-- dump date 20140619_230717 -- class Genbank::misc_feature -- table misc_feature_note -- id note 706191000001 putative transporter; Provisional; Region: PRK10504 706191000002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191000003 putative substrate translocation pore; other site 706191000004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191000005 transcriptional repressor RbsR; Provisional; Region: PRK10423 706191000006 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191000007 DNA binding site [nucleotide binding] 706191000008 domain linker motif; other site 706191000009 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 706191000010 dimerization interface [polypeptide binding]; other site 706191000011 ligand binding site [chemical binding]; other site 706191000012 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 706191000013 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 706191000014 substrate binding site [chemical binding]; other site 706191000015 dimer interface [polypeptide binding]; other site 706191000016 ATP binding site [chemical binding]; other site 706191000017 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 706191000018 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 706191000019 ligand binding site [chemical binding]; other site 706191000020 dimerization interface [polypeptide binding]; other site 706191000021 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706191000022 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 706191000023 TM-ABC transporter signature motif; other site 706191000024 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 706191000025 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 706191000026 Walker A/P-loop; other site 706191000027 ATP binding site [chemical binding]; other site 706191000028 Q-loop/lid; other site 706191000029 ABC transporter signature motif; other site 706191000030 Walker B; other site 706191000031 D-loop; other site 706191000032 H-loop/switch region; other site 706191000033 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 706191000034 D-ribose pyranase; Provisional; Region: PRK11797 706191000035 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 706191000036 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 706191000037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191000038 active site 706191000039 phosphorylation site [posttranslational modification] 706191000040 intermolecular recognition site; other site 706191000041 dimerization interface [polypeptide binding]; other site 706191000042 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706191000043 DNA binding site [nucleotide binding] 706191000044 sensor protein QseC; Provisional; Region: PRK10337 706191000045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706191000046 dimer interface [polypeptide binding]; other site 706191000047 phosphorylation site [posttranslational modification] 706191000048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191000049 ATP binding site [chemical binding]; other site 706191000050 Mg2+ binding site [ion binding]; other site 706191000051 G-X-G motif; other site 706191000052 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 706191000053 potassium uptake protein; Region: kup; TIGR00794 706191000054 regulatory ATPase RavA; Provisional; Region: PRK13531 706191000055 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191000056 Walker A motif; other site 706191000057 ATP binding site [chemical binding]; other site 706191000058 Walker B motif; other site 706191000059 arginine finger; other site 706191000060 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 706191000061 hypothetical protein; Provisional; Region: yieM; PRK10997 706191000062 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 706191000063 metal ion-dependent adhesion site (MIDAS); other site 706191000064 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 706191000065 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 706191000066 Methyltransferase domain; Region: Methyltransf_31; pfam13847 706191000067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191000068 S-adenosylmethionine binding site [chemical binding]; other site 706191000069 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 706191000070 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706191000071 putative DNA binding site [nucleotide binding]; other site 706191000072 putative Zn2+ binding site [ion binding]; other site 706191000073 AsnC family; Region: AsnC_trans_reg; pfam01037 706191000074 FMN-binding protein MioC; Provisional; Region: PRK09004 706191000075 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 706191000076 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 706191000077 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 706191000078 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 706191000079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191000080 S-adenosylmethionine binding site [chemical binding]; other site 706191000081 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 706191000082 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 706191000083 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 706191000084 ATP synthase, F0 subunit c; Region: ATP_synt_c; TIGR01260 706191000085 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 706191000086 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 706191000087 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 706191000088 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 706191000089 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 706191000090 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 706191000091 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 706191000092 Walker A motif; other site 706191000093 ATP binding site [chemical binding]; other site 706191000094 Walker B motif; other site 706191000095 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 706191000096 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 706191000097 core domain interface [polypeptide binding]; other site 706191000098 delta subunit interface [polypeptide binding]; other site 706191000099 epsilon subunit interface [polypeptide binding]; other site 706191000100 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 706191000101 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 706191000102 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 706191000103 alpha subunit interaction interface [polypeptide binding]; other site 706191000104 Walker A motif; other site 706191000105 ATP binding site [chemical binding]; other site 706191000106 Walker B motif; other site 706191000107 inhibitor binding site; inhibition site 706191000108 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 706191000109 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 706191000110 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 706191000111 gamma subunit interface [polypeptide binding]; other site 706191000112 epsilon subunit interface [polypeptide binding]; other site 706191000113 LBP interface [polypeptide binding]; other site 706191000114 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 706191000115 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 706191000116 Substrate binding site; other site 706191000117 Mg++ binding site; other site 706191000118 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 706191000119 active site 706191000120 substrate binding site [chemical binding]; other site 706191000121 CoA binding site [chemical binding]; other site 706191000122 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 706191000123 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 706191000124 glutaminase active site [active] 706191000125 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 706191000126 dimer interface [polypeptide binding]; other site 706191000127 active site 706191000128 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 706191000129 dimer interface [polypeptide binding]; other site 706191000130 active site 706191000131 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 706191000132 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191000133 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 706191000134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191000135 dimer interface [polypeptide binding]; other site 706191000136 conserved gate region; other site 706191000137 putative PBP binding loops; other site 706191000138 ABC-ATPase subunit interface; other site 706191000139 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 706191000140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191000141 dimer interface [polypeptide binding]; other site 706191000142 conserved gate region; other site 706191000143 putative PBP binding loops; other site 706191000144 ABC-ATPase subunit interface; other site 706191000145 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 706191000146 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 706191000147 Walker A/P-loop; other site 706191000148 ATP binding site [chemical binding]; other site 706191000149 Q-loop/lid; other site 706191000150 ABC transporter signature motif; other site 706191000151 Walker B; other site 706191000152 D-loop; other site 706191000153 H-loop/switch region; other site 706191000154 transcriptional regulator PhoU; Provisional; Region: PRK11115 706191000155 PhoU domain; Region: PhoU; pfam01895 706191000156 PhoU domain; Region: PhoU; pfam01895 706191000157 benzoate transport; Region: 2A0115; TIGR00895 706191000158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191000159 putative substrate translocation pore; other site 706191000160 xylulokinase; Provisional; Region: PRK15027 706191000161 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 706191000162 N- and C-terminal domain interface [polypeptide binding]; other site 706191000163 active site 706191000164 MgATP binding site [chemical binding]; other site 706191000165 catalytic site [active] 706191000166 metal binding site [ion binding]; metal-binding site 706191000167 xylulose binding site [chemical binding]; other site 706191000168 homodimer interface [polypeptide binding]; other site 706191000169 xylose isomerase; Provisional; Region: PRK05474 706191000170 xylose isomerase; Region: xylose_isom_A; TIGR02630 706191000171 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 706191000172 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 706191000173 putative ligand binding site [chemical binding]; other site 706191000174 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 706191000175 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 706191000176 Walker A/P-loop; other site 706191000177 ATP binding site [chemical binding]; other site 706191000178 Q-loop/lid; other site 706191000179 ABC transporter signature motif; other site 706191000180 Walker B; other site 706191000181 D-loop; other site 706191000182 H-loop/switch region; other site 706191000183 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 706191000184 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 706191000185 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706191000186 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 706191000187 TM-ABC transporter signature motif; other site 706191000188 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 706191000189 putative dimerization interface [polypeptide binding]; other site 706191000190 Transcriptional regulators [Transcription]; Region: PurR; COG1609 706191000191 putative ligand binding site [chemical binding]; other site 706191000192 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191000193 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 706191000194 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191000195 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 706191000196 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191000197 Coenzyme A binding pocket [chemical binding]; other site 706191000198 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 706191000199 active site 706191000200 catalytic residues [active] 706191000201 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 706191000202 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 706191000203 ligand binding site [chemical binding]; other site 706191000204 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 706191000205 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 706191000206 Walker A/P-loop; other site 706191000207 ATP binding site [chemical binding]; other site 706191000208 Q-loop/lid; other site 706191000209 ABC transporter signature motif; other site 706191000210 Walker B; other site 706191000211 D-loop; other site 706191000212 H-loop/switch region; other site 706191000213 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 706191000214 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 706191000215 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706191000216 TM-ABC transporter signature motif; other site 706191000217 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706191000218 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 706191000219 TM-ABC transporter signature motif; other site 706191000220 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 706191000221 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 706191000222 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 706191000223 putative active site [active] 706191000224 OsmC-like protein; Region: OsmC; cl00767 706191000225 H+ Antiporter protein; Region: 2A0121; TIGR00900 706191000226 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 706191000227 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cl00723 706191000228 Putative motility protein; Region: YjfB_motility; pfam14070 706191000229 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 706191000230 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706191000231 PAS domain; Region: PAS_9; pfam13426 706191000232 putative active site [active] 706191000233 heme pocket [chemical binding]; other site 706191000234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706191000235 PAS domain; Region: PAS_9; pfam13426 706191000236 putative active site [active] 706191000237 heme pocket [chemical binding]; other site 706191000238 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191000239 dimer interface [polypeptide binding]; other site 706191000240 putative CheW interface [polypeptide binding]; other site 706191000241 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191000242 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191000243 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 706191000244 putative dimerization interface [polypeptide binding]; other site 706191000245 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 706191000246 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 706191000247 citrate-proton symporter; Provisional; Region: PRK15075 706191000248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191000249 putative substrate translocation pore; other site 706191000250 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 706191000251 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 706191000252 methionine cluster; other site 706191000253 active site 706191000254 phosphorylation site [posttranslational modification] 706191000255 metal binding site [ion binding]; metal-binding site 706191000256 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 706191000257 beta-galactosidase; Region: BGL; TIGR03356 706191000258 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 706191000259 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 706191000260 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 706191000261 active site 706191000262 P-loop; other site 706191000263 phosphorylation site [posttranslational modification] 706191000264 Transcriptional regulators [Transcription]; Region: PurR; COG1609 706191000265 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191000266 DNA binding site [nucleotide binding] 706191000267 domain linker motif; other site 706191000268 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 706191000269 ligand binding site [chemical binding]; other site 706191000270 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 706191000271 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 706191000272 DNA replication protein DnaC; Validated; Region: PRK07952 706191000273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191000274 Walker A motif; other site 706191000275 ATP binding site [chemical binding]; other site 706191000276 Walker B motif; other site 706191000277 primosomal protein DnaI; Provisional; Region: PRK02854 706191000278 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 706191000279 putative outer membrane lipoprotein; Provisional; Region: PRK10510 706191000280 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 706191000281 ligand binding site [chemical binding]; other site 706191000282 Transcriptional regulators [Transcription]; Region: PurR; COG1609 706191000283 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191000284 DNA binding site [nucleotide binding] 706191000285 domain linker motif; other site 706191000286 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 706191000287 ligand binding site [chemical binding]; other site 706191000288 Transcriptional regulators [Transcription]; Region: PurR; COG1609 706191000289 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191000290 DNA binding site [nucleotide binding] 706191000291 domain linker motif; other site 706191000292 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 706191000293 putative dimerization interface [polypeptide binding]; other site 706191000294 putative ligand binding site [chemical binding]; other site 706191000295 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 706191000296 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 706191000297 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 706191000298 substrate binding site [chemical binding]; other site 706191000299 ATP binding site [chemical binding]; other site 706191000300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191000301 D-galactonate transporter; Region: 2A0114; TIGR00893 706191000302 putative substrate translocation pore; other site 706191000303 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 706191000304 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 706191000305 dimerization interface [polypeptide binding]; other site 706191000306 ligand binding site [chemical binding]; other site 706191000307 NADP binding site [chemical binding]; other site 706191000308 catalytic site [active] 706191000309 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 706191000310 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706191000311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191000312 homodimer interface [polypeptide binding]; other site 706191000313 catalytic residue [active] 706191000314 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 706191000315 EamA-like transporter family; Region: EamA; pfam00892 706191000316 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 706191000317 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 706191000318 active site 706191000319 Uncharacterized conserved protein [Function unknown]; Region: COG5464 706191000320 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 706191000321 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 706191000322 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 706191000323 putative dimer interface [polypeptide binding]; other site 706191000324 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 706191000325 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 706191000326 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 706191000327 sugar phosphate phosphatase; Provisional; Region: PRK10513 706191000328 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191000329 active site 706191000330 motif I; other site 706191000331 motif II; other site 706191000332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191000333 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 706191000334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191000335 Mg2+ binding site [ion binding]; other site 706191000336 G-X-G motif; other site 706191000337 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 706191000338 anchoring element; other site 706191000339 dimer interface [polypeptide binding]; other site 706191000340 ATP binding site [chemical binding]; other site 706191000341 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 706191000342 active site 706191000343 putative metal-binding site [ion binding]; other site 706191000344 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 706191000345 recF protein; Region: recf; TIGR00611 706191000346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191000347 Walker A/P-loop; other site 706191000348 ATP binding site [chemical binding]; other site 706191000349 Q-loop/lid; other site 706191000350 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191000351 ABC transporter signature motif; other site 706191000352 Walker B; other site 706191000353 D-loop; other site 706191000354 H-loop/switch region; other site 706191000355 DNA polymerase III subunit beta; Validated; Region: PRK05643 706191000356 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 706191000357 putative DNA binding surface [nucleotide binding]; other site 706191000358 dimer interface [polypeptide binding]; other site 706191000359 beta-clamp/clamp loader binding surface; other site 706191000360 beta-clamp/translesion DNA polymerase binding surface; other site 706191000361 DnaA N-terminal domain; Region: DnaA_N; pfam11638 706191000362 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 706191000363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191000364 Walker A motif; other site 706191000365 ATP binding site [chemical binding]; other site 706191000366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 706191000367 Walker B motif; other site 706191000368 arginine finger; other site 706191000369 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 706191000370 DnaA box-binding interface [nucleotide binding]; other site 706191000371 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 706191000372 ribonuclease P; Reviewed; Region: rnpA; PRK01732 706191000373 membrane protein insertase; Provisional; Region: PRK01318 706191000374 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 706191000375 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 706191000376 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 706191000377 trmE is a tRNA modification GTPase; Region: trmE; cd04164 706191000378 G1 box; other site 706191000379 GTP/Mg2+ binding site [chemical binding]; other site 706191000380 Switch I region; other site 706191000381 G2 box; other site 706191000382 Switch II region; other site 706191000383 G3 box; other site 706191000384 G4 box; other site 706191000385 G5 box; other site 706191000386 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 706191000387 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 706191000388 putative FMN binding site [chemical binding]; other site 706191000389 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 706191000390 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 706191000391 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 706191000392 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 706191000393 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191000394 active site 706191000395 motif I; other site 706191000396 motif II; other site 706191000397 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 706191000398 Acyltransferase family; Region: Acyl_transf_3; pfam01757 706191000399 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 706191000400 dimer interface [polypeptide binding]; other site 706191000401 motif 1; other site 706191000402 active site 706191000403 motif 2; other site 706191000404 motif 3; other site 706191000405 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 706191000406 DALR anticodon binding domain; Region: DALR_1; pfam05746 706191000407 MltA-interacting protein MipA; Region: MipA; cl01504 706191000408 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 706191000409 putative glutathione S-transferase; Provisional; Region: PRK10357 706191000410 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 706191000411 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 706191000412 dimer interface [polypeptide binding]; other site 706191000413 N-terminal domain interface [polypeptide binding]; other site 706191000414 putative substrate binding pocket (H-site) [chemical binding]; other site 706191000415 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 706191000416 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 706191000417 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 706191000418 superoxide dismutase; Provisional; Region: PRK10925 706191000419 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 706191000420 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 706191000421 Protein of unknown function (DUF535); Region: DUF535; pfam04393 706191000422 hypothetical protein; Provisional; Region: PRK11020 706191000423 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 706191000424 Mannitol repressor; Region: MtlR; cl11450 706191000425 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 706191000426 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 706191000427 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 706191000428 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 706191000429 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 706191000430 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 706191000431 active site 706191000432 P-loop; other site 706191000433 phosphorylation site [posttranslational modification] 706191000434 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 706191000435 active site 706191000436 phosphorylation site [posttranslational modification] 706191000437 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 706191000438 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706191000439 non-specific DNA binding site [nucleotide binding]; other site 706191000440 salt bridge; other site 706191000441 sequence-specific DNA binding site [nucleotide binding]; other site 706191000442 tryptophan permease TnaB; Provisional; Region: PRK09664 706191000443 aromatic amino acid transport protein; Region: araaP; TIGR00837 706191000444 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 706191000445 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 706191000446 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 706191000447 catalytic residue [active] 706191000448 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 706191000449 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706191000450 Zn2+ binding site [ion binding]; other site 706191000451 Mg2+ binding site [ion binding]; other site 706191000452 Transcriptional regulators [Transcription]; Region: MarR; COG1846 706191000453 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706191000454 putative Zn2+ binding site [ion binding]; other site 706191000455 putative DNA binding site [nucleotide binding]; other site 706191000456 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 706191000457 phosphoethanolamine transferase; Provisional; Region: PRK11560 706191000458 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 706191000459 Sulfatase; Region: Sulfatase; pfam00884 706191000460 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 706191000461 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 706191000462 peptide binding site [polypeptide binding]; other site 706191000463 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 706191000464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191000465 dimer interface [polypeptide binding]; other site 706191000466 conserved gate region; other site 706191000467 putative PBP binding loops; other site 706191000468 ABC-ATPase subunit interface; other site 706191000469 dipeptide transporter; Provisional; Region: PRK10913 706191000470 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 706191000471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191000472 dimer interface [polypeptide binding]; other site 706191000473 conserved gate region; other site 706191000474 putative PBP binding loops; other site 706191000475 ABC-ATPase subunit interface; other site 706191000476 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 706191000477 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706191000478 Walker A/P-loop; other site 706191000479 ATP binding site [chemical binding]; other site 706191000480 Q-loop/lid; other site 706191000481 ABC transporter signature motif; other site 706191000482 Walker B; other site 706191000483 D-loop; other site 706191000484 H-loop/switch region; other site 706191000485 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 706191000486 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 706191000487 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706191000488 Walker A/P-loop; other site 706191000489 ATP binding site [chemical binding]; other site 706191000490 Q-loop/lid; other site 706191000491 ABC transporter signature motif; other site 706191000492 Walker B; other site 706191000493 D-loop; other site 706191000494 H-loop/switch region; other site 706191000495 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 706191000496 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 706191000497 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 706191000498 P-loop; other site 706191000499 Magnesium ion binding site [ion binding]; other site 706191000500 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 706191000501 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 706191000502 DXD motif; other site 706191000503 PilZ domain; Region: PilZ; pfam07238 706191000504 cellulose synthase regulator protein; Provisional; Region: PRK11114 706191000505 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 706191000506 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706191000507 binding surface 706191000508 TPR motif; other site 706191000509 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 706191000510 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 706191000511 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 706191000512 putative diguanylate cyclase; Provisional; Region: PRK13561 706191000513 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706191000514 metal binding site [ion binding]; metal-binding site 706191000515 active site 706191000516 I-site; other site 706191000517 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 706191000518 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 706191000519 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 706191000520 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 706191000521 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 706191000522 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 706191000523 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 706191000524 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 706191000525 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 706191000526 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 706191000527 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 706191000528 substrate binding site [chemical binding]; other site 706191000529 ATP binding site [chemical binding]; other site 706191000530 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 706191000531 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 706191000532 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 706191000533 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 706191000534 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 706191000535 Part of AAA domain; Region: AAA_19; pfam13245 706191000536 Family description; Region: UvrD_C_2; pfam13538 706191000537 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 706191000538 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 706191000539 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 706191000540 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 706191000541 ATP binding site [chemical binding]; other site 706191000542 Mg++ binding site [ion binding]; other site 706191000543 motif III; other site 706191000544 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 706191000545 nucleotide binding region [chemical binding]; other site 706191000546 ATP-binding site [chemical binding]; other site 706191000547 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 706191000548 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 706191000549 catalytic residues [active] 706191000550 transcription termination factor Rho; Provisional; Region: rho; PRK09376 706191000551 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 706191000552 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 706191000553 RNA binding site [nucleotide binding]; other site 706191000554 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 706191000555 multimer interface [polypeptide binding]; other site 706191000556 Walker A motif; other site 706191000557 ATP binding site [chemical binding]; other site 706191000558 Walker B motif; other site 706191000559 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 706191000560 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 706191000561 Mg++ binding site [ion binding]; other site 706191000562 putative catalytic motif [active] 706191000563 substrate binding site [chemical binding]; other site 706191000564 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 706191000565 Chain length determinant protein; Region: Wzz; pfam02706 706191000566 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 706191000567 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 706191000568 active site 706191000569 homodimer interface [polypeptide binding]; other site 706191000570 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 706191000571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 706191000572 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 706191000573 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 706191000574 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 706191000575 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 706191000576 NAD binding site [chemical binding]; other site 706191000577 substrate binding site [chemical binding]; other site 706191000578 homodimer interface [polypeptide binding]; other site 706191000579 active site 706191000580 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 706191000581 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 706191000582 substrate binding site; other site 706191000583 tetramer interface; other site 706191000584 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 706191000585 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191000586 Coenzyme A binding pocket [chemical binding]; other site 706191000587 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 706191000588 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 706191000589 inhibitor-cofactor binding pocket; inhibition site 706191000590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191000591 catalytic residue [active] 706191000592 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 706191000593 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 706191000594 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929 706191000595 putative common antigen polymerase; Provisional; Region: PRK02975 706191000596 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 706191000597 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 706191000598 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 706191000599 HemY protein N-terminus; Region: HemY_N; pfam07219 706191000600 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 706191000601 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 706191000602 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 706191000603 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 706191000604 active site 706191000605 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 706191000606 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 706191000607 active site 706191000608 domain interfaces; other site 706191000609 adenylate cyclase; Provisional; Region: cyaA; PRK09450 706191000610 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 706191000611 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 706191000612 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 706191000613 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 706191000614 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 706191000615 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 706191000616 hypothetical protein; Provisional; Region: PRK10963 706191000617 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 706191000618 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 706191000619 active site 706191000620 DNA binding site [nucleotide binding] 706191000621 Int/Topo IB signature motif; other site 706191000622 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 706191000623 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191000624 motif II; other site 706191000625 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 706191000626 Part of AAA domain; Region: AAA_19; pfam13245 706191000627 Family description; Region: UvrD_C_2; pfam13538 706191000628 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 706191000629 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 706191000630 Cl binding site [ion binding]; other site 706191000631 oligomer interface [polypeptide binding]; other site 706191000632 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 706191000633 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 706191000634 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 706191000635 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 706191000636 Predicted transcriptional regulators [Transcription]; Region: COG1733 706191000637 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706191000638 dimerization interface [polypeptide binding]; other site 706191000639 putative DNA binding site [nucleotide binding]; other site 706191000640 putative Zn2+ binding site [ion binding]; other site 706191000641 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 706191000642 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 706191000643 CoenzymeA binding site [chemical binding]; other site 706191000644 subunit interaction site [polypeptide binding]; other site 706191000645 PHB binding site; other site 706191000646 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 706191000647 dimerization interface [polypeptide binding]; other site 706191000648 substrate binding site [chemical binding]; other site 706191000649 active site 706191000650 calcium binding site [ion binding]; other site 706191000651 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 706191000652 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 706191000653 ATP binding site [chemical binding]; other site 706191000654 putative Mg++ binding site [ion binding]; other site 706191000655 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 706191000656 nucleotide binding region [chemical binding]; other site 706191000657 ATP-binding site [chemical binding]; other site 706191000658 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 706191000659 HRDC domain; Region: HRDC; pfam00570 706191000660 threonine efflux system; Provisional; Region: PRK10229 706191000661 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 706191000662 lysophospholipase L2; Provisional; Region: PRK10749 706191000663 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 706191000664 putative hydrolase; Provisional; Region: PRK10976 706191000665 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191000666 active site 706191000667 motif I; other site 706191000668 motif II; other site 706191000669 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191000670 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 706191000671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191000672 putative substrate translocation pore; other site 706191000673 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 706191000674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 706191000675 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 706191000676 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 706191000677 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 706191000678 putative dimerization interface [polypeptide binding]; other site 706191000679 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 706191000680 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 706191000681 THF binding site; other site 706191000682 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 706191000683 substrate binding site [chemical binding]; other site 706191000684 THF binding site; other site 706191000685 zinc-binding site [ion binding]; other site 706191000686 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 706191000687 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 706191000688 uridine phosphorylase; Provisional; Region: PRK11178 706191000689 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 706191000690 DNA recombination protein RmuC; Provisional; Region: PRK10361 706191000691 RmuC family; Region: RmuC; pfam02646 706191000692 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 706191000693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191000694 S-adenosylmethionine binding site [chemical binding]; other site 706191000695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 706191000696 SCP-2 sterol transfer family; Region: SCP2; pfam02036 706191000697 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 706191000698 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 706191000699 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 706191000700 sec-independent translocase; Provisional; Region: PRK01770 706191000701 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 706191000702 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 706191000703 active site 706191000704 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 706191000705 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 706191000706 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 706191000707 FMN reductase; Validated; Region: fre; PRK08051 706191000708 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 706191000709 FAD binding pocket [chemical binding]; other site 706191000710 FAD binding motif [chemical binding]; other site 706191000711 phosphate binding motif [ion binding]; other site 706191000712 beta-alpha-beta structure motif; other site 706191000713 NAD binding pocket [chemical binding]; other site 706191000714 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 706191000715 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 706191000716 dimer interface [polypeptide binding]; other site 706191000717 active site 706191000718 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 706191000719 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 706191000720 substrate binding site [chemical binding]; other site 706191000721 oxyanion hole (OAH) forming residues; other site 706191000722 trimer interface [polypeptide binding]; other site 706191000723 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 706191000724 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 706191000725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 706191000726 proline dipeptidase; Provisional; Region: PRK13607 706191000727 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 706191000728 active site 706191000729 hypothetical protein; Provisional; Region: PRK11568 706191000730 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 706191000731 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 706191000732 potassium transporter; Provisional; Region: PRK10750 706191000733 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 706191000734 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 706191000735 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 706191000736 FAD binding domain; Region: FAD_binding_4; pfam01565 706191000737 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 706191000738 Biotin operon repressor [Transcription]; Region: BirA; COG1654 706191000739 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 706191000740 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 706191000741 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 706191000742 pantothenate kinase; Provisional; Region: PRK05439 706191000743 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 706191000744 ATP-binding site [chemical binding]; other site 706191000745 CoA-binding site [chemical binding]; other site 706191000746 Mg2+-binding site [ion binding]; other site 706191000747 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 706191000748 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 706191000749 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 706191000750 putative homodimer interface [polypeptide binding]; other site 706191000751 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 706191000752 heterodimer interface [polypeptide binding]; other site 706191000753 homodimer interface [polypeptide binding]; other site 706191000754 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 706191000755 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 706191000756 23S rRNA interface [nucleotide binding]; other site 706191000757 L7/L12 interface [polypeptide binding]; other site 706191000758 putative thiostrepton binding site; other site 706191000759 L25 interface [polypeptide binding]; other site 706191000760 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 706191000761 mRNA/rRNA interface [nucleotide binding]; other site 706191000762 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 706191000763 23S rRNA interface [nucleotide binding]; other site 706191000764 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 706191000765 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 706191000766 L11 interface [polypeptide binding]; other site 706191000767 putative EF-Tu interaction site [polypeptide binding]; other site 706191000768 putative EF-G interaction site [polypeptide binding]; other site 706191000769 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 706191000770 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 706191000771 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 706191000772 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 706191000773 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 706191000774 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 706191000775 RPB3 interaction site [polypeptide binding]; other site 706191000776 RPB1 interaction site [polypeptide binding]; other site 706191000777 RPB11 interaction site [polypeptide binding]; other site 706191000778 RPB10 interaction site [polypeptide binding]; other site 706191000779 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 706191000780 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 706191000781 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 706191000782 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 706191000783 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 706191000784 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 706191000785 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 706191000786 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 706191000787 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 706191000788 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 706191000789 DNA binding site [nucleotide binding] 706191000790 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 706191000791 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 706191000792 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191000793 DNA-binding site [nucleotide binding]; DNA binding site 706191000794 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706191000795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191000796 homodimer interface [polypeptide binding]; other site 706191000797 catalytic residue [active] 706191000798 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 706191000799 thiamine phosphate binding site [chemical binding]; other site 706191000800 active site 706191000801 pyrophosphate binding site [ion binding]; other site 706191000802 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 706191000803 ThiC-associated domain; Region: ThiC-associated; pfam13667 706191000804 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 706191000805 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 706191000806 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 706191000807 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 706191000808 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 706191000809 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 706191000810 putative NADH binding site [chemical binding]; other site 706191000811 putative active site [active] 706191000812 nudix motif; other site 706191000813 putative metal binding site [ion binding]; other site 706191000814 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 706191000815 substrate binding site [chemical binding]; other site 706191000816 active site 706191000817 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 706191000818 Active_site [active] 706191000819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 706191000820 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 706191000821 IHF dimer interface [polypeptide binding]; other site 706191000822 IHF - DNA interface [nucleotide binding]; other site 706191000823 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 706191000824 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 706191000825 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 706191000826 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 706191000827 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 706191000828 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 706191000829 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 706191000830 purine monophosphate binding site [chemical binding]; other site 706191000831 dimer interface [polypeptide binding]; other site 706191000832 putative catalytic residues [active] 706191000833 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 706191000834 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 706191000835 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 706191000836 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 706191000837 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 706191000838 putative ligand binding residues [chemical binding]; other site 706191000839 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 706191000840 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 706191000841 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 706191000842 homoserine O-succinyltransferase; Provisional; Region: PRK05368 706191000843 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 706191000844 proposed active site lysine [active] 706191000845 conserved cys residue [active] 706191000846 malate synthase A; Region: malate_syn_A; TIGR01344 706191000847 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 706191000848 active site 706191000849 isocitrate lyase; Provisional; Region: PRK15063 706191000850 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 706191000851 tetramer interface [polypeptide binding]; other site 706191000852 active site 706191000853 Mg2+/Mn2+ binding site [ion binding]; other site 706191000854 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 706191000855 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 706191000856 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 706191000857 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191000858 DNA-binding site [nucleotide binding]; DNA binding site 706191000859 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 706191000860 putative outer membrane porin protein; Provisional; Region: PRK11379 706191000861 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 706191000862 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 706191000863 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 706191000864 Beta-lactamase; Region: Beta-lactamase; pfam00144 706191000865 transcriptional repressor IclR; Provisional; Region: PRK11569 706191000866 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 706191000867 Bacterial transcriptional regulator; Region: IclR; pfam01614 706191000868 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 706191000869 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 706191000870 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 706191000871 substrate binding pocket [chemical binding]; other site 706191000872 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 706191000873 B12 binding site [chemical binding]; other site 706191000874 cobalt ligand [ion binding]; other site 706191000875 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 706191000876 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 706191000877 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 706191000878 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 706191000879 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 706191000880 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 706191000881 active site 706191000882 dimer interface [polypeptide binding]; other site 706191000883 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 706191000884 dimer interface [polypeptide binding]; other site 706191000885 active site 706191000886 aspartate kinase III; Validated; Region: PRK09084 706191000887 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 706191000888 nucleotide binding site [chemical binding]; other site 706191000889 substrate binding site [chemical binding]; other site 706191000890 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 706191000891 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 706191000892 dimer interface [polypeptide binding]; other site 706191000893 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 706191000894 Sodium Bile acid symporter family; Region: SBF; pfam01758 706191000895 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 706191000896 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 706191000897 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 706191000898 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 706191000899 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 706191000900 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 706191000901 UbiA prenyltransferase family; Region: UbiA; pfam01040 706191000902 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 706191000903 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 706191000904 putative acyl-acceptor binding pocket; other site 706191000905 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 706191000906 LexA repressor; Validated; Region: PRK00215 706191000907 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 706191000908 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 706191000909 Catalytic site [active] 706191000910 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 706191000911 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 706191000912 hypothetical protein; Provisional; Region: PRK10428 706191000913 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 706191000914 metal binding site 2 [ion binding]; metal-binding site 706191000915 putative DNA binding helix; other site 706191000916 metal binding site 1 [ion binding]; metal-binding site 706191000917 dimer interface [polypeptide binding]; other site 706191000918 structural Zn2+ binding site [ion binding]; other site 706191000919 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 706191000920 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 706191000921 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 706191000922 FMN binding site [chemical binding]; other site 706191000923 active site 706191000924 catalytic residues [active] 706191000925 substrate binding site [chemical binding]; other site 706191000926 phage shock protein G; Reviewed; Region: pspG; PRK09459 706191000927 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 706191000928 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 706191000929 NADP binding site [chemical binding]; other site 706191000930 dimer interface [polypeptide binding]; other site 706191000931 replicative DNA helicase; Provisional; Region: PRK08006 706191000932 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 706191000933 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 706191000934 Walker A motif; other site 706191000935 ATP binding site [chemical binding]; other site 706191000936 Walker B motif; other site 706191000937 DNA binding loops [nucleotide binding] 706191000938 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 706191000939 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 706191000940 putative DNA binding site [nucleotide binding]; other site 706191000941 putative Zn2+ binding site [ion binding]; other site 706191000942 AsnC family; Region: AsnC_trans_reg; pfam01037 706191000943 Uncharacterized conserved protein [Function unknown]; Region: COG1284 706191000944 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 706191000945 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 706191000946 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706191000947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191000948 homodimer interface [polypeptide binding]; other site 706191000949 catalytic residue [active] 706191000950 Uncharacterized conserved protein [Function unknown]; Region: COG0432 706191000951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 706191000952 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 706191000953 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 706191000954 putative NAD(P) binding site [chemical binding]; other site 706191000955 putative substrate binding site [chemical binding]; other site 706191000956 catalytic Zn binding site [ion binding]; other site 706191000957 structural Zn binding site [ion binding]; other site 706191000958 dimer interface [polypeptide binding]; other site 706191000959 TIGR04076 family protein; Region: TIGR04076 706191000960 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 706191000961 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 706191000962 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 706191000963 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 706191000964 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 706191000965 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 706191000966 dimer interface [polypeptide binding]; other site 706191000967 ssDNA binding site [nucleotide binding]; other site 706191000968 tetramer (dimer of dimers) interface [polypeptide binding]; other site 706191000969 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 706191000970 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 706191000971 catalytic triad [active] 706191000972 conserved cis-peptide bond; other site 706191000973 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 706191000974 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 706191000975 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191000976 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 706191000977 DNA-binding interface [nucleotide binding]; DNA binding site 706191000978 Winged helix-turn helix; Region: HTH_29; pfam13551 706191000979 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 706191000980 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 706191000981 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 706191000982 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 706191000983 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191000984 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 706191000985 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 706191000986 DNA binding residues [nucleotide binding] 706191000987 dimer interface [polypeptide binding]; other site 706191000988 [2Fe-2S] cluster binding site [ion binding]; other site 706191000989 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 706191000990 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 706191000991 putative C-terminal domain interface [polypeptide binding]; other site 706191000992 putative GSH binding site (G-site) [chemical binding]; other site 706191000993 putative dimer interface [polypeptide binding]; other site 706191000994 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 706191000995 putative N-terminal domain interface [polypeptide binding]; other site 706191000996 putative dimer interface [polypeptide binding]; other site 706191000997 putative substrate binding pocket (H-site) [chemical binding]; other site 706191000998 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 706191000999 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 706191001000 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191001001 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191001002 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 706191001003 putative dimerization interface [polypeptide binding]; other site 706191001004 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 706191001005 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 706191001006 YfaZ precursor; Region: YfaZ; pfam07437 706191001007 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 706191001008 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 706191001009 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 706191001010 Na binding site [ion binding]; other site 706191001011 Predicted membrane protein [Function unknown]; Region: COG3162 706191001012 acetyl-CoA synthetase; Provisional; Region: PRK00174 706191001013 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 706191001014 active site 706191001015 CoA binding site [chemical binding]; other site 706191001016 acyl-activating enzyme (AAE) consensus motif; other site 706191001017 AMP binding site [chemical binding]; other site 706191001018 acetate binding site [chemical binding]; other site 706191001019 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 706191001020 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 706191001021 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 706191001022 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 706191001023 putative active site [active] 706191001024 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 706191001025 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 706191001026 active site turn [active] 706191001027 phosphorylation site [posttranslational modification] 706191001028 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 706191001029 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706191001030 PAS domain; Region: PAS_9; pfam13426 706191001031 putative active site [active] 706191001032 heme pocket [chemical binding]; other site 706191001033 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706191001034 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191001035 dimer interface [polypeptide binding]; other site 706191001036 putative CheW interface [polypeptide binding]; other site 706191001037 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 706191001038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191001039 putative substrate translocation pore; other site 706191001040 microcin B17 transporter; Reviewed; Region: PRK11098 706191001041 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 706191001042 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 706191001043 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706191001044 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 706191001045 Cytochrome c; Region: Cytochrom_C; pfam00034 706191001046 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 706191001047 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 706191001048 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 706191001049 benzoate transport; Region: 2A0115; TIGR00895 706191001050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191001051 putative substrate translocation pore; other site 706191001052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191001053 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 706191001054 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706191001055 dimerization interface [polypeptide binding]; other site 706191001056 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191001057 dimer interface [polypeptide binding]; other site 706191001058 putative CheW interface [polypeptide binding]; other site 706191001059 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 706191001060 dimer interface [polypeptide binding]; other site 706191001061 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 706191001062 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 706191001063 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706191001064 dimer interface [polypeptide binding]; other site 706191001065 phosphorylation site [posttranslational modification] 706191001066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191001067 ATP binding site [chemical binding]; other site 706191001068 Mg2+ binding site [ion binding]; other site 706191001069 G-X-G motif; other site 706191001070 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 706191001071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191001072 active site 706191001073 phosphorylation site [posttranslational modification] 706191001074 intermolecular recognition site; other site 706191001075 dimerization interface [polypeptide binding]; other site 706191001076 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706191001077 DNA binding site [nucleotide binding] 706191001078 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 706191001079 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191001080 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191001081 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191001082 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191001083 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 706191001084 putative effector binding pocket; other site 706191001085 dimerization interface [polypeptide binding]; other site 706191001086 drug efflux system protein MdtG; Provisional; Region: PRK09874 706191001087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191001088 putative substrate translocation pore; other site 706191001089 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 706191001090 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 706191001091 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 706191001092 Trp docking motif [polypeptide binding]; other site 706191001093 putative active site [active] 706191001094 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 706191001095 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 706191001096 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 706191001097 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 706191001098 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 706191001099 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 706191001100 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 706191001101 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191001102 Walker A/P-loop; other site 706191001103 ATP binding site [chemical binding]; other site 706191001104 Q-loop/lid; other site 706191001105 ABC transporter signature motif; other site 706191001106 Walker B; other site 706191001107 D-loop; other site 706191001108 H-loop/switch region; other site 706191001109 TOBE domain; Region: TOBE_2; pfam08402 706191001110 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 706191001111 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 706191001112 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 706191001113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191001114 dimer interface [polypeptide binding]; other site 706191001115 conserved gate region; other site 706191001116 putative PBP binding loops; other site 706191001117 ABC-ATPase subunit interface; other site 706191001118 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 706191001119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191001120 dimer interface [polypeptide binding]; other site 706191001121 conserved gate region; other site 706191001122 putative PBP binding loops; other site 706191001123 ABC-ATPase subunit interface; other site 706191001124 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 706191001125 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 706191001126 tartrate dehydrogenase; Region: TTC; TIGR02089 706191001127 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191001128 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 706191001129 dimerization interface [polypeptide binding]; other site 706191001130 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706191001131 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191001132 dimer interface [polypeptide binding]; other site 706191001133 putative CheW interface [polypeptide binding]; other site 706191001134 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 706191001135 putative S-transferase; Provisional; Region: PRK11752 706191001136 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 706191001137 C-terminal domain interface [polypeptide binding]; other site 706191001138 GSH binding site (G-site) [chemical binding]; other site 706191001139 dimer interface [polypeptide binding]; other site 706191001140 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 706191001141 N-terminal domain interface [polypeptide binding]; other site 706191001142 dimer interface [polypeptide binding]; other site 706191001143 substrate binding pocket (H-site) [chemical binding]; other site 706191001144 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 706191001145 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 706191001146 putative substrate binding site [chemical binding]; other site 706191001147 putative ATP binding site [chemical binding]; other site 706191001148 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 706191001149 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 706191001150 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 706191001151 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 706191001152 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 706191001153 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 706191001154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191001155 putative substrate translocation pore; other site 706191001156 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 706191001157 trimer interface; other site 706191001158 sugar binding site [chemical binding]; other site 706191001159 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 706191001160 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 706191001161 active site turn [active] 706191001162 phosphorylation site [posttranslational modification] 706191001163 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 706191001164 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 706191001165 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 706191001166 substrate binding [chemical binding]; other site 706191001167 active site 706191001168 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 706191001169 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 706191001170 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191001171 DNA binding site [nucleotide binding] 706191001172 domain linker motif; other site 706191001173 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 706191001174 dimerization interface [polypeptide binding]; other site 706191001175 ligand binding site [chemical binding]; other site 706191001176 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 706191001177 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 706191001178 dimerization domain [polypeptide binding]; other site 706191001179 dimer interface [polypeptide binding]; other site 706191001180 catalytic residues [active] 706191001181 Predicted transporter component [General function prediction only]; Region: COG2391 706191001182 Predicted transporter component [General function prediction only]; Region: COG2391 706191001183 Putative phosphatase (DUF442); Region: DUF442; cl17385 706191001184 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 706191001185 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 706191001186 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 706191001187 DsrE/DsrF-like family; Region: DrsE; cl00672 706191001188 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 706191001189 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191001190 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191001191 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 706191001192 dimerization interface [polypeptide binding]; other site 706191001193 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 706191001194 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 706191001195 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 706191001196 FAD binding pocket [chemical binding]; other site 706191001197 FAD binding motif [chemical binding]; other site 706191001198 phosphate binding motif [ion binding]; other site 706191001199 NAD binding pocket [chemical binding]; other site 706191001200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191001201 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706191001202 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 706191001203 IucA / IucC family; Region: IucA_IucC; pfam04183 706191001204 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 706191001205 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 706191001206 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 706191001207 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 706191001208 IucA / IucC family; Region: IucA_IucC; pfam04183 706191001209 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 706191001210 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 706191001211 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706191001212 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 706191001213 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 706191001214 N-terminal plug; other site 706191001215 ligand-binding site [chemical binding]; other site 706191001216 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706191001217 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191001218 dimer interface [polypeptide binding]; other site 706191001219 putative CheW interface [polypeptide binding]; other site 706191001220 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 706191001221 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 706191001222 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 706191001223 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 706191001224 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 706191001225 intersubunit interface [polypeptide binding]; other site 706191001226 active site 706191001227 Zn2+ binding site [ion binding]; other site 706191001228 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 706191001229 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 706191001230 AP (apurinic/apyrimidinic) site pocket; other site 706191001231 DNA interaction; other site 706191001232 Metal-binding active site; metal-binding site 706191001233 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 706191001234 active site 706191001235 magnesium binding site [ion binding]; other site 706191001236 dimer interface [polypeptide binding]; other site 706191001237 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 706191001238 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 706191001239 putative N- and C-terminal domain interface [polypeptide binding]; other site 706191001240 putative active site [active] 706191001241 MgATP binding site [chemical binding]; other site 706191001242 catalytic site [active] 706191001243 metal binding site [ion binding]; metal-binding site 706191001244 putative xylulose binding site [chemical binding]; other site 706191001245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191001246 D-galactonate transporter; Region: 2A0114; TIGR00893 706191001247 putative substrate translocation pore; other site 706191001248 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 706191001249 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 706191001250 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 706191001251 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315 706191001252 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 706191001253 putative ligand binding site [chemical binding]; other site 706191001254 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 706191001255 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706191001256 TM-ABC transporter signature motif; other site 706191001257 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 706191001258 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 706191001259 Walker A/P-loop; other site 706191001260 ATP binding site [chemical binding]; other site 706191001261 Q-loop/lid; other site 706191001262 ABC transporter signature motif; other site 706191001263 Walker B; other site 706191001264 D-loop; other site 706191001265 H-loop/switch region; other site 706191001266 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 706191001267 Transcriptional regulator [Transcription]; Region: IclR; COG1414 706191001268 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 706191001269 Bacterial transcriptional regulator; Region: IclR; pfam01614 706191001270 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 706191001271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191001272 Coenzyme A binding pocket [chemical binding]; other site 706191001273 AAA domain; Region: AAA_17; pfam13207 706191001274 Cupin domain; Region: Cupin_2; cl17218 706191001275 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 706191001276 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 706191001277 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 706191001278 active site 706191001279 catalytic tetrad [active] 706191001280 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 706191001281 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 706191001282 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 706191001283 conserved cys residue [active] 706191001284 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191001285 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 706191001286 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 706191001287 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 706191001288 YCII-related domain; Region: YCII; cl00999 706191001289 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 706191001290 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 706191001291 dimer interface [polypeptide binding]; other site 706191001292 ligand binding site [chemical binding]; other site 706191001293 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706191001294 dimerization interface [polypeptide binding]; other site 706191001295 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191001296 dimer interface [polypeptide binding]; other site 706191001297 putative CheW interface [polypeptide binding]; other site 706191001298 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 706191001299 DNA-binding site [nucleotide binding]; DNA binding site 706191001300 RNA-binding motif; other site 706191001301 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 706191001302 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 706191001303 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 706191001304 G1 box; other site 706191001305 GTP/Mg2+ binding site [chemical binding]; other site 706191001306 Switch I region; other site 706191001307 G2 box; other site 706191001308 G3 box; other site 706191001309 Switch II region; other site 706191001310 G4 box; other site 706191001311 G5 box; other site 706191001312 Nucleoside recognition; Region: Gate; pfam07670 706191001313 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 706191001314 Nucleoside recognition; Region: Gate; pfam07670 706191001315 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 706191001316 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 706191001317 active site 706191001318 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 706191001319 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 706191001320 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 706191001321 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 706191001322 active site 706191001323 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 706191001324 Transposase; Region: HTH_Tnp_1; cl17663 706191001325 putative transcriptional regulator; Provisional; Region: PRK11640 706191001326 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 706191001327 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 706191001328 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 706191001329 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 706191001330 DsbD alpha interface [polypeptide binding]; other site 706191001331 catalytic residues [active] 706191001332 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 706191001333 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 706191001334 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 706191001335 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 706191001336 Aspartase; Region: Aspartase; cd01357 706191001337 active sites [active] 706191001338 tetramer interface [polypeptide binding]; other site 706191001339 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 706191001340 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 706191001341 oligomerisation interface [polypeptide binding]; other site 706191001342 mobile loop; other site 706191001343 roof hairpin; other site 706191001344 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 706191001345 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 706191001346 ring oligomerisation interface [polypeptide binding]; other site 706191001347 ATP/Mg binding site [chemical binding]; other site 706191001348 stacking interactions; other site 706191001349 hinge regions; other site 706191001350 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 706191001351 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 706191001352 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706191001353 FeS/SAM binding site; other site 706191001354 elongation factor P; Validated; Region: PRK00529 706191001355 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 706191001356 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 706191001357 RNA binding site [nucleotide binding]; other site 706191001358 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 706191001359 RNA binding site [nucleotide binding]; other site 706191001360 Entericidin EcnA/B family; Region: Entericidin; pfam08085 706191001361 Predicted small secreted protein [Function unknown]; Region: COG5510 706191001362 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 706191001363 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 706191001364 poxB regulator PoxA; Provisional; Region: PRK09350 706191001365 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 706191001366 motif 1; other site 706191001367 dimer interface [polypeptide binding]; other site 706191001368 active site 706191001369 motif 2; other site 706191001370 motif 3; other site 706191001371 serine endoprotease; Provisional; Region: PRK10898 706191001372 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 706191001373 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 706191001374 protein binding site [polypeptide binding]; other site 706191001375 serine endoprotease; Provisional; Region: PRK10139 706191001376 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 706191001377 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 706191001378 protein binding site [polypeptide binding]; other site 706191001379 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 706191001380 protein binding site [polypeptide binding]; other site 706191001381 hypothetical protein; Provisional; Region: PRK11677 706191001382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 706191001383 Predicted ATPase [General function prediction only]; Region: COG1485 706191001384 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 706191001385 23S rRNA interface [nucleotide binding]; other site 706191001386 L3 interface [polypeptide binding]; other site 706191001387 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 706191001388 stringent starvation protein A; Provisional; Region: sspA; PRK09481 706191001389 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 706191001390 C-terminal domain interface [polypeptide binding]; other site 706191001391 putative GSH binding site (G-site) [chemical binding]; other site 706191001392 dimer interface [polypeptide binding]; other site 706191001393 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 706191001394 dimer interface [polypeptide binding]; other site 706191001395 N-terminal domain interface [polypeptide binding]; other site 706191001396 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 706191001397 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 706191001398 Flavodoxin; Region: Flavodoxin_1; pfam00258 706191001399 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 706191001400 FAD binding pocket [chemical binding]; other site 706191001401 FAD binding motif [chemical binding]; other site 706191001402 catalytic residues [active] 706191001403 NAD binding pocket [chemical binding]; other site 706191001404 phosphate binding motif [ion binding]; other site 706191001405 beta-alpha-beta structure motif; other site 706191001406 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 706191001407 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 706191001408 active site 706191001409 dimer interface [polypeptide binding]; other site 706191001410 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 706191001411 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 706191001412 active site 706191001413 FMN binding site [chemical binding]; other site 706191001414 substrate binding site [chemical binding]; other site 706191001415 3Fe-4S cluster binding site [ion binding]; other site 706191001416 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 706191001417 domain_subunit interface; other site 706191001418 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 706191001419 Remorin, C-terminal region; Region: Remorin_C; pfam03763 706191001420 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706191001421 putative active site [active] 706191001422 heme pocket [chemical binding]; other site 706191001423 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706191001424 dimer interface [polypeptide binding]; other site 706191001425 phosphorylation site [posttranslational modification] 706191001426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191001427 ATP binding site [chemical binding]; other site 706191001428 Mg2+ binding site [ion binding]; other site 706191001429 G-X-G motif; other site 706191001430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191001431 active site 706191001432 phosphorylation site [posttranslational modification] 706191001433 intermolecular recognition site; other site 706191001434 dimerization interface [polypeptide binding]; other site 706191001435 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 706191001436 putative binding surface; other site 706191001437 active site 706191001438 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 706191001439 Transglycosylase; Region: Transgly; cl17702 706191001440 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 706191001441 dimerization domain swap beta strand [polypeptide binding]; other site 706191001442 regulatory protein interface [polypeptide binding]; other site 706191001443 active site 706191001444 regulatory phosphorylation site [posttranslational modification]; other site 706191001445 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 706191001446 AAA domain; Region: AAA_18; pfam13238 706191001447 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 706191001448 active site 706191001449 phosphorylation site [posttranslational modification] 706191001450 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 706191001451 30S subunit binding site; other site 706191001452 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 706191001453 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 706191001454 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 706191001455 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 706191001456 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 706191001457 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 706191001458 Walker A/P-loop; other site 706191001459 ATP binding site [chemical binding]; other site 706191001460 Q-loop/lid; other site 706191001461 ABC transporter signature motif; other site 706191001462 Walker B; other site 706191001463 D-loop; other site 706191001464 H-loop/switch region; other site 706191001465 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 706191001466 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 706191001467 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 706191001468 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 706191001469 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 706191001470 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 706191001471 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 706191001472 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 706191001473 putative active site [active] 706191001474 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 706191001475 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 706191001476 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 706191001477 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 706191001478 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 706191001479 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 706191001480 Walker A/P-loop; other site 706191001481 ATP binding site [chemical binding]; other site 706191001482 Q-loop/lid; other site 706191001483 ABC transporter signature motif; other site 706191001484 Walker B; other site 706191001485 D-loop; other site 706191001486 H-loop/switch region; other site 706191001487 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 706191001488 conserved hypothetical integral membrane protein; Region: TIGR00056 706191001489 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 706191001490 mce related protein; Region: MCE; pfam02470 706191001491 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 706191001492 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 706191001493 anti sigma factor interaction site; other site 706191001494 regulatory phosphorylation site [posttranslational modification]; other site 706191001495 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 706191001496 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 706191001497 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 706191001498 hinge; other site 706191001499 active site 706191001500 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 706191001501 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 706191001502 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 706191001503 substrate binding pocket [chemical binding]; other site 706191001504 chain length determination region; other site 706191001505 substrate-Mg2+ binding site; other site 706191001506 catalytic residues [active] 706191001507 aspartate-rich region 1; other site 706191001508 active site lid residues [active] 706191001509 aspartate-rich region 2; other site 706191001510 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 706191001511 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 706191001512 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 706191001513 GTPase CgtA; Reviewed; Region: obgE; PRK12298 706191001514 GTP1/OBG; Region: GTP1_OBG; pfam01018 706191001515 Obg GTPase; Region: Obg; cd01898 706191001516 G1 box; other site 706191001517 GTP/Mg2+ binding site [chemical binding]; other site 706191001518 Switch I region; other site 706191001519 G2 box; other site 706191001520 G3 box; other site 706191001521 Switch II region; other site 706191001522 G4 box; other site 706191001523 G5 box; other site 706191001524 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 706191001525 CoenzymeA binding site [chemical binding]; other site 706191001526 subunit interaction site [polypeptide binding]; other site 706191001527 PHB binding site; other site 706191001528 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 706191001529 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 706191001530 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 706191001531 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 706191001532 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 706191001533 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 706191001534 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 706191001535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191001536 S-adenosylmethionine binding site [chemical binding]; other site 706191001537 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 706191001538 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191001539 Walker A motif; other site 706191001540 ATP binding site [chemical binding]; other site 706191001541 Walker B motif; other site 706191001542 arginine finger; other site 706191001543 Peptidase family M41; Region: Peptidase_M41; pfam01434 706191001544 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 706191001545 dihydropteroate synthase; Region: DHPS; TIGR01496 706191001546 substrate binding pocket [chemical binding]; other site 706191001547 dimer interface [polypeptide binding]; other site 706191001548 inhibitor binding site; inhibition site 706191001549 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 706191001550 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 706191001551 active site 706191001552 substrate binding site [chemical binding]; other site 706191001553 metal binding site [ion binding]; metal-binding site 706191001554 Preprotein translocase SecG subunit; Region: SecG; pfam03840 706191001555 ribosome maturation protein RimP; Reviewed; Region: PRK00092 706191001556 Sm and related proteins; Region: Sm_like; cl00259 706191001557 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 706191001558 putative oligomer interface [polypeptide binding]; other site 706191001559 putative RNA binding site [nucleotide binding]; other site 706191001560 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 706191001561 NusA N-terminal domain; Region: NusA_N; pfam08529 706191001562 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 706191001563 RNA binding site [nucleotide binding]; other site 706191001564 homodimer interface [polypeptide binding]; other site 706191001565 NusA-like KH domain; Region: KH_5; pfam13184 706191001566 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 706191001567 G-X-X-G motif; other site 706191001568 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 706191001569 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 706191001570 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 706191001571 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 706191001572 translation initiation factor IF-2; Region: IF-2; TIGR00487 706191001573 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 706191001574 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 706191001575 G1 box; other site 706191001576 putative GEF interaction site [polypeptide binding]; other site 706191001577 GTP/Mg2+ binding site [chemical binding]; other site 706191001578 Switch I region; other site 706191001579 G2 box; other site 706191001580 G3 box; other site 706191001581 Switch II region; other site 706191001582 G4 box; other site 706191001583 G5 box; other site 706191001584 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 706191001585 Translation-initiation factor 2; Region: IF-2; pfam11987 706191001586 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 706191001587 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 706191001588 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 706191001589 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 706191001590 RNA binding site [nucleotide binding]; other site 706191001591 active site 706191001592 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 706191001593 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 706191001594 16S/18S rRNA binding site [nucleotide binding]; other site 706191001595 S13e-L30e interaction site [polypeptide binding]; other site 706191001596 25S rRNA binding site [nucleotide binding]; other site 706191001597 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 706191001598 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 706191001599 RNase E interface [polypeptide binding]; other site 706191001600 trimer interface [polypeptide binding]; other site 706191001601 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 706191001602 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 706191001603 RNase E interface [polypeptide binding]; other site 706191001604 trimer interface [polypeptide binding]; other site 706191001605 active site 706191001606 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 706191001607 putative nucleic acid binding region [nucleotide binding]; other site 706191001608 G-X-X-G motif; other site 706191001609 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 706191001610 RNA binding site [nucleotide binding]; other site 706191001611 domain interface; other site 706191001612 lipoprotein NlpI; Provisional; Region: PRK11189 706191001613 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706191001614 binding surface 706191001615 TPR motif; other site 706191001616 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 706191001617 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 706191001618 ATP binding site [chemical binding]; other site 706191001619 Mg++ binding site [ion binding]; other site 706191001620 motif III; other site 706191001621 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 706191001622 nucleotide binding region [chemical binding]; other site 706191001623 ATP-binding site [chemical binding]; other site 706191001624 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 706191001625 putative RNA binding site [nucleotide binding]; other site 706191001626 hypothetical protein; Provisional; Region: PRK10508 706191001627 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 706191001628 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 706191001629 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 706191001630 putative protease; Provisional; Region: PRK15447 706191001631 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 706191001632 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 706191001633 Peptidase family U32; Region: Peptidase_U32; pfam01136 706191001634 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 706191001635 putative acetyltransferase; Provisional; Region: PRK03624 706191001636 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191001637 Coenzyme A binding pocket [chemical binding]; other site 706191001638 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 706191001639 GIY-YIG motif/motif A; other site 706191001640 putative active site [active] 706191001641 putative metal binding site [ion binding]; other site 706191001642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897 706191001643 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 706191001644 intracellular protease, PfpI family; Region: PfpI; TIGR01382 706191001645 proposed catalytic triad [active] 706191001646 conserved cys residue [active] 706191001647 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 706191001648 NADH(P)-binding; Region: NAD_binding_10; pfam13460 706191001649 NAD binding site [chemical binding]; other site 706191001650 active site 706191001651 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 706191001652 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706191001653 FeS/SAM binding site; other site 706191001654 