 dimer interface [polypeptide binding]; other site 932677009248 outer membrane lipoprotein; Provisional; Region: PRK11023 932677009249 BON domain; Region: BON; pfam04972 932677009250 BON domain; Region: BON; pfam04972 932677009251 Pirin-related protein [General function prediction only]; Region: COG1741 932677009252 Pirin; Region: Pirin; pfam02678 932677009253 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677009254 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 932677009255 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 932677009256 dimerization interface [polypeptide binding]; other site 932677009257 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 932677009258 Mga helix-turn-helix domain; Region: Mga; pfam05043 932677009259 PRD domain; Region: PRD; pfam00874 932677009260 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 932677009261 active site 932677009262 P-loop; other site 932677009263 phosphorylation site [posttranslational modification] 932677009264 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932677009265 active site 932677009266 phosphorylation site [posttranslational modification] 932677009267 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 932677009268 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 932677009269 dihydroorotase; Provisional; Region: PRK09237 932677009270 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 932677009271 active site 932677009272 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 932677009273 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 932677009274 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 932677009275 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 932677009276 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 932677009277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677009278 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 932677009279 alpha-glucosidase; Provisional; Region: PRK10426 932677009280 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 932677009281 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 932677009282 putative active site [active] 932677009283 putative catalytic site [active] 932677009284 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 932677009285 active site 932677009286 catalytic residues [active] 932677009287 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 932677009288 dimerization interface [polypeptide binding]; other site 932677009289 putative active cleft [active] 932677009290 Class I aldolases; Region: Aldolase_Class_I; cl17187 932677009291 catalytic residue [active] 932677009292 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 932677009293 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 932677009294 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 932677009295 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 932677009296 substrate binding site [chemical binding]; other site 932677009297 ATP binding site [chemical binding]; other site 932677009298 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 932677009299 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932677009300 putative DNA binding site [nucleotide binding]; other site 932677009301 putative Zn2+ binding site [ion binding]; other site 932677009302 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 932677009303 Cytochrome b562; Region: Cytochrom_B562; cl01546 932677009304 peptidase PmbA; Provisional; Region: PRK11040 932677009305 hypothetical protein; Provisional; Region: PRK05255 932677009306 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 932677009307 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 932677009308 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 932677009309 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 932677009310 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 932677009311 AMP binding site [chemical binding]; other site 932677009312 metal binding site [ion binding]; metal-binding site 932677009313 active site 932677009314 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 932677009315 dimer interface [polypeptide binding]; other site 932677009316 ligand binding site [chemical binding]; other site 932677009317 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932677009318 dimerization interface [polypeptide binding]; other site 932677009319 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 932677009320 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677009321 dimer interface [polypeptide binding]; other site 932677009322 putative CheW interface [polypeptide binding]; other site 932677009323 Predicted membrane protein [Function unknown]; Region: COG2707 932677009324 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 932677009325 dimer interface [polypeptide binding]; other site 932677009326 substrate binding site [chemical binding]; other site 932677009327 metal binding sites [ion binding]; metal-binding site 932677009328 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 932677009329 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 932677009330 putative active site pocket [active] 932677009331 dimerization interface [polypeptide binding]; other site 932677009332 putative catalytic residue [active] 932677009333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 932677009334 Family of unknown function (DUF490); Region: DUF490; pfam04357 932677009335 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 932677009336 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 932677009337 Surface antigen; Region: Bac_surface_Ag; pfam01103 932677009338 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 932677009339 Domain of unknown function DUF21; Region: DUF21; pfam01595 932677009340 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 932677009341 Transporter associated domain; Region: CorC_HlyC; smart01091 932677009342 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 932677009343 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 932677009344 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 932677009345 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 932677009346 active site 932677009347 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 932677009348 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 932677009349 active site 932677009350 metal binding site [ion binding]; metal-binding site 932677009351 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 932677009352 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 932677009353 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 932677009354 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 932677009355 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 932677009356 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 932677009357 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 932677009358 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 932677009359 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 932677009360 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 932677009361 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 932677009362 dimer interface [polypeptide binding]; other site 932677009363 ssDNA binding site [nucleotide binding]; other site 932677009364 tetramer (dimer of dimers) interface [polypeptide binding]; other site 932677009365 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 932677009366 esterase; Provisional; Region: PRK10566 932677009367 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 932677009368 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932677009369 dimerization interface [polypeptide binding]; other site 932677009370 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 932677009371 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677009372 dimer interface [polypeptide binding]; other site 932677009373 putative CheW interface [polypeptide binding]; other site 932677009374 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 932677009375 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 932677009376 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 932677009377 active site 932677009378 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 932677009379 exoribonuclease R; Provisional; Region: PRK11642 932677009380 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 932677009381 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 932677009382 RNB domain; Region: RNB; pfam00773 932677009383 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 932677009384 RNA binding site [nucleotide binding]; other site 932677009385 transcriptional repressor NsrR; Provisional; Region: PRK11014 932677009386 Rrf2 family protein; Region: rrf2_super; TIGR00738 932677009387 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 932677009388 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 932677009389 GDP-binding site [chemical binding]; other site 932677009390 ACT binding site; other site 932677009391 IMP binding site; other site 932677009392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 932677009393 FtsH protease regulator HflC; Provisional; Region: PRK11029 932677009394 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 932677009395 FtsH protease regulator HflK; Provisional; Region: PRK10930 932677009396 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 932677009397 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 932677009398 GTPase HflX; Provisional; Region: PRK11058 932677009399 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 932677009400 HflX GTPase family; Region: HflX; cd01878 932677009401 G1 box; other site 932677009402 GTP/Mg2+ binding site [chemical binding]; other site 932677009403 Switch I region; other site 932677009404 G2 box; other site 932677009405 G3 box; other site 932677009406 Switch II region; other site 932677009407 G4 box; other site 932677009408 G5 box; other site 932677009409 bacterial Hfq-like; Region: Hfq; cd01716 932677009410 hexamer interface [polypeptide binding]; other site 932677009411 Sm1 motif; other site 932677009412 RNA binding site [nucleotide binding]; other site 932677009413 Sm2 motif; other site 932677009414 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 932677009415 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 932677009416 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 932677009417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677009418 ATP binding site [chemical binding]; other site 932677009419 Mg2+ binding site [ion binding]; other site 932677009420 G-X-G motif; other site 932677009421 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 932677009422 ATP binding site [chemical binding]; other site 932677009423 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 932677009424 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 932677009425 AMIN domain; Region: AMIN; pfam11741 932677009426 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 932677009427 active site 932677009428 metal binding site [ion binding]; metal-binding site 932677009429 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932677009430 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 932677009431 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 932677009432 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 932677009433 putative carbohydrate kinase; Provisional; Region: PRK10565 932677009434 Uncharacterized conserved protein [Function unknown]; Region: COG0062 932677009435 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 932677009436 putative substrate binding site [chemical binding]; other site 932677009437 putative ATP binding site [chemical binding]; other site 932677009438 epoxyqueuosine reductase; Region: TIGR00276 932677009439 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 932677009440 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 932677009441 catalytic site [active] 932677009442 putative active site [active] 932677009443 putative substrate binding site [chemical binding]; other site 932677009444 dimer interface [polypeptide binding]; other site 932677009445 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 932677009446 RNA binding site [nucleotide binding]; other site 932677009447 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 932677009448 GTP/Mg2+ binding site [chemical binding]; other site 932677009449 G4 box; other site 932677009450 G5 box; other site 932677009451 G1 box; other site 932677009452 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 932677009453 putative mechanosensitive channel protein; Provisional; Region: PRK10929 932677009454 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 932677009455 Mechanosensitive ion channel; Region: MS_channel; pfam00924 932677009456 malate dehydrogenase; Provisional; Region: PRK05086 932677009457 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 932677009458 NAD binding site [chemical binding]; other site 932677009459 dimerization interface [polypeptide binding]; other site 932677009460 Substrate binding site [chemical binding]; other site 932677009461 arginine repressor; Provisional; Region: PRK05066 932677009462 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 932677009463 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 932677009464 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 932677009465 putative transposase; Provisional; Region: PRK09857 932677009466 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 932677009467 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 932677009468 succinic semialdehyde dehydrogenase; Region: PLN02278 932677009469 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 932677009470 tetramerization interface [polypeptide binding]; other site 932677009471 NAD(P) binding site [chemical binding]; other site 932677009472 catalytic residues [active] 932677009473 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 932677009474 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 932677009475 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 932677009476 HlyD family secretion protein; Region: HlyD_3; pfam13437 932677009477 efflux system membrane protein; Provisional; Region: PRK11594 932677009478 transcriptional regulator; Provisional; Region: PRK10632 932677009479 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677009480 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 932677009481 putative effector binding pocket; other site 932677009482 dimerization interface [polypeptide binding]; other site 932677009483 protease TldD; Provisional; Region: tldD; PRK10735 932677009484 hypothetical protein; Provisional; Region: PRK10899 932677009485 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 932677009486 ribonuclease G; Provisional; Region: PRK11712 932677009487 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 932677009488 homodimer interface [polypeptide binding]; other site 932677009489 oligonucleotide binding site [chemical binding]; other site 932677009490 Maf-like protein; Region: Maf; pfam02545 932677009491 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 932677009492 active site 932677009493 dimer interface [polypeptide binding]; other site 932677009494 rod shape-determining protein MreD; Provisional; Region: PRK11060 932677009495 rod shape-determining protein MreC; Region: mreC; TIGR00219 932677009496 rod shape-determining protein MreC; Region: MreC; pfam04085 932677009497 rod shape-determining protein MreB; Provisional; Region: PRK13927 932677009498 MreB and similar proteins; Region: MreB_like; cd10225 932677009499 nucleotide binding site [chemical binding]; other site 932677009500 Mg binding site [ion binding]; other site 932677009501 putative protofilament interaction site [polypeptide binding]; other site 932677009502 RodZ interaction site [polypeptide binding]; other site 932677009503 regulatory protein CsrD; Provisional; Region: PRK11059 932677009504 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932677009505 active site 932677009506 I-site; other site 932677009507 metal binding site [ion binding]; metal-binding site 932677009508 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932677009509 TMAO/DMSO reductase; Reviewed; Region: PRK05363 932677009510 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 932677009511 Moco binding site; other site 932677009512 metal coordination site [ion binding]; other site 932677009513 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 932677009514 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 932677009515 Dehydroquinase class II; Region: DHquinase_II; pfam01220 932677009516 active site 932677009517 trimer interface [polypeptide binding]; other site 932677009518 dimer interface [polypeptide binding]; other site 932677009519 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 932677009520 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 932677009521 carboxyltransferase (CT) interaction site; other site 932677009522 biotinylation site [posttranslational modification]; other site 932677009523 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 932677009524 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 932677009525 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 932677009526 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 932677009527 hypothetical protein; Provisional; Region: PRK10633 932677009528 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 932677009529 Na binding site [ion binding]; other site 932677009530 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 932677009531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 932677009532 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 932677009533 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 932677009534 FMN binding site [chemical binding]; other site 932677009535 active site 932677009536 catalytic residues [active] 932677009537 substrate binding site [chemical binding]; other site 932677009538 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 932677009539 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 932677009540 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677009541 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 932677009542 substrate binding pocket [chemical binding]; other site 932677009543 membrane-bound complex binding site; other site 932677009544 hinge residues; other site 932677009545 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 932677009546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677009547 conserved gate region; other site 932677009548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677009549 ABC-ATPase subunit interface; other site 932677009550 putative PBP binding loops; other site 932677009551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677009552 dimer interface [polypeptide binding]; other site 932677009553 conserved gate region; other site 932677009554 putative PBP binding loops; other site 932677009555 ABC-ATPase subunit interface; other site 932677009556 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 932677009557 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 932677009558 Walker A/P-loop; other site 932677009559 ATP binding site [chemical binding]; other site 932677009560 Q-loop/lid; other site 932677009561 ABC transporter signature motif; other site 932677009562 Walker B; other site 932677009563 D-loop; other site 932677009564 H-loop/switch region; other site 932677009565 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 932677009566 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 932677009567 trimer interface [polypeptide binding]; other site 932677009568 putative metal binding site [ion binding]; other site 932677009569 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 932677009570 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 932677009571 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 932677009572 shikimate binding site; other site 932677009573 NAD(P) binding site [chemical binding]; other site 932677009574 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 932677009575 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 932677009576 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 932677009577 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 932677009578 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 932677009579 hypothetical protein; Validated; Region: PRK03430 932677009580 hypothetical protein; Provisional; Region: PRK10736 932677009581 DNA protecting protein DprA; Region: dprA; TIGR00732 932677009582 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 932677009583 active site 932677009584 catalytic residues [active] 932677009585 metal binding site [ion binding]; metal-binding site 932677009586 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 932677009587 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 932677009588 putative active site [active] 932677009589 putative cosubstrate binding site; other site 932677009590 substrate binding site [chemical binding]; other site 932677009591 catalytic site [active] 932677009592 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 932677009593 substrate binding site [chemical binding]; other site 932677009594 16S rRNA methyltransferase B; Provisional; Region: PRK10901 932677009595 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 932677009596 putative RNA binding site [nucleotide binding]; other site 932677009597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677009598 S-adenosylmethionine binding site [chemical binding]; other site 932677009599 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 932677009600 TrkA-N domain; Region: TrkA_N; pfam02254 932677009601 TrkA-C domain; Region: TrkA_C; pfam02080 932677009602 TrkA-N domain; Region: TrkA_N; pfam02254 932677009603 TrkA-C domain; Region: TrkA_C; pfam02080 932677009604 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 932677009605 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 932677009606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 932677009607 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 932677009608 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 932677009609 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 932677009610 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 932677009611 alphaNTD homodimer interface [polypeptide binding]; other site 932677009612 alphaNTD - beta interaction site [polypeptide binding]; other site 932677009613 alphaNTD - beta' interaction site [polypeptide binding]; other site 932677009614 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 932677009615 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 932677009616 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 932677009617 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932677009618 RNA binding surface [nucleotide binding]; other site 932677009619 30S ribosomal protein S11; Validated; Region: PRK05309 932677009620 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 932677009621 30S ribosomal protein S13; Region: bact_S13; TIGR03631 932677009622 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 932677009623 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 932677009624 SecY translocase; Region: SecY; pfam00344 932677009625 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 932677009626 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 932677009627 23S rRNA binding site [nucleotide binding]; other site 932677009628 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 932677009629 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 932677009630 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 932677009631 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 932677009632 23S rRNA interface [nucleotide binding]; other site 932677009633 5S rRNA interface [nucleotide binding]; other site 932677009634 L27 interface [polypeptide binding]; other site 932677009635 L5 interface [polypeptide binding]; other site 932677009636 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 932677009637 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 932677009638 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 932677009639 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 932677009640 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 932677009641 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 932677009642 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 932677009643 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 932677009644 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 932677009645 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 932677009646 RNA binding site [nucleotide binding]; other site 932677009647 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 932677009648 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 932677009649 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 932677009650 23S rRNA interface [nucleotide binding]; other site 932677009651 putative translocon interaction site; other site 932677009652 signal recognition particle (SRP54) interaction site; other site 932677009653 L23 interface [polypeptide binding]; other site 932677009654 trigger factor interaction site; other site 932677009655 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 932677009656 23S rRNA interface [nucleotide binding]; other site 932677009657 5S rRNA interface [nucleotide binding]; other site 932677009658 putative antibiotic binding site [chemical binding]; other site 932677009659 L25 interface [polypeptide binding]; other site 932677009660 L27 interface [polypeptide binding]; other site 932677009661 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 932677009662 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 932677009663 G-X-X-G motif; other site 932677009664 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 932677009665 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 932677009666 protein-rRNA interface [nucleotide binding]; other site 932677009667 putative translocon binding site; other site 932677009668 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 932677009669 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 932677009670 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 932677009671 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 932677009672 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 932677009673 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 932677009674 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 932677009675 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 932677009676 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 932677009677 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 932677009678 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 932677009679 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 932677009680 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 932677009681 heme binding site [chemical binding]; other site 932677009682 ferroxidase pore; other site 932677009683 ferroxidase diiron center [ion binding]; other site 932677009684 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 932677009685 elongation factor Tu; Reviewed; Region: PRK00049 932677009686 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 932677009687 G1 box; other site 932677009688 GEF interaction site [polypeptide binding]; other site 932677009689 GTP/Mg2+ binding site [chemical binding]; other site 932677009690 Switch I region; other site 932677009691 G2 box; other site 932677009692 G3 box; other site 932677009693 Switch II region; other site 932677009694 G4 box; other site 932677009695 G5 box; other site 932677009696 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 932677009697 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 932677009698 Antibiotic Binding Site [chemical binding]; other site 932677009699 elongation factor G; Reviewed; Region: PRK00007 932677009700 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 932677009701 G1 box; other site 932677009702 putative GEF interaction site [polypeptide binding]; other site 932677009703 GTP/Mg2+ binding site [chemical binding]; other site 932677009704 Switch I region; other site 932677009705 G2 box; other site 932677009706 G3 box; other site 932677009707 Switch II region; other site 932677009708 G4 box; other site 932677009709 G5 box; other site 932677009710 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 932677009711 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 932677009712 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 932677009713 30S ribosomal protein S7; Validated; Region: PRK05302 932677009714 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 932677009715 S17 interaction site [polypeptide binding]; other site 932677009716 S8 interaction site; other site 932677009717 16S rRNA interaction site [nucleotide binding]; other site 932677009718 streptomycin interaction site [chemical binding]; other site 932677009719 23S rRNA interaction site [nucleotide binding]; other site 932677009720 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 932677009721 DsrH like protein; Region: DsrH; cl17347 932677009722 sulfur relay protein TusC; Validated; Region: PRK00211 932677009723 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 932677009724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 932677009725 YheO-like PAS domain; Region: PAS_6; pfam08348 932677009726 HTH domain; Region: HTH_22; pfam13309 932677009727 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 932677009728 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 932677009729 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 932677009730 phi X174 lysis protein; Provisional; Region: PRK02793 932677009731 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 932677009732 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 932677009733 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 932677009734 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 932677009735 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 932677009736 TrkA-N domain; Region: TrkA_N; pfam02254 932677009737 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 932677009738 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 932677009739 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932677009740 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932677009741 ABC transporter; Region: ABC_tran_2; pfam12848 932677009742 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932677009743 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 932677009744 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 932677009745 active site 932677009746 iron coordination sites [ion binding]; other site 932677009747 substrate binding pocket [chemical binding]; other site 932677009748 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 932677009749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677009750 dimer interface [polypeptide binding]; other site 932677009751 conserved gate region; other site 932677009752 putative PBP binding loops; other site 932677009753 ABC-ATPase subunit interface; other site 932677009754 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 932677009755 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 932677009756 Walker A/P-loop; other site 932677009757 ATP binding site [chemical binding]; other site 932677009758 Q-loop/lid; other site 932677009759 ABC transporter signature motif; other site 932677009760 Walker B; other site 932677009761 D-loop; other site 932677009762 H-loop/switch region; other site 932677009763 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 932677009764 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677009765 substrate binding pocket [chemical binding]; other site 932677009766 membrane-bound complex binding site; other site 932677009767 hinge residues; other site 932677009768 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932677009769 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932677009770 DNA binding site [nucleotide binding] 932677009771 domain linker motif; other site 932677009772 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 932677009773 dimerization interface [polypeptide binding]; other site 932677009774 ligand binding site [chemical binding]; other site 932677009775 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 932677009776 putative hydrolase; Provisional; Region: PRK10985 932677009777 hypothetical protein; Provisional; Region: PRK04966 932677009778 phosphoribulokinase; Provisional; Region: PRK15453 932677009779 hypothetical protein; Provisional; Region: PRK10738 932677009780 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 932677009781 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 932677009782 ligand binding site [chemical binding]; other site 932677009783 flexible hinge region; other site 932677009784 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 932677009785 putative switch regulator; other site 932677009786 non-specific DNA interactions [nucleotide binding]; other site 932677009787 DNA binding site [nucleotide binding] 932677009788 sequence specific DNA binding site [nucleotide binding]; other site 932677009789 putative cAMP binding site [chemical binding]; other site 932677009790 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 932677009791 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 932677009792 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 932677009793 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 932677009794 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 932677009795 inhibitor-cofactor binding pocket; inhibition site 932677009796 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677009797 catalytic residue [active] 932677009798 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 932677009799 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 932677009800 glutamine binding [chemical binding]; other site 932677009801 catalytic triad [active] 932677009802 Fic/DOC family; Region: Fic; cl00960 932677009803 hypothetical protein; Provisional; Region: PRK10204 932677009804 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 932677009805 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 932677009806 substrate binding site [chemical binding]; other site 932677009807 putative transporter; Provisional; Region: PRK03699 932677009808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677009809 putative substrate translocation pore; other site 932677009810 cytosine deaminase; Provisional; Region: PRK09230 932677009811 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 932677009812 active site 932677009813 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 932677009814 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 932677009815 active site 932677009816 HIGH motif; other site 932677009817 dimer interface [polypeptide binding]; other site 932677009818 KMSKS motif; other site 932677009819 phosphoglycolate phosphatase; Provisional; Region: PRK13222 932677009820 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 932677009821 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677009822 motif II; other site 932677009823 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 932677009824 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 932677009825 substrate binding site [chemical binding]; other site 932677009826 hexamer interface [polypeptide binding]; other site 932677009827 metal binding site [ion binding]; metal-binding site 932677009828 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 932677009829 hypothetical protein; Reviewed; Region: PRK11901 932677009830 cell division protein DamX; Validated; Region: PRK10905 932677009831 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 932677009832 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 932677009833 active site 932677009834 dimer interface [polypeptide binding]; other site 932677009835 metal binding site [ion binding]; metal-binding site 932677009836 shikimate kinase; Reviewed; Region: aroK; PRK00131 932677009837 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 932677009838 ADP binding site [chemical binding]; other site 932677009839 magnesium binding site [ion binding]; other site 932677009840 putative shikimate binding site; other site 932677009841 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 932677009842 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 932677009843 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 932677009844 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 932677009845 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 932677009846 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 932677009847 Transglycosylase; Region: Transgly; pfam00912 932677009848 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 932677009849 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 932677009850 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 932677009851 ADP-ribose binding site [chemical binding]; other site 932677009852 dimer interface [polypeptide binding]; other site 932677009853 active site 932677009854 nudix motif; other site 932677009855 metal binding site [ion binding]; metal-binding site 932677009856 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 932677009857 GMP/IMP nucleotidase; Provisional; Region: PRK14988 932677009858 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 932677009859 motif II; other site 932677009860 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932677009861 RNA binding surface [nucleotide binding]; other site 932677009862 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 932677009863 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 932677009864 dimerization interface [polypeptide binding]; other site 932677009865 domain crossover interface; other site 932677009866 redox-dependent activation switch; other site 932677009867 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 932677009868 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 932677009869 active site 932677009870 substrate-binding site [chemical binding]; other site 932677009871 metal-binding site [ion binding] 932677009872 ATP binding site [chemical binding]; other site 932677009873 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 932677009874 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932677009875 dimerization interface [polypeptide binding]; other site 932677009876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932677009877 dimer interface [polypeptide binding]; other site 932677009878 phosphorylation site [posttranslational modification] 932677009879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677009880 ATP binding site [chemical binding]; other site 932677009881 Mg2+ binding site [ion binding]; other site 932677009882 G-X-G motif; other site 932677009883 osmolarity response regulator; Provisional; Region: ompR; PRK09468 932677009884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677009885 active site 932677009886 phosphorylation site [posttranslational modification] 932677009887 intermolecular recognition site; other site 932677009888 dimerization interface [polypeptide binding]; other site 932677009889 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932677009890 DNA binding site [nucleotide binding] 932677009891 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 932677009892 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 932677009893 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 932677009894 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 932677009895 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 932677009896 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 932677009897 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 932677009898 RNA binding site [nucleotide binding]; other site 932677009899 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 932677009900 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 932677009901 active site 932677009902 homodimer interface [polypeptide binding]; other site 932677009903 catalytic site [active] 932677009904 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 932677009905 carboxylesterase BioH; Provisional; Region: PRK10349 932677009906 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 932677009907 DNA utilization protein GntX; Provisional; Region: PRK11595 932677009908 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932677009909 active site 932677009910 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 932677009911 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 932677009912 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 932677009913 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 932677009914 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 932677009915 maltodextrin phosphorylase; Provisional; Region: PRK14985 932677009916 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 932677009917 homodimer interface [polypeptide binding]; other site 932677009918 active site pocket [active] 932677009919 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 932677009920 intramembrane serine protease GlpG; Provisional; Region: PRK10907 932677009921 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 932677009922 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 932677009923 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 932677009924 active site residue [active] 932677009925 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 932677009926 glycogen phosphorylase; Provisional; Region: PRK14986 932677009927 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 932677009928 homodimer interface [polypeptide binding]; other site 932677009929 active site pocket [active] 932677009930 glycogen synthase; Provisional; Region: glgA; PRK00654 932677009931 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 932677009932 ADP-binding pocket [chemical binding]; other site 932677009933 homodimer interface [polypeptide binding]; other site 932677009934 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 932677009935 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 932677009936 ligand binding site; other site 932677009937 oligomer interface; other site 932677009938 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 932677009939 dimer interface [polypeptide binding]; other site 932677009940 N-terminal domain interface [polypeptide binding]; other site 932677009941 sulfate 1 binding site; other site 932677009942 glycogen debranching enzyme; Provisional; Region: PRK03705 932677009943 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 932677009944 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 932677009945 active site 932677009946 catalytic site [active] 932677009947 glycogen branching enzyme; Provisional; Region: PRK05402 932677009948 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 932677009949 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 932677009950 active site 932677009951 catalytic site [active] 932677009952 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 932677009953 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 932677009954 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 932677009955 putative antibiotic transporter; Provisional; Region: PRK10739 932677009956 low affinity gluconate transporter; Provisional; Region: PRK10472 932677009957 gluconate transporter; Region: gntP; TIGR00791 932677009958 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 932677009959 ATP-binding site [chemical binding]; other site 932677009960 Gluconate-6-phosphate binding site [chemical binding]; other site 932677009961 Shikimate kinase; Region: SKI; pfam01202 932677009962 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 932677009963 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932677009964 DNA binding site [nucleotide binding] 932677009965 domain linker motif; other site 932677009966 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 932677009967 putative ligand binding site [chemical binding]; other site 932677009968 putative dimerization interface [polypeptide binding]; other site 932677009969 Pirin-related protein [General function prediction only]; Region: COG1741 932677009970 Pirin; Region: Pirin; pfam02678 932677009971 putative acetyltransferase YhhY; Provisional; Region: PRK10140 932677009972 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677009973 Coenzyme A binding pocket [chemical binding]; other site 932677009974 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 932677009975 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 932677009976 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 932677009977 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 932677009978 putative active site [active] 932677009979 catalytic site [active] 932677009980 putative metal binding site [ion binding]; other site 932677009981 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 932677009982 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 932677009983 Walker A/P-loop; other site 932677009984 ATP binding site [chemical binding]; other site 932677009985 Q-loop/lid; other site 932677009986 ABC transporter signature motif; other site 932677009987 Walker B; other site 932677009988 D-loop; other site 932677009989 H-loop/switch region; other site 932677009990 TOBE domain; Region: TOBE_2; pfam08402 932677009991 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 932677009992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677009993 dimer interface [polypeptide binding]; other site 932677009994 conserved gate region; other site 932677009995 putative PBP binding loops; other site 932677009996 ABC-ATPase subunit interface; other site 932677009997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677009998 dimer interface [polypeptide binding]; other site 932677009999 conserved gate region; other site 932677010000 putative PBP binding loops; other site 932677010001 ABC-ATPase subunit interface; other site 932677010002 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 932677010003 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 932677010004 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 932677010005 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 932677010006 Walker A/P-loop; other site 932677010007 ATP binding site [chemical binding]; other site 932677010008 Q-loop/lid; other site 932677010009 ABC transporter signature motif; other site 932677010010 Walker B; other site 932677010011 D-loop; other site 932677010012 H-loop/switch region; other site 932677010013 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 932677010014 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 932677010015 Walker A/P-loop; other site 932677010016 ATP binding site [chemical binding]; other site 932677010017 Q-loop/lid; other site 932677010018 ABC transporter signature motif; other site 932677010019 Walker B; other site 932677010020 D-loop; other site 932677010021 H-loop/switch region; other site 932677010022 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 932677010023 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 932677010024 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 932677010025 TM-ABC transporter signature motif; other site 932677010026 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932677010027 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 932677010028 TM-ABC transporter signature motif; other site 932677010029 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 932677010030 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 932677010031 dimerization interface [polypeptide binding]; other site 932677010032 ligand binding site [chemical binding]; other site 932677010033 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 932677010034 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 932677010035 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 932677010036 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 932677010037 DNA binding residues [nucleotide binding] 932677010038 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 932677010039 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 932677010040 cell division protein FtsE; Provisional; Region: PRK10908 932677010041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677010042 Walker A/P-loop; other site 932677010043 ATP binding site [chemical binding]; other site 932677010044 Q-loop/lid; other site 932677010045 ABC transporter signature motif; other site 932677010046 Walker B; other site 932677010047 D-loop; other site 932677010048 H-loop/switch region; other site 932677010049 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 932677010050 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 932677010051 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 932677010052 P loop; other site 932677010053 GTP binding site [chemical binding]; other site 932677010054 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 932677010055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677010056 S-adenosylmethionine binding site [chemical binding]; other site 932677010057 hypothetical protein; Provisional; Region: PRK10910 932677010058 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 932677010059 Predicted membrane protein [Function unknown]; Region: COG3714 932677010060 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 932677010061 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 932677010062 metal-binding site [ion binding] 932677010063 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 932677010064 Soluble P-type ATPase [General function prediction only]; Region: COG4087 932677010065 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 932677010066 CPxP motif; other site 932677010067 hypothetical protein; Provisional; Region: PRK11212 932677010068 hypothetical protein; Provisional; Region: PRK11615 932677010069 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 932677010070 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 932677010071 substrate binding site [chemical binding]; other site 932677010072 ATP binding site [chemical binding]; other site 932677010073 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 932677010074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 932677010075 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 932677010076 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 932677010077 PYR/PP interface [polypeptide binding]; other site 932677010078 dimer interface [polypeptide binding]; other site 932677010079 TPP binding site [chemical binding]; other site 932677010080 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 932677010081 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 932677010082 TPP-binding site; other site 932677010083 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 932677010084 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932677010085 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 932677010086 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 932677010087 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 932677010088 Metal-binding active site; metal-binding site 932677010089 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 932677010090 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 932677010091 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932677010092 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932677010093 putative active site [active] 932677010094 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 932677010095 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 932677010096 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 932677010097 tetrameric interface [polypeptide binding]; other site 932677010098 NAD binding site [chemical binding]; other site 932677010099 catalytic residues [active] 932677010100 xanthine permease; Region: pbuX; TIGR03173 932677010101 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 932677010102 Domain of unknown function DUF20; Region: UPF0118; pfam01594 932677010103 Transcriptional regulators [Transcription]; Region: FadR; COG2186 932677010104 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932677010105 DNA-binding site [nucleotide binding]; DNA binding site 932677010106 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 932677010107 mannonate dehydratase; Region: uxuA; TIGR00695 932677010108 mannonate dehydratase; Provisional; Region: PRK03906 932677010109 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 932677010110 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932677010111 proline/glycine betaine transporter; Provisional; Region: PRK10642 932677010112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677010113 putative substrate translocation pore; other site 932677010114 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 932677010115 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 932677010116 dimer interface [polypeptide binding]; other site 932677010117 active site 932677010118 Schiff base residues; other site 932677010119 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 932677010120 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677010121 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677010122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 932677010123 short chain dehydrogenase; Provisional; Region: PRK08177 932677010124 C factor cell-cell signaling protein; Provisional; Region: PRK09009 932677010125 NAD(P) binding site [chemical binding]; other site 932677010126 active site 932677010127 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 932677010128 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932677010129 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 932677010130 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 932677010131 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 932677010132 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 932677010133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677010134 dimer interface [polypeptide binding]; other site 932677010135 conserved gate region; other site 932677010136 putative PBP binding loops; other site 932677010137 ABC-ATPase subunit interface; other site 932677010138 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 932677010139 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 932677010140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677010141 dimer interface [polypeptide binding]; other site 932677010142 conserved gate region; other site 932677010143 putative PBP binding loops; other site 932677010144 ABC-ATPase subunit interface; other site 932677010145 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 932677010146 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932677010147 Walker A/P-loop; other site 932677010148 ATP binding site [chemical binding]; other site 932677010149 Q-loop/lid; other site 932677010150 ABC transporter signature motif; other site 932677010151 Walker B; other site 932677010152 D-loop; other site 932677010153 H-loop/switch region; other site 932677010154 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 932677010155 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 932677010156 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932677010157 Walker A/P-loop; other site 932677010158 ATP binding site [chemical binding]; other site 932677010159 Q-loop/lid; other site 932677010160 ABC transporter signature motif; other site 932677010161 Walker B; other site 932677010162 D-loop; other site 932677010163 H-loop/switch region; other site 932677010164 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 932677010165 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 932677010166 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 932677010167 hydroxyglutarate oxidase; Provisional; Region: PRK11728 932677010168 Predicted flavoproteins [General function prediction only]; Region: COG2081 932677010169 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932677010170 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 932677010171 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 932677010172 universal stress protein UspB; Provisional; Region: PRK04960 932677010173 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 932677010174 Ligand Binding Site [chemical binding]; other site 932677010175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677010176 S-adenosylmethionine binding site [chemical binding]; other site 932677010177 oligopeptidase A; Provisional; Region: PRK10911 932677010178 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 932677010179 active site 932677010180 Zn binding site [ion binding]; other site 932677010181 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 932677010182 CAAX protease self-immunity; Region: Abi; pfam02517 932677010183 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 932677010184 glutathione reductase; Validated; Region: PRK06116 932677010185 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932677010186 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932677010187 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 932677010188 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932677010189 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 932677010190 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 932677010191 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 932677010192 active site 932677010193 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 932677010194 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677010195 Walker A/P-loop; other site 932677010196 ATP binding site [chemical binding]; other site 932677010197 Q-loop/lid; other site 932677010198 ABC transporter signature motif; other site 932677010199 Walker B; other site 932677010200 D-loop; other site 932677010201 H-loop/switch region; other site 932677010202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677010203 conserved gate region; other site 932677010204 ABC-ATPase subunit interface; other site 932677010205 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 932677010206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677010207 dimer interface [polypeptide binding]; other site 932677010208 conserved gate region; other site 932677010209 putative PBP binding loops; other site 932677010210 ABC-ATPase subunit interface; other site 932677010211 hypothetical protein; Provisional; Region: PRK11622 932677010212 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 932677010213 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 932677010214 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 932677010215 putative active site [active] 932677010216 catalytic site [active] 932677010217 putative metal binding site [ion binding]; other site 932677010218 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 932677010219 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 932677010220 trimer interface [polypeptide binding]; other site 932677010221 eyelet of channel; other site 932677010222 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 932677010223 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 932677010224 nucleophilic elbow; other site 932677010225 catalytic triad; other site 932677010226 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 932677010227 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 932677010228 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 932677010229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677010230 putative substrate translocation pore; other site 932677010231 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677010232 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677010233 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 932677010234 putative effector binding pocket; other site 932677010235 dimerization interface [polypeptide binding]; other site 932677010236 hypothetical protein; Provisional; Region: PRK05208 932677010237 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 932677010238 GAF domain; Region: GAF_3; pfam13492 932677010239 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932677010240 dimer interface [polypeptide binding]; other site 932677010241 phosphorylation site [posttranslational modification] 932677010242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677010243 ATP binding site [chemical binding]; other site 932677010244 Mg2+ binding site [ion binding]; other site 932677010245 G-X-G motif; other site 932677010246 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 932677010247 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 932677010248 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 932677010249 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 932677010250 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 932677010251 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 932677010252 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932677010253 Zn2+ binding site [ion binding]; other site 932677010254 Mg2+ binding site [ion binding]; other site 932677010255 putative acetyltransferase YhhY; Provisional; Region: PRK10140 932677010256 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677010257 Coenzyme A binding pocket [chemical binding]; other site 932677010258 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 932677010259 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 932677010260 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677010261 Walker A/P-loop; other site 932677010262 ATP binding site [chemical binding]; other site 932677010263 Q-loop/lid; other site 932677010264 ABC transporter signature motif; other site 932677010265 Walker B; other site 932677010266 D-loop; other site 932677010267 H-loop/switch region; other site 932677010268 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 932677010269 Protein of unknown function, DUF482; Region: DUF482; pfam04339 932677010270 putative hydrolase; Provisional; Region: PRK11460 932677010271 Predicted esterase [General function prediction only]; Region: COG0400 932677010272 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 932677010273 active site 932677010274 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 932677010275 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 932677010276 putative NAD(P) binding site [chemical binding]; other site 932677010277 catalytic Zn binding site [ion binding]; other site 932677010278 structural Zn binding site [ion binding]; other site 932677010279 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932677010280 DNA-binding site [nucleotide binding]; DNA binding site 932677010281 Transcriptional regulators [Transcription]; Region: FadR; COG2186 932677010282 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 932677010283 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 932677010284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677010285 D-galactonate transporter; Region: 2A0114; TIGR00893 932677010286 putative substrate translocation pore; other site 932677010287 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 932677010288 TAP-like protein; Region: Abhydrolase_4; pfam08386 932677010289 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 932677010290 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 932677010291 hypothetical protein; Provisional; Region: PRK11469 932677010292 Domain of unknown function DUF; Region: DUF204; pfam02659 932677010293 Domain of unknown function DUF; Region: DUF204; pfam02659 932677010294 malate:quinone oxidoreductase; Validated; Region: PRK05257 932677010295 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 932677010296 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 932677010297 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932677010298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677010299 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 932677010300 homodimer interface [polypeptide binding]; other site 932677010301 catalytic residue [active] 932677010302 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 932677010303 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 932677010304 putative C-terminal domain interface [polypeptide binding]; other site 932677010305 putative GSH binding site (G-site) [chemical binding]; other site 932677010306 putative dimer interface [polypeptide binding]; other site 932677010307 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 932677010308 putative N-terminal domain interface [polypeptide binding]; other site 932677010309 putative dimer interface [polypeptide binding]; other site 932677010310 putative substrate binding pocket (H-site) [chemical binding]; other site 932677010311 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 932677010312 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 932677010313 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 932677010314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932677010315 NAD(P) binding site [chemical binding]; other site 932677010316 active site 932677010317 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677010318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677010319 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 932677010320 putative effector binding pocket; other site 932677010321 putative dimerization interface [polypeptide binding]; other site 932677010322 inner membrane protein YhjD; Region: TIGR00766 932677010323 metabolite-proton symporter; Region: 2A0106; TIGR00883 932677010324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677010325 putative substrate translocation pore; other site 932677010326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677010327 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 932677010328 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 932677010329 putative effector binding pocket; other site 932677010330 dimerization interface [polypeptide binding]; other site 932677010331 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 932677010332 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677010333 substrate binding pocket [chemical binding]; other site 932677010334 membrane-bound complex binding site; other site 932677010335 hinge residues; other site 932677010336 Biofilm formation and stress response factor; Region: BsmA; pfam10014 932677010337 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 932677010338 classical (c) SDRs; Region: SDR_c; cd05233 932677010339 NAD(P) binding site [chemical binding]; other site 932677010340 active site 932677010341 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 932677010342 H+ Antiporter protein; Region: 2A0121; TIGR00900 932677010343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677010344 putative substrate translocation pore; other site 932677010345 ketol-acid reductoisomerase; Validated; Region: PRK05225 932677010346 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 932677010347 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 932677010348 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 932677010349 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677010350 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 932677010351 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 932677010352 putative dimerization interface [polypeptide binding]; other site 932677010353 threonine dehydratase; Reviewed; Region: PRK09224 932677010354 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 932677010355 tetramer interface [polypeptide binding]; other site 932677010356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677010357 catalytic residue [active] 932677010358 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 932677010359 putative Ile/Val binding site [chemical binding]; other site 932677010360 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 932677010361 putative Ile/Val binding site [chemical binding]; other site 932677010362 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 932677010363 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 932677010364 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 932677010365 homodimer interface [polypeptide binding]; other site 932677010366 substrate-cofactor binding pocket; other site 932677010367 catalytic residue [active] 932677010368 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 932677010369 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 932677010370 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 932677010371 PYR/PP interface [polypeptide binding]; other site 932677010372 dimer interface [polypeptide binding]; other site 932677010373 TPP binding site [chemical binding]; other site 932677010374 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 932677010375 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 932677010376 TPP-binding site [chemical binding]; other site 932677010377 dimer interface [polypeptide binding]; other site 932677010378 putative ATP-dependent protease; Provisional; Region: PRK09862 932677010379 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 932677010380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677010381 Walker A motif; other site 932677010382 ATP binding site [chemical binding]; other site 932677010383 Walker B motif; other site 932677010384 arginine finger; other site 932677010385 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 932677010386 hypothetical protein; Provisional; Region: PRK11027 932677010387 LysR substrate binding domain; Region: LysR_substrate; pfam03466 932677010388 dimerization interface [polypeptide binding]; other site 932677010389 glutamate racemase; Provisional; Region: PRK00865 932677010390 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 932677010391 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 932677010392 N-terminal plug; other site 932677010393 