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 706191001655 ATP cone domain; Region: ATP-cone; pfam03477 706191001656 Class III ribonucleotide reductase; Region: RNR_III; cd01675 706191001657 effector binding site; other site 706191001658 active site 706191001659 Zn binding site [ion binding]; other site 706191001660 glycine loop; other site 706191001661 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 706191001662 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 706191001663 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 706191001664 active site 706191001665 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 706191001666 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 706191001667 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191001668 DNA binding site [nucleotide binding] 706191001669 domain linker motif; other site 706191001670 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 706191001671 dimerization interface (closed form) [polypeptide binding]; other site 706191001672 ligand binding site [chemical binding]; other site 706191001673 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 706191001674 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 706191001675 molybdopterin cofactor binding site [chemical binding]; other site 706191001676 substrate binding site [chemical binding]; other site 706191001677 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 706191001678 molybdopterin cofactor binding site; other site 706191001679 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 706191001680 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 706191001681 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 706191001682 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 706191001683 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706191001684 HlyD family secretion protein; Region: HlyD_3; pfam13437 706191001685 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 706191001686 Protein export membrane protein; Region: SecD_SecF; cl14618 706191001687 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 706191001688 Protein export membrane protein; Region: SecD_SecF; cl14618 706191001689 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 706191001690 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 706191001691 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 706191001692 putative acyl-acceptor binding pocket; other site 706191001693 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 706191001694 acyl-activating enzyme (AAE) consensus motif; other site 706191001695 putative AMP binding site [chemical binding]; other site 706191001696 lysophospholipid transporter LplT; Provisional; Region: PRK11195 706191001697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191001698 putative substrate translocation pore; other site 706191001699 HAMP domain; Region: HAMP; pfam00672 706191001700 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706191001701 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191001702 dimer interface [polypeptide binding]; other site 706191001703 putative CheW interface [polypeptide binding]; other site 706191001704 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 706191001705 homotrimer interaction site [polypeptide binding]; other site 706191001706 putative active site [active] 706191001707 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 706191001708 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 706191001709 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 706191001710 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 706191001711 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 706191001712 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 706191001713 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 706191001714 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 706191001715 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 706191001716 RNase E inhibitor protein; Provisional; Region: PRK11191 706191001717 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 706191001718 active site 706191001719 dinuclear metal binding site [ion binding]; other site 706191001720 dimerization interface [polypeptide binding]; other site 706191001721 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191001722 Coenzyme A binding pocket [chemical binding]; other site 706191001723 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 706191001724 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 706191001725 HIGH motif; other site 706191001726 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 706191001727 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 706191001728 active site 706191001729 KMSKS motif; other site 706191001730 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 706191001731 tRNA binding surface [nucleotide binding]; other site 706191001732 anticodon binding site; other site 706191001733 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 706191001734 DNA polymerase III subunit chi; Validated; Region: PRK05728 706191001735 multifunctional aminopeptidase A; Provisional; Region: PRK00913 706191001736 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 706191001737 interface (dimer of trimers) [polypeptide binding]; other site 706191001738 Substrate-binding/catalytic site; other site 706191001739 Zn-binding sites [ion binding]; other site 706191001740 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 706191001741 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 706191001742 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 706191001743 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 706191001744 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 706191001745 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 706191001746 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191001747 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191001748 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 706191001749 dimerization interface [polypeptide binding]; other site 706191001750 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 706191001751 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 706191001752 trimer interface [polypeptide binding]; other site 706191001753 active site 706191001754 substrate binding site [chemical binding]; other site 706191001755 CoA binding site [chemical binding]; other site 706191001756 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 706191001757 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 706191001758 metal binding site [ion binding]; metal-binding site 706191001759 dimer interface [polypeptide binding]; other site 706191001760 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 706191001761 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 706191001762 active site 706191001763 substrate binding pocket [chemical binding]; other site 706191001764 homodimer interaction site [polypeptide binding]; other site 706191001765 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706191001766 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 706191001767 TM-ABC transporter signature motif; other site 706191001768 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 706191001769 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 706191001770 Walker A/P-loop; other site 706191001771 ATP binding site [chemical binding]; other site 706191001772 Q-loop/lid; other site 706191001773 ABC transporter signature motif; other site 706191001774 Walker B; other site 706191001775 D-loop; other site 706191001776 H-loop/switch region; other site 706191001777 Transcriptional regulators [Transcription]; Region: PurR; COG1609 706191001778 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191001779 DNA binding site [nucleotide binding] 706191001780 domain linker motif; other site 706191001781 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_11; cd06293 706191001782 putative dimerization interface [polypeptide binding]; other site 706191001783 putative ligand binding site [chemical binding]; other site 706191001784 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 706191001785 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 706191001786 ligand binding site [chemical binding]; other site 706191001787 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 706191001788 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 706191001789 substrate binding site [chemical binding]; other site 706191001790 dimer interface [polypeptide binding]; other site 706191001791 ATP binding site [chemical binding]; other site 706191001792 BtpA family; Region: BtpA; cl00440 706191001793 Predicted membrane protein [Function unknown]; Region: COG2733 706191001794 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 706191001795 Zonular occludens toxin (Zot); Region: Zot; cl17485 706191001796 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 706191001797 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 706191001798 inner membrane protein; Provisional; Region: PRK10995 706191001799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706191001800 hypothetical protein; Provisional; Region: PRK11667 706191001801 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 706191001802 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 706191001803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 706191001804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191001805 ATP binding site [chemical binding]; other site 706191001806 Mg2+ binding site [ion binding]; other site 706191001807 G-X-G motif; other site 706191001808 Phosphotransferase enzyme family; Region: APH; pfam01636 706191001809 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 706191001810 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 706191001811 Methyltransferase domain; Region: Methyltransf_31; pfam13847 706191001812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191001813 S-adenosylmethionine binding site [chemical binding]; other site 706191001814 hypothetical protein; Provisional; Region: PRK07206 706191001815 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 706191001816 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 706191001817 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 706191001818 Helix-turn-helix domain; Region: HTH_18; pfam12833 706191001819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191001820 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 706191001821 H+ Antiporter protein; Region: 2A0121; TIGR00900 706191001822 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 706191001823 catalytic core [active] 706191001824 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 706191001825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191001826 D-galactonate transporter; Region: 2A0114; TIGR00893 706191001827 putative substrate translocation pore; other site 706191001828 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 706191001829 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 706191001830 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 706191001831 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 706191001832 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 706191001833 substrate binding site [chemical binding]; other site 706191001834 dimer interface [polypeptide binding]; other site 706191001835 ATP binding site [chemical binding]; other site 706191001836 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 706191001837 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 706191001838 active site 706191001839 inhibitor site; inhibition site 706191001840 dimer interface [polypeptide binding]; other site 706191001841 catalytic residue [active] 706191001842 Domain of unknown function (DUF386); Region: DUF386; cl01047 706191001843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191001844 D-galactonate transporter; Region: 2A0114; TIGR00893 706191001845 putative substrate translocation pore; other site 706191001846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 706191001847 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 706191001848 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 706191001849 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 706191001850 putative acyl-acceptor binding pocket; other site 706191001851 Phosphopantetheine attachment site; Region: PP-binding; cl09936 706191001852 acyl carrier protein; Provisional; Region: PRK05350 706191001853 Predicted membrane protein [Function unknown]; Region: COG4648 706191001854 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 706191001855 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706191001856 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706191001857 acyl-activating enzyme (AAE) consensus motif; other site 706191001858 acyl-activating enzyme (AAE) consensus motif; other site 706191001859 AMP binding site [chemical binding]; other site 706191001860 active site 706191001861 CoA binding site [chemical binding]; other site 706191001862 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 706191001863 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 706191001864 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 706191001865 Ligand binding site; other site 706191001866 Putative Catalytic site; other site 706191001867 DXD motif; other site 706191001868 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 706191001869 putative acyl-acceptor binding pocket; other site 706191001870 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 706191001871 active site 706191001872 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 706191001873 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 706191001874 Predicted exporter [General function prediction only]; Region: COG4258 706191001875 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 706191001876 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 706191001877 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 706191001878 dimer interface [polypeptide binding]; other site 706191001879 active site 706191001880 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 706191001881 putative active site 1 [active] 706191001882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706191001883 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 706191001884 NAD(P) binding site [chemical binding]; other site 706191001885 active site 706191001886 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 706191001887 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 706191001888 dimer interface [polypeptide binding]; other site 706191001889 active site 706191001890 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 706191001891 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 706191001892 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 706191001893 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 706191001894 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 706191001895 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 706191001896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191001897 Coenzyme A binding pocket [chemical binding]; other site 706191001898 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 706191001899 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 706191001900 glycerate dehydrogenase; Provisional; Region: PRK06487 706191001901 putative ligand binding site [chemical binding]; other site 706191001902 putative NAD binding site [chemical binding]; other site 706191001903 catalytic site [active] 706191001904 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 706191001905 putative active site; other site 706191001906 catalytic residue [active] 706191001907 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 706191001908 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 706191001909 putative NAD(P) binding site [chemical binding]; other site 706191001910 catalytic Zn binding site [ion binding]; other site 706191001911 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 706191001912 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 706191001913 nucleotide binding site [chemical binding]; other site 706191001914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191001915 D-galactonate transporter; Region: 2A0114; TIGR00893 706191001916 putative substrate translocation pore; other site 706191001917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191001918 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 706191001919 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 706191001920 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191001921 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 706191001922 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 706191001923 active site 706191001924 substrate binding site [chemical binding]; other site 706191001925 ATP binding site [chemical binding]; other site 706191001926 ethanolamine permease; Region: 2A0305; TIGR00908 706191001927 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 706191001928 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 706191001929 inhibitor-cofactor binding pocket; inhibition site 706191001930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191001931 catalytic residue [active] 706191001932 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 706191001933 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 706191001934 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 706191001935 NADP binding site [chemical binding]; other site 706191001936 homodimer interface [polypeptide binding]; other site 706191001937 active site 706191001938 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 706191001939 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 706191001940 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 706191001941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191001942 dimer interface [polypeptide binding]; other site 706191001943 conserved gate region; other site 706191001944 putative PBP binding loops; other site 706191001945 ABC-ATPase subunit interface; other site 706191001946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191001947 dimer interface [polypeptide binding]; other site 706191001948 conserved gate region; other site 706191001949 putative PBP binding loops; other site 706191001950 ABC-ATPase subunit interface; other site 706191001951 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 706191001952 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 706191001953 Walker A/P-loop; other site 706191001954 ATP binding site [chemical binding]; other site 706191001955 Q-loop/lid; other site 706191001956 ABC transporter signature motif; other site 706191001957 Walker B; other site 706191001958 D-loop; other site 706191001959 H-loop/switch region; other site 706191001960 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 706191001961 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 706191001962 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 706191001963 metal binding site [ion binding]; metal-binding site 706191001964 substrate binding pocket [chemical binding]; other site 706191001965 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 706191001966 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 706191001967 NADP binding site [chemical binding]; other site 706191001968 homodimer interface [polypeptide binding]; other site 706191001969 active site 706191001970 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 706191001971 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 706191001972 putative NAD(P) binding site [chemical binding]; other site 706191001973 catalytic Zn binding site [ion binding]; other site 706191001974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191001975 metabolite-proton symporter; Region: 2A0106; TIGR00883 706191001976 putative substrate translocation pore; other site 706191001977 Transcriptional regulators [Transcription]; Region: FadR; COG2186 706191001978 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191001979 DNA-binding site [nucleotide binding]; DNA binding site 706191001980 FCD domain; Region: FCD; pfam07729 706191001981 hypothetical protein; Provisional; Region: PRK10396 706191001982 yecA family protein; Region: ygfB_yecA; TIGR02292 706191001983 SEC-C motif; Region: SEC-C; pfam02810 706191001984 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 706191001985 Beta-lactamase; Region: Beta-lactamase; pfam00144 706191001986 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 706191001987 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 706191001988 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 706191001989 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 706191001990 phosphoglycerol transferase I; Provisional; Region: PRK03776 706191001991 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 706191001992 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 706191001993 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 706191001994 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 706191001995 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 706191001996 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 706191001997 catalytic core [active] 706191001998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191001999 metabolite-proton symporter; Region: 2A0106; TIGR00883 706191002000 putative substrate translocation pore; other site 706191002001 Transcriptional regulators [Transcription]; Region: PurR; COG1609 706191002002 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191002003 DNA binding site [nucleotide binding] 706191002004 domain linker motif; other site 706191002005 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 706191002006 dimerization interface [polypeptide binding]; other site 706191002007 ligand binding site [chemical binding]; other site 706191002008 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 706191002009 active site 706191002010 putative sialic acid transporter; Region: 2A0112; TIGR00891 706191002011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191002012 putative substrate translocation pore; other site 706191002013 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 706191002014 putative deacylase active site [active] 706191002015 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 706191002016 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706191002017 metal binding site [ion binding]; metal-binding site 706191002018 active site 706191002019 I-site; other site 706191002020 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 706191002021 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 706191002022 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 706191002023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191002024 S-adenosylmethionine binding site [chemical binding]; other site 706191002025 DNA polymerase III subunit psi; Validated; Region: PRK06856 706191002026 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 706191002027 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191002028 Coenzyme A binding pocket [chemical binding]; other site 706191002029 dUMP phosphatase; Provisional; Region: PRK09449 706191002030 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191002031 motif II; other site 706191002032 hypothetical protein; Provisional; Region: PRK11246 706191002033 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 706191002034 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191002035 motif II; other site 706191002036 DNA repair protein RadA; Region: sms; TIGR00416 706191002037 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 706191002038 Walker A motif/ATP binding site; other site 706191002039 ATP binding site [chemical binding]; other site 706191002040 Walker B motif; other site 706191002041 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 706191002042 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706191002043 non-specific DNA binding site [nucleotide binding]; other site 706191002044 salt bridge; other site 706191002045 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 706191002046 sequence-specific DNA binding site [nucleotide binding]; other site 706191002047 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 706191002048 active site 706191002049 (T/H)XGH motif; other site 706191002050 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 706191002051 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 706191002052 DNA binding site [nucleotide binding] 706191002053 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 706191002054 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 706191002055 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 706191002056 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 706191002057 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 706191002058 PapC N-terminal domain; Region: PapC_N; pfam13954 706191002059 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 706191002060 PapC C-terminal domain; Region: PapC_C; pfam13953 706191002061 Fimbrial protein; Region: Fimbrial; cl01416 706191002062 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 706191002063 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 706191002064 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 706191002065 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 706191002066 putative NAD(P) binding site [chemical binding]; other site 706191002067 dimer interface [polypeptide binding]; other site 706191002068 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191002069 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191002070 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 706191002071 putative effector binding pocket; other site 706191002072 dimerization interface [polypeptide binding]; other site 706191002073 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 706191002074 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 706191002075 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 706191002076 ABC transporter; Region: ABC_tran_2; pfam12848 706191002077 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 706191002078 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 706191002079 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 706191002080 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 706191002081 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 706191002082 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 706191002083 substrate binding site [chemical binding]; other site 706191002084 dimer interface [polypeptide binding]; other site 706191002085 ATP binding site [chemical binding]; other site 706191002086 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 706191002087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191002088 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 706191002089 active site 706191002090 catalytic residues [active] 706191002091 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 706191002092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191002093 catalytic residue [active] 706191002094 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 706191002095 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706191002096 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 706191002097 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 706191002098 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 706191002099 IucA / IucC family; Region: IucA_IucC; pfam04183 706191002100 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 706191002101 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 706191002102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191002103 putative substrate translocation pore; other site 706191002104 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 706191002105 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 706191002106 N-terminal plug; other site 706191002107 ligand-binding site [chemical binding]; other site 706191002108 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 706191002109 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 706191002110 Walker A/P-loop; other site 706191002111 ATP binding site [chemical binding]; other site 706191002112 Q-loop/lid; other site 706191002113 ABC transporter signature motif; other site 706191002114 Walker B; other site 706191002115 D-loop; other site 706191002116 H-loop/switch region; other site 706191002117 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 706191002118 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 706191002119 Walker A/P-loop; other site 706191002120 ATP binding site [chemical binding]; other site 706191002121 Q-loop/lid; other site 706191002122 ABC transporter signature motif; other site 706191002123 Walker B; other site 706191002124 D-loop; other site 706191002125 H-loop/switch region; other site 706191002126 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 706191002127 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 706191002128 TM-ABC transporter signature motif; other site 706191002129 HEAT repeats; Region: HEAT_2; pfam13646 706191002130 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 706191002131 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706191002132 TM-ABC transporter signature motif; other site 706191002133 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 706191002134 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 706191002135 putative ligand binding site [chemical binding]; other site 706191002136 Transcriptional regulators [Transcription]; Region: GntR; COG1802 706191002137 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191002138 DNA-binding site [nucleotide binding]; DNA binding site 706191002139 FCD domain; Region: FCD; pfam07729 706191002140 allophanate hydrolase; Provisional; Region: PRK08186 706191002141 Amidase; Region: Amidase; cl11426 706191002142 urea carboxylase; Region: urea_carbox; TIGR02712 706191002143 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 706191002144 ATP-grasp domain; Region: ATP-grasp_4; cl17255 706191002145 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 706191002146 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 706191002147 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 706191002148 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 706191002149 carboxyltransferase (CT) interaction site; other site 706191002150 biotinylation site [posttranslational modification]; other site 706191002151 lytic murein transglycosylase; Provisional; Region: PRK11619 706191002152 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 706191002153 N-acetyl-D-glucosamine binding site [chemical binding]; other site 706191002154 catalytic residue [active] 706191002155 Trp operon repressor; Provisional; Region: PRK01381 706191002156 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 706191002157 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 706191002158 catalytic core [active] 706191002159 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 706191002160 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191002161 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 706191002162 hypothetical protein; Provisional; Region: PRK10756 706191002163 CreA protein; Region: CreA; pfam05981 706191002164 two-component response regulator; Provisional; Region: PRK11173 706191002165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191002166 active site 706191002167 phosphorylation site [posttranslational modification] 706191002168 intermolecular recognition site; other site 706191002169 dimerization interface [polypeptide binding]; other site 706191002170 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706191002171 DNA binding site [nucleotide binding] 706191002172 putative RNA methyltransferase; Provisional; Region: PRK10433 706191002173 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 706191002174 Threonine operon leader; PANA_ncRNA24 706191002175 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 706191002176 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 706191002177 putative catalytic residues [active] 706191002178 putative nucleotide binding site [chemical binding]; other site 706191002179 putative aspartate binding site [chemical binding]; other site 706191002180 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 706191002181 dimer interface [polypeptide binding]; other site 706191002182 putative threonine allosteric regulatory site; other site 706191002183 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 706191002184 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 706191002185 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 706191002186 homoserine kinase; Provisional; Region: PRK01212 706191002187 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 706191002188 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 706191002189 threonine synthase; Validated; Region: PRK09225 706191002190 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 706191002191 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 706191002192 catalytic residue [active] 706191002193 hypothetical protein; Validated; Region: PRK02101 706191002194 transaldolase-like protein; Provisional; Region: PTZ00411 706191002195 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 706191002196 active site 706191002197 dimer interface [polypeptide binding]; other site 706191002198 catalytic residue [active] 706191002199 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 706191002200 MPT binding site; other site 706191002201 trimer interface [polypeptide binding]; other site 706191002202 metabolite-proton symporter; Region: 2A0106; TIGR00883 706191002203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191002204 putative substrate translocation pore; other site 706191002205 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 706191002206 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 706191002207 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 706191002208 nucleotide binding site [chemical binding]; other site 706191002209 chaperone protein DnaJ; Provisional; Region: PRK10767 706191002210 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 706191002211 HSP70 interaction site [polypeptide binding]; other site 706191002212 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 706191002213 substrate binding site [polypeptide binding]; other site 706191002214 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 706191002215 Zn binding sites [ion binding]; other site 706191002216 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 706191002217 dimer interface [polypeptide binding]; other site 706191002218 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 706191002219 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 706191002220 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 706191002221 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 706191002222 active site 706191002223 Riboflavin kinase; Region: Flavokinase; smart00904 706191002224 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 706191002225 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 706191002226 active site 706191002227 HIGH motif; other site 706191002228 nucleotide binding site [chemical binding]; other site 706191002229 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 706191002230 active site 706191002231 KMSKS motif; other site 706191002232 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 706191002233 tRNA binding surface [nucleotide binding]; other site 706191002234 anticodon binding site; other site 706191002235 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 706191002236 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 706191002237 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 706191002238 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 706191002239 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 706191002240 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 706191002241 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 706191002242 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 706191002243 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 706191002244 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 706191002245 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 706191002246 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 706191002247 catalytic site [active] 706191002248 subunit interface [polypeptide binding]; other site 706191002249 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 706191002250 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 706191002251 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 706191002252 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 706191002253 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 706191002254 ATP-grasp domain; Region: ATP-grasp_4; cl17255 706191002255 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 706191002256 IMP binding site; other site 706191002257 dimer interface [polypeptide binding]; other site 706191002258 interdomain contacts; other site 706191002259 partial ornithine binding site; other site 706191002260 Mig-14; Region: Mig-14; pfam07395 706191002261 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 706191002262 NAD(P) binding site [chemical binding]; other site 706191002263 active site 706191002264 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191002265 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191002266 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 706191002267 dimerization interface [polypeptide binding]; other site 706191002268 putative effector binding pocket; other site 706191002269 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 706191002270 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 706191002271 eyelet of channel; other site 706191002272 trimer interface [polypeptide binding]; other site 706191002273 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 706191002274 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 706191002275 folate binding site [chemical binding]; other site 706191002276 NADP+ binding site [chemical binding]; other site 706191002277 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 706191002278 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 706191002279 active site 706191002280 metal binding site [ion binding]; metal-binding site 706191002281 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 706191002282 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 706191002283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191002284 S-adenosylmethionine binding site [chemical binding]; other site 706191002285 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 706191002286 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 706191002287 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 706191002288 SurA N-terminal domain; Region: SurA_N; pfam09312 706191002289 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 706191002290 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 706191002291 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 706191002292 OstA-like protein; Region: OstA; pfam03968 706191002293 Organic solvent tolerance protein; Region: OstA_C; pfam04453 706191002294 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 706191002295 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 706191002296 putative metal binding site [ion binding]; other site 706191002297 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 706191002298 HSP70 interaction site [polypeptide binding]; other site 706191002299 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 706191002300 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 706191002301 active site 706191002302 ATP-dependent helicase HepA; Validated; Region: PRK04914 706191002303 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 706191002304 ATP binding site [chemical binding]; other site 706191002305 putative Mg++ binding site [ion binding]; other site 706191002306 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 706191002307 nucleotide binding region [chemical binding]; other site 706191002308 ATP-binding site [chemical binding]; other site 706191002309 DNA polymerase II; Reviewed; Region: PRK05762 706191002310 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 706191002311 active site 706191002312 catalytic site [active] 706191002313 substrate binding site [chemical binding]; other site 706191002314 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 706191002315 active site 706191002316 metal-binding site 706191002317 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 706191002318 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 706191002319 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 706191002320 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 706191002321 Walker A/P-loop; other site 706191002322 ATP binding site [chemical binding]; other site 706191002323 Q-loop/lid; other site 706191002324 ABC transporter signature motif; other site 706191002325 Walker B; other site 706191002326 D-loop; other site 706191002327 H-loop/switch region; other site 706191002328 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 706191002329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191002330 dimer interface [polypeptide binding]; other site 706191002331 conserved gate region; other site 706191002332 putative PBP binding loops; other site 706191002333 ABC-ATPase subunit interface; other site 706191002334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191002335 dimer interface [polypeptide binding]; other site 706191002336 conserved gate region; other site 706191002337 putative PBP binding loops; other site 706191002338 ABC-ATPase subunit interface; other site 706191002339 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 706191002340 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 706191002341 transcriptional regulator SgrR; Provisional; Region: PRK13626 706191002342 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 706191002343 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 706191002344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191002345 sugar efflux transporter; Region: 2A0120; TIGR00899 706191002346 putative substrate translocation pore; other site 706191002347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191002348 D-galactonate transporter; Region: 2A0114; TIGR00893 706191002349 putative substrate translocation pore; other site 706191002350 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191002351 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191002352 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 706191002353 putative dimerization interface [polypeptide binding]; other site 706191002354 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 706191002355 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 706191002356 active site 706191002357 catalytic residue [active] 706191002358 dimer interface [polypeptide binding]; other site 706191002359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191002360 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706191002361 putative substrate translocation pore; other site 706191002362 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 706191002363 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 706191002364 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 706191002365 shikimate binding site; other site 706191002366 NAD(P) binding site [chemical binding]; other site 706191002367 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 706191002368 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 706191002369 active site 706191002370 FMN binding site [chemical binding]; other site 706191002371 substrate binding site [chemical binding]; other site 706191002372 putative catalytic residue [active] 706191002373 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 706191002374 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706191002375 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 706191002376 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 706191002377 substrate binding site [chemical binding]; other site 706191002378 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 706191002379 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 706191002380 substrate binding site [chemical binding]; other site 706191002381 ligand binding site [chemical binding]; other site 706191002382 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 706191002383 tartrate dehydrogenase; Provisional; Region: PRK08194 706191002384 2-isopropylmalate synthase; Validated; Region: PRK00915 706191002385 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 706191002386 active site 706191002387 catalytic residues [active] 706191002388 metal binding site [ion binding]; metal-binding site 706191002389 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 706191002390 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 706191002391 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 706191002392 PYR/PP interface [polypeptide binding]; other site 706191002393 dimer interface [polypeptide binding]; other site 706191002394 TPP binding site [chemical binding]; other site 706191002395 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 706191002396 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 706191002397 TPP-binding site [chemical binding]; other site 706191002398 dimer interface [polypeptide binding]; other site 706191002399 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 706191002400 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 706191002401 putative valine binding site [chemical binding]; other site 706191002402 dimer interface [polypeptide binding]; other site 706191002403 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 706191002404 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 706191002405 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191002406 DNA binding site [nucleotide binding] 706191002407 domain linker motif; other site 706191002408 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 706191002409 dimerization interface [polypeptide binding]; other site 706191002410 ligand binding site [chemical binding]; other site 706191002411 cell division protein MraZ; Reviewed; Region: PRK00326 706191002412 MraZ protein; Region: MraZ; pfam02381 706191002413 MraZ protein; Region: MraZ; pfam02381 706191002414 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 706191002415 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 706191002416 cell division protein FtsL; Provisional; Region: PRK10772 706191002417 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 706191002418 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 706191002419 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 706191002420 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 706191002421 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 706191002422 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 706191002423 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 706191002424 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 706191002425 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 706191002426 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 706191002427 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 706191002428 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 706191002429 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 706191002430 Mg++ binding site [ion binding]; other site 706191002431 putative catalytic motif [active] 706191002432 putative substrate binding site [chemical binding]; other site 706191002433 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 706191002434 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 706191002435 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 706191002436 cell division protein FtsW; Provisional; Region: PRK10774 706191002437 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 706191002438 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 706191002439 active site 706191002440 homodimer interface [polypeptide binding]; other site 706191002441 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 706191002442 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 706191002443 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 706191002444 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 706191002445 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 706191002446 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 706191002447 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 706191002448 cell division protein FtsQ; Provisional; Region: PRK10775 706191002449 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 706191002450 Cell division protein FtsQ; Region: FtsQ; pfam03799 706191002451 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 706191002452 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 706191002453 Cell division protein FtsA; Region: FtsA; pfam14450 706191002454 cell division protein FtsZ; Validated; Region: PRK09330 706191002455 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 706191002456 nucleotide binding site [chemical binding]; other site 706191002457 SulA interaction site; other site 706191002458 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 706191002459 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 706191002460 SecA regulator SecM; Provisional; Region: PRK02943 706191002461 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 706191002462 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 706191002463 SEC-C motif; Region: SEC-C; pfam02810 706191002464 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 706191002465 active site 706191002466 8-oxo-dGMP binding site [chemical binding]; other site 706191002467 nudix motif; other site 706191002468 metal binding site [ion binding]; metal-binding site 706191002469 Domain of unknown function (DUF329); Region: DUF329; cl01144 706191002470 hypothetical protein; Provisional; Region: PRK05287 706191002471 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 706191002472 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 706191002473 CoA-binding site [chemical binding]; other site 706191002474 ATP-binding [chemical binding]; other site 706191002475 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 706191002476 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 706191002477 active site 706191002478 type IV pilin biogenesis protein; Provisional; Region: PRK10573 706191002479 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 706191002480 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 706191002481 hypothetical protein; Provisional; Region: PRK10436 706191002482 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 706191002483 Walker A motif; other site 706191002484 ATP binding site [chemical binding]; other site 706191002485 Walker B motif; other site 706191002486 putative major pilin subunit; Provisional; Region: PRK10574 706191002487 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 706191002488 Pilin (bacterial filament); Region: Pilin; pfam00114 706191002489 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 706191002490 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 706191002491 dimerization interface [polypeptide binding]; other site 706191002492 active site 706191002493 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 706191002494 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 706191002495 amidase catalytic site [active] 706191002496 substrate binding site [chemical binding]; other site 706191002497 Zn binding residues [ion binding]; other site 706191002498 regulatory protein AmpE; Provisional; Region: PRK10987 706191002499 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 706191002500 active site 706191002501 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 706191002502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191002503 putative substrate translocation pore; other site 706191002504 Amino acid permease; Region: AA_permease; pfam00324 706191002505 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 706191002506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191002507 DNA-binding site [nucleotide binding]; DNA binding site 706191002508 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 706191002509 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 706191002510 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 706191002511 dimer interface [polypeptide binding]; other site 706191002512 TPP-binding site [chemical binding]; other site 706191002513 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 706191002514 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 706191002515 E3 interaction surface; other site 706191002516 lipoyl attachment site [posttranslational modification]; other site 706191002517 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 706191002518 E3 interaction surface; other site 706191002519 lipoyl attachment site [posttranslational modification]; other site 706191002520 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 706191002521 E3 interaction surface; other site 706191002522 lipoyl attachment site [posttranslational modification]; other site 706191002523 e3 binding domain; Region: E3_binding; pfam02817 706191002524 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 706191002525 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 706191002526 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706191002527 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706191002528 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 706191002529 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191002530 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191002531 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 706191002532 putative effector binding pocket; other site 706191002533 putative dimerization interface [polypeptide binding]; other site 706191002534 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 706191002535 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 706191002536 active site 706191002537 catalytic tetrad [active] 706191002538 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 706191002539 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 706191002540 substrate binding site [chemical binding]; other site 706191002541 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 706191002542 substrate binding site [chemical binding]; other site 706191002543 ligand binding site [chemical binding]; other site 706191002544 hypothetical protein; Provisional; Region: PRK05248 706191002545 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 706191002546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 706191002547 CHASE3 domain; Region: CHASE3; pfam05227 706191002548 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 706191002549 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706191002550 dimerization interface [polypeptide binding]; other site 706191002551 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191002552 dimer interface [polypeptide binding]; other site 706191002553 putative CheW interface [polypeptide binding]; other site 706191002554 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 706191002555 active site 706191002556 TDP-binding site; other site 706191002557 acceptor substrate-binding pocket; other site 706191002558 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 706191002559 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 706191002560 spermidine synthase; Provisional; Region: PRK00811 706191002561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191002562 S-adenosylmethionine binding site [chemical binding]; other site 706191002563 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 706191002564 multicopper oxidase; Provisional; Region: PRK10965 706191002565 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 706191002566 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 706191002567 methionine gamma-lyase; Validated; Region: PRK07049 706191002568 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 706191002569 homodimer interface [polypeptide binding]; other site 706191002570 substrate-cofactor binding pocket; other site 706191002571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191002572 catalytic residue [active] 706191002573 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 706191002574 active site 706191002575 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 706191002576 active site clefts [active] 706191002577 zinc binding site [ion binding]; other site 706191002578 dimer interface [polypeptide binding]; other site 706191002579 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 706191002580 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 706191002581 Walker A/P-loop; other site 706191002582 ATP binding site [chemical binding]; other site 706191002583 Q-loop/lid; other site 706191002584 ABC transporter signature motif; other site 706191002585 Walker B; other site 706191002586 D-loop; other site 706191002587 H-loop/switch region; other site 706191002588 inner membrane transport permease; Provisional; Region: PRK15066 706191002589 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 706191002590 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 706191002591 tetramerization interface [polypeptide binding]; other site 706191002592 active site 706191002593 Pantoate-beta-alanine ligase; Region: PanC; cd00560 706191002594 pantoate--beta-alanine ligase; Region: panC; TIGR00018 706191002595 active site 706191002596 ATP-binding site [chemical binding]; other site 706191002597 pantoate-binding site; other site 706191002598 HXXH motif; other site 706191002599 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 706191002600 oligomerization interface [polypeptide binding]; other site 706191002601 active site 706191002602 metal binding site [ion binding]; metal-binding site 706191002603 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 706191002604 catalytic center binding site [active] 706191002605 ATP binding site [chemical binding]; other site 706191002606 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 706191002607 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 706191002608 active site 706191002609 NTP binding site [chemical binding]; other site 706191002610 metal binding triad [ion binding]; metal-binding site 706191002611 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 706191002612 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 706191002613 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 706191002614 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 706191002615 active site 706191002616 nucleotide binding site [chemical binding]; other site 706191002617 HIGH motif; other site 706191002618 KMSKS motif; other site 706191002619 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 706191002620 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 706191002621 2'-5' RNA ligase; Provisional; Region: PRK15124 706191002622 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 706191002623 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 706191002624 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 706191002625 ATP binding site [chemical binding]; other site 706191002626 putative Mg++ binding site [ion binding]; other site 706191002627 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 706191002628 nucleotide binding region [chemical binding]; other site 706191002629 ATP-binding site [chemical binding]; other site 706191002630 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 706191002631 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 706191002632 Transglycosylase; Region: Transgly; pfam00912 706191002633 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 706191002634 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 706191002635 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 706191002636 N-terminal plug; other site 706191002637 ligand-binding site [chemical binding]; other site 706191002638 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 706191002639 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 706191002640 Walker A/P-loop; other site 706191002641 ATP binding site [chemical binding]; other site 706191002642 Q-loop/lid; other site 706191002643 ABC transporter signature motif; other site 706191002644 Walker B; other site 706191002645 D-loop; other site 706191002646 H-loop/switch region; other site 706191002647 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 706191002648 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 706191002649 siderophore binding site; other site 706191002650 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 706191002651 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 706191002652 ABC-ATPase subunit interface; other site 706191002653 dimer interface [polypeptide binding]; other site 706191002654 putative PBP binding regions; other site 706191002655 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 706191002656 ABC-ATPase subunit interface; other site 706191002657 dimer interface [polypeptide binding]; other site 706191002658 putative PBP binding regions; other site 706191002659 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 706191002660 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 706191002661 inhibitor-cofactor binding pocket; inhibition site 706191002662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191002663 catalytic residue [active] 706191002664 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 706191002665 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 706191002666 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 706191002667 cobalamin binding residues [chemical binding]; other site 706191002668 putative BtuC binding residues; other site 706191002669 dimer interface [polypeptide binding]; other site 706191002670 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 706191002671 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 706191002672 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 706191002673 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706191002674 Zn2+ binding site [ion binding]; other site 706191002675 Mg2+ binding site [ion binding]; other site 706191002676 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 706191002677 serine endoprotease; Provisional; Region: PRK10942 706191002678 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 706191002679 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 706191002680 protein binding site [polypeptide binding]; other site 706191002681 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 706191002682 protein binding site [polypeptide binding]; other site 706191002683 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 706191002684 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 706191002685 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 706191002686 Alginate lyase; Region: Alginate_lyase; pfam05426 706191002687 hypothetical protein; Provisional; Region: PRK13677 706191002688 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 706191002689 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 706191002690 trimer interface [polypeptide binding]; other site 706191002691 active site 706191002692 substrate binding site [chemical binding]; other site 706191002693 CoA binding site [chemical binding]; other site 706191002694 PII uridylyl-transferase; Provisional; Region: PRK05007 706191002695 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 706191002696 metal binding triad; other site 706191002697 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 706191002698 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706191002699 Zn2+ binding site [ion binding]; other site 706191002700 Mg2+ binding site [ion binding]; other site 706191002701 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 706191002702 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 706191002703 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 706191002704 active site 706191002705 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 706191002706 rRNA interaction site [nucleotide binding]; other site 706191002707 S8 interaction site; other site 706191002708 putative laminin-1 binding site; other site 706191002709 elongation factor Ts; Provisional; Region: tsf; PRK09377 706191002710 UBA/TS-N domain; Region: UBA; pfam00627 706191002711 Elongation factor TS; Region: EF_TS; pfam00889 706191002712 Elongation factor TS; Region: EF_TS; pfam00889 706191002713 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 706191002714 putative nucleotide binding site [chemical binding]; other site 706191002715 uridine monophosphate binding site [chemical binding]; other site 706191002716 homohexameric interface [polypeptide binding]; other site 706191002717 ribosome recycling factor; Reviewed; Region: frr; PRK00083 706191002718 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 706191002719 hinge region; other site 706191002720 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 706191002721 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 706191002722 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 706191002723 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 706191002724 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 706191002725 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 706191002726 catalytic residue [active] 706191002727 putative FPP diphosphate binding site; other site 706191002728 putative FPP binding hydrophobic cleft; other site 706191002729 dimer interface [polypeptide binding]; other site 706191002730 putative IPP diphosphate binding site; other site 706191002731 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 706191002732 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 706191002733 zinc metallopeptidase RseP; Provisional; Region: PRK10779 706191002734 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 706191002735 active site 706191002736 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 706191002737 protein binding site [polypeptide binding]; other site 706191002738 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 706191002739 protein binding site [polypeptide binding]; other site 706191002740 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 706191002741 putative substrate binding region [chemical binding]; other site 706191002742 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 706191002743 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 706191002744 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 706191002745 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 706191002746 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 706191002747 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 706191002748 Surface antigen; Region: Bac_surface_Ag; pfam01103 706191002749 periplasmic chaperone; Provisional; Region: PRK10780 706191002750 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 706191002751 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 706191002752 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 706191002753 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 706191002754 trimer interface [polypeptide binding]; other site 706191002755 active site 706191002756 UDP-GlcNAc binding site [chemical binding]; other site 706191002757 lipid binding site [chemical binding]; lipid-binding site 706191002758 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 706191002759 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 706191002760 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 706191002761 active site 706191002762 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 706191002763 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 706191002764 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 706191002765 RNA/DNA hybrid binding site [nucleotide binding]; other site 706191002766 active site 706191002767 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 706191002768 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 706191002769 putative active site [active] 706191002770 putative PHP Thumb interface [polypeptide binding]; other site 706191002771 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 706191002772 generic binding surface II; other site 706191002773 generic binding surface I; other site 706191002774 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 706191002775 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 706191002776 lysine decarboxylase LdcC; Provisional; Region: PRK15399 706191002777 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 706191002778 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 706191002779 homodimer interface [polypeptide binding]; other site 706191002780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191002781 catalytic residue [active] 706191002782 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 706191002783 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 706191002784 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 706191002785 putative metal binding site [ion binding]; other site 706191002786 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 706191002787 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 706191002788 Ligand Binding Site [chemical binding]; other site 706191002789 TilS substrate binding domain; Region: TilS; pfam09179 706191002790 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 706191002791 Cytochrome c; Region: Cytochrom_C; cl11414 706191002792 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 706191002793 hypothetical protein; Provisional; Region: PRK04964 706191002794 hypothetical protein; Provisional; Region: PRK09256 706191002795 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 706191002796 prolyl-tRNA synthetase; Provisional; Region: PRK09194 706191002797 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 706191002798 dimer interface [polypeptide binding]; other site 706191002799 motif 1; other site 706191002800 active site 706191002801 motif 2; other site 706191002802 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 706191002803 putative deacylase active site [active] 706191002804 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 706191002805 active site 706191002806 motif 3; other site 706191002807 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 706191002808 anticodon binding site; other site 706191002809 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 706191002810 homodimer interaction site [polypeptide binding]; other site 706191002811 cofactor binding site; other site 706191002812 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 706191002813 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 706191002814 lipoprotein, YaeC family; Region: TIGR00363 706191002815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191002816 dimer interface [polypeptide binding]; other site 706191002817 conserved gate region; other site 706191002818 ABC-ATPase subunit interface; other site 706191002819 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 706191002820 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 706191002821 Walker A/P-loop; other site 706191002822 ATP binding site [chemical binding]; other site 706191002823 Q-loop/lid; other site 706191002824 ABC transporter signature motif; other site 706191002825 Walker B; other site 706191002826 D-loop; other site 706191002827 H-loop/switch region; other site 706191002828 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 706191002829 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191002830 motif II; other site 706191002831 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191002832 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 706191002833 dimerization interface [polypeptide binding]; other site 706191002834 hypothetical protein; Provisional; Region: PRK05421 706191002835 putative catalytic site [active] 706191002836 putative metal binding site [ion binding]; other site 706191002837 putative phosphate binding site [ion binding]; other site 706191002838 putative catalytic site [active] 706191002839 putative phosphate binding site [ion binding]; other site 706191002840 putative metal binding site [ion binding]; other site 706191002841 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 706191002842 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 706191002843 N-acetyl-D-glucosamine binding site [chemical binding]; other site 706191002844 catalytic residue [active] 706191002845 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 706191002846 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 706191002847 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 706191002848 Methyltransferase domain; Region: Methyltransf_11; pfam08241 706191002849 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 706191002850 RNA/DNA hybrid binding site [nucleotide binding]; other site 706191002851 active site 706191002852 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 706191002853 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 706191002854 active site 706191002855 catalytic site [active] 706191002856 substrate binding site [chemical binding]; other site 706191002857 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 706191002858 active site 706191002859 intersubunit interactions; other site 706191002860 catalytic residue [active] 706191002861 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 706191002862 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 706191002863 putative active site [active] 706191002864 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 706191002865 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 706191002866 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 706191002867 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 706191002868 Glucitol operon activator protein (GutM); Region: GutM; cl01890 706191002869 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 706191002870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706191002871 NAD(P) binding site [chemical binding]; other site 706191002872 active site 706191002873 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 706191002874 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 706191002875 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 706191002876 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 706191002877 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 706191002878 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 706191002879 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 706191002880 Na binding site [ion binding]; other site 706191002881 putative substrate binding site [chemical binding]; other site 706191002882 Transcriptional regulators [Transcription]; Region: GntR; COG1802 706191002883 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191002884 DNA-binding site [nucleotide binding]; DNA binding site 706191002885 FCD domain; Region: FCD; pfam07729 706191002886 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 706191002887 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 706191002888 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 706191002889 active site 706191002890 catalytic site [active] 706191002891 tetramer interface [polypeptide binding]; other site 706191002892 hypothetical protein; Provisional; Region: PRK07490 706191002893 intersubunit interface [polypeptide binding]; other site 706191002894 active site 706191002895 Zn2+ binding site [ion binding]; other site 706191002896 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191002897 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 706191002898 substrate binding pocket [chemical binding]; other site 706191002899 membrane-bound complex binding site; other site 706191002900 hinge residues; other site 706191002901 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 706191002902 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 706191002903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191002904 dimer interface [polypeptide binding]; other site 706191002905 conserved gate region; other site 706191002906 putative PBP binding loops; other site 706191002907 ABC-ATPase subunit interface; other site 706191002908 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 706191002909 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191002910 Walker A/P-loop; other site 706191002911 ATP binding site [chemical binding]; other site 706191002912 Q-loop/lid; other site 706191002913 ABC transporter signature motif; other site 706191002914 Walker B; other site 706191002915 D-loop; other site 706191002916 H-loop/switch region; other site 706191002917 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191002918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191002919 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 706191002920 putative substrate binding pocket [chemical binding]; other site 706191002921 dimerization interface [polypeptide binding]; other site 706191002922 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706191002923 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 706191002924 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 706191002925 homotrimer interaction site [polypeptide binding]; other site 706191002926 putative active site [active] 706191002927 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 706191002928 acetylornithine deacetylase; Provisional; Region: PRK07522 706191002929 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 706191002930 metal binding site [ion binding]; metal-binding site 706191002931 putative dimer interface [polypeptide binding]; other site 706191002932 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 706191002933 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 706191002934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191002935 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 706191002936 dimerization interface [polypeptide binding]; other site 706191002937 substrate binding pocket [chemical binding]; other site 706191002938 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 706191002939 SnoaL-like domain; Region: SnoaL_3; pfam13474 706191002940 amidase; Provisional; Region: PRK09201 706191002941 Amidase; Region: Amidase; pfam01425 706191002942 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 706191002943 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 706191002944 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 706191002945 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 706191002946 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 706191002947 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 706191002948 putative active site [active] 706191002949 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 706191002950 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191002951 substrate binding pocket [chemical binding]; other site 706191002952 membrane-bound complex binding site; other site 706191002953 hinge residues; other site 706191002954 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 706191002955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191002956 dimer interface [polypeptide binding]; other site 706191002957 conserved gate region; other site 706191002958 putative PBP binding loops; other site 706191002959 ABC-ATPase subunit interface; other site 706191002960 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 706191002961 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 706191002962 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 706191002963 Walker A/P-loop; other site 706191002964 ATP binding site [chemical binding]; other site 706191002965 Q-loop/lid; other site 706191002966 ABC transporter signature motif; other site 706191002967 Walker B; other site 706191002968 D-loop; other site 706191002969 H-loop/switch region; other site 706191002970 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 706191002971 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 706191002972 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 706191002973 catalytic residue [active] 706191002974 allantoate amidohydrolase; Reviewed; Region: PRK09290 706191002975 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 706191002976 active site 706191002977 metal binding site [ion binding]; metal-binding site 706191002978 dimer interface [polypeptide binding]; other site 706191002979 OHCU decarboxylase; Region: UraD_2; TIGR03180 706191002980 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 706191002981 active site 706191002982 homotetramer interface [polypeptide binding]; other site 706191002983 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 706191002984 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 706191002985 heme binding site [chemical binding]; other site 706191002986 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 706191002987 heme binding site [chemical binding]; other site 706191002988 C-N hydrolase family amidase; Provisional; Region: PRK10438 706191002989 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 706191002990 putative active site [active] 706191002991 catalytic triad [active] 706191002992 dimer interface [polypeptide binding]; other site 706191002993 multimer interface [polypeptide binding]; other site 706191002994 methionine aminotransferase; Validated; Region: PRK09082 706191002995 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706191002996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191002997 homodimer interface [polypeptide binding]; other site 706191002998 catalytic residue [active] 706191002999 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 706191003000 intersubunit interface [polypeptide binding]; other site 706191003001 active site 706191003002 Zn2+ binding site [ion binding]; other site 706191003003 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 706191003004 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 706191003005 motif II; other site 706191003006 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 706191003007 Cupin domain; Region: Cupin_2; cl17218 706191003008 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 706191003009 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 706191003010 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 706191003011 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 706191003012 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706191003013 active site 706191003014 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 706191003015 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 706191003016 dimer interface [polypeptide binding]; other site 706191003017 active site 706191003018 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 706191003019 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 706191003020 putative active site [active] 706191003021 putative dimer interface [polypeptide binding]; other site 706191003022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 706191003023 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 706191003024 active site 706191003025 DNA polymerase IV; Validated; Region: PRK02406 706191003026 DNA binding site [nucleotide binding] 706191003027 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 706191003028 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 706191003029 putative ligand binding site [chemical binding]; other site 706191003030 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706191003031 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 706191003032 TM-ABC transporter signature motif; other site 706191003033 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 706191003034 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 706191003035 Walker A/P-loop; other site 706191003036 ATP binding site [chemical binding]; other site 706191003037 Q-loop/lid; other site 706191003038 ABC transporter signature motif; other site 706191003039 Walker B; other site 706191003040 D-loop; other site 706191003041 H-loop/switch region; other site 706191003042 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 706191003043 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 706191003044 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 706191003045 tetramer interface [polypeptide binding]; other site 706191003046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191003047 catalytic residue [active] 706191003048 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 706191003049 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 706191003050 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 706191003051 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 706191003052 metal binding site [ion binding]; metal-binding site 706191003053 dimer interface [polypeptide binding]; other site 706191003054 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 706191003055 active site 706191003056 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 706191003057 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 706191003058 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 706191003059 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 706191003060 trimer interface [polypeptide binding]; other site 706191003061 eyelet of channel; other site 706191003062 gamma-glutamyl kinase; Provisional; Region: PRK05429 706191003063 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 706191003064 nucleotide binding site [chemical binding]; other site 706191003065 homotetrameric interface [polypeptide binding]; other site 706191003066 putative phosphate binding site [ion binding]; other site 706191003067 putative allosteric binding site; other site 706191003068 PUA domain; Region: PUA; pfam01472 706191003069 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 706191003070 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 706191003071 putative catalytic cysteine [active] 706191003072 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 706191003073 non-specific DNA binding site [nucleotide binding]; other site 706191003074 salt bridge; other site 706191003075 sequence-specific DNA binding site [nucleotide binding]; other site 706191003076 Predicted transcriptional regulator [Transcription]; Region: COG2932 706191003077 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 706191003078 Catalytic site [active] 706191003079 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 706191003080 catalytic residue [active] 706191003081 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 706191003082 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 706191003083 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 706191003084 PAS domain; Region: PAS; smart00091 706191003085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191003086 Walker A motif; other site 706191003087 ATP binding site [chemical binding]; other site 706191003088 Walker B motif; other site 706191003089 arginine finger; other site 706191003090 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706191003091 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 706191003092 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 706191003093 dimer interface [polypeptide binding]; other site 706191003094 active site 706191003095 metal binding site [ion binding]; metal-binding site 706191003096 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 706191003097 Dak1 domain; Region: Dak1; pfam02733 706191003098 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 706191003099 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 706191003100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 706191003101 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 706191003102 dimerization domain swap beta strand [polypeptide binding]; other site 706191003103 regulatory protein interface [polypeptide binding]; other site 706191003104 active site 706191003105 regulatory phosphorylation site [posttranslational modification]; other site 706191003106 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 706191003107 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 706191003108 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 706191003109 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 706191003110 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 706191003111 haemagglutination activity domain; Region: Haemagg_act; pfam05860 706191003112 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 706191003113 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 706191003114 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 706191003115 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 706191003116 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 706191003117 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 706191003118 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706191003119 non-specific DNA binding site [nucleotide binding]; other site 706191003120 salt bridge; other site 706191003121 sequence-specific DNA binding site [nucleotide binding]; other site 706191003122 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 706191003123 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191003124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191003125 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 706191003126 putative substrate binding pocket [chemical binding]; other site 706191003127 putative dimerization interface [polypeptide binding]; other site 706191003128 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 706191003129 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 706191003130 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 706191003131 DNA-binding site [nucleotide binding]; DNA binding site 706191003132 RNA-binding motif; other site 706191003133 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 706191003134 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706191003135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191003136 active site 706191003137 phosphorylation site [posttranslational modification] 706191003138 intermolecular recognition site; other site 706191003139 dimerization interface [polypeptide binding]; other site 706191003140 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 706191003141 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 706191003142 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 706191003143 ATP binding site [chemical binding]; other site 706191003144 Mg++ binding site [ion binding]; other site 706191003145 motif III; other site 706191003146 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 706191003147 nucleotide binding region [chemical binding]; other site 706191003148 ATP-binding site [chemical binding]; other site 706191003149 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 706191003150 putative RNA binding site [nucleotide binding]; other site 706191003151 putative deaminase; Validated; Region: PRK06846 706191003152 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 706191003153 active site 706191003154 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191003155 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 706191003156 dimerization interface [polypeptide binding]; other site 706191003157 putative cyanate transporter; Provisional; Region: cynX; PRK09705 706191003158 L-lactate permease; Provisional; Region: PRK10420 706191003159 glycolate transporter; Provisional; Region: PRK09695 706191003160 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 706191003161 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191003162 DNA-binding site [nucleotide binding]; DNA binding site 706191003163 FCD domain; Region: FCD; pfam07729 706191003164 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 706191003165 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 706191003166 phosphate binding site [ion binding]; other site 706191003167 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 706191003168 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 706191003169 active site 706191003170 P-loop; other site 706191003171 phosphorylation site [posttranslational modification] 706191003172 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 706191003173 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 706191003174 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 706191003175 active site 706191003176 methionine cluster; other site 706191003177 phosphorylation site [posttranslational modification] 706191003178 metal binding site [ion binding]; metal-binding site 706191003179 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 706191003180 beta-galactosidase; Region: BGL; TIGR03356 706191003181 Transcriptional regulators [Transcription]; Region: PurR; COG1609 706191003182 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191003183 DNA binding site [nucleotide binding] 706191003184 domain linker motif; other site 706191003185 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706191003186 CAAX protease self-immunity; Region: Abi; pfam02517 706191003187 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 706191003188 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 706191003189 anti-RssB factor; Provisional; Region: PRK10244 706191003190 hypothetical protein; Provisional; Region: PRK11505 706191003191 psiF repeat; Region: PsiF_repeat; pfam07769 706191003192 psiF repeat; Region: PsiF_repeat; pfam07769 706191003193 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 706191003194 iron-sulfur cluster [ion binding]; other site 706191003195 [2Fe-2S] cluster binding site [ion binding]; other site 706191003196 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 706191003197 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706191003198 pyrroline-5-carboxylate reductase; Region: PLN02688 706191003199 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 706191003200 hypothetical protein; Validated; Region: PRK00124 706191003201 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 706191003202 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 706191003203 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 706191003204 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 706191003205 ADP binding site [chemical binding]; other site 706191003206 magnesium binding site [ion binding]; other site 706191003207 putative shikimate binding site; other site 706191003208 hypothetical protein; Provisional; Region: PRK10380 706191003209 hypothetical protein; Provisional; Region: PRK10579 706191003210 recombination associated protein; Reviewed; Region: rdgC; PRK00321 706191003211 fructokinase; Reviewed; Region: PRK09557 706191003212 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 706191003213 nucleotide binding site [chemical binding]; other site 706191003214 TolA C-terminal; Region: TolA; pfam06519 706191003215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191003216 AAA domain; Region: AAA_23; pfam13476 706191003217 Walker A/P-loop; other site 706191003218 ATP binding site [chemical binding]; other site 706191003219 Q-loop/lid; other site 706191003220 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191003221 ABC transporter signature motif; other site 706191003222 Walker B; other site 706191003223 D-loop; other site 706191003224 H-loop/switch region; other site 706191003225 exonuclease subunit SbcD; Provisional; Region: PRK10966 706191003226 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 706191003227 active site 706191003228 metal binding site [ion binding]; metal-binding site 706191003229 DNA binding site [nucleotide binding] 706191003230 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 706191003231 transcriptional regulator PhoB; Provisional; Region: PRK10161 706191003232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191003233 active site 706191003234 phosphorylation site [posttranslational modification] 706191003235 intermolecular recognition site; other site 706191003236 dimerization interface [polypeptide binding]; other site 706191003237 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706191003238 DNA binding site [nucleotide binding] 706191003239 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 706191003240 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 706191003241 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706191003242 putative active site [active] 706191003243 heme pocket [chemical binding]; other site 706191003244 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706191003245 dimer interface [polypeptide binding]; other site 706191003246 phosphorylation site [posttranslational modification] 706191003247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191003248 ATP binding site [chemical binding]; other site 706191003249 Mg2+ binding site [ion binding]; other site 706191003250 G-X-G motif; other site 706191003251 PBP superfamily domain; Region: PBP_like_2; cl17296 706191003252 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 706191003253 substrate binding site [chemical binding]; other site 706191003254 THF binding site; other site 706191003255 zinc-binding site [ion binding]; other site 706191003256 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 706191003257 putative proline-specific permease; Provisional; Region: proY; PRK10580 706191003258 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 706191003259 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 706191003260 catalytic core [active] 706191003261 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 706191003262 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 706191003263 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 706191003264 active site 706191003265 dimerization interface [polypeptide binding]; other site 706191003266 Protein of unknown function, DUF479; Region: DUF479; cl01203 706191003267 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 706191003268 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 706191003269 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 706191003270 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 706191003271 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 706191003272 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 706191003273 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 706191003274 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 706191003275 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 706191003276 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 706191003277 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 706191003278 Protein export membrane protein; Region: SecD_SecF; pfam02355 706191003279 hypothetical protein; Provisional; Region: PRK11530 706191003280 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 706191003281 ATP cone domain; Region: ATP-cone; pfam03477 706191003282 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 706191003283 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 706191003284 catalytic motif [active] 706191003285 Zn binding site [ion binding]; other site 706191003286 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 706191003287 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 706191003288 homopentamer interface [polypeptide binding]; other site 706191003289 active site 706191003290 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 706191003291 putative RNA binding site [nucleotide binding]; other site 706191003292 thiamine monophosphate kinase; Provisional; Region: PRK05731 706191003293 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 706191003294 ATP binding site [chemical binding]; other site 706191003295 dimerization interface [polypeptide binding]; other site 706191003296 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 706191003297 tetramer interfaces [polypeptide binding]; other site 706191003298 binuclear metal-binding site [ion binding]; other site 706191003299 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 706191003300 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 706191003301 active site 706191003302 catalytic tetrad [active] 706191003303 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 706191003304 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 706191003305 TPP-binding site; other site 706191003306 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 706191003307 PYR/PP interface [polypeptide binding]; other site 706191003308 dimer interface [polypeptide binding]; other site 706191003309 TPP binding site [chemical binding]; other site 706191003310 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 706191003311 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 706191003312 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 706191003313 substrate binding pocket [chemical binding]; other site 706191003314 chain length determination region; other site 706191003315 substrate-Mg2+ binding site; other site 706191003316 