ligand-binding site [chemical binding]; other site 932677010394 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 932677010395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677010396 S-adenosylmethionine binding site [chemical binding]; other site 932677010397 hypothetical protein; Provisional; Region: PRK11056 932677010398 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 932677010399 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932677010400 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 932677010401 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 932677010402 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 932677010403 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 932677010404 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677010405 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 932677010406 dimerization interface [polypeptide binding]; other site 932677010407 argininosuccinate lyase; Provisional; Region: PRK04833 932677010408 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 932677010409 active sites [active] 932677010410 tetramer interface [polypeptide binding]; other site 932677010411 argininosuccinate synthase; Provisional; Region: PRK13820 932677010412 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 932677010413 ANP binding site [chemical binding]; other site 932677010414 Substrate Binding Site II [chemical binding]; other site 932677010415 Substrate Binding Site I [chemical binding]; other site 932677010416 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 932677010417 nucleotide binding site [chemical binding]; other site 932677010418 N-acetyl-L-glutamate binding site [chemical binding]; other site 932677010419 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 932677010420 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 932677010421 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 932677010422 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 932677010423 metal binding site [ion binding]; metal-binding site 932677010424 putative dimer interface [polypeptide binding]; other site 932677010425 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 932677010426 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 932677010427 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 932677010428 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932677010429 dimerization interface [polypeptide binding]; other site 932677010430 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 932677010431 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677010432 dimer interface [polypeptide binding]; other site 932677010433 putative CheW interface [polypeptide binding]; other site 932677010434 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 932677010435 FAD binding site [chemical binding]; other site 932677010436 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 932677010437 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 932677010438 putative catalytic residues [active] 932677010439 putative nucleotide binding site [chemical binding]; other site 932677010440 putative aspartate binding site [chemical binding]; other site 932677010441 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 932677010442 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 932677010443 cystathionine gamma-synthase; Provisional; Region: PRK08045 932677010444 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 932677010445 homodimer interface [polypeptide binding]; other site 932677010446 substrate-cofactor binding pocket; other site 932677010447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677010448 catalytic residue [active] 932677010449 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 932677010450 dimerization interface [polypeptide binding]; other site 932677010451 DNA binding site [nucleotide binding] 932677010452 corepressor binding sites; other site 932677010453 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 932677010454 primosome assembly protein PriA; Validated; Region: PRK05580 932677010455 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932677010456 ATP binding site [chemical binding]; other site 932677010457 putative Mg++ binding site [ion binding]; other site 932677010458 helicase superfamily c-terminal domain; Region: HELICc; smart00490 932677010459 ATP-binding site [chemical binding]; other site 932677010460 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932677010461 DNA binding site [nucleotide binding] 932677010462 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 932677010463 domain linker motif; other site 932677010464 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 932677010465 dimerization interface [polypeptide binding]; other site 932677010466 ligand binding site [chemical binding]; other site 932677010467 cell division protein FtsN; Provisional; Region: PRK12757 932677010468 Sporulation related domain; Region: SPOR; cl10051 932677010469 Sporulation related domain; Region: SPOR; cl10051 932677010470 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 932677010471 active site 932677010472 HslU subunit interaction site [polypeptide binding]; other site 932677010473 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 932677010474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677010475 Walker A motif; other site 932677010476 ATP binding site [chemical binding]; other site 932677010477 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 932677010478 Walker B motif; other site 932677010479 arginine finger; other site 932677010480 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 932677010481 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 932677010482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 932677010483 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 932677010484 amphipathic channel; other site 932677010485 Asn-Pro-Ala signature motifs; other site 932677010486 glycerol kinase; Provisional; Region: glpK; PRK00047 932677010487 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 932677010488 N- and C-terminal domain interface [polypeptide binding]; other site 932677010489 active site 932677010490 MgATP binding site [chemical binding]; other site 932677010491 catalytic site [active] 932677010492 metal binding site [ion binding]; metal-binding site 932677010493 glycerol binding site [chemical binding]; other site 932677010494 homotetramer interface [polypeptide binding]; other site 932677010495 homodimer interface [polypeptide binding]; other site 932677010496 FBP binding site [chemical binding]; other site 932677010497 protein IIAGlc interface [polypeptide binding]; other site 932677010498 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 932677010499 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 932677010500 putative active site [active] 932677010501 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 932677010502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677010503 putative substrate translocation pore; other site 932677010504 ferredoxin-NADP reductase; Provisional; Region: PRK10926 932677010505 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 932677010506 FAD binding pocket [chemical binding]; other site 932677010507 FAD binding motif [chemical binding]; other site 932677010508 phosphate binding motif [ion binding]; other site 932677010509 beta-alpha-beta structure motif; other site 932677010510 NAD binding pocket [chemical binding]; other site 932677010511 Predicted membrane protein [Function unknown]; Region: COG3152 932677010512 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 932677010513 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 932677010514 triosephosphate isomerase; Provisional; Region: PRK14567 932677010515 substrate binding site [chemical binding]; other site 932677010516 dimer interface [polypeptide binding]; other site 932677010517 catalytic triad [active] 932677010518 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 932677010519 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 932677010520 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677010521 substrate binding pocket [chemical binding]; other site 932677010522 membrane-bound complex binding site; other site 932677010523 hinge residues; other site 932677010524 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 932677010525 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 932677010526 active site 932677010527 ADP/pyrophosphate binding site [chemical binding]; other site 932677010528 dimerization interface [polypeptide binding]; other site 932677010529 allosteric effector site; other site 932677010530 fructose-1,6-bisphosphate binding site; other site 932677010531 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 932677010532 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 932677010533 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 932677010534 dimer interface [polypeptide binding]; other site 932677010535 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 932677010536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677010537 active site 932677010538 intermolecular recognition site; other site 932677010539 dimerization interface [polypeptide binding]; other site 932677010540 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932677010541 DNA binding site [nucleotide binding] 932677010542 two-component sensor protein; Provisional; Region: cpxA; PRK09470 932677010543 HAMP domain; Region: HAMP; pfam00672 932677010544 dimerization interface [polypeptide binding]; other site 932677010545 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 932677010546 dimer interface [polypeptide binding]; other site 932677010547 phosphorylation site [posttranslational modification] 932677010548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677010549 ATP binding site [chemical binding]; other site 932677010550 Mg2+ binding site [ion binding]; other site 932677010551 G-X-G motif; other site 932677010552 putative rRNA methylase; Provisional; Region: PRK10358 932677010553 serine acetyltransferase; Provisional; Region: cysE; PRK11132 932677010554 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 932677010555 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 932677010556 trimer interface [polypeptide binding]; other site 932677010557 active site 932677010558 substrate binding site [chemical binding]; other site 932677010559 CoA binding site [chemical binding]; other site 932677010560 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 932677010561 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 932677010562 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 932677010563 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 932677010564 SecA binding site; other site 932677010565 Preprotein binding site; other site 932677010566 potential protein location (hypothetical protein) that overlaps protein (protein-export protein SecB) 932677010567 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 932677010568 GSH binding site [chemical binding]; other site 932677010569 catalytic residues [active] 932677010570 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 932677010571 active site residue [active] 932677010572 AmiB activator; Provisional; Region: PRK11637 932677010573 Peptidase family M23; Region: Peptidase_M23; pfam01551 932677010574 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 932677010575 putative active site [active] 932677010576 NodB motif; other site 932677010577 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 932677010578 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 932677010579 NAD(P) binding site [chemical binding]; other site 932677010580 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 932677010581 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 932677010582 substrate-cofactor binding pocket; other site 932677010583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677010584 catalytic residue [active] 932677010585 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 932677010586 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 932677010587 NADP binding site [chemical binding]; other site 932677010588 homopentamer interface [polypeptide binding]; other site 932677010589 substrate binding site [chemical binding]; other site 932677010590 active site 932677010591 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 932677010592 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 932677010593 putative active site [active] 932677010594 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 932677010595 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 932677010596 putative active site [active] 932677010597 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 932677010598 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 932677010599 putative glycosyl transferase; Provisional; Region: PRK10073 932677010600 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 932677010601 active site 932677010602 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 932677010603 putative active site [active] 932677010604 putative catalytic site [active] 932677010605 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 932677010606 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 932677010607 putative ADP-binding pocket [chemical binding]; other site 932677010608 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 932677010609 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 932677010610 putative active site [active] 932677010611 putative glycosyl transferase; Provisional; Region: PRK10073 932677010612 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 932677010613 active site 932677010614 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 932677010615 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 932677010616 putative active site [active] 932677010617 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 932677010618 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 932677010619 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 932677010620 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 932677010621 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 932677010622 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 932677010623 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 932677010624 putative metal binding site; other site 932677010625 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 932677010626 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 932677010627 active site 932677010628 (T/H)XGH motif; other site 932677010629 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 932677010630 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 932677010631 DNA binding site [nucleotide binding] 932677010632 catalytic residue [active] 932677010633 H2TH interface [polypeptide binding]; other site 932677010634 putative catalytic residues [active] 932677010635 turnover-facilitating residue; other site 932677010636 intercalation triad [nucleotide binding]; other site 932677010637 8OG recognition residue [nucleotide binding]; other site 932677010638 putative reading head residues; other site 932677010639 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 932677010640 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 932677010641 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 932677010642 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 932677010643 hypothetical protein; Reviewed; Region: PRK00024 932677010644 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 932677010645 MPN+ (JAMM) motif; other site 932677010646 Zinc-binding site [ion binding]; other site 932677010647 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 932677010648 Flavoprotein; Region: Flavoprotein; pfam02441 932677010649 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 932677010650 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 932677010651 trimer interface [polypeptide binding]; other site 932677010652 active site 932677010653 division inhibitor protein; Provisional; Region: slmA; PRK09480 932677010654 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932677010655 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 932677010656 active site 932677010657 ribonuclease PH; Reviewed; Region: rph; PRK00173 932677010658 Ribonuclease PH; Region: RNase_PH_bact; cd11362 932677010659 hexamer interface [polypeptide binding]; other site 932677010660 active site 932677010661 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 932677010662 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 932677010663 Nucleoside recognition; Region: Gate; pfam07670 932677010664 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 932677010665 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 932677010666 hypothetical protein; Provisional; Region: PRK11820 932677010667 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 932677010668 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 932677010669 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 932677010670 Catalytic domain of Protein Kinases; Region: PKc; cd00180 932677010671 active site 932677010672 ATP binding site [chemical binding]; other site 932677010673 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 932677010674 substrate binding site [chemical binding]; other site 932677010675 activation loop (A-loop); other site 932677010676 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 932677010677 Catalytic domain of Protein Kinases; Region: PKc; cd00180 932677010678 active site 932677010679 ATP binding site [chemical binding]; other site 932677010680 substrate binding site [chemical binding]; other site 932677010681 activation loop (A-loop); other site 932677010682 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 932677010683 RNA binding site [nucleotide binding]; other site 932677010684 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 932677010685 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 932677010686 putative acyl-acceptor binding pocket; other site 932677010687 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 932677010688 Predicted membrane protein [Function unknown]; Region: COG2860 932677010689 UPF0126 domain; Region: UPF0126; pfam03458 932677010690 UPF0126 domain; Region: UPF0126; pfam03458 932677010691 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 932677010692 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 932677010693 nucleotide binding pocket [chemical binding]; other site 932677010694 K-X-D-G motif; other site 932677010695 catalytic site [active] 932677010696 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 932677010697 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 932677010698 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 932677010699 catalytic site [active] 932677010700 G-X2-G-X-G-K; other site 932677010701 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 932677010702 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 932677010703 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932677010704 Zn2+ binding site [ion binding]; other site 932677010705 Mg2+ binding site [ion binding]; other site 932677010706 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 932677010707 synthetase active site [active] 932677010708 NTP binding site [chemical binding]; other site 932677010709 metal binding site [ion binding]; metal-binding site 932677010710 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 932677010711 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 932677010712 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 932677010713 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 932677010714 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 932677010715 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 932677010716 Y-family of DNA polymerases; Region: PolY; cl12025 932677010717 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 932677010718 generic binding surface II; other site 932677010719 ssDNA binding site; other site 932677010720 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932677010721 ATP binding site [chemical binding]; other site 932677010722 putative Mg++ binding site [ion binding]; other site 932677010723 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932677010724 nucleotide binding region [chemical binding]; other site 932677010725 ATP-binding site [chemical binding]; other site 932677010726 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 932677010727 AsmA family; Region: AsmA; pfam05170 932677010728 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 932677010729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677010730 Coenzyme A binding pocket [chemical binding]; other site 932677010731 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 932677010732 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 932677010733 putative active site [active] 932677010734 dimerization interface [polypeptide binding]; other site 932677010735 putative tRNAtyr binding site [nucleotide binding]; other site 932677010736 hypothetical protein; Reviewed; Region: PRK01637 932677010737 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 932677010738 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677010739 motif II; other site 932677010740 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 932677010741 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 932677010742 G2 box; other site 932677010743 Switch I region; other site 932677010744 G3 box; other site 932677010745 Switch II region; other site 932677010746 GTP/Mg2+ binding site [chemical binding]; other site 932677010747 G4 box; other site 932677010748 G5 box; other site 932677010749 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 932677010750 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 932677010751 glutamine synthetase; Provisional; Region: glnA; PRK09469 932677010752 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 932677010753 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 932677010754 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 932677010755 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932677010756 putative active site [active] 932677010757 heme pocket [chemical binding]; other site 932677010758 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932677010759 dimer interface [polypeptide binding]; other site 932677010760 phosphorylation site [posttranslational modification] 932677010761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677010762 ATP binding site [chemical binding]; other site 932677010763 Mg2+ binding site [ion binding]; other site 932677010764 G-X-G motif; other site 932677010765 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 932677010766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677010767 active site 932677010768 phosphorylation site [posttranslational modification] 932677010769 intermolecular recognition site; other site 932677010770 dimerization interface [polypeptide binding]; other site 932677010771 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677010772 Walker A motif; other site 932677010773 ATP binding site [chemical binding]; other site 932677010774 Walker B motif; other site 932677010775 arginine finger; other site 932677010776 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 932677010777 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 932677010778 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 932677010779 FeS/SAM binding site; other site 932677010780 HemN C-terminal domain; Region: HemN_C; pfam06969 932677010781 Der GTPase activator; Provisional; Region: PRK05244 932677010782 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 932677010783 G1 box; other site 932677010784 GTP/Mg2+ binding site [chemical binding]; other site 932677010785 Switch I region; other site 932677010786 G2 box; other site 932677010787 G3 box; other site 932677010788 Switch II region; other site 932677010789 G4 box; other site 932677010790 G5 box; other site 932677010791 DNA polymerase I; Provisional; Region: PRK05755 932677010792 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 932677010793 active site 932677010794 metal binding site 1 [ion binding]; metal-binding site 932677010795 putative 5' ssDNA interaction site; other site 932677010796 metal binding site 3; metal-binding site 932677010797 metal binding site 2 [ion binding]; metal-binding site 932677010798 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 932677010799 putative DNA binding site [nucleotide binding]; other site 932677010800 putative metal binding site [ion binding]; other site 932677010801 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 932677010802 active site 932677010803 catalytic site [active] 932677010804 substrate binding site [chemical binding]; other site 932677010805 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 932677010806 active site 932677010807 DNA binding site [nucleotide binding] 932677010808 catalytic site [active] 932677010809 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 932677010810 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 932677010811 catalytic residues [active] 932677010812 hinge region; other site 932677010813 alpha helical domain; other site 932677010814 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 932677010815 serine/threonine protein kinase; Provisional; Region: PRK11768 932677010816 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 932677010817 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 932677010818 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 932677010819 GTP binding site; other site 932677010820 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 932677010821 Walker A motif; other site 932677010822 potential protein location (hypothetical protein PAJ_3164 [Pantoea ananatis AJ13355]) that overlaps RNA (5S ribosomal RNA) 932677010823 putative transporter; Provisional; Region: PRK10504 932677010824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677010825 putative substrate translocation pore; other site 932677010826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677010827 transcriptional repressor RbsR; Provisional; Region: PRK10423 932677010828 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932677010829 DNA binding site [nucleotide binding] 932677010830 domain linker motif; other site 932677010831 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 932677010832 dimerization interface [polypeptide binding]; other site 932677010833 ligand binding site [chemical binding]; other site 932677010834 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 932677010835 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 932677010836 substrate binding site [chemical binding]; other site 932677010837 dimer interface [polypeptide binding]; other site 932677010838 ATP binding site [chemical binding]; other site 932677010839 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 932677010840 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 932677010841 ligand binding site [chemical binding]; other site 932677010842 dimerization interface [polypeptide binding]; other site 932677010843 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932677010844 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 932677010845 TM-ABC transporter signature motif; other site 932677010846 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 932677010847 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 932677010848 Walker A/P-loop; other site 932677010849 ATP binding site [chemical binding]; other site 932677010850 Q-loop/lid; other site 932677010851 ABC transporter signature motif; other site 932677010852 Walker B; other site 932677010853 D-loop; other site 932677010854 H-loop/switch region; other site 932677010855 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 932677010856 D-ribose pyranase; Provisional; Region: PRK11797 932677010857 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 932677010858 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 932677010859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677010860 active site 932677010861 phosphorylation site [posttranslational modification] 932677010862 intermolecular recognition site; other site 932677010863 dimerization interface [polypeptide binding]; other site 932677010864 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932677010865 DNA binding site [nucleotide binding] 932677010866 sensor protein QseC; Provisional; Region: PRK10337 932677010867 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932677010868 dimer interface [polypeptide binding]; other site 932677010869 phosphorylation site [posttranslational modification] 932677010870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677010871 ATP binding site [chemical binding]; other site 932677010872 Mg2+ binding site [ion binding]; other site 932677010873 G-X-G motif; other site 932677010874 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 932677010875 potassium uptake protein; Region: kup; TIGR00794 932677010876 regulatory ATPase RavA; Provisional; Region: PRK13531 932677010877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677010878 Walker A motif; other site 932677010879 ATP binding site [chemical binding]; other site 932677010880 Walker B motif; other site 932677010881 arginine finger; other site 932677010882 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 932677010883 hypothetical protein; Provisional; Region: yieM; PRK10997 932677010884 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 932677010885 metal ion-dependent adhesion site (MIDAS); other site 932677010886 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 932677010887 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 932677010888 Methyltransferase domain; Region: Methyltransf_31; pfam13847 932677010889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677010890 S-adenosylmethionine binding site [chemical binding]; other site 932677010891 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 932677010892 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932677010893 putative DNA binding site [nucleotide binding]; other site 932677010894 putative Zn2+ binding site [ion binding]; other site 932677010895 AsnC family; Region: AsnC_trans_reg; pfam01037 932677010896 FMN-binding protein MioC; Provisional; Region: PRK09004 932677010897 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 932677010898 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 932677010899 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 932677010900 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 932677010901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677010902 S-adenosylmethionine binding site [chemical binding]; other site 932677010903 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 932677010904 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 932677010905 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 932677010906 ATP synthase, F0 subunit c; Region: ATP_synt_c; TIGR01260 932677010907 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 932677010908 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 932677010909 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 932677010910 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 932677010911 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 932677010912 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 932677010913 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 932677010914 Walker A motif; other site 932677010915 ATP binding site [chemical binding]; other site 932677010916 Walker B motif; other site 932677010917 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 932677010918 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 932677010919 core domain interface [polypeptide binding]; other site 932677010920 delta subunit interface [polypeptide binding]; other site 932677010921 epsilon subunit interface [polypeptide binding]; other site 932677010922 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 932677010923 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 932677010924 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 932677010925 alpha subunit interaction interface [polypeptide binding]; other site 932677010926 Walker A motif; other site 932677010927 ATP binding site [chemical binding]; other site 932677010928 Walker B motif; other site 932677010929 inhibitor binding site; inhibition site 932677010930 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 932677010931 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 932677010932 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 932677010933 gamma subunit interface [polypeptide binding]; other site 932677010934 epsilon subunit interface [polypeptide binding]; other site 932677010935 LBP interface [polypeptide binding]; other site 932677010936 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 932677010937 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 932677010938 Substrate binding site; other site 932677010939 Mg++ binding site; other site 932677010940 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 932677010941 active site 932677010942 substrate binding site [chemical binding]; other site 932677010943 CoA binding site [chemical binding]; other site 932677010944 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 932677010945 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 932677010946 glutaminase active site [active] 932677010947 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 932677010948 dimer interface [polypeptide binding]; other site 932677010949 active site 932677010950 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 932677010951 dimer interface [polypeptide binding]; other site 932677010952 active site 932677010953 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677010954 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 932677010955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677010956 dimer interface [polypeptide binding]; other site 932677010957 conserved gate region; other site 932677010958 putative PBP binding loops; other site 932677010959 ABC-ATPase subunit interface; other site 932677010960 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 932677010961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677010962 dimer interface [polypeptide binding]; other site 932677010963 conserved gate region; other site 932677010964 putative PBP binding loops; other site 932677010965 ABC-ATPase subunit interface; other site 932677010966 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 932677010967 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 932677010968 Walker A/P-loop; other site 932677010969 ATP binding site [chemical binding]; other site 932677010970 Q-loop/lid; other site 932677010971 ABC transporter signature motif; other site 932677010972 Walker B; other site 932677010973 D-loop; other site 932677010974 H-loop/switch region; other site 932677010975 transcriptional regulator PhoU; Provisional; Region: PRK11115 932677010976 PhoU domain; Region: PhoU; pfam01895 932677010977 PhoU domain; Region: PhoU; pfam01895 932677010978 benzoate transport; Region: 2A0115; TIGR00895 932677010979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677010980 putative substrate translocation pore; other site 932677010981 xylulokinase; Provisional; Region: PRK15027 932677010982 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 932677010983 N- and C-terminal domain interface [polypeptide binding]; other site 932677010984 active site 932677010985 MgATP binding site [chemical binding]; other site 932677010986 catalytic site [active] 932677010987 metal binding site [ion binding]; metal-binding site 932677010988 xylulose binding site [chemical binding]; other site 932677010989 homodimer interface [polypeptide binding]; other site 932677010990 xylose isomerase; Provisional; Region: PRK05474 932677010991 xylose isomerase; Region: xylose_isom_A; TIGR02630 932677010992 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 932677010993 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 932677010994 putative ligand binding site [chemical binding]; other site 932677010995 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 932677010996 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 932677010997 Walker A/P-loop; other site 932677010998 ATP binding site [chemical binding]; other site 932677010999 Q-loop/lid; other site 932677011000 ABC transporter signature motif; other site 932677011001 Walker B; other site 932677011002 D-loop; other site 932677011003 H-loop/switch region; other site 932677011004 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 932677011005 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 932677011006 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932677011007 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 932677011008 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 932677011009 TM-ABC transporter signature motif; other site 932677011010 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 932677011011 putative dimerization interface [polypeptide binding]; other site 932677011012 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932677011013 putative ligand binding site [chemical binding]; other site 932677011014 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677011015 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 932677011016 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677011017 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 932677011018 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677011019 Coenzyme A binding pocket [chemical binding]; other site 932677011020 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 932677011021 active site 932677011022 catalytic residues [active] 932677011023 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 932677011024 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 932677011025 ligand binding site [chemical binding]; other site 932677011026 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 932677011027 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 932677011028 Walker A/P-loop; other site 932677011029 ATP binding site [chemical binding]; other site 932677011030 Q-loop/lid; other site 932677011031 ABC transporter signature motif; other site 932677011032 Walker B; other site 932677011033 D-loop; other site 932677011034 H-loop/switch region; other site 932677011035 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 932677011036 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932677011037 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 932677011038 TM-ABC transporter signature motif; other site 932677011039 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 932677011040 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932677011041 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932677011042 putative active site [active] 932677011043 OsmC-like protein; Region: OsmC; cl00767 932677011044 H+ Antiporter protein; Region: 2A0121; TIGR00900 932677011045 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 932677011046 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cl00723 932677011047 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932677011048 PAS domain; Region: PAS_9; pfam13426 932677011049 putative active site [active] 932677011050 heme pocket [chemical binding]; other site 932677011051 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932677011052 PAS domain; Region: PAS_9; pfam13426 932677011053 putative active site [active] 932677011054 heme pocket [chemical binding]; other site 932677011055 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677011056 dimer interface [polypeptide binding]; other site 932677011057 putative CheW interface [polypeptide binding]; other site 932677011058 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677011059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677011060 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 932677011061 putative dimerization interface [polypeptide binding]; other site 932677011062 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 932677011063 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 932677011064 citrate-proton symporter; Provisional; Region: PRK15075 932677011065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677011066 putative substrate translocation pore; other site 932677011067 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 932677011068 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 932677011069 methionine cluster; other site 932677011070 active site 932677011071 phosphorylation site [posttranslational modification] 932677011072 metal binding site [ion binding]; metal-binding site 932677011073 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 932677011074 beta-galactosidase; Region: BGL; TIGR03356 932677011075 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 932677011076 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 932677011077 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 932677011078 active site 932677011079 P-loop; other site 932677011080 phosphorylation site [posttranslational modification] 932677011081 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932677011082 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932677011083 DNA binding site [nucleotide binding] 932677011084 domain linker motif; other site 932677011085 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 932677011086 ligand binding site [chemical binding]; other site 932677011087 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932677011088 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 932677011089 DNA replication protein DnaC; Validated; Region: PRK07952 932677011090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677011091 Walker A motif; other site 932677011092 ATP binding site [chemical binding]; other site 932677011093 Walker B motif; other site 932677011094 primosomal protein DnaI; Provisional; Region: PRK02854 932677011095 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 932677011096 putative outer membrane lipoprotein; Provisional; Region: PRK10510 932677011097 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 932677011098 ligand binding site [chemical binding]; other site 932677011099 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932677011100 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932677011101 DNA binding site [nucleotide binding] 932677011102 domain linker motif; other site 932677011103 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 932677011104 ligand binding site [chemical binding]; other site 932677011105 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932677011106 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932677011107 DNA binding site [nucleotide binding] 932677011108 domain linker motif; other site 932677011109 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 932677011110 putative dimerization interface [polypeptide binding]; other site 932677011111 putative ligand binding site [chemical binding]; other site 932677011112 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 932677011113 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 932677011114 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 932677011115 substrate binding site [chemical binding]; other site 932677011116 ATP binding site [chemical binding]; other site 932677011117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677011118 D-galactonate transporter; Region: 2A0114; TIGR00893 932677011119 putative substrate translocation pore; other site 932677011120 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 932677011121 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 932677011122 dimerization interface [polypeptide binding]; other site 932677011123 ligand binding site [chemical binding]; other site 932677011124 NADP binding site [chemical binding]; other site 932677011125 catalytic site [active] 932677011126 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 932677011127 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932677011128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677011129 homodimer interface [polypeptide binding]; other site 932677011130 catalytic residue [active] 932677011131 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 932677011132 EamA-like transporter family; Region: EamA; pfam00892 932677011133 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 932677011134 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 932677011135 active site 932677011136 Uncharacterized conserved protein [Function unknown]; Region: COG5464 932677011137 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 932677011138 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 932677011139 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 932677011140 putative dimer interface [polypeptide binding]; other site 932677011141 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 932677011142 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 932677011143 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 932677011144 sugar phosphate phosphatase; Provisional; Region: PRK10513 932677011145 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677011146 active site 932677011147 motif I; other site 932677011148 motif II; other site 932677011149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677011150 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 932677011151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677011152 Mg2+ binding site [ion binding]; other site 932677011153 G-X-G motif; other site 932677011154 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 932677011155 anchoring element; other site 932677011156 dimer interface [polypeptide binding]; other site 932677011157 ATP binding site [chemical binding]; other site 932677011158 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 932677011159 active site 932677011160 putative metal-binding site [ion binding]; other site 932677011161 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 932677011162 recF protein; Region: recf; TIGR00611 932677011163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677011164 Walker A/P-loop; other site 932677011165 ATP binding site [chemical binding]; other site 932677011166 Q-loop/lid; other site 932677011167 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677011168 ABC transporter signature motif; other site 932677011169 Walker B; other site 932677011170 D-loop; other site 932677011171 H-loop/switch region; other site 932677011172 DNA polymerase III subunit beta; Validated; Region: PRK05643 932677011173 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 932677011174 putative DNA binding surface [nucleotide binding]; other site 932677011175 dimer interface [polypeptide binding]; other site 932677011176 beta-clamp/clamp loader binding surface; other site 932677011177 beta-clamp/translesion DNA polymerase binding surface; other site 932677011178 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 932677011179 DnaA N-terminal domain; Region: DnaA_N; pfam11638 932677011180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677011181 Walker A motif; other site 932677011182 ATP binding site [chemical binding]; other site 932677011183 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 932677011184 Walker B motif; other site 932677011185 arginine finger; other site 932677011186 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 932677011187 DnaA box-binding interface [nucleotide binding]; other site 932677011188 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 932677011189 ribonuclease P; Reviewed; Region: rnpA; PRK01732 932677011190 membrane protein insertase; Provisional; Region: PRK01318 932677011191 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 932677011192 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 932677011193 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 932677011194 trmE is a tRNA modification GTPase; Region: trmE; cd04164 932677011195 G1 box; other site 932677011196 GTP/Mg2+ binding site [chemical binding]; other site 932677011197 Switch I region; other site 932677011198 G2 box; other site 932677011199 Switch II region; other site 932677011200 G3 box; other site 932677011201 G4 box; other site 932677011202 G5 box; other site 932677011203 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 932677011204 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 932677011205 putative FMN binding site [chemical binding]; other site 932677011206 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 932677011207 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 932677011208 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 932677011209 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 932677011210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677011211 active site 932677011212 motif I; other site 932677011213 motif II; other site 932677011214 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 932677011215 Acyltransferase family; Region: Acyl_transf_3; pfam01757 932677011216 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 932677011217 dimer interface [polypeptide binding]; other site 932677011218 motif 1; other site 932677011219 active site 932677011220 motif 2; other site 932677011221 motif 3; other site 932677011222 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 932677011223 DALR anticodon binding domain; Region: DALR_1; pfam05746 932677011224 potential protein location (hypothetical protein) that overlaps protein (glycyl-tRNA synthetase beta chain GlyS) 932677011225 MltA-interacting protein MipA; Region: MipA; cl01504 932677011226 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 932677011227 putative glutathione S-transferase; Provisional; Region: PRK10357 932677011228 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 932677011229 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 932677011230 dimer interface [polypeptide binding]; other site 932677011231 N-terminal domain interface [polypeptide binding]; other site 932677011232 putative substrate binding pocket (H-site) [chemical binding]; other site 932677011233 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 932677011234 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 932677011235 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 932677011236 superoxide dismutase; Provisional; Region: PRK10925 932677011237 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 932677011238 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 932677011239 Protein of unknown function (DUF535); Region: DUF535; pfam04393 932677011240 hypothetical protein; Provisional; Region: PRK11020 932677011241 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 932677011242 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 932677011243 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 932677011244 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 932677011245 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 932677011246 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 932677011247 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 932677011248 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 932677011249 active site 932677011250 P-loop; other site 932677011251 phosphorylation site [posttranslational modification] 932677011252 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932677011253 active site 932677011254 phosphorylation site [posttranslational modification] 932677011255 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 932677011256 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932677011257 non-specific DNA binding site [nucleotide binding]; other site 932677011258 salt bridge; other site 932677011259 sequence-specific DNA binding site [nucleotide binding]; other site 932677011260 tryptophan permease TnaB; Provisional; Region: PRK09664 932677011261 aromatic amino acid transport protein; Region: araaP; TIGR00837 932677011262 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 932677011263 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 932677011264 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932677011265 catalytic residue [active] 932677011266 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 932677011267 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 932677011268 Zn2+ binding site [ion binding]; other site 932677011269 Mg2+ binding site [ion binding]; other site 932677011270 Transcriptional regulators [Transcription]; Region: MarR; COG1846 932677011271 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932677011272 putative Zn2+ binding site [ion binding]; other site 932677011273 putative DNA binding site [nucleotide binding]; other site 932677011274 phosphoethanolamine transferase; Provisional; Region: PRK11560 932677011275 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 932677011276 Sulfatase; Region: Sulfatase; pfam00884 932677011277 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 932677011278 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 932677011279 peptide binding site [polypeptide binding]; other site 932677011280 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 932677011281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677011282 dimer interface [polypeptide binding]; other site 932677011283 conserved gate region; other site 932677011284 putative PBP binding loops; other site 932677011285 ABC-ATPase subunit interface; other site 932677011286 dipeptide transporter; Provisional; Region: PRK10913 932677011287 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 932677011288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677011289 dimer interface [polypeptide binding]; other site 932677011290 conserved gate region; other site 932677011291 putative PBP binding loops; other site 932677011292 ABC-ATPase subunit interface; other site 932677011293 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 932677011294 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932677011295 Walker A/P-loop; other site 932677011296 ATP binding site [chemical binding]; other site 932677011297 Q-loop/lid; other site 932677011298 ABC transporter signature motif; other site 932677011299 Walker B; other site 932677011300 D-loop; other site 932677011301 H-loop/switch region; other site 932677011302 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 932677011303 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 932677011304 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932677011305 Walker A/P-loop; other site 932677011306 ATP binding site [chemical binding]; other site 932677011307 Q-loop/lid; other site 932677011308 ABC transporter signature motif; other site 932677011309 Walker B; other site 932677011310 D-loop; other site 932677011311 H-loop/switch region; other site 932677011312 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 932677011313 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 932677011314 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 932677011315 P-loop; other site 932677011316 Magnesium ion binding site [ion binding]; other site 932677011317 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 932677011318 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 932677011319 DXD motif; other site 932677011320 PilZ domain; Region: PilZ; pfam07238 932677011321 cellulose synthase regulator protein; Provisional; Region: PRK11114 932677011322 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 932677011323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932677011324 binding surface 932677011325 TPR motif; other site 932677011326 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 932677011327 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 932677011328 putative diguanylate cyclase; Provisional; Region: PRK13561 932677011329 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932677011330 metal binding site [ion binding]; metal-binding site 932677011331 active site 932677011332 I-site; other site 932677011333 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932677011334 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 932677011335 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 932677011336 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 932677011337 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 932677011338 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 932677011339 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 932677011340 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932677011341 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 932677011342 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 932677011343 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 932677011344 substrate binding site [chemical binding]; other site 932677011345 ATP binding site [chemical binding]; other site 932677011346 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932677011347 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 932677011348 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 932677011349 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 932677011350 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 932677011351 Part of AAA domain; Region: AAA_19; pfam13245 932677011352 Family description; Region: UvrD_C_2; pfam13538 932677011353 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 932677011354 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 932677011355 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 932677011356 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 932677011357 ATP binding site [chemical binding]; other site 932677011358 Mg++ binding site [ion binding]; other site 932677011359 motif III; other site 932677011360 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932677011361 nucleotide binding region [chemical binding]; other site 932677011362 ATP-binding site [chemical binding]; other site 932677011363 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 932677011364 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 932677011365 catalytic residues [active] 932677011366 transcription termination factor Rho; Provisional; Region: rho; PRK09376 932677011367 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 932677011368 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 932677011369 RNA binding site [nucleotide binding]; other site 932677011370 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 932677011371 multimer interface [polypeptide binding]; other site 932677011372 Walker A motif; other site 932677011373 ATP binding site [chemical binding]; other site 932677011374 Walker B motif; other site 932677011375 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 932677011376 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 932677011377 Mg++ binding site [ion binding]; other site 932677011378 putative catalytic motif [active] 932677011379 substrate binding site [chemical binding]; other site 932677011380 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 932677011381 Chain length determinant protein; Region: Wzz; pfam02706 932677011382 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 932677011383 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 932677011384 homodimer interface [polypeptide binding]; other site 932677011385 active site 932677011386 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 932677011387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 932677011388 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 932677011389 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 932677011390 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 932677011391 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 932677011392 NAD binding site [chemical binding]; other site 932677011393 substrate binding site [chemical binding]; other site 932677011394 homodimer interface [polypeptide binding]; other site 932677011395 active site 932677011396 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 932677011397 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 932677011398 substrate binding site; other site 932677011399 tetramer interface; other site 932677011400 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 932677011401 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677011402 Coenzyme A binding pocket [chemical binding]; other site 932677011403 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 932677011404 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 932677011405 inhibitor-cofactor binding pocket; inhibition site 932677011406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677011407 catalytic residue [active] 932677011408 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 932677011409 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 932677011410 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929 932677011411 putative common antigen polymerase; Provisional; Region: PRK02975 932677011412 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 932677011413 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 932677011414 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 932677011415 HemY protein N-terminus; Region: HemY_N; pfam07219 932677011416 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 932677011417 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 932677011418 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 932677011419 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 932677011420 active site 932677011421 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 932677011422 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 932677011423 domain interfaces; other site 932677011424 active site 932677011425 adenylate cyclase; Provisional; Region: cyaA; PRK09450 932677011426 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 932677011427 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 932677011428 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 932677011429 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 932677011430 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 932677011431 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 932677011432 hypothetical protein; Provisional; Region: PRK10963 932677011433 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 932677011434 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 932677011435 active site 932677011436 DNA binding site [nucleotide binding] 932677011437 Int/Topo IB signature motif; other site 932677011438 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 932677011439 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677011440 motif II; other site 932677011441 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 932677011442 Part of AAA domain; Region: AAA_19; pfam13245 932677011443 Family description; Region: UvrD_C_2; pfam13538 932677011444 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 932677011445 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 932677011446 Cl binding site [ion binding]; other site 932677011447 oligomer interface [polypeptide binding]; other site 932677011448 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 932677011449 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 932677011450 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 932677011451 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 932677011452 Predicted transcriptional regulators [Transcription]; Region: COG1733 932677011453 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 932677011454 dimerization interface [polypeptide binding]; other site 932677011455 putative DNA binding site [nucleotide binding]; other site 932677011456 putative Zn2+ binding site [ion binding]; other site 932677011457 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 932677011458 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 932677011459 CoenzymeA binding site [chemical binding]; other site 932677011460 subunit interaction site [polypeptide binding]; other site 932677011461 PHB binding site; other site 932677011462 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248 932677011463 dimerization interface [polypeptide binding]; other site 932677011464 substrate binding site [chemical binding]; other site 932677011465 active site 932677011466 calcium binding site [ion binding]; other site 932677011467 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 932677011468 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932677011469 ATP binding site [chemical binding]; other site 932677011470 putative Mg++ binding site [ion binding]; other site 932677011471 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932677011472 nucleotide binding region [chemical binding]; other site 932677011473 ATP-binding site [chemical binding]; other site 932677011474 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 932677011475 HRDC domain; Region: HRDC; pfam00570 932677011476 threonine efflux system; Provisional; Region: PRK10229 932677011477 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 932677011478 lysophospholipase L2; Provisional; Region: PRK10749 932677011479 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 932677011480 putative hydrolase; Provisional; Region: PRK10976 932677011481 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677011482 active site 932677011483 motif I; other site 932677011484 motif II; other site 932677011485 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677011486 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 932677011487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677011488 putative substrate translocation pore; other site 932677011489 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 932677011490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 932677011491 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 932677011492 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 932677011493 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 932677011494 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677011495 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 932677011496 putative dimerization interface [polypeptide binding]; other site 932677011497 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 932677011498 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 932677011499 THF binding site; other site 932677011500 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 932677011501 substrate binding site [chemical binding]; other site 932677011502 THF binding site; other site 932677011503 zinc-binding site [ion binding]; other site 932677011504 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 932677011505 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 932677011506 uridine phosphorylase; Provisional; Region: PRK11178 932677011507 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 932677011508 DNA recombination protein RmuC; Provisional; Region: PRK10361 932677011509 RmuC family; Region: RmuC; pfam02646 932677011510 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 932677011511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677011512 S-adenosylmethionine binding site [chemical binding]; other site 932677011513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 932677011514 SCP-2 sterol transfer family; Region: SCP2; pfam02036 932677011515 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 932677011516 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 932677011517 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 932677011518 sec-independent translocase; Provisional; Region: PRK01770 932677011519 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 932677011520 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 932677011521 active site 932677011522 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 932677011523 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 932677011524 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 932677011525 FMN reductase; Validated; Region: fre; PRK08051 932677011526 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 932677011527 FAD binding pocket [chemical binding]; other site 932677011528 FAD binding motif [chemical binding]; other site 932677011529 phosphate binding motif [ion binding]; other site 932677011530 beta-alpha-beta structure motif; other site 932677011531 NAD binding pocket [chemical binding]; other site 932677011532 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 932677011533 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 932677011534 dimer interface [polypeptide binding]; other site 932677011535 active site 932677011536 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 932677011537 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 932677011538 substrate binding site [chemical binding]; other site 932677011539 oxyanion hole (OAH) forming residues; other site 932677011540 trimer interface [polypeptide binding]; other site 932677011541 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 932677011542 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 932677011543 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 932677011544 proline dipeptidase; Provisional; Region: PRK13607 932677011545 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 932677011546 active site 932677011547 hypothetical protein; Provisional; Region: PRK11568 932677011548 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 932677011549 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 932677011550 potassium transporter; Provisional; Region: PRK10750 932677011551 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 932677011552 