catalytic residues [active] 706191003317 aspartate-rich region 1; other site 706191003318 active site lid residues [active] 706191003319 aspartate-rich region 2; other site 706191003320 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 706191003321 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 706191003322 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 706191003323 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 706191003324 Ligand Binding Site [chemical binding]; other site 706191003325 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 706191003326 active site residue [active] 706191003327 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 706191003328 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 706191003329 conserved cys residue [active] 706191003330 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 706191003331 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 706191003332 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 706191003333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 706191003334 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 706191003335 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 706191003336 GAF domain; Region: GAF; pfam01590 706191003337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191003338 Walker A motif; other site 706191003339 ATP binding site [chemical binding]; other site 706191003340 Walker B motif; other site 706191003341 arginine finger; other site 706191003342 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706191003343 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 706191003344 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 706191003345 NAD(P) binding site [chemical binding]; other site 706191003346 catalytic residues [active] 706191003347 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 706191003348 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 706191003349 NAD binding site [chemical binding]; other site 706191003350 substrate binding site [chemical binding]; other site 706191003351 catalytic Zn binding site [ion binding]; other site 706191003352 tetramer interface [polypeptide binding]; other site 706191003353 structural Zn binding site [ion binding]; other site 706191003354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191003355 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706191003356 putative substrate translocation pore; other site 706191003357 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 706191003358 UbiA prenyltransferase family; Region: UbiA; pfam01040 706191003359 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 706191003360 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 706191003361 Subunit I/III interface [polypeptide binding]; other site 706191003362 Subunit III/IV interface [polypeptide binding]; other site 706191003363 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 706191003364 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 706191003365 D-pathway; other site 706191003366 Putative ubiquinol binding site [chemical binding]; other site 706191003367 Low-spin heme (heme b) binding site [chemical binding]; other site 706191003368 Putative water exit pathway; other site 706191003369 Binuclear center (heme o3/CuB) [ion binding]; other site 706191003370 K-pathway; other site 706191003371 Putative proton exit pathway; other site 706191003372 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 706191003373 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 706191003374 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 706191003375 muropeptide transporter; Reviewed; Region: ampG; PRK11902 706191003376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191003377 putative substrate translocation pore; other site 706191003378 hypothetical protein; Provisional; Region: PRK11627 706191003379 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 706191003380 transcriptional regulator BolA; Provisional; Region: PRK11628 706191003381 trigger factor; Provisional; Region: tig; PRK01490 706191003382 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 706191003383 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 706191003384 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 706191003385 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 706191003386 oligomer interface [polypeptide binding]; other site 706191003387 active site residues [active] 706191003388 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 706191003389 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 706191003390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191003391 Walker A motif; other site 706191003392 ATP binding site [chemical binding]; other site 706191003393 Walker B motif; other site 706191003394 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 706191003395 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 706191003396 Found in ATP-dependent protease La (LON); Region: LON; smart00464 706191003397 Found in ATP-dependent protease La (LON); Region: LON; smart00464 706191003398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191003399 Walker A motif; other site 706191003400 ATP binding site [chemical binding]; other site 706191003401 Walker B motif; other site 706191003402 arginine finger; other site 706191003403 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 706191003404 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 706191003405 IHF dimer interface [polypeptide binding]; other site 706191003406 IHF - DNA interface [nucleotide binding]; other site 706191003407 periplasmic folding chaperone; Provisional; Region: PRK10788 706191003408 SurA N-terminal domain; Region: SurA_N_3; cl07813 706191003409 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 706191003410 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 706191003411 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 706191003412 active site 706191003413 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 706191003414 Ligand Binding Site [chemical binding]; other site 706191003415 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 706191003416 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 706191003417 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 706191003418 catalytic residue [active] 706191003419 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 706191003420 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706191003421 putative DNA binding site [nucleotide binding]; other site 706191003422 putative Zn2+ binding site [ion binding]; other site 706191003423 AsnC family; Region: AsnC_trans_reg; pfam01037 706191003424 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 706191003425 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 706191003426 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191003427 Walker A/P-loop; other site 706191003428 ATP binding site [chemical binding]; other site 706191003429 Q-loop/lid; other site 706191003430 ABC transporter signature motif; other site 706191003431 Walker B; other site 706191003432 D-loop; other site 706191003433 H-loop/switch region; other site 706191003434 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 706191003435 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 706191003436 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191003437 Walker A/P-loop; other site 706191003438 ATP binding site [chemical binding]; other site 706191003439 Q-loop/lid; other site 706191003440 ABC transporter signature motif; other site 706191003441 Walker B; other site 706191003442 D-loop; other site 706191003443 H-loop/switch region; other site 706191003444 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 706191003445 Nitrogen regulatory protein P-II; Region: P-II; smart00938 706191003446 ammonium transporter; Provisional; Region: PRK10666 706191003447 acyl-CoA thioesterase II; Provisional; Region: PRK10526 706191003448 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 706191003449 active site 706191003450 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 706191003451 catalytic triad [active] 706191003452 dimer interface [polypeptide binding]; other site 706191003453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 706191003454 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 706191003455 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 706191003456 DNA binding site [nucleotide binding] 706191003457 active site 706191003458 gene expression modulator; Provisional; Region: PRK10945 706191003459 Hha toxicity attenuator; Provisional; Region: PRK10667 706191003460 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 706191003461 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 706191003462 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 706191003463 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 706191003464 ABC-ATPase subunit interface; other site 706191003465 dimer interface [polypeptide binding]; other site 706191003466 putative PBP binding regions; other site 706191003467 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 706191003468 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 706191003469 metal binding site [ion binding]; metal-binding site 706191003470 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 706191003471 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 706191003472 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 706191003473 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 706191003474 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706191003475 HlyD family secretion protein; Region: HlyD_3; pfam13437 706191003476 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 706191003477 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706191003478 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 706191003479 hypothetical protein; Provisional; Region: PRK11038 706191003480 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 706191003481 hypothetical protein; Provisional; Region: PRK10527 706191003482 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 706191003483 active site 706191003484 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 706191003485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191003486 Walker A motif; other site 706191003487 ATP binding site [chemical binding]; other site 706191003488 Walker B motif; other site 706191003489 DNA polymerase III subunit delta'; Validated; Region: PRK08485 706191003490 arginine finger; other site 706191003491 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 706191003492 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 706191003493 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 706191003494 hypothetical protein; Validated; Region: PRK00153 706191003495 recombination protein RecR; Reviewed; Region: recR; PRK00076 706191003496 RecR protein; Region: RecR; pfam02132 706191003497 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 706191003498 putative active site [active] 706191003499 putative metal-binding site [ion binding]; other site 706191003500 tetramer interface [polypeptide binding]; other site 706191003501 heat shock protein 90; Provisional; Region: PRK05218 706191003502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191003503 ATP binding site [chemical binding]; other site 706191003504 Mg2+ binding site [ion binding]; other site 706191003505 G-X-G motif; other site 706191003506 adenylate kinase; Reviewed; Region: adk; PRK00279 706191003507 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 706191003508 AMP-binding site [chemical binding]; other site 706191003509 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 706191003510 inosine/guanosine kinase; Provisional; Region: PRK15074 706191003511 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 706191003512 putative cation:proton antiport protein; Provisional; Region: PRK10669 706191003513 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 706191003514 TrkA-N domain; Region: TrkA_N; pfam02254 706191003515 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 706191003516 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 706191003517 active site 706191003518 metal binding site [ion binding]; metal-binding site 706191003519 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 706191003520 Predicted membrane protein [Function unknown]; Region: COG4125 706191003521 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 706191003522 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 706191003523 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191003524 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191003525 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 706191003526 dimerization interface [polypeptide binding]; other site 706191003527 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 706191003528 putative deacylase active site [active] 706191003529 TraB family; Region: TraB; cl12050 706191003530 copper exporting ATPase; Provisional; Region: copA; PRK10671 706191003531 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 706191003532 metal-binding site [ion binding] 706191003533 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 706191003534 metal-binding site [ion binding] 706191003535 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 706191003536 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191003537 motif II; other site 706191003538 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 706191003539 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 706191003540 DNA binding residues [nucleotide binding] 706191003541 dimer interface [polypeptide binding]; other site 706191003542 copper binding site [ion binding]; other site 706191003543 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 706191003544 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 706191003545 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 706191003546 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 706191003547 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 706191003548 oxidoreductase; Provisional; Region: PRK08017 706191003549 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 706191003550 NADP binding site [chemical binding]; other site 706191003551 active site 706191003552 steroid binding site; other site 706191003553 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 706191003554 active site 706191003555 catalytic triad [active] 706191003556 oxyanion hole [active] 706191003557 switch loop; other site 706191003558 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 706191003559 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 706191003560 Walker A/P-loop; other site 706191003561 ATP binding site [chemical binding]; other site 706191003562 Q-loop/lid; other site 706191003563 ABC transporter signature motif; other site 706191003564 Walker B; other site 706191003565 D-loop; other site 706191003566 H-loop/switch region; other site 706191003567 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706191003568 FtsX-like permease family; Region: FtsX; pfam02687 706191003569 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 706191003570 ATP-grasp domain; Region: ATP-grasp; pfam02222 706191003571 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 706191003572 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 706191003573 Predicted membrane protein [Function unknown]; Region: COG4325 706191003574 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 706191003575 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 706191003576 putative active site [active] 706191003577 putative metal binding site [ion binding]; other site 706191003578 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 706191003579 substrate binding site [chemical binding]; other site 706191003580 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 706191003581 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 706191003582 active site 706191003583 HIGH motif; other site 706191003584 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 706191003585 KMSKS motif; other site 706191003586 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 706191003587 tRNA binding surface [nucleotide binding]; other site 706191003588 anticodon binding site; other site 706191003589 Predicted ATPase [General function prediction only]; Region: COG4637 706191003590 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191003591 Walker A/P-loop; other site 706191003592 ATP binding site [chemical binding]; other site 706191003593 ribosome-associated protein; Provisional; Region: PRK11507 706191003594 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 706191003595 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 706191003596 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 706191003597 homodimer interface [polypeptide binding]; other site 706191003598 NADP binding site [chemical binding]; other site 706191003599 substrate binding site [chemical binding]; other site 706191003600 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 706191003601 Restriction endonuclease; Region: Mrr_cat; pfam04471 706191003602 Terminase small subunit; Region: Terminase_2; pfam03592 706191003603 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 706191003604 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 706191003605 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 706191003606 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 706191003607 Ligand binding site; other site 706191003608 Putative Catalytic site; other site 706191003609 DXD motif; other site 706191003610 Predicted membrane protein [Function unknown]; Region: COG2246 706191003611 GtrA-like protein; Region: GtrA; pfam04138 706191003612 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 706191003613 PAAR motif; Region: PAAR_motif; pfam05488 706191003614 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 706191003615 RHS Repeat; Region: RHS_repeat; pfam05593 706191003616 RHS Repeat; Region: RHS_repeat; cl11982 706191003617 RHS Repeat; Region: RHS_repeat; cl11982 706191003618 RHS protein; Region: RHS; pfam03527 706191003619 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 706191003620 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 706191003621 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 706191003622 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 706191003623 peptide binding site [polypeptide binding]; other site 706191003624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 706191003625 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 706191003626 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 706191003627 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 706191003628 hexamer (dimer of trimers) interface [polypeptide binding]; other site 706191003629 substrate binding site [chemical binding]; other site 706191003630 trimer interface [polypeptide binding]; other site 706191003631 Mn binding site [ion binding]; other site 706191003632 putative symporter YagG; Provisional; Region: PRK09669 706191003633 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 706191003634 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 706191003635 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 706191003636 hypothetical protein; Provisional; Region: PRK09897 706191003637 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 706191003638 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 706191003639 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 706191003640 Autotransporter beta-domain; Region: Autotransporter; pfam03797 706191003641 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 706191003642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191003643 putative substrate translocation pore; other site 706191003644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191003645 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 706191003646 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 706191003647 Methyltransferase domain; Region: Methyltransf_31; pfam13847 706191003648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191003649 S-adenosylmethionine binding site [chemical binding]; other site 706191003650 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 706191003651 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 706191003652 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 706191003653 putative lipid kinase; Reviewed; Region: PRK13057 706191003654 Cupin domain; Region: Cupin_2; cl17218 706191003655 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 706191003656 Domain of unknown function DUF20; Region: UPF0118; pfam01594 706191003657 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 706191003658 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 706191003659 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 706191003660 active site 706191003661 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 706191003662 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 706191003663 NAD binding site [chemical binding]; other site 706191003664 catalytic Zn binding site [ion binding]; other site 706191003665 structural Zn binding site [ion binding]; other site 706191003666 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 706191003667 serine transporter; Region: stp; TIGR00814 706191003668 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 706191003669 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 706191003670 intersubunit interface [polypeptide binding]; other site 706191003671 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 706191003672 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 706191003673 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191003674 active site 706191003675 motif I; other site 706191003676 motif II; other site 706191003677 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191003678 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 706191003679 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 706191003680 active site 706191003681 NAD binding site [chemical binding]; other site 706191003682 metal binding site [ion binding]; metal-binding site 706191003683 high-affinity gluconate transporter; Provisional; Region: PRK14984 706191003684 gluconate transporter; Region: gntP; TIGR00791 706191003685 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 706191003686 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 706191003687 DNA-binding site [nucleotide binding]; DNA binding site 706191003688 RNA-binding motif; other site 706191003689 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191003690 Coenzyme A binding pocket [chemical binding]; other site 706191003691 Predicted amidohydrolase [General function prediction only]; Region: COG0388 706191003692 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 706191003693 putative active site [active] 706191003694 catalytic triad [active] 706191003695 putative dimer interface [polypeptide binding]; other site 706191003696 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 706191003697 lipoyl synthase; Provisional; Region: PRK05481 706191003698 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706191003699 FeS/SAM binding site; other site 706191003700 lipoate-protein ligase B; Provisional; Region: PRK14342 706191003701 hypothetical protein; Provisional; Region: PRK04998 706191003702 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 706191003703 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 706191003704 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 706191003705 rare lipoprotein A; Provisional; Region: PRK10672 706191003706 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 706191003707 Sporulation related domain; Region: SPOR; pfam05036 706191003708 cell wall shape-determining protein; Provisional; Region: PRK10794 706191003709 penicillin-binding protein 2; Provisional; Region: PRK10795 706191003710 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 706191003711 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 706191003712 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 706191003713 ribosome-associated protein; Provisional; Region: PRK11538 706191003714 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 706191003715 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 706191003716 active site 706191003717 (T/H)XGH motif; other site 706191003718 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 706191003719 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 706191003720 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 706191003721 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 706191003722 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 706191003723 HIGH motif; other site 706191003724 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 706191003725 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 706191003726 active site 706191003727 KMSKS motif; other site 706191003728 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 706191003729 tRNA binding surface [nucleotide binding]; other site 706191003730 hypothetical protein; Provisional; Region: PRK11032 706191003731 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 706191003732 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 706191003733 Walker A/P-loop; other site 706191003734 ATP binding site [chemical binding]; other site 706191003735 Q-loop/lid; other site 706191003736 ABC transporter signature motif; other site 706191003737 Walker B; other site 706191003738 D-loop; other site 706191003739 H-loop/switch region; other site 706191003740 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 706191003741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191003742 dimer interface [polypeptide binding]; other site 706191003743 conserved gate region; other site 706191003744 putative PBP binding loops; other site 706191003745 ABC-ATPase subunit interface; other site 706191003746 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 706191003747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191003748 dimer interface [polypeptide binding]; other site 706191003749 conserved gate region; other site 706191003750 putative PBP binding loops; other site 706191003751 ABC-ATPase subunit interface; other site 706191003752 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 706191003753 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191003754 substrate binding pocket [chemical binding]; other site 706191003755 membrane-bound complex binding site; other site 706191003756 hinge residues; other site 706191003757 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 706191003758 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 706191003759 putative active site [active] 706191003760 catalytic triad [active] 706191003761 putative dimer interface [polypeptide binding]; other site 706191003762 FOG: CBS domain [General function prediction only]; Region: COG0517 706191003763 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 706191003764 Transporter associated domain; Region: CorC_HlyC; smart01091 706191003765 metal-binding heat shock protein; Provisional; Region: PRK00016 706191003766 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 706191003767 PhoH-like protein; Region: PhoH; pfam02562 706191003768 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 706191003769 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 706191003770 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706191003771 FeS/SAM binding site; other site 706191003772 TRAM domain; Region: TRAM; pfam01938 706191003773 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 706191003774 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 706191003775 asparagine synthetase B; Provisional; Region: asnB; PRK09431 706191003776 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 706191003777 active site 706191003778 dimer interface [polypeptide binding]; other site 706191003779 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 706191003780 Ligand Binding Site [chemical binding]; other site 706191003781 Molecular Tunnel; other site 706191003782 UMP phosphatase; Provisional; Region: PRK10444 706191003783 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191003784 active site 706191003785 motif I; other site 706191003786 motif II; other site 706191003787 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191003788 MarR family; Region: MarR; pfam01047 706191003789 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 706191003790 ROK family; Region: ROK; pfam00480 706191003791 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 706191003792 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 706191003793 active site 706191003794 dimer interface [polypeptide binding]; other site 706191003795 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 706191003796 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 706191003797 active site 706191003798 trimer interface [polypeptide binding]; other site 706191003799 allosteric site; other site 706191003800 active site lid [active] 706191003801 hexamer (dimer of trimers) interface [polypeptide binding]; other site 706191003802 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 706191003803 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 706191003804 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 706191003805 active site turn [active] 706191003806 phosphorylation site [posttranslational modification] 706191003807 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 706191003808 HPr interaction site; other site 706191003809 glycerol kinase (GK) interaction site [polypeptide binding]; other site 706191003810 active site 706191003811 phosphorylation site [posttranslational modification] 706191003812 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 706191003813 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 706191003814 active site 706191003815 HIGH motif; other site 706191003816 nucleotide binding site [chemical binding]; other site 706191003817 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 706191003818 KMSKS motif; other site 706191003819 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 706191003820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 706191003821 ferric uptake regulator; Provisional; Region: fur; PRK09462 706191003822 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 706191003823 metal binding site 2 [ion binding]; metal-binding site 706191003824 putative DNA binding helix; other site 706191003825 metal binding site 1 [ion binding]; metal-binding site 706191003826 dimer interface [polypeptide binding]; other site 706191003827 structural Zn2+ binding site [ion binding]; other site 706191003828 flavodoxin FldA; Validated; Region: PRK09267 706191003829 LexA regulated protein; Provisional; Region: PRK11675 706191003830 acyl-CoA esterase; Provisional; Region: PRK10673 706191003831 PGAP1-like protein; Region: PGAP1; pfam07819 706191003832 replication initiation regulator SeqA; Provisional; Region: PRK11187 706191003833 phosphoglucomutase; Validated; Region: PRK07564 706191003834 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 706191003835 active site 706191003836 substrate binding site [chemical binding]; other site 706191003837 metal binding site [ion binding]; metal-binding site 706191003838 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 706191003839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191003840 active site 706191003841 phosphorylation site [posttranslational modification] 706191003842 intermolecular recognition site; other site 706191003843 dimerization interface [polypeptide binding]; other site 706191003844 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706191003845 DNA binding site [nucleotide binding] 706191003846 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 706191003847 Protein of unknown function (DUF523); Region: DUF523; pfam04463 706191003848 Uncharacterized conserved protein [Function unknown]; Region: COG3272 706191003849 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 706191003850 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 706191003851 DNA photolyase; Region: DNA_photolyase; pfam00875 706191003852 Uncharacterized conserved protein [Function unknown]; Region: COG0327 706191003853 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 706191003854 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 706191003855 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 706191003856 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 706191003857 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 706191003858 putative active site [active] 706191003859 Protein of unknown function (DUF969); Region: DUF969; pfam06149 706191003860 Predicted membrane protein [Function unknown]; Region: COG3817 706191003861 Protein of unknown function (DUF979); Region: DUF979; pfam06166 706191003862 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 706191003863 putative substrate binding pocket [chemical binding]; other site 706191003864 AC domain interface; other site 706191003865 catalytic triad [active] 706191003866 AB domain interface; other site 706191003867 interchain disulfide; other site 706191003868 endonuclease VIII; Provisional; Region: PRK10445 706191003869 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 706191003870 DNA binding site [nucleotide binding] 706191003871 catalytic residue [active] 706191003872 H2TH interface [polypeptide binding]; other site 706191003873 putative catalytic residues [active] 706191003874 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 706191003875 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 706191003876 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 706191003877 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 706191003878 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 706191003879 dimer interface [polypeptide binding]; other site 706191003880 active site 706191003881 citrylCoA binding site [chemical binding]; other site 706191003882 NADH binding [chemical binding]; other site 706191003883 cationic pore residues; other site 706191003884 oxalacetate/citrate binding site [chemical binding]; other site 706191003885 coenzyme A binding site [chemical binding]; other site 706191003886 catalytic triad [active] 706191003887 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 706191003888 Iron-sulfur protein interface; other site 706191003889 proximal quinone binding site [chemical binding]; other site 706191003890 SdhD (CybS) interface [polypeptide binding]; other site 706191003891 proximal heme binding site [chemical binding]; other site 706191003892 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 706191003893 cardiolipin binding site; other site 706191003894 SdhC subunit interface [polypeptide binding]; other site 706191003895 proximal heme binding site [chemical binding]; other site 706191003896 Iron-sulfur protein interface; other site 706191003897 proximal quinone binding site [chemical binding]; other site 706191003898 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 706191003899 L-aspartate oxidase; Provisional; Region: PRK06175 706191003900 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 706191003901 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 706191003902 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 706191003903 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 706191003904 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 706191003905 TPP-binding site [chemical binding]; other site 706191003906 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 706191003907 dimer interface [polypeptide binding]; other site 706191003908 PYR/PP interface [polypeptide binding]; other site 706191003909 TPP binding site [chemical binding]; other site 706191003910 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 706191003911 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 706191003912 E3 interaction surface; other site 706191003913 lipoyl attachment site [posttranslational modification]; other site 706191003914 e3 binding domain; Region: E3_binding; pfam02817 706191003915 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 706191003916 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 706191003917 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 706191003918 CoA-ligase; Region: Ligase_CoA; pfam00549 706191003919 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 706191003920 CoA binding domain; Region: CoA_binding; pfam02629 706191003921 CoA-ligase; Region: Ligase_CoA; pfam00549 706191003922 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 706191003923 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 706191003924 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 706191003925 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 706191003926 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 706191003927 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 706191003928 active site 706191003929 colicin uptake protein TolQ; Provisional; Region: PRK10801 706191003930 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 706191003931 colicin uptake protein TolR; Provisional; Region: PRK11024 706191003932 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 706191003933 TolA C-terminal; Region: TolA; pfam06519 706191003934 translocation protein TolB; Provisional; Region: tolB; PRK03629 706191003935 TolB amino-terminal domain; Region: TolB_N; pfam04052 706191003936 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 706191003937 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 706191003938 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 706191003939 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 706191003940 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 706191003941 ligand binding site [chemical binding]; other site 706191003942 tol-pal system protein YbgF; Provisional; Region: PRK10803 706191003943 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706191003944 TPR motif; other site 706191003945 binding surface 706191003946 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 706191003947 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706191003948 dimerization interface [polypeptide binding]; other site 706191003949 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191003950 dimer interface [polypeptide binding]; other site 706191003951 putative CheW interface [polypeptide binding]; other site 706191003952 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 706191003953 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 706191003954 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191003955 AlkA N-terminal domain; Region: AlkA_N; pfam06029 706191003956 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 706191003957 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 706191003958 minor groove reading motif; other site 706191003959 helix-hairpin-helix signature motif; other site 706191003960 substrate binding pocket [chemical binding]; other site 706191003961 active site 706191003962 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 706191003963 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 706191003964 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 706191003965 DNA binding site [nucleotide binding] 706191003966 active site 706191003967 quinolinate synthetase; Provisional; Region: PRK09375 706191003968 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 706191003969 zinc transporter ZitB; Provisional; Region: PRK03557 706191003970 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 706191003971 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191003972 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 706191003973 substrate binding pocket [chemical binding]; other site 706191003974 membrane-bound complex binding site; other site 706191003975 hinge residues; other site 706191003976 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706191003977 dimer interface [polypeptide binding]; other site 706191003978 phosphorylation site [posttranslational modification] 706191003979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191003980 ATP binding site [chemical binding]; other site 706191003981 Mg2+ binding site [ion binding]; other site 706191003982 G-X-G motif; other site 706191003983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191003984 active site 706191003985 phosphorylation site [posttranslational modification] 706191003986 intermolecular recognition site; other site 706191003987 Hpt domain; Region: Hpt; pfam01627 706191003988 putative binding surface; other site 706191003989 active site 706191003990 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 706191003991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191003992 active site 706191003993 phosphorylation site [posttranslational modification] 706191003994 intermolecular recognition site; other site 706191003995 dimerization interface [polypeptide binding]; other site 706191003996 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 706191003997 DNA binding residues [nucleotide binding] 706191003998 dimerization interface [polypeptide binding]; other site 706191003999 YbgS-like protein; Region: YbgS; pfam13985 706191004000 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 706191004001 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 706191004002 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 706191004003 catalytic core [active] 706191004004 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 706191004005 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 706191004006 active site 706191004007 catalytic residues [active] 706191004008 galactokinase; Provisional; Region: PRK05101 706191004009 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 706191004010 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 706191004011 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 706191004012 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 706191004013 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 706191004014 dimer interface [polypeptide binding]; other site 706191004015 active site 706191004016 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 706191004017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191004018 Walker A/P-loop; other site 706191004019 ATP binding site [chemical binding]; other site 706191004020 Q-loop/lid; other site 706191004021 ABC transporter signature motif; other site 706191004022 Walker B; other site 706191004023 D-loop; other site 706191004024 H-loop/switch region; other site 706191004025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191004026 Walker A/P-loop; other site 706191004027 ATP binding site [chemical binding]; other site 706191004028 Q-loop/lid; other site 706191004029 ABC transporter signature motif; other site 706191004030 Walker B; other site 706191004031 D-loop; other site 706191004032 H-loop/switch region; other site 706191004033 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 706191004034 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 706191004035 molybdenum-pterin binding domain; Region: Mop; TIGR00638 706191004036 TOBE domain; Region: TOBE; cl01440 706191004037 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 706191004038 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 706191004039 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 706191004040 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 706191004041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191004042 dimer interface [polypeptide binding]; other site 706191004043 conserved gate region; other site 706191004044 putative PBP binding loops; other site 706191004045 ABC-ATPase subunit interface; other site 706191004046 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 706191004047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191004048 Walker A/P-loop; other site 706191004049 ATP binding site [chemical binding]; other site 706191004050 Q-loop/lid; other site 706191004051 ABC transporter signature motif; other site 706191004052 Walker B; other site 706191004053 D-loop; other site 706191004054 H-loop/switch region; other site 706191004055 molybdenum-pterin binding domain; Region: Mop; TIGR00638 706191004056 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 706191004057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191004058 active site 706191004059 motif I; other site 706191004060 motif II; other site 706191004061 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 706191004062 6-phosphogluconolactonase; Provisional; Region: PRK11028 706191004063 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 706191004064 substrate binding site [chemical binding]; other site 706191004065 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 706191004066 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 706191004067 inhibitor-cofactor binding pocket; inhibition site 706191004068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191004069 catalytic residue [active] 706191004070 biotin synthase; Provisional; Region: PRK15108 706191004071 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706191004072 FeS/SAM binding site; other site 706191004073 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 706191004074 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 706191004075 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 706191004076 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 706191004077 catalytic residue [active] 706191004078 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 706191004079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191004080 S-adenosylmethionine binding site [chemical binding]; other site 706191004081 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 706191004082 AAA domain; Region: AAA_26; pfam13500 706191004083 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 706191004084 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 706191004085 Walker A/P-loop; other site 706191004086 ATP binding site [chemical binding]; other site 706191004087 Q-loop/lid; other site 706191004088 ABC transporter signature motif; other site 706191004089 Walker B; other site 706191004090 D-loop; other site 706191004091 H-loop/switch region; other site 706191004092 excinuclease ABC subunit B; Provisional; Region: PRK05298 706191004093 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 706191004094 ATP binding site [chemical binding]; other site 706191004095 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 706191004096 nucleotide binding region [chemical binding]; other site 706191004097 ATP-binding site [chemical binding]; other site 706191004098 Ultra-violet resistance protein B; Region: UvrB; pfam12344 706191004099 UvrB/uvrC motif; Region: UVR; pfam02151 706191004100 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 706191004101 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 706191004102 phosphate binding site [ion binding]; other site 706191004103 putative substrate binding pocket [chemical binding]; other site 706191004104 dimer interface [polypeptide binding]; other site 706191004105 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 706191004106 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706191004107 FeS/SAM binding site; other site 706191004108 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 706191004109 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 706191004110 MPT binding site; other site 706191004111 trimer interface [polypeptide binding]; other site 706191004112 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 706191004113 trimer interface [polypeptide binding]; other site 706191004114 dimer interface [polypeptide binding]; other site 706191004115 putative active site [active] 706191004116 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 706191004117 MoaE interaction surface [polypeptide binding]; other site 706191004118 MoeB interaction surface [polypeptide binding]; other site 706191004119 thiocarboxylated glycine; other site 706191004120 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 706191004121 MoaE homodimer interface [polypeptide binding]; other site 706191004122 MoaD interaction [polypeptide binding]; other site 706191004123 active site residues [active] 706191004124 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 706191004125 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 706191004126 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 706191004127 Predicted integral membrane protein [Function unknown]; Region: COG0392 706191004128 cardiolipin synthase 2; Provisional; Region: PRK11263 706191004129 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 706191004130 putative active site [active] 706191004131 catalytic site [active] 706191004132 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 706191004133 putative active site [active] 706191004134 catalytic site [active] 706191004135 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 706191004136 putative catalytic site [active] 706191004137 putative metal binding site [ion binding]; other site 706191004138 putative phosphate binding site [ion binding]; other site 706191004139 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 706191004140 helicase 45; Provisional; Region: PTZ00424 706191004141 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 706191004142 ATP binding site [chemical binding]; other site 706191004143 Mg++ binding site [ion binding]; other site 706191004144 motif III; other site 706191004145 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 706191004146 nucleotide binding region [chemical binding]; other site 706191004147 ATP-binding site [chemical binding]; other site 706191004148 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 706191004149 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 706191004150 FMN binding site [chemical binding]; other site 706191004151 active site 706191004152 catalytic residues [active] 706191004153 substrate binding site [chemical binding]; other site 706191004154 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 706191004155 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 706191004156 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 706191004157 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 706191004158 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 706191004159 Cl binding site [ion binding]; other site 706191004160 oligomer interface [polypeptide binding]; other site 706191004161 L,D-transpeptidase; Provisional; Region: PRK10260 706191004162 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 706191004163 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 706191004164 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 706191004165 oxidoreductase; Provisional; Region: PRK12743 706191004166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706191004167 NAD(P) binding site [chemical binding]; other site 706191004168 active site 706191004169 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 706191004170 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 706191004171 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 706191004172 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 706191004173 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 706191004174 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 706191004175 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 706191004176 Mechanosensitive ion channel; Region: MS_channel; pfam00924 706191004177 D-lactate dehydrogenase; Provisional; Region: PRK11183 706191004178 FAD binding domain; Region: FAD_binding_4; pfam01565 706191004179 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 706191004180 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 706191004181 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 706191004182 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 706191004183 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 706191004184 HAMP domain; Region: HAMP; pfam00672 706191004185 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706191004186 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191004187 dimer interface [polypeptide binding]; other site 706191004188 putative CheW interface [polypeptide binding]; other site 706191004189 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 706191004190 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 706191004191 active site 706191004192 metal binding site [ion binding]; metal-binding site 706191004193 nudix motif; other site 706191004194 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 706191004195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191004196 dimer interface [polypeptide binding]; other site 706191004197 conserved gate region; other site 706191004198 ABC-ATPase subunit interface; other site 706191004199 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 706191004200 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 706191004201 Walker A/P-loop; other site 706191004202 ATP binding site [chemical binding]; other site 706191004203 Q-loop/lid; other site 706191004204 ABC transporter signature motif; other site 706191004205 Walker B; other site 706191004206 D-loop; other site 706191004207 H-loop/switch region; other site 706191004208 CBS domain; Region: CBS; pfam00571 706191004209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191004210 putative PBP binding loops; other site 706191004211 dimer interface [polypeptide binding]; other site 706191004212 ABC-ATPase subunit interface; other site 706191004213 hypothetical protein; Provisional; Region: PRK13681 706191004214 transcriptional regulator MirA; Provisional; Region: PRK15043 706191004215 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 706191004216 DNA binding residues [nucleotide binding] 706191004217 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 706191004218 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706191004219 non-specific DNA binding site [nucleotide binding]; other site 706191004220 salt bridge; other site 706191004221 sequence-specific DNA binding site [nucleotide binding]; other site 706191004222 Cupin domain; Region: Cupin_2; cl17218 706191004223 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191004224 Coenzyme A binding pocket [chemical binding]; other site 706191004225 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 706191004226 DEAD_2; Region: DEAD_2; pfam06733 706191004227 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 706191004228 glycosyl transferase family protein; Provisional; Region: PRK08136 706191004229 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 706191004230 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 706191004231 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 706191004232 metal binding site [ion binding]; metal-binding site 706191004233 putative dimer interface [polypeptide binding]; other site 706191004234 Transcriptional regulators [Transcription]; Region: PurR; COG1609 706191004235 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191004236 DNA binding site [nucleotide binding] 706191004237 domain linker motif; other site 706191004238 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 706191004239 putative dimerization interface [polypeptide binding]; other site 706191004240 putative ligand binding site [chemical binding]; other site 706191004241 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 706191004242 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 706191004243 active site pocket [active] 706191004244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191004245 D-galactonate transporter; Region: 2A0114; TIGR00893 706191004246 putative substrate translocation pore; other site 706191004247 urocanate hydratase; Provisional; Region: PRK05414 706191004248 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 706191004249 active sites [active] 706191004250 tetramer interface [polypeptide binding]; other site 706191004251 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 706191004252 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191004253 DNA-binding site [nucleotide binding]; DNA binding site 706191004254 UTRA domain; Region: UTRA; pfam07702 706191004255 HutD; Region: HutD; pfam05962 706191004256 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 706191004257 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 706191004258 active site 706191004259 imidazolonepropionase; Validated; Region: PRK09356 706191004260 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 706191004261 active site 706191004262 N-formylglutamate amidohydrolase; Region: FGase; cl01522 706191004263 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191004264 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 706191004265 substrate binding pocket [chemical binding]; other site 706191004266 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191004267 membrane-bound complex binding site; other site 706191004268 hinge residues; other site 706191004269 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 706191004270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191004271 dimer interface [polypeptide binding]; other site 706191004272 conserved gate region; other site 706191004273 putative PBP binding loops; other site 706191004274 ABC-ATPase subunit interface; other site 706191004275 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 706191004276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191004277 dimer interface [polypeptide binding]; other site 706191004278 conserved gate region; other site 706191004279 putative PBP binding loops; other site 706191004280 ABC-ATPase subunit interface; other site 706191004281 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 706191004282 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 706191004283 Walker A/P-loop; other site 706191004284 ATP binding site [chemical binding]; other site 706191004285 Q-loop/lid; other site 706191004286 ABC transporter signature motif; other site 706191004287 Walker B; other site 706191004288 D-loop; other site 706191004289 H-loop/switch region; other site 706191004290 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 706191004291 active sites [active] 706191004292 tetramer interface [polypeptide binding]; other site 706191004293 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 706191004294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706191004295 NAD(P) binding site [chemical binding]; other site 706191004296 active site 706191004297 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 706191004298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191004299 S-adenosylmethionine binding site [chemical binding]; other site 706191004300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191004301 Walker B; other site 706191004302 D-loop; other site 706191004303 H-loop/switch region; other site 706191004304 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 706191004305 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 706191004306 dimerization interface [polypeptide binding]; other site 706191004307 DPS ferroxidase diiron center [ion binding]; other site 706191004308 ion pore; other site 706191004309 threonine and homoserine efflux system; Provisional; Region: PRK10532 706191004310 EamA-like transporter family; Region: EamA; pfam00892 706191004311 outer membrane protein X; Provisional; Region: ompX; PRK09408 706191004312 manganese transport regulator MntR; Provisional; Region: PRK11050 706191004313 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 706191004314 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 706191004315 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 706191004316 transmembrane helices; other site 706191004317 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 706191004318 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 706191004319 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706191004320 HlyD family secretion protein; Region: HlyD_3; pfam13437 706191004321 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 706191004322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191004323 putative substrate translocation pore; other site 706191004324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191004325 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 706191004326 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 706191004327 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 706191004328 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 706191004329 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191004330 Walker A/P-loop; other site 706191004331 ATP binding site [chemical binding]; other site 706191004332 Q-loop/lid; other site 706191004333 ABC transporter signature motif; other site 706191004334 Walker B; other site 706191004335 D-loop; other site 706191004336 H-loop/switch region; other site 706191004337 ABC transporter; Region: ABC_tran_2; pfam12848 706191004338 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 706191004339 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 706191004340 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 706191004341 ATP binding site [chemical binding]; other site 706191004342 substrate interface [chemical binding]; other site 706191004343 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 706191004344 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 706191004345 dimer interface [polypeptide binding]; other site 706191004346 putative functional site; other site 706191004347 putative MPT binding site; other site 706191004348 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 706191004349 catalytic nucleophile [active] 706191004350 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 706191004351 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706191004352 Walker A/P-loop; other site 706191004353 ATP binding site [chemical binding]; other site 706191004354 Q-loop/lid; other site 706191004355 ABC transporter signature motif; other site 706191004356 Walker B; other site 706191004357 D-loop; other site 706191004358 H-loop/switch region; other site 706191004359 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 706191004360 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706191004361 Walker A/P-loop; other site 706191004362 ATP binding site [chemical binding]; other site 706191004363 Q-loop/lid; other site 706191004364 ABC transporter signature motif; other site 706191004365 Walker B; other site 706191004366 D-loop; other site 706191004367 H-loop/switch region; other site 706191004368 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 706191004369 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 706191004370 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 706191004371 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 706191004372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191004373 dimer interface [polypeptide binding]; other site 706191004374 conserved gate region; other site 706191004375 putative PBP binding loops; other site 706191004376 ABC-ATPase subunit interface; other site 706191004377 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 706191004378 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 706191004379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191004380 dimer interface [polypeptide binding]; other site 706191004381 conserved gate region; other site 706191004382 putative PBP binding loops; other site 706191004383 ABC-ATPase subunit interface; other site 706191004384 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 706191004385 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 706191004386 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 706191004387 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706191004388 FeS/SAM binding site; other site 706191004389 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 706191004390 active site clefts [active] 706191004391 zinc binding site [ion binding]; other site 706191004392 dimer interface [polypeptide binding]; other site 706191004393 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 706191004394 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 706191004395 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 706191004396 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 706191004397 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 706191004398 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 706191004399 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 706191004400 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 706191004401 active site 706191004402 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 706191004403 putative transporter; Provisional; Region: PRK04972 706191004404 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 706191004405 TrkA-C domain; Region: TrkA_C; pfam02080 706191004406 TrkA-C domain; Region: TrkA_C; pfam02080 706191004407 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 706191004408 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 706191004409 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 706191004410 GSH binding site [chemical binding]; other site 706191004411 catalytic residues [active] 706191004412 Protein of unknown function (DUF1418); Region: DUF1418; cl11648 706191004413 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 706191004414 dimer interface [polypeptide binding]; other site 706191004415 NADPH bind site [chemical binding]; other site 706191004416 FMN binding site [chemical binding]; other site 706191004417 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 706191004418 RimK-like ATP-grasp domain; Region: RimK; pfam08443 706191004419 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 706191004420 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 706191004421 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 706191004422 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 706191004423 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191004424 Walker A/P-loop; other site 706191004425 ATP binding site [chemical binding]; other site 706191004426 Q-loop/lid; other site 706191004427 ABC transporter signature motif; other site 706191004428 Walker B; other site 706191004429 D-loop; other site 706191004430 H-loop/switch region; other site 706191004431 TOBE domain; Region: TOBE_2; pfam08402 706191004432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191004433 dimer interface [polypeptide binding]; other site 706191004434 conserved gate region; other site 706191004435 putative PBP binding loops; other site 706191004436 ABC-ATPase subunit interface; other site 706191004437 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 706191004438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191004439 dimer interface [polypeptide binding]; other site 706191004440 conserved gate region; other site 706191004441 putative PBP binding loops; other site 706191004442 ABC-ATPase subunit interface; other site 706191004443 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 706191004444 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 706191004445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191004446 S-adenosylmethionine binding site [chemical binding]; other site 706191004447 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 706191004448 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191004449 substrate binding pocket [chemical binding]; other site 706191004450 membrane-bound complex binding site; other site 706191004451 hinge residues; other site 706191004452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191004453 dimer interface [polypeptide binding]; other site 706191004454 conserved gate region; other site 706191004455 putative PBP binding loops; other site 706191004456 ABC-ATPase subunit interface; other site 706191004457 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 706191004458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191004459 dimer interface [polypeptide binding]; other site 706191004460 conserved gate region; other site 706191004461 putative PBP binding loops; other site 706191004462 ABC-ATPase subunit interface; other site 706191004463 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 706191004464 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191004465 substrate binding pocket [chemical binding]; other site 706191004466 membrane-bound complex binding site; other site 706191004467 hinge residues; other site 706191004468 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 706191004469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191004470 Walker A/P-loop; other site 706191004471 ATP binding site [chemical binding]; other site 706191004472 Q-loop/lid; other site 706191004473 ABC transporter signature motif; other site 706191004474 Walker B; other site 706191004475 D-loop; other site 706191004476 H-loop/switch region; other site 706191004477 putative lipoprotein; Provisional; Region: PRK10533 706191004478 hypothetical protein; Provisional; Region: PRK02877 706191004479 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 706191004480 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 706191004481 amidase catalytic site [active] 706191004482 Zn binding residues [ion binding]; other site 706191004483 substrate binding site [chemical binding]; other site 706191004484 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 706191004485 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 706191004486 tetramer interface [polypeptide binding]; other site 706191004487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191004488 catalytic residue [active] 706191004489 pyruvate dehydrogenase; Provisional; Region: PRK09124 706191004490 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 706191004491 PYR/PP interface [polypeptide binding]; other site 706191004492 dimer interface [polypeptide binding]; other site 706191004493 tetramer interface [polypeptide binding]; other site 706191004494 TPP binding site [chemical binding]; other site 706191004495 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 706191004496 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 706191004497 TPP-binding site [chemical binding]; other site 706191004498 Predicted membrane protein [Function unknown]; Region: COG2431 706191004499 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 706191004500 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 706191004501 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 706191004502 putative active site [active] 706191004503 putative metal-binding site [ion binding]; other site 706191004504 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 706191004505 DNA-binding site [nucleotide binding]; DNA binding site 706191004506 RNA-binding motif; other site 706191004507 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 706191004508 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 706191004509 Clp amino terminal domain; Region: Clp_N; pfam02861 706191004510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191004511 Walker A motif; other site 706191004512 ATP binding site [chemical binding]; other site 706191004513 Walker B motif; other site 706191004514 arginine finger; other site 706191004515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191004516 Walker A motif; other site 706191004517 ATP binding site [chemical binding]; other site 706191004518 Walker B motif; other site 706191004519 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 706191004520 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 706191004521 rRNA binding site [nucleotide binding]; other site 706191004522 predicted 30S ribosome binding site; other site 706191004523 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 706191004524 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 706191004525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191004526 Walker A/P-loop; other site 706191004527 ATP binding site [chemical binding]; other site 706191004528 Q-loop/lid; other site 706191004529 ABC transporter signature motif; other site 706191004530 Walker B; other site 706191004531 D-loop; other site 706191004532 H-loop/switch region; other site 706191004533 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 706191004534 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 706191004535 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 706191004536 Walker A/P-loop; other site 706191004537 ATP binding site [chemical binding]; other site 706191004538 Q-loop/lid; other site 706191004539 ABC transporter signature motif; other site 706191004540 Walker B; other site 706191004541 D-loop; other site 706191004542 H-loop/switch region; other site 706191004543 thioredoxin reductase; Provisional; Region: PRK10262 706191004544 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706191004545 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706191004546 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 706191004547 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706191004548 putative DNA binding site [nucleotide binding]; other site 706191004549 putative Zn2+ binding site [ion binding]; other site 706191004550 AsnC family; Region: AsnC_trans_reg; pfam01037 706191004551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191004552 DNA translocase FtsK; Provisional; Region: PRK10263 706191004553 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 706191004554 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 706191004555 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 706191004556 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 706191004557 recombination factor protein RarA; Reviewed; Region: PRK13342 706191004558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191004559 Walker A motif; other site 706191004560 ATP binding site [chemical binding]; other site 706191004561 Walker B motif; other site 706191004562 arginine finger; other site 706191004563 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 706191004564 seryl-tRNA synthetase; Provisional; Region: PRK05431 706191004565 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 706191004566 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 706191004567 dimer interface [polypeptide binding]; other site 706191004568 active site 706191004569 motif 1; other site 706191004570 motif 2; other site 706191004571 motif 3; other site 706191004572 putative MFS family transporter protein; Provisional; Region: PRK03633 706191004573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191004574 putative substrate translocation pore; other site 706191004575 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 706191004576 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706191004577 FeS/SAM binding site; other site 706191004578 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 706191004579 Pyruvate formate lyase 1; Region: PFL1; cd01678 706191004580 coenzyme A binding site [chemical binding]; other site 706191004581 active site 706191004582 catalytic residues [active] 706191004583 glycine loop; other site 706191004584 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 706191004585 uncharacterized domain; Region: TIGR00702 706191004586 YcaO-like family; Region: YcaO; pfam02624 706191004587 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 706191004588 homodimer interface [polypeptide binding]; other site 706191004589 substrate-cofactor binding pocket; other site 706191004590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191004591 catalytic residue [active] 706191004592 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 706191004593 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 706191004594 hinge; other site 706191004595 active site 706191004596 cytidylate kinase; Provisional; Region: cmk; PRK00023 706191004597 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 706191004598 CMP-binding site; other site 706191004599 The sites determining sugar specificity; other site 706191004600 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 706191004601 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 706191004602 RNA binding site [nucleotide binding]; other site 706191004603 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 706191004604 RNA binding site [nucleotide binding]; other site 706191004605 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 706191004606 RNA binding site [nucleotide binding]; other site 706191004607 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 706191004608 RNA binding site [nucleotide binding]; other site 706191004609 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 706191004610 RNA binding site [nucleotide binding]; other site 706191004611 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 706191004612 IHF dimer interface [polypeptide binding]; other site 706191004613 IHF - DNA interface [nucleotide binding]; other site 706191004614 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 706191004615 ComEC family competence protein; Provisional; Region: PRK11539 706191004616 Competence protein; Region: Competence; pfam03772 706191004617 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 706191004618 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 706191004619 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 706191004620 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 706191004621 Walker A/P-loop; other site 706191004622 ATP binding site [chemical binding]; other site 706191004623 Q-loop/lid; other site 706191004624 ABC transporter signature motif; other site 706191004625 Walker B; other site 706191004626 D-loop; other site 706191004627 H-loop/switch region; other site 706191004628 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 706191004629 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 706191004630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 706191004631 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 706191004632 Trm112p-like protein; Region: Trm112p; cl01066 706191004633 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 706191004634 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 706191004635 Ligand binding site; other site 706191004636 oligomer interface; other site 706191004637 Uncharacterized conserved protein [Function unknown]; Region: COG1434 706191004638 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 706191004639 putative active site [active] 706191004640 Methyltransferase domain; Region: Methyltransf_23; pfam13489 706191004641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191004642 S-adenosylmethionine binding site [chemical binding]; other site 706191004643 condesin subunit F; Provisional; Region: PRK05260 706191004644 condesin subunit E; Provisional; Region: PRK05256 706191004645 cell division protein MukB; Provisional; Region: mukB; PRK04863 706191004646 P-loop containing region of AAA domain; Region: AAA_29; cl17516 706191004647 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 706191004648 murein L,D-transpeptidase; Provisional; Region: PRK10594 706191004649 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 706191004650 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 706191004651 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 706191004652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 706191004653 Peptidase M15; Region: Peptidase_M15_3; cl01194 706191004654 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 706191004655 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 706191004656 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706191004657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191004658 homodimer interface [polypeptide binding]; other site 706191004659 catalytic residue [active] 706191004660 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 706191004661 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 706191004662 trimer interface [polypeptide binding]; other site 706191004663 eyelet of channel; other site 706191004664 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 706191004665 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 706191004666 putative dimer interface [polypeptide binding]; other site 706191004667 putative anticodon binding site; other site 706191004668 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 706191004669 homodimer interface [polypeptide binding]; other site 706191004670 motif 1; other site 706191004671 motif 2; other site 706191004672 active site 706191004673 motif 3; other site 706191004674 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 706191004675 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 706191004676 active site 706191004677 aminopeptidase N; Provisional; Region: pepN; PRK14015 706191004678 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 706191004679 active site 706191004680 Zn binding site [ion binding]; other site 706191004681 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 706191004682 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 706191004683 Walker A/P-loop; other site 706191004684 ATP binding site [chemical binding]; other site 706191004685 Q-loop/lid; other site 706191004686 ABC transporter signature motif; other site 706191004687 Walker B; other site 706191004688 D-loop; other site 706191004689 H-loop/switch region; other site 706191004690 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 706191004691 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 706191004692 active site 706191004693 dimer interface [polypeptide binding]; other site 706191004694 non-prolyl cis peptide bond; other site 706191004695 insertion regions; other site 706191004696 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 706191004697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191004698 dimer interface [polypeptide binding]; other site 706191004699 conserved gate region; other site 706191004700 putative PBP binding loops; other site 706191004701 ABC-ATPase subunit interface; other site 706191004702 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 706191004703 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191004704 substrate binding pocket [chemical binding]; other site 706191004705 membrane-bound complex binding site; other site 706191004706 hinge residues; other site 706191004707 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 706191004708 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 706191004709 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 706191004710 active site 706191004711 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 706191004712 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 706191004713 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 706191004714 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 706191004715 quinone interaction residues [chemical binding]; other site 706191004716 active site 706191004717 catalytic residues [active] 706191004718 FMN binding site [chemical binding]; other site 706191004719 substrate binding site [chemical binding]; other site 706191004720 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 706191004721 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 706191004722 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 706191004723 MOSC domain; Region: MOSC; pfam03473 706191004724 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706191004725 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 706191004726 catalytic loop [active] 706191004727 iron binding site [ion binding]; other site 706191004728 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 706191004729 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 706191004730 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 706191004731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191004732 S-adenosylmethionine binding site [chemical binding]; other site 706191004733 ABC transporter ATPase component; Reviewed; Region: PRK11147 706191004734 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 706191004735 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191004736 Walker A/P-loop; other site 706191004737 ATP binding site [chemical binding]; other site 706191004738 Q-loop/lid; other site 706191004739 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 706191004740 ABC transporter signature motif; other site 706191004741 Walker B; other site 706191004742 D-loop; other site 706191004743 ABC transporter; Region: ABC_tran_2; pfam12848 706191004744 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 706191004745 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 706191004746 Paraquat-inducible protein A; Region: PqiA; pfam04403 706191004747 Paraquat-inducible protein A; Region: PqiA; pfam04403 706191004748 paraquat-inducible protein B; Provisional; Region: PRK10807 706191004749 mce related protein; Region: MCE; pfam02470 706191004750 mce related protein; Region: MCE; pfam02470 706191004751 mce related protein; Region: MCE; pfam02470 706191004752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 706191004753 Protein of unknown function (DUF330); Region: DUF330; pfam03886 706191004754 Ribosome modulation factor; Region: RMF; pfam04957 706191004755 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 706191004756 active site 1 [active] 706191004757 dimer interface [polypeptide binding]; other site 706191004758 active site 2 [active] 706191004759 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 706191004760 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 706191004761 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 706191004762 outer membrane protein A; Reviewed; Region: PRK10808 706191004763 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 706191004764 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 706191004765 ligand binding site [chemical binding]; other site 706191004766 SOS cell division inhibitor; Provisional; Region: PRK10595 706191004767 TfoX N-terminal domain; Region: TfoX_N; pfam04993 706191004768 TfoX C-terminal domain; Region: TfoX_C; pfam04994 706191004769 TIGR01666 family membrane protein; Region: YCCS 706191004770 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 706191004771 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 706191004772 Predicted membrane protein [Function unknown]; Region: COG3304 706191004773 Domain of unknown function (DUF307); Region: DUF307; pfam03733 706191004774 Domain of unknown function (DUF307); Region: DUF307; pfam03733 706191004775 DNA helicase IV; Provisional; Region: helD; PRK11054 706191004776 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 706191004777 Part of AAA domain; Region: AAA_19; pfam13245 706191004778 Family description; Region: UvrD_C_2; pfam13538 706191004779 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 706191004780 active site 706191004781 dimer interfaces [polypeptide binding]; other site 706191004782 catalytic residues [active] 706191004783 hypothetical protein; Provisional; Region: PRK03641 706191004784 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 706191004785 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 706191004786 heat shock protein HspQ; Provisional; Region: PRK14129 706191004787 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 706191004788 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 706191004789 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 706191004790 putative RNA binding site [nucleotide binding]; other site 706191004791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191004792 S-adenosylmethionine binding site [chemical binding]; other site 706191004793 acylphosphatase; Provisional; Region: PRK14426 706191004794 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 706191004795 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 706191004796 YccA-like proteins; Region: YccA_like; cd10433 706191004797 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 706191004798 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 706191004799 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 706191004800 catalytic core [active] 706191004801 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 706191004802 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 706191004803 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 706191004804 NAD(P) binding site [chemical binding]; other site 706191004805 catalytic residues [active] 706191004806 hypothetical protein; Provisional; Region: PRK10174 706191004807 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 706191004808 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 706191004809 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 706191004810 EamA-like transporter family; Region: EamA; pfam00892 706191004811 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 706191004812 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706191004813 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 706191004814 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 706191004815 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 706191004816 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 706191004817 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 706191004818 Autoinducer binding domain; Region: Autoind_bind; pfam03472 706191004819 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 706191004820 DNA binding residues [nucleotide binding] 706191004821 dimerization interface [polypeptide binding]; other site 706191004822 hypothetical protein; Provisional; Region: PRK10613 706191004823 response regulator; Provisional; Region: PRK09483 706191004824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191004825 active site 706191004826 phosphorylation site [posttranslational modification] 706191004827 intermolecular recognition site; other site 706191004828 dimerization interface [polypeptide binding]; other site 706191004829 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 706191004830 DNA binding residues [nucleotide binding] 706191004831 dimerization interface [polypeptide binding]; other site 706191004832 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 706191004833 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 706191004834 GIY-YIG motif/motif A; other site 706191004835 active site 706191004836 catalytic site [active] 706191004837 putative DNA binding site [nucleotide binding]; other site 706191004838 metal binding site [ion binding]; metal-binding site 706191004839 UvrB/uvrC motif; Region: UVR; pfam02151 706191004840 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 706191004841 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 706191004842 YrhK-like protein; Region: YrhK; pfam14145 706191004843 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 706191004844 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 706191004845 Sulfate transporter family; Region: Sulfate_transp; pfam00916 706191004846 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 706191004847 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 706191004848 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 706191004849 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 706191004850 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 706191004851 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191004852 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 706191004853 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 706191004854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191004855 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 706191004856 putative substrate translocation pore; other site 706191004857 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 706191004858 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706191004859 HlyD family secretion protein; Region: HlyD_3; pfam13437 706191004860 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 706191004861 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 706191004862 PLD-like domain; Region: PLDc_2; pfam13091 706191004863 putative active site [active] 706191004864 catalytic site [active] 706191004865 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 706191004866 PLD-like domain; Region: PLDc_2; pfam13091 706191004867 putative active site [active] 706191004868 catalytic site [active] 706191004869 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 706191004870 Acyltransferase family; Region: Acyl_transf_3; pfam01757 706191004871 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 706191004872 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 706191004873 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 706191004874 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 706191004875 Ligand binding site; other site 706191004876 DXD motif; other site 706191004877 lipoprotein; Provisional; Region: PRK10175 706191004878 secY/secA suppressor protein; Provisional; Region: PRK11467 706191004879 hypothetical protein; Provisional; Region: PRK09272 706191004880 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 706191004881 TetR family transcriptional regulator; Provisional; Region: PRK14996 706191004882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706191004883 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 706191004884 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 706191004885 putative acyl-acceptor binding pocket; other site 706191004886 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 706191004887 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 706191004888 active site residue [active] 706191004889 hypothetical protein; Provisional; Region: PRK03757 706191004890 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 706191004891 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 706191004892 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706191004893 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 706191004894 DNA damage-inducible protein I; Provisional; Region: PRK10597 706191004895 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 706191004896 active site 706191004897 substrate binding pocket [chemical binding]; other site 706191004898 dimer interface [polypeptide binding]; other site 706191004899 lipoprotein; Provisional; Region: PRK10598 706191004900 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 706191004901 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 706191004902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 706191004903 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 706191004904 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 706191004905 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 706191004906 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 706191004907 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 706191004908 Tar ligand binding domain homologue; Region: TarH; pfam02203 706191004909 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706191004910 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191004911 dimer interface [polypeptide binding]; other site 706191004912 putative CheW interface [polypeptide binding]; other site 706191004913 FlgN protein; Region: FlgN; cl09176 706191004914 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 706191004915 SAF-like; Region: SAF_2; pfam13144 706191004916 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 706191004917 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 706191004918 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 706191004919 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 706191004920 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 706191004921 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 706191004922 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 706191004923 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 706191004924 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 706191004925 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 706191004926 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 706191004927 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 706191004928 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 706191004929 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 706191004930 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 706191004931 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 706191004932 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 706191004933 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 706191004934 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 706191004935 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 706191004936 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 706191004937 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 706191004938 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 706191004939 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 706191004940 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 706191004941 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 706191004942 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 706191004943 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 706191004944 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 706191004945 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 706191004946 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 706191004947 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 706191004948 homodimer interface [polypeptide binding]; other site 706191004949 oligonucleotide binding site [chemical binding]; other site 706191004950 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 706191004951 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 706191004952 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 706191004953 RNA binding surface [nucleotide binding]; other site 706191004954 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 706191004955 active site 706191004956 Maf-like protein; Region: Maf; pfam02545 706191004957 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 706191004958 active site 706191004959 dimer interface [polypeptide binding]; other site 706191004960 hypothetical protein; Provisional; Region: PRK11193 706191004961 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 706191004962 putative phosphate acyltransferase; Provisional; Region: PRK05331 706191004963 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 706191004964 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 706191004965 dimer interface [polypeptide binding]; other site 706191004966 active site 706191004967 CoA binding pocket [chemical binding]; other site 706191004968 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 706191004969 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 706191004970 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 706191004971 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 706191004972 NAD(P) binding site [chemical binding]; other site 706191004973 homotetramer interface [polypeptide binding]; other site 706191004974 homodimer interface [polypeptide binding]; other site 706191004975 active site 706191004976 acyl carrier protein; Provisional; Region: acpP; PRK00982 706191004977 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 706191004978 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 706191004979 dimer interface [polypeptide binding]; other site 706191004980 active site 706191004981 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 706191004982 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 706191004983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191004984 catalytic residue [active] 706191004985 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 706191004986 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 706191004987 dimerization interface [polypeptide binding]; other site 706191004988 thymidylate kinase; Validated; Region: tmk; PRK00698 706191004989 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 706191004990 TMP-binding site; other site 706191004991 ATP-binding site [chemical binding]; other site 706191004992 DNA polymerase III subunit delta'; Validated; Region: PRK07993 706191004993 DNA polymerase III subunit delta'; Validated; Region: PRK08485 706191004994 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 706191004995 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 706191004996 active site 706191004997 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 706191004998 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 706191004999 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 706191005000 active site turn [active] 706191005001 phosphorylation site [posttranslational modification] 706191005002 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 706191005003 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706191005004 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191005005 dimer interface [polypeptide binding]; other site 706191005006 putative CheW interface [polypeptide binding]; other site 706191005007 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 706191005008 nucleotide binding site/active site [active] 706191005009 HIT family signature motif; other site 706191005010 catalytic residue [active] 706191005011 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 706191005012 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 706191005013 putative dimer interface [polypeptide binding]; other site 706191005014 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 706191005015 thiamine kinase; Region: ycfN_thiK; TIGR02721 706191005016 active site 706191005017 substrate binding site [chemical binding]; other site 706191005018 ATP binding site [chemical binding]; other site 706191005019 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 706191005020 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 706191005021 beta-hexosaminidase; Provisional; Region: PRK05337 706191005022 hypothetical protein; Provisional; Region: PRK04940 706191005023 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 706191005024 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706191005025 hypothetical protein; Provisional; Region: PRK11280 706191005026 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 706191005027 MarR family; Region: MarR_2; pfam12802 706191005028 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 706191005029 Uncharacterized conserved protein [Function unknown]; Region: COG2128 706191005030 transcription-repair coupling factor; Provisional; Region: PRK10689 706191005031 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 706191005032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 706191005033 ATP binding site [chemical binding]; other site 706191005034 putative Mg++ binding site [ion binding]; other site 706191005035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 706191005036 nucleotide binding region [chemical binding]; other site 706191005037 ATP-binding site [chemical binding]; other site 706191005038 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 706191005039 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 706191005040 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706191005041 FtsX-like permease family; Region: FtsX; pfam02687 706191005042 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 706191005043 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 706191005044 Walker A/P-loop; other site 706191005045 ATP binding site [chemical binding]; other site 706191005046 Q-loop/lid; other site 706191005047 ABC transporter signature motif; other site 706191005048 Walker B; other site 706191005049 D-loop; other site 706191005050 H-loop/switch region; other site 706191005051 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 706191005052 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 706191005053 FtsX-like permease family; Region: FtsX; pfam02687 706191005054 NAD-dependent deacetylase; Provisional; Region: PRK00481 706191005055 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 706191005056 NAD+ binding site [chemical binding]; other site 706191005057 substrate binding site [chemical binding]; other site 706191005058 Zn binding site [ion binding]; other site 706191005059 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 706191005060 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 706191005061 metal binding site [ion binding]; metal-binding site 706191005062 dimer interface [polypeptide binding]; other site 706191005063 Uncharacterized conserved protein [Function unknown]; Region: COG2850 706191005064 Cupin-like domain; Region: Cupin_8; pfam13621 706191005065 sensor protein PhoQ; Provisional; Region: PRK10815 706191005066 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 706191005067 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706191005068 dimer interface [polypeptide binding]; other site 706191005069 phosphorylation site [posttranslational modification] 706191005070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191005071 ATP binding site [chemical binding]; other site 706191005072 Mg2+ binding site [ion binding]; other site 706191005073 G-X-G motif; other site 706191005074 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 706191005075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191005076 active site 706191005077 phosphorylation site [posttranslational modification] 706191005078 intermolecular recognition site; other site 706191005079 dimerization interface [polypeptide binding]; other site 706191005080 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706191005081 DNA binding site [nucleotide binding] 706191005082 adenylosuccinate lyase; Provisional; Region: PRK09285 706191005083 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 706191005084 tetramer interface [polypeptide binding]; other site 706191005085 active site 706191005086 putative lysogenization regulator; Reviewed; Region: PRK00218 706191005087 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 706191005088 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 706191005089 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 706191005090 nudix motif; other site 706191005091 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 706191005092 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 706191005093 active site 706191005094 isocitrate dehydrogenase; Validated; Region: PRK07362 706191005095 isocitrate dehydrogenase; Reviewed; Region: PRK07006 706191005096 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 706191005097 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 706191005098 putative active site [active] 706191005099 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 706191005100 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 706191005101 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 706191005102 putative fimbrial usher protein StbD; Provisional; Region: PRK15247 706191005103 fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248 706191005104 PapC N-terminal domain; Region: PapC_N; pfam13954 706191005105 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 706191005106 PapC C-terminal domain; Region: PapC_C; pfam13953 706191005107 fimbrial chaperone protein StbB; Provisional; Region: PRK15249 706191005108 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 706191005109 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 706191005110 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 706191005111 hypothetical protein; Provisional; Region: PRK06185 706191005112 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 706191005113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706191005114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706191005115 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 706191005116 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 706191005117 Protein export membrane protein; Region: SecD_SecF; cl14618 706191005118 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 706191005119 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706191005120 HlyD family secretion protein; Region: HlyD_3; pfam13437 706191005121 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706191005122 nucleoside transporter; Region: 2A0110; TIGR00889 706191005123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191005124 putative substrate translocation pore; other site 706191005125 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 706191005126 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 706191005127 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 706191005128 substrate binding site [chemical binding]; other site 706191005129 ATP binding site [chemical binding]; other site 706191005130 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 706191005131 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191005132 DNA-binding site [nucleotide binding]; DNA binding site 706191005133 UTRA domain; Region: UTRA; pfam07702 706191005134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191005135 metabolite-proton symporter; Region: 2A0106; TIGR00883 706191005136 putative substrate translocation pore; other site 706191005137 CsbD-like; Region: CsbD; pfam05532 706191005138 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191005139 Coenzyme A binding pocket [chemical binding]; other site 706191005140 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 706191005141 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 706191005142 dimer interface [polypeptide binding]; other site 706191005143 catalytic triad [active] 706191005144 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 706191005145 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 706191005146 N-acetyl-D-glucosamine binding site [chemical binding]; other site 706191005147 catalytic residue [active] 706191005148 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 706191005149 MarR family; Region: MarR_2; cl17246 706191005150 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 706191005151 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 706191005152 TPP-binding site [chemical binding]; other site 706191005153 dimer interface [polypeptide binding]; other site 706191005154 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 706191005155 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 706191005156 PYR/PP interface [polypeptide binding]; other site 706191005157 dimer interface [polypeptide binding]; other site 706191005158 TPP binding site [chemical binding]; other site 706191005159 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 706191005160 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 706191005161 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 706191005162 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 706191005163 N- and C-terminal domain interface [polypeptide binding]; other site 706191005164 active site 706191005165 MgATP binding site [chemical binding]; other site 706191005166 catalytic site [active] 706191005167 metal binding site [ion binding]; metal-binding site 706191005168 putative homotetramer interface [polypeptide binding]; other site 706191005169 putative homodimer interface [polypeptide binding]; other site 706191005170 glycerol binding site [chemical binding]; other site 706191005171 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 706191005172 Mechanosensitive ion channel; Region: MS_channel; pfam00924 706191005173 Flagellar regulator YcgR; Region: YcgR; pfam07317 706191005174 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 706191005175 PilZ domain; Region: PilZ; pfam07238 706191005176 hypothetical protein; Provisional; Region: PRK10457 706191005177 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 706191005178 Trehalase; Region: Trehalase; cl17346 706191005179 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 706191005180 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 706191005181 putative ligand binding site [chemical binding]; other site 706191005182 NAD binding site [chemical binding]; other site 706191005183 dimerization interface [polypeptide binding]; other site 706191005184 catalytic site [active] 706191005185 putative hydrolase; Validated; Region: PRK09248 706191005186 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 706191005187 active site 706191005188 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 706191005189 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 706191005190 CoA-transferase family III; Region: CoA_transf_3; pfam02515 706191005191 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 706191005192 EamA-like transporter family; Region: EamA; pfam00892 706191005193 EamA-like transporter family; Region: EamA; pfam00892 706191005194 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 706191005195 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 706191005196 catalytic triad [active] 706191005197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191005198 S-adenosylmethionine binding site [chemical binding]; other site 706191005199 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 706191005200 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 706191005201 NAD(P) binding site [chemical binding]; other site 706191005202 catalytic residues [active] 706191005203 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 706191005204 Cupin; Region: Cupin_1; smart00835 706191005205 Cupin; Region: Cupin_1; smart00835 706191005206 The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain; Region: ASCH; smart01022 706191005207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 706191005208 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 706191005209 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 706191005210 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 706191005211 beta-galactosidase; Region: BGL; TIGR03356 706191005212 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 706191005213 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 706191005214 active site turn [active] 706191005215 phosphorylation site [posttranslational modification] 706191005216 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 706191005217 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 706191005218 HPr interaction site; other site 706191005219 glycerol kinase (GK) interaction site [polypeptide binding]; other site 706191005220 active site 706191005221 phosphorylation site [posttranslational modification] 706191005222 transcriptional antiterminator BglG; Provisional; Region: PRK09772 706191005223 CAT RNA binding domain; Region: CAT_RBD; smart01061 706191005224 PRD domain; Region: PRD; pfam00874 706191005225 PRD domain; Region: PRD; pfam00874 706191005226 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 706191005227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191005228 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 706191005229 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 706191005230 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 706191005231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 706191005232 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 706191005233 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 706191005234 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 706191005235 FMN binding site [chemical binding]; other site 706191005236 active site 706191005237 substrate binding site [chemical binding]; other site 706191005238 catalytic residue [active] 706191005239 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706191005240 dimerization interface [polypeptide binding]; other site 706191005241 putative DNA binding site [nucleotide binding]; other site 706191005242 putative Zn2+ binding site [ion binding]; other site 706191005243 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191005244 Coenzyme A binding pocket [chemical binding]; other site 706191005245 N-acetyltransferase; Region: Acetyltransf_2; cl00949 706191005246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191005247 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706191005248 putative substrate translocation pore; other site 706191005249 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 706191005250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 706191005251 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 706191005252 putative sialic acid transporter; Region: 2A0112; TIGR00891 706191005253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191005254 putative substrate translocation pore; other site 706191005255 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 706191005256 Amidohydrolase; Region: Amidohydro_2; pfam04909 706191005257 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 706191005258 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 706191005259 conserved cys residue [active] 706191005260 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 706191005261 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 706191005262 inhibitor site; inhibition site 706191005263 active site 706191005264 dimer interface [polypeptide binding]; other site 706191005265 catalytic residue [active] 706191005266 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 706191005267 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 706191005268 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 706191005269 N-terminal plug; other site 706191005270 ligand-binding site [chemical binding]; other site 706191005271 Cupin domain; Region: Cupin_2; pfam07883 706191005272 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 706191005273 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191005274 Dehydratase family; Region: ILVD_EDD; cl00340 706191005275 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 706191005276 Amidase; Region: Amidase; pfam01425 706191005277 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706191005278 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706191005279 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 706191005280 HAMP domain; Region: HAMP; pfam00672 706191005281 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191005282 dimer interface [polypeptide binding]; other site 706191005283 putative CheW interface [polypeptide binding]; other site 706191005284 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 706191005285 active site 706191005286 DNA binding site [nucleotide binding] 706191005287 Int/Topo IB signature motif; other site 706191005288 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 706191005289 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191005290 Coenzyme A binding pocket [chemical binding]; other site 706191005291 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 706191005292 short chain dehydrogenase; Provisional; Region: PRK06180 706191005293 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 706191005294 NADP binding site [chemical binding]; other site 706191005295 active site 706191005296 steroid binding site; other site 706191005297 short chain dehydrogenase; Provisional; Region: PRK06172 706191005298 classical (c) SDRs; Region: SDR_c; cd05233 706191005299 NAD(P) binding site [chemical binding]; other site 706191005300 active site 706191005301 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 706191005302 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 706191005303 FMN binding site [chemical binding]; other site 706191005304 active site 706191005305 substrate binding site [chemical binding]; other site 706191005306 catalytic residue [active] 706191005307 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191005308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191005309 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 706191005310 dimerization interface [polypeptide binding]; other site 706191005311 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 706191005312 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 706191005313 active site 706191005314 metal binding site [ion binding]; metal-binding site 706191005315 YceI-like domain; Region: YceI; pfam04264 706191005316 RNA polymerase sigma factor; Provisional; Region: PRK12511 706191005317 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706191005318 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 706191005319 DNA binding residues [nucleotide binding] 706191005320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706191005321 binding surface 706191005322 TPR motif; other site 706191005323 Tetratricopeptide repeat; Region: TPR_16; pfam13432 706191005324 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 706191005325 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 706191005326 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 706191005327 dimerization interface [polypeptide binding]; other site 706191005328 NAD binding site [chemical binding]; other site 706191005329 ligand binding site [chemical binding]; other site 706191005330 catalytic site [active] 706191005331 Ectoine synthase; Region: Ectoine_synth; cl17598 706191005332 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 706191005333 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 706191005334 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 706191005335 catalytic motif [active] 706191005336 Zn binding site [ion binding]; other site 706191005337 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 706191005338 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 706191005339 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 706191005340 active site 706191005341 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 706191005342 methionine synthase; Provisional; Region: PRK01207 706191005343 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 706191005344 substrate binding site [chemical binding]; other site 706191005345 THF binding site; other site 706191005346 zinc-binding site [ion binding]; other site 706191005347 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 706191005348 catalytic residues [active] 706191005349 dimer interface [polypeptide binding]; other site 706191005350 MarR family; Region: MarR_2; cl17246 706191005351 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 706191005352 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 706191005353 Flavoprotein; Region: Flavoprotein; pfam02441 706191005354 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 706191005355 major facilitator superfamily transporter; Provisional; Region: PRK05122 706191005356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191005357 putative substrate translocation pore; other site 706191005358 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 706191005359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191005360 putative substrate translocation pore; other site 706191005361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191005362 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 706191005363 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 706191005364 Metal-binding active site; metal-binding site 706191005365 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 706191005366 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 706191005367 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 706191005368 FIST N domain; Region: FIST; smart00897 706191005369 FIST C domain; Region: FIST_C; pfam10442 706191005370 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191005371 dimer interface [polypeptide binding]; other site 706191005372 putative CheW interface [polypeptide binding]; other site 706191005373 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 706191005374 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 706191005375 active site 706191005376 homotetramer interface [polypeptide binding]; other site 706191005377 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191005378 Coenzyme A binding pocket [chemical binding]; other site 706191005379 Ykok leader or M-box Mg2+-sensing RNA; PANA_ncRNA26 706191005380 FOG: CBS domain [General function prediction only]; Region: COG0517 706191005381 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 706191005382 Divalent cation transporter; Region: MgtE; pfam01769 706191005383 GTP-binding protein YchF; Reviewed; Region: PRK09601 706191005384 YchF GTPase; Region: YchF; cd01900 706191005385 G1 box; other site 706191005386 GTP/Mg2+ binding site [chemical binding]; other site 706191005387 Switch I region; other site 706191005388 G2 box; other site 706191005389 Switch II region; other site 706191005390 G3 box; other site 706191005391 G4 box; other site 706191005392 G5 box; other site 706191005393 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 706191005394 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 706191005395 putative active site [active] 706191005396 catalytic residue [active] 706191005397 hypothetical protein; Provisional; Region: PRK10692 706191005398 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 706191005399 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706191005400 metal binding site [ion binding]; metal-binding site 706191005401 active site 706191005402 I-site; other site 706191005403 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 706191005404 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 706191005405 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 706191005406 active site 706191005407 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 706191005408 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 706191005409 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 706191005410 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 706191005411 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 706191005412 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 706191005413 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 706191005414 tRNA; other site 706191005415 putative tRNA binding site [nucleotide binding]; other site 706191005416 putative NADP binding site [chemical binding]; other site 706191005417 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 706191005418 peptide chain release factor 1; Validated; Region: prfA; PRK00591 706191005419 This domain is found in peptide chain release factors; Region: PCRF; smart00937 706191005420 RF-1 domain; Region: RF-1; pfam00472 706191005421 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 706191005422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191005423 S-adenosylmethionine binding site [chemical binding]; other site 706191005424 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 706191005425 hypothetical protein; Provisional; Region: PRK10941 706191005426 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 706191005427 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 706191005428 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 706191005429 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 706191005430 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 706191005431 cation transport regulator; Reviewed; Region: chaB; PRK09582 706191005432 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 706191005433 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 706191005434 putative active site pocket [active] 706191005435 dimerization interface [polypeptide binding]; other site 706191005436 putative catalytic residue [active] 706191005437 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 706191005438 Catalytic domain of Protein Kinases; Region: PKc; cd00180 706191005439 active site 706191005440 ATP binding site [chemical binding]; other site 706191005441 substrate binding site [chemical binding]; other site 706191005442 activation loop (A-loop); other site 706191005443 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 706191005444 active site 706191005445 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 706191005446 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 706191005447 phosphopeptide binding site; other site 706191005448 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 706191005449 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 706191005450 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 706191005451 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 706191005452 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 706191005453 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 706191005454 ligand binding site [chemical binding]; other site 706191005455 Nitrate and nitrite sensing; Region: NIT; pfam08376 706191005456 ANTAR domain; Region: ANTAR; pfam03861 706191005457 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 706191005458 NMT1-like family; Region: NMT1_2; pfam13379 706191005459 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 706191005460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191005461 dimer interface [polypeptide binding]; other site 706191005462 conserved gate region; other site 706191005463 putative PBP binding loops; other site 706191005464 ABC-ATPase subunit interface; other site 706191005465 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 706191005466 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 706191005467 Walker A/P-loop; other site 706191005468 ATP binding site [chemical binding]; other site 706191005469 Q-loop/lid; other site 706191005470 ABC transporter signature motif; other site 706191005471 Walker B; other site 706191005472 D-loop; other site 706191005473 H-loop/switch region; other site 706191005474 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 706191005475 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706191005476 nitrite reductase subunit NirD; Provisional; Region: PRK14989 706191005477 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706191005478 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 706191005479 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 706191005480 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 706191005481 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 706191005482 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 706191005483 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 706191005484 [4Fe-4S] binding site [ion binding]; other site 706191005485 molybdopterin cofactor binding site; other site 706191005486 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 706191005487 molybdopterin cofactor binding site; other site 706191005488 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 706191005489 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 706191005490 active site 706191005491 SAM binding site [chemical binding]; other site 706191005492 homodimer interface [polypeptide binding]; other site 706191005493 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 706191005494 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 706191005495 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 706191005496 short chain dehydrogenase; Provisional; Region: PRK06841 706191005497 classical (c) SDRs; Region: SDR_c; cd05233 706191005498 NAD(P) binding site [chemical binding]; other site 706191005499 active site 706191005500 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 706191005501 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706191005502 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 706191005503 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 706191005504 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 706191005505 Walker A/P-loop; other site 706191005506 ATP binding site [chemical binding]; other site 706191005507 Q-loop/lid; other site 706191005508 ABC transporter signature motif; other site 706191005509 Walker B; other site 706191005510 D-loop; other site 706191005511 H-loop/switch region; other site 706191005512 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 706191005513 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 706191005514 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706191005515 TM-ABC transporter signature motif; other site 706191005516 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 706191005517 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706191005518 NAD(P) binding site [chemical binding]; other site 706191005519 active site 706191005520 putative invasin; Provisional; Region: PRK10177 706191005521 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 706191005522 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 706191005523 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 706191005524 trimer interface [polypeptide binding]; other site 706191005525 eyelet of channel; other site 706191005526 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 706191005527 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 706191005528 inhibitor-cofactor binding pocket; inhibition site 706191005529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191005530 catalytic residue [active] 706191005531 arginine succinyltransferase; Provisional; Region: PRK10456 706191005532 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 706191005533 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 706191005534 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 706191005535 NAD(P) binding site [chemical binding]; other site 706191005536 catalytic residues [active] 706191005537 succinylarginine dihydrolase; Provisional; Region: PRK13281 706191005538 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 706191005539 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 706191005540 putative active site [active] 706191005541 Zn binding site [ion binding]; other site 706191005542 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 706191005543 dimer interface [polypeptide binding]; other site 706191005544 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 706191005545 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 706191005546 GIY-YIG motif/motif A; other site 706191005547 active site 706191005548 catalytic site [active] 706191005549 putative DNA binding site [nucleotide binding]; other site 706191005550 metal binding site [ion binding]; metal-binding site 706191005551 aromatic amino acid exporter; Provisional; Region: PRK11689 706191005552 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 706191005553 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706191005554 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191005555 dimer interface [polypeptide binding]; other site 706191005556 putative CheW interface [polypeptide binding]; other site 706191005557 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 706191005558 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 706191005559 homodimer interface [polypeptide binding]; other site 706191005560 NAD binding pocket [chemical binding]; other site 706191005561 ATP binding pocket [chemical binding]; other site 706191005562 Mg binding site [ion binding]; other site 706191005563 active-site loop [active] 706191005564 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 706191005565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191005566 putative substrate translocation pore; other site 706191005567 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 706191005568 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 706191005569 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 706191005570 inner membrane protein; Provisional; Region: PRK11648 706191005571 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 706191005572 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 706191005573 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191005574 motif II; other site 706191005575 YniB-like protein; Region: YniB; pfam14002 706191005576 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 706191005577 Phosphotransferase enzyme family; Region: APH; pfam01636 706191005578 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 706191005579 Protein of unknown function, DUF481; Region: DUF481; cl01213 706191005580 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 706191005581 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 706191005582 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 706191005583 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 706191005584 active site 706191005585 dimer interface [polypeptide binding]; other site 706191005586 motif 1; other site 706191005587 motif 2; other site 706191005588 motif 3; other site 706191005589 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 706191005590 anticodon binding site; other site 706191005591 translation initiation factor IF-3; Region: infC; TIGR00168 706191005592 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 706191005593 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 706191005594 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 706191005595 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 706191005596 23S rRNA binding site [nucleotide binding]; other site 706191005597 L21 binding site [polypeptide binding]; other site 706191005598 L13 binding site [polypeptide binding]; other site 706191005599 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 706191005600 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 706191005601 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 706191005602 dimer interface [polypeptide binding]; other site 706191005603 motif 1; other site 706191005604 active site 706191005605 motif 2; other site 706191005606 motif 3; other site 706191005607 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 706191005608 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 706191005609 putative tRNA-binding site [nucleotide binding]; other site 706191005610 B3/4 domain; Region: B3_4; pfam03483 706191005611 tRNA synthetase B5 domain; Region: B5; smart00874 706191005612 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 706191005613 dimer interface [polypeptide binding]; other site 706191005614 motif 1; other site 706191005615 motif 3; other site 706191005616 motif 2; other site 706191005617 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 706191005618 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 706191005619 IHF dimer interface [polypeptide binding]; other site 706191005620 IHF - DNA interface [nucleotide binding]; other site 706191005621 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 706191005622 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 706191005623 ABC-ATPase subunit interface; other site 706191005624 dimer interface [polypeptide binding]; other site 706191005625 putative PBP binding regions; other site 706191005626 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 706191005627 catalytic residues [active] 706191005628 dimer interface [polypeptide binding]; other site 706191005629 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 706191005630 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 706191005631 Walker A/P-loop; other site 706191005632 ATP binding site [chemical binding]; other site 706191005633 Q-loop/lid; other site 706191005634 ABC transporter signature motif; other site 706191005635 Walker B; other site 706191005636 D-loop; other site 706191005637 H-loop/switch region; other site 706191005638 NlpC/P60 family; Region: NLPC_P60; pfam00877 706191005639 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 706191005640 Uncharacterized conserved protein [Function unknown]; Region: COG0397 706191005641 hypothetical protein; Validated; Region: PRK00029 706191005642 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 706191005643 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 706191005644 PEP synthetase regulatory protein; Provisional; Region: PRK05339 706191005645 phosphoenolpyruvate synthase; Validated; Region: PRK06464 706191005646 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 706191005647 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 706191005648 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 706191005649 putative inner membrane protein; Provisional; Region: PRK10983 706191005650 Domain of unknown function DUF20; Region: UPF0118; pfam01594 706191005651 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 706191005652 FAD binding domain; Region: FAD_binding_4; pfam01565 706191005653 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 706191005654 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 706191005655 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 706191005656 putative ABC transporter; Region: ycf24; CHL00085 706191005657 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 706191005658 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 706191005659 Walker A/P-loop; other site 706191005660 ATP binding site [chemical binding]; other site 706191005661 Q-loop/lid; other site 706191005662 ABC transporter signature motif; other site 706191005663 Walker B; other site 706191005664 D-loop; other site 706191005665 H-loop/switch region; other site 706191005666 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 706191005667 FeS assembly protein SufD; Region: sufD; TIGR01981 706191005668 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 706191005669 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 706191005670 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 706191005671 catalytic residue [active] 706191005672 cysteine desufuration protein SufE; Provisional; Region: PRK09296 706191005673 L,D-transpeptidase; Provisional; Region: PRK10190 706191005674 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 706191005675 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 706191005676 murein lipoprotein; Provisional; Region: PRK15396 706191005677 pyruvate kinase; Provisional; Region: PRK09206 706191005678 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 706191005679 domain interfaces; other site 706191005680 active site 706191005681 multidrug efflux protein; Reviewed; Region: PRK01766 706191005682 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 706191005683 cation binding site [ion binding]; other site 706191005684 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 706191005685 Lumazine binding domain; Region: Lum_binding; pfam00677 706191005686 Lumazine binding domain; Region: Lum_binding; pfam00677 706191005687 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 706191005688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191005689 S-adenosylmethionine binding site [chemical binding]; other site 706191005690 putative transporter; Provisional; Region: PRK11043 706191005691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191005692 putative substrate translocation pore; other site 706191005693 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 706191005694 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191005695 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 706191005696 dimerization interface [polypeptide binding]; other site 706191005697 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 706191005698 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191005699 DNA binding site [nucleotide binding] 706191005700 domain linker motif; other site 706191005701 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 706191005702 dimerization interface [polypeptide binding]; other site 706191005703 ligand binding site [chemical binding]; other site 706191005704 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 706191005705 NlpC/P60 family; Region: NLPC_P60; pfam00877 706191005706 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 706191005707 putative GSH binding site [chemical binding]; other site 706191005708 catalytic residues [active] 706191005709 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 706191005710 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 706191005711 dimer interface [polypeptide binding]; other site 706191005712 catalytic site [active] 706191005713 putative active site [active] 706191005714 putative substrate binding site [chemical binding]; other site 706191005715 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 706191005716 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 706191005717 dimer interface [polypeptide binding]; other site 706191005718 active site 706191005719 metal binding site [ion binding]; metal-binding site 706191005720 glutathione binding site [chemical binding]; other site 706191005721 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 706191005722 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 706191005723 FMN binding site [chemical binding]; other site 706191005724 active site 706191005725 substrate binding site [chemical binding]; other site 706191005726 catalytic residue [active] 706191005727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706191005728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706191005729 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 706191005730 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 706191005731 active site 706191005732 catalytic tetrad [active] 706191005733 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 706191005734 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 706191005735 E-class dimer interface [polypeptide binding]; other site 706191005736 P-class dimer interface [polypeptide binding]; other site 706191005737 active site 706191005738 Cu2+ binding site [ion binding]; other site 706191005739 Zn2+ binding site [ion binding]; other site 706191005740 Fusaric acid resistance protein family; Region: FUSC; pfam04632 706191005741 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 706191005742 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 706191005743 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706191005744 HlyD family secretion protein; Region: HlyD_3; pfam13437 706191005745 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 706191005746 transcriptional regulator SlyA; Provisional; Region: PRK03573 706191005747 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 706191005748 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 706191005749 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 706191005750 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 706191005751 Sensors of blue-light using FAD; Region: BLUF; pfam04940 706191005752 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 706191005753 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 706191005754 classical (c) SDRs; Region: SDR_c; cd05233 706191005755 NAD(P) binding site [chemical binding]; other site 706191005756 active site 706191005757 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 706191005758 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 706191005759 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 706191005760 active site 706191005761 catalytic site [active] 706191005762 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 706191005763 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 706191005764 active site 706191005765 catalytic site [active] 706191005766 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 706191005767 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 706191005768 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 706191005769 catalytic site [active] 706191005770 active site 706191005771 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 706191005772 hydroperoxidase II; Provisional; Region: katE; PRK11249 706191005773 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 706191005774 tetramer interface [polypeptide binding]; other site 706191005775 heme binding pocket [chemical binding]; other site 706191005776 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 706191005777 domain interactions; other site 706191005778 UV-endonuclease UvdE; Region: UvdE; cl10036 706191005779 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 706191005780 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 706191005781 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 706191005782 conserved cys residue [active] 706191005783 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 706191005784 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 706191005785 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191005786 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 706191005787 dimerization interface [polypeptide binding]; other site 706191005788 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 706191005789 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 706191005790 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 706191005791 Catalytic site [active] 706191005792 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 706191005793 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 706191005794 active site 706191005795 DNA binding site [nucleotide binding] 706191005796 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 706191005797 chaperone protein HchA; Provisional; Region: PRK04155 706191005798 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 706191005799 conserved cys residue [active] 706191005800 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706191005801 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706191005802 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 706191005803 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 706191005804 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 706191005805 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 706191005806 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 706191005807 active site 706191005808 homotetramer interface [polypeptide binding]; other site 706191005809 lysozyme inhibitor; Provisional; Region: PRK11372 706191005810 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 706191005811 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 706191005812 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 706191005813 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 706191005814 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 706191005815 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 706191005816 active site 706191005817 HIGH motif; other site 706191005818 dimer interface [polypeptide binding]; other site 706191005819 KMSKS motif; other site 706191005820 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 706191005821 RNA binding surface [nucleotide binding]; other site 706191005822 pyridoxamine kinase; Validated; Region: PRK05756 706191005823 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 706191005824 dimer interface [polypeptide binding]; other site 706191005825 pyridoxal binding site [chemical binding]; other site 706191005826 ATP binding site [chemical binding]; other site 706191005827 glutathionine S-transferase; Provisional; Region: PRK10542 706191005828 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 706191005829 C-terminal domain interface [polypeptide binding]; other site 706191005830 GSH binding site (G-site) [chemical binding]; other site 706191005831 dimer interface [polypeptide binding]; other site 706191005832 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 706191005833 dimer interface [polypeptide binding]; other site 706191005834 N-terminal domain interface [polypeptide binding]; other site 706191005835 substrate binding pocket (H-site) [chemical binding]; other site 706191005836 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 706191005837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191005838 putative substrate translocation pore; other site 706191005839 hypothetical protein; Validated; Region: PRK06186 706191005840 conserved cys residue [active] 706191005841 endonuclease III; Provisional; Region: PRK10702 706191005842 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 706191005843 minor groove reading motif; other site 706191005844 helix-hairpin-helix signature motif; other site 706191005845 substrate binding pocket [chemical binding]; other site 706191005846 active site 706191005847 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 706191005848 electron transport complex RsxE subunit; Provisional; Region: PRK12405 706191005849 electron transport complex protein RnfG; Validated; Region: PRK01908 706191005850 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 706191005851 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 706191005852 SLBB domain; Region: SLBB; pfam10531 706191005853 ferredoxin; Provisional; Region: PRK06991 706191005854 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 706191005855 electron transport complex protein RnfB; Provisional; Region: PRK05113 706191005856 Putative Fe-S cluster; Region: FeS; cl17515 706191005857 4Fe-4S binding domain; Region: Fer4; pfam00037 706191005858 electron transport complex protein RsxA; Provisional; Region: PRK05151 706191005859 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 706191005860 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 706191005861 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 706191005862 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 706191005863 putative ligand binding site [chemical binding]; other site 706191005864 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 706191005865 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 706191005866 Walker A/P-loop; other site 706191005867 ATP binding site [chemical binding]; other site 706191005868 Q-loop/lid; other site 706191005869 ABC transporter signature motif; other site 706191005870 Walker B; other site 706191005871 D-loop; other site 706191005872 H-loop/switch region; other site 706191005873 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 706191005874 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706191005875 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 706191005876 TM-ABC transporter signature motif; other site 706191005877 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706191005878 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 706191005879 TM-ABC transporter signature motif; other site 706191005880 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 706191005881 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706191005882 metal binding site [ion binding]; metal-binding site 706191005883 active site 706191005884 I-site; other site 706191005885 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 706191005886 DNA binding site [nucleotide binding] 706191005887 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 706191005888 PapC N-terminal domain; Region: PapC_N; pfam13954 706191005889 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 706191005890 putative fimbrial chaperone protein; Provisional; Region: PRK09918 706191005891 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 706191005892 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 706191005893 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 706191005894 DNA binding residues [nucleotide binding] 706191005895 dimerization interface [polypeptide binding]; other site 706191005896 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 706191005897 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 706191005898 DNA binding residues [nucleotide binding] 706191005899 dimerization interface [polypeptide binding]; other site 706191005900 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 706191005901 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 706191005902 amidase catalytic site [active] 706191005903 Zn binding residues [ion binding]; other site 706191005904 substrate binding site [chemical binding]; other site 706191005905 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 706191005906 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 706191005907 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 706191005908 Na binding site [ion binding]; other site 706191005909 Cupin; Region: Cupin_6; pfam12852 706191005910 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191005911 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 706191005912 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191005913 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 706191005914 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 706191005915 putative NAD(P) binding site [chemical binding]; other site 706191005916 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 706191005917 Mechanosensitive ion channel; Region: MS_channel; pfam00924 706191005918 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 706191005919 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 706191005920 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 706191005921 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 706191005922 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 706191005923 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706191005924 putative DNA binding site [nucleotide binding]; other site 706191005925 putative Zn2+ binding site [ion binding]; other site 706191005926 AsnC family; Region: AsnC_trans_reg; pfam01037 706191005927 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 706191005928 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 706191005929 inhibitor-cofactor binding pocket; inhibition site 706191005930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191005931 catalytic residue [active] 706191005932 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 706191005933 active site 706191005934 ATP binding site [chemical binding]; other site 706191005935 substrate binding site [chemical binding]; other site 706191005936 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 706191005937 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191005938 motif II; other site 706191005939 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 706191005940 DNA-binding site [nucleotide binding]; DNA binding site 706191005941 RNA-binding motif; other site 706191005942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 706191005943 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 706191005944 CGNR zinc finger; Region: zf-CGNR; pfam11706 706191005945 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 706191005946 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 706191005947 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 706191005948 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 706191005949 active site 706191005950 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191005951 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191005952 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 706191005953 putative substrate binding pocket [chemical binding]; other site 706191005954 putative dimerization interface [polypeptide binding]; other site 706191005955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706191005956 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 706191005957 NAD(P) binding site [chemical binding]; other site 706191005958 active site 706191005959 L-arabinose isomerase; Provisional; Region: PRK02929 706191005960 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 706191005961 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 706191005962 trimer interface [polypeptide binding]; other site 706191005963 putative substrate binding site [chemical binding]; other site 706191005964 putative metal binding site [ion binding]; other site 706191005965 ribulokinase; Provisional; Region: PRK04123 706191005966 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 706191005967 N- and C-terminal domain interface [polypeptide binding]; other site 706191005968 active site 706191005969 MgATP binding site [chemical binding]; other site 706191005970 catalytic site [active] 706191005971 metal binding site [ion binding]; metal-binding site 706191005972 carbohydrate binding site [chemical binding]; other site 706191005973 homodimer interface [polypeptide binding]; other site 706191005974 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 706191005975 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 706191005976 ligand binding site [chemical binding]; other site 706191005977 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 706191005978 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 706191005979 Walker A/P-loop; other site 706191005980 ATP binding site [chemical binding]; other site 706191005981 Q-loop/lid; other site 706191005982 ABC transporter signature motif; other site 706191005983 Walker B; other site 706191005984 D-loop; other site 706191005985 H-loop/switch region; other site 706191005986 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 706191005987 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 706191005988 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706191005989 TM-ABC transporter signature motif; other site 706191005990 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 706191005991 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 706191005992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191005993 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191005994 putative oxidoreductase; Provisional; Region: PRK11579 706191005995 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 706191005996 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 706191005997 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 706191005998 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 706191005999 active site 706191006000 purine riboside binding site [chemical binding]; other site 706191006001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 706191006002 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 706191006003 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 706191006004 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 706191006005 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 706191006006 fumarate hydratase; Reviewed; Region: fumC; PRK00485 706191006007 Class II fumarases; Region: Fumarase_classII; cd01362 706191006008 active site 706191006009 tetramer interface [polypeptide binding]; other site 706191006010 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 706191006011 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706191006012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 706191006013 putative substrate translocation pore; other site 706191006014 Transcriptional regulator; Region: Rrf2; pfam02082 706191006015 Predicted transcriptional regulator [Transcription]; Region: COG1959 706191006016 Transcriptional regulator; Region: Rrf2; cl17282 706191006017 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 706191006018 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 706191006019 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706191006020 HlyD family secretion protein; Region: HlyD_3; pfam13437 706191006021 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 706191006022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191006023 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 706191006024 active site 706191006025 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 706191006026 RNAase interaction site [polypeptide binding]; other site 706191006027 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfC; COG4458 706191006028 Virulence factor SrfB; Region: SrfB; pfam07520 706191006029 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 706191006030 benzoate transporter; Region: benE; TIGR00843 706191006031 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 706191006032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706191006033 non-specific DNA binding site [nucleotide binding]; other site 706191006034 salt bridge; other site 706191006035 sequence-specific DNA binding site [nucleotide binding]; other site 706191006036 Isochorismatase family; Region: Isochorismatase; pfam00857 706191006037 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 706191006038 catalytic triad [active] 706191006039 conserved cis-peptide bond; other site 706191006040 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 706191006041 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 706191006042 N-terminal plug; other site 706191006043 ligand-binding site [chemical binding]; other site 706191006044 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 706191006045 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 706191006046 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 706191006047 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191006048 2-isopropylmalate synthase; Validated; Region: PRK03739 706191006049 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 706191006050 active site 706191006051 catalytic residues [active] 706191006052 metal binding site [ion binding]; metal-binding site 706191006053 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 706191006054 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 706191006055 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 706191006056 active site 706191006057 dimer interface [polypeptide binding]; other site 706191006058 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 706191006059 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 706191006060 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 706191006061 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 706191006062 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 706191006063 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706191006064 FeS/SAM binding site; other site 706191006065 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 706191006066 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 706191006067 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 706191006068 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 706191006069 Uncharacterized conserved protein [Function unknown]; Region: COG2353 706191006070 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 706191006071 active site 706191006072 ADP/pyrophosphate binding site [chemical binding]; other site 706191006073 dimerization interface [polypeptide binding]; other site 706191006074 allosteric effector site; other site 706191006075 fructose-1,6-bisphosphate binding site; other site 706191006076 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 706191006077 active site 706191006078 P-loop; other site 706191006079 phosphorylation site [posttranslational modification] 706191006080 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 706191006081 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 706191006082 intersubunit interface [polypeptide binding]; other site 706191006083 active site 706191006084 zinc binding site [ion binding]; other site 706191006085 Na+ binding site [ion binding]; other site 706191006086 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 706191006087 active site 706191006088 phosphorylation site [posttranslational modification] 706191006089 AAA domain; Region: AAA_17; pfam13207 706191006090 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 706191006091 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 706191006092 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 706191006093 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 706191006094 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 706191006095 trimer interface [polypeptide binding]; other site 706191006096 active site 706191006097 substrate binding site [chemical binding]; other site 706191006098 CoA binding site [chemical binding]; other site 706191006099 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 706191006100 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 706191006101 tetramer interface [polypeptide binding]; other site 706191006102 heme binding pocket [chemical binding]; other site 706191006103 NADPH binding site [chemical binding]; other site 706191006104 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 706191006105 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 706191006106 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 706191006107 ligand binding site [chemical binding]; other site 706191006108 dimerization interface [polypeptide binding]; other site 706191006109 zinc binding site [ion binding]; other site 706191006110 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 706191006111 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 706191006112 Walker A/P-loop; other site 706191006113 ATP binding site [chemical binding]; other site 706191006114 Q-loop/lid; other site 706191006115 ABC transporter signature motif; other site 706191006116 Walker B; other site 706191006117 D-loop; other site 706191006118 H-loop/switch region; other site 706191006119 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 706191006120 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706191006121 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 706191006122 TM-ABC transporter signature motif; other site 706191006123 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 706191006124 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 706191006125 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 706191006126 putative active site [active] 706191006127 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 706191006128 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 706191006129 substrate binding site [chemical binding]; other site 706191006130 ATP binding site [chemical binding]; other site 706191006131 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 706191006132 Prostaglandin dehydrogenases; Region: PGDH; cd05288 706191006133 NAD(P) binding site [chemical binding]; other site 706191006134 substrate binding site [chemical binding]; other site 706191006135 dimer interface [polypeptide binding]; other site 706191006136 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 706191006137 active site 706191006138 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 706191006139 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 706191006140 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 706191006141 HAMP domain; Region: HAMP; pfam00672 706191006142 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191006143 dimer interface [polypeptide binding]; other site 706191006144 putative CheW interface [polypeptide binding]; other site 706191006145 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 706191006146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191006147 active site 706191006148 intermolecular recognition site; other site 706191006149 dimerization interface [polypeptide binding]; other site 706191006150 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706191006151 DNA binding site [nucleotide binding] 706191006152 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 706191006153 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 706191006154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191006155 Walker A/P-loop; other site 706191006156 ATP binding site [chemical binding]; other site 706191006157 Q-loop/lid; other site 706191006158 ABC transporter signature motif; other site 706191006159 Walker B; other site 706191006160 D-loop; other site 706191006161 H-loop/switch region; other site 706191006162 maltose O-acetyltransferase; Provisional; Region: PRK10092 706191006163 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 706191006164 active site 706191006165 substrate binding site [chemical binding]; other site 706191006166 trimer interface [polypeptide binding]; other site 706191006167 CoA binding site [chemical binding]; other site 706191006168 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 706191006169 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 706191006170 active site 706191006171 metal binding site [ion binding]; metal-binding site 706191006172 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191006173 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191006174 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 706191006175 putative effector binding pocket; other site 706191006176 putative dimerization interface [polypeptide binding]; other site 706191006177 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 706191006178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706191006179 NAD(P) binding site [chemical binding]; other site 706191006180 active site 706191006181 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191006182 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191006183 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_5; cd08426 706191006184 putative dimerization interface [polypeptide binding]; other site 706191006185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 706191006186 hypothetical protein; Provisional; Region: PRK10519 706191006187 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 706191006188 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 706191006189 metal binding site [ion binding]; metal-binding site 706191006190 putative dimer interface [polypeptide binding]; other site 706191006191 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 706191006192 ArsC family; Region: ArsC; pfam03960 706191006193 catalytic residues [active] 706191006194 arsenical pump membrane protein; Provisional; Region: PRK15445 706191006195 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 706191006196 transmembrane helices; other site 706191006197 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706191006198 dimerization interface [polypeptide binding]; other site 706191006199 putative DNA binding site [nucleotide binding]; other site 706191006200 putative Zn2+ binding site [ion binding]; other site 706191006201 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 706191006202 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753 706191006203 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; pfam01036 706191006204 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 706191006205 Xanthomonas XOO_2897-like deaminase; Region: XOO_2897-deam; pfam14440 706191006206 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 706191006207 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 706191006208 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 706191006209 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 706191006210 active site 706191006211 FMN binding site [chemical binding]; other site 706191006212 substrate binding site [chemical binding]; other site 706191006213 homotetramer interface [polypeptide binding]; other site 706191006214 catalytic residue [active] 706191006215 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 706191006216 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 706191006217 Alkaline phosphatase homologues; Region: alkPPc; smart00098 706191006218 active site 706191006219 dimer interface [polypeptide binding]; other site 706191006220 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 706191006221 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706191006222 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 706191006223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191006224 dimer interface [polypeptide binding]; other site 706191006225 conserved gate region; other site 706191006226 putative PBP binding loops; other site 706191006227 ABC-ATPase subunit interface; other site 706191006228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191006229 dimer interface [polypeptide binding]; other site 706191006230 conserved gate region; other site 706191006231 putative PBP binding loops; other site 706191006232 ABC-ATPase subunit interface; other site 706191006233 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 706191006234 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 706191006235 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 706191006236 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 706191006237 Walker A/P-loop; other site 706191006238 ATP binding site [chemical binding]; other site 706191006239 Q-loop/lid; other site 706191006240 ABC transporter signature motif; other site 706191006241 Walker B; other site 706191006242 D-loop; other site 706191006243 H-loop/switch region; other site 706191006244 TOBE domain; Region: TOBE_2; pfam08402 706191006245 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 706191006246 trimer interface; other site 706191006247 sugar binding site [chemical binding]; other site 706191006248 maltose regulon periplasmic protein; Provisional; Region: PRK10564 706191006249 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 706191006250 PGAP1-like protein; Region: PGAP1; pfam07819 706191006251 Helix-turn-helix domain; Region: HTH_18; pfam12833 706191006252 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191006253 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 706191006254 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 706191006255 maltodextrin phosphorylase; Provisional; Region: PRK14985 706191006256 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 706191006257 active site pocket [active] 706191006258 transcriptional regulator MalT; Provisional; Region: PRK04841 706191006259 AAA ATPase domain; Region: AAA_16; pfam13191 706191006260 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 706191006261 DNA binding residues [nucleotide binding] 706191006262 dimerization interface [polypeptide binding]; other site 706191006263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191006264 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706191006265 putative substrate translocation pore; other site 706191006266 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 706191006267 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191006268 Coenzyme A binding pocket [chemical binding]; other site 706191006269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 706191006270 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 706191006271 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 706191006272 putative oxidoreductase; Provisional; Region: PRK09939 706191006273 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 706191006274 putative molybdopterin cofactor binding site [chemical binding]; other site 706191006275 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 706191006276 putative molybdopterin cofactor binding site; other site 706191006277 magnesium transport protein MgtC; Provisional; Region: PRK15385 706191006278 MgtC family; Region: MgtC; pfam02308 706191006279 NlpC/P60 family; Region: NLPC_P60; pfam00877 706191006280 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 706191006281 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 706191006282 active site 706191006283 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 706191006284 nudix motif; other site 706191006285 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 706191006286 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 706191006287 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706191006288 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 706191006289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706191006290 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 706191006291 NAD(P) binding site [chemical binding]; other site 706191006292 active site 706191006293 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 706191006294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706191006295 NAD(P) binding site [chemical binding]; other site 706191006296 active site 706191006297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191006298 benzoate transport; Region: 2A0115; TIGR00895 706191006299 putative substrate translocation pore; other site 706191006300 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 706191006301 active site 706191006302 catalytic site [active] 706191006303 Zn binding site [ion binding]; other site 706191006304 tetramer interface [polypeptide binding]; other site 706191006305 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 706191006306 Amidase; Region: Amidase; cl11426 706191006307 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191006308 DNA-binding site [nucleotide binding]; DNA binding site 706191006309 Transcriptional regulators [Transcription]; Region: GntR; COG1802 706191006310 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 706191006311 DNA-binding site [nucleotide binding]; DNA binding site 706191006312 FCD domain; Region: FCD; pfam07729 706191006313 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 706191006314 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 706191006315 homotrimer interaction site [polypeptide binding]; other site 706191006316 putative active site [active] 706191006317 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 706191006318 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 706191006319 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 706191006320 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 706191006321 NAD(P) binding site [chemical binding]; other site 706191006322 catalytic residues [active] 706191006323 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 706191006324 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 706191006325 dimer interface [polypeptide binding]; other site 706191006326 active site 706191006327 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 706191006328 substrate binding site [chemical binding]; other site 706191006329 catalytic residue [active] 706191006330 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191006331 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191006332 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 706191006333 dimerization interface [polypeptide binding]; other site 706191006334 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 706191006335 Fasciclin domain; Region: Fasciclin; pfam02469 706191006336 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 706191006337 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706191006338 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 706191006339 DNA binding residues [nucleotide binding] 706191006340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 706191006341 Anti-sigma-K factor rskA; Region: RskA; pfam10099 706191006342 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706191006343 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191006344 dimer interface [polypeptide binding]; other site 706191006345 putative CheW interface [polypeptide binding]; other site 706191006346 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 706191006347 potassium uptake protein; Region: kup; TIGR00794 706191006348 Uncharacterized conserved protein [Function unknown]; Region: COG3791 706191006349 HipA N-terminal domain; Region: Couple_hipA; pfam13657 706191006350 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 706191006351 HipA-like N-terminal domain; Region: HipA_N; pfam07805 706191006352 HipA-like C-terminal domain; Region: HipA_C; pfam07804 706191006353 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 706191006354 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706191006355 non-specific DNA binding site [nucleotide binding]; other site 706191006356 salt bridge; other site 706191006357 sequence-specific DNA binding site [nucleotide binding]; other site 706191006358 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191006359 Coenzyme A binding pocket [chemical binding]; other site 706191006360 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 706191006361 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 706191006362 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 706191006363 putative symporter YagG; Provisional; Region: PRK09669 706191006364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191006365 putative substrate translocation pore; other site 706191006366 Autoinducer synthetase; Region: Autoind_synth; pfam00765 706191006367 Autoinducer binding domain; Region: Autoind_bind; pfam03472 706191006368 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 706191006369 DNA binding residues [nucleotide binding] 706191006370 dimerization interface [polypeptide binding]; other site 706191006371 short chain dehydrogenase; Provisional; Region: PRK06701 706191006372 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 706191006373 NAD binding site [chemical binding]; other site 706191006374 metal binding site [ion binding]; metal-binding site 706191006375 active site 706191006376 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 706191006377 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 706191006378 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706191006379 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 706191006380 hypothetical protein; Provisional; Region: PRK07236 706191006381 FAD binding domain; Region: FAD_binding_3; pfam01494 706191006382 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 706191006383 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 706191006384 active site 706191006385 Zn binding site [ion binding]; other site 706191006386 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 706191006387 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 706191006388 XdhC Rossmann domain; Region: XdhC_C; pfam13478 706191006389 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 706191006390 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 706191006391 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 706191006392 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 706191006393 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 706191006394 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706191006395 guanine deaminase; Provisional; Region: PRK09228 706191006396 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 706191006397 active site 706191006398 malonic semialdehyde reductase; Provisional; Region: PRK10538 706191006399 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 706191006400 putative NAD(P) binding site [chemical binding]; other site 706191006401 homodimer interface [polypeptide binding]; other site 706191006402 homotetramer interface [polypeptide binding]; other site 706191006403 active site 706191006404 hypothetical protein; Provisional; Region: PRK02237 706191006405 hypothetical protein; Provisional; Region: PRK13659 706191006406 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 706191006407 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706191006408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191006409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191006410 putative substrate translocation pore; other site 706191006411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191006412 dimer interface [polypeptide binding]; other site 706191006413 conserved gate region; other site 706191006414 putative PBP binding loops; other site 706191006415 ABC-ATPase subunit interface; other site 706191006416 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 706191006417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191006418 dimer interface [polypeptide binding]; other site 706191006419 conserved gate region; other site 706191006420 ABC-ATPase subunit interface; other site 706191006421 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 706191006422 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 706191006423 Walker A/P-loop; other site 706191006424 ATP binding site [chemical binding]; other site 706191006425 Q-loop/lid; other site 706191006426 ABC transporter signature motif; other site 706191006427 Walker B; other site 706191006428 D-loop; other site 706191006429 H-loop/switch region; other site 706191006430 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 706191006431 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706191006432 AAA domain; Region: AAA_26; pfam13500 706191006433 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 706191006434 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 706191006435 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 706191006436 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 706191006437 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191006438 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 706191006439 dimerization interface [polypeptide binding]; other site 706191006440 substrate binding pocket [chemical binding]; other site 706191006441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191006442 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706191006443 putative substrate translocation pore; other site 706191006444 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 706191006445 putative arabinose transporter; Provisional; Region: PRK03545 706191006446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191006447 putative substrate translocation pore; other site 706191006448 hypothetical protein; Provisional; Region: PRK11019 706191006449 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 706191006450 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 706191006451 peptide binding site [polypeptide binding]; other site 706191006452 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 706191006453 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 706191006454 metal binding site [ion binding]; metal-binding site 706191006455 dimer interface [polypeptide binding]; other site 706191006456 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 706191006457 HAMP domain; Region: HAMP; pfam00672 706191006458 dimerization interface [polypeptide binding]; other site 706191006459 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191006460 dimer interface [polypeptide binding]; other site 706191006461 putative CheW interface [polypeptide binding]; other site 706191006462 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 706191006463 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 706191006464 substrate binding pocket [chemical binding]; other site 706191006465 catalytic triad [active] 706191006466 Predicted membrane protein [Function unknown]; Region: COG2259 706191006467 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 706191006468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 706191006469 benzoate transport; Region: 2A0115; TIGR00895 706191006470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191006471 putative substrate translocation pore; other site 706191006472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191006473 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 706191006474 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191006475 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 706191006476 dimerization interface [polypeptide binding]; other site 706191006477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 706191006478 Smr domain; Region: Smr; pfam01713 706191006479 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 706191006480 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 706191006481 ligand binding site [chemical binding]; other site 706191006482 flexible hinge region; other site 706191006483 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 706191006484 putative switch regulator; other site 706191006485 non-specific DNA interactions [nucleotide binding]; other site 706191006486 DNA binding site [nucleotide binding] 706191006487 sequence specific DNA binding site [nucleotide binding]; other site 706191006488 putative cAMP binding site [chemical binding]; other site 706191006489 universal stress protein UspE; Provisional; Region: PRK11175 706191006490 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 706191006491 Ligand Binding Site [chemical binding]; other site 706191006492 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 706191006493 Ligand Binding Site [chemical binding]; other site 706191006494 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 706191006495 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 706191006496 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 706191006497 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 706191006498 ligand binding site [chemical binding]; other site 706191006499 homodimer interface [polypeptide binding]; other site 706191006500 NAD(P) binding site [chemical binding]; other site 706191006501 trimer interface B [polypeptide binding]; other site 706191006502 trimer interface A [polypeptide binding]; other site 706191006503 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 706191006504 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 706191006505 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 706191006506 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 706191006507 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 706191006508 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 706191006509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191006510 active site 706191006511 phosphorylation site [posttranslational modification] 706191006512 intermolecular recognition site; other site 706191006513 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706191006514 DNA binding site [nucleotide binding] 706191006515 sensor protein RstB; Provisional; Region: PRK10604 706191006516 HAMP domain; Region: HAMP; pfam00672 706191006517 dimerization interface [polypeptide binding]; other site 706191006518 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706191006519 dimer interface [polypeptide binding]; other site 706191006520 phosphorylation site [posttranslational modification] 706191006521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191006522 ATP binding site [chemical binding]; other site 706191006523 Mg2+ binding site [ion binding]; other site 706191006524 G-X-G motif; other site 706191006525 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 706191006526 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 706191006527 active site 706191006528 Zn binding site [ion binding]; other site 706191006529 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 706191006530 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 706191006531 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 706191006532 ATP binding site [chemical binding]; other site 706191006533 putative Mg++ binding site [ion binding]; other site 706191006534 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 706191006535 nucleotide binding region [chemical binding]; other site 706191006536 ATP-binding site [chemical binding]; other site 706191006537 Helicase associated domain (HA2); Region: HA2; pfam04408 706191006538 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 706191006539 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 706191006540 azoreductase; Reviewed; Region: PRK00170 706191006541 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 706191006542 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 706191006543 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 706191006544 hypothetical protein; Provisional; Region: PRK10695 706191006545 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 706191006546 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 706191006547 putative ligand binding site [chemical binding]; other site 706191006548 putative NAD binding site [chemical binding]; other site 706191006549 catalytic site [active] 706191006550 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 706191006551 Domain of unknown function (DUF333); Region: DUF333; pfam03891 706191006552 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 706191006553 MgtC family; Region: MgtC; pfam02308 706191006554 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 706191006555 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 706191006556 Ligand Binding Site [chemical binding]; other site 706191006557 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 706191006558 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 706191006559 Cl binding site [ion binding]; other site 706191006560 oligomer interface [polypeptide binding]; other site 706191006561 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 706191006562 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 706191006563 peptide binding site [polypeptide binding]; other site 706191006564 murein peptide amidase A; Provisional; Region: PRK10602 706191006565 active site 706191006566 Zn binding site [ion binding]; other site 706191006567 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 706191006568 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 706191006569 active site 706191006570 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 706191006571 dimer interface [polypeptide binding]; other site 706191006572 catalytic triad [active] 706191006573 peroxidatic and resolving cysteines [active] 706191006574 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 706191006575 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 706191006576 putative aromatic amino acid binding site; other site 706191006577 PAS domain; Region: PAS; smart00091 706191006578 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191006579 Walker A motif; other site 706191006580 ATP binding site [chemical binding]; other site 706191006581 Walker B motif; other site 706191006582 arginine finger; other site 706191006583 hypothetical protein; Provisional; Region: PRK05415 706191006584 Domain of unknown function (DUF697); Region: DUF697; cl12064 706191006585 Predicted ATPase [General function prediction only]; Region: COG3106 706191006586 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 706191006587 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 706191006588 phage shock protein C; Region: phageshock_pspC; TIGR02978 706191006589 phage shock protein B; Provisional; Region: pspB; PRK09458 706191006590 phage shock protein PspA; Provisional; Region: PRK10698 706191006591 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 706191006592 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191006593 Walker A motif; other site 706191006594 ATP binding site [chemical binding]; other site 706191006595 Walker B motif; other site 706191006596 arginine finger; other site 706191006597 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 706191006598 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 706191006599 Coenzyme A binding pocket [chemical binding]; other site 706191006600 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 706191006601 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 706191006602 peptide binding site [polypeptide binding]; other site 706191006603 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 706191006604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191006605 dimer interface [polypeptide binding]; other site 706191006606 conserved gate region; other site 706191006607 putative PBP binding loops; other site 706191006608 ABC-ATPase subunit interface; other site 706191006609 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 706191006610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191006611 dimer interface [polypeptide binding]; other site 706191006612 conserved gate region; other site 706191006613 putative PBP binding loops; other site 706191006614 ABC-ATPase subunit interface; other site 706191006615 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 706191006616 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706191006617 Walker A/P-loop; other site 706191006618 ATP binding site [chemical binding]; other site 706191006619 Q-loop/lid; other site 706191006620 ABC transporter signature motif; other site 706191006621 Walker B; other site 706191006622 D-loop; other site 706191006623 H-loop/switch region; other site 706191006624 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 706191006625 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 706191006626 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706191006627 Walker A/P-loop; other site 706191006628 ATP binding site [chemical binding]; other site 706191006629 Q-loop/lid; other site 706191006630 ABC transporter signature motif; other site 706191006631 Walker B; other site 706191006632 D-loop; other site 706191006633 H-loop/switch region; other site 706191006634 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 706191006635 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 706191006636 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 706191006637 NAD binding site [chemical binding]; other site 706191006638 homotetramer interface [polypeptide binding]; other site 706191006639 homodimer interface [polypeptide binding]; other site 706191006640 substrate binding site [chemical binding]; other site 706191006641 active site 706191006642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 706191006643 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 706191006644 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191006645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191006646 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 706191006647 dimerization interface [polypeptide binding]; other site 706191006648 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 706191006649 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 706191006650 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 706191006651 active site turn [active] 706191006652 phosphorylation site [posttranslational modification] 706191006653 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 706191006654 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 706191006655 putative molybdopterin cofactor binding site [chemical binding]; other site 706191006656 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 706191006657 putative molybdopterin cofactor binding site; other site 706191006658 exoribonuclease II; Provisional; Region: PRK05054 706191006659 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 706191006660 RNB domain; Region: RNB; pfam00773 706191006661 S1 RNA binding domain; Region: S1; pfam00575 706191006662 carbon starvation protein A; Provisional; Region: PRK15015 706191006663 Carbon starvation protein CstA; Region: CstA; pfam02554 706191006664 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 706191006665 Uncharacterized small protein [Function unknown]; Region: COG2879 706191006666 RNase II stability modulator; Provisional; Region: PRK10060 706191006667 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706191006668 putative active site [active] 706191006669 heme pocket [chemical binding]; other site 706191006670 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706191006671 metal binding site [ion binding]; metal-binding site 706191006672 active site 