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 932677011553 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 932677011554 FAD binding domain; Region: FAD_binding_4; pfam01565 932677011555 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 932677011556 Biotin operon repressor [Transcription]; Region: BirA; COG1654 932677011557 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 932677011558 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 932677011559 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 932677011560 pantothenate kinase; Provisional; Region: PRK05439 932677011561 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 932677011562 ATP-binding site [chemical binding]; other site 932677011563 CoA-binding site [chemical binding]; other site 932677011564 Mg2+-binding site [ion binding]; other site 932677011565 elongation factor Tu; Reviewed; Region: PRK00049 932677011566 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 932677011567 G1 box; other site 932677011568 GEF interaction site [polypeptide binding]; other site 932677011569 GTP/Mg2+ binding site [chemical binding]; other site 932677011570 Switch I region; other site 932677011571 G2 box; other site 932677011572 G3 box; other site 932677011573 Switch II region; other site 932677011574 G4 box; other site 932677011575 G5 box; other site 932677011576 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 932677011577 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 932677011578 Antibiotic Binding Site [chemical binding]; other site 932677011579 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 932677011580 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 932677011581 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 932677011582 putative homodimer interface [polypeptide binding]; other site 932677011583 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 932677011584 heterodimer interface [polypeptide binding]; other site 932677011585 homodimer interface [polypeptide binding]; other site 932677011586 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 932677011587 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 932677011588 23S rRNA interface [nucleotide binding]; other site 932677011589 L7/L12 interface [polypeptide binding]; other site 932677011590 putative thiostrepton binding site; other site 932677011591 L25 interface [polypeptide binding]; other site 932677011592 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 932677011593 mRNA/rRNA interface [nucleotide binding]; other site 932677011594 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 932677011595 23S rRNA interface [nucleotide binding]; other site 932677011596 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 932677011597 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 932677011598 L11 interface [polypeptide binding]; other site 932677011599 putative EF-Tu interaction site [polypeptide binding]; other site 932677011600 putative EF-G interaction site [polypeptide binding]; other site 932677011601 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 932677011602 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 932677011603 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 932677011604 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 932677011605 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 932677011606 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 932677011607 RPB3 interaction site [polypeptide binding]; other site 932677011608 RPB1 interaction site [polypeptide binding]; other site 932677011609 RPB11 interaction site [polypeptide binding]; other site 932677011610 RPB10 interaction site [polypeptide binding]; other site 932677011611 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 932677011612 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 932677011613 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 932677011614 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 932677011615 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 932677011616 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 932677011617 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 932677011618 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 932677011619 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 932677011620 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 932677011621 DNA binding site [nucleotide binding] 932677011622 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 932677011623 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 932677011624 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932677011625 DNA-binding site [nucleotide binding]; DNA binding site 932677011626 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932677011627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677011628 homodimer interface [polypeptide binding]; other site 932677011629 catalytic residue [active] 932677011630 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 932677011631 pyrophosphate binding site [ion binding]; other site 932677011632 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 932677011633 ThiC-associated domain; Region: ThiC-associated; pfam13667 932677011634 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 932677011635 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 932677011636 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 932677011637 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 932677011638 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 932677011639 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 932677011640 putative NADH binding site [chemical binding]; other site 932677011641 putative active site [active] 932677011642 nudix motif; other site 932677011643 putative metal binding site [ion binding]; other site 932677011644 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 932677011645 substrate binding site [chemical binding]; other site 932677011646 active site 932677011647 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 932677011648 Active_site [active] 932677011649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 932677011650 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 932677011651 IHF dimer interface [polypeptide binding]; other site 932677011652 IHF - DNA interface [nucleotide binding]; other site 932677011653 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 932677011654 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 932677011655 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 932677011656 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 932677011657 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 932677011658 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 932677011659 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 932677011660 purine monophosphate binding site [chemical binding]; other site 932677011661 dimer interface [polypeptide binding]; other site 932677011662 putative catalytic residues [active] 932677011663 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 932677011664 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 932677011665 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 932677011666 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 932677011667 putative ligand binding residues [chemical binding]; other site 932677011668 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 932677011669 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 932677011670 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 932677011671 homoserine O-succinyltransferase; Provisional; Region: PRK05368 932677011672 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 932677011673 proposed active site lysine [active] 932677011674 conserved cys residue [active] 932677011675 malate synthase A; Region: malate_syn_A; TIGR01344 932677011676 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 932677011677 active site 932677011678 isocitrate lyase; Provisional; Region: PRK15063 932677011679 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 932677011680 tetramer interface [polypeptide binding]; other site 932677011681 active site 932677011682 Mg2+/Mn2+ binding site [ion binding]; other site 932677011683 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 932677011684 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 932677011685 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 932677011686 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932677011687 DNA-binding site [nucleotide binding]; DNA binding site 932677011688 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 932677011689 putative outer membrane porin protein; Provisional; Region: PRK11379 932677011690 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 932677011691 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 932677011692 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 932677011693 Beta-lactamase; Region: Beta-lactamase; pfam00144 932677011694 transcriptional repressor IclR; Provisional; Region: PRK11569 932677011695 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 932677011696 Bacterial transcriptional regulator; Region: IclR; pfam01614 932677011697 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 932677011698 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 932677011699 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 932677011700 substrate binding pocket [chemical binding]; other site 932677011701 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 932677011702 B12 binding site [chemical binding]; other site 932677011703 cobalt ligand [ion binding]; other site 932677011704 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 932677011705 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 932677011706 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 932677011707 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 932677011708 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 932677011709 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 932677011710 active site 932677011711 dimer interface [polypeptide binding]; other site 932677011712 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 932677011713 dimer interface [polypeptide binding]; other site 932677011714 active site 932677011715 aspartate kinase III; Validated; Region: PRK09084 932677011716 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 932677011717 nucleotide binding site [chemical binding]; other site 932677011718 substrate binding site [chemical binding]; other site 932677011719 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 932677011720 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 932677011721 dimer interface [polypeptide binding]; other site 932677011722 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 932677011723 Sodium Bile acid symporter family; Region: SBF; pfam01758 932677011724 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 932677011725 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 932677011726 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 932677011727 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 932677011728 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 932677011729 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 932677011730 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 932677011731 UbiA prenyltransferase family; Region: UbiA; pfam01040 932677011732 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 932677011733 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 932677011734 putative acyl-acceptor binding pocket; other site 932677011735 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 932677011736 LexA repressor; Validated; Region: PRK00215 932677011737 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 932677011738 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 932677011739 Catalytic site [active] 932677011740 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 932677011741 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 932677011742 hypothetical protein; Provisional; Region: PRK10428 932677011743 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 932677011744 metal binding site 2 [ion binding]; metal-binding site 932677011745 putative DNA binding helix; other site 932677011746 metal binding site 1 [ion binding]; metal-binding site 932677011747 dimer interface [polypeptide binding]; other site 932677011748 structural Zn2+ binding site [ion binding]; other site 932677011749 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 932677011750 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 932677011751 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 932677011752 FMN binding site [chemical binding]; other site 932677011753 active site 932677011754 catalytic residues [active] 932677011755 substrate binding site [chemical binding]; other site 932677011756 phage shock protein G; Reviewed; Region: pspG; PRK09459 932677011757 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 932677011758 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 932677011759 NADP binding site [chemical binding]; other site 932677011760 dimer interface [polypeptide binding]; other site 932677011761 replicative DNA helicase; Provisional; Region: PRK08006 932677011762 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 932677011763 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 932677011764 Walker A motif; other site 932677011765 ATP binding site [chemical binding]; other site 932677011766 Walker B motif; other site 932677011767 DNA binding loops [nucleotide binding] 932677011768 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 932677011769 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 932677011770 putative DNA binding site [nucleotide binding]; other site 932677011771 putative Zn2+ binding site [ion binding]; other site 932677011772 AsnC family; Region: AsnC_trans_reg; pfam01037 932677011773 Uncharacterized conserved protein [Function unknown]; Region: COG1284 932677011774 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 932677011775 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 932677011776 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 932677011777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677011778 homodimer interface [polypeptide binding]; other site 932677011779 catalytic residue [active] 932677011780 Uncharacterized conserved protein [Function unknown]; Region: COG0432 932677011781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 932677011782 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 932677011783 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 932677011784 putative NAD(P) binding site [chemical binding]; other site 932677011785 putative substrate binding site [chemical binding]; other site 932677011786 catalytic Zn binding site [ion binding]; other site 932677011787 structural Zn binding site [ion binding]; other site 932677011788 dimer interface [polypeptide binding]; other site 932677011789 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 932677011790 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 932677011791 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 932677011792 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 932677011793 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 932677011794 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 932677011795 dimer interface [polypeptide binding]; other site 932677011796 ssDNA binding site [nucleotide binding]; other site 932677011797 tetramer (dimer of dimers) interface [polypeptide binding]; other site 932677011798 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 932677011799 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 932677011800 catalytic triad [active] 932677011801 conserved cis-peptide bond; other site 932677011802 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 932677011803 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 932677011804 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677011805 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 932677011806 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 932677011807 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 932677011808 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 932677011809 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677011810 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 932677011811 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 932677011812 DNA binding residues [nucleotide binding] 932677011813 dimer interface [polypeptide binding]; other site 932677011814 [2Fe-2S] cluster binding site [ion binding]; other site 932677011815 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 932677011816 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 932677011817 putative C-terminal domain interface [polypeptide binding]; other site 932677011818 putative GSH binding site (G-site) [chemical binding]; other site 932677011819 putative dimer interface [polypeptide binding]; other site 932677011820 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 932677011821 putative N-terminal domain interface [polypeptide binding]; other site 932677011822 putative dimer interface [polypeptide binding]; other site 932677011823 putative substrate binding pocket (H-site) [chemical binding]; other site 932677011824 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 932677011825 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 932677011826 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677011827 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677011828 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 932677011829 putative dimerization interface [polypeptide binding]; other site 932677011830 LrgA family; Region: LrgA; pfam03788 932677011831 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 932677011832 YfaZ precursor; Region: YfaZ; pfam07437 932677011833 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 932677011834 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 932677011835 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 932677011836 Na binding site [ion binding]; other site 932677011837 Predicted membrane protein [Function unknown]; Region: COG3162 932677011838 acetyl-CoA synthetase; Provisional; Region: PRK00174 932677011839 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 932677011840 active site 932677011841 CoA binding site [chemical binding]; other site 932677011842 acyl-activating enzyme (AAE) consensus motif; other site 932677011843 AMP binding site [chemical binding]; other site 932677011844 acetate binding site [chemical binding]; other site 932677011845 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 932677011846 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 932677011847 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 932677011848 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 932677011849 putative active site [active] 932677011850 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 932677011851 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 932677011852 active site turn [active] 932677011853 phosphorylation site [posttranslational modification] 932677011854 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 932677011855 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932677011856 PAS domain; Region: PAS_9; pfam13426 932677011857 putative active site [active] 932677011858 heme pocket [chemical binding]; other site 932677011859 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 932677011860 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677011861 dimer interface [polypeptide binding]; other site 932677011862 putative CheW interface [polypeptide binding]; other site 932677011863 Cupin; Region: Cupin_6; pfam12852 932677011864 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677011865 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 932677011866 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677011867 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 932677011868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677011869 putative substrate translocation pore; other site 932677011870 microcin B17 transporter; Reviewed; Region: PRK11098 932677011871 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 932677011872 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 932677011873 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932677011874 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 932677011875 Cytochrome c; Region: Cytochrom_C; pfam00034 932677011876 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 932677011877 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 932677011878 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 932677011879 benzoate transport; Region: 2A0115; TIGR00895 932677011880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677011881 putative substrate translocation pore; other site 932677011882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677011883 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 932677011884 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932677011885 dimerization interface [polypeptide binding]; other site 932677011886 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677011887 dimer interface [polypeptide binding]; other site 932677011888 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 932677011889 putative CheW interface [polypeptide binding]; other site 932677011890 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 932677011891 dimer interface [polypeptide binding]; other site 932677011892 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932677011893 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 932677011894 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 932677011895 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 932677011896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932677011897 dimer interface [polypeptide binding]; other site 932677011898 phosphorylation site [posttranslational modification] 932677011899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677011900 ATP binding site [chemical binding]; other site 932677011901 Mg2+ binding site [ion binding]; other site 932677011902 G-X-G motif; other site 932677011903 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 932677011904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677011905 active site 932677011906 phosphorylation site [posttranslational modification] 932677011907 intermolecular recognition site; other site 932677011908 dimerization interface [polypeptide binding]; other site 932677011909 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932677011910 DNA binding site [nucleotide binding] 932677011911 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 932677011912 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677011913 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677011914 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677011915 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677011916 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 932677011917 putative effector binding pocket; other site 932677011918 dimerization interface [polypeptide binding]; other site 932677011919 drug efflux system protein MdtG; Provisional; Region: PRK09874 932677011920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677011921 putative substrate translocation pore; other site 932677011922 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 932677011923 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 932677011924 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 932677011925 Trp docking motif [polypeptide binding]; other site 932677011926 putative active site [active] 932677011927 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 932677011928 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932677011929 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 932677011930 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 932677011931 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932677011932 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932677011933 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 932677011934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677011935 Walker A/P-loop; other site 932677011936 ATP binding site [chemical binding]; other site 932677011937 Q-loop/lid; other site 932677011938 ABC transporter signature motif; other site 932677011939 Walker B; other site 932677011940 D-loop; other site 932677011941 H-loop/switch region; other site 932677011942 TOBE domain; Region: TOBE_2; pfam08402 932677011943 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 932677011944 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 932677011945 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 932677011946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677011947 dimer interface [polypeptide binding]; other site 932677011948 conserved gate region; other site 932677011949 putative PBP binding loops; other site 932677011950 ABC-ATPase subunit interface; other site 932677011951 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 932677011952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677011953 dimer interface [polypeptide binding]; other site 932677011954 conserved gate region; other site 932677011955 putative PBP binding loops; other site 932677011956 ABC-ATPase subunit interface; other site 932677011957 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 932677011958 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 932677011959 tartrate dehydrogenase; Region: TTC; TIGR02089 932677011960 LysR family transcriptional regulator; Provisional; Region: PRK14997 932677011961 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 932677011962 dimerization interface [polypeptide binding]; other site 932677011963 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 932677011964 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677011965 dimer interface [polypeptide binding]; other site 932677011966 putative CheW interface [polypeptide binding]; other site 932677011967 putative S-transferase; Provisional; Region: PRK11752 932677011968 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 932677011969 C-terminal domain interface [polypeptide binding]; other site 932677011970 GSH binding site (G-site) [chemical binding]; other site 932677011971 dimer interface [polypeptide binding]; other site 932677011972 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 932677011973 N-terminal domain interface [polypeptide binding]; other site 932677011974 dimer interface [polypeptide binding]; other site 932677011975 substrate binding pocket (H-site) [chemical binding]; other site 932677011976 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 932677011977 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 932677011978 putative substrate binding site [chemical binding]; other site 932677011979 putative ATP binding site [chemical binding]; other site 932677011980 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 932677011981 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 932677011982 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 932677011983 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 932677011984 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 932677011985 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 932677011986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677011987 putative substrate translocation pore; other site 932677011988 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 932677011989 trimer interface; other site 932677011990 sugar binding site [chemical binding]; other site 932677011991 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 932677011992 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 932677011993 active site turn [active] 932677011994 phosphorylation site [posttranslational modification] 932677011995 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 932677011996 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 932677011997 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 932677011998 substrate binding [chemical binding]; other site 932677011999 active site 932677012000 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 932677012001 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 932677012002 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 932677012003 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 932677012004 dimerization interface [polypeptide binding]; other site 932677012005 ligand binding site [chemical binding]; other site 932677012006 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 932677012007 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 932677012008 dimerization domain [polypeptide binding]; other site 932677012009 dimer interface [polypeptide binding]; other site 932677012010 catalytic residues [active] 932677012011 Putative phosphatase (DUF442); Region: DUF442; cl17385 932677012012 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 932677012013 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 932677012014 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 932677012015 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 932677012016 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677012017 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677012018 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 932677012019 dimerization interface [polypeptide binding]; other site 932677012020 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 932677012021 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 932677012022 FAD binding pocket [chemical binding]; other site 932677012023 FAD binding motif [chemical binding]; other site 932677012024 phosphate binding motif [ion binding]; other site 932677012025 NAD binding pocket [chemical binding]; other site 932677012026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677012027 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932677012028 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 932677012029 IucA / IucC family; Region: IucA_IucC; pfam04183 932677012030 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 932677012031 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 932677012032 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 932677012033 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 932677012034 IucA / IucC family; Region: IucA_IucC; pfam04183 932677012035 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 932677012036 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 932677012037 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932677012038 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 932677012039 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 932677012040 N-terminal plug; other site 932677012041 ligand-binding site [chemical binding]; other site 932677012042 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 932677012043 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677012044 dimer interface [polypeptide binding]; other site 932677012045 putative CheW interface [polypeptide binding]; other site 932677012046 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 932677012047 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 932677012048 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 932677012049 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 932677012050 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 932677012051 intersubunit interface [polypeptide binding]; other site 932677012052 active site 932677012053 Zn2+ binding site [ion binding]; other site 932677012054 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 932677012055 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 932677012056 AP (apurinic/apyrimidinic) site pocket; other site 932677012057 DNA interaction; other site 932677012058 Metal-binding active site; metal-binding site 932677012059 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 932677012060 active site 932677012061 magnesium binding site [ion binding]; other site 932677012062 dimer interface [polypeptide binding]; other site 932677012063 potential protein location (hypothetical protein) that overlaps protein (probable hexulose-6-phosphate synthase SgbH) 932677012064 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 932677012065 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 932677012066 putative N- and C-terminal domain interface [polypeptide binding]; other site 932677012067 putative active site [active] 932677012068 MgATP binding site [chemical binding]; other site 932677012069 catalytic site [active] 932677012070 metal binding site [ion binding]; metal-binding site 932677012071 putative xylulose binding site [chemical binding]; other site 932677012072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677012073 D-galactonate transporter; Region: 2A0114; TIGR00893 932677012074 putative substrate translocation pore; other site 932677012075 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 932677012076 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 932677012077 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 932677012078 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315 932677012079 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 932677012080 putative ligand binding site [chemical binding]; other site 932677012081 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 932677012082 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932677012083 TM-ABC transporter signature motif; other site 932677012084 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 932677012085 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 932677012086 Walker A/P-loop; other site 932677012087 ATP binding site [chemical binding]; other site 932677012088 Q-loop/lid; other site 932677012089 ABC transporter signature motif; other site 932677012090 Walker B; other site 932677012091 D-loop; other site 932677012092 H-loop/switch region; other site 932677012093 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 932677012094 Transcriptional regulator [Transcription]; Region: IclR; COG1414 932677012095 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 932677012096 Bacterial transcriptional regulator; Region: IclR; pfam01614 932677012097 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 932677012098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677012099 Coenzyme A binding pocket [chemical binding]; other site 932677012100 AAA domain; Region: AAA_17; pfam13207 932677012101 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 932677012102 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 932677012103 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 932677012104 active site 932677012105 catalytic tetrad [active] 932677012106 