706191006673 I-site; other site 706191006674 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 706191006675 enoyl-CoA hydratase; Validated; Region: PRK08788 706191006676 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 706191006677 substrate binding site [chemical binding]; other site 706191006678 oxyanion hole (OAH) forming residues; other site 706191006679 trimer interface [polypeptide binding]; other site 706191006680 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 706191006681 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 706191006682 intersubunit interface [polypeptide binding]; other site 706191006683 active site 706191006684 Zn2+ binding site [ion binding]; other site 706191006685 lipoprotein; Provisional; Region: PRK10540 706191006686 translation initiation factor Sui1; Validated; Region: PRK06824 706191006687 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 706191006688 putative rRNA binding site [nucleotide binding]; other site 706191006689 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 706191006690 active site 706191006691 dimer interface [polypeptide binding]; other site 706191006692 tetratricopeptide repeat protein; Provisional; Region: PRK11788 706191006693 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 706191006694 TPR motif; other site 706191006695 binding surface 706191006696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706191006697 binding surface 706191006698 TPR motif; other site 706191006699 Predicted membrane protein [Function unknown]; Region: COG3771 706191006700 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 706191006701 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 706191006702 active site 706191006703 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 706191006704 dimerization interface [polypeptide binding]; other site 706191006705 active site 706191006706 aconitate hydratase; Validated; Region: PRK09277 706191006707 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 706191006708 substrate binding site [chemical binding]; other site 706191006709 ligand binding site [chemical binding]; other site 706191006710 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 706191006711 substrate binding site [chemical binding]; other site 706191006712 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 706191006713 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191006714 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 706191006715 substrate binding site [chemical binding]; other site 706191006716 putative dimerization interface [polypeptide binding]; other site 706191006717 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 706191006718 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 706191006719 active site 706191006720 interdomain interaction site; other site 706191006721 putative metal-binding site [ion binding]; other site 706191006722 nucleotide binding site [chemical binding]; other site 706191006723 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 706191006724 domain I; other site 706191006725 DNA binding groove [nucleotide binding] 706191006726 phosphate binding site [ion binding]; other site 706191006727 domain II; other site 706191006728 domain III; other site 706191006729 nucleotide binding site [chemical binding]; other site 706191006730 catalytic site [active] 706191006731 domain IV; other site 706191006732 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 706191006733 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 706191006734 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 706191006735 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 706191006736 hypothetical protein; Provisional; Region: PRK11037 706191006737 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 706191006738 putative inner membrane peptidase; Provisional; Region: PRK11778 706191006739 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 706191006740 tandem repeat interface [polypeptide binding]; other site 706191006741 oligomer interface [polypeptide binding]; other site 706191006742 active site residues [active] 706191006743 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 706191006744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706191006745 NAD(P) binding site [chemical binding]; other site 706191006746 active site 706191006747 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 706191006748 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 706191006749 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 706191006750 homodimer interface [polypeptide binding]; other site 706191006751 Walker A motif; other site 706191006752 ATP binding site [chemical binding]; other site 706191006753 hydroxycobalamin binding site [chemical binding]; other site 706191006754 Walker B motif; other site 706191006755 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 706191006756 Citrate transporter; Region: CitMHS; pfam03600 706191006757 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 706191006758 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 706191006759 RNA binding surface [nucleotide binding]; other site 706191006760 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 706191006761 probable active site [active] 706191006762 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 706191006763 hypothetical protein; Provisional; Region: PRK11630 706191006764 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 706191006765 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 706191006766 active site 706191006767 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 706191006768 anthranilate synthase component I; Provisional; Region: PRK13564 706191006769 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 706191006770 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 706191006771 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 706191006772 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 706191006773 glutamine binding [chemical binding]; other site 706191006774 catalytic triad [active] 706191006775 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 706191006776 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 706191006777 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 706191006778 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 706191006779 active site 706191006780 ribulose/triose binding site [chemical binding]; other site 706191006781 phosphate binding site [ion binding]; other site 706191006782 substrate (anthranilate) binding pocket [chemical binding]; other site 706191006783 product (indole) binding pocket [chemical binding]; other site 706191006784 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 706191006785 active site 706191006786 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 706191006787 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 706191006788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191006789 catalytic residue [active] 706191006790 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 706191006791 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 706191006792 substrate binding site [chemical binding]; other site 706191006793 active site 706191006794 catalytic residues [active] 706191006795 heterodimer interface [polypeptide binding]; other site 706191006796 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 706191006797 BON domain; Region: BON; pfam04972 706191006798 outer membrane protein W; Provisional; Region: PRK10959 706191006799 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 706191006800 hypothetical protein; Provisional; Region: PRK02868 706191006801 intracellular septation protein A; Reviewed; Region: PRK00259 706191006802 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 706191006803 transport protein TonB; Provisional; Region: PRK10819 706191006804 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 706191006805 YciI-like protein; Reviewed; Region: PRK11370 706191006806 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 706191006807 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 706191006808 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 706191006809 putative active site [active] 706191006810 catalytic site [active] 706191006811 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 706191006812 putative active site [active] 706191006813 catalytic site [active] 706191006814 dsDNA-mimic protein; Reviewed; Region: PRK05094 706191006815 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 706191006816 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706191006817 Walker A/P-loop; other site 706191006818 ATP binding site [chemical binding]; other site 706191006819 Q-loop/lid; other site 706191006820 ABC transporter signature motif; other site 706191006821 Walker B; other site 706191006822 D-loop; other site 706191006823 H-loop/switch region; other site 706191006824 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 706191006825 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 706191006826 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706191006827 Walker A/P-loop; other site 706191006828 ATP binding site [chemical binding]; other site 706191006829 Q-loop/lid; other site 706191006830 ABC transporter signature motif; other site 706191006831 Walker B; other site 706191006832 D-loop; other site 706191006833 H-loop/switch region; other site 706191006834 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 706191006835 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 706191006836 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 706191006837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191006838 dimer interface [polypeptide binding]; other site 706191006839 conserved gate region; other site 706191006840 ABC-ATPase subunit interface; other site 706191006841 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 706191006842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191006843 dimer interface [polypeptide binding]; other site 706191006844 conserved gate region; other site 706191006845 putative PBP binding loops; other site 706191006846 ABC-ATPase subunit interface; other site 706191006847 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 706191006848 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 706191006849 peptide binding site [polypeptide binding]; other site 706191006850 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 706191006851 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 706191006852 peptide binding site [polypeptide binding]; other site 706191006853 hypothetical protein; Provisional; Region: PRK11111 706191006854 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 706191006855 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 706191006856 putative catalytic cysteine [active] 706191006857 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 706191006858 putative active site [active] 706191006859 metal binding site [ion binding]; metal-binding site 706191006860 thymidine kinase; Provisional; Region: PRK04296 706191006861 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 706191006862 ATP binding site [chemical binding]; other site 706191006863 Walker A motif; other site 706191006864 Walker B motif; other site 706191006865 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 706191006866 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 706191006867 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 706191006868 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 706191006869 putative NAD(P) binding site [chemical binding]; other site 706191006870 active site 706191006871 putative substrate binding site [chemical binding]; other site 706191006872 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 706191006873 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 706191006874 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 706191006875 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 706191006876 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 706191006877 active site 706191006878 tetramer interface; other site 706191006879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191006880 active site 706191006881 response regulator of RpoS; Provisional; Region: PRK10693 706191006882 phosphorylation site [posttranslational modification] 706191006883 intermolecular recognition site; other site 706191006884 dimerization interface [polypeptide binding]; other site 706191006885 hypothetical protein; Provisional; Region: PRK10279 706191006886 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 706191006887 active site 706191006888 nucleophile elbow; other site 706191006889 hypothetical protein; Provisional; Region: PRK01617 706191006890 SEC-C motif; Region: SEC-C; pfam02810 706191006891 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 706191006892 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 706191006893 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 706191006894 putative active site [active] 706191006895 putative substrate binding site [chemical binding]; other site 706191006896 putative cosubstrate binding site; other site 706191006897 catalytic site [active] 706191006898 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 706191006899 putative catalytic site [active] 706191006900 putative phosphate binding site [ion binding]; other site 706191006901 active site 706191006902 metal binding site A [ion binding]; metal-binding site 706191006903 DNA binding site [nucleotide binding] 706191006904 putative AP binding site [nucleotide binding]; other site 706191006905 putative metal binding site B [ion binding]; other site 706191006906 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 706191006907 DNA topoisomerase III; Provisional; Region: PRK07726 706191006908 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 706191006909 active site 706191006910 putative interdomain interaction site [polypeptide binding]; other site 706191006911 putative metal-binding site [ion binding]; other site 706191006912 putative nucleotide binding site [chemical binding]; other site 706191006913 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 706191006914 domain I; other site 706191006915 DNA binding groove [nucleotide binding] 706191006916 phosphate binding site [ion binding]; other site 706191006917 domain II; other site 706191006918 domain III; other site 706191006919 nucleotide binding site [chemical binding]; other site 706191006920 catalytic site [active] 706191006921 domain IV; other site 706191006922 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 706191006923 putative FMN binding site [chemical binding]; other site 706191006924 protease 4; Provisional; Region: PRK10949 706191006925 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 706191006926 tandem repeat interface [polypeptide binding]; other site 706191006927 oligomer interface [polypeptide binding]; other site 706191006928 active site residues [active] 706191006929 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 706191006930 tandem repeat interface [polypeptide binding]; other site 706191006931 oligomer interface [polypeptide binding]; other site 706191006932 active site residues [active] 706191006933 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 706191006934 active site 706191006935 homodimer interface [polypeptide binding]; other site 706191006936 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 706191006937 Isochorismatase family; Region: Isochorismatase; pfam00857 706191006938 catalytic triad [active] 706191006939 metal binding site [ion binding]; metal-binding site 706191006940 conserved cis-peptide bond; other site 706191006941 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 706191006942 methionine sulfoxide reductase B; Provisional; Region: PRK00222 706191006943 SelR domain; Region: SelR; pfam01641 706191006944 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 706191006945 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 706191006946 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 706191006947 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 706191006948 active site 706191006949 phosphate binding residues; other site 706191006950 catalytic residues [active] 706191006951 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 706191006952 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 706191006953 active site 706191006954 catalytic tetrad [active] 706191006955 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 706191006956 PrkA family serine protein kinase; Provisional; Region: PRK15455 706191006957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191006958 Walker A motif; other site 706191006959 ATP binding site [chemical binding]; other site 706191006960 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 706191006961 hypothetical protein; Provisional; Region: PRK05325 706191006962 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 706191006963 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 706191006964 TrkA-C domain; Region: TrkA_C; pfam02080 706191006965 Transporter associated domain; Region: CorC_HlyC; smart01091 706191006966 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 706191006967 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 706191006968 Bacterial sugar transferase; Region: Bac_transf; pfam02397 706191006969 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 706191006970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191006971 putative substrate translocation pore; other site 706191006972 alanine racemase; Reviewed; Region: dadX; PRK03646 706191006973 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 706191006974 active site 706191006975 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 706191006976 substrate binding site [chemical binding]; other site 706191006977 catalytic residues [active] 706191006978 dimer interface [polypeptide binding]; other site 706191006979 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 706191006980 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706191006981 hydroxyglutarate oxidase; Provisional; Region: PRK11728 706191006982 SpoVR family protein; Provisional; Region: PRK11767 706191006983 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 706191006984 fatty acid metabolism regulator; Provisional; Region: PRK04984 706191006985 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191006986 DNA-binding site [nucleotide binding]; DNA binding site 706191006987 FadR C-terminal domain; Region: FadR_C; pfam07840 706191006988 disulfide bond formation protein B; Provisional; Region: PRK01749 706191006989 hypothetical protein; Provisional; Region: PRK05170 706191006990 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 706191006991 hypothetical protein; Provisional; Region: PRK10691 706191006992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 706191006993 septum formation inhibitor; Reviewed; Region: minC; PRK03511 706191006994 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 706191006995 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 706191006996 cell division inhibitor MinD; Provisional; Region: PRK10818 706191006997 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 706191006998 Switch I; other site 706191006999 Switch II; other site 706191007000 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 706191007001 ribonuclease D; Provisional; Region: PRK10829 706191007002 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 706191007003 catalytic site [active] 706191007004 putative active site [active] 706191007005 putative substrate binding site [chemical binding]; other site 706191007006 HRDC domain; Region: HRDC; cl02578 706191007007 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 706191007008 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706191007009 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 706191007010 acyl-activating enzyme (AAE) consensus motif; other site 706191007011 putative AMP binding site [chemical binding]; other site 706191007012 putative active site [active] 706191007013 putative CoA binding site [chemical binding]; other site 706191007014 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 706191007015 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 706191007016 Glycoprotease family; Region: Peptidase_M22; pfam00814 706191007017 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 706191007018 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 706191007019 DEAD_2; Region: DEAD_2; pfam06733 706191007020 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 706191007021 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 706191007022 homotrimer interaction site [polypeptide binding]; other site 706191007023 putative active site [active] 706191007024 hypothetical protein; Provisional; Region: PRK05114 706191007025 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 706191007026 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 706191007027 chorismate binding enzyme; Region: Chorismate_bind; cl10555 706191007028 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 706191007029 putative active site [active] 706191007030 putative CoA binding site [chemical binding]; other site 706191007031 nudix motif; other site 706191007032 metal binding site [ion binding]; metal-binding site 706191007033 L-serine deaminase; Provisional; Region: PRK15023 706191007034 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 706191007035 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 706191007036 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 706191007037 phage resistance protein; Provisional; Region: PRK10551 706191007038 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 706191007039 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 706191007040 FOG: CBS domain [General function prediction only]; Region: COG0517 706191007041 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 706191007042 Transporter associated domain; Region: CorC_HlyC; smart01091 706191007043 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 706191007044 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 706191007045 active pocket/dimerization site; other site 706191007046 active site 706191007047 phosphorylation site [posttranslational modification] 706191007048 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 706191007049 active site 706191007050 phosphorylation site [posttranslational modification] 706191007051 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 706191007052 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 706191007053 hypothetical protein; Provisional; Region: PRK02913 706191007054 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 706191007055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191007056 S-adenosylmethionine binding site [chemical binding]; other site 706191007057 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 706191007058 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 706191007059 YebO-like protein; Region: YebO; pfam13974 706191007060 YobH-like protein; Region: YobH; pfam13996 706191007061 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 706191007062 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706191007063 putative DNA binding site [nucleotide binding]; other site 706191007064 putative Zn2+ binding site [ion binding]; other site 706191007065 Bacterial transcriptional regulator; Region: IclR; pfam01614 706191007066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191007067 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706191007068 putative substrate translocation pore; other site 706191007069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191007070 heat shock protein HtpX; Provisional; Region: PRK05457 706191007071 carboxy-terminal protease; Provisional; Region: PRK11186 706191007072 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 706191007073 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 706191007074 protein binding site [polypeptide binding]; other site 706191007075 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 706191007076 Catalytic dyad [active] 706191007077 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 706191007078 ProP expression regulator; Provisional; Region: PRK04950 706191007079 ProQ/FINO family; Region: ProQ; pfam04352 706191007080 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 706191007081 GAF domain; Region: GAF_2; pfam13185 706191007082 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 706191007083 Paraquat-inducible protein A; Region: PqiA; pfam04403 706191007084 Paraquat-inducible protein A; Region: PqiA; pfam04403 706191007085 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 706191007086 mce related protein; Region: MCE; pfam02470 706191007087 mce related protein; Region: MCE; pfam02470 706191007088 mce related protein; Region: MCE; pfam02470 706191007089 mce related protein; Region: MCE; pfam02470 706191007090 mce related protein; Region: MCE; pfam02470 706191007091 mce related protein; Region: MCE; pfam02470 706191007092 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 706191007093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191007094 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 706191007095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 706191007096 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 706191007097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191007098 putative substrate translocation pore; other site 706191007099 choline transport protein BetT; Provisional; Region: PRK09928 706191007100 transcriptional regulator BetI; Validated; Region: PRK00767 706191007101 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706191007102 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 706191007103 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 706191007104 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 706191007105 NAD(P) binding site [chemical binding]; other site 706191007106 catalytic residues [active] 706191007107 choline dehydrogenase; Validated; Region: PRK02106 706191007108 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 706191007109 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 706191007110 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 706191007111 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191007112 Coenzyme A binding pocket [chemical binding]; other site 706191007113 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 706191007114 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191007115 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 706191007116 dimerization interface [polypeptide binding]; other site 706191007117 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 706191007118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706191007119 NAD(P) binding site [chemical binding]; other site 706191007120 active site 706191007121 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 706191007122 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 706191007123 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191007124 dimer interface [polypeptide binding]; other site 706191007125 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 706191007126 putative CheW interface [polypeptide binding]; other site 706191007127 MEKHLA domain; Region: MEKHLA; pfam08670 706191007128 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 706191007129 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 706191007130 NAD binding site [chemical binding]; other site 706191007131 sugar binding site [chemical binding]; other site 706191007132 divalent metal binding site [ion binding]; other site 706191007133 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 706191007134 dimer interface [polypeptide binding]; other site 706191007135 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 706191007136 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 706191007137 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 706191007138 active site turn [active] 706191007139 phosphorylation site [posttranslational modification] 706191007140 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 706191007141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191007142 DNA-binding site [nucleotide binding]; DNA binding site 706191007143 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 706191007144 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 706191007145 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191007146 dimer interface [polypeptide binding]; other site 706191007147 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 706191007148 putative CheW interface [polypeptide binding]; other site 706191007149 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 706191007150 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 706191007151 CopC domain; Region: CopC; pfam04234 706191007152 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 706191007153 exodeoxyribonuclease X; Provisional; Region: PRK07983 706191007154 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 706191007155 active site 706191007156 catalytic site [active] 706191007157 substrate binding site [chemical binding]; other site 706191007158 protease 2; Provisional; Region: PRK10115 706191007159 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 706191007160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 706191007161 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 706191007162 putative metal binding site [ion binding]; other site 706191007163 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 706191007164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706191007165 ATP-grasp domain; Region: ATP-grasp; pfam02222 706191007166 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 706191007167 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 706191007168 active site 706191007169 intersubunit interface [polypeptide binding]; other site 706191007170 catalytic residue [active] 706191007171 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 706191007172 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 706191007173 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 706191007174 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 706191007175 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 706191007176 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 706191007177 putative active site [active] 706191007178 pyruvate kinase; Provisional; Region: PRK05826 706191007179 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 706191007180 domain interfaces; other site 706191007181 active site 706191007182 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 706191007183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191007184 putative substrate translocation pore; other site 706191007185 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 706191007186 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 706191007187 putative acyl-acceptor binding pocket; other site 706191007188 putative peptidase; Provisional; Region: PRK11649 706191007189 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 706191007190 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 706191007191 Peptidase family M23; Region: Peptidase_M23; pfam01551 706191007192 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 706191007193 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 706191007194 metal binding site [ion binding]; metal-binding site 706191007195 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 706191007196 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 706191007197 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 706191007198 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 706191007199 ABC-ATPase subunit interface; other site 706191007200 dimer interface [polypeptide binding]; other site 706191007201 putative PBP binding regions; other site 706191007202 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 706191007203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191007204 Walker A motif; other site 706191007205 ATP binding site [chemical binding]; other site 706191007206 Walker B motif; other site 706191007207 arginine finger; other site 706191007208 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 706191007209 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 706191007210 RuvA N terminal domain; Region: RuvA_N; pfam01330 706191007211 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 706191007212 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 706191007213 active site 706191007214 putative DNA-binding cleft [nucleotide binding]; other site 706191007215 dimer interface [polypeptide binding]; other site 706191007216 hypothetical protein; Validated; Region: PRK00110 706191007217 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 706191007218 nudix motif; other site 706191007219 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 706191007220 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 706191007221 dimer interface [polypeptide binding]; other site 706191007222 anticodon binding site; other site 706191007223 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 706191007224 homodimer interface [polypeptide binding]; other site 706191007225 motif 1; other site 706191007226 active site 706191007227 motif 2; other site 706191007228 GAD domain; Region: GAD; pfam02938 706191007229 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 706191007230 active site 706191007231 motif 3; other site 706191007232 hypothetical protein; Provisional; Region: PRK10302 706191007233 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 706191007234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191007235 S-adenosylmethionine binding site [chemical binding]; other site 706191007236 Methyltransferase domain; Region: Methyltransf_31; pfam13847 706191007237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191007238 S-adenosylmethionine binding site [chemical binding]; other site 706191007239 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 706191007240 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 706191007241 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 706191007242 dimer interface [polypeptide binding]; other site 706191007243 active site 706191007244 metal binding site [ion binding]; metal-binding site 706191007245 copper homeostasis protein CutC; Provisional; Region: PRK11572 706191007246 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 706191007247 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706191007248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191007249 homodimer interface [polypeptide binding]; other site 706191007250 catalytic residue [active] 706191007251 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 706191007252 putative metal binding site [ion binding]; other site 706191007253 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 706191007254 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 706191007255 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 706191007256 active site 706191007257 HIGH motif; other site 706191007258 KMSK motif region; other site 706191007259 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 706191007260 tRNA binding surface [nucleotide binding]; other site 706191007261 anticodon binding site; other site 706191007262 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 706191007263 amphipathic channel; other site 706191007264 Asn-Pro-Ala signature motifs; other site 706191007265 Flagellar protein FlhE; Region: FlhE; pfam06366 706191007266 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 706191007267 FHIPEP family; Region: FHIPEP; pfam00771 706191007268 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 706191007269 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 706191007270 chemotaxis regulator CheZ; Provisional; Region: PRK11166 706191007271 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 706191007272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191007273 active site 706191007274 phosphorylation site [posttranslational modification] 706191007275 intermolecular recognition site; other site 706191007276 dimerization interface [polypeptide binding]; other site 706191007277 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 706191007278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191007279 active site 706191007280 phosphorylation site [posttranslational modification] 706191007281 intermolecular recognition site; other site 706191007282 dimerization interface [polypeptide binding]; other site 706191007283 CheB methylesterase; Region: CheB_methylest; pfam01339 706191007284 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 706191007285 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 706191007286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191007287 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 706191007288 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 706191007289 dimer interface [polypeptide binding]; other site 706191007290 ligand binding site [chemical binding]; other site 706191007291 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706191007292 dimerization interface [polypeptide binding]; other site 706191007293 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191007294 dimer interface [polypeptide binding]; other site 706191007295 putative CheW interface [polypeptide binding]; other site 706191007296 methyl-accepting protein IV; Provisional; Region: PRK09793 706191007297 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 706191007298 dimer interface [polypeptide binding]; other site 706191007299 ligand binding site [chemical binding]; other site 706191007300 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706191007301 dimerization interface [polypeptide binding]; other site 706191007302 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191007303 dimer interface [polypeptide binding]; other site 706191007304 putative CheW interface [polypeptide binding]; other site 706191007305 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 706191007306 putative CheA interaction surface; other site 706191007307 chemotaxis protein CheA; Provisional; Region: PRK10547 706191007308 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 706191007309 putative binding surface; other site 706191007310 active site 706191007311 CheY binding; Region: CheY-binding; pfam09078 706191007312 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 706191007313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191007314 ATP binding site [chemical binding]; other site 706191007315 Mg2+ binding site [ion binding]; other site 706191007316 G-X-G motif; other site 706191007317 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 706191007318 flagellar motor protein MotB; Validated; Region: motB; PRK09041 706191007319 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 706191007320 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 706191007321 ligand binding site [chemical binding]; other site 706191007322 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 706191007323 flagellar motor protein MotA; Validated; Region: PRK09110 706191007324 transcriptional activator FlhC; Provisional; Region: PRK12722 706191007325 transcriptional activator FlhD; Provisional; Region: PRK02909 706191007326 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 706191007327 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 706191007328 active site 706191007329 homotetramer interface [polypeptide binding]; other site 706191007330 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 706191007331 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 706191007332 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 706191007333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191007334 active site 706191007335 phosphorylation site [posttranslational modification] 706191007336 intermolecular recognition site; other site 706191007337 dimerization interface [polypeptide binding]; other site 706191007338 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706191007339 DNA binding site [nucleotide binding] 706191007340 sensor protein BasS/PmrB; Provisional; Region: PRK10755 706191007341 HAMP domain; Region: HAMP; pfam00672 706191007342 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706191007343 dimer interface [polypeptide binding]; other site 706191007344 phosphorylation site [posttranslational modification] 706191007345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191007346 ATP binding site [chemical binding]; other site 706191007347 Mg2+ binding site [ion binding]; other site 706191007348 G-X-G motif; other site 706191007349 methionine sulfoxide reductase A; Provisional; Region: PRK14054 706191007350 Predicted transcriptional regulator [Transcription]; Region: COG2944 706191007351 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706191007352 non-specific DNA binding site [nucleotide binding]; other site 706191007353 salt bridge; other site 706191007354 sequence-specific DNA binding site [nucleotide binding]; other site 706191007355 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 706191007356 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 706191007357 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191007358 substrate binding pocket [chemical binding]; other site 706191007359 membrane-bound complex binding site; other site 706191007360 hinge residues; other site 706191007361 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 706191007362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191007363 Walker A motif; other site 706191007364 ATP binding site [chemical binding]; other site 706191007365 Walker B motif; other site 706191007366 arginine finger; other site 706191007367 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 706191007368 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 706191007369 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191007370 substrate binding pocket [chemical binding]; other site 706191007371 membrane-bound complex binding site; other site 706191007372 hinge residues; other site 706191007373 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 706191007374 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 706191007375 active site 706191007376 dimer interface [polypeptide binding]; other site 706191007377 non-prolyl cis peptide bond; other site 706191007378 insertion regions; other site 706191007379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 706191007380 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 706191007381 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 706191007382 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 706191007383 non-prolyl cis peptide bond; other site 706191007384 active site 706191007385 benzoate transport; Region: 2A0115; TIGR00895 706191007386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191007387 putative substrate translocation pore; other site 706191007388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191007389 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706191007390 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 706191007391 active site 706191007392 hypothetical protein; Provisional; Region: PRK10536 706191007393 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 706191007394 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 706191007395 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 706191007396 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 706191007397 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 706191007398 Imelysin; Region: Peptidase_M75; pfam09375 706191007399 Iron permease FTR1 family; Region: FTR1; cl00475 706191007400 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 706191007401 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 706191007402 Na binding site [ion binding]; other site 706191007403 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 706191007404 Predicted transcriptional regulator [Transcription]; Region: COG3905 706191007405 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 706191007406 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 706191007407 Glutamate binding site [chemical binding]; other site 706191007408 NAD binding site [chemical binding]; other site 706191007409 catalytic residues [active] 706191007410 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 706191007411 Acyltransferase family; Region: Acyl_transf_3; pfam01757 706191007412 Predicted membrane protein [Function unknown]; Region: COG4763 706191007413 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 706191007414 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 706191007415 dimer interface [polypeptide binding]; other site 706191007416 ADP-ribose binding site [chemical binding]; other site 706191007417 active site 706191007418 nudix motif; other site 706191007419 metal binding site [ion binding]; metal-binding site 706191007420 Predicted membrane protein [Function unknown]; Region: COG4763 706191007421 Acyltransferase family; Region: Acyl_transf_3; pfam01757 706191007422 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 706191007423 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 706191007424 Walker A/P-loop; other site 706191007425 ATP binding site [chemical binding]; other site 706191007426 Q-loop/lid; other site 706191007427 ABC transporter signature motif; other site 706191007428 Walker B; other site 706191007429 D-loop; other site 706191007430 H-loop/switch region; other site 706191007431 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 706191007432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191007433 dimer interface [polypeptide binding]; other site 706191007434 conserved gate region; other site 706191007435 putative PBP binding loops; other site 706191007436 ABC-ATPase subunit interface; other site 706191007437 cystine transporter subunit; Provisional; Region: PRK11260 706191007438 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191007439 substrate binding pocket [chemical binding]; other site 706191007440 membrane-bound complex binding site; other site 706191007441 hinge residues; other site 706191007442 D-cysteine desulfhydrase; Validated; Region: PRK03910 706191007443 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 706191007444 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 706191007445 catalytic residue [active] 706191007446 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 706191007447 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 706191007448 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706191007449 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 706191007450 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 706191007451 DNA binding residues [nucleotide binding] 706191007452 HNH endonuclease; Region: HNH_2; pfam13391 706191007453 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 706191007454 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 706191007455 substrate binding site; other site 706191007456 tetramer interface; other site 706191007457 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 706191007458 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 706191007459 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 706191007460 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 706191007461 NADP binding site [chemical binding]; other site 706191007462 active site 706191007463 putative substrate binding site [chemical binding]; other site 706191007464 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 706191007465 NAD(P) binding site [chemical binding]; other site 706191007466 catalytic residues [active] 706191007467 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 706191007468 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 706191007469 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706191007470 acyl-activating enzyme (AAE) consensus motif; other site 706191007471 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 706191007472 AMP binding site [chemical binding]; other site 706191007473 active site 706191007474 acyl-activating enzyme (AAE) consensus motif; other site 706191007475 CoA binding site [chemical binding]; other site 706191007476 transketolase; Reviewed; Region: PRK05899 706191007477 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 706191007478 TPP-binding site [chemical binding]; other site 706191007479 dimer interface [polypeptide binding]; other site 706191007480 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 706191007481 PYR/PP interface [polypeptide binding]; other site 706191007482 dimer interface [polypeptide binding]; other site 706191007483 TPP binding site [chemical binding]; other site 706191007484 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 706191007485 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 706191007486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706191007487 NAD(P) binding site [chemical binding]; other site 706191007488 active site 706191007489 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 706191007490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706191007491 NAD(P) binding site [chemical binding]; other site 706191007492 active site 706191007493 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 706191007494 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 706191007495 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 706191007496 putative trimer interface [polypeptide binding]; other site 706191007497 putative CoA binding site [chemical binding]; other site 706191007498 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 706191007499 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 706191007500 inhibitor-cofactor binding pocket; inhibition site 706191007501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191007502 catalytic residue [active] 706191007503 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 706191007504 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 706191007505 active site 706191007506 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 706191007507 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 706191007508 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 706191007509 Probable Catalytic site; other site 706191007510 metal-binding site 706191007511 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 706191007512 flagellin; Provisional; Region: PRK12802 706191007513 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 706191007514 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 706191007515 flagellin; Reviewed; Region: PRK08869 706191007516 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 706191007517 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 706191007518 flagellin; Reviewed; Region: PRK08869 706191007519 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 706191007520 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 706191007521 flagellin; Provisional; Region: PRK12802 706191007522 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 706191007523 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 706191007524 flagellar capping protein; Reviewed; Region: fliD; PRK08032 706191007525 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 706191007526 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 706191007527 flagellar protein FliS; Validated; Region: fliS; PRK05685 706191007528 Flagellar protein FliT; Region: FliT; cl05125 706191007529 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 706191007530 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 706191007531 active site 706191007532 Na/Ca binding site [ion binding]; other site 706191007533 catalytic site [active] 706191007534 lipoprotein; Provisional; Region: PRK10397 706191007535 anti-RssB factor; Provisional; Region: PRK10244 706191007536 DinI-like family; Region: DinI; cl11630 706191007537 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 706191007538 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 706191007539 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 706191007540 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 706191007541 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 706191007542 FliG C-terminal domain; Region: FliG_C; pfam01706 706191007543 flagellar assembly protein H; Validated; Region: fliH; PRK05687 706191007544 Flagellar assembly protein FliH; Region: FliH; pfam02108 706191007545 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 706191007546 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 706191007547 Walker A motif/ATP binding site; other site 706191007548 Walker B motif; other site 706191007549 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 706191007550 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 706191007551 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 706191007552 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 706191007553 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 706191007554 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 706191007555 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 706191007556 flagellar motor switch protein; Validated; Region: fliN; PRK05698 706191007557 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 706191007558 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 706191007559 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 706191007560 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 706191007561 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 706191007562 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 706191007563 DNA binding residues [nucleotide binding] 706191007564 dimerization interface [polypeptide binding]; other site 706191007565 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 706191007566 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 706191007567 dimer interface [polypeptide binding]; other site 706191007568 ligand binding site [chemical binding]; other site 706191007569 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706191007570 dimerization interface [polypeptide binding]; other site 706191007571 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191007572 dimer interface [polypeptide binding]; other site 706191007573 putative CheW interface [polypeptide binding]; other site 706191007574 hypothetical protein; Provisional; Region: PRK10708 706191007575 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 706191007576 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 706191007577 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 706191007578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191007579 active site 706191007580 motif I; other site 706191007581 motif II; other site 706191007582 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 706191007583 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 706191007584 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 706191007585 hypothetical protein; Provisional; Region: PRK10062 706191007586 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 706191007587 additional DNA contacts [nucleotide binding]; other site 706191007588 mismatch recognition site; other site 706191007589 active site 706191007590 zinc binding site [ion binding]; other site 706191007591 DNA intercalation site [nucleotide binding]; other site 706191007592 DNA cytosine methylase; Provisional; Region: PRK10458 706191007593 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 706191007594 cofactor binding site; other site 706191007595 DNA binding site [nucleotide binding] 706191007596 substrate interaction site [chemical binding]; other site 706191007597 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 706191007598 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 706191007599 dimer interface [polypeptide binding]; other site 706191007600 ligand binding site [chemical binding]; other site 706191007601 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191007602 dimer interface [polypeptide binding]; other site 706191007603 putative CheW interface [polypeptide binding]; other site 706191007604 bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982 706191007605 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 706191007606 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706191007607 Zn2+ binding site [ion binding]; other site 706191007608 Mg2+ binding site [ion binding]; other site 706191007609 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 706191007610 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 706191007611 PemK-like protein; Region: PemK; cl00995 706191007612 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 706191007613 ferrochelatase; Reviewed; Region: hemH; PRK00035 706191007614 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 706191007615 C-terminal domain interface [polypeptide binding]; other site 706191007616 active site 706191007617 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 706191007618 active site 706191007619 N-terminal domain interface [polypeptide binding]; other site 706191007620 H+ Antiporter protein; Region: 2A0121; TIGR00900 706191007621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191007622 putative substrate translocation pore; other site 706191007623 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 706191007624 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706191007625 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 706191007626 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 706191007627 ABC-ATPase subunit interface; other site 706191007628 dimer interface [polypeptide binding]; other site 706191007629 putative PBP binding regions; other site 706191007630 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 706191007631 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 706191007632 putative ligand binding residues [chemical binding]; other site 706191007633 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 706191007634 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191007635 Walker A/P-loop; other site 706191007636 ATP binding site [chemical binding]; other site 706191007637 Q-loop/lid; other site 706191007638 ABC transporter signature motif; other site 706191007639 Walker B; other site 706191007640 D-loop; other site 706191007641 H-loop/switch region; other site 706191007642 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 706191007643 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 706191007644 putative dimer interface [polypeptide binding]; other site 706191007645 HTH domain; Region: HTH_11; pfam08279 706191007646 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 706191007647 PRD domain; Region: PRD; pfam00874 706191007648 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 706191007649 active site 706191007650 P-loop; other site 706191007651 phosphorylation site [posttranslational modification] 706191007652 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 706191007653 active site 706191007654 phosphorylation site [posttranslational modification] 706191007655 alpha-mannosidase; Provisional; Region: PRK09819 706191007656 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 706191007657 active site 706191007658 metal binding site [ion binding]; metal-binding site 706191007659 catalytic site [active] 706191007660 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 706191007661 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 706191007662 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 706191007663 active site 706191007664 P-loop; other site 706191007665 phosphorylation site [posttranslational modification] 706191007666 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 706191007667 active site 706191007668 phosphorylation site [posttranslational modification] 706191007669 PAAR motif; Region: PAAR_motif; pfam05488 706191007670 PAAR motif; Region: PAAR_motif; pfam05488 706191007671 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 706191007672 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 706191007673 RHS Repeat; Region: RHS_repeat; pfam05593 706191007674 RHS Repeat; Region: RHS_repeat; pfam05593 706191007675 RHS protein; Region: RHS; pfam03527 706191007676 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 706191007677 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 706191007678 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 706191007679 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 706191007680 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 706191007681 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 706191007682 Catalytic domain of Protein Kinases; Region: PKc; cd00180 706191007683 active site 706191007684 ATP binding site [chemical binding]; other site 706191007685 substrate binding site [chemical binding]; other site 706191007686 activation loop (A-loop); other site 706191007687 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 706191007688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191007689 Walker A motif; other site 706191007690 ATP binding site [chemical binding]; other site 706191007691 Walker B motif; other site 706191007692 arginine finger; other site 706191007693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191007694 Walker A motif; other site 706191007695 ATP binding site [chemical binding]; other site 706191007696 Walker B motif; other site 706191007697 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 706191007698 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 706191007699 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 706191007700 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 706191007701 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 706191007702 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 706191007703 ImpE protein; Region: ImpE; pfam07024 706191007704 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 706191007705 active site 706191007706 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 706191007707 phosphopeptide binding site; other site 706191007708 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 706191007709 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 706191007710 Protein of unknown function (DUF796); Region: DUF796; pfam05638 706191007711 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 706191007712 Protein of unknown function (DUF877); Region: DUF877; pfam05943 706191007713 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 706191007714 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 706191007715 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 706191007716 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 706191007717 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 706191007718 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 706191007719 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 706191007720 hypothetical protein; Provisional; Region: PRK07033 706191007721 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 706191007722 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 706191007723 ligand binding site [chemical binding]; other site 706191007724 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 706191007725 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 706191007726 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 706191007727 MATE family multidrug exporter; Provisional; Region: PRK10189 706191007728 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 706191007729 AMP nucleosidase; Provisional; Region: PRK08292 706191007730 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 706191007731 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 706191007732 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 706191007733 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 706191007734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191007735 active site 706191007736 phosphorylation site [posttranslational modification] 706191007737 intermolecular recognition site; other site 706191007738 dimerization interface [polypeptide binding]; other site 706191007739 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706191007740 DNA binding site [nucleotide binding] 706191007741 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 706191007742 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 706191007743 substrate binding site [chemical binding]; other site 706191007744 ATP binding site [chemical binding]; other site 706191007745 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 706191007746 intersubunit interface [polypeptide binding]; other site 706191007747 active site 706191007748 zinc binding site [ion binding]; other site 706191007749 Na+ binding site [ion binding]; other site 706191007750 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 706191007751 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 706191007752 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 706191007753 putative ligand binding site [chemical binding]; other site 706191007754 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706191007755 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 706191007756 TM-ABC transporter signature motif; other site 706191007757 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 706191007758 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 706191007759 Walker A/P-loop; other site 706191007760 ATP binding site [chemical binding]; other site 706191007761 Q-loop/lid; other site 706191007762 ABC transporter signature motif; other site 706191007763 Walker B; other site 706191007764 D-loop; other site 706191007765 H-loop/switch region; other site 706191007766 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 706191007767 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 706191007768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706191007769 dimerization interface [polypeptide binding]; other site 706191007770 PAS fold; Region: PAS_7; pfam12860 706191007771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191007772 ATP binding site [chemical binding]; other site 706191007773 Mg2+ binding site [ion binding]; other site 706191007774 G-X-G motif; other site 706191007775 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 706191007776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191007777 active site 706191007778 phosphorylation site [posttranslational modification] 706191007779 intermolecular recognition site; other site 706191007780 dimerization interface [polypeptide binding]; other site 706191007781 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 706191007782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191007783 dimer interface [polypeptide binding]; other site 706191007784 conserved gate region; other site 706191007785 ABC-ATPase subunit interface; other site 706191007786 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 706191007787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191007788 dimer interface [polypeptide binding]; other site 706191007789 conserved gate region; other site 706191007790 putative PBP binding loops; other site 706191007791 ABC-ATPase subunit interface; other site 706191007792 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 706191007793 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 706191007794 substrate binding pocket [chemical binding]; other site 706191007795 membrane-bound complex binding site; other site 706191007796 hinge residues; other site 706191007797 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 706191007798 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 706191007799 Walker A/P-loop; other site 706191007800 ATP binding site [chemical binding]; other site 706191007801 Q-loop/lid; other site 706191007802 ABC transporter signature motif; other site 706191007803 Walker B; other site 706191007804 D-loop; other site 706191007805 H-loop/switch region; other site 706191007806 putative hydrolase; Provisional; Region: PRK02113 706191007807 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 706191007808 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 706191007809 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 706191007810 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 706191007811 active site 706191007812 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 706191007813 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191007814 Walker A/P-loop; other site 706191007815 ATP binding site [chemical binding]; other site 706191007816 Q-loop/lid; other site 706191007817 ABC transporter signature motif; other site 706191007818 Walker B; other site 706191007819 D-loop; other site 706191007820 H-loop/switch region; other site 706191007821 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 706191007822 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706191007823 Walker A/P-loop; other site 706191007824 ATP binding site [chemical binding]; other site 706191007825 Q-loop/lid; other site 706191007826 ABC transporter signature motif; other site 706191007827 Walker B; other site 706191007828 D-loop; other site 706191007829 H-loop/switch region; other site 706191007830 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 706191007831 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 706191007832 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 706191007833 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 706191007834 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 706191007835 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 706191007836 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191007837 DNA-binding site [nucleotide binding]; DNA binding site 706191007838 UTRA domain; Region: UTRA; pfam07702 706191007839 Isochorismatase family; Region: Isochorismatase; pfam00857 706191007840 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 706191007841 catalytic triad [active] 706191007842 conserved cis-peptide bond; other site 706191007843 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 706191007844 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 706191007845 Na binding site [ion binding]; other site 706191007846 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 706191007847 active site 706191007848 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 706191007849 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 706191007850 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 706191007851 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706191007852 putative DNA binding site [nucleotide binding]; other site 706191007853 putative Zn2+ binding site [ion binding]; other site 706191007854 AsnC family; Region: AsnC_trans_reg; pfam01037 706191007855 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 706191007856 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 706191007857 inhibitor-cofactor binding pocket; inhibition site 706191007858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191007859 catalytic residue [active] 706191007860 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 706191007861 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 706191007862 metal binding site [ion binding]; metal-binding site 706191007863 putative dimer interface [polypeptide binding]; other site 706191007864 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 706191007865 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 706191007866 putative ligand binding site [chemical binding]; other site 706191007867 NAD binding site [chemical binding]; other site 706191007868 dimerization interface [polypeptide binding]; other site 706191007869 catalytic site [active] 706191007870 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 706191007871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191007872 Coenzyme A binding pocket [chemical binding]; other site 706191007873 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 706191007874 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 706191007875 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706191007876 Walker A/P-loop; other site 706191007877 ATP binding site [chemical binding]; other site 706191007878 Q-loop/lid; other site 706191007879 ABC transporter signature motif; other site 706191007880 Walker B; other site 706191007881 D-loop; other site 706191007882 H-loop/switch region; other site 706191007883 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706191007884 Walker A/P-loop; other site 706191007885 ATP binding site [chemical binding]; other site 706191007886 Q-loop/lid; other site 706191007887 ABC transporter signature motif; other site 706191007888 Walker B; other site 706191007889 D-loop; other site 706191007890 H-loop/switch region; other site 706191007891 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 706191007892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191007893 dimer interface [polypeptide binding]; other site 706191007894 conserved gate region; other site 706191007895 ABC-ATPase subunit interface; other site 706191007896 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 706191007897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191007898 dimer interface [polypeptide binding]; other site 706191007899 conserved gate region; other site 706191007900 putative PBP binding loops; other site 706191007901 ABC-ATPase subunit interface; other site 706191007902 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 706191007903 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 706191007904 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 706191007905 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 706191007906 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 706191007907 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191007908 motif II; other site 706191007909 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 706191007910 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 706191007911 NAD(P) binding site [chemical binding]; other site 706191007912 catalytic residues [active] 706191007913 succinic semialdehyde dehydrogenase; Region: PLN02278 706191007914 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 706191007915 tetramerization interface [polypeptide binding]; other site 706191007916 NAD(P) binding site [chemical binding]; other site 706191007917 catalytic residues [active] 706191007918 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 706191007919 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191007920 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 706191007921 substrate binding site [chemical binding]; other site 706191007922 dimerization interface [polypeptide binding]; other site 706191007923 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 706191007924 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191007925 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 706191007926 putative dimerization interface [polypeptide binding]; other site 706191007927 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 706191007928 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706191007929 TM-ABC transporter signature motif; other site 706191007930 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 706191007931 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 706191007932 Walker A/P-loop; other site 706191007933 ATP binding site [chemical binding]; other site 706191007934 Q-loop/lid; other site 706191007935 ABC transporter signature motif; other site 706191007936 Walker B; other site 706191007937 D-loop; other site 706191007938 H-loop/switch region; other site 706191007939 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 706191007940 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 706191007941 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 706191007942 putative ligand binding site [chemical binding]; other site 706191007943 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 706191007944 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191007945 dimer interface [polypeptide binding]; other site 706191007946 putative CheW interface [polypeptide binding]; other site 706191007947 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706191007948 catalytic loop [active] 706191007949 iron binding site [ion binding]; other site 706191007950 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 706191007951 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 706191007952 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 706191007953 active site 706191007954 substrate binding site [chemical binding]; other site 706191007955 Mg2+ binding site [ion binding]; other site 706191007956 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 706191007957 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706191007958 putative DNA binding site [nucleotide binding]; other site 706191007959 putative Zn2+ binding site [ion binding]; other site 706191007960 AsnC family; Region: AsnC_trans_reg; pfam01037 706191007961 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 706191007962 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 706191007963 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706191007964 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 706191007965 FAD binding domain; Region: FAD_binding_4; pfam01565 706191007966 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 706191007967 Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537 706191007968 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 706191007969 substrate binding site; other site 706191007970 Manganese binding site; other site 706191007971 dimer interface; other site 706191007972 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 706191007973 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 706191007974 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 706191007975 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706191007976 non-specific DNA binding site [nucleotide binding]; other site 706191007977 salt bridge; other site 706191007978 sequence-specific DNA binding site [nucleotide binding]; other site 706191007979 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 706191007980 Domain of unknown function (DUF718); Region: DUF718; cl01281 706191007981 rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634 706191007982 intersubunit interface [polypeptide binding]; other site 706191007983 active site 706191007984 Zn2+ binding site [ion binding]; other site 706191007985 L-rhamnose isomerase; Provisional; Region: PRK01076 706191007986 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 706191007987 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 706191007988 N- and C-terminal domain interface [polypeptide binding]; other site 706191007989 active site 706191007990 putative catalytic site [active] 706191007991 metal binding site [ion binding]; metal-binding site 706191007992 ATP binding site [chemical binding]; other site 706191007993 rhamnulokinase; Provisional; Region: rhaB; PRK10640 706191007994 carbohydrate binding site [chemical binding]; other site 706191007995 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 706191007996 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 706191007997 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191007998 transcriptional activator RhaR; Provisional; Region: PRK13501 706191007999 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 706191008000 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191008001 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 706191008002 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 706191008003 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 706191008004 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 706191008005 NAD binding site [chemical binding]; other site 706191008006 catalytic residues [active] 706191008007 substrate binding site [chemical binding]; other site 706191008008 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 706191008009 Protein of unknown function (DUF796); Region: DUF796; pfam05638 706191008010 Protein of unknown function (DUF796); Region: DUF796; pfam05638 706191008011 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 706191008012 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 706191008013 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 706191008014 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 706191008015 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 706191008016 lac repressor; Reviewed; Region: lacI; PRK09526 706191008017 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191008018 DNA binding site [nucleotide binding] 706191008019 domain linker motif; other site 706191008020 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 706191008021 ligand binding site [chemical binding]; other site 706191008022 dimerization interface (open form) [polypeptide binding]; other site 706191008023 dimerization interface (closed form) [polypeptide binding]; other site 706191008024 hypothetical protein; Provisional; Region: PRK05423 706191008025 Predicted membrane protein [Function unknown]; Region: COG1289 706191008026 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 706191008027 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 706191008028 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 706191008029 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 706191008030 exonuclease I; Provisional; Region: sbcB; PRK11779 706191008031 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 706191008032 active site 706191008033 catalytic site [active] 706191008034 substrate binding site [chemical binding]; other site 706191008035 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 706191008036 putative transporter; Provisional; Region: PRK09821 706191008037 GntP family permease; Region: GntP_permease; pfam02447 706191008038 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 706191008039 putative aldolase; Validated; Region: PRK08130 706191008040 intersubunit interface [polypeptide binding]; other site 706191008041 active site 706191008042 Zn2+ binding site [ion binding]; other site 706191008043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 706191008044 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 706191008045 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 706191008046 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 706191008047 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 706191008048 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 706191008049 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 706191008050 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 706191008051 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 706191008052 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 706191008053 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 706191008054 catalytic triad [active] 706191008055 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 706191008056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706191008057 non-specific DNA binding site [nucleotide binding]; other site 706191008058 salt bridge; other site 706191008059 sequence-specific DNA binding site [nucleotide binding]; other site 706191008060 Cupin domain; Region: Cupin_2; pfam07883 706191008061 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 706191008062 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 706191008063 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 706191008064 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 706191008065 putative NAD(P) binding site [chemical binding]; other site 706191008066 Histidine operon leader; PANA_ncRNA28 706191008067 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 706191008068 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 706191008069 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 706191008070 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 706191008071 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 706191008072 NAD binding site [chemical binding]; other site 706191008073 dimerization interface [polypeptide binding]; other site 706191008074 product binding site; other site 706191008075 substrate binding site [chemical binding]; other site 706191008076 zinc binding site [ion binding]; other site 706191008077 catalytic residues [active] 706191008078 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 706191008079 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706191008080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191008081 homodimer interface [polypeptide binding]; other site 706191008082 catalytic residue [active] 706191008083 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 706191008084 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 706191008085 putative active site pocket [active] 706191008086 4-fold oligomerization interface [polypeptide binding]; other site 706191008087 metal binding residues [ion binding]; metal-binding site 706191008088 3-fold/trimer interface [polypeptide binding]; other site 706191008089 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 706191008090 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 706191008091 putative active site [active] 706191008092 oxyanion strand; other site 706191008093 catalytic triad [active] 706191008094 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 706191008095 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 706191008096 catalytic residues [active] 706191008097 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 706191008098 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 706191008099 substrate binding site [chemical binding]; other site 706191008100 glutamase interaction surface [polypeptide binding]; other site 706191008101 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 706191008102 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 706191008103 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 706191008104 metal binding site [ion binding]; metal-binding site 706191008105 HipA-like N-terminal domain; Region: HipA_N; pfam07805 706191008106 HipA-like C-terminal domain; Region: HipA_C; pfam07804 706191008107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706191008108 non-specific DNA binding site [nucleotide binding]; other site 706191008109 salt bridge; other site 706191008110 sequence-specific DNA binding site [nucleotide binding]; other site 706191008111 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 706191008112 putative deacylase active site [active] 706191008113 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 706191008114 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191008115 substrate binding pocket [chemical binding]; other site 706191008116 membrane-bound complex binding site; other site 706191008117 hinge residues; other site 706191008118 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 706191008119 active site 706191008120 Zn binding site [ion binding]; other site 706191008121 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 706191008122 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 706191008123 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 706191008124 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 706191008125 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706191008126 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 706191008127 putative ADP-binding pocket [chemical binding]; other site 706191008128 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 706191008129 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706191008130 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 706191008131 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 706191008132 NADP-binding site; other site 706191008133 homotetramer interface [polypeptide binding]; other site 706191008134 substrate binding site [chemical binding]; other site 706191008135 homodimer interface [polypeptide binding]; other site 706191008136 active site 706191008137 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 706191008138 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 706191008139 NADP-binding site; other site 706191008140 homotetramer interface [polypeptide binding]; other site 706191008141 substrate binding site [chemical binding]; other site 706191008142 homodimer interface [polypeptide binding]; other site 706191008143 active site 706191008144 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706191008145 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 706191008146 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 706191008147 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 706191008148 active site 706191008149 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706191008150 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 706191008151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 706191008152 Methyltransferase domain; Region: Methyltransf_23; pfam13489 706191008153 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 706191008154 Walker A/P-loop; other site 706191008155 ATP binding site [chemical binding]; other site 706191008156 ABC transporter; Region: ABC_tran; pfam00005 706191008157 Q-loop/lid; other site 706191008158 ABC transporter signature motif; other site 706191008159 Walker B; other site 706191008160 D-loop; other site 706191008161 H-loop/switch region; other site 706191008162 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 706191008163 putative carbohydrate binding site [chemical binding]; other site 706191008164 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 706191008165 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 706191008166 phosphomannomutase CpsG; Provisional; Region: PRK15414 706191008167 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 706191008168 active site 706191008169 substrate binding site [chemical binding]; other site 706191008170 metal binding site [ion binding]; metal-binding site 706191008171 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 706191008172 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 706191008173 Substrate binding site; other site 706191008174 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 706191008175 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 706191008176 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 706191008177 NAD binding site [chemical binding]; other site 706191008178 homodimer interface [polypeptide binding]; other site 706191008179 active site 706191008180 substrate binding site [chemical binding]; other site 706191008181 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 706191008182 active site 706191008183 tetramer interface; other site 706191008184 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 706191008185 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 706191008186 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 706191008187 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 706191008188 putative ADP-binding pocket [chemical binding]; other site 706191008189 colanic acid biosynthesis protein; Provisional; Region: PRK10017 706191008190 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 706191008191 Head binding; Region: Head_binding; pfam09008 706191008192 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706191008193 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 706191008194 putative ADP-binding pocket [chemical binding]; other site 706191008195 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 706191008196 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 706191008197 active site 706191008198 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 706191008199 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 706191008200 active site 706191008201 tyrosine kinase; Provisional; Region: PRK11519 706191008202 Chain length determinant protein; Region: Wzz; pfam02706 706191008203 Chain length determinant protein; Region: Wzz; cl15801 706191008204 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 706191008205 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706191008206 Low molecular weight phosphatase family; Region: LMWPc; cd00115 706191008207 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 706191008208 active site 706191008209 polysaccharide export protein Wza; Provisional; Region: PRK15078 706191008210 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 706191008211 SLBB domain; Region: SLBB; pfam10531 706191008212 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 706191008213 Bacterial sugar transferase; Region: Bac_transf; pfam02397 706191008214 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 706191008215 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 706191008216 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 706191008217 Transporter associated domain; Region: CorC_HlyC; smart01091 706191008218 putative assembly protein; Provisional; Region: PRK10833 706191008219 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 706191008220 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 706191008221 trimer interface [polypeptide binding]; other site 706191008222 active site 706191008223 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 706191008224 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 706191008225 ATP-binding site [chemical binding]; other site 706191008226 Sugar specificity; other site 706191008227 Pyrimidine base specificity; other site 706191008228 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 706191008229 active site 706191008230 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 706191008231 MASE1; Region: MASE1; cl17823 706191008232 putative diguanylate cyclase; Provisional; Region: PRK09776 706191008233 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706191008234 putative active site [active] 706191008235 heme pocket [chemical binding]; other site 706191008236 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706191008237 putative active site [active] 706191008238 heme pocket [chemical binding]; other site 706191008239 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706191008240 putative active site [active] 706191008241 heme pocket [chemical binding]; other site 706191008242 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706191008243 metal binding site [ion binding]; metal-binding site 706191008244 active site 706191008245 I-site; other site 706191008246 EAL domain; Region: EAL; pfam00563 706191008247 putative chaperone; Provisional; Region: PRK11678 706191008248 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 706191008249 nucleotide binding site [chemical binding]; other site 706191008250 putative NEF/HSP70 interaction site [polypeptide binding]; other site 706191008251 SBD interface [polypeptide binding]; other site 706191008252 Ubiquitin elongating factor core; Region: Ufd2P_core; pfam10408 706191008253 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 706191008254 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706191008255 HlyD family secretion protein; Region: HlyD_3; pfam13437 706191008256 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 706191008257 Protein export membrane protein; Region: SecD_SecF; cl14618 706191008258 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 706191008259 Protein export membrane protein; Region: SecD_SecF; cl14618 706191008260 putative transporter; Provisional; Region: PRK10504 706191008261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191008262 putative substrate translocation pore; other site 706191008263 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 706191008264 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706191008265 dimerization interface [polypeptide binding]; other site 706191008266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706191008267 dimer interface [polypeptide binding]; other site 706191008268 phosphorylation site [posttranslational modification] 706191008269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191008270 ATP binding site [chemical binding]; other site 706191008271 Mg2+ binding site [ion binding]; other site 706191008272 G-X-G motif; other site 706191008273 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 706191008274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191008275 active site 706191008276 phosphorylation site [posttranslational modification] 706191008277 intermolecular recognition site; other site 706191008278 dimerization interface [polypeptide binding]; other site 706191008279 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706191008280 DNA binding site [nucleotide binding] 706191008281 putative protease; Provisional; Region: PRK15452 706191008282 Peptidase family U32; Region: Peptidase_U32; pfam01136 706191008283 lipid kinase; Reviewed; Region: PRK13054 706191008284 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 706191008285 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 706191008286 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 706191008287 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 706191008288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191008289 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 706191008290 DNA-binding site [nucleotide binding]; DNA binding site 706191008291 FCD domain; Region: FCD; pfam07729 706191008292 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 706191008293 dimer interface [polypeptide binding]; other site 706191008294 substrate binding site [chemical binding]; other site 706191008295 ATP binding site [chemical binding]; other site 706191008296 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 706191008297 substrate binding site [chemical binding]; other site 706191008298 multimerization interface [polypeptide binding]; other site 706191008299 ATP binding site [chemical binding]; other site 706191008300 Predicted permeases [General function prediction only]; Region: COG0679 706191008301 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 706191008302 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 706191008303 catalytic residue [active] 706191008304 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 706191008305 catalytic residues [active] 706191008306 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706191008307 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706191008308 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 706191008309 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 706191008310 dimer interface [polypeptide binding]; other site 706191008311 decamer (pentamer of dimers) interface [polypeptide binding]; other site 706191008312 catalytic triad [active] 706191008313 peroxidatic and resolving cysteines [active] 706191008314 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 706191008315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191008316 Coenzyme A binding pocket [chemical binding]; other site 706191008317 antiporter inner membrane protein; Provisional; Region: PRK11670 706191008318 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 706191008319 Walker A motif; other site 706191008320 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 706191008321 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 706191008322 active site 706191008323 HIGH motif; other site 706191008324 KMSKS motif; other site 706191008325 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 706191008326 tRNA binding surface [nucleotide binding]; other site 706191008327 anticodon binding site; other site 706191008328 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 706191008329 dimer interface [polypeptide binding]; other site 706191008330 putative tRNA-binding site [nucleotide binding]; other site 706191008331 hypothetical protein; Provisional; Region: PRK01821 706191008332 hypothetical protein; Provisional; Region: PRK10711 706191008333 cytidine deaminase; Provisional; Region: PRK09027 706191008334 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 706191008335 active site 706191008336 catalytic motif [active] 706191008337 Zn binding site [ion binding]; other site 706191008338 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 706191008339 active site 706191008340 catalytic motif [active] 706191008341 Zn binding site [ion binding]; other site 706191008342 malate dehydrogenase; Provisional; Region: PRK13529 706191008343 Malic enzyme, N-terminal domain; Region: malic; pfam00390 706191008344 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 706191008345 NAD(P) binding site [chemical binding]; other site 706191008346 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 706191008347 putative active site [active] 706191008348 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706191008349 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 706191008350 TM-ABC transporter signature motif; other site 706191008351 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 706191008352 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 706191008353 Walker A/P-loop; other site 706191008354 ATP binding site [chemical binding]; other site 706191008355 Q-loop/lid; other site 706191008356 ABC transporter signature motif; other site 706191008357 Walker B; other site 706191008358 D-loop; other site 706191008359 H-loop/switch region; other site 706191008360 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 706191008361 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 706191008362 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 706191008363 ligand binding site [chemical binding]; other site 706191008364 calcium binding site [ion binding]; other site 706191008365 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 706191008366 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191008367 DNA binding site [nucleotide binding] 706191008368 domain linker motif; other site 706191008369 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 706191008370 dimerization interface (closed form) [polypeptide binding]; other site 706191008371 ligand binding site [chemical binding]; other site 706191008372 Predicted membrane protein [Function unknown]; Region: COG2311 706191008373 hypothetical protein; Provisional; Region: PRK10835 706191008374 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 706191008375 GTP cyclohydrolase I; Provisional; Region: PLN03044 706191008376 active site 706191008377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191008378 putative substrate translocation pore; other site 706191008379 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191008380 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191008381 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 706191008382 putative dimerization interface [polypeptide binding]; other site 706191008383 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 706191008384 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 706191008385 substrate binding site [chemical binding]; other site 706191008386 catalytic Zn binding site [ion binding]; other site 706191008387 NAD binding site [chemical binding]; other site 706191008388 structural Zn binding site [ion binding]; other site 706191008389 dimer interface [polypeptide binding]; other site 706191008390 S-formylglutathione hydrolase; Region: PLN02442 706191008391 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 706191008392 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 706191008393 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 706191008394 Walker A/P-loop; other site 706191008395 ATP binding site [chemical binding]; other site 706191008396 Q-loop/lid; other site 706191008397 ABC transporter signature motif; other site 706191008398 Walker B; other site 706191008399 D-loop; other site 706191008400 H-loop/switch region; other site 706191008401 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 706191008402 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 706191008403 ABC-ATPase subunit interface; other site 706191008404 dimer interface [polypeptide binding]; other site 706191008405 putative PBP binding regions; other site 706191008406 lysine transporter; Provisional; Region: PRK10836 706191008407 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 706191008408 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191008409 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 706191008410 putative dimerization interface [polypeptide binding]; other site 706191008411 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 706191008412 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 706191008413 putative transposase; Provisional; Region: PRK09857 706191008414 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 706191008415 endonuclease IV; Provisional; Region: PRK01060 706191008416 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 706191008417 AP (apurinic/apyrimidinic) site pocket; other site 706191008418 DNA interaction; other site 706191008419 Metal-binding active site; metal-binding site 706191008420 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 706191008421 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 706191008422 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 706191008423 active site 706191008424 P-loop; other site 706191008425 phosphorylation site [posttranslational modification] 706191008426 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 706191008427 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 706191008428 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 706191008429 putative substrate binding site [chemical binding]; other site 706191008430 putative ATP binding site [chemical binding]; other site 706191008431 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 706191008432 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 706191008433 active site 706191008434 phosphorylation site [posttranslational modification] 706191008435 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 706191008436 dimerization domain swap beta strand [polypeptide binding]; other site 706191008437 regulatory protein interface [polypeptide binding]; other site 706191008438 active site 706191008439 regulatory phosphorylation site [posttranslational modification]; other site 706191008440 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 706191008441 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 706191008442 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 706191008443 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 706191008444 inhibitor site; inhibition site 706191008445 active site 706191008446 dimer interface [polypeptide binding]; other site 706191008447 catalytic residue [active] 706191008448 Transcriptional regulators [Transcription]; Region: PurR; COG1609 706191008449 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191008450 DNA binding site [nucleotide binding] 706191008451 domain linker motif; other site 706191008452 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706191008453 benzoate transport; Region: 2A0115; TIGR00895 706191008454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191008455 putative substrate translocation pore; other site 706191008456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191008457 Flagellin N-methylase; Region: FliB; pfam03692 706191008458 elongation factor P; Provisional; Region: PRK04542 706191008459 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 706191008460 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 706191008461 RNA binding site [nucleotide binding]; other site 706191008462 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 706191008463 RNA binding site [nucleotide binding]; other site 706191008464 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 706191008465 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 706191008466 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 706191008467 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 706191008468 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 706191008469 active site 706191008470 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 706191008471 NlpC/P60 family; Region: NLPC_P60; pfam00877 706191008472 phage resistance protein; Provisional; Region: PRK10551 706191008473 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 706191008474 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 706191008475 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 706191008476 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 706191008477 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 706191008478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191008479 dimer interface [polypeptide binding]; other site 706191008480 conserved gate region; other site 706191008481 putative PBP binding loops; other site 706191008482 ABC-ATPase subunit interface; other site 706191008483 microcin C ABC transporter permease; Provisional; Region: PRK15021 706191008484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191008485 dimer interface [polypeptide binding]; other site 706191008486 conserved gate region; other site 706191008487 putative PBP binding loops; other site 706191008488 ABC-ATPase subunit interface; other site 706191008489 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 706191008490 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706191008491 Walker A/P-loop; other site 706191008492 ATP binding site [chemical binding]; other site 706191008493 Q-loop/lid; other site 706191008494 ABC transporter signature motif; other site 706191008495 Walker B; other site 706191008496 D-loop; other site 706191008497 H-loop/switch region; other site 706191008498 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706191008499 Walker A/P-loop; other site 706191008500 ATP binding site [chemical binding]; other site 706191008501 Q-loop/lid; other site 706191008502 ABC transporter signature motif; other site 706191008503 Walker B; other site 706191008504 D-loop; other site 706191008505 H-loop/switch region; other site 706191008506 YejG-like protein; Region: YejG; pfam13989 706191008507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191008508 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 706191008509 putative substrate translocation pore; other site 706191008510 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 706191008511 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 706191008512 RNA binding surface [nucleotide binding]; other site 706191008513 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 706191008514 active site 706191008515 uracil binding [chemical binding]; other site 706191008516 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 706191008517 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 706191008518 ATP binding site [chemical binding]; other site 706191008519 putative Mg++ binding site [ion binding]; other site 706191008520 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 706191008521 nucleotide binding region [chemical binding]; other site 706191008522 ATP-binding site [chemical binding]; other site 706191008523 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 706191008524 5S rRNA interface [nucleotide binding]; other site 706191008525 CTC domain interface [polypeptide binding]; other site 706191008526 L16 interface [polypeptide binding]; other site 706191008527 Nucleoid-associated protein [General function prediction only]; Region: COG3081 706191008528 nucleoid-associated protein NdpA; Validated; Region: PRK00378 706191008529 hypothetical protein; Provisional; Region: PRK13689 706191008530 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 706191008531 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 706191008532 Sulfatase; Region: Sulfatase; cl17466 706191008533 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 706191008534 protease TldD; Provisional; Region: tldD; PRK10735 706191008535 peptidase PmbA; Provisional; Region: PRK11040 706191008536 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 706191008537 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 706191008538 catalytic residues [active] 706191008539 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 706191008540 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 706191008541 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 706191008542 Secretin and TonB N terminus short domain; Region: STN; smart00965 706191008543 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 706191008544 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 706191008545 N-terminal plug; other site 706191008546 ligand-binding site [chemical binding]; other site 706191008547 RNA polymerase sigma factor; Provisional; Region: PRK12525 706191008548 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706191008549 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 706191008550 DNA binding residues [nucleotide binding] 706191008551 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 706191008552 FecR protein; Region: FecR; pfam04773 706191008553 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 706191008554 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 706191008555 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 706191008556 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 706191008557 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 706191008558 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 706191008559 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 706191008560 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 706191008561 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 706191008562 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 706191008563 Mechanosensitive ion channel; Region: MS_channel; pfam00924 706191008564 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 706191008565 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 706191008566 Walker A/P-loop; other site 706191008567 ATP binding site [chemical binding]; other site 706191008568 Q-loop/lid; other site 706191008569 ABC transporter signature motif; other site 706191008570 Walker B; other site 706191008571 D-loop; other site 706191008572 H-loop/switch region; other site 706191008573 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 706191008574 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 706191008575 ApbE family; Region: ApbE; pfam02424 706191008576 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 706191008577 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 706191008578 trimer interface [polypeptide binding]; other site 706191008579 eyelet of channel; other site 706191008580 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 706191008581 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706191008582 HlyD family secretion protein; Region: HlyD_3; pfam13437 706191008583 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 706191008584 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 706191008585 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 706191008586 Walker A/P-loop; other site 706191008587 ATP binding site [chemical binding]; other site 706191008588 Q-loop/lid; other site 706191008589 ABC transporter signature motif; other site 706191008590 Walker B; other site 706191008591 D-loop; other site 706191008592 H-loop/switch region; other site 706191008593 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 706191008594 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 706191008595 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 706191008596 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 706191008597 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 706191008598 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 706191008599 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 706191008600 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 706191008601 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 706191008602 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 706191008603 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 706191008604 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 706191008605 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 706191008606 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 706191008607 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 706191008608 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 706191008609 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 706191008610 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 706191008611 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 706191008612 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 706191008613 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 706191008614 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 706191008615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191008616 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 706191008617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191008618 ATP binding site [chemical binding]; other site 706191008619 Mg2+ binding site [ion binding]; other site 706191008620 G-X-G motif; other site 706191008621 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 706191008622 putative binding surface; other site 706191008623 active site 706191008624 transcriptional regulator RcsB; Provisional; Region: PRK10840 706191008625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191008626 active site 706191008627 phosphorylation site [posttranslational modification] 706191008628 intermolecular recognition site; other site 706191008629 dimerization interface [polypeptide binding]; other site 706191008630 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 706191008631 DNA binding residues [nucleotide binding] 706191008632 dimerization interface [polypeptide binding]; other site 706191008633 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 706191008634 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706191008635 dimer interface [polypeptide binding]; other site 706191008636 phosphorylation site [posttranslational modification] 706191008637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191008638 ATP binding site [chemical binding]; other site 706191008639 Mg2+ binding site [ion binding]; other site 706191008640 G-X-G motif; other site 706191008641 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 706191008642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191008643 active site 706191008644 phosphorylation site [posttranslational modification] 706191008645 intermolecular recognition site; other site 706191008646 dimerization interface [polypeptide binding]; other site 706191008647 DNA gyrase subunit A; Validated; Region: PRK05560 706191008648 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 706191008649 CAP-like domain; other site 706191008650 active site 706191008651 primary dimer interface [polypeptide binding]; other site 706191008652 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 706191008653 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 706191008654 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 706191008655 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 706191008656 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 706191008657 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 706191008658 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 706191008659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191008660 S-adenosylmethionine binding site [chemical binding]; other site 706191008661 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 706191008662 ATP cone domain; Region: ATP-cone; pfam03477 706191008663 Class I ribonucleotide reductase; Region: RNR_I; cd01679 706191008664 active site 706191008665 dimer interface [polypeptide binding]; other site 706191008666 catalytic residues [active] 706191008667 effector binding site; other site 706191008668 R2 peptide binding site; other site 706191008669 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 706191008670 dimer interface [polypeptide binding]; other site 706191008671 putative radical transfer pathway; other site 706191008672 diiron center [ion binding]; other site 706191008673 tyrosyl radical; other site 706191008674 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 706191008675 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706191008676 catalytic loop [active] 706191008677 iron binding site [ion binding]; other site 706191008678 hypothetical protein; Provisional; Region: PRK03673 706191008679 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 706191008680 putative MPT binding site; other site 706191008681 hypothetical protein; Provisional; Region: PRK10404 706191008682 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 706191008683 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 706191008684 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 706191008685 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 706191008686 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 706191008687 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 706191008688 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 706191008689 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 706191008690 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 706191008691 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 706191008692 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 706191008693 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 706191008694 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 706191008695 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 706191008696 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 706191008697 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 706191008698 4Fe-4S binding domain; Region: Fer4; pfam00037 706191008699 4Fe-4S binding domain; Region: Fer4; pfam00037 706191008700 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 706191008701 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 706191008702 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 706191008703 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706191008704 catalytic loop [active] 706191008705 iron binding site [ion binding]; other site 706191008706 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 706191008707 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 706191008708 [4Fe-4S] binding site [ion binding]; other site 706191008709 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 706191008710 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 706191008711 SLBB domain; Region: SLBB; pfam10531 706191008712 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 706191008713 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 706191008714 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 706191008715 putative dimer interface [polypeptide binding]; other site 706191008716 [2Fe-2S] cluster binding site [ion binding]; other site 706191008717 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 706191008718 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 706191008719 NADH dehydrogenase subunit D; Validated; Region: PRK06075 706191008720 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 706191008721 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 706191008722 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 706191008723 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191008724 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 706191008725 putative dimerization interface [polypeptide binding]; other site 706191008726 aminotransferase AlaT; Validated; Region: PRK09265 706191008727 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706191008728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191008729 homodimer interface [polypeptide binding]; other site 706191008730 catalytic residue [active] 706191008731 5'-nucleotidase; Provisional; Region: PRK03826 706191008732 putative phosphatase; Provisional; Region: PRK11587 706191008733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191008734 motif II; other site 706191008735 hypothetical protein; Validated; Region: PRK05445 706191008736 hypothetical protein; Provisional; Region: PRK01816 706191008737 propionate/acetate kinase; Provisional; Region: PRK12379 706191008738 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 706191008739 phosphate acetyltransferase; Reviewed; Region: PRK05632 706191008740 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 706191008741 DRTGG domain; Region: DRTGG; pfam07085 706191008742 phosphate acetyltransferase; Region: pta; TIGR00651 706191008743 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 706191008744 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 706191008745 Walker A/P-loop; other site 706191008746 ATP binding site [chemical binding]; other site 706191008747 Q-loop/lid; other site 706191008748 ABC transporter signature motif; other site 706191008749 Walker B; other site 706191008750 D-loop; other site 706191008751 H-loop/switch region; other site 706191008752 TOBE domain; Region: TOBE_2; pfam08402 706191008753 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 706191008754 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191008755 DNA-binding site [nucleotide binding]; DNA binding site 706191008756 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706191008757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191008758 homodimer interface [polypeptide binding]; other site 706191008759 catalytic residue [active] 706191008760 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 706191008761 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 706191008762 inhibitor-cofactor binding pocket; inhibition site 706191008763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191008764 catalytic residue [active] 706191008765 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 706191008766 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 706191008767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191008768 dimer interface [polypeptide binding]; other site 706191008769 conserved gate region; other site 706191008770 putative PBP binding loops; other site 706191008771 ABC-ATPase subunit interface; other site 706191008772 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 706191008773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191008774 dimer interface [polypeptide binding]; other site 706191008775 conserved gate region; other site 706191008776 putative PBP binding loops; other site 706191008777 ABC-ATPase subunit interface; other site 706191008778 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 706191008779 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 706191008780 nudix motif; other site 706191008781 glutathione S-transferase; Provisional; Region: PRK15113 706191008782 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 706191008783 C-terminal domain interface [polypeptide binding]; other site 706191008784 GSH binding site (G-site) [chemical binding]; other site 706191008785 dimer interface [polypeptide binding]; other site 706191008786 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 706191008787 N-terminal domain interface [polypeptide binding]; other site 706191008788 putative dimer interface [polypeptide binding]; other site 706191008789 putative substrate binding pocket (H-site) [chemical binding]; other site 706191008790 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 706191008791 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 706191008792 putative NAD(P) binding site [chemical binding]; other site 706191008793 putative active site [active] 706191008794 polyol permease family; Region: 2A0118; TIGR00897 706191008795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191008796 putative substrate translocation pore; other site 706191008797 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 706191008798 N- and C-terminal domain interface [polypeptide binding]; other site 706191008799 D-xylulose kinase; Region: XylB; TIGR01312 706191008800 active site 706191008801 MgATP binding site [chemical binding]; other site 706191008802 catalytic site [active] 706191008803 metal binding site [ion binding]; metal-binding site 706191008804 xylulose binding site [chemical binding]; other site 706191008805 homodimer interface [polypeptide binding]; other site 706191008806 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 706191008807 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 706191008808 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 706191008809 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 706191008810 MarR family; Region: MarR_2; pfam12802 706191008811 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 706191008812 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 706191008813 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 706191008814 Walker A/P-loop; other site 706191008815 ATP binding site [chemical binding]; other site 706191008816 Q-loop/lid; other site 706191008817 ABC transporter signature motif; other site 706191008818 Walker B; other site 706191008819 D-loop; other site 706191008820 H-loop/switch region; other site 706191008821 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 706191008822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191008823 dimer interface [polypeptide binding]; other site 706191008824 conserved gate region; other site 706191008825 putative PBP binding loops; other site 706191008826 ABC-ATPase subunit interface; other site 706191008827 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 706191008828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191008829 dimer interface [polypeptide binding]; other site 706191008830 conserved gate region; other site 706191008831 putative PBP binding loops; other site 706191008832 ABC-ATPase subunit interface; other site 706191008833 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 706191008834 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191008835 substrate binding pocket [chemical binding]; other site 706191008836 membrane-bound complex binding site; other site 706191008837 hinge residues; other site 706191008838 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 706191008839 Flavoprotein; Region: Flavoprotein; pfam02441 706191008840 amidophosphoribosyltransferase; Provisional; Region: PRK09246 706191008841 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 706191008842 active site 706191008843 tetramer interface [polypeptide binding]; other site 706191008844 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 706191008845 active site 706191008846 colicin V production protein; Provisional; Region: PRK10845 706191008847 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 706191008848 cell division protein DedD; Provisional; Region: PRK11633 706191008849 Sporulation related domain; Region: SPOR; pfam05036 706191008850 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 706191008851 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 706191008852 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 706191008853 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 706191008854 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 706191008855 hypothetical protein; Provisional; Region: PRK10847 706191008856 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 706191008857 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 706191008858 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 706191008859 dimerization interface 3.5A [polypeptide binding]; other site 706191008860 active site 706191008861 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 706191008862 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 706191008863 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 706191008864 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 706191008865 ligand binding site [chemical binding]; other site 706191008866 NAD binding site [chemical binding]; other site 706191008867 catalytic site [active] 706191008868 homodimer interface [polypeptide binding]; other site 706191008869 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 706191008870 EamA-like transporter family; Region: EamA; pfam00892 706191008871 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 706191008872 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706191008873 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706191008874 dimer interface [polypeptide binding]; other site 706191008875 phosphorylation site [posttranslational modification] 706191008876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191008877 ATP binding site [chemical binding]; other site 706191008878 Mg2+ binding site [ion binding]; other site 706191008879 G-X-G motif; other site 706191008880 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 706191008881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191008882 active site 706191008883 phosphorylation site [posttranslational modification] 706191008884 intermolecular recognition site; other site 706191008885 dimerization interface [polypeptide binding]; other site 706191008886 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706191008887 DNA binding site [nucleotide binding] 706191008888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 706191008889 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 706191008890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 706191008891 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 706191008892 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 706191008893 active site residue [active] 706191008894 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 706191008895 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191008896 DNA-binding site [nucleotide binding]; DNA binding site 706191008897 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706191008898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191008899 homodimer interface [polypeptide binding]; other site 706191008900 catalytic residue [active] 706191008901 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 706191008902 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 706191008903 dimer interface [polypeptide binding]; other site 706191008904 active site 706191008905 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 706191008906 Uncharacterized conserved protein [Function unknown]; Region: COG4121 706191008907 YfcL protein; Region: YfcL; pfam08891 706191008908 Protein of unknown function, DUF462; Region: DUF462; cl01190 706191008909 hypothetical protein; Provisional; Region: PRK10621 706191008910 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 706191008911 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 706191008912 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 706191008913 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 706191008914 Tetramer interface [polypeptide binding]; other site 706191008915 active site 706191008916 FMN-binding site [chemical binding]; other site 706191008917 HemK family putative methylases; Region: hemK_fam; TIGR00536 706191008918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191008919 S-adenosylmethionine binding site [chemical binding]; other site 706191008920 hypothetical protein; Provisional; Region: PRK04946 706191008921 Smr domain; Region: Smr; pfam01713 706191008922 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706191008923 dimerization interface [polypeptide binding]; other site 706191008924 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706191008925 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191008926 dimer interface [polypeptide binding]; other site 706191008927 putative CheW interface [polypeptide binding]; other site 706191008928 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 706191008929 catalytic core [active] 706191008930 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 706191008931 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 706191008932 substrate binding site [chemical binding]; other site 706191008933 oxyanion hole (OAH) forming residues; other site 706191008934 trimer interface [polypeptide binding]; other site 706191008935 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 706191008936 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 706191008937 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 706191008938 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 706191008939 dimer interface [polypeptide binding]; other site 706191008940 active site 706191008941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 706191008942 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 706191008943 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 706191008944 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 706191008945 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 706191008946 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 706191008947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706191008948 binding surface 706191008949 TPR motif; other site 706191008950 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 706191008951 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 706191008952 catalytic residues [active] 706191008953 central insert; other site 706191008954 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 706191008955 CcmE; Region: CcmE; cl00994 706191008956 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 706191008957 heme exporter protein CcmC; Region: ccmC; TIGR01191 706191008958 heme exporter protein CcmB; Region: ccmB; TIGR01190 706191008959 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 706191008960 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 706191008961 Walker A/P-loop; other site 706191008962 ATP binding site [chemical binding]; other site 706191008963 Q-loop/lid; other site 706191008964 ABC transporter signature motif; other site 706191008965 Walker B; other site 706191008966 D-loop; other site 706191008967 H-loop/switch region; other site 706191008968 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 706191008969 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 706191008970 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 706191008971 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 706191008972 putative active site [active] 706191008973 catalytic site [active] 706191008974 putative metal binding site [ion binding]; other site 706191008975 oligomer interface [polypeptide binding]; other site 706191008976 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 706191008977 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191008978 Walker A/P-loop; other site 706191008979 ATP binding site [chemical binding]; other site 706191008980 Q-loop/lid; other site 706191008981 ABC transporter signature motif; other site 706191008982 Walker B; other site 706191008983 D-loop; other site 706191008984 H-loop/switch region; other site 706191008985 TOBE domain; Region: TOBE_2; pfam08402 706191008986 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 706191008987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191008988 dimer interface [polypeptide binding]; other site 706191008989 conserved gate region; other site 706191008990 putative PBP binding loops; other site 706191008991 ABC-ATPase subunit interface; other site 706191008992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191008993 dimer interface [polypeptide binding]; other site 706191008994 conserved gate region; other site 706191008995 putative PBP binding loops; other site 706191008996 ABC-ATPase subunit interface; other site 706191008997 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 706191008998 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 706191008999 Transcriptional regulators [Transcription]; Region: MarR; COG1846 706191009000 MarR family; Region: MarR_2; pfam12802 706191009001 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 706191009002 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 706191009003 nucleotide binding site [chemical binding]; other site 706191009004 Fimbrial protein; Region: Fimbrial; pfam00419 706191009005 Fimbrial protein; Region: Fimbrial; pfam00419 706191009006 Fimbrial protein; Region: Fimbrial; cl01416 706191009007 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 706191009008 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 706191009009 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 706191009010 FaeA-like protein; Region: FaeA; pfam04703 706191009011 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 706191009012 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 706191009013 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 706191009014 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 706191009015 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 706191009016 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 706191009017 PapC N-terminal domain; Region: PapC_N; pfam13954 706191009018 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 706191009019 PapC C-terminal domain; Region: PapC_C; pfam13953 706191009020 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 706191009021 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 706191009022 RES domain; Region: RES; pfam08808 706191009023 Secretin and TonB N terminus short domain; Region: STN; smart00965 706191009024 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 706191009025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191009026 putative substrate translocation pore; other site 706191009027 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 706191009028 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 706191009029 Ligand Binding Site [chemical binding]; other site 706191009030 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 706191009031 Transcriptional regulator [Transcription]; Region: IclR; COG1414 706191009032 Bacterial transcriptional regulator; Region: IclR; pfam01614 706191009033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191009034 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706191009035 putative substrate translocation pore; other site 706191009036 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 706191009037 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706191009038 HlyD family secretion protein; Region: HlyD_3; pfam13437 706191009039 aminotransferase; Validated; Region: PRK08175 706191009040 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706191009041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191009042 homodimer interface [polypeptide binding]; other site 706191009043 catalytic residue [active] 706191009044 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 706191009045 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191009046 Coenzyme A binding pocket [chemical binding]; other site 706191009047 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 706191009048 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 706191009049 GAF domain; Region: GAF_3; pfam13492 706191009050 Histidine kinase; Region: His_kinase; pfam06580 706191009051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191009052 ATP binding site [chemical binding]; other site 706191009053 Mg2+ binding site [ion binding]; other site 706191009054 G-X-G motif; other site 706191009055 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 706191009056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191009057 active site 706191009058 phosphorylation site [posttranslational modification] 706191009059 intermolecular recognition site; other site 706191009060 dimerization interface [polypeptide binding]; other site 706191009061 LytTr DNA-binding domain; Region: LytTR; pfam04397 706191009062 glucokinase, proteobacterial type; Region: glk; TIGR00749 706191009063 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 706191009064 nucleotide binding site [chemical binding]; other site 706191009065 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 706191009066 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 706191009067 dimer interface [polypeptide binding]; other site 706191009068 PYR/PP interface [polypeptide binding]; other site 706191009069 TPP binding site [chemical binding]; other site 706191009070 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 706191009071 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 706191009072 TPP-binding site [chemical binding]; other site 706191009073 dimer interface [polypeptide binding]; other site 706191009074 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 706191009075 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 706191009076 active site 706191009077 catalytic tetrad [active] 706191009078 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 706191009079 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 706191009080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191009081 S-adenosylmethionine binding site [chemical binding]; other site 706191009082 manganese transport protein MntH; Reviewed; Region: PRK00701 706191009083 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 706191009084 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 706191009085 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 706191009086 Nucleoside recognition; Region: Gate; pfam07670 706191009087 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 706191009088 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 706191009089 active site 706191009090 NTP binding site [chemical binding]; other site 706191009091 metal binding triad [ion binding]; metal-binding site 706191009092 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 706191009093 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 706191009094 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 706191009095 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 706191009096 active site 706191009097 HIGH motif; other site 706191009098 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 706191009099 active site 706191009100 KMSKS motif; other site 706191009101 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191009102 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191009103 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 706191009104 putative dimerization interface [polypeptide binding]; other site 706191009105 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 706191009106 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 706191009107 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 706191009108 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 706191009109 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 706191009110 nucleotide binding pocket [chemical binding]; other site 706191009111 K-X-D-G motif; other site 706191009112 catalytic site [active] 706191009113 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 706191009114 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 706191009115 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 706191009116 Dimer interface [polypeptide binding]; other site 706191009117 BRCT sequence motif; other site 706191009118 cell division protein ZipA; Provisional; Region: PRK03427 706191009119 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 706191009120 FtsZ protein binding site [polypeptide binding]; other site 706191009121 putative sulfate transport protein CysZ; Validated; Region: PRK04949 706191009122 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 706191009123 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 706191009124 dimer interface [polypeptide binding]; other site 706191009125 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191009126 catalytic residue [active] 706191009127 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 706191009128 dimerization domain swap beta strand [polypeptide binding]; other site 706191009129 regulatory protein interface [polypeptide binding]; other site 706191009130 active site 706191009131 regulatory phosphorylation site [posttranslational modification]; other site 706191009132 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 706191009133 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 706191009134 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 706191009135 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 706191009136 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 706191009137 HPr interaction site; other site 706191009138 glycerol kinase (GK) interaction site [polypeptide binding]; other site 706191009139 active site 706191009140 phosphorylation site [posttranslational modification] 706191009141 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706191009142 dimerization interface [polypeptide binding]; other site 706191009143 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706191009144 dimer interface [polypeptide binding]; other site 706191009145 phosphorylation site [posttranslational modification] 706191009146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191009147 ATP binding site [chemical binding]; other site 706191009148 Mg2+ binding site [ion binding]; other site 706191009149 G-X-G motif; other site 706191009150 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 706191009151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191009152 active site 706191009153 phosphorylation site [posttranslational modification] 706191009154 intermolecular recognition site; other site 706191009155 dimerization interface [polypeptide binding]; other site 706191009156 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706191009157 DNA binding site [nucleotide binding] 706191009158 cysteine synthase B; Region: cysM; TIGR01138 706191009159 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 706191009160 dimer interface [polypeptide binding]; other site 706191009161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191009162 catalytic residue [active] 706191009163 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 706191009164 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 706191009165 Walker A/P-loop; other site 706191009166 ATP binding site [chemical binding]; other site 706191009167 Q-loop/lid; other site 706191009168 ABC transporter signature motif; other site 706191009169 Walker B; other site 706191009170 D-loop; other site 706191009171 H-loop/switch region; other site 706191009172 TOBE-like domain; Region: TOBE_3; pfam12857 706191009173 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 706191009174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191009175 dimer interface [polypeptide binding]; other site 706191009176 conserved gate region; other site 706191009177 putative PBP binding loops; other site 706191009178 ABC-ATPase subunit interface; other site 706191009179 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 706191009180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191009181 dimer interface [polypeptide binding]; other site 706191009182 conserved gate region; other site 706191009183 putative PBP binding loops; other site 706191009184 ABC-ATPase subunit interface; other site 706191009185 thiosulfate transporter subunit; Provisional; Region: PRK10852 706191009186 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 706191009187 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 706191009188 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 706191009189 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 706191009190 putative acetyltransferase; Provisional; Region: PRK03624 706191009191 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191009192 Coenzyme A binding pocket [chemical binding]; other site 706191009193 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 706191009194 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 706191009195 active site 706191009196 metal binding site [ion binding]; metal-binding site 706191009197 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 706191009198 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 706191009199 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 706191009200 Malic enzyme, N-terminal domain; Region: malic; pfam00390 706191009201 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 706191009202 putative NAD(P) binding site [chemical binding]; other site 706191009203 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 706191009204 transaldolase-like protein; Provisional; Region: PTZ00411 706191009205 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 706191009206 active site 706191009207 dimer interface [polypeptide binding]; other site 706191009208 catalytic residue [active] 706191009209 transketolase; Reviewed; Region: PRK12753 706191009210 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 706191009211 TPP-binding site [chemical binding]; other site 706191009212 dimer interface [polypeptide binding]; other site 706191009213 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 706191009214 PYR/PP interface [polypeptide binding]; other site 706191009215 dimer interface [polypeptide binding]; other site 706191009216 TPP binding site [chemical binding]; other site 706191009217 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 706191009218 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 706191009219 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 706191009220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706191009221 putative active site [active] 706191009222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191009223 ATP binding site [chemical binding]; other site 706191009224 Mg2+ binding site [ion binding]; other site 706191009225 G-X-G motif; other site 706191009226 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 706191009227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191009228 active site 706191009229 phosphorylation site [posttranslational modification] 706191009230 intermolecular recognition site; other site 706191009231 dimerization interface [polypeptide binding]; other site 706191009232 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 706191009233 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 706191009234 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 706191009235 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 706191009236 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 706191009237 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 706191009238 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 706191009239 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 706191009240 ligand binding site [chemical binding]; other site 706191009241 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 706191009242 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 706191009243 Walker A/P-loop; other site 706191009244 ATP binding site [chemical binding]; other site 706191009245 Q-loop/lid; other site 706191009246 ABC transporter signature motif; other site 706191009247 Walker B; other site 706191009248 D-loop; other site 706191009249 H-loop/switch region; other site 706191009250 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 706191009251 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706191009252 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 706191009253 TM-ABC transporter signature motif; other site 706191009254 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706191009255 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 706191009256 TM-ABC transporter signature motif; other site 706191009257 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 706191009258 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 706191009259 substrate binding site [chemical binding]; other site 706191009260 hexamer interface [polypeptide binding]; other site 706191009261 metal binding site [ion binding]; metal-binding site 706191009262 D-allose kinase; Provisional; Region: PRK09698 706191009263 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 706191009264 nucleotide binding site [chemical binding]; other site 706191009265 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 706191009266 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 706191009267 substrate binding site [chemical binding]; other site 706191009268 dimer interface [polypeptide binding]; other site 706191009269 ATP binding site [chemical binding]; other site 706191009270 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 706191009271 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 706191009272 dimer interface [polypeptide binding]; other site 706191009273 ADP-ribose binding site [chemical binding]; other site 706191009274 active site 706191009275 nudix motif; other site 706191009276 metal binding site [ion binding]; metal-binding site 706191009277 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 706191009278 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 706191009279 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 706191009280 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 706191009281 HAMP domain; Region: HAMP; pfam00672 706191009282 Histidine kinase; Region: HisKA_3; pfam07730 706191009283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191009284 ATP binding site [chemical binding]; other site 706191009285 Mg2+ binding site [ion binding]; other site 706191009286 G-X-G motif; other site 706191009287 transcriptional regulator NarP; Provisional; Region: PRK10403 706191009288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191009289 active site 706191009290 phosphorylation site [posttranslational modification] 706191009291 intermolecular recognition site; other site 706191009292 dimerization interface [polypeptide binding]; other site 706191009293 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 706191009294 DNA binding residues [nucleotide binding] 706191009295 dimerization interface [polypeptide binding]; other site 706191009296 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 706191009297 Protein export membrane protein; Region: SecD_SecF; cl14618 706191009298 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 706191009299 ArsC family; Region: ArsC; pfam03960 706191009300 putative catalytic residues [active] 706191009301 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 706191009302 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 706191009303 metal binding site [ion binding]; metal-binding site 706191009304 dimer interface [polypeptide binding]; other site 706191009305 hypothetical protein; Provisional; Region: PRK13664 706191009306 putative hydrolase; Provisional; Region: PRK11460 706191009307 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 706191009308 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 706191009309 Helicase; Region: Helicase_RecD; pfam05127 706191009310 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 706191009311 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 706191009312 Predicted metalloprotease [General function prediction only]; Region: COG2321 706191009313 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 706191009314 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 706191009315 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 706191009316 ATP binding site [chemical binding]; other site 706191009317 active site 706191009318 substrate binding site [chemical binding]; other site 706191009319 lipoprotein; Provisional; Region: PRK11679 706191009320 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 706191009321 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 706191009322 dihydrodipicolinate synthase; Region: dapA; TIGR00674 706191009323 dimer interface [polypeptide binding]; other site 706191009324 active site 706191009325 catalytic residue [active] 706191009326 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 706191009327 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 706191009328 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 706191009329 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 706191009330 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 706191009331 catalytic triad [active] 706191009332 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 706191009333 Domain of unknown function DUF20; Region: UPF0118; pfam01594 706191009334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 706191009335 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 706191009336 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 706191009337 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 706191009338 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 706191009339 Helix-turn-helix domain; Region: HTH_18; pfam12833 706191009340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191009341 Cache domain; Region: Cache_1; pfam02743 706191009342 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 706191009343 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706191009344 metal binding site [ion binding]; metal-binding site 706191009345 active site 706191009346 I-site; other site 706191009347 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 706191009348 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 706191009349 active site 706191009350 metal binding site [ion binding]; metal-binding site 706191009351 hexamer interface [polypeptide binding]; other site 706191009352 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 706191009353 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191009354 Walker A/P-loop; other site 706191009355 ATP binding site [chemical binding]; other site 706191009356 Q-loop/lid; other site 706191009357 ABC transporter signature motif; other site 706191009358 Walker B; other site 706191009359 D-loop; other site 706191009360 H-loop/switch region; other site 706191009361 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 706191009362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191009363 dimer interface [polypeptide binding]; other site 706191009364 conserved gate region; other site 706191009365 putative PBP binding loops; other site 706191009366 ABC-ATPase subunit interface; other site 706191009367 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 706191009368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191009369 dimer interface [polypeptide binding]; other site 706191009370 conserved gate region; other site 706191009371 putative PBP binding loops; other site 706191009372 ABC-ATPase subunit interface; other site 706191009373 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 706191009374 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 706191009375 Transcriptional regulators [Transcription]; Region: PurR; COG1609 706191009376 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191009377 DNA binding site [nucleotide binding] 706191009378 domain linker motif; other site 706191009379 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706191009380 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 706191009381 Peptidase family M48; Region: Peptidase_M48; pfam01435 706191009382 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 706191009383 ArsC family; Region: ArsC; pfam03960 706191009384 catalytic residues [active] 706191009385 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 706191009386 DNA replication initiation factor; Provisional; Region: PRK08084 706191009387 uracil transporter; Provisional; Region: PRK10720 706191009388 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 706191009389 active site 706191009390 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 706191009391 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 706191009392 dimerization interface [polypeptide binding]; other site 706191009393 putative ATP binding site [chemical binding]; other site 706191009394 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 706191009395 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 706191009396 active site 706191009397 substrate binding site [chemical binding]; other site 706191009398 cosubstrate binding site; other site 706191009399 catalytic site [active] 706191009400 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 706191009401 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 706191009402 Walker A/P-loop; other site 706191009403 ATP binding site [chemical binding]; other site 706191009404 Q-loop/lid; other site 706191009405 ABC transporter signature motif; other site 706191009406 Walker B; other site 706191009407 D-loop; other site 706191009408 H-loop/switch region; other site 706191009409 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 706191009410 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 706191009411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191009412 ABC-ATPase subunit interface; other site 706191009413 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 706191009414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191009415 ABC-ATPase subunit interface; other site 706191009416 polyphosphate kinase; Provisional; Region: PRK05443 706191009417 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 706191009418 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 706191009419 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 706191009420 domain interface [polypeptide binding]; other site 706191009421 active site 706191009422 catalytic site [active] 706191009423 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 706191009424 domain interface [polypeptide binding]; other site 706191009425 active site 706191009426 catalytic site [active] 706191009427 exopolyphosphatase; Provisional; Region: PRK10854 706191009428 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 706191009429 nucleotide binding site [chemical binding]; other site 706191009430 tellurite resistance protein TehB; Provisional; Region: PRK11207 706191009431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191009432 S-adenosylmethionine binding site [chemical binding]; other site 706191009433 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 706191009434 MgtE intracellular N domain; Region: MgtE_N; smart00924 706191009435 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 706191009436 Divalent cation transporter; Region: MgtE; cl00786 706191009437 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 706191009438 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 706191009439 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 706191009440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706191009441 TPR motif; other site 706191009442 binding surface 706191009443 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 706191009444 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 706191009445 substrate binding pocket [chemical binding]; other site 706191009446 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 706191009447 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 706191009448 EamA-like transporter family; Region: EamA; pfam00892 706191009449 EamA-like transporter family; Region: EamA; pfam00892 706191009450 AAA domain; Region: AAA_21; pfam13304 706191009451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191009452 Q-loop/lid; other site 706191009453 ABC transporter signature motif; other site 706191009454 Walker B; other site 706191009455 D-loop; other site 706191009456 H-loop/switch region; other site 706191009457 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 706191009458 active site 706191009459 GMP synthase; Reviewed; Region: guaA; PRK00074 706191009460 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 706191009461 AMP/PPi binding site [chemical binding]; other site 706191009462 candidate oxyanion hole; other site 706191009463 catalytic triad [active] 706191009464 potential glutamine specificity residues [chemical binding]; other site 706191009465 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 706191009466 ATP Binding subdomain [chemical binding]; other site 706191009467 Ligand Binding sites [chemical binding]; other site 706191009468 Dimerization subdomain; other site 706191009469 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 706191009470 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 706191009471 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 706191009472 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 706191009473 active site 706191009474 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 706191009475 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 706191009476 generic binding surface II; other site 706191009477 generic binding surface I; other site 706191009478 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 706191009479 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 706191009480 active site 706191009481 Zn binding site [ion binding]; other site 706191009482 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 706191009483 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 706191009484 Trp docking motif [polypeptide binding]; other site 706191009485 putative active site [active] 706191009486 GTP-binding protein Der; Reviewed; Region: PRK00093 706191009487 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 706191009488 G1 box; other site 706191009489 GTP/Mg2+ binding site [chemical binding]; other site 706191009490 Switch I region; other site 706191009491 G2 box; other site 706191009492 Switch II region; other site 706191009493 G3 box; other site 706191009494 G4 box; other site 706191009495 G5 box; other site 706191009496 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 706191009497 G1 box; other site 706191009498 GTP/Mg2+ binding site [chemical binding]; other site 706191009499 Switch I region; other site 706191009500 G2 box; other site 706191009501 G3 box; other site 706191009502 Switch II region; other site 706191009503 G4 box; other site 706191009504 G5 box; other site 706191009505 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 706191009506 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 706191009507 Trp docking motif [polypeptide binding]; other site 706191009508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 706191009509 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 706191009510 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 706191009511 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 706191009512 dimer interface [polypeptide binding]; other site 706191009513 motif 1; other site 706191009514 active site 706191009515 motif 2; other site 706191009516 motif 3; other site 706191009517 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 706191009518 anticodon binding site; other site 706191009519 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 706191009520 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 706191009521 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 706191009522 cytoskeletal protein RodZ; Provisional; Region: PRK10856 706191009523 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706191009524 non-specific DNA binding site [nucleotide binding]; other site 706191009525 salt bridge; other site 706191009526 sequence-specific DNA binding site [nucleotide binding]; other site 706191009527 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 706191009528 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 706191009529 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 706191009530 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706191009531 FeS/SAM binding site; other site 706191009532 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 706191009533 active site 706191009534 multimer interface [polypeptide binding]; other site 706191009535 penicillin-binding protein 1C; Provisional; Region: PRK11240 706191009536 Transglycosylase; Region: Transgly; pfam00912 706191009537 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 706191009538 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 706191009539 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 706191009540 MG2 domain; Region: A2M_N; pfam01835 706191009541 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 706191009542 surface patch; other site 706191009543 thioester region; other site 706191009544 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 706191009545 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 706191009546 active site residue [active] 706191009547 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 706191009548 active site residue [active] 706191009549 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 706191009550 aminopeptidase B; Provisional; Region: PRK05015 706191009551 Peptidase; Region: DUF3663; pfam12404 706191009552 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 706191009553 interface (dimer of trimers) [polypeptide binding]; other site 706191009554 Substrate-binding/catalytic site; other site 706191009555 Zn-binding sites [ion binding]; other site 706191009556 cysteine desulfurase; Provisional; Region: PRK14012 706191009557 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 706191009558 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 706191009559 catalytic residue [active] 706191009560 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 706191009561 Rrf2 family protein; Region: rrf2_super; TIGR00738 706191009562 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 706191009563 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 706191009564 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 706191009565 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 706191009566 active site 706191009567 dimerization interface [polypeptide binding]; other site 706191009568 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 706191009569 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 706191009570 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 706191009571 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 706191009572 PRD domain; Region: PRD; pfam00874 706191009573 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 706191009574 MFS_1 like family; Region: MFS_1_like; pfam12832 706191009575 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 706191009576 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 706191009577 dimer interface [polypeptide binding]; other site 706191009578 active site 706191009579 glycine-pyridoxal phosphate binding site [chemical binding]; other site 706191009580 folate binding site [chemical binding]; other site 706191009581 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 706191009582 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 706191009583 heme-binding site [chemical binding]; other site 706191009584 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 706191009585 FAD binding pocket [chemical binding]; other site 706191009586 FAD binding motif [chemical binding]; other site 706191009587 phosphate binding motif [ion binding]; other site 706191009588 beta-alpha-beta structure motif; other site 706191009589 NAD binding pocket [chemical binding]; other site 706191009590 Heme binding pocket [chemical binding]; other site 706191009591 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 706191009592 Nitrogen regulatory protein P-II; Region: P-II; smart00938 706191009593 response regulator GlrR; Provisional; Region: PRK15115 706191009594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191009595 active site 706191009596 phosphorylation site [posttranslational modification] 706191009597 intermolecular recognition site; other site 706191009598 dimerization interface [polypeptide binding]; other site 706191009599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191009600 Walker A motif; other site 706191009601 ATP binding site [chemical binding]; other site 706191009602 Walker B motif; other site 706191009603 arginine finger; other site 706191009604 hypothetical protein; Provisional; Region: PRK10722 706191009605 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706191009606 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706191009607 dimer interface [polypeptide binding]; other site 706191009608 phosphorylation site [posttranslational modification] 706191009609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191009610 ATP binding site [chemical binding]; other site 706191009611 Mg2+ binding site [ion binding]; other site 706191009612 G-X-G motif; other site 706191009613 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 706191009614 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 706191009615 dimerization interface [polypeptide binding]; other site 706191009616 ATP binding site [chemical binding]; other site 706191009617 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 706191009618 dimerization interface [polypeptide binding]; other site 706191009619 ATP binding site [chemical binding]; other site 706191009620 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 706191009621 putative active site [active] 706191009622 catalytic triad [active] 706191009623 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 706191009624 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191009625 substrate binding pocket [chemical binding]; other site 706191009626 membrane-bound complex binding site; other site 706191009627 hinge residues; other site 706191009628 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 706191009629 N-acetyl-D-glucosamine binding site [chemical binding]; other site 706191009630 catalytic residue [active] 706191009631 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 706191009632 nucleoside/Zn binding site; other site 706191009633 dimer interface [polypeptide binding]; other site 706191009634 catalytic motif [active] 706191009635 hypothetical protein; Provisional; Region: PRK11590 706191009636 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 706191009637 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 706191009638 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 706191009639 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 706191009640 putative active site [active] 706191009641 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 706191009642 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 706191009643 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 706191009644 active site 706191009645 hydrophilic channel; other site 706191009646 dimerization interface [polypeptide binding]; other site 706191009647 catalytic residues [active] 706191009648 active site lid [active] 706191009649 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 706191009650 Recombination protein O N terminal; Region: RecO_N; pfam11967 706191009651 Recombination protein O C terminal; Region: RecO_C; pfam02565 706191009652 GTPase Era; Reviewed; Region: era; PRK00089 706191009653 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 706191009654 G1 box; other site 706191009655 GTP/Mg2+ binding site [chemical binding]; other site 706191009656 Switch I region; other site 706191009657 G2 box; other site 706191009658 Switch II region; other site 706191009659 G3 box; other site 706191009660 G4 box; other site 706191009661 G5 box; other site 706191009662 KH domain; Region: KH_2; pfam07650 706191009663 ribonuclease III; Reviewed; Region: rnc; PRK00102 706191009664 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 706191009665 dimerization interface [polypeptide binding]; other site 706191009666 metal binding site [ion binding]; metal-binding site 706191009667 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 706191009668 dsRNA binding site [nucleotide binding]; other site 706191009669 signal peptidase I; Provisional; Region: PRK10861 706191009670 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 706191009671 Catalytic site [active] 706191009672 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 706191009673 GTP-binding protein LepA; Provisional; Region: PRK05433 706191009674 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 706191009675 G1 box; other site 706191009676 putative GEF interaction site [polypeptide binding]; other site 706191009677 GTP/Mg2+ binding site [chemical binding]; other site 706191009678 Switch I region; other site 706191009679 G2 box; other site 706191009680 G3 box; other site 706191009681 Switch II region; other site 706191009682 G4 box; other site 706191009683 G5 box; other site 706191009684 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 706191009685 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 706191009686 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 706191009687 SoxR reducing system protein RseC; Provisional; Region: PRK10862 706191009688 anti-sigma E factor; Provisional; Region: rseB; PRK09455 706191009689 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 706191009690 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 706191009691 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 706191009692 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 706191009693 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 706191009694 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706191009695 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 706191009696 DNA binding residues [nucleotide binding] 706191009697 L-aspartate oxidase; Provisional; Region: PRK09077 706191009698 L-aspartate oxidase; Provisional; Region: PRK06175 706191009699 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 706191009700 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 706191009701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191009702 S-adenosylmethionine binding site [chemical binding]; other site 706191009703 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 706191009704 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 706191009705 ATP binding site [chemical binding]; other site 706191009706 putative Mg++ binding site [ion binding]; other site 706191009707 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 706191009708 nucleotide binding region [chemical binding]; other site 706191009709 ATP-binding site [chemical binding]; other site 706191009710 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 706191009711 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 706191009712 ligand binding site [chemical binding]; other site 706191009713 active site 706191009714 UGI interface [polypeptide binding]; other site 706191009715 catalytic site [active] 706191009716 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 706191009717 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 706191009718 dimer interface [polypeptide binding]; other site 706191009719 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 706191009720 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 706191009721 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 706191009722 recombination and repair protein; Provisional; Region: PRK10869 706191009723 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 706191009724 Walker A/P-loop; other site 706191009725 ATP binding site [chemical binding]; other site 706191009726 Q-loop/lid; other site 706191009727 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 706191009728 Q-loop/lid; other site 706191009729 ABC transporter signature motif; other site 706191009730 Walker B; other site 706191009731 D-loop; other site 706191009732 H-loop/switch region; other site 706191009733 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 706191009734 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 706191009735 hypothetical protein; Validated; Region: PRK01777 706191009736 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 706191009737 putative coenzyme Q binding site [chemical binding]; other site 706191009738 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 706191009739 SmpB-tmRNA interface; other site 706191009740 integrase; Provisional; Region: PRK09692 706191009741 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 706191009742 active site 706191009743 Int/Topo IB signature motif; other site 706191009744 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 706191009745 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 706191009746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 706191009747 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 706191009748 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 706191009749 Phage associated DNA primase [General function prediction only]; Region: COG3378 706191009750 D5 N terminal like; Region: D5_N; smart00885 706191009751 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 706191009752 PAAR motif; Region: PAAR_motif; pfam05488 706191009753 ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346 706191009754 NAD binding site [chemical binding]; other site 706191009755 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 706191009756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 706191009757 Transposase; Region: HTH_Tnp_1; pfam01527 706191009758 HTH-like domain; Region: HTH_21; pfam13276 706191009759 Integrase core domain; Region: rve; pfam00665 706191009760 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 706191009761 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 706191009762 cofactor binding site; other site 706191009763 DNA binding site [nucleotide binding] 706191009764 substrate interaction site [chemical binding]; other site 706191009765 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 706191009766 Predicted ATPases [General function prediction only]; Region: COG1106 706191009767 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 706191009768 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 706191009769 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706191009770 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 706191009771 Integrase core domain; Region: rve; pfam00665 706191009772 Integrase core domain; Region: rve_3; pfam13683 706191009773 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 706191009774 DNA-binding interface [nucleotide binding]; DNA binding site 706191009775 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 706191009776 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 706191009777 GIY-YIG motif/motif A; other site 706191009778 active site 706191009779 catalytic site [active] 706191009780 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 706191009781 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706191009782 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706191009783 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 706191009784 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 706191009785 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 706191009786 N-terminal plug; other site 706191009787 ligand-binding site [chemical binding]; other site 706191009788 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 706191009789 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 706191009790 putative ligand binding residues [chemical binding]; other site 706191009791 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 706191009792 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 706191009793 ABC-ATPase subunit interface; other site 706191009794 dimer interface [polypeptide binding]; other site 706191009795 putative PBP binding regions; other site 706191009796 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 706191009797 ABC-ATPase subunit interface; other site 706191009798 dimer interface [polypeptide binding]; other site 706191009799 putative PBP binding regions; other site 706191009800 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 706191009801 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 706191009802 Walker A/P-loop; other site 706191009803 ATP binding site [chemical binding]; other site 706191009804 Q-loop/lid; other site 706191009805 ABC transporter signature motif; other site 706191009806 Walker B; other site 706191009807 D-loop; other site 706191009808 H-loop/switch region; other site 706191009809 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 706191009810 Transcriptional regulator [Transcription]; Region: IclR; COG1414 706191009811 Bacterial transcriptional regulator; Region: IclR; pfam01614 706191009812 hypothetical protein; Validated; Region: PRK06201 706191009813 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 706191009814 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 706191009815 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 706191009816 ligand binding site [chemical binding]; other site 706191009817 NAD binding site [chemical binding]; other site 706191009818 dimerization interface [polypeptide binding]; other site 706191009819 catalytic site [active] 706191009820 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 706191009821 Strictosidine synthase; Region: Str_synth; pfam03088 706191009822 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 706191009823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191009824 putative substrate translocation pore; other site 706191009825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191009826 D-galactonate transporter; Region: 2A0114; TIGR00893 706191009827 putative substrate translocation pore; other site 706191009828 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 706191009829 active site 706191009830 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 706191009831 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 706191009832 putative NAD(P) binding site [chemical binding]; other site 706191009833 Predicted transcriptional regulators [Transcription]; Region: COG1733 706191009834 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 706191009835 Right handed beta helix region; Region: Beta_helix; pfam13229 706191009836 hypothetical protein; Provisional; Region: PRK09739 706191009837 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 706191009838 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191009839 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191009840 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 706191009841 putative effector binding pocket; other site 706191009842 putative dimerization interface [polypeptide binding]; other site 706191009843 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706191009844 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 706191009845 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 706191009846 trimer interface [polypeptide binding]; other site 706191009847 eyelet of channel; other site 706191009848 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 706191009849 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 706191009850 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 706191009851 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 706191009852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191009853 active site 706191009854 phosphorylation site [posttranslational modification] 706191009855 intermolecular recognition site; other site 706191009856 dimerization interface [polypeptide binding]; other site 706191009857 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706191009858 DNA binding site [nucleotide binding] 706191009859 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706191009860 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706191009861 dimerization interface [polypeptide binding]; other site 706191009862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706191009863 dimer interface [polypeptide binding]; other site 706191009864 phosphorylation site [posttranslational modification] 706191009865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191009866 ATP binding site [chemical binding]; other site 706191009867 Mg2+ binding site [ion binding]; other site 706191009868 G-X-G motif; other site 706191009869 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 706191009870 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 706191009871 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 706191009872 putative ligand binding residues [chemical binding]; other site 706191009873 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 706191009874 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 706191009875 ABC-ATPase subunit interface; other site 706191009876 dimer interface [polypeptide binding]; other site 706191009877 putative PBP binding regions; other site 706191009878 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 706191009879 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 706191009880 Walker A/P-loop; other site 706191009881 ATP binding site [chemical binding]; other site 706191009882 Q-loop/lid; other site 706191009883 ABC transporter signature motif; other site 706191009884 Walker B; other site 706191009885 D-loop; other site 706191009886 H-loop/switch region; other site 706191009887 FaeA-like protein; Region: FaeA; pfam04703 706191009888 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706191009889 DNA binding site [nucleotide binding] 706191009890 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 706191009891 magnesium-transporting ATPase; Provisional; Region: PRK15122 706191009892 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 706191009893 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 706191009894 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 706191009895 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191009896 motif II; other site 706191009897 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 706191009898 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 706191009899 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 706191009900 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 706191009901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191009902 dimer interface [polypeptide binding]; other site 706191009903 conserved gate region; other site 706191009904 putative PBP binding loops; other site 706191009905 ABC-ATPase subunit interface; other site 706191009906 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 706191009907 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 706191009908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191009909 dimer interface [polypeptide binding]; other site 706191009910 conserved gate region; other site 706191009911 ABC-ATPase subunit interface; other site 706191009912 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 706191009913 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706191009914 Walker A/P-loop; other site 706191009915 ATP binding site [chemical binding]; other site 706191009916 Q-loop/lid; other site 706191009917 ABC transporter signature motif; other site 706191009918 Walker B; other site 706191009919 D-loop; other site 706191009920 H-loop/switch region; other site 706191009921 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 706191009922 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706191009923 Walker A/P-loop; other site 706191009924 ATP binding site [chemical binding]; other site 706191009925 Q-loop/lid; other site 706191009926 ABC transporter signature motif; other site 706191009927 Walker B; other site 706191009928 D-loop; other site 706191009929 H-loop/switch region; other site 706191009930 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 706191009931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191009932 Coenzyme A binding pocket [chemical binding]; other site 706191009933 PEGA domain; Region: PEGA; pfam08308 706191009934 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 706191009935 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 706191009936 S-methylmethionine transporter; Provisional; Region: PRK11387 706191009937 hypothetical protein; Provisional; Region: PRK10556 706191009938 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 706191009939 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 706191009940 catalytic residues [active] 706191009941 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 706191009942 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 706191009943 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 706191009944 Class I ribonucleotide reductase; Region: RNR_I; cd01679 706191009945 active site 706191009946 dimer interface [polypeptide binding]; other site 706191009947 catalytic residues [active] 706191009948 effector binding site; other site 706191009949 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 706191009950 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 706191009951 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 706191009952 dimer interface [polypeptide binding]; other site 706191009953 putative radical transfer pathway; other site 706191009954 diiron center [ion binding]; other site 706191009955 tyrosyl radical; other site 706191009956 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 706191009957 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 706191009958 Walker A/P-loop; other site 706191009959 ATP binding site [chemical binding]; other site 706191009960 Q-loop/lid; other site 706191009961 ABC transporter signature motif; other site 706191009962 Walker B; other site 706191009963 D-loop; other site 706191009964 H-loop/switch region; other site 706191009965 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 706191009966 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 706191009967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191009968 dimer interface [polypeptide binding]; other site 706191009969 conserved gate region; other site 706191009970 putative PBP binding loops; other site 706191009971 ABC-ATPase subunit interface; other site 706191009972 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 706191009973 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 706191009974 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 706191009975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191009976 transcriptional repressor MprA; Provisional; Region: PRK10870 706191009977 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 706191009978 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 706191009979 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706191009980 HlyD family secretion protein; Region: HlyD_3; pfam13437 706191009981 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 706191009982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191009983 putative substrate translocation pore; other site 706191009984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191009985 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 706191009986 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 706191009987 putative NAD(P) binding site [chemical binding]; other site 706191009988 putative substrate binding site [chemical binding]; other site 706191009989 catalytic Zn binding site [ion binding]; other site 706191009990 structural Zn binding site [ion binding]; other site 706191009991 dimer interface [polypeptide binding]; other site 706191009992 Predicted transcriptional regulators [Transcription]; Region: COG1733 706191009993 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 706191009994 putative methyltransferase; Provisional; Region: PRK10864 706191009995 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 706191009996 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 706191009997 thioredoxin 2; Provisional; Region: PRK10996 706191009998 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 706191009999 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 706191010000 catalytic residues [active] 706191010001 Uncharacterized conserved protein [Function unknown]; Region: COG3148 706191010002 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 706191010003 CoA binding domain; Region: CoA_binding_2; pfam13380 706191010004 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 706191010005 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 706191010006 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 706191010007 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 706191010008 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 706191010009 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 706191010010 domain interface [polypeptide binding]; other site 706191010011 putative active site [active] 706191010012 catalytic site [active] 706191010013 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 706191010014 domain interface [polypeptide binding]; other site 706191010015 putative active site [active] 706191010016 catalytic site [active] 706191010017 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 706191010018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191010019 putative substrate translocation pore; other site 706191010020 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 706191010021 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 706191010022 putative NAD(P) binding site [chemical binding]; other site 706191010023 catalytic Zn binding site [ion binding]; other site 706191010024 structural Zn binding site [ion binding]; other site 706191010025 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 706191010026 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 706191010027 putative DNA binding site [nucleotide binding]; other site 706191010028 putative Zn2+ binding site [ion binding]; other site 706191010029 AsnC family; Region: AsnC_trans_reg; pfam01037 706191010030 protein disaggregation chaperone; Provisional; Region: PRK10865 706191010031 Clp amino terminal domain; Region: Clp_N; pfam02861 706191010032 Clp amino terminal domain; Region: Clp_N; pfam02861 706191010033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191010034 Walker A motif; other site 706191010035 ATP binding site [chemical binding]; other site 706191010036 Walker B motif; other site 706191010037 arginine finger; other site 706191010038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191010039 Walker A motif; other site 706191010040 ATP binding site [chemical binding]; other site 706191010041 Walker B motif; other site 706191010042 arginine finger; other site 706191010043 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 706191010044 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 706191010045 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 706191010046 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 706191010047 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 706191010048 RNA binding surface [nucleotide binding]; other site 706191010049 