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 932677012107 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 932677012108 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 932677012109 conserved cys residue [active] 932677012110 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677012111 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 932677012112 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 932677012113 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 932677012114 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 932677012115 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 932677012116 dimer interface [polypeptide binding]; other site 932677012117 ligand binding site [chemical binding]; other site 932677012118 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932677012119 dimerization interface [polypeptide binding]; other site 932677012120 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677012121 dimer interface [polypeptide binding]; other site 932677012122 putative CheW interface [polypeptide binding]; other site 932677012123 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 932677012124 DNA-binding site [nucleotide binding]; DNA binding site 932677012125 RNA-binding motif; other site 932677012126 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 932677012127 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 932677012128 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 932677012129 G1 box; other site 932677012130 GTP/Mg2+ binding site [chemical binding]; other site 932677012131 Switch I region; other site 932677012132 G2 box; other site 932677012133 G3 box; other site 932677012134 Switch II region; other site 932677012135 G4 box; other site 932677012136 G5 box; other site 932677012137 Nucleoside recognition; Region: Gate; pfam07670 932677012138 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 932677012139 Nucleoside recognition; Region: Gate; pfam07670 932677012140 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 932677012141 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 932677012142 active site 932677012143 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 932677012144 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 932677012145 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 932677012146 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 932677012147 active site 932677012148 putative transcriptional regulator; Provisional; Region: PRK11640 932677012149 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 932677012150 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 932677012151 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 932677012152 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 932677012153 DsbD alpha interface [polypeptide binding]; other site 932677012154 catalytic residues [active] 932677012155 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 932677012156 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 932677012157 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 932677012158 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 932677012159 tetramer interface [polypeptide binding]; other site 932677012160 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 932677012161 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 932677012162 oligomerisation interface [polypeptide binding]; other site 932677012163 mobile loop; other site 932677012164 roof hairpin; other site 932677012165 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 932677012166 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 932677012167 ring oligomerisation interface [polypeptide binding]; other site 932677012168 ATP/Mg binding site [chemical binding]; other site 932677012169 stacking interactions; other site 932677012170 hinge regions; other site 932677012171 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 932677012172 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 932677012173 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 932677012174 FeS/SAM binding site; other site 932677012175 elongation factor P; Validated; Region: PRK00529 932677012176 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 932677012177 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 932677012178 RNA binding site [nucleotide binding]; other site 932677012179 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 932677012180 RNA binding site [nucleotide binding]; other site 932677012181 Entericidin EcnA/B family; Region: Entericidin; pfam08085 932677012182 Predicted small secreted protein [Function unknown]; Region: COG5510 932677012183 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 932677012184 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 932677012185 poxB regulator PoxA; Provisional; Region: PRK09350 932677012186 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 932677012187 motif 1; other site 932677012188 dimer interface [polypeptide binding]; other site 932677012189 active site 932677012190 motif 2; other site 932677012191 motif 3; other site 932677012192 serine endoprotease; Provisional; Region: PRK10898 932677012193 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 932677012194 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 932677012195 protein binding site [polypeptide binding]; other site 932677012196 serine endoprotease; Provisional; Region: PRK10139 932677012197 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 932677012198 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 932677012199 protein binding site [polypeptide binding]; other site 932677012200 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 932677012201 protein binding site [polypeptide binding]; other site 932677012202 hypothetical protein; Provisional; Region: PRK11677 932677012203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 932677012204 Predicted ATPase [General function prediction only]; Region: COG1485 932677012205 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 932677012206 23S rRNA interface [nucleotide binding]; other site 932677012207 L3 interface [polypeptide binding]; other site 932677012208 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 932677012209 stringent starvation protein A; Provisional; Region: sspA; PRK09481 932677012210 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 932677012211 C-terminal domain interface [polypeptide binding]; other site 932677012212 putative GSH binding site (G-site) [chemical binding]; other site 932677012213 dimer interface [polypeptide binding]; other site 932677012214 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 932677012215 dimer interface [polypeptide binding]; other site 932677012216 N-terminal domain interface [polypeptide binding]; other site 932677012217 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 932677012218 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 932677012219 Flavodoxin; Region: Flavodoxin_1; pfam00258 932677012220 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 932677012221 FAD binding pocket [chemical binding]; other site 932677012222 FAD binding motif [chemical binding]; other site 932677012223 catalytic residues [active] 932677012224 NAD binding pocket [chemical binding]; other site 932677012225 phosphate binding motif [ion binding]; other site 932677012226 beta-alpha-beta structure motif; other site 932677012227 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 932677012228 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 932677012229 active site 932677012230 dimer interface [polypeptide binding]; other site 932677012231 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 932677012232 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 932677012233 active site 932677012234 FMN binding site [chemical binding]; other site 932677012235 substrate binding site [chemical binding]; other site 932677012236 3Fe-4S cluster binding site [ion binding]; other site 932677012237 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 932677012238 domain_subunit interface; other site 932677012239 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 932677012240 Remorin, C-terminal region; Region: Remorin_C; pfam03763 932677012241 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932677012242 putative active site [active] 932677012243 heme pocket [chemical binding]; other site 932677012244 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932677012245 dimer interface [polypeptide binding]; other site 932677012246 phosphorylation site [posttranslational modification] 932677012247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677012248 ATP binding site [chemical binding]; other site 932677012249 Mg2+ binding site [ion binding]; other site 932677012250 G-X-G motif; other site 932677012251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677012252 active site 932677012253 phosphorylation site [posttranslational modification] 932677012254 intermolecular recognition site; other site 932677012255 dimerization interface [polypeptide binding]; other site 932677012256 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 932677012257 putative binding surface; other site 932677012258 active site 932677012259 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 932677012260 Transglycosylase; Region: Transgly; cl17702 932677012261 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 932677012262 dimerization domain swap beta strand [polypeptide binding]; other site 932677012263 regulatory protein interface [polypeptide binding]; other site 932677012264 active site 932677012265 regulatory phosphorylation site [posttranslational modification]; other site 932677012266 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 932677012267 AAA domain; Region: AAA_18; pfam13238 932677012268 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 932677012269 active site 932677012270 phosphorylation site [posttranslational modification] 932677012271 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 932677012272 30S subunit binding site; other site 932677012273 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 932677012274 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 932677012275 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 932677012276 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 932677012277 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 932677012278 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 932677012279 Walker A/P-loop; other site 932677012280 ATP binding site [chemical binding]; other site 932677012281 Q-loop/lid; other site 932677012282 ABC transporter signature motif; other site 932677012283 Walker B; other site 932677012284 D-loop; other site 932677012285 H-loop/switch region; other site 932677012286 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 932677012287 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 932677012288 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 932677012289 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 932677012290 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 932677012291 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 932677012292 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 932677012293 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 932677012294 putative active site [active] 932677012295 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 932677012296 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 932677012297 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 932677012298 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 932677012299 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 932677012300 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 932677012301 Walker A/P-loop; other site 932677012302 ATP binding site [chemical binding]; other site 932677012303 Q-loop/lid; other site 932677012304 ABC transporter signature motif; other site 932677012305 Walker B; other site 932677012306 D-loop; other site 932677012307 H-loop/switch region; other site 932677012308 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 932677012309 conserved hypothetical integral membrane protein; Region: TIGR00056 932677012310 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 932677012311 mce related protein; Region: MCE; pfam02470 932677012312 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 932677012313 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 932677012314 anti sigma factor interaction site; other site 932677012315 regulatory phosphorylation site [posttranslational modification]; other site 932677012316 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 932677012317 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 932677012318 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 932677012319 hinge; other site 932677012320 active site 932677012321 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 932677012322 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 932677012323 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 932677012324 substrate binding pocket [chemical binding]; other site 932677012325 chain length determination region; other site 932677012326 substrate-Mg2+ binding site; other site 932677012327 catalytic residues [active] 932677012328 aspartate-rich region 1; other site 932677012329 active site lid residues [active] 932677012330 aspartate-rich region 2; other site 932677012331 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 932677012332 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 932677012333 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 932677012334 GTPase CgtA; Reviewed; Region: obgE; PRK12298 932677012335 GTP1/OBG; Region: GTP1_OBG; pfam01018 932677012336 Obg GTPase; Region: Obg; cd01898 932677012337 G1 box; other site 932677012338 GTP/Mg2+ binding site [chemical binding]; other site 932677012339 Switch I region; other site 932677012340 G2 box; other site 932677012341 G3 box; other site 932677012342 Switch II region; other site 932677012343 G4 box; other site 932677012344 G5 box; other site 932677012345 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 932677012346 CoenzymeA binding site [chemical binding]; other site 932677012347 subunit interaction site [polypeptide binding]; other site 932677012348 PHB binding site; other site 932677012349 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 932677012350 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 932677012351 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 932677012352 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 932677012353 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 932677012354 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 932677012355 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 932677012356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677012357 S-adenosylmethionine binding site [chemical binding]; other site 932677012358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677012359 Walker B motif; other site 932677012360 arginine finger; other site 932677012361 Peptidase family M41; Region: Peptidase_M41; pfam01434 932677012362 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 932677012363 dihydropteroate synthase; Region: DHPS; TIGR01496 932677012364 substrate binding pocket [chemical binding]; other site 932677012365 dimer interface [polypeptide binding]; other site 932677012366 inhibitor binding site; inhibition site 932677012367 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 932677012368 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 932677012369 active site 932677012370 substrate binding site [chemical binding]; other site 932677012371 metal binding site [ion binding]; metal-binding site 932677012372 Preprotein translocase SecG subunit; Region: SecG; pfam03840 932677012373 ribosome maturation protein RimP; Reviewed; Region: PRK00092 932677012374 Sm and related proteins; Region: Sm_like; cl00259 932677012375 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 932677012376 putative oligomer interface [polypeptide binding]; other site 932677012377 putative RNA binding site [nucleotide binding]; other site 932677012378 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 932677012379 NusA N-terminal domain; Region: NusA_N; pfam08529 932677012380 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 932677012381 RNA binding site [nucleotide binding]; other site 932677012382 homodimer interface [polypeptide binding]; other site 932677012383 NusA-like KH domain; Region: KH_5; pfam13184 932677012384 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 932677012385 G-X-X-G motif; other site 932677012386 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 932677012387 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 932677012388 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 932677012389 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 932677012390 translation initiation factor IF-2; Region: IF-2; TIGR00487 932677012391 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 932677012392 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 932677012393 G1 box; other site 932677012394 putative GEF interaction site [polypeptide binding]; other site 932677012395 GTP/Mg2+ binding site [chemical binding]; other site 932677012396 Switch I region; other site 932677012397 G2 box; other site 932677012398 G3 box; other site 932677012399 Switch II region; other site 932677012400 G4 box; other site 932677012401 G5 box; other site 932677012402 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 932677012403 Translation-initiation factor 2; Region: IF-2; pfam11987 932677012404 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 932677012405 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 932677012406 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 932677012407 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 932677012408 RNA binding site [nucleotide binding]; other site 932677012409 active site 932677012410 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 932677012411 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 932677012412 16S/18S rRNA binding site [nucleotide binding]; other site 932677012413 S13e-L30e interaction site [polypeptide binding]; other site 932677012414 25S rRNA binding site [nucleotide binding]; other site 932677012415 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 932677012416 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 932677012417 RNase E interface [polypeptide binding]; other site 932677012418 trimer interface [polypeptide binding]; other site 932677012419 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 932677012420 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 932677012421 RNase E interface [polypeptide binding]; other site 932677012422 trimer interface [polypeptide binding]; other site 932677012423 active site 932677012424 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 932677012425 putative nucleic acid binding region [nucleotide binding]; other site 932677012426 G-X-X-G motif; other site 932677012427 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 932677012428 RNA binding site [nucleotide binding]; other site 932677012429 domain interface; other site 932677012430 potential protein location (hypothetical protein) that overlaps protein (polyribonucleotide nucleotidyltransferase Pnp) 932677012431 lipoprotein NlpI; Provisional; Region: PRK11189 932677012432 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 932677012433 binding surface 932677012434 TPR motif; other site 932677012435 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 932677012436 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 932677012437 ATP binding site [chemical binding]; other site 932677012438 Mg++ binding site [ion binding]; other site 932677012439 motif III; other site 932677012440 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932677012441 nucleotide binding region [chemical binding]; other site 932677012442 ATP-binding site [chemical binding]; other site 932677012443 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 932677012444 putative RNA binding site [nucleotide binding]; other site 932677012445 hypothetical protein; Provisional; Region: PRK10508 932677012446 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 932677012447 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 932677012448 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 932677012449 putative protease; Provisional; Region: PRK15447 932677012450 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 932677012451 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 932677012452 Peptidase family U32; Region: Peptidase_U32; pfam01136 932677012453 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 932677012454 putative acetyltransferase; Provisional; Region: PRK03624 932677012455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677012456 Coenzyme A binding pocket [chemical binding]; other site 932677012457 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 932677012458 GIY-YIG motif/motif A; other site 932677012459 putative active site [active] 932677012460 putative metal binding site [ion binding]; other site 932677012461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897 932677012462 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 932677012463 intracellular protease, PfpI family; Region: PfpI; TIGR01382 932677012464 proposed catalytic triad [active] 932677012465 conserved cys residue [active] 932677012466 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 932677012467 NADH(P)-binding; Region: NAD_binding_10; pfam13460 932677012468 NAD binding site [chemical binding]; other site 932677012469 active site 932677012470 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 932677012471 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 932677012472 FeS/SAM binding site; other site 932677012473 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 932677012474 ATP cone domain; Region: ATP-cone; pfam03477 932677012475 Class III ribonucleotide reductase; Region: RNR_III; cd01675 932677012476 effector binding site; other site 932677012477 active site 932677012478 Zn binding site [ion binding]; other site 932677012479 glycine loop; other site 932677012480 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 932677012481 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 932677012482 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 932677012483 active site 932677012484 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 932677012485 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 932677012486 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932677012487 DNA binding site [nucleotide binding] 932677012488 domain linker motif; other site 932677012489 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 932677012490 dimerization interface (closed form) [polypeptide binding]; other site 932677012491 ligand binding site [chemical binding]; other site 932677012492 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 932677012493 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 932677012494 molybdopterin cofactor binding site [chemical binding]; other site 932677012495 substrate binding site [chemical binding]; other site 932677012496 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 932677012497 molybdopterin cofactor binding site; other site 932677012498 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 932677012499 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 932677012500 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 932677012501 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 932677012502 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 932677012503 HlyD family secretion protein; Region: HlyD_3; pfam13437 932677012504 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 932677012505 Protein export membrane protein; Region: SecD_SecF; cl14618 932677012506 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 932677012507 Protein export membrane protein; Region: SecD_SecF; cl14618 932677012508 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 932677012509 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 932677012510 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 932677012511 putative acyl-acceptor binding pocket; other site 932677012512 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 932677012513 acyl-activating enzyme (AAE) consensus motif; other site 932677012514 putative AMP binding site [chemical binding]; other site 932677012515 lysophospholipid transporter LplT; Provisional; Region: PRK11195 932677012516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677012517 putative substrate translocation pore; other site 932677012518 HAMP domain; Region: HAMP; pfam00672 932677012519 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 932677012520 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677012521 dimer interface [polypeptide binding]; other site 932677012522 putative CheW interface [polypeptide binding]; other site 932677012523 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 932677012524 homotrimer interaction site [polypeptide binding]; other site 932677012525 putative active site [active] 932677012526 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 932677012527 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 932677012528 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 932677012529 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 932677012530 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 932677012531 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 932677012532 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 932677012533 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 932677012534 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 932677012535 RNase E inhibitor protein; Provisional; Region: PRK11191 932677012536 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 932677012537 active site 932677012538 dinuclear metal binding site [ion binding]; other site 932677012539 dimerization interface [polypeptide binding]; other site 932677012540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677012541 Coenzyme A binding pocket [chemical binding]; other site 932677012542 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 932677012543 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 932677012544 HIGH motif; other site 932677012545 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 932677012546 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 932677012547 active site 932677012548 KMSKS motif; other site 932677012549 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 932677012550 tRNA binding surface [nucleotide binding]; other site 932677012551 anticodon binding site; other site 932677012552 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 932677012553 DNA polymerase III subunit chi; Validated; Region: PRK05728 932677012554 multifunctional aminopeptidase A; Provisional; Region: PRK00913 932677012555 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 932677012556 interface (dimer of trimers) [polypeptide binding]; other site 932677012557 Substrate-binding/catalytic site; other site 932677012558 Zn-binding sites [ion binding]; other site 932677012559 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 932677012560 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 932677012561 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 932677012562 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 932677012563 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 932677012564 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 932677012565 metal binding site [ion binding]; metal-binding site 932677012566 dimer interface [polypeptide binding]; other site 932677012567 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 932677012568 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 932677012569 active site 932677012570 substrate binding pocket [chemical binding]; other site 932677012571 homodimer interaction site [polypeptide binding]; other site 932677012572 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932677012573 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 932677012574 TM-ABC transporter signature motif; other site 932677012575 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 932677012576 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 932677012577 Walker A/P-loop; other site 932677012578 ATP binding site [chemical binding]; other site 932677012579 Q-loop/lid; other site 932677012580 ABC transporter signature motif; other site 932677012581 Walker B; other site 932677012582 D-loop; other site 932677012583 H-loop/switch region; other site 932677012584 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932677012585 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932677012586 DNA binding site [nucleotide binding] 932677012587 domain linker motif; other site 932677012588 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_11; cd06293 932677012589 putative dimerization interface [polypeptide binding]; other site 932677012590 putative ligand binding site [chemical binding]; other site 932677012591 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 932677012592 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 932677012593 ligand binding site [chemical binding]; other site 932677012594 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 932677012595 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 932677012596 substrate binding site [chemical binding]; other site 932677012597 dimer interface [polypeptide binding]; other site 932677012598 ATP binding site [chemical binding]; other site 932677012599 BtpA family; Region: BtpA; cl00440 932677012600 Predicted membrane protein [Function unknown]; Region: COG2733 932677012601 HipA N-terminal domain; Region: Couple_hipA; cl11853 932677012602 HipA-like N-terminal domain; Region: HipA_N; pfam07805 932677012603 HipA-like C-terminal domain; Region: HipA_C; pfam07804 932677012604 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 932677012605 Zonular occludens toxin (Zot); Region: Zot; cl17485 932677012606 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 932677012607 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 932677012608 inner membrane protein; Provisional; Region: PRK10995 932677012609 potential protein location (hypothetical protein) that overlaps protein (multiple antibiotic resistance protein MarC) 932677012610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932677012611 hypothetical protein; Provisional; Region: PRK11667 932677012612 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 932677012613 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 932677012614 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 932677012615 ATP binding site [chemical binding]; other site 932677012616 putative Mg++ binding site [ion binding]; other site 932677012617 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 932677012618 nucleotide binding region [chemical binding]; other site 932677012619 ATP-binding site [chemical binding]; other site 932677012620 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 932677012621 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 932677012622 ligand binding site [chemical binding]; other site 932677012623 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 932677012624 HsdM N-terminal domain; Region: HsdM_N; pfam12161 932677012625 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 932677012626 Methyltransferase domain; Region: Methyltransf_26; pfam13659 932677012627 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 932677012628 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 932677012629 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 932677012630 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 932677012631 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 932677012632 DEAD-like helicases superfamily; Region: DEXDc; smart00487 932677012633 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 932677012634 ATP binding site [chemical binding]; other site 932677012635 putative Mg++ binding site [ion binding]; other site 932677012636 Phosphotransferase enzyme family; Region: APH; pfam01636 932677012637 active site 932677012638 ATP binding site [chemical binding]; other site 932677012639 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 932677012640 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 932677012641 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 932677012642 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 932677012643 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 932677012644 catalytic residue [active] 932677012645 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 932677012646 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 932677012647 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 932677012648 active site 932677012649 AMP binding site [chemical binding]; other site 932677012650 acyl-activating enzyme (AAE) consensus motif; other site 932677012651 CoA binding site [chemical binding]; other site 932677012652 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677012653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677012654 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 932677012655 dimerization interface [polypeptide binding]; other site 932677012656 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 932677012657 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 932677012658 active site 932677012659 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 932677012660 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677012661 dimer interface [polypeptide binding]; other site 932677012662 putative CheW interface [polypeptide binding]; other site 932677012663 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 932677012664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677012665 D-galactonate transporter; Region: 2A0114; TIGR00893 932677012666 putative substrate translocation pore; other site 932677012667 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 932677012668 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 932677012669 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 932677012670 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 932677012671 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 932677012672 substrate binding site [chemical binding]; other site 932677012673 dimer interface [polypeptide binding]; other site 932677012674 ATP binding site [chemical binding]; other site 932677012675 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 932677012676 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 932677012677 inhibitor site; inhibition site 932677012678 active site 