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 706191010050 active site 706191010051 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 706191010052 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 706191010053 30S subunit binding site; other site 706191010054 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 706191010055 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 706191010056 Prephenate dehydratase; Region: PDT; pfam00800 706191010057 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 706191010058 putative L-Phe binding site [chemical binding]; other site 706191010059 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 706191010060 Chorismate mutase type II; Region: CM_2; cl00693 706191010061 prephenate dehydrogenase; Validated; Region: PRK08507 706191010062 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 706191010063 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 706191010064 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 706191010065 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 706191010066 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 706191010067 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 706191010068 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 706191010069 RimM N-terminal domain; Region: RimM; pfam01782 706191010070 PRC-barrel domain; Region: PRC; pfam05239 706191010071 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 706191010072 signal recognition particle protein; Provisional; Region: PRK10867 706191010073 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 706191010074 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 706191010075 P loop; other site 706191010076 GTP binding site [chemical binding]; other site 706191010077 Signal peptide binding domain; Region: SRP_SPB; pfam02978 706191010078 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 706191010079 hypothetical protein; Provisional; Region: PRK11573 706191010080 Domain of unknown function DUF21; Region: DUF21; pfam01595 706191010081 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 706191010082 Transporter associated domain; Region: CorC_HlyC; smart01091 706191010083 S-ribosylhomocysteinase; Provisional; Region: PRK02260 706191010084 glutamate--cysteine ligase; Provisional; Region: PRK02107 706191010085 Predicted membrane protein [Function unknown]; Region: COG1238 706191010086 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 706191010087 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191010088 motif II; other site 706191010089 carbon storage regulator; Provisional; Region: PRK01712 706191010090 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 706191010091 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 706191010092 motif 1; other site 706191010093 active site 706191010094 motif 2; other site 706191010095 motif 3; other site 706191010096 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 706191010097 DHHA1 domain; Region: DHHA1; pfam02272 706191010098 recombination regulator RecX; Reviewed; Region: recX; PRK00117 706191010099 recombinase A; Provisional; Region: recA; PRK09354 706191010100 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 706191010101 hexamer interface [polypeptide binding]; other site 706191010102 Walker A motif; other site 706191010103 ATP binding site [chemical binding]; other site 706191010104 Walker B motif; other site 706191010105 hypothetical protein; Validated; Region: PRK03661 706191010106 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 706191010107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191010108 S-adenosylmethionine binding site [chemical binding]; other site 706191010109 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 706191010110 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 706191010111 PhnA protein; Region: PhnA; pfam03831 706191010112 Transglycosylase SLT domain; Region: SLT_2; pfam13406 706191010113 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 706191010114 N-acetyl-D-glucosamine binding site [chemical binding]; other site 706191010115 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 706191010116 MutS domain I; Region: MutS_I; pfam01624 706191010117 MutS domain II; Region: MutS_II; pfam05188 706191010118 MutS domain III; Region: MutS_III; pfam05192 706191010119 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 706191010120 Walker A/P-loop; other site 706191010121 ATP binding site [chemical binding]; other site 706191010122 Q-loop/lid; other site 706191010123 ABC transporter signature motif; other site 706191010124 Walker B; other site 706191010125 D-loop; other site 706191010126 H-loop/switch region; other site 706191010127 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 706191010128 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706191010129 non-specific DNA binding site [nucleotide binding]; other site 706191010130 salt bridge; other site 706191010131 sequence-specific DNA binding site [nucleotide binding]; other site 706191010132 2TM domain; Region: 2TM; pfam13239 706191010133 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 706191010134 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 706191010135 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 706191010136 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706191010137 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 706191010138 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 706191010139 DNA binding residues [nucleotide binding] 706191010140 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 706191010141 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 706191010142 Peptidase family M23; Region: Peptidase_M23; pfam01551 706191010143 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 706191010144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191010145 S-adenosylmethionine binding site [chemical binding]; other site 706191010146 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 706191010147 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 706191010148 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 706191010149 Permutation of conserved domain; other site 706191010150 active site 706191010151 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 706191010152 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 706191010153 homotrimer interaction site [polypeptide binding]; other site 706191010154 zinc binding site [ion binding]; other site 706191010155 CDP-binding sites; other site 706191010156 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 706191010157 substrate binding site; other site 706191010158 dimer interface; other site 706191010159 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 706191010160 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 706191010161 hypothetical protein; Provisional; Region: PRK10726 706191010162 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 706191010163 ligand-binding site [chemical binding]; other site 706191010164 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 706191010165 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 706191010166 CysD dimerization site [polypeptide binding]; other site 706191010167 G1 box; other site 706191010168 putative GEF interaction site [polypeptide binding]; other site 706191010169 GTP/Mg2+ binding site [chemical binding]; other site 706191010170 Switch I region; other site 706191010171 G2 box; other site 706191010172 G3 box; other site 706191010173 Switch II region; other site 706191010174 G4 box; other site 706191010175 G5 box; other site 706191010176 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 706191010177 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 706191010178 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 706191010179 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 706191010180 Active Sites [active] 706191010181 siroheme synthase; Provisional; Region: cysG; PRK10637 706191010182 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 706191010183 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 706191010184 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 706191010185 active site 706191010186 SAM binding site [chemical binding]; other site 706191010187 homodimer interface [polypeptide binding]; other site 706191010188 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 706191010189 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 706191010190 metal binding site [ion binding]; metal-binding site 706191010191 YCII-related domain; Region: YCII; cl00999 706191010192 Transcriptional regulator [Transcription]; Region: IclR; COG1414 706191010193 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 706191010194 Bacterial transcriptional regulator; Region: IclR; pfam01614 706191010195 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 706191010196 homotrimer interaction site [polypeptide binding]; other site 706191010197 putative active site [active] 706191010198 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 706191010199 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191010200 substrate binding pocket [chemical binding]; other site 706191010201 membrane-bound complex binding site; other site 706191010202 hinge residues; other site 706191010203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191010204 dimer interface [polypeptide binding]; other site 706191010205 conserved gate region; other site 706191010206 putative PBP binding loops; other site 706191010207 ABC-ATPase subunit interface; other site 706191010208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191010209 dimer interface [polypeptide binding]; other site 706191010210 conserved gate region; other site 706191010211 putative PBP binding loops; other site 706191010212 ABC-ATPase subunit interface; other site 706191010213 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 706191010214 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 706191010215 Walker A/P-loop; other site 706191010216 ATP binding site [chemical binding]; other site 706191010217 Q-loop/lid; other site 706191010218 ABC transporter signature motif; other site 706191010219 Walker B; other site 706191010220 D-loop; other site 706191010221 H-loop/switch region; other site 706191010222 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 706191010223 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 706191010224 active site 706191010225 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 706191010226 dimer interface [polypeptide binding]; other site 706191010227 substrate binding site [chemical binding]; other site 706191010228 catalytic residue [active] 706191010229 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 706191010230 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 706191010231 Active Sites [active] 706191010232 sulfite reductase subunit beta; Provisional; Region: PRK13504 706191010233 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 706191010234 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 706191010235 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 706191010236 Flavodoxin; Region: Flavodoxin_1; pfam00258 706191010237 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 706191010238 FAD binding pocket [chemical binding]; other site 706191010239 FAD binding motif [chemical binding]; other site 706191010240 catalytic residues [active] 706191010241 NAD binding pocket [chemical binding]; other site 706191010242 phosphate binding motif [ion binding]; other site 706191010243 beta-alpha-beta structure motif; other site 706191010244 N-acetyltransferase; Region: Acetyltransf_2; cl00949 706191010245 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 706191010246 active site 706191010247 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 706191010248 dimer interface [polypeptide binding]; other site 706191010249 substrate binding site [chemical binding]; other site 706191010250 metal binding sites [ion binding]; metal-binding site 706191010251 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 706191010252 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 706191010253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 706191010254 Nucleoside recognition; Region: Gate; pfam07670 706191010255 hypothetical protein; Provisional; Region: PRK10519 706191010256 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 706191010257 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 706191010258 metal binding site [ion binding]; metal-binding site 706191010259 dimer interface [polypeptide binding]; other site 706191010260 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 706191010261 putative catalytic site [active] 706191010262 putative phosphate binding site [ion binding]; other site 706191010263 putative metal binding site [ion binding]; other site 706191010264 enolase; Provisional; Region: eno; PRK00077 706191010265 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 706191010266 dimer interface [polypeptide binding]; other site 706191010267 metal binding site [ion binding]; metal-binding site 706191010268 substrate binding pocket [chemical binding]; other site 706191010269 CTP synthetase; Validated; Region: pyrG; PRK05380 706191010270 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 706191010271 Catalytic site [active] 706191010272 active site 706191010273 UTP binding site [chemical binding]; other site 706191010274 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 706191010275 active site 706191010276 putative oxyanion hole; other site 706191010277 catalytic triad [active] 706191010278 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 706191010279 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 706191010280 homodimer interface [polypeptide binding]; other site 706191010281 metal binding site [ion binding]; metal-binding site 706191010282 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 706191010283 homodimer interface [polypeptide binding]; other site 706191010284 active site 706191010285 putative chemical substrate binding site [chemical binding]; other site 706191010286 metal binding site [ion binding]; metal-binding site 706191010287 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 706191010288 HD domain; Region: HD_4; pfam13328 706191010289 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 706191010290 synthetase active site [active] 706191010291 NTP binding site [chemical binding]; other site 706191010292 metal binding site [ion binding]; metal-binding site 706191010293 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 706191010294 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 706191010295 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 706191010296 TRAM domain; Region: TRAM; pfam01938 706191010297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191010298 S-adenosylmethionine binding site [chemical binding]; other site 706191010299 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 706191010300 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 706191010301 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706191010302 dimerization interface [polypeptide binding]; other site 706191010303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706191010304 dimer interface [polypeptide binding]; other site 706191010305 phosphorylation site [posttranslational modification] 706191010306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191010307 ATP binding site [chemical binding]; other site 706191010308 Mg2+ binding site [ion binding]; other site 706191010309 G-X-G motif; other site 706191010310 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 706191010311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191010312 active site 706191010313 phosphorylation site [posttranslational modification] 706191010314 intermolecular recognition site; other site 706191010315 dimerization interface [polypeptide binding]; other site 706191010316 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 706191010317 putative binding surface; other site 706191010318 active site 706191010319 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 706191010320 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 706191010321 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 706191010322 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 706191010323 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 706191010324 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 706191010325 active site 706191010326 tetramer interface [polypeptide binding]; other site 706191010327 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 706191010328 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 706191010329 active site 706191010330 tetramer interface [polypeptide binding]; other site 706191010331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191010332 D-galactonate transporter; Region: 2A0114; TIGR00893 706191010333 putative substrate translocation pore; other site 706191010334 galactarate dehydratase; Region: galactar-dH20; TIGR03248 706191010335 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 706191010336 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 706191010337 flavodoxin; Provisional; Region: PRK08105 706191010338 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 706191010339 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 706191010340 probable active site [active] 706191010341 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 706191010342 SecY interacting protein Syd; Provisional; Region: PRK04968 706191010343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 706191010344 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 706191010345 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 706191010346 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 706191010347 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 706191010348 flap endonuclease-like protein; Provisional; Region: PRK09482 706191010349 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 706191010350 active site 706191010351 metal binding site 1 [ion binding]; metal-binding site 706191010352 putative 5' ssDNA interaction site; other site 706191010353 metal binding site 3; metal-binding site 706191010354 metal binding site 2 [ion binding]; metal-binding site 706191010355 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 706191010356 putative DNA binding site [nucleotide binding]; other site 706191010357 putative metal binding site [ion binding]; other site 706191010358 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 706191010359 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 706191010360 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 706191010361 hypothetical protein; Provisional; Region: PRK10873 706191010362 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 706191010363 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191010364 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 706191010365 dimerization interface [polypeptide binding]; other site 706191010366 substrate binding pocket [chemical binding]; other site 706191010367 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 706191010368 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 706191010369 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 706191010370 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 706191010371 catalytic residue [active] 706191010372 cysteine desulfurase, sulfur acceptor subunit CsdE; Region: FeS_syn_CsdE; TIGR03391 706191010373 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 706191010374 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 706191010375 putative ATP binding site [chemical binding]; other site 706191010376 putative substrate interface [chemical binding]; other site 706191010377 murein transglycosylase A; Provisional; Region: mltA; PRK11162 706191010378 MltA specific insert domain; Region: MltA; smart00925 706191010379 3D domain; Region: 3D; pfam06725 706191010380 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 706191010381 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 706191010382 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 706191010383 catalytic residue [active] 706191010384 AMIN domain; Region: AMIN; pfam11741 706191010385 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 706191010386 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 706191010387 active site 706191010388 metal binding site [ion binding]; metal-binding site 706191010389 N-acetylglutamate synthase; Validated; Region: PRK05279 706191010390 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 706191010391 putative feedback inhibition sensing region; other site 706191010392 putative nucleotide binding site [chemical binding]; other site 706191010393 putative substrate binding site [chemical binding]; other site 706191010394 N-acetylglutamate synthase and related acetyltransferases [Amino acid transport and metabolism]; Region: ArgA; COG1246 706191010395 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 706191010396 AAA domain; Region: AAA_30; pfam13604 706191010397 Family description; Region: UvrD_C_2; pfam13538 706191010398 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 706191010399 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 706191010400 protease3; Provisional; Region: PRK15101 706191010401 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 706191010402 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 706191010403 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 706191010404 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 706191010405 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 706191010406 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 706191010407 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 706191010408 hypothetical protein; Provisional; Region: PRK10557 706191010409 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 706191010410 hypothetical protein; Provisional; Region: PRK10506 706191010411 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 706191010412 thymidylate synthase; Reviewed; Region: thyA; PRK01827 706191010413 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 706191010414 dimerization interface [polypeptide binding]; other site 706191010415 active site 706191010416 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 706191010417 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 706191010418 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 706191010419 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 706191010420 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 706191010421 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 706191010422 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 706191010423 putative active site [active] 706191010424 Ap4A binding site [chemical binding]; other site 706191010425 nudix motif; other site 706191010426 putative metal binding site [ion binding]; other site 706191010427 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 706191010428 putative DNA-binding cleft [nucleotide binding]; other site 706191010429 putative DNA clevage site; other site 706191010430 molecular lever; other site 706191010431 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 706191010432 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 706191010433 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 706191010434 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 706191010435 active site 706191010436 catalytic tetrad [active] 706191010437 diaminopimelate decarboxylase; Provisional; Region: PRK11165 706191010438 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 706191010439 active site 706191010440 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 706191010441 substrate binding site [chemical binding]; other site 706191010442 catalytic residues [active] 706191010443 dimer interface [polypeptide binding]; other site 706191010444 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 706191010445 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191010446 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 706191010447 dimerization interface [polypeptide binding]; other site 706191010448 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 706191010449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191010450 putative substrate translocation pore; other site 706191010451 Cupin domain; Region: Cupin_2; cl17218 706191010452 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 706191010453 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 706191010454 dimer interface [polypeptide binding]; other site 706191010455 putative anticodon binding site; other site 706191010456 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 706191010457 motif 1; other site 706191010458 active site 706191010459 motif 2; other site 706191010460 motif 3; other site 706191010461 peptide chain release factor 2; Validated; Region: prfB; PRK00578 706191010462 This domain is found in peptide chain release factors; Region: PCRF; smart00937 706191010463 RF-1 domain; Region: RF-1; pfam00472 706191010464 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 706191010465 DHH family; Region: DHH; pfam01368 706191010466 DHHA1 domain; Region: DHHA1; pfam02272 706191010467 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 706191010468 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 706191010469 dimerization domain [polypeptide binding]; other site 706191010470 dimer interface [polypeptide binding]; other site 706191010471 catalytic residues [active] 706191010472 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 706191010473 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 706191010474 active site 706191010475 Int/Topo IB signature motif; other site 706191010476 tail protein; Provisional; Region: D; PHA02561 706191010477 Phage protein U [General function prediction only]; Region: COG3499 706191010478 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 706191010479 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 706191010480 membrane protein P6; Region: PHA01399 706191010481 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 706191010482 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 706191010483 major tail tube protein; Provisional; Region: FII; PHA02600 706191010484 major tail sheath protein; Provisional; Region: FI; PHA02560 706191010485 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 706191010486 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 706191010487 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 706191010488 Phage Tail Collar Domain; Region: Collar; pfam07484 706191010489 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 706191010490 Baseplate J-like protein; Region: Baseplate_J; cl01294 706191010491 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 706191010492 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 706191010493 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 706191010494 FRG domain; Region: FRG; pfam08867 706191010495 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 706191010496 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 706191010497 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 706191010498 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 706191010499 catalytic residues [active] 706191010500 Phage Tail Protein X; Region: Phage_tail_X; cl02088 706191010501 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 706191010502 terminase endonuclease subunit; Provisional; Region: M; PHA02537 706191010503 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 706191010504 capsid protein; Provisional; Region: N; PHA02538 706191010505 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 706191010506 terminase ATPase subunit; Provisional; Region: P; PHA02535 706191010507 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 706191010508 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 706191010509 portal vertex protein; Provisional; Region: Q; PHA02536 706191010510 Phage portal protein; Region: Phage_portal; pfam04860 706191010511 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 706191010512 ParB-like nuclease domain; Region: ParB; smart00470 706191010513 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 706191010514 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 706191010515 cofactor binding site; other site 706191010516 DNA binding site [nucleotide binding] 706191010517 substrate interaction site [chemical binding]; other site 706191010518 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 706191010519 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 706191010520 Active Sites [active] 706191010521 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 706191010522 DksA-like zinc finger domain containing protein; Region: PHA00080 706191010523 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 706191010524 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 706191010525 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 706191010526 integrase; Provisional; Region: int; PHA02601 706191010527 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 706191010528 active site 706191010529 DNA binding site [nucleotide binding] 706191010530 Int/Topo IB signature motif; other site 706191010531 flavodoxin FldB; Provisional; Region: PRK12359 706191010532 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 706191010533 hypothetical protein; Provisional; Region: PRK10878 706191010534 putative global regulator; Reviewed; Region: PRK09559 706191010535 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 706191010536 hemolysin; Provisional; Region: PRK15087 706191010537 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 706191010538 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 706191010539 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 706191010540 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 706191010541 putative active site [active] 706191010542 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 706191010543 beta-galactosidase; Region: BGL; TIGR03356 706191010544 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 706191010545 classical (c) SDRs; Region: SDR_c; cd05233 706191010546 NAD(P) binding site [chemical binding]; other site 706191010547 active site 706191010548 glycine dehydrogenase; Provisional; Region: PRK05367 706191010549 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 706191010550 tetramer interface [polypeptide binding]; other site 706191010551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191010552 catalytic residue [active] 706191010553 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 706191010554 tetramer interface [polypeptide binding]; other site 706191010555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191010556 catalytic residue [active] 706191010557 glycine cleavage system protein H; Provisional; Region: PRK13380 706191010558 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 706191010559 lipoyl attachment site [posttranslational modification]; other site 706191010560 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 706191010561 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 706191010562 oxidoreductase; Provisional; Region: PRK08013 706191010563 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 706191010564 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 706191010565 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 706191010566 proline aminopeptidase P II; Provisional; Region: PRK10879 706191010567 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 706191010568 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 706191010569 active site 706191010570 hypothetical protein; Reviewed; Region: PRK01736 706191010571 Z-ring-associated protein; Provisional; Region: PRK10972 706191010572 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 706191010573 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 706191010574 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 706191010575 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 706191010576 ligand binding site [chemical binding]; other site 706191010577 NAD binding site [chemical binding]; other site 706191010578 tetramer interface [polypeptide binding]; other site 706191010579 catalytic site [active] 706191010580 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 706191010581 L-serine binding site [chemical binding]; other site 706191010582 ACT domain interface; other site 706191010583 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 706191010584 tetramer (dimer of dimers) interface [polypeptide binding]; other site 706191010585 active site 706191010586 dimer interface [polypeptide binding]; other site 706191010587 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 706191010588 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191010589 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 706191010590 putative dimerization interface [polypeptide binding]; other site 706191010591 oxidative stress defense protein; Provisional; Region: PRK11087 706191010592 Uncharacterized conserved protein [Function unknown]; Region: COG2968 706191010593 LysE type translocator; Region: LysE; cl00565 706191010594 mechanosensitive channel MscS; Provisional; Region: PRK10334 706191010595 Mechanosensitive ion channel; Region: MS_channel; pfam00924 706191010596 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 706191010597 dimer interface [polypeptide binding]; other site 706191010598 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 706191010599 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 706191010600 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 706191010601 active site 706191010602 intersubunit interface [polypeptide binding]; other site 706191010603 zinc binding site [ion binding]; other site 706191010604 Na+ binding site [ion binding]; other site 706191010605 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 706191010606 Phosphoglycerate kinase; Region: PGK; pfam00162 706191010607 substrate binding site [chemical binding]; other site 706191010608 hinge regions; other site 706191010609 ADP binding site [chemical binding]; other site 706191010610 catalytic site [active] 706191010611 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 706191010612 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 706191010613 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 706191010614 transketolase; Reviewed; Region: PRK12753 706191010615 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 706191010616 TPP-binding site [chemical binding]; other site 706191010617 dimer interface [polypeptide binding]; other site 706191010618 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 706191010619 PYR/PP interface [polypeptide binding]; other site 706191010620 dimer interface [polypeptide binding]; other site 706191010621 TPP binding site [chemical binding]; other site 706191010622 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 706191010623 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 706191010624 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 706191010625 agmatinase; Region: agmatinase; TIGR01230 706191010626 oligomer interface [polypeptide binding]; other site 706191010627 putative active site [active] 706191010628 Mn binding site [ion binding]; other site 706191010629 arginine decarboxylase; Provisional; Region: PRK05354 706191010630 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 706191010631 dimer interface [polypeptide binding]; other site 706191010632 active site 706191010633 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 706191010634 catalytic residues [active] 706191010635 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 706191010636 S-adenosylmethionine synthetase; Validated; Region: PRK05250 706191010637 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 706191010638 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 706191010639 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 706191010640 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 706191010641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191010642 putative substrate translocation pore; other site 706191010643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191010644 Cache domain; Region: Cache_1; pfam02743 706191010645 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706191010646 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191010647 dimer interface [polypeptide binding]; other site 706191010648 putative CheW interface [polypeptide binding]; other site 706191010649 hypothetical protein; Provisional; Region: PRK04860 706191010650 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 706191010651 DNA-specific endonuclease I; Provisional; Region: PRK15137 706191010652 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 706191010653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 706191010654 RNA methyltransferase, RsmE family; Region: TIGR00046 706191010655 glutathione synthetase; Provisional; Region: PRK05246 706191010656 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 706191010657 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 706191010658 hypothetical protein; Validated; Region: PRK00228 706191010659 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 706191010660 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 706191010661 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 706191010662 Walker A motif; other site 706191010663 ATP binding site [chemical binding]; other site 706191010664 Walker B motif; other site 706191010665 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 706191010666 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 706191010667 catalytic residue [active] 706191010668 YGGT family; Region: YGGT; pfam02325 706191010669 Predicted integral membrane protein [Function unknown]; Region: COG0762 706191010670 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 706191010671 active site 706191010672 dimerization interface [polypeptide binding]; other site 706191010673 HemN family oxidoreductase; Provisional; Region: PRK05660 706191010674 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706191010675 FeS/SAM binding site; other site 706191010676 HemN C-terminal domain; Region: HemN_C; pfam06969 706191010677 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 706191010678 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191010679 DNA-binding site [nucleotide binding]; DNA binding site 706191010680 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 706191010681 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 706191010682 active site 706191010683 phosphorylation site [posttranslational modification] 706191010684 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 706191010685 active site 706191010686 P-loop; other site 706191010687 phosphorylation site [posttranslational modification] 706191010688 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 706191010689 hypothetical protein; Provisional; Region: PRK10626 706191010690 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 706191010691 hypothetical protein; Provisional; Region: PRK11702 706191010692 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 706191010693 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 706191010694 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191010695 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191010696 alpha-galactosidase; Provisional; Region: PRK15076 706191010697 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 706191010698 NAD binding site [chemical binding]; other site 706191010699 sugar binding site [chemical binding]; other site 706191010700 divalent metal binding site [ion binding]; other site 706191010701 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 706191010702 dimer interface [polypeptide binding]; other site 706191010703 melibiose:sodium symporter; Provisional; Region: PRK10429 706191010704 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 706191010705 adenine DNA glycosylase; Provisional; Region: PRK10880 706191010706 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 706191010707 minor groove reading motif; other site 706191010708 helix-hairpin-helix signature motif; other site 706191010709 substrate binding pocket [chemical binding]; other site 706191010710 active site 706191010711 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 706191010712 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 706191010713 DNA binding and oxoG recognition site [nucleotide binding] 706191010714 oxidative damage protection protein; Provisional; Region: PRK05408 706191010715 murein transglycosylase C; Provisional; Region: mltC; PRK11671 706191010716 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 706191010717 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 706191010718 N-acetyl-D-glucosamine binding site [chemical binding]; other site 706191010719 catalytic residue [active] 706191010720 ornithine decarboxylase; Provisional; Region: PRK13578 706191010721 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 706191010722 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 706191010723 homodimer interface [polypeptide binding]; other site 706191010724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191010725 catalytic residue [active] 706191010726 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 706191010727 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 706191010728 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 706191010729 NADP binding site [chemical binding]; other site 706191010730 dimer interface [polypeptide binding]; other site 706191010731 Rdx family; Region: Rdx; cl01407 706191010732 Predicted transcriptional regulators [Transcription]; Region: COG1695 706191010733 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 706191010734 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 706191010735 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 706191010736 FAD binding pocket [chemical binding]; other site 706191010737 FAD binding motif [chemical binding]; other site 706191010738 phosphate binding motif [ion binding]; other site 706191010739 NAD binding pocket [chemical binding]; other site 706191010740 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 706191010741 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191010742 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 706191010743 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 706191010744 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 706191010745 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 706191010746 Predicted transcriptional regulators [Transcription]; Region: COG1733 706191010747 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 706191010748 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 706191010749 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 706191010750 NADP binding site [chemical binding]; other site 706191010751 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 706191010752 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 706191010753 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706191010754 putative DNA binding site [nucleotide binding]; other site 706191010755 dimerization interface [polypeptide binding]; other site 706191010756 putative Zn2+ binding site [ion binding]; other site 706191010757 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 706191010758 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 706191010759 trehalase; Provisional; Region: treF; PRK13270 706191010760 Trehalase; Region: Trehalase; cl17346 706191010761 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 706191010762 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 706191010763 dimerization interface [polypeptide binding]; other site 706191010764 metal binding site [ion binding]; metal-binding site 706191010765 General stress protein [General function prediction only]; Region: GsiB; COG3729 706191010766 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 706191010767 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 706191010768 TAP-like protein; Region: Abhydrolase_4; pfam08386 706191010769 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706191010770 putative active site [active] 706191010771 PAS fold; Region: PAS_3; pfam08447 706191010772 heme pocket [chemical binding]; other site 706191010773 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 706191010774 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706191010775 metal binding site [ion binding]; metal-binding site 706191010776 active site 706191010777 I-site; other site 706191010778 hypothetical protein; Provisional; Region: PRK10316 706191010779 YfdX protein; Region: YfdX; pfam10938 706191010780 CHASE3 domain; Region: CHASE3; pfam05227 706191010781 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706191010782 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191010783 dimer interface [polypeptide binding]; other site 706191010784 putative CheW interface [polypeptide binding]; other site 706191010785 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 706191010786 active site 706191010787 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706191010788 PAS domain; Region: PAS_9; pfam13426 706191010789 putative active site [active] 706191010790 heme pocket [chemical binding]; other site 706191010791 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706191010792 PAS domain; Region: PAS_9; pfam13426 706191010793 putative active site [active] 706191010794 heme pocket [chemical binding]; other site 706191010795 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 706191010796 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191010797 dimer interface [polypeptide binding]; other site 706191010798 putative CheW interface [polypeptide binding]; other site 706191010799 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706191010800 PAS domain; Region: PAS_9; pfam13426 706191010801 putative active site [active] 706191010802 heme pocket [chemical binding]; other site 706191010803 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706191010804 PAS domain; Region: PAS_9; pfam13426 706191010805 putative active site [active] 706191010806 heme pocket [chemical binding]; other site 706191010807 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 706191010808 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191010809 dimer interface [polypeptide binding]; other site 706191010810 putative CheW interface [polypeptide binding]; other site 706191010811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 706191010812 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 706191010813 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 706191010814 active site 706191010815 catalytic residues [active] 706191010816 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 706191010817 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 706191010818 Predicted transcriptional regulators [Transcription]; Region: COG1733 706191010819 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 706191010820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191010821 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706191010822 putative substrate translocation pore; other site 706191010823 EamA-like transporter family; Region: EamA; pfam00892 706191010824 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191010825 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191010826 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 706191010827 dimerization interface [polypeptide binding]; other site 706191010828 hypothetical protein; Provisional; Region: PRK07079 706191010829 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 706191010830 metal binding site [ion binding]; metal-binding site 706191010831 putative dimer interface [polypeptide binding]; other site 706191010832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191010833 metabolite-proton symporter; Region: 2A0106; TIGR00883 706191010834 putative substrate translocation pore; other site 706191010835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 706191010836 Integrase core domain; Region: rve_3; pfam13683 706191010837 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 706191010838 Integrase core domain; Region: rve_3; cl15866 706191010839 ATP-grasp domain; Region: ATP-grasp_4; cl17255 706191010840 Flavin Reductases; Region: FlaRed; cl00801 706191010841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191010842 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706191010843 putative substrate translocation pore; other site 706191010844 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 706191010845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191010846 Coenzyme A binding pocket [chemical binding]; other site 706191010847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191010848 S-adenosylmethionine binding site [chemical binding]; other site 706191010849 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 706191010850 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 706191010851 substrate binding site [chemical binding]; other site 706191010852 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 706191010853 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 706191010854 substrate binding site [chemical binding]; other site 706191010855 ligand binding site [chemical binding]; other site 706191010856 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 706191010857 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 706191010858 active site 706191010859 catalytic residues [active] 706191010860 metal binding site [ion binding]; metal-binding site 706191010861 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 706191010862 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 706191010863 active site 706191010864 non-prolyl cis peptide bond; other site 706191010865 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 706191010866 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 706191010867 tetramer interface [polypeptide binding]; other site 706191010868 active site 706191010869 Mg2+/Mn2+ binding site [ion binding]; other site 706191010870 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 706191010871 FOG: CBS domain [General function prediction only]; Region: COG0517 706191010872 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 706191010873 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 706191010874 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 706191010875 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706191010876 metal binding site [ion binding]; metal-binding site 706191010877 active site 706191010878 I-site; other site 706191010879 penicillin-binding protein 2; Provisional; Region: PRK10795 706191010880 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 706191010881 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 706191010882 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 706191010883 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 706191010884 phosphopentomutase; Provisional; Region: PRK05362 706191010885 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 706191010886 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 706191010887 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 706191010888 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 706191010889 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 706191010890 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 706191010891 intersubunit interface [polypeptide binding]; other site 706191010892 active site 706191010893 catalytic residue [active] 706191010894 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 706191010895 active site 706191010896 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 706191010897 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 706191010898 active site 706191010899 nucleophile elbow; other site 706191010900 periplasmic protein; Provisional; Region: PRK10568 706191010901 BON domain; Region: BON; cl02771 706191010902 BON domain; Region: BON; pfam04972 706191010903 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 706191010904 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 706191010905 G1 box; other site 706191010906 putative GEF interaction site [polypeptide binding]; other site 706191010907 GTP/Mg2+ binding site [chemical binding]; other site 706191010908 Switch I region; other site 706191010909 G2 box; other site 706191010910 G3 box; other site 706191010911 Switch II region; other site 706191010912 G4 box; other site 706191010913 G5 box; other site 706191010914 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 706191010915 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 706191010916 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 706191010917 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 706191010918 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 706191010919 Ferritin-like domain; Region: Ferritin; pfam00210 706191010920 ferroxidase diiron center [ion binding]; other site 706191010921 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 706191010922 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 706191010923 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 706191010924 putative active site [active] 706191010925 putative catalytic site [active] 706191010926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191010927 D-galactonate transporter; Region: 2A0114; TIGR00893 706191010928 putative substrate translocation pore; other site 706191010929 Transcriptional regulators [Transcription]; Region: PurR; COG1609 706191010930 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191010931 DNA binding site [nucleotide binding] 706191010932 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 706191010933 ligand binding site [chemical binding]; other site 706191010934 dimerization interface [polypeptide binding]; other site 706191010935 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 706191010936 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 706191010937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191010938 dimer interface [polypeptide binding]; other site 706191010939 conserved gate region; other site 706191010940 putative PBP binding loops; other site 706191010941 ABC-ATPase subunit interface; other site 706191010942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191010943 dimer interface [polypeptide binding]; other site 706191010944 conserved gate region; other site 706191010945 putative PBP binding loops; other site 706191010946 ABC-ATPase subunit interface; other site 706191010947 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 706191010948 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 706191010949 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 706191010950 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191010951 Walker A/P-loop; other site 706191010952 ATP binding site [chemical binding]; other site 706191010953 Q-loop/lid; other site 706191010954 ABC transporter signature motif; other site 706191010955 Walker B; other site 706191010956 D-loop; other site 706191010957 H-loop/switch region; other site 706191010958 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 706191010959 putative acyl-acceptor binding pocket; other site 706191010960 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 706191010961 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 706191010962 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191010963 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 706191010964 substrate binding pocket [chemical binding]; other site 706191010965 membrane-bound complex binding site; other site 706191010966 hinge residues; other site 706191010967 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 706191010968 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 706191010969 Walker A/P-loop; other site 706191010970 ATP binding site [chemical binding]; other site 706191010971 Q-loop/lid; other site 706191010972 ABC transporter signature motif; other site 706191010973 Walker B; other site 706191010974 D-loop; other site 706191010975 H-loop/switch region; other site 706191010976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191010977 dimer interface [polypeptide binding]; other site 706191010978 conserved gate region; other site 706191010979 putative PBP binding loops; other site 706191010980 ABC-ATPase subunit interface; other site 706191010981 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 706191010982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191010983 Coenzyme A binding pocket [chemical binding]; other site 706191010984 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 706191010985 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191010986 substrate binding pocket [chemical binding]; other site 706191010987 membrane-bound complex binding site; other site 706191010988 hinge residues; other site 706191010989 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 706191010990 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 706191010991 active site 706191010992 non-prolyl cis peptide bond; other site 706191010993 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 706191010994 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 706191010995 metal binding site [ion binding]; metal-binding site 706191010996 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 706191010997 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 706191010998 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 706191010999 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 706191011000 metal binding site [ion binding]; metal-binding site 706191011001 dimer interface [polypeptide binding]; other site 706191011002 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 706191011003 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 706191011004 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 706191011005 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 706191011006 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 706191011007 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 706191011008 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706191011009 metal binding site [ion binding]; metal-binding site 706191011010 active site 706191011011 I-site; other site 706191011012 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 706191011013 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 706191011014 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191011015 DNA-binding site [nucleotide binding]; DNA binding site 706191011016 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706191011017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191011018 homodimer interface [polypeptide binding]; other site 706191011019 catalytic residue [active] 706191011020 Spore Coat Protein U domain; Region: SCPU; pfam05229 706191011021 Spore Coat Protein U domain; Region: SCPU; pfam05229 706191011022 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 706191011023 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 706191011024 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 706191011025 PapC N-terminal domain; Region: PapC_N; pfam13954 706191011026 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 706191011027 PapC C-terminal domain; Region: PapC_C; pfam13953 706191011028 Spore Coat Protein U domain; Region: SCPU; cl02253 706191011029 Spore Coat Protein U domain; Region: SCPU; pfam05229 706191011030 citrate-proton symporter; Provisional; Region: PRK15075 706191011031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191011032 putative substrate translocation pore; other site 706191011033 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 706191011034 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 706191011035 biopolymer transport protein ExbB; Provisional; Region: PRK10414 706191011036 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 706191011037 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 706191011038 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 706191011039 active site turn [active] 706191011040 phosphorylation site [posttranslational modification] 706191011041 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 706191011042 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191011043 DNA binding site [nucleotide binding] 706191011044 domain linker motif; other site 706191011045 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706191011046 benzoate transport; Region: 2A0115; TIGR00895 706191011047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191011048 putative substrate translocation pore; other site 706191011049 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 706191011050 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 706191011051 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 706191011052 dimer interface [polypeptide binding]; other site 706191011053 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 706191011054 active site 706191011055 Fe binding site [ion binding]; other site 706191011056 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 706191011057 heterodimer interface [polypeptide binding]; other site 706191011058 multimer interface [polypeptide binding]; other site 706191011059 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 706191011060 active site 706191011061 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 706191011062 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 706191011063 heterodimer interface [polypeptide binding]; other site 706191011064 active site 706191011065 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 706191011066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191011067 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 706191011068 dimerization interface [polypeptide binding]; other site 706191011069 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 706191011070 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 706191011071 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 706191011072 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 706191011073 tetramer interface [polypeptide binding]; other site 706191011074 active site 706191011075 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 706191011076 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 706191011077 dimer interface [polypeptide binding]; other site 706191011078 active site 706191011079 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 706191011080 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 706191011081 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 706191011082 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 706191011083 Bacterial transcriptional regulator; Region: IclR; pfam01614 706191011084 cystathionine beta-lyase; Provisional; Region: PRK08114 706191011085 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 706191011086 homodimer interface [polypeptide binding]; other site 706191011087 substrate-cofactor binding pocket; other site 706191011088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191011089 catalytic residue [active] 706191011090 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 706191011091 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 706191011092 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 706191011093 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 706191011094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191011095 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191011096 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 706191011097 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 706191011098 active site 706191011099 catalytic tetrad [active] 706191011100 flagellin; Provisional; Region: PRK12802 706191011101 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 706191011102 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 706191011103 FtsI repressor; Provisional; Region: PRK10883 706191011104 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 706191011105 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 706191011106 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 706191011107 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 706191011108 putative acyl-acceptor binding pocket; other site 706191011109 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 706191011110 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 706191011111 CAP-like domain; other site 706191011112 active site 706191011113 primary dimer interface [polypeptide binding]; other site 706191011114 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 706191011115 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 706191011116 PRD domain; Region: PRD; pfam00874 706191011117 PRD domain; Region: PRD; pfam00874 706191011118 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 706191011119 active site 706191011120 P-loop; other site 706191011121 phosphorylation site [posttranslational modification] 706191011122 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 706191011123 active site 706191011124 phosphorylation site [posttranslational modification] 706191011125 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 706191011126 active site 706191011127 P-loop; other site 706191011128 phosphorylation site [posttranslational modification] 706191011129 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 706191011130 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 706191011131 intersubunit interface [polypeptide binding]; other site 706191011132 active site 706191011133 zinc binding site [ion binding]; other site 706191011134 Na+ binding site [ion binding]; other site 706191011135 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 706191011136 intersubunit interface [polypeptide binding]; other site 706191011137 active site 706191011138 zinc binding site [ion binding]; other site 706191011139 Na+ binding site [ion binding]; other site 706191011140 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 706191011141 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191011142 substrate binding pocket [chemical binding]; other site 706191011143 membrane-bound complex binding site; other site 706191011144 hinge residues; other site 706191011145 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 706191011146 Uncharacterized conserved protein [Function unknown]; Region: COG1359 706191011147 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 706191011148 anchoring element; other site 706191011149 dimer interface [polypeptide binding]; other site 706191011150 ATP binding site [chemical binding]; other site 706191011151 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 706191011152 active site 706191011153 metal binding site [ion binding]; metal-binding site 706191011154 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 706191011155 esterase YqiA; Provisional; Region: PRK11071 706191011156 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 706191011157 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 706191011158 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 706191011159 active site 706191011160 metal binding site [ion binding]; metal-binding site 706191011161 hexamer interface [polypeptide binding]; other site 706191011162 putative dehydrogenase; Provisional; Region: PRK11039 706191011163 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 706191011164 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 706191011165 dimer interface [polypeptide binding]; other site 706191011166 ADP-ribose binding site [chemical binding]; other site 706191011167 active site 706191011168 nudix motif; other site 706191011169 metal binding site [ion binding]; metal-binding site 706191011170 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 706191011171 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 706191011172 hypothetical protein; Provisional; Region: PRK11653 706191011173 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 706191011174 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 706191011175 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 706191011176 putative active site [active] 706191011177 metal binding site [ion binding]; metal-binding site 706191011178 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 706191011179 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 706191011180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 706191011181 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 706191011182 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 706191011183 putative ribose interaction site [chemical binding]; other site 706191011184 putative ADP binding site [chemical binding]; other site 706191011185 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 706191011186 active site 706191011187 nucleotide binding site [chemical binding]; other site 706191011188 HIGH motif; other site 706191011189 KMSKS motif; other site 706191011190 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 706191011191 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 706191011192 metal binding triad; other site 706191011193 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 706191011194 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 706191011195 metal binding triad; other site 706191011196 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 706191011197 Uncharacterized conserved protein [Function unknown]; Region: COG3025 706191011198 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 706191011199 putative active site [active] 706191011200 putative metal binding residues [ion binding]; other site 706191011201 signature motif; other site 706191011202 putative triphosphate binding site [ion binding]; other site 706191011203 SH3 domain-containing protein; Provisional; Region: PRK10884 706191011204 Bacterial SH3 domain homologues; Region: SH3b; smart00287 706191011205 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 706191011206 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 706191011207 active site 706191011208 NTP binding site [chemical binding]; other site 706191011209 metal binding triad [ion binding]; metal-binding site 706191011210 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 706191011211 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706191011212 Zn2+ binding site [ion binding]; other site 706191011213 Mg2+ binding site [ion binding]; other site 706191011214 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 706191011215 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 706191011216 homooctamer interface [polypeptide binding]; other site 706191011217 active site 706191011218 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 706191011219 UGMP family protein; Validated; Region: PRK09604 706191011220 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 706191011221 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 706191011222 DNA primase; Validated; Region: dnaG; PRK05667 706191011223 CHC2 zinc finger; Region: zf-CHC2; pfam01807 706191011224 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 706191011225 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 706191011226 active site 706191011227 metal binding site [ion binding]; metal-binding site 706191011228 interdomain interaction site; other site 706191011229 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 706191011230 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 706191011231 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 706191011232 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 706191011233 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 706191011234 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 706191011235 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706191011236 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 706191011237 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 706191011238 DNA binding residues [nucleotide binding] 706191011239 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 706191011240 active site 706191011241 SUMO-1 interface [polypeptide binding]; other site 706191011242 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 706191011243 active site 706191011244 Int/Topo IB signature motif; other site 706191011245 DNA binding site [nucleotide binding] 706191011246 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 706191011247 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 706191011248 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 706191011249 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 706191011250 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 706191011251 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 706191011252 Phage tail tube protein FII; Region: Phage_tube; cl01390 706191011253 major tail sheath protein; Provisional; Region: FI; PHA02560 706191011254 YCII-related domain; Region: YCII; cl00999 706191011255 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 706191011256 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 706191011257 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 706191011258 baseplate assembly protein; Provisional; Region: J; PHA02568 706191011259 baseplate wedge subunit; Provisional; Region: W; PHA02516 706191011260 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 706191011261 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 706191011262 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 706191011263 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 706191011264 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 706191011265 catalytic residues [active] 706191011266 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 706191011267 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 706191011268 DksA-like zinc finger domain containing protein; Region: PHA00080 706191011269 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 706191011270 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 706191011271 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 706191011272 active site 706191011273 intersubunit interface [polypeptide binding]; other site 706191011274 zinc binding site [ion binding]; other site 706191011275 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 706191011276 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 706191011277 active site 706191011278 P-loop; other site 706191011279 phosphorylation site [posttranslational modification] 706191011280 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 706191011281 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 706191011282 active site 706191011283 phosphorylation site [posttranslational modification] 706191011284 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 706191011285 HTH domain; Region: HTH_11; pfam08279 706191011286 Mga helix-turn-helix domain; Region: Mga; pfam05043 706191011287 PRD domain; Region: PRD; pfam00874 706191011288 PRD domain; Region: PRD; pfam00874 706191011289 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 706191011290 active site 706191011291 P-loop; other site 706191011292 phosphorylation site [posttranslational modification] 706191011293 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 706191011294 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 706191011295 Sulfate transporter family; Region: Sulfate_transp; pfam00916 706191011296 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 706191011297 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 706191011298 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191011299 dimer interface [polypeptide binding]; other site 706191011300 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 706191011301 putative CheW interface [polypeptide binding]; other site 706191011302 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706191011303 dimerization interface [polypeptide binding]; other site 706191011304 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706191011305 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191011306 dimer interface [polypeptide binding]; other site 706191011307 putative CheW interface [polypeptide binding]; other site 706191011308 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 706191011309 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 706191011310 GAF domain; Region: GAF; pfam01590 706191011311 PAS domain S-box; Region: sensory_box; TIGR00229 706191011312 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706191011313 putative active site [active] 706191011314 heme pocket [chemical binding]; other site 706191011315 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 706191011316 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706191011317 metal binding site [ion binding]; metal-binding site 706191011318 active site 706191011319 I-site; other site 706191011320 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 706191011321 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 706191011322 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706191011323 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191011324 dimer interface [polypeptide binding]; other site 706191011325 putative CheW interface [polypeptide binding]; other site 706191011326 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 706191011327 GAF domain; Region: GAF; pfam01590 706191011328 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 706191011329 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 706191011330 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 706191011331 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706191011332 metal binding site [ion binding]; metal-binding site 706191011333 active site 706191011334 I-site; other site 706191011335 anti-RssB factor; Provisional; Region: PRK10244 706191011336 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 706191011337 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 706191011338 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 706191011339 MASE1; Region: MASE1; cl17823 706191011340 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 706191011341 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706191011342 metal binding site [ion binding]; metal-binding site 706191011343 active site 706191011344 I-site; other site 706191011345 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 706191011346 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 706191011347 Sulfate transporter family; Region: Sulfate_transp; pfam00916 706191011348 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 706191011349 active site clefts [active] 706191011350 zinc binding site [ion binding]; other site 706191011351 dimer interface [polypeptide binding]; other site 706191011352 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191011353 active site 706191011354 motif I; other site 706191011355 motif II; other site 706191011356 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 706191011357 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 706191011358 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 706191011359 active site 706191011360 FMN binding site [chemical binding]; other site 706191011361 2,4-decadienoyl-CoA binding site; other site 706191011362 catalytic residue [active] 706191011363 4Fe-4S cluster binding site [ion binding]; other site 706191011364 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 706191011365 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706191011366 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 706191011367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191011368 S-adenosylmethionine binding site [chemical binding]; other site 706191011369 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 706191011370 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 706191011371 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 706191011372 Cl- selectivity filter; other site 706191011373 Cl- binding residues [ion binding]; other site 706191011374 pore gating glutamate residue; other site 706191011375 dimer interface [polypeptide binding]; other site 706191011376 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 706191011377 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 706191011378 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 706191011379 YybP-YkoY leader RNA element; PANA_ncRNA11 706191011380 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 706191011381 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 706191011382 galactarate dehydratase; Region: galactar-dH20; TIGR03248 706191011383 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 706191011384 altronate oxidoreductase; Provisional; Region: PRK03643 706191011385 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 706191011386 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 706191011387 Glucuronate isomerase; Region: UxaC; pfam02614 706191011388 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 706191011389 D-galactonate transporter; Region: 2A0114; TIGR00893 706191011390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191011391 putative substrate translocation pore; other site 706191011392 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 706191011393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191011394 DNA-binding site [nucleotide binding]; DNA binding site 706191011395 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 706191011396 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 706191011397 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 706191011398 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 706191011399 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 706191011400 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 706191011401 Predicted membrane protein [Function unknown]; Region: COG5393 706191011402 YqjK-like protein; Region: YqjK; pfam13997 706191011403 Predicted membrane protein [Function unknown]; Region: COG2259 706191011404 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 706191011405 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 706191011406 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 706191011407 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 706191011408 active site 706191011409 substrate binding site [chemical binding]; other site 706191011410 cosubstrate binding site; other site 706191011411 catalytic site [active] 706191011412 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 706191011413 active site 706191011414 hexamer interface [polypeptide binding]; other site 706191011415 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 706191011416 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 706191011417 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 706191011418 putative dimer interface [polypeptide binding]; other site 706191011419 N-terminal domain interface [polypeptide binding]; other site 706191011420 putative substrate binding pocket (H-site) [chemical binding]; other site 706191011421 threonine/serine transporter TdcC; Provisional; Region: PRK13629 706191011422 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 706191011423 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 706191011424 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 706191011425 tetramer interface [polypeptide binding]; other site 706191011426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191011427 catalytic residue [active] 706191011428 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 706191011429 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 706191011430 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 706191011431 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 706191011432 putative SAM binding site [chemical binding]; other site 706191011433 putative homodimer interface [polypeptide binding]; other site 706191011434 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 706191011435 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 706191011436 putative ligand binding site [chemical binding]; other site 706191011437 hypothetical protein; Reviewed; Region: PRK12497 706191011438 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 706191011439 dimer interface [polypeptide binding]; other site 706191011440 active site 706191011441 outer membrane lipoprotein; Provisional; Region: PRK11023 706191011442 BON domain; Region: BON; pfam04972 706191011443 BON domain; Region: BON; pfam04972 706191011444 Pirin-related protein [General function prediction only]; Region: COG1741 706191011445 Pirin; Region: Pirin; pfam02678 706191011446 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191011447 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 706191011448 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 706191011449 dimerization interface [polypeptide binding]; other site 706191011450 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 706191011451 HTH domain; Region: HTH_11; pfam08279 706191011452 Mga helix-turn-helix domain; Region: Mga; pfam05043 706191011453 PRD domain; Region: PRD; pfam00874 706191011454 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 706191011455 active site 706191011456 P-loop; other site 706191011457 phosphorylation site [posttranslational modification] 706191011458 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 706191011459 active site 706191011460 phosphorylation site [posttranslational modification] 706191011461 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 706191011462 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 706191011463 catalytic residue [active] 706191011464 dihydroorotase; Provisional; Region: PRK09237 706191011465 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 706191011466 active site 706191011467 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 706191011468 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 706191011469 Domain of unknown function (DUF4312); Region: DUF4312; pfam14189 706191011470 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 706191011471 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 706191011472 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 706191011473 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 706191011474 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 706191011475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191011476 putative substrate translocation pore; other site 706191011477 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 706191011478 alpha-glucosidase; Provisional; Region: PRK10426 706191011479 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 706191011480 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 706191011481 putative active site [active] 706191011482 putative catalytic site [active] 706191011483 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 706191011484 active site 706191011485 catalytic residues [active] 706191011486 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 706191011487 dimerization interface [polypeptide binding]; other site 706191011488 putative active cleft [active] 706191011489 Class I aldolases; Region: Aldolase_Class_I; cl17187 706191011490 catalytic residue [active] 706191011491 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 706191011492 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 706191011493 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 706191011494 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 706191011495 substrate binding site [chemical binding]; other site 706191011496 ATP binding site [chemical binding]; other site 706191011497 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 706191011498 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 706191011499 putative DNA binding site [nucleotide binding]; other site 706191011500 putative Zn2+ binding site [ion binding]; other site 706191011501 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 706191011502 Cytochrome b562; Region: Cytochrom_B562; cl01546 706191011503 peptidase PmbA; Provisional; Region: PRK11040 706191011504 hypothetical protein; Provisional; Region: PRK05255 706191011505 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 706191011506 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 706191011507 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 706191011508 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 706191011509 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 706191011510 AMP binding site [chemical binding]; other site 706191011511 metal binding site [ion binding]; metal-binding site 706191011512 active site 706191011513 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 706191011514 dimer interface [polypeptide binding]; other site 706191011515 ligand binding site [chemical binding]; other site 706191011516 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706191011517 dimerization interface [polypeptide binding]; other site 706191011518 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706191011519 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191011520 dimer interface [polypeptide binding]; other site 706191011521 putative CheW interface [polypeptide binding]; other site 706191011522 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 706191011523 Predicted membrane protein [Function unknown]; Region: COG2707 706191011524 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 706191011525 dimer interface [polypeptide binding]; other site 706191011526 substrate binding site [chemical binding]; other site 706191011527 metal binding sites [ion binding]; metal-binding site 706191011528 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 706191011529 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 706191011530 putative active site pocket [active] 706191011531 dimerization interface [polypeptide binding]; other site 706191011532 putative catalytic residue [active] 706191011533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 706191011534 Family of unknown function (DUF490); Region: DUF490; pfam04357 706191011535 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 706191011536 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 706191011537 Surface antigen; Region: Bac_surface_Ag; pfam01103 706191011538 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 706191011539 Domain of unknown function DUF21; Region: DUF21; pfam01595 706191011540 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 706191011541 Transporter associated domain; Region: CorC_HlyC; smart01091 706191011542 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 706191011543 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 706191011544 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 706191011545 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 706191011546 active site 706191011547 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 706191011548 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 706191011549 active site 706191011550 metal binding site [ion binding]; metal-binding site 706191011551 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 706191011552 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 706191011553 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 706191011554 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 706191011555 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 706191011556 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 706191011557 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 706191011558 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 706191011559 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 706191011560 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 706191011561 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 706191011562 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 706191011563 dimer interface [polypeptide binding]; other site 706191011564 ssDNA binding site [nucleotide binding]; other site 706191011565 tetramer (dimer of dimers) interface [polypeptide binding]; other site 706191011566 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 706191011567 esterase; Provisional; Region: PRK10566 706191011568 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 706191011569 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706191011570 dimerization interface [polypeptide binding]; other site 706191011571 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706191011572 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191011573 dimer interface [polypeptide binding]; other site 706191011574 putative CheW interface [polypeptide binding]; other site 706191011575 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 706191011576 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 706191011577 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 706191011578 active site 706191011579 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 706191011580 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 706191011581 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 706191011582 exoribonuclease R; Provisional; Region: PRK11642 706191011583 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 706191011584 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 706191011585 RNB domain; Region: RNB; pfam00773 706191011586 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 706191011587 RNA binding site [nucleotide binding]; other site 706191011588 transcriptional repressor NsrR; Provisional; Region: PRK11014 706191011589 Rrf2 family protein; Region: rrf2_super; TIGR00738 706191011590 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 706191011591 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 706191011592 GDP-binding site [chemical binding]; other site 706191011593 ACT binding site; other site 706191011594 IMP binding site; other site 706191011595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 706191011596 FtsH protease regulator HflC; Provisional; Region: PRK11029 706191011597 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 706191011598 FtsH protease regulator HflK; Provisional; Region: PRK10930 706191011599 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 706191011600 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 706191011601 GTPase HflX; Provisional; Region: PRK11058 706191011602 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 706191011603 HflX GTPase family; Region: HflX; cd01878 706191011604 G1 box; other site 706191011605 GTP/Mg2+ binding site [chemical binding]; other site 706191011606 Switch I region; other site 706191011607 G2 box; other site 706191011608 G3 box; other site 706191011609 Switch II region; other site 706191011610 G4 box; other site 706191011611 G5 box; other site 706191011612 bacterial Hfq-like; Region: Hfq; cd01716 706191011613 hexamer interface [polypeptide binding]; other site 706191011614 Sm1 motif; other site 706191011615 RNA binding site [nucleotide binding]; other site 706191011616 Sm2 motif; other site 706191011617 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 706191011618 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 706191011619 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 706191011620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191011621 ATP binding site [chemical binding]; other site 706191011622 Mg2+ binding site [ion binding]; other site 706191011623 G-X-G motif; other site 706191011624 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 706191011625 ATP binding site [chemical binding]; other site 706191011626 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 706191011627 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 706191011628 AMIN domain; Region: AMIN; pfam11741 706191011629 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 706191011630 active site 706191011631 metal binding site [ion binding]; metal-binding site 706191011632 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 706191011633 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 706191011634 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 706191011635 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 706191011636 putative carbohydrate kinase; Provisional; Region: PRK10565 706191011637 Uncharacterized conserved protein [Function unknown]; Region: COG0062 706191011638 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 706191011639 putative substrate binding site [chemical binding]; other site 706191011640 putative ATP binding site [chemical binding]; other site 706191011641 epoxyqueuosine reductase; Region: TIGR00276 706191011642 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 706191011643 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 706191011644 catalytic site [active] 706191011645 putative active site [active] 706191011646 putative substrate binding site [chemical binding]; other site 706191011647 dimer interface [polypeptide binding]; other site 706191011648 GTPase RsgA; Reviewed; Region: PRK12288 706191011649 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 706191011650 RNA binding site [nucleotide binding]; other site 706191011651 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 706191011652 GTPase/Zn-binding domain interface [polypeptide binding]; other site 706191011653 GTP/Mg2+ binding site [chemical binding]; other site 706191011654 G4 box; other site 706191011655 G5 box; other site 706191011656 G1 box; other site 706191011657 Switch I region; other site 706191011658 G2 box; other site 706191011659 G3 box; other site 706191011660 Switch II region; other site 706191011661 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 706191011662 putative mechanosensitive channel protein; Provisional; Region: PRK10929 706191011663 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 706191011664 Mechanosensitive ion channel; Region: MS_channel; pfam00924 706191011665 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 706191011666 arginine repressor; Provisional; Region: PRK05066 706191011667 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 706191011668 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 706191011669 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 706191011670 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 706191011671 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 706191011672 putative transposase; Provisional; Region: PRK09857 706191011673 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 706191011674 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 706191011675 succinic semialdehyde dehydrogenase; Region: PLN02278 706191011676 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 706191011677 tetramerization interface [polypeptide binding]; other site 706191011678 NAD(P) binding site [chemical binding]; other site 706191011679 catalytic residues [active] 706191011680 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 706191011681 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 706191011682 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 706191011683 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706191011684 HlyD family secretion protein; Region: HlyD_3; pfam13437 706191011685 efflux system membrane protein; Provisional; Region: PRK11594 706191011686 transcriptional regulator; Provisional; Region: PRK10632 706191011687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191011688 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 706191011689 putative effector binding pocket; other site 706191011690 dimerization interface [polypeptide binding]; other site 706191011691 protease TldD; Provisional; Region: tldD; PRK10735 706191011692 hypothetical protein; Provisional; Region: PRK10899 706191011693 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 706191011694 ribonuclease G; Provisional; Region: PRK11712 706191011695 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 706191011696 homodimer interface [polypeptide binding]; other site 706191011697 oligonucleotide binding site [chemical binding]; other site 706191011698 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 706191011699 dimer interface [polypeptide binding]; other site 706191011700 rod shape-determining protein MreD; Provisional; Region: PRK11060 706191011701 rod shape-determining protein MreC; Region: mreC; TIGR00219 706191011702 rod shape-determining protein MreC; Region: MreC; pfam04085 706191011703 rod shape-determining protein MreB; Provisional; Region: PRK13927 706191011704 MreB and similar proteins; Region: MreB_like; cd10225 706191011705 nucleotide binding site [chemical binding]; other site 706191011706 Mg binding site [ion binding]; other site 706191011707 putative protofilament interaction site [polypeptide binding]; other site 706191011708 RodZ interaction site [polypeptide binding]; other site 706191011709 regulatory protein CsrD; Provisional; Region: PRK11059 706191011710 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706191011711 active site 706191011712 I-site; other site 