932677012679 dimer interface [polypeptide binding]; other site 932677012680 catalytic residue [active] 932677012681 Domain of unknown function (DUF386); Region: DUF386; cl01047 932677012682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677012683 D-galactonate transporter; Region: 2A0114; TIGR00893 932677012684 putative substrate translocation pore; other site 932677012685 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 932677012686 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 932677012687 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 932677012688 putative acyl-acceptor binding pocket; other site 932677012689 acyl carrier protein; Provisional; Region: PRK05350 932677012690 Predicted membrane protein [Function unknown]; Region: COG4648 932677012691 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 932677012692 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 932677012693 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 932677012694 acyl-activating enzyme (AAE) consensus motif; other site 932677012695 acyl-activating enzyme (AAE) consensus motif; other site 932677012696 AMP binding site [chemical binding]; other site 932677012697 active site 932677012698 CoA binding site [chemical binding]; other site 932677012699 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 932677012700 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 932677012701 Ligand binding site; other site 932677012702 Putative Catalytic site; other site 932677012703 DXD motif; other site 932677012704 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 932677012705 putative acyl-acceptor binding pocket; other site 932677012706 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 932677012707 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 932677012708 Predicted exporter [General function prediction only]; Region: COG4258 932677012709 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 932677012710 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 932677012711 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 932677012712 dimer interface [polypeptide binding]; other site 932677012713 active site 932677012714 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 932677012715 putative active site 1 [active] 932677012716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 932677012717 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 932677012718 NAD(P) binding site [chemical binding]; other site 932677012719 active site 932677012720 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 932677012721 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 932677012722 dimer interface [polypeptide binding]; other site 932677012723 active site 932677012724 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 932677012725 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 932677012726 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 932677012727 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 932677012728 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 932677012729 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 932677012730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677012731 Coenzyme A binding pocket [chemical binding]; other site 932677012732 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 932677012733 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 932677012734 glycerate dehydrogenase; Provisional; Region: PRK06487 932677012735 putative ligand binding site [chemical binding]; other site 932677012736 putative NAD binding site [chemical binding]; other site 932677012737 catalytic site [active] 932677012738 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 932677012739 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 932677012740 putative active site; other site 932677012741 catalytic residue [active] 932677012742 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 932677012743 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 932677012744 putative NAD(P) binding site [chemical binding]; other site 932677012745 catalytic Zn binding site [ion binding]; other site 932677012746 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 932677012747 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 932677012748 nucleotide binding site [chemical binding]; other site 932677012749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677012750 D-galactonate transporter; Region: 2A0114; TIGR00893 932677012751 putative substrate translocation pore; other site 932677012752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677012753 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 932677012754 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 932677012755 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677012756 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 932677012757 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 932677012758 active site 932677012759 substrate binding site [chemical binding]; other site 932677012760 ATP binding site [chemical binding]; other site 932677012761 ethanolamine permease; Region: 2A0305; TIGR00908 932677012762 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 932677012763 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 932677012764 inhibitor-cofactor binding pocket; inhibition site 932677012765 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677012766 catalytic residue [active] 932677012767 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 932677012768 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 932677012769 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 932677012770 NADP binding site [chemical binding]; other site 932677012771 homodimer interface [polypeptide binding]; other site 932677012772 active site 932677012773 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 932677012774 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 932677012775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677012776 dimer interface [polypeptide binding]; other site 932677012777 conserved gate region; other site 932677012778 putative PBP binding loops; other site 932677012779 ABC-ATPase subunit interface; other site 932677012780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677012781 dimer interface [polypeptide binding]; other site 932677012782 conserved gate region; other site 932677012783 putative PBP binding loops; other site 932677012784 ABC-ATPase subunit interface; other site 932677012785 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 932677012786 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 932677012787 Walker A/P-loop; other site 932677012788 ATP binding site [chemical binding]; other site 932677012789 Q-loop/lid; other site 932677012790 ABC transporter signature motif; other site 932677012791 Walker B; other site 932677012792 D-loop; other site 932677012793 H-loop/switch region; other site 932677012794 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 932677012795 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 932677012796 metal binding site [ion binding]; metal-binding site 932677012797 substrate binding pocket [chemical binding]; other site 932677012798 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 932677012799 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 932677012800 NADP binding site [chemical binding]; other site 932677012801 homodimer interface [polypeptide binding]; other site 932677012802 active site 932677012803 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 932677012804 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 932677012805 putative NAD(P) binding site [chemical binding]; other site 932677012806 catalytic Zn binding site [ion binding]; other site 932677012807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677012808 metabolite-proton symporter; Region: 2A0106; TIGR00883 932677012809 putative substrate translocation pore; other site 932677012810 Transcriptional regulators [Transcription]; Region: FadR; COG2186 932677012811 FCD domain; Region: FCD; pfam07729 932677012812 hypothetical protein; Provisional; Region: PRK10396 932677012813 yecA family protein; Region: ygfB_yecA; TIGR02292 932677012814 SEC-C motif; Region: SEC-C; pfam02810 932677012815 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 932677012816 Beta-lactamase; Region: Beta-lactamase; pfam00144 932677012817 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 932677012818 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 932677012819 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 932677012820 phosphoglycerol transferase I; Provisional; Region: PRK03776 932677012821 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 932677012822 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 932677012823 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 932677012824 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 932677012825 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 932677012826 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 932677012827 catalytic core [active] 932677012828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677012829 metabolite-proton symporter; Region: 2A0106; TIGR00883 932677012830 putative substrate translocation pore; other site 932677012831 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932677012832 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932677012833 DNA binding site [nucleotide binding] 932677012834 domain linker motif; other site 932677012835 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 932677012836 dimerization interface [polypeptide binding]; other site 932677012837 ligand binding site [chemical binding]; other site 932677012838 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 932677012839 active site 932677012840 putative sialic acid transporter; Region: 2A0112; TIGR00891 932677012841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677012842 putative substrate translocation pore; other site 932677012843 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 932677012844 putative deacylase active site [active] 932677012845 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932677012846 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932677012847 metal binding site [ion binding]; metal-binding site 932677012848 active site 932677012849 I-site; other site 932677012850 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 932677012851 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 932677012852 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 932677012853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 932677012854 S-adenosylmethionine binding site [chemical binding]; other site 932677012855 DNA polymerase III subunit psi; Validated; Region: PRK06856 932677012856 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 932677012857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677012858 Coenzyme A binding pocket [chemical binding]; other site 932677012859 dUMP phosphatase; Provisional; Region: PRK09449 932677012860 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677012861 motif II; other site 932677012862 hypothetical protein; Provisional; Region: PRK11246 932677012863 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 932677012864 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677012865 motif II; other site 932677012866 DNA repair protein RadA; Provisional; Region: PRK11823 932677012867 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 932677012868 ATP binding site [chemical binding]; other site 932677012869 Walker B motif; other site 932677012870 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 932677012871 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932677012872 non-specific DNA binding site [nucleotide binding]; other site 932677012873 salt bridge; other site 932677012874 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 932677012875 sequence-specific DNA binding site [nucleotide binding]; other site 932677012876 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 932677012877 active site 932677012878 (T/H)XGH motif; other site 932677012879 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 932677012880 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 932677012881 DNA binding site [nucleotide binding] 932677012882 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 932677012883 putative chaperone protein EcpD; Provisional; Region: PRK09926 932677012884 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 932677012885 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 932677012886 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 932677012887 PapC N-terminal domain; Region: PapC_N; pfam13954 932677012888 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 932677012889 PapC C-terminal domain; Region: PapC_C; pfam13953 932677012890 Fimbrial protein; Region: Fimbrial; cl01416 932677012891 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 932677012892 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 932677012893 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 932677012894 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 932677012895 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 932677012896 putative NAD(P) binding site [chemical binding]; other site 932677012897 dimer interface [polypeptide binding]; other site 932677012898 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677012899 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677012900 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 932677012901 putative effector binding pocket; other site 932677012902 dimerization interface [polypeptide binding]; other site 932677012903 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 932677012904 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932677012905 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932677012906 ABC transporter; Region: ABC_tran_2; pfam12848 932677012907 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 932677012908 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 932677012909 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 932677012910 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 932677012911 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 932677012912 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 932677012913 substrate binding site [chemical binding]; other site 932677012914 dimer interface [polypeptide binding]; other site 932677012915 ATP binding site [chemical binding]; other site 932677012916 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 932677012917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677012918 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 932677012919 active site 932677012920 catalytic residues [active] 932677012921 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 932677012922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677012923 catalytic residue [active] 932677012924 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 932677012925 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 932677012926 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 932677012927 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 932677012928 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 932677012929 IucA / IucC family; Region: IucA_IucC; pfam04183 932677012930 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 932677012931 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 932677012932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677012933 putative substrate translocation pore; other site 932677012934 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 932677012935 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 932677012936 N-terminal plug; other site 932677012937 ligand-binding site [chemical binding]; other site 932677012938 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 932677012939 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 932677012940 Walker A/P-loop; other site 932677012941 ATP binding site [chemical binding]; other site 932677012942 Q-loop/lid; other site 932677012943 ABC transporter signature motif; other site 932677012944 Walker B; other site 932677012945 D-loop; other site 932677012946 H-loop/switch region; other site 932677012947 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 932677012948 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 932677012949 Walker A/P-loop; other site 932677012950 ATP binding site [chemical binding]; other site 932677012951 Q-loop/lid; other site 932677012952 ABC transporter signature motif; other site 932677012953 Walker B; other site 932677012954 D-loop; other site 932677012955 H-loop/switch region; other site 932677012956 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 932677012957 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 932677012958 TM-ABC transporter signature motif; other site 932677012959 HEAT repeats; Region: HEAT_2; pfam13646 932677012960 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 932677012961 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 932677012962 TM-ABC transporter signature motif; other site 932677012963 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 932677012964 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 932677012965 putative ligand binding site [chemical binding]; other site 932677012966 Transcriptional regulators [Transcription]; Region: GntR; COG1802 932677012967 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 932677012968 DNA-binding site [nucleotide binding]; DNA binding site 932677012969 FCD domain; Region: FCD; pfam07729 932677012970 urea carboxylase; Region: urea_carbox; TIGR02712 932677012971 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 932677012972 ATP-grasp domain; Region: ATP-grasp_4; cl17255 932677012973 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 932677012974 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 932677012975 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 932677012976 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 932677012977 carboxyltransferase (CT) interaction site; other site 932677012978 biotinylation site [posttranslational modification]; other site 932677012979 lytic murein transglycosylase; Provisional; Region: PRK11619 932677012980 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 932677012981 N-acetyl-D-glucosamine binding site [chemical binding]; other site 932677012982 catalytic residue [active] 932677012983 Trp operon repressor; Provisional; Region: PRK01381 932677012984 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 932677012985 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 932677012986 catalytic core [active] 932677012987 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 932677012988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677012989 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 932677012990 hypothetical protein; Provisional; Region: PRK10756 932677012991 CreA protein; Region: CreA; pfam05981 932677012992 two-component response regulator; Provisional; Region: PRK11173 932677012993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677012994 active site 932677012995 phosphorylation site [posttranslational modification] 932677012996 intermolecular recognition site; other site 932677012997 dimerization interface [polypeptide binding]; other site 932677012998 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932677012999 DNA binding site [nucleotide binding] 932677013000 putative RNA methyltransferase; Provisional; Region: PRK10433 932677013001 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 932677013002 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 932677013003 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 932677013004 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 932677013005 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 932677013006 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 932677013007 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 932677013008 putative active site [active] 932677013009 putative catalytic site [active] 932677013010 putative Zn binding site [ion binding]; other site 932677013011 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 932677013012 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 932677013013 active site 932677013014 substrate binding site [chemical binding]; other site 932677013015 cosubstrate binding site; other site 932677013016 catalytic site [active] 932677013017 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 932677013018 active site 932677013019 hexamer interface [polypeptide binding]; other site 932677013020 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 932677013021 NAD binding site [chemical binding]; other site 932677013022 substrate binding site [chemical binding]; other site 932677013023 active site 932677013024 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 932677013025 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 932677013026 Ligand binding site; other site 932677013027 Putative Catalytic site; other site 932677013028 DXD motif; other site 932677013029 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 932677013030 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 932677013031 inhibitor-cofactor binding pocket; inhibition site 932677013032 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677013033 catalytic residue [active] 932677013034 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 932677013035 dimer interface [polypeptide binding]; other site 932677013036 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932677013037 ligand binding site [chemical binding]; other site 932677013038 MltA-interacting protein MipA; Region: MipA; cl01504 932677013039 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 932677013040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677013041 active site 932677013042 phosphorylation site [posttranslational modification] 932677013043 intermolecular recognition site; other site 932677013044 dimerization interface [polypeptide binding]; other site 932677013045 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 932677013046 DNA binding site [nucleotide binding] 932677013047 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 932677013048 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 932677013049 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 932677013050 dimer interface [polypeptide binding]; other site 932677013051 phosphorylation site [posttranslational modification] 932677013052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677013053 ATP binding site [chemical binding]; other site 932677013054 Mg2+ binding site [ion binding]; other site 932677013055 G-X-G motif; other site 932677013056 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 932677013057 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 932677013058 HlyD family secretion protein; Region: HlyD_3; pfam13437 932677013059 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 932677013060 HAMP domain; Region: HAMP; pfam00672 932677013061 dimerization interface [polypeptide binding]; other site 932677013062 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 932677013063 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677013064 dimer interface [polypeptide binding]; other site 932677013065 putative CheW interface [polypeptide binding]; other site 932677013066 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 932677013067 putative active site pocket [active] 932677013068 dimerization interface [polypeptide binding]; other site 932677013069 putative catalytic residue [active] 932677013070 EamA-like transporter family; Region: EamA; pfam00892 932677013071 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 932677013072 EamA-like transporter family; Region: EamA; pfam00892 932677013073 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 932677013074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 932677013075 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 932677013076 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 932677013077 substrate binding pocket [chemical binding]; other site 932677013078 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 932677013079 D-mannonate oxidoreductase; Provisional; Region: PRK15037 932677013080 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 932677013081 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 932677013082 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 932677013083 aromatic amino acid transport protein; Region: araaP; TIGR00837 932677013084 tyrosine phenol-lyase; Provisional; Region: PRK13237 932677013085 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 932677013086 substrate binding site [chemical binding]; other site 932677013087 tetramer interface [polypeptide binding]; other site 932677013088 catalytic residue [active] 932677013089 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 932677013090 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 932677013091 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 932677013092 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 932677013093 active site 932677013094 NAD binding site [chemical binding]; other site 932677013095 metal binding site [ion binding]; metal-binding site 932677013096 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 932677013097 Na binding site [ion binding]; other site 932677013098 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 932677013099 BNR repeat-like domain; Region: BNR_2; pfam13088 932677013100 Domain of unknown function (DUF386); Region: DUF386; cl01047 932677013101 short chain dehydrogenase; Provisional; Region: PRK07577 932677013102 classical (c) SDRs; Region: SDR_c; cd05233 932677013103 NAD(P) binding site [chemical binding]; other site 932677013104 active site 932677013105 Cupin domain; Region: Cupin_2; cl17218 932677013106 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 932677013107 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 932677013108 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 932677013109 riboflavin synthase subunit beta; Provisional; Region: PRK12419 932677013110 active site 932677013111 homopentamer interface [polypeptide binding]; other site 932677013112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 932677013113 SnoaL-like domain; Region: SnoaL_2; pfam12680 932677013114 acetoin reductase; Validated; Region: PRK08643 932677013115 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 932677013116 NAD binding site [chemical binding]; other site 932677013117 homotetramer interface [polypeptide binding]; other site 932677013118 homodimer interface [polypeptide binding]; other site 932677013119 active site 932677013120 substrate binding site [chemical binding]; other site 932677013121 acetolactate synthase; Reviewed; Region: PRK08617 932677013122 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 932677013123 PYR/PP interface [polypeptide binding]; other site 932677013124 dimer interface [polypeptide binding]; other site 932677013125 TPP binding site [chemical binding]; other site 932677013126 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 932677013127 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 932677013128 TPP-binding site [chemical binding]; other site 932677013129 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 932677013130 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677013131 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677013132 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 932677013133 putative dimerization interface [polypeptide binding]; other site 932677013134 putative substrate binding pocket [chemical binding]; other site 932677013135 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 932677013136 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 932677013137 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 932677013138 NAD(P) binding site [chemical binding]; other site 932677013139 Cache domain; Region: Cache_1; pfam02743 932677013140 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 932677013141 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677013142 dimer interface [polypeptide binding]; other site 932677013143 putative CheW interface [polypeptide binding]; other site 932677013144 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 932677013145 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 932677013146 YebG protein; Region: YebG; pfam07130 932677013147 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 932677013148 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 932677013149 active site 932677013150 dimerization interface [polypeptide binding]; other site 932677013151 potential frameshift: common BLAST hit: gi|378769357|ref|YP_005197831.1| TonB-dependent siderophore receptor 932677013152 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 932677013153 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 932677013154 N-terminal plug; other site 932677013155 ligand-binding site [chemical binding]; other site 932677013156 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 932677013157 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 932677013158 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 932677013159 active site 932677013160 DNA binding site [nucleotide binding] 932677013161 Int/Topo IB signature motif; other site 932677013162 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 932677013163 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 932677013164 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 932677013165 active site 932677013166 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 932677013167 MASE2 domain; Region: MASE2; pfam05230 932677013168 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932677013169 metal binding site [ion binding]; metal-binding site 932677013170 active site 932677013171 I-site; other site 932677013172 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 932677013173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677013174 active site 932677013175 motif I; other site 932677013176 motif II; other site 932677013177 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 932677013178 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 932677013179 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 932677013180 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 932677013181 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 932677013182 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932677013183 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932677013184 DNA binding site [nucleotide binding] 932677013185 domain linker motif; other site 932677013186 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 932677013187 dimerization interface (closed form) [polypeptide binding]; other site 932677013188 ligand binding site [chemical binding]; other site 932677013189 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 932677013190 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 932677013191 active site turn [active] 932677013192 phosphorylation site [posttranslational modification] 932677013193 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 932677013194 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 932677013195 beta-galactosidase; Region: BGL; TIGR03356 932677013196 GAF domain; Region: GAF; pfam01590 932677013197 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 932677013198 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 932677013199 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932677013200 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 932677013201 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 932677013202 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 932677013203 Sensors of blue-light using FAD; Region: BLUF; pfam04940 932677013204 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932677013205 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 932677013206 GAF domain; Region: GAF; pfam01590 932677013207 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932677013208 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932677013209 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 932677013210 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 932677013211 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 932677013212 RNA binding surface [nucleotide binding]; other site 932677013213 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 932677013214 probable active site [active] 932677013215 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 932677013216 active site 932677013217 oxyanion hole [active] 932677013218 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 932677013219 catalytic triad [active] 932677013220 Autotransporter beta-domain; Region: Autotransporter; cl17461 932677013221 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 932677013222 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 932677013223 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 932677013224 putative active site [active] 932677013225 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 932677013226 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 932677013227 N-terminal plug; other site 932677013228 ligand-binding site [chemical binding]; other site 932677013229 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 932677013230 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 932677013231 putative ligand binding residues [chemical binding]; other site 932677013232 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 932677013233 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 932677013234 XdhC Rossmann domain; Region: XdhC_C; pfam13478 932677013235 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 932677013236 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 932677013237 Ligand binding site; other site 932677013238 metal-binding site 932677013239 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 932677013240 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 932677013241 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 932677013242 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 932677013243 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 932677013244 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 932677013245 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 932677013246 catalytic loop [active] 932677013247 iron binding site [ion binding]; other site 932677013248 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 932677013249 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 932677013250 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932677013251 ABC-ATPase subunit interface; other site 932677013252 dimer interface [polypeptide binding]; other site 932677013253 putative PBP binding regions; other site 932677013254 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 932677013255 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 932677013256 ABC-ATPase subunit interface; other site 932677013257 dimer interface [polypeptide binding]; other site 932677013258 putative PBP binding regions; other site 932677013259 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 932677013260 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 932677013261 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 932677013262 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 932677013263 metal binding site [ion binding]; metal-binding site 932677013264 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 932677013265 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 932677013266 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 932677013267 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 932677013268 homotrimer interaction site [polypeptide binding]; other site 932677013269 putative active site [active] 932677013270 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 932677013271 ParB-like nuclease domain; Region: ParBc; pfam02195 932677013272 ParB family; Region: ParB; pfam08775 932677013273 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 932677013274 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 932677013275 P-loop; other site 932677013276 Magnesium ion binding site [ion binding]; other site 932677013277 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 932677013278 Magnesium ion binding site [ion binding]; other site 932677013279 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 932677013280 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 932677013281 NAD(P) binding site [chemical binding]; other site 932677013282 catalytic residues [active] 932677013283 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 932677013284 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 932677013285 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 932677013286 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 932677013287 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 932677013288 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 932677013289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677013290 dimer interface [polypeptide binding]; other site 932677013291 conserved gate region; other site 932677013292 putative PBP binding loops; other site 932677013293 ABC-ATPase subunit interface; other site 932677013294 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 932677013295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677013296 dimer interface [polypeptide binding]; other site 932677013297 conserved gate region; other site 932677013298 putative PBP binding loops; other site 932677013299 ABC-ATPase subunit interface; other site 932677013300 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 932677013301 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932677013302 Walker A/P-loop; other site 932677013303 ATP binding site [chemical binding]; other site 932677013304 Q-loop/lid; other site 932677013305 ABC transporter signature motif; other site 932677013306 Walker B; other site 932677013307 D-loop; other site 932677013308 H-loop/switch region; other site 932677013309 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 932677013310 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932677013311 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 932677013312 Walker A/P-loop; other site 932677013313 ATP binding site [chemical binding]; other site 932677013314 Q-loop/lid; other site 932677013315 ABC transporter signature motif; other site 932677013316 Walker B; other site 932677013317 D-loop; other site 932677013318 H-loop/switch region; other site 932677013319 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 932677013320 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932677013321 non-specific DNA binding site [nucleotide binding]; other site 932677013322 salt bridge; other site 932677013323 sequence-specific DNA binding site [nucleotide binding]; other site 932677013324 Cupin domain; Region: Cupin_2; cl17218 932677013325 AzlC protein; Region: AzlC; cl00570 932677013326 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 932677013327 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 932677013328 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 932677013329 thiS-thiF/thiG interaction site; other site 932677013330 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 932677013331 ThiS interaction site; other site 932677013332 putative active site [active] 932677013333 tetramer interface [polypeptide binding]; other site 932677013334 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 932677013335 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 932677013336 ATP binding site [chemical binding]; other site 932677013337 substrate interface [chemical binding]; other site 932677013338 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 932677013339 active site residue [active] 932677013340 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677013341 Coenzyme A binding pocket [chemical binding]; other site 932677013342 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 932677013343 LysE type translocator; Region: LysE; cl00565 932677013344 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 932677013345 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 932677013346 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 932677013347 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 932677013348 Thioredoxin; Region: Thioredoxin_4; cl17273 932677013349 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 932677013350 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 932677013351 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 932677013352 putative NAD(P) binding site [chemical binding]; other site 932677013353 putative substrate binding site [chemical binding]; other site 932677013354 catalytic Zn binding site [ion binding]; other site 932677013355 structural Zn binding site [ion binding]; other site 932677013356 dimer interface [polypeptide binding]; other site 932677013357 beta-carotene hydroxylase; Region: PLN02601 932677013358 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 932677013359 active site lid residues [active] 932677013360 substrate binding pocket [chemical binding]; other site 932677013361 catalytic residues [active] 932677013362 substrate-Mg2+ binding site; other site 932677013363 aspartate-rich region 1; other site 932677013364 aspartate-rich region 2; other site 932677013365 phytoene desaturase; Region: crtI_fam; TIGR02734 932677013366 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 932677013367 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 932677013368 lycopene cyclase; Region: lycopene_cycl; TIGR01789 932677013369 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 932677013370 glycosyltransferase, MGT family; Region: MGT; TIGR01426 932677013371 active site 932677013372 TDP-binding site; other site 932677013373 acceptor substrate-binding pocket; other site 932677013374 homodimer interface [polypeptide binding]; other site 932677013375 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 932677013376 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 932677013377 substrate binding pocket [chemical binding]; other site 932677013378 chain length determination region; other site 932677013379 substrate-Mg2+ binding site; other site 932677013380 catalytic residues [active] 932677013381 aspartate-rich region 1; other site 932677013382 active site lid residues [active] 932677013383 aspartate-rich region 2; other site 932677013384 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 932677013385 potential frameshift: common BLAST hit: gi|378769587|ref|YP_005198064.1| iron-regulated membrane protein 932677013386 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 932677013387 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 932677013388 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 932677013389 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 932677013390 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 932677013391 putative ligand binding site [chemical binding]; other site 932677013392 putative NAD binding site [chemical binding]; other site 932677013393 glutaminase; Provisional; Region: PRK00971 932677013394 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 932677013395 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 932677013396 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 932677013397 Cl- selectivity filter; other site 932677013398 Cl- binding residues [ion binding]; other site 932677013399 pore gating glutamate residue; other site 932677013400 H+/Cl- coupling transport residue; other site 932677013401 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 932677013402 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 932677013403 Cl- binding residues [ion binding]; other site 932677013404 dimer interface [polypeptide binding]; other site 932677013405 Protein of unknown function (DUF770); Region: DUF770; pfam05591 932677013406 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 932677013407 Protein of unknown function (DUF877); Region: DUF877; pfam05943 932677013408 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 932677013409 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 932677013410 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 932677013411 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 932677013412 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 932677013413 ligand binding site [chemical binding]; other site 932677013414 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 932677013415 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 932677013416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677013417 Walker A motif; other site 932677013418 ATP binding site [chemical binding]; other site 932677013419 Walker B motif; other site 932677013420 arginine finger; other site 932677013421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 932677013422 Walker A motif; other site 932677013423 ATP binding site [chemical binding]; other site 932677013424 Walker B motif; other site 932677013425 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 932677013426 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 932677013427 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 932677013428 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 932677013429 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 932677013430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 932677013431 Peptidase family M23; Region: Peptidase_M23; pfam01551 932677013432 potential frameshift: common BLAST hit: gi|296102172|ref|YP_003612318.1| type VI secretion system protein ImpL 932677013433 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 932677013434 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 932677013435 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 932677013436 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 932677013437 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 932677013438 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 932677013439 PAAR motif; Region: PAAR_motif; pfam05488 932677013440 PAAR motif; Region: PAAR_motif; pfam05488 932677013441 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 932677013442 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 932677013443 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 932677013444 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 932677013445 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 932677013446 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 932677013447 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 932677013448 ImpA domain protein; Region: DUF3702; pfam12486 932677013449 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 932677013450 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 932677013451 substrate binding site [chemical binding]; other site 932677013452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677013453 metabolite-proton symporter; Region: 2A0106; TIGR00883 932677013454 putative substrate translocation pore; other site 932677013455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 932677013456 Major Facilitator Superfamily; Region: MFS_1; pfam07690 932677013457 putative substrate translocation pore; other site 932677013458 potential frameshift: common BLAST hit: gi|291619676|ref|YP_003522418.1| Cdh 932677013459 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 932677013460 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 932677013461 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677013462 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677013463 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 932677013464 dimerization interface [polypeptide binding]; other site 932677013465 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 932677013466 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 932677013467 NAD(P) binding site [chemical binding]; other site 932677013468 active site 932677013469 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 932677013470 NADH(P)-binding; Region: NAD_binding_10; pfam13460 932677013471 NAD(P) binding site [chemical binding]; other site 932677013472 putative active site [active] 932677013473 fumarate hydratase; Provisional; Region: PRK15389 932677013474 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 932677013475 Fumarase C-terminus; Region: Fumerase_C; pfam05683 932677013476 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 932677013477 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 932677013478 transmembrane helices; other site 932677013479 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 932677013480 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 932677013481 putative active site [active] 932677013482 putative FMN binding site [chemical binding]; other site 932677013483 putative substrate binding site [chemical binding]; other site 932677013484 putative catalytic residue [active] 932677013485 FMN-binding domain; Region: FMN_bind; cl01081 932677013486 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 932677013487 L-aspartate oxidase; Provisional; Region: PRK06175 932677013488 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 932677013489 ApbE family; Region: ApbE; pfam02424 932677013490 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 932677013491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 932677013492 active site 932677013493 phosphorylation site [posttranslational modification] 932677013494 intermolecular recognition site; other site 932677013495 dimerization interface [polypeptide binding]; other site 932677013496 sensory histidine kinase DcuS; Provisional; Region: PRK11086 932677013497 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 932677013498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 932677013499 ATP binding site [chemical binding]; other site 932677013500 Mg2+ binding site [ion binding]; other site 932677013501 G-X-G motif; other site 932677013502 Uncharacterized conserved protein [Function unknown]; Region: COG5464 932677013503 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 932677013504 malate:quinone oxidoreductase; Validated; Region: PRK05257 932677013505 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 932677013506 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 932677013507 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 932677013508 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 932677013509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677013510 catalytic residue [active] 932677013511 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 932677013512 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 932677013513 inhibitor-cofactor binding pocket; inhibition site 932677013514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 932677013515 catalytic residue [active] 932677013516 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 932677013517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932677013518 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 932677013519 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 932677013520 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 932677013521 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 932677013522 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 932677013523 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 932677013524 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 932677013525 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 932677013526 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 932677013527 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 932677013528 Cytochrome c; Region: Cytochrom_C; pfam00034 932677013529 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 932677013530 Cytochrome c; Region: Cytochrom_C; pfam00034 932677013531 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932677013532 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932677013533 metal binding site [ion binding]; metal-binding site 932677013534 active site 932677013535 I-site; other site 932677013536 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 932677013537 dimer interface [polypeptide binding]; other site 932677013538 FMN binding site [chemical binding]; other site 932677013539 NADPH bind site [chemical binding]; other site 932677013540 LysE type translocator; Region: LysE; cl00565 932677013541 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 932677013542 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 932677013543 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 932677013544 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932677013545 dimerization interface [polypeptide binding]; other site 932677013546 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 932677013547 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677013548 dimer interface [polypeptide binding]; other site 932677013549 putative CheW interface [polypeptide binding]; other site 932677013550 EamA-like transporter family; Region: EamA; pfam00892 932677013551 EamA-like transporter family; Region: EamA; pfam00892 932677013552 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 932677013553 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932677013554 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 932677013555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 932677013556 Walker A/P-loop; other site 932677013557 ATP binding site [chemical binding]; other site 932677013558 Q-loop/lid; other site 932677013559 ABC transporter signature motif; other site 932677013560 Walker B; other site 932677013561 D-loop; other site 932677013562 H-loop/switch region; other site 932677013563 TOBE domain; Region: TOBE_2; pfam08402 932677013564 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 932677013565 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 932677013566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 932677013567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677013568 putative PBP binding loops; other site 932677013569 ABC-ATPase subunit interface; other site 932677013570 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 932677013571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677013572 dimer interface [polypeptide binding]; other site 932677013573 conserved gate region; other site 932677013574 putative PBP binding loops; other site 932677013575 ABC-ATPase subunit interface; other site 932677013576 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 932677013577 active site 932677013578 metal binding site [ion binding]; metal-binding site 932677013579 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 932677013580 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677013581 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677013582 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 932677013583 dimerization interface [polypeptide binding]; other site 932677013584 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 932677013585 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 932677013586 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 932677013587 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 932677013588 catalytic triad [active] 932677013589 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 932677013590 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 932677013591 DsbD alpha interface [polypeptide binding]; other site 932677013592 catalytic residues [active] 932677013593 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 932677013594 aspartate racemase; Region: asp_race; TIGR00035 932677013595 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 932677013596 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 932677013597 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 932677013598 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 932677013599 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 932677013600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677013601 dimer interface [polypeptide binding]; other site 932677013602 conserved gate region; other site 932677013603 putative PBP binding loops; other site 932677013604 ABC-ATPase subunit interface; other site 932677013605 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 932677013606 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 932677013607 Walker A/P-loop; other site 932677013608 ATP binding site [chemical binding]; other site 932677013609 Q-loop/lid; other site 932677013610 ABC transporter signature motif; other site 932677013611 Walker B; other site 932677013612 D-loop; other site 932677013613 H-loop/switch region; other site 932677013614 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 932677013615 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 932677013616 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 932677013617 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 932677013618 urea carboxylase; Region: urea_carbox; TIGR02712 932677013619 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 932677013620 ATP-grasp domain; Region: ATP-grasp_4; cl17255 932677013621 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 932677013622 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 932677013623 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 932677013624 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 932677013625 carboxyltransferase (CT) interaction site; other site 932677013626 biotinylation site [posttranslational modification]; other site 932677013627 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 932677013628 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 932677013629 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 932677013630 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 932677013631 synthetase active site [active] 932677013632 NTP binding site [chemical binding]; other site 932677013633 metal binding site [ion binding]; metal-binding site 932677013634 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 932677013635 active site 932677013636 DNA binding site [nucleotide binding] 932677013637 Int/Topo IB signature motif; other site 932677013638 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 932677013639 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 932677013640 dimerization interface [polypeptide binding]; other site 932677013641 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 932677013642 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677013643 dimer interface [polypeptide binding]; other site 932677013644 putative CheW interface [polypeptide binding]; other site 932677013645 flagellin; Provisional; Region: PRK12802 932677013646 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 932677013647 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 932677013648 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 932677013649 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 932677013650 dimer interface [polypeptide binding]; other site 932677013651 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 932677013652 putative CheW interface [polypeptide binding]; other site 932677013653 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 932677013654 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 932677013655 Walker A/P-loop; other site 932677013656 ATP binding site [chemical binding]; other site 932677013657 Q-loop/lid; other site 932677013658 ABC transporter signature motif; other site 932677013659 Walker B; other site 932677013660 D-loop; other site 932677013661 H-loop/switch region; other site 932677013662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677013663 dimer interface [polypeptide binding]; other site 932677013664 conserved gate region; other site 932677013665 putative PBP binding loops; other site 932677013666 ABC-ATPase subunit interface; other site 932677013667 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 932677013668 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 932677013669 substrate binding pocket [chemical binding]; other site 932677013670 membrane-bound complex binding site; other site 932677013671 hinge residues; other site 932677013672 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 932677013673 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 932677013674 non-specific DNA binding site [nucleotide binding]; other site 932677013675 salt bridge; other site 932677013676 sequence-specific DNA binding site [nucleotide binding]; other site 932677013677 Cupin domain; Region: Cupin_2; pfam07883 932677013678 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 932677013679 hydroxyglutarate oxidase; Provisional; Region: PRK11728 932677013680 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 932677013681 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 932677013682 Metal-binding active site; metal-binding site 932677013683 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 932677013684 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 932677013685 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 932677013686 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 932677013687 Transcriptional regulators [Transcription]; Region: PurR; COG1609 932677013688 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 932677013689 domain linker motif; other site 932677013690 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 932677013691 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 932677013692 PAS domain; Region: PAS_9; pfam13426 932677013693 putative active site [active] 932677013694 heme pocket [chemical binding]; other site 932677013695 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 932677013696 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 932677013697 metal binding site [ion binding]; metal-binding site 932677013698 active site 932677013699 I-site; other site 932677013700 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 932677013701 Transcriptional regulator [Transcription]; Region: LysR; COG0583 932677013702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 932677013703 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 932677013704 dimerization interface [polypeptide binding]; other site 932677013705 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 932677013706 SxDxEG motif; other site 932677013707 active site 932677013708 metal binding site [ion binding]; metal-binding site 932677013709 homopentamer interface [polypeptide binding]; other site 932677013710 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 932677013711 homodimer interface [polypeptide binding]; other site 932677013712 homotetramer interface [polypeptide binding]; other site 932677013713 active site pocket [active] 932677013714 cleavage site 932677013715 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 932677013716 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 932677013717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677013718 dimer interface [polypeptide binding]; other site 932677013719 conserved gate region; other site 932677013720 putative PBP binding loops; other site 932677013721 ABC-ATPase subunit interface; other site 932677013722 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 932677013723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 932677013724 dimer interface [polypeptide binding]; other site 932677013725 conserved gate region; other site 932677013726 putative PBP binding loops; other site 932677013727 ABC-ATPase subunit interface; other site 932677013728 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 932677013729 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 932677013730 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 932677013731 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932677013732 Walker A/P-loop; other site 932677013733 ATP binding site [chemical binding]; other site 932677013734 Q-loop/lid; other site 932677013735 ABC transporter signature motif; other site 932677013736 Walker B; other site 932677013737 D-loop; other site 932677013738 H-loop/switch region; other site 932677013739 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 932677013740 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 932677013741 Walker A/P-loop; other site 932677013742 ATP binding site [chemical binding]; other site 932677013743 Q-loop/lid; other site 932677013744 ABC transporter signature motif; other site 932677013745 Walker B; other site 932677013746 D-loop; other site 932677013747 H-loop/switch region; other site 932677013748 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 932677013749 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 932677013750 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 932677013751 active site 932677013752 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 932677013753 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 932677013754 Flavin Reductases; Region: FlaRed; cl00801 932677013755 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 932677013756 putative FMN binding site [chemical binding]; other site 932677013757 pyrimidine utilization protein D; Region: RutD; TIGR03611 932677013758 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 932677013759 homotrimer interaction site [polypeptide binding]; other site 932677013760 putative active site [active] 932677013761 Isochorismatase family; Region: Isochorismatase; pfam00857 932677013762 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 932677013763 catalytic triad [active] 932677013764 conserved cis-peptide bond; other site 932677013765 pyrimidine utilization protein A; Region: RutA; TIGR03612 932677013766 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 932677013767 active site 932677013768 dimer interface [polypeptide binding]; other site 932677013769 non-prolyl cis peptide bond; other site 932677013770 insertion regions; other site 932677013771 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 932677013772 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 932677013773 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 932677013774 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 932677013775 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 932677013776 RES domain; Region: RES; pfam08808 932677013777 flagellar capping protein; Reviewed; Region: fliD; PRK08032 932677013778 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 932677013779 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 932677013780 flagellin; Provisional; Region: PRK12802 932677013781 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 932677013782 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 932677013783 Predicted flavoprotein [General function prediction only]; Region: COG0431 932677013784 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 932677013785 Domain of unknown function (DUF333); Region: DUF333; pfam03891 932677013786 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 932677013787 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 932677013788 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 932677013789 Peptidase family M23; Region: Peptidase_M23; pfam01551 932677013790 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 932677013791 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 932677013792 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 932677013793 catalytic residues [active] 932677013794 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 932677013795 Domain interface; other site 932677013796 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 932677013797 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 932677013798 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 932677013799 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 932677013800 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 932677013801 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 932677013802 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 932677013803 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 932677013804 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 932677013805 nucleotide binding site [chemical binding]; other site 932677013806 Protein of unknown function, DUF606; Region: DUF606; pfam04657 932677013807 potential frameshift: common BLAST hit: gi|333931673|ref|YP_004505251.1| Manganese transport protein mntH 932677013808 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 932677013809 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 932677013810 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 932677013811 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 932677013812 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 932677013813 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677013814 Coenzyme A binding pocket [chemical binding]; other site 932677013815 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 932677013816 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 932677013817 phosphate binding site [ion binding]; other site 932677013818 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 932677013819 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 932677013820 Coenzyme A binding pocket [chemical binding]; other site 932677013821 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 932677013822 Putative glucoamylase; Region: Glycoamylase; pfam10091 932677013823 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 932677013824 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 932677013825 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 932677013826 chorismate mutase; Provisional; Region: PRK08055