706191011713 metal binding site [ion binding]; metal-binding site 706191011714 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 706191011715 TMAO/DMSO reductase; Reviewed; Region: PRK05363 706191011716 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 706191011717 Moco binding site; other site 706191011718 metal coordination site [ion binding]; other site 706191011719 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 706191011720 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 706191011721 Dehydroquinase class II; Region: DHquinase_II; pfam01220 706191011722 active site 706191011723 trimer interface [polypeptide binding]; other site 706191011724 dimer interface [polypeptide binding]; other site 706191011725 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 706191011726 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 706191011727 carboxyltransferase (CT) interaction site; other site 706191011728 biotinylation site [posttranslational modification]; other site 706191011729 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 706191011730 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 706191011731 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 706191011732 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 706191011733 hypothetical protein; Provisional; Region: PRK10633 706191011734 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 706191011735 Na binding site [ion binding]; other site 706191011736 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 706191011737 Methyltransferase domain; Region: Methyltransf_18; pfam12847 706191011738 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 706191011739 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 706191011740 FMN binding site [chemical binding]; other site 706191011741 active site 706191011742 catalytic residues [active] 706191011743 substrate binding site [chemical binding]; other site 706191011744 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 706191011745 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 706191011746 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191011747 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 706191011748 substrate binding pocket [chemical binding]; other site 706191011749 membrane-bound complex binding site; other site 706191011750 hinge residues; other site 706191011751 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 706191011752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191011753 conserved gate region; other site 706191011754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191011755 ABC-ATPase subunit interface; other site 706191011756 putative PBP binding loops; other site 706191011757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191011758 dimer interface [polypeptide binding]; other site 706191011759 conserved gate region; other site 706191011760 putative PBP binding loops; other site 706191011761 ABC-ATPase subunit interface; other site 706191011762 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 706191011763 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 706191011764 Walker A/P-loop; other site 706191011765 ATP binding site [chemical binding]; other site 706191011766 Q-loop/lid; other site 706191011767 ABC transporter signature motif; other site 706191011768 Walker B; other site 706191011769 D-loop; other site 706191011770 H-loop/switch region; other site 706191011771 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 706191011772 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 706191011773 trimer interface [polypeptide binding]; other site 706191011774 putative metal binding site [ion binding]; other site 706191011775 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 706191011776 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 706191011777 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 706191011778 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 706191011779 shikimate binding site; other site 706191011780 NAD(P) binding site [chemical binding]; other site 706191011781 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 706191011782 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 706191011783 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 706191011784 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 706191011785 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 706191011786 hypothetical protein; Validated; Region: PRK03430 706191011787 hypothetical protein; Provisional; Region: PRK10736 706191011788 DNA protecting protein DprA; Region: dprA; TIGR00732 706191011789 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 706191011790 active site 706191011791 catalytic residues [active] 706191011792 metal binding site [ion binding]; metal-binding site 706191011793 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 706191011794 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 706191011795 putative active site [active] 706191011796 substrate binding site [chemical binding]; other site 706191011797 putative cosubstrate binding site; other site 706191011798 catalytic site [active] 706191011799 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 706191011800 substrate binding site [chemical binding]; other site 706191011801 16S rRNA methyltransferase B; Provisional; Region: PRK10901 706191011802 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 706191011803 putative RNA binding site [nucleotide binding]; other site 706191011804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191011805 S-adenosylmethionine binding site [chemical binding]; other site 706191011806 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 706191011807 TrkA-N domain; Region: TrkA_N; pfam02254 706191011808 TrkA-C domain; Region: TrkA_C; pfam02080 706191011809 TrkA-N domain; Region: TrkA_N; pfam02254 706191011810 TrkA-C domain; Region: TrkA_C; pfam02080 706191011811 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 706191011812 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 706191011813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 706191011814 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 706191011815 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 706191011816 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 706191011817 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 706191011818 alphaNTD homodimer interface [polypeptide binding]; other site 706191011819 alphaNTD - beta interaction site [polypeptide binding]; other site 706191011820 alphaNTD - beta' interaction site [polypeptide binding]; other site 706191011821 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 706191011822 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 706191011823 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 706191011824 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 706191011825 RNA binding surface [nucleotide binding]; other site 706191011826 30S ribosomal protein S11; Validated; Region: PRK05309 706191011827 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 706191011828 30S ribosomal protein S13; Region: bact_S13; TIGR03631 706191011829 Alpha operon ribosome binding site; PANA_ncRNA27 706191011830 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 706191011831 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 706191011832 SecY translocase; Region: SecY; pfam00344 706191011833 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 706191011834 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 706191011835 23S rRNA binding site [nucleotide binding]; other site 706191011836 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 706191011837 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 706191011838 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 706191011839 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 706191011840 23S rRNA interface [nucleotide binding]; other site 706191011841 5S rRNA interface [nucleotide binding]; other site 706191011842 L27 interface [polypeptide binding]; other site 706191011843 L5 interface [polypeptide binding]; other site 706191011844 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 706191011845 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 706191011846 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 706191011847 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 706191011848 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 706191011849 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 706191011850 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 706191011851 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 706191011852 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 706191011853 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 706191011854 RNA binding site [nucleotide binding]; other site 706191011855 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 706191011856 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 706191011857 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 706191011858 23S rRNA interface [nucleotide binding]; other site 706191011859 putative translocon interaction site; other site 706191011860 signal recognition particle (SRP54) interaction site; other site 706191011861 L23 interface [polypeptide binding]; other site 706191011862 trigger factor interaction site; other site 706191011863 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 706191011864 23S rRNA interface [nucleotide binding]; other site 706191011865 5S rRNA interface [nucleotide binding]; other site 706191011866 putative antibiotic binding site [chemical binding]; other site 706191011867 L25 interface [polypeptide binding]; other site 706191011868 L27 interface [polypeptide binding]; other site 706191011869 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 706191011870 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 706191011871 G-X-X-G motif; other site 706191011872 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 706191011873 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 706191011874 protein-rRNA interface [nucleotide binding]; other site 706191011875 putative translocon binding site; other site 706191011876 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 706191011877 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 706191011878 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 706191011879 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 706191011880 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 706191011881 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 706191011882 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 706191011883 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 706191011884 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 706191011885 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 706191011886 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 706191011887 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 706191011888 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 706191011889 heme binding site [chemical binding]; other site 706191011890 ferroxidase pore; other site 706191011891 ferroxidase diiron center [ion binding]; other site 706191011892 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 706191011893 elongation factor Tu; Reviewed; Region: PRK00049 706191011894 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 706191011895 G1 box; other site 706191011896 GEF interaction site [polypeptide binding]; other site 706191011897 GTP/Mg2+ binding site [chemical binding]; other site 706191011898 Switch I region; other site 706191011899 G2 box; other site 706191011900 G3 box; other site 706191011901 Switch II region; other site 706191011902 G4 box; other site 706191011903 G5 box; other site 706191011904 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 706191011905 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 706191011906 Antibiotic Binding Site [chemical binding]; other site 706191011907 elongation factor G; Reviewed; Region: PRK00007 706191011908 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 706191011909 G1 box; other site 706191011910 putative GEF interaction site [polypeptide binding]; other site 706191011911 GTP/Mg2+ binding site [chemical binding]; other site 706191011912 Switch I region; other site 706191011913 G2 box; other site 706191011914 G3 box; other site 706191011915 Switch II region; other site 706191011916 G4 box; other site 706191011917 G5 box; other site 706191011918 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 706191011919 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 706191011920 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 706191011921 30S ribosomal protein S7; Validated; Region: PRK05302 706191011922 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 706191011923 S17 interaction site [polypeptide binding]; other site 706191011924 S8 interaction site; other site 706191011925 16S rRNA interaction site [nucleotide binding]; other site 706191011926 streptomycin interaction site [chemical binding]; other site 706191011927 23S rRNA interaction site [nucleotide binding]; other site 706191011928 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 706191011929 DsrH like protein; Region: DsrH; cl17347 706191011930 sulfur relay protein TusC; Validated; Region: PRK00211 706191011931 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 706191011932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 706191011933 YheO-like PAS domain; Region: PAS_6; pfam08348 706191011934 HTH domain; Region: HTH_22; pfam13309 706191011935 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 706191011936 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 706191011937 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 706191011938 phi X174 lysis protein; Provisional; Region: PRK02793 706191011939 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 706191011940 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 706191011941 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 706191011942 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 706191011943 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 706191011944 TrkA-N domain; Region: TrkA_N; pfam02254 706191011945 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 706191011946 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 706191011947 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 706191011948 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 706191011949 ABC transporter; Region: ABC_tran_2; pfam12848 706191011950 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 706191011951 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 706191011952 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 706191011953 active site 706191011954 iron coordination sites [ion binding]; other site 706191011955 substrate binding pocket [chemical binding]; other site 706191011956 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 706191011957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191011958 dimer interface [polypeptide binding]; other site 706191011959 conserved gate region; other site 706191011960 putative PBP binding loops; other site 706191011961 ABC-ATPase subunit interface; other site 706191011962 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 706191011963 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 706191011964 Walker A/P-loop; other site 706191011965 ATP binding site [chemical binding]; other site 706191011966 Q-loop/lid; other site 706191011967 ABC transporter signature motif; other site 706191011968 Walker B; other site 706191011969 D-loop; other site 706191011970 H-loop/switch region; other site 706191011971 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 706191011972 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191011973 substrate binding pocket [chemical binding]; other site 706191011974 membrane-bound complex binding site; other site 706191011975 hinge residues; other site 706191011976 Transcriptional regulators [Transcription]; Region: PurR; COG1609 706191011977 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191011978 DNA binding site [nucleotide binding] 706191011979 domain linker motif; other site 706191011980 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 706191011981 dimerization interface [polypeptide binding]; other site 706191011982 ligand binding site [chemical binding]; other site 706191011983 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 706191011984 putative hydrolase; Provisional; Region: PRK10985 706191011985 hypothetical protein; Provisional; Region: PRK04966 706191011986 phosphoribulokinase; Provisional; Region: PRK15453 706191011987 active site 706191011988 hypothetical protein; Provisional; Region: PRK10738 706191011989 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 706191011990 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 706191011991 ligand binding site [chemical binding]; other site 706191011992 flexible hinge region; other site 706191011993 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 706191011994 putative switch regulator; other site 706191011995 non-specific DNA interactions [nucleotide binding]; other site 706191011996 DNA binding site [nucleotide binding] 706191011997 sequence specific DNA binding site [nucleotide binding]; other site 706191011998 putative cAMP binding site [chemical binding]; other site 706191011999 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 706191012000 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 706191012001 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 706191012002 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 706191012003 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 706191012004 inhibitor-cofactor binding pocket; inhibition site 706191012005 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191012006 catalytic residue [active] 706191012007 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 706191012008 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 706191012009 glutamine binding [chemical binding]; other site 706191012010 catalytic triad [active] 706191012011 cell filamentation protein Fic; Provisional; Region: PRK10347 706191012012 hypothetical protein; Provisional; Region: PRK10204 706191012013 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 706191012014 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 706191012015 substrate binding site [chemical binding]; other site 706191012016 putative transporter; Provisional; Region: PRK03699 706191012017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191012018 putative substrate translocation pore; other site 706191012019 cytosine deaminase; Provisional; Region: PRK09230 706191012020 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 706191012021 active site 706191012022 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 706191012023 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 706191012024 active site 706191012025 HIGH motif; other site 706191012026 dimer interface [polypeptide binding]; other site 706191012027 KMSKS motif; other site 706191012028 phosphoglycolate phosphatase; Provisional; Region: PRK13222 706191012029 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 706191012030 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191012031 motif II; other site 706191012032 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 706191012033 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 706191012034 substrate binding site [chemical binding]; other site 706191012035 hexamer interface [polypeptide binding]; other site 706191012036 metal binding site [ion binding]; metal-binding site 706191012037 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 706191012038 hypothetical protein; Reviewed; Region: PRK11901 706191012039 cell division protein DamX; Validated; Region: PRK10905 706191012040 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 706191012041 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 706191012042 active site 706191012043 dimer interface [polypeptide binding]; other site 706191012044 metal binding site [ion binding]; metal-binding site 706191012045 shikimate kinase; Reviewed; Region: aroK; PRK00131 706191012046 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 706191012047 ADP binding site [chemical binding]; other site 706191012048 magnesium binding site [ion binding]; other site 706191012049 putative shikimate binding site; other site 706191012050 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 706191012051 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 706191012052 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 706191012053 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 706191012054 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222 706191012055 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 706191012056 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 706191012057 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 706191012058 Transglycosylase; Region: Transgly; pfam00912 706191012059 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 706191012060 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 706191012061 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 706191012062 ADP-ribose binding site [chemical binding]; other site 706191012063 dimer interface [polypeptide binding]; other site 706191012064 active site 706191012065 nudix motif; other site 706191012066 metal binding site [ion binding]; metal-binding site 706191012067 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 706191012068 GMP/IMP nucleotidase; Provisional; Region: PRK14988 706191012069 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 706191012070 motif II; other site 706191012071 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 706191012072 RNA binding surface [nucleotide binding]; other site 706191012073 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 706191012074 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 706191012075 dimerization interface [polypeptide binding]; other site 706191012076 domain crossover interface; other site 706191012077 redox-dependent activation switch; other site 706191012078 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 706191012079 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 706191012080 active site 706191012081 substrate-binding site [chemical binding]; other site 706191012082 metal-binding site [ion binding] 706191012083 ATP binding site [chemical binding]; other site 706191012084 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 706191012085 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706191012086 dimerization interface [polypeptide binding]; other site 706191012087 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706191012088 dimer interface [polypeptide binding]; other site 706191012089 phosphorylation site [posttranslational modification] 706191012090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191012091 ATP binding site [chemical binding]; other site 706191012092 Mg2+ binding site [ion binding]; other site 706191012093 G-X-G motif; other site 706191012094 osmolarity response regulator; Provisional; Region: ompR; PRK09468 706191012095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191012096 active site 706191012097 phosphorylation site [posttranslational modification] 706191012098 intermolecular recognition site; other site 706191012099 dimerization interface [polypeptide binding]; other site 706191012100 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706191012101 DNA binding site [nucleotide binding] 706191012102 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 706191012103 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 706191012104 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 706191012105 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 706191012106 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 706191012107 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 706191012108 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 706191012109 RNA binding site [nucleotide binding]; other site 706191012110 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 706191012111 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 706191012112 active site 706191012113 homodimer interface [polypeptide binding]; other site 706191012114 catalytic site [active] 706191012115 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 706191012116 carboxylesterase BioH; Provisional; Region: PRK10349 706191012117 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 706191012118 DNA utilization protein GntX; Provisional; Region: PRK11595 706191012119 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 706191012120 active site 706191012121 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 706191012122 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 706191012123 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 706191012124 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 706191012125 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 706191012126 maltodextrin phosphorylase; Provisional; Region: PRK14985 706191012127 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 706191012128 homodimer interface [polypeptide binding]; other site 706191012129 active site pocket [active] 706191012130 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 706191012131 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 706191012132 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 706191012133 intramembrane serine protease GlpG; Provisional; Region: PRK10907 706191012134 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 706191012135 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 706191012136 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 706191012137 active site residue [active] 706191012138 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 706191012139 glycogen phosphorylase; Provisional; Region: PRK14986 706191012140 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 706191012141 homodimer interface [polypeptide binding]; other site 706191012142 active site pocket [active] 706191012143 glycogen synthase; Provisional; Region: glgA; PRK00654 706191012144 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 706191012145 ADP-binding pocket [chemical binding]; other site 706191012146 homodimer interface [polypeptide binding]; other site 706191012147 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 706191012148 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 706191012149 ligand binding site; other site 706191012150 oligomer interface; other site 706191012151 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 706191012152 dimer interface [polypeptide binding]; other site 706191012153 N-terminal domain interface [polypeptide binding]; other site 706191012154 sulfate 1 binding site; other site 706191012155 glycogen debranching enzyme; Provisional; Region: PRK03705 706191012156 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 706191012157 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 706191012158 active site 706191012159 catalytic site [active] 706191012160 glycogen branching enzyme; Provisional; Region: PRK05402 706191012161 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 706191012162 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 706191012163 active site 706191012164 catalytic site [active] 706191012165 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 706191012166 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 706191012167 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 706191012168 putative antibiotic transporter; Provisional; Region: PRK10739 706191012169 low affinity gluconate transporter; Provisional; Region: PRK10472 706191012170 gluconate transporter; Region: gntP; TIGR00791 706191012171 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 706191012172 ATP-binding site [chemical binding]; other site 706191012173 Gluconate-6-phosphate binding site [chemical binding]; other site 706191012174 Shikimate kinase; Region: SKI; pfam01202 706191012175 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 706191012176 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191012177 DNA binding site [nucleotide binding] 706191012178 domain linker motif; other site 706191012179 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 706191012180 putative ligand binding site [chemical binding]; other site 706191012181 putative dimerization interface [polypeptide binding]; other site 706191012182 Pirin-related protein [General function prediction only]; Region: COG1741 706191012183 Pirin; Region: Pirin; pfam02678 706191012184 putative acetyltransferase YhhY; Provisional; Region: PRK10140 706191012185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191012186 Coenzyme A binding pocket [chemical binding]; other site 706191012187 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 706191012188 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 706191012189 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 706191012190 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 706191012191 putative active site [active] 706191012192 catalytic site [active] 706191012193 putative metal binding site [ion binding]; other site 706191012194 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 706191012195 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 706191012196 Walker A/P-loop; other site 706191012197 ATP binding site [chemical binding]; other site 706191012198 Q-loop/lid; other site 706191012199 ABC transporter signature motif; other site 706191012200 Walker B; other site 706191012201 D-loop; other site 706191012202 H-loop/switch region; other site 706191012203 TOBE domain; Region: TOBE_2; pfam08402 706191012204 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 706191012205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191012206 dimer interface [polypeptide binding]; other site 706191012207 conserved gate region; other site 706191012208 putative PBP binding loops; other site 706191012209 ABC-ATPase subunit interface; other site 706191012210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191012211 dimer interface [polypeptide binding]; other site 706191012212 conserved gate region; other site 706191012213 putative PBP binding loops; other site 706191012214 ABC-ATPase subunit interface; other site 706191012215 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 706191012216 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 706191012217 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 706191012218 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 706191012219 Walker A/P-loop; other site 706191012220 ATP binding site [chemical binding]; other site 706191012221 Q-loop/lid; other site 706191012222 ABC transporter signature motif; other site 706191012223 Walker B; other site 706191012224 D-loop; other site 706191012225 H-loop/switch region; other site 706191012226 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 706191012227 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 706191012228 Walker A/P-loop; other site 706191012229 ATP binding site [chemical binding]; other site 706191012230 Q-loop/lid; other site 706191012231 ABC transporter signature motif; other site 706191012232 Walker B; other site 706191012233 D-loop; other site 706191012234 H-loop/switch region; other site 706191012235 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 706191012236 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 706191012237 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 706191012238 TM-ABC transporter signature motif; other site 706191012239 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 706191012240 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 706191012241 TM-ABC transporter signature motif; other site 706191012242 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 706191012243 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 706191012244 dimerization interface [polypeptide binding]; other site 706191012245 ligand binding site [chemical binding]; other site 706191012246 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 706191012247 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 706191012248 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 706191012249 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 706191012250 DNA binding residues [nucleotide binding] 706191012251 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 706191012252 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 706191012253 cell division protein FtsE; Provisional; Region: PRK10908 706191012254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191012255 Walker A/P-loop; other site 706191012256 ATP binding site [chemical binding]; other site 706191012257 Q-loop/lid; other site 706191012258 ABC transporter signature motif; other site 706191012259 Walker B; other site 706191012260 D-loop; other site 706191012261 H-loop/switch region; other site 706191012262 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 706191012263 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 706191012264 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 706191012265 P loop; other site 706191012266 GTP binding site [chemical binding]; other site 706191012267 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 706191012268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191012269 S-adenosylmethionine binding site [chemical binding]; other site 706191012270 hypothetical protein; Provisional; Region: PRK10910 706191012271 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 706191012272 Predicted membrane protein [Function unknown]; Region: COG3714 706191012273 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 706191012274 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 706191012275 metal-binding site [ion binding] 706191012276 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 706191012277 Soluble P-type ATPase [General function prediction only]; Region: COG4087 706191012278 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 706191012279 CPxP motif; other site 706191012280 hypothetical protein; Provisional; Region: PRK11212 706191012281 hypothetical protein; Provisional; Region: PRK11615 706191012282 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 706191012283 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 706191012284 substrate binding site [chemical binding]; other site 706191012285 ATP binding site [chemical binding]; other site 706191012286 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 706191012287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 706191012288 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 706191012289 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 706191012290 PYR/PP interface [polypeptide binding]; other site 706191012291 dimer interface [polypeptide binding]; other site 706191012292 TPP binding site [chemical binding]; other site 706191012293 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 706191012294 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 706191012295 TPP-binding site; other site 706191012296 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 706191012297 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 706191012298 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 706191012299 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 706191012300 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 706191012301 Metal-binding active site; metal-binding site 706191012302 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 706191012303 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 706191012304 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 706191012305 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 706191012306 putative active site [active] 706191012307 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 706191012308 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 706191012309 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 706191012310 tetrameric interface [polypeptide binding]; other site 706191012311 NAD binding site [chemical binding]; other site 706191012312 catalytic residues [active] 706191012313 xanthine permease; Region: pbuX; TIGR03173 706191012314 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 706191012315 Domain of unknown function DUF20; Region: UPF0118; pfam01594 706191012316 Transcriptional regulators [Transcription]; Region: FadR; COG2186 706191012317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191012318 DNA-binding site [nucleotide binding]; DNA binding site 706191012319 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 706191012320 mannonate dehydratase; Region: uxuA; TIGR00695 706191012321 mannonate dehydratase; Provisional; Region: PRK03906 706191012322 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 706191012323 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 706191012324 proline/glycine betaine transporter; Provisional; Region: PRK10642 706191012325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191012326 putative substrate translocation pore; other site 706191012327 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 706191012328 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 706191012329 dimer interface [polypeptide binding]; other site 706191012330 active site 706191012331 Schiff base residues; other site 706191012332 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 706191012333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191012334 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191012335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 706191012336 short chain dehydrogenase; Provisional; Region: PRK08177 706191012337 C factor cell-cell signaling protein; Provisional; Region: PRK09009 706191012338 NAD(P) binding site [chemical binding]; other site 706191012339 active site 706191012340 Archaeal Glu-tRNAGln amidotransferase subunit E (contains GAD domain) [Translation, ribosomal structure and biogenesis]; Region: GatE; COG2511 706191012341 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 706191012342 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 706191012343 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 706191012344 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 706191012345 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 706191012346 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 706191012347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191012348 dimer interface [polypeptide binding]; other site 706191012349 conserved gate region; other site 706191012350 putative PBP binding loops; other site 706191012351 ABC-ATPase subunit interface; other site 706191012352 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 706191012353 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 706191012354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191012355 dimer interface [polypeptide binding]; other site 706191012356 conserved gate region; other site 706191012357 putative PBP binding loops; other site 706191012358 ABC-ATPase subunit interface; other site 706191012359 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 706191012360 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706191012361 Walker A/P-loop; other site 706191012362 ATP binding site [chemical binding]; other site 706191012363 Q-loop/lid; other site 706191012364 ABC transporter signature motif; other site 706191012365 Walker B; other site 706191012366 D-loop; other site 706191012367 H-loop/switch region; other site 706191012368 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 706191012369 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 706191012370 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706191012371 Walker A/P-loop; other site 706191012372 ATP binding site [chemical binding]; other site 706191012373 Q-loop/lid; other site 706191012374 ABC transporter signature motif; other site 706191012375 Walker B; other site 706191012376 D-loop; other site 706191012377 H-loop/switch region; other site 706191012378 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 706191012379 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 706191012380 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 706191012381 hydroxyglutarate oxidase; Provisional; Region: PRK11728 706191012382 Predicted flavoproteins [General function prediction only]; Region: COG2081 706191012383 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706191012384 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 706191012385 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 706191012386 universal stress protein UspB; Provisional; Region: PRK04960 706191012387 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 706191012388 Ligand Binding Site [chemical binding]; other site 706191012389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191012390 S-adenosylmethionine binding site [chemical binding]; other site 706191012391 oligopeptidase A; Provisional; Region: PRK10911 706191012392 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 706191012393 active site 706191012394 Zn binding site [ion binding]; other site 706191012395 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 706191012396 CAAX protease self-immunity; Region: Abi; cl00558 706191012397 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 706191012398 glutathione reductase; Validated; Region: PRK06116 706191012399 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 706191012400 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706191012401 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 706191012402 Transcriptional regulators [Transcription]; Region: MarR; COG1846 706191012403 MarR family; Region: MarR_2; pfam12802 706191012404 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 706191012405 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 706191012406 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 706191012407 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 706191012408 active site 706191012409 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 706191012410 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191012411 Walker A/P-loop; other site 706191012412 ATP binding site [chemical binding]; other site 706191012413 Q-loop/lid; other site 706191012414 ABC transporter signature motif; other site 706191012415 Walker B; other site 706191012416 D-loop; other site 706191012417 H-loop/switch region; other site 706191012418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191012419 conserved gate region; other site 706191012420 ABC-ATPase subunit interface; other site 706191012421 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 706191012422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191012423 dimer interface [polypeptide binding]; other site 706191012424 conserved gate region; other site 706191012425 putative PBP binding loops; other site 706191012426 ABC-ATPase subunit interface; other site 706191012427 hypothetical protein; Provisional; Region: PRK11622 706191012428 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 706191012429 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 706191012430 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 706191012431 putative active site [active] 706191012432 catalytic site [active] 706191012433 putative metal binding site [ion binding]; other site 706191012434 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 706191012435 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 706191012436 trimer interface [polypeptide binding]; other site 706191012437 eyelet of channel; other site 706191012438 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 706191012439 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 706191012440 nucleophilic elbow; other site 706191012441 catalytic triad; other site 706191012442 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 706191012443 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 706191012444 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 706191012445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191012446 putative substrate translocation pore; other site 706191012447 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191012448 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191012449 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 706191012450 putative effector binding pocket; other site 706191012451 dimerization interface [polypeptide binding]; other site 706191012452 hypothetical protein; Provisional; Region: PRK05208 706191012453 sensor protein KdpD; Provisional; Region: PRK10490 706191012454 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 706191012455 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 706191012456 Ligand Binding Site [chemical binding]; other site 706191012457 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 706191012458 GAF domain; Region: GAF_3; pfam13492 706191012459 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706191012460 dimer interface [polypeptide binding]; other site 706191012461 phosphorylation site [posttranslational modification] 706191012462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191012463 ATP binding site [chemical binding]; other site 706191012464 Mg2+ binding site [ion binding]; other site 706191012465 G-X-G motif; other site 706191012466 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 706191012467 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 706191012468 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 706191012469 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 706191012470 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 706191012471 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 706191012472 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706191012473 Zn2+ binding site [ion binding]; other site 706191012474 Mg2+ binding site [ion binding]; other site 706191012475 putative acetyltransferase YhhY; Provisional; Region: PRK10140 706191012476 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 706191012477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 706191012478 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 706191012479 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 706191012480 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191012481 Walker A/P-loop; other site 706191012482 ATP binding site [chemical binding]; other site 706191012483 Q-loop/lid; other site 706191012484 ABC transporter signature motif; other site 706191012485 Walker B; other site 706191012486 D-loop; other site 706191012487 H-loop/switch region; other site 706191012488 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 706191012489 Protein of unknown function, DUF482; Region: DUF482; pfam04339 706191012490 putative hydrolase; Provisional; Region: PRK11460 706191012491 Predicted esterase [General function prediction only]; Region: COG0400 706191012492 chromosome condensation membrane protein; Provisional; Region: PRK14196 706191012493 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 706191012494 active site 706191012495 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 706191012496 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 706191012497 putative NAD(P) binding site [chemical binding]; other site 706191012498 catalytic Zn binding site [ion binding]; other site 706191012499 structural Zn binding site [ion binding]; other site 706191012500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191012501 DNA-binding site [nucleotide binding]; DNA binding site 706191012502 Transcriptional regulators [Transcription]; Region: FadR; COG2186 706191012503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 706191012504 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 706191012505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191012506 D-galactonate transporter; Region: 2A0114; TIGR00893 706191012507 putative substrate translocation pore; other site 706191012508 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 706191012509 TAP-like protein; Region: Abhydrolase_4; pfam08386 706191012510 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 706191012511 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 706191012512 hypothetical protein; Provisional; Region: PRK11469 706191012513 Domain of unknown function DUF; Region: DUF204; pfam02659 706191012514 Domain of unknown function DUF; Region: DUF204; pfam02659 706191012515 malate:quinone oxidoreductase; Validated; Region: PRK05257 706191012516 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 706191012517 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 706191012518 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 706191012519 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 706191012520 DNA-binding site [nucleotide binding]; DNA binding site 706191012521 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 706191012522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191012523 homodimer interface [polypeptide binding]; other site 706191012524 catalytic residue [active] 706191012525 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 706191012526 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 706191012527 putative C-terminal domain interface [polypeptide binding]; other site 706191012528 putative GSH binding site (G-site) [chemical binding]; other site 706191012529 putative dimer interface [polypeptide binding]; other site 706191012530 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 706191012531 putative N-terminal domain interface [polypeptide binding]; other site 706191012532 putative dimer interface [polypeptide binding]; other site 706191012533 putative substrate binding pocket (H-site) [chemical binding]; other site 706191012534 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 706191012535 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 706191012536 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 706191012537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 706191012538 NAD(P) binding site [chemical binding]; other site 706191012539 active site 706191012540 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191012541 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191012542 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 706191012543 putative effector binding pocket; other site 706191012544 putative dimerization interface [polypeptide binding]; other site 706191012545 inner membrane protein YhjD; Region: TIGR00766 706191012546 metabolite-proton symporter; Region: 2A0106; TIGR00883 706191012547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191012548 putative substrate translocation pore; other site 706191012549 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191012550 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191012551 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 706191012552 putative effector binding pocket; other site 706191012553 dimerization interface [polypeptide binding]; other site 706191012554 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 706191012555 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191012556 substrate binding pocket [chemical binding]; other site 706191012557 membrane-bound complex binding site; other site 706191012558 hinge residues; other site 706191012559 Biofilm formation and stress response factor; Region: BsmA; pfam10014 706191012560 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 706191012561 classical (c) SDRs; Region: SDR_c; cd05233 706191012562 NAD(P) binding site [chemical binding]; other site 706191012563 active site 706191012564 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 706191012565 H+ Antiporter protein; Region: 2A0121; TIGR00900 706191012566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191012567 putative substrate translocation pore; other site 706191012568 ketol-acid reductoisomerase; Validated; Region: PRK05225 706191012569 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 706191012570 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 706191012571 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 706191012572 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191012573 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 706191012574 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 706191012575 putative dimerization interface [polypeptide binding]; other site 706191012576 threonine dehydratase; Reviewed; Region: PRK09224 706191012577 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 706191012578 tetramer interface [polypeptide binding]; other site 706191012579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191012580 catalytic residue [active] 706191012581 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 706191012582 putative Ile/Val binding site [chemical binding]; other site 706191012583 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 706191012584 putative Ile/Val binding site [chemical binding]; other site 706191012585 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 706191012586 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 706191012587 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 706191012588 homodimer interface [polypeptide binding]; other site 706191012589 substrate-cofactor binding pocket; other site 706191012590 catalytic residue [active] 706191012591 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 706191012592 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 706191012593 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 706191012594 PYR/PP interface [polypeptide binding]; other site 706191012595 dimer interface [polypeptide binding]; other site 706191012596 TPP binding site [chemical binding]; other site 706191012597 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 706191012598 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 706191012599 TPP-binding site [chemical binding]; other site 706191012600 dimer interface [polypeptide binding]; other site 706191012601 putative ATP-dependent protease; Provisional; Region: PRK09862 706191012602 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 706191012603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191012604 Walker A motif; other site 706191012605 ATP binding site [chemical binding]; other site 706191012606 Walker B motif; other site 706191012607 arginine finger; other site 706191012608 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 706191012609 hypothetical protein; Provisional; Region: PRK11027 706191012610 transcriptional regulator HdfR; Provisional; Region: PRK03601 706191012611 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191012612 LysR substrate binding domain; Region: LysR_substrate; pfam03466 706191012613 dimerization interface [polypeptide binding]; other site 706191012614 glutamate racemase; Provisional; Region: PRK00865 706191012615 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 706191012616 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 706191012617 N-terminal plug; other site 706191012618 ligand-binding site [chemical binding]; other site 706191012619 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 706191012620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 706191012621 S-adenosylmethionine binding site [chemical binding]; other site 706191012622 hypothetical protein; Provisional; Region: PRK11056 706191012623 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 706191012624 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706191012625 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 706191012626 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 706191012627 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 706191012628 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 706191012629 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191012630 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 706191012631 dimerization interface [polypeptide binding]; other site 706191012632 argininosuccinate lyase; Provisional; Region: PRK04833 706191012633 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 706191012634 active sites [active] 706191012635 tetramer interface [polypeptide binding]; other site 706191012636 argininosuccinate synthase; Provisional; Region: PRK13820 706191012637 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 706191012638 ANP binding site [chemical binding]; other site 706191012639 Substrate Binding Site II [chemical binding]; other site 706191012640 Substrate Binding Site I [chemical binding]; other site 706191012641 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 706191012642 nucleotide binding site [chemical binding]; other site 706191012643 N-acetyl-L-glutamate binding site [chemical binding]; other site 706191012644 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 706191012645 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 706191012646 acetylornithine deacetylase; Provisional; Region: PRK05111 706191012647 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 706191012648 metal binding site [ion binding]; metal-binding site 706191012649 putative dimer interface [polypeptide binding]; other site 706191012650 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 706191012651 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 706191012652 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 706191012653 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706191012654 dimerization interface [polypeptide binding]; other site 706191012655 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706191012656 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191012657 dimer interface [polypeptide binding]; other site 706191012658 putative CheW interface [polypeptide binding]; other site 706191012659 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 706191012660 FAD binding site [chemical binding]; other site 706191012661 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 706191012662 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 706191012663 putative catalytic residues [active] 706191012664 putative nucleotide binding site [chemical binding]; other site 706191012665 putative aspartate binding site [chemical binding]; other site 706191012666 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 706191012667 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 706191012668 cystathionine gamma-synthase; Provisional; Region: PRK08045 706191012669 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 706191012670 homodimer interface [polypeptide binding]; other site 706191012671 substrate-cofactor binding pocket; other site 706191012672 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191012673 catalytic residue [active] 706191012674 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 706191012675 dimerization interface [polypeptide binding]; other site 706191012676 DNA binding site [nucleotide binding] 706191012677 corepressor binding sites; other site 706191012678 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 706191012679 primosome assembly protein PriA; Validated; Region: PRK05580 706191012680 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 706191012681 ATP binding site [chemical binding]; other site 706191012682 putative Mg++ binding site [ion binding]; other site 706191012683 helicase superfamily c-terminal domain; Region: HELICc; smart00490 706191012684 ATP-binding site [chemical binding]; other site 706191012685 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191012686 DNA binding site [nucleotide binding] 706191012687 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 706191012688 domain linker motif; other site 706191012689 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 706191012690 dimerization interface [polypeptide binding]; other site 706191012691 ligand binding site [chemical binding]; other site 706191012692 cell division protein FtsN; Provisional; Region: PRK12757 706191012693 Sporulation related domain; Region: SPOR; cl10051 706191012694 Sporulation related domain; Region: SPOR; cl10051 706191012695 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 706191012696 active site 706191012697 HslU subunit interaction site [polypeptide binding]; other site 706191012698 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 706191012699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191012700 Walker A motif; other site 706191012701 ATP binding site [chemical binding]; other site 706191012702 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 706191012703 Walker B motif; other site 706191012704 arginine finger; other site 706191012705 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 706191012706 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 706191012707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 706191012708 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 706191012709 amphipathic channel; other site 706191012710 Asn-Pro-Ala signature motifs; other site 706191012711 glycerol kinase; Provisional; Region: glpK; PRK00047 706191012712 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 706191012713 N- and C-terminal domain interface [polypeptide binding]; other site 706191012714 active site 706191012715 MgATP binding site [chemical binding]; other site 706191012716 catalytic site [active] 706191012717 metal binding site [ion binding]; metal-binding site 706191012718 glycerol binding site [chemical binding]; other site 706191012719 homotetramer interface [polypeptide binding]; other site 706191012720 homodimer interface [polypeptide binding]; other site 706191012721 FBP binding site [chemical binding]; other site 706191012722 protein IIAGlc interface [polypeptide binding]; other site 706191012723 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 706191012724 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 706191012725 putative active site [active] 706191012726 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 706191012727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191012728 putative substrate translocation pore; other site 706191012729 ferredoxin-NADP reductase; Provisional; Region: PRK10926 706191012730 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 706191012731 FAD binding pocket [chemical binding]; other site 706191012732 FAD binding motif [chemical binding]; other site 706191012733 phosphate binding motif [ion binding]; other site 706191012734 beta-alpha-beta structure motif; other site 706191012735 NAD binding pocket [chemical binding]; other site 706191012736 Predicted membrane protein [Function unknown]; Region: COG3152 706191012737 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 706191012738 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 706191012739 triosephosphate isomerase; Provisional; Region: PRK14567 706191012740 substrate binding site [chemical binding]; other site 706191012741 dimer interface [polypeptide binding]; other site 706191012742 catalytic triad [active] 706191012743 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 706191012744 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 706191012745 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191012746 substrate binding pocket [chemical binding]; other site 706191012747 membrane-bound complex binding site; other site 706191012748 hinge residues; other site 706191012749 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 706191012750 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 706191012751 active site 706191012752 ADP/pyrophosphate binding site [chemical binding]; other site 706191012753 dimerization interface [polypeptide binding]; other site 706191012754 allosteric effector site; other site 706191012755 fructose-1,6-bisphosphate binding site; other site 706191012756 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 706191012757 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 706191012758 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 706191012759 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 706191012760 dimer interface [polypeptide binding]; other site 706191012761 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 706191012762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191012763 active site 706191012764 intermolecular recognition site; other site 706191012765 dimerization interface [polypeptide binding]; other site 706191012766 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706191012767 DNA binding site [nucleotide binding] 706191012768 two-component sensor protein; Provisional; Region: cpxA; PRK09470 706191012769 HAMP domain; Region: HAMP; pfam00672 706191012770 dimerization interface [polypeptide binding]; other site 706191012771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 706191012772 dimer interface [polypeptide binding]; other site 706191012773 phosphorylation site [posttranslational modification] 706191012774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191012775 ATP binding site [chemical binding]; other site 706191012776 Mg2+ binding site [ion binding]; other site 706191012777 G-X-G motif; other site 706191012778 putative rRNA methylase; Provisional; Region: PRK10358 706191012779 serine acetyltransferase; Provisional; Region: cysE; PRK11132 706191012780 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 706191012781 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 706191012782 trimer interface [polypeptide binding]; other site 706191012783 active site 706191012784 substrate binding site [chemical binding]; other site 706191012785 CoA binding site [chemical binding]; other site 706191012786 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 706191012787 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 706191012788 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 706191012789 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 706191012790 SecA binding site; other site 706191012791 Preprotein binding site; other site 706191012792 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 706191012793 GSH binding site [chemical binding]; other site 706191012794 catalytic residues [active] 706191012795 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 706191012796 active site residue [active] 706191012797 AmiB activator; Provisional; Region: PRK11637 706191012798 Peptidase family M23; Region: Peptidase_M23; pfam01551 706191012799 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 706191012800 NodB motif; other site 706191012801 putative active site [active] 706191012802 putative catalytic site [active] 706191012803 Zn binding site [ion binding]; other site 706191012804 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 706191012805 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 706191012806 NAD(P) binding site [chemical binding]; other site 706191012807 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 706191012808 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 706191012809 substrate-cofactor binding pocket; other site 706191012810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191012811 catalytic residue [active] 706191012812 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 706191012813 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 706191012814 NADP binding site [chemical binding]; other site 706191012815 homopentamer interface [polypeptide binding]; other site 706191012816 substrate binding site [chemical binding]; other site 706191012817 active site 706191012818 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 706191012819 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 706191012820 putative active site [active] 706191012821 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 706191012822 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 706191012823 putative active site [active] 706191012824 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706191012825 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 706191012826 putative glycosyl transferase; Provisional; Region: PRK10073 706191012827 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 706191012828 active site 706191012829 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 706191012830 putative active site [active] 706191012831 putative catalytic site [active] 706191012832 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706191012833 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 706191012834 putative ADP-binding pocket [chemical binding]; other site 706191012835 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 706191012836 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 706191012837 putative active site [active] 706191012838 putative glycosyl transferase; Provisional; Region: PRK10073 706191012839 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 706191012840 active site 706191012841 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 706191012842 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 706191012843 putative active site [active] 706191012844 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 706191012845 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 706191012846 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 706191012847 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 706191012848 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 706191012849 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 706191012850 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 706191012851 putative metal binding site; other site 706191012852 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 706191012853 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 706191012854 active site 706191012855 (T/H)XGH motif; other site 706191012856 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 706191012857 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 706191012858 DNA binding site [nucleotide binding] 706191012859 catalytic residue [active] 706191012860 H2TH interface [polypeptide binding]; other site 706191012861 putative catalytic residues [active] 706191012862 turnover-facilitating residue; other site 706191012863 intercalation triad [nucleotide binding]; other site 706191012864 8OG recognition residue [nucleotide binding]; other site 706191012865 putative reading head residues; other site 706191012866 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 706191012867 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 706191012868 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 706191012869 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 706191012870 hypothetical protein; Reviewed; Region: PRK00024 706191012871 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 706191012872 MPN+ (JAMM) motif; other site 706191012873 Zinc-binding site [ion binding]; other site 706191012874 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 706191012875 Flavoprotein; Region: Flavoprotein; pfam02441 706191012876 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 706191012877 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 706191012878 trimer interface [polypeptide binding]; other site 706191012879 active site 706191012880 division inhibitor protein; Provisional; Region: slmA; PRK09480 706191012881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706191012882 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 706191012883 active site 706191012884 ribonuclease PH; Reviewed; Region: rph; PRK00173 706191012885 Ribonuclease PH; Region: RNase_PH_bact; cd11362 706191012886 hexamer interface [polypeptide binding]; other site 706191012887 active site 706191012888 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 706191012889 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 706191012890 Nucleoside recognition; Region: Gate; pfam07670 706191012891 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 706191012892 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 706191012893 hypothetical protein; Provisional; Region: PRK11820 706191012894 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 706191012895 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 706191012896 integrase; Provisional; Region: PRK09692 706191012897 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 706191012898 active site 706191012899 Int/Topo IB signature motif; other site 706191012900 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 706191012901 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 706191012902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 706191012903 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 706191012904 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 706191012905 active site 706191012906 metal binding site [ion binding]; metal-binding site 706191012907 interdomain interaction site; other site 706191012908 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 706191012909 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 706191012910 EVE domain; Region: EVE; cl00728 706191012911 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 706191012912 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 706191012913 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 706191012914 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 706191012915 putative acyl-acceptor binding pocket; other site 706191012916 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 706191012917 Predicted membrane protein [Function unknown]; Region: COG2860 706191012918 UPF0126 domain; Region: UPF0126; pfam03458 706191012919 UPF0126 domain; Region: UPF0126; pfam03458 706191012920 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 706191012921 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 706191012922 nucleotide binding pocket [chemical binding]; other site 706191012923 K-X-D-G motif; other site 706191012924 catalytic site [active] 706191012925 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 706191012926 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 706191012927 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 706191012928 catalytic site [active] 706191012929 G-X2-G-X-G-K; other site 706191012930 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 706191012931 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 706191012932 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 706191012933 Zn2+ binding site [ion binding]; other site 706191012934 Mg2+ binding site [ion binding]; other site 706191012935 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 706191012936 synthetase active site [active] 706191012937 NTP binding site [chemical binding]; other site 706191012938 metal binding site [ion binding]; metal-binding site 706191012939 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 706191012940 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 706191012941 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 706191012942 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 706191012943 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 706191012944 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 706191012945 Y-family of DNA polymerases; Region: PolY; cl12025 706191012946 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 706191012947 generic binding surface II; other site 706191012948 ssDNA binding site; other site 706191012949 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 706191012950 ATP binding site [chemical binding]; other site 706191012951 putative Mg++ binding site [ion binding]; other site 706191012952 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 706191012953 nucleotide binding region [chemical binding]; other site 706191012954 ATP-binding site [chemical binding]; other site 706191012955 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 706191012956 AsmA family; Region: AsmA; pfam05170 706191012957 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 706191012958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191012959 Coenzyme A binding pocket [chemical binding]; other site 706191012960 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 706191012961 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 706191012962 putative active site [active] 706191012963 dimerization interface [polypeptide binding]; other site 706191012964 putative tRNAtyr binding site [nucleotide binding]; other site 706191012965 hypothetical protein; Reviewed; Region: PRK01637 706191012966 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 706191012967 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191012968 motif II; other site 706191012969 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 706191012970 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 706191012971 G2 box; other site 706191012972 Switch I region; other site 706191012973 G3 box; other site 706191012974 Switch II region; other site 706191012975 GTP/Mg2+ binding site [chemical binding]; other site 706191012976 G4 box; other site 706191012977 G5 box; other site 706191012978 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 706191012979 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 706191012980 glutamine synthetase; Provisional; Region: glnA; PRK09469 706191012981 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 706191012982 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 706191012983 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 706191012984 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706191012985 putative active site [active] 706191012986 heme pocket [chemical binding]; other site 706191012987 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706191012988 dimer interface [polypeptide binding]; other site 706191012989 phosphorylation site [posttranslational modification] 706191012990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191012991 ATP binding site [chemical binding]; other site 706191012992 Mg2+ binding site [ion binding]; other site 706191012993 G-X-G motif; other site 706191012994 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 706191012995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191012996 active site 706191012997 phosphorylation site [posttranslational modification] 706191012998 intermolecular recognition site; other site 706191012999 dimerization interface [polypeptide binding]; other site 706191013000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191013001 Walker A motif; other site 706191013002 ATP binding site [chemical binding]; other site 706191013003 Walker B motif; other site 706191013004 arginine finger; other site 706191013005 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 706191013006 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 706191013007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 706191013008 FeS/SAM binding site; other site 706191013009 HemN C-terminal domain; Region: HemN_C; pfam06969 706191013010 Der GTPase activator; Provisional; Region: PRK05244 706191013011 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 706191013012 G1 box; other site 706191013013 GTP/Mg2+ binding site [chemical binding]; other site 706191013014 Switch I region; other site 706191013015 G2 box; other site 706191013016 G3 box; other site 706191013017 Switch II region; other site 706191013018 G4 box; other site 706191013019 G5 box; other site 706191013020 DNA polymerase I; Provisional; Region: PRK05755 706191013021 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 706191013022 active site 706191013023 metal binding site 1 [ion binding]; metal-binding site 706191013024 putative 5' ssDNA interaction site; other site 706191013025 metal binding site 3; metal-binding site 706191013026 metal binding site 2 [ion binding]; metal-binding site 706191013027 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 706191013028 putative DNA binding site [nucleotide binding]; other site 706191013029 putative metal binding site [ion binding]; other site 706191013030 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 706191013031 active site 706191013032 catalytic site [active] 706191013033 substrate binding site [chemical binding]; other site 706191013034 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 706191013035 active site 706191013036 DNA binding site [nucleotide binding] 706191013037 catalytic site [active] 706191013038 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 706191013039 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 706191013040 catalytic residues [active] 706191013041 hinge region; other site 706191013042 alpha helical domain; other site 706191013043 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 706191013044 serine/threonine protein kinase; Provisional; Region: PRK11768 706191013045 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 706191013046 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 706191013047 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 706191013048 GTP binding site; other site 706191013049 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 706191013050 Walker A motif; other site 706191013051 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 706191013052 active site 706191013053 dimerization interface [polypeptide binding]; other site 706191013054 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 706191013055 YebG protein; Region: YebG; pfam07130 706191013056 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 706191013057 Cache domain; Region: Cache_1; pfam02743 706191013058 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706191013059 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191013060 dimer interface [polypeptide binding]; other site 706191013061 putative CheW interface [polypeptide binding]; other site 706191013062 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 706191013063 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 706191013064 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 706191013065 NAD(P) binding site [chemical binding]; other site 706191013066 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191013067 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191013068 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 706191013069 putative dimerization interface [polypeptide binding]; other site 706191013070 putative substrate binding pocket [chemical binding]; other site 706191013071 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 706191013072 acetolactate synthase; Reviewed; Region: PRK08617 706191013073 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 706191013074 PYR/PP interface [polypeptide binding]; other site 706191013075 dimer interface [polypeptide binding]; other site 706191013076 TPP binding site [chemical binding]; other site 706191013077 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 706191013078 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 706191013079 TPP-binding site [chemical binding]; other site 706191013080 acetoin reductase; Validated; Region: PRK08643 706191013081 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 706191013082 NAD binding site [chemical binding]; other site 706191013083 homotetramer interface [polypeptide binding]; other site 706191013084 homodimer interface [polypeptide binding]; other site 706191013085 active site 706191013086 substrate binding site [chemical binding]; other site 706191013087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 706191013088 SnoaL-like domain; Region: SnoaL_2; pfam12680 706191013089 riboflavin synthase subunit beta; Provisional; Region: PRK12419 706191013090 active site 706191013091 homopentamer interface [polypeptide binding]; other site 706191013092 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 706191013093 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 706191013094 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 706191013095 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 706191013096 Cupin domain; Region: Cupin_2; cl17218 706191013097 short chain dehydrogenase; Provisional; Region: PRK07577 706191013098 classical (c) SDRs; Region: SDR_c; cd05233 706191013099 NAD(P) binding site [chemical binding]; other site 706191013100 active site 706191013101 Domain of unknown function (DUF386); Region: DUF386; cl01047 706191013102 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 706191013103 BNR repeat-like domain; Region: BNR_2; pfam13088 706191013104 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 706191013105 Na binding site [ion binding]; other site 706191013106 dihydrodipicolinate synthase; Region: dapA; TIGR00674 706191013107 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 706191013108 inhibitor site; inhibition site 706191013109 active site 706191013110 dimer interface [polypeptide binding]; other site 706191013111 catalytic residue [active] 706191013112 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 706191013113 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 706191013114 active site 706191013115 NAD binding site [chemical binding]; other site 706191013116 metal binding site [ion binding]; metal-binding site 706191013117 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 706191013118 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 706191013119 tyrosine phenol-lyase; Provisional; Region: PRK13237 706191013120 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 706191013121 substrate binding site [chemical binding]; other site 706191013122 tetramer interface [polypeptide binding]; other site 706191013123 catalytic residue [active] 706191013124 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 706191013125 aromatic amino acid transport protein; Region: araaP; TIGR00837 706191013126 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 706191013127 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 706191013128 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 706191013129 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 706191013130 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 706191013131 substrate binding pocket [chemical binding]; other site 706191013132 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 706191013133 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 706191013134 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 706191013135 EamA-like transporter family; Region: EamA; pfam00892 706191013136 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 706191013137 EamA-like transporter family; Region: EamA; pfam00892 706191013138 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 706191013139 putative active site pocket [active] 706191013140 dimerization interface [polypeptide binding]; other site 706191013141 putative catalytic residue [active] 706191013142 HAMP domain; Region: HAMP; pfam00672 706191013143 dimerization interface [polypeptide binding]; other site 706191013144 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706191013145 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191013146 dimer interface [polypeptide binding]; other site 706191013147 putative CheW interface [polypeptide binding]; other site 706191013148 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 706191013149 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 706191013150 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 706191013151 HlyD family secretion protein; Region: HlyD_3; pfam13437 706191013152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 706191013153 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 706191013154 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 706191013155 dimer interface [polypeptide binding]; other site 706191013156 phosphorylation site [posttranslational modification] 706191013157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191013158 ATP binding site [chemical binding]; other site 706191013159 Mg2+ binding site [ion binding]; other site 706191013160 G-X-G motif; other site 706191013161 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 706191013162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191013163 active site 706191013164 phosphorylation site [posttranslational modification] 706191013165 intermolecular recognition site; other site 706191013166 dimerization interface [polypeptide binding]; other site 706191013167 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 706191013168 DNA binding site [nucleotide binding] 706191013169 MltA-interacting protein MipA; Region: MipA; cl01504 706191013170 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 706191013171 dimer interface [polypeptide binding]; other site 706191013172 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 706191013173 ligand binding site [chemical binding]; other site 706191013174 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 706191013175 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 706191013176 inhibitor-cofactor binding pocket; inhibition site 706191013177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191013178 catalytic residue [active] 706191013179 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 706191013180 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 706191013181 Ligand binding site; other site 706191013182 Putative Catalytic site; other site 706191013183 DXD motif; other site 706191013184 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 706191013185 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 706191013186 active site 706191013187 substrate binding site [chemical binding]; other site 706191013188 cosubstrate binding site; other site 706191013189 catalytic site [active] 706191013190 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 706191013191 active site 706191013192 hexamer interface [polypeptide binding]; other site 706191013193 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 706191013194 NAD binding site [chemical binding]; other site 706191013195 substrate binding site [chemical binding]; other site 706191013196 active site 706191013197 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 706191013198 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 706191013199 putative active site [active] 706191013200 putative catalytic site [active] 706191013201 putative Zn binding site [ion binding]; other site 706191013202 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 706191013203 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 706191013204 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 706191013205 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 706191013206 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706191013207 dimerization interface [polypeptide binding]; other site 706191013208 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191013209 dimer interface [polypeptide binding]; other site 706191013210 putative CheW interface [polypeptide binding]; other site 706191013211 chorismate mutase; Provisional; Region: PRK08055 706191013212 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 706191013213 Putative glucoamylase; Region: Glycoamylase; pfam10091 706191013214 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 706191013215 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 706191013216 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 706191013217 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 706191013218 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 706191013219 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 706191013220 phosphate binding site [ion binding]; other site 706191013221 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 706191013222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191013223 Coenzyme A binding pocket [chemical binding]; other site 706191013224 Protein of unknown function, DUF606; Region: DUF606; pfam04657 706191013225 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 706191013226 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 706191013227 nucleotide binding site [chemical binding]; other site 706191013228 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 706191013229 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 706191013230 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 706191013231 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 706191013232 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 706191013233 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 706191013234 Domain interface; other site 706191013235 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 706191013236 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 706191013237 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 706191013238 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 706191013239 Domain of unknown function (DUF333); Region: DUF333; pfam03891 706191013240 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 706191013241 Predicted flavoprotein [General function prediction only]; Region: COG0431 706191013242 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 706191013243 flagellin; Provisional; Region: PRK12802 706191013244 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 706191013245 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 706191013246 flagellar capping protein; Reviewed; Region: fliD; PRK08032 706191013247 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 706191013248 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 706191013249 RES domain; Region: RES; pfam08808 706191013250 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 706191013251 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 706191013252 KTSC domain; Region: KTSC; pfam13619 706191013253 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 706191013254 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706191013255 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 706191013256 pyrimidine utilization protein A; Region: RutA; TIGR03612 706191013257 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 706191013258 active site 706191013259 dimer interface [polypeptide binding]; other site 706191013260 non-prolyl cis peptide bond; other site 706191013261 insertion regions; other site 706191013262 Isochorismatase family; Region: Isochorismatase; pfam00857 706191013263 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 706191013264 catalytic triad [active] 706191013265 conserved cis-peptide bond; other site 706191013266 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 706191013267 homotrimer interaction site [polypeptide binding]; other site 706191013268 putative active site [active] 706191013269 pyrimidine utilization protein D; Region: RutD; TIGR03611 706191013270 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 706191013271 putative FMN binding site [chemical binding]; other site 706191013272 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 706191013273 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 706191013274 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 706191013275 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 706191013276 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 706191013277 active site 706191013278 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 706191013279 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706191013280 Walker A/P-loop; other site 706191013281 ATP binding site [chemical binding]; other site 706191013282 Q-loop/lid; other site 706191013283 ABC transporter signature motif; other site 706191013284 Walker B; other site 706191013285 D-loop; other site 706191013286 H-loop/switch region; other site 706191013287 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 706191013288 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706191013289 Walker A/P-loop; other site 706191013290 ATP binding site [chemical binding]; other site 706191013291 Q-loop/lid; other site 706191013292 ABC transporter signature motif; other site 706191013293 Walker B; other site 706191013294 D-loop; other site 706191013295 H-loop/switch region; other site 706191013296 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 706191013297 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 706191013298 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 706191013299 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 706191013300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191013301 dimer interface [polypeptide binding]; other site 706191013302 conserved gate region; other site 706191013303 putative PBP binding loops; other site 706191013304 ABC-ATPase subunit interface; other site 706191013305 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 706191013306 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 706191013307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191013308 dimer interface [polypeptide binding]; other site 706191013309 conserved gate region; other site 706191013310 putative PBP binding loops; other site 706191013311 ABC-ATPase subunit interface; other site 706191013312 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 706191013313 homodimer interface [polypeptide binding]; other site 706191013314 homotetramer interface [polypeptide binding]; other site 706191013315 active site pocket [active] 706191013316 cleavage site 706191013317 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 706191013318 SxDxEG motif; other site 706191013319 active site 706191013320 metal binding site [ion binding]; metal-binding site 706191013321 homopentamer interface [polypeptide binding]; other site 706191013322 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191013323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191013324 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 706191013325 dimerization interface [polypeptide binding]; other site 706191013326 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 706191013327 PAS domain; Region: PAS_9; pfam13426 706191013328 putative active site [active] 706191013329 heme pocket [chemical binding]; other site 706191013330 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 706191013331 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706191013332 metal binding site [ion binding]; metal-binding site 706191013333 active site 706191013334 I-site; other site 706191013335 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 706191013336 Transcriptional regulators [Transcription]; Region: PurR; COG1609 706191013337 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191013338 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 706191013339 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 706191013340 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 706191013341 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 706191013342 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 706191013343 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 706191013344 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 706191013345 Metal-binding active site; metal-binding site 706191013346 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 706191013347 hydroxyglutarate oxidase; Provisional; Region: PRK11728 706191013348 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 706191013349 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706191013350 non-specific DNA binding site [nucleotide binding]; other site 706191013351 salt bridge; other site 706191013352 sequence-specific DNA binding site [nucleotide binding]; other site 706191013353 Cupin domain; Region: Cupin_2; pfam07883 706191013354 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 706191013355 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 706191013356 substrate binding pocket [chemical binding]; other site 706191013357 membrane-bound complex binding site; other site 706191013358 hinge residues; other site 706191013359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191013360 dimer interface [polypeptide binding]; other site 706191013361 conserved gate region; other site 706191013362 putative PBP binding loops; other site 706191013363 ABC-ATPase subunit interface; other site 706191013364 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 706191013365 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 706191013366 Walker A/P-loop; other site 706191013367 ATP binding site [chemical binding]; other site 706191013368 Q-loop/lid; other site 706191013369 ABC transporter signature motif; other site 706191013370 Walker B; other site 706191013371 D-loop; other site 706191013372 H-loop/switch region; other site 706191013373 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 706191013374 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191013375 dimer interface [polypeptide binding]; other site 706191013376 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 706191013377 putative CheW interface [polypeptide binding]; other site 706191013378 flagellin; Provisional; Region: PRK12802 706191013379 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 706191013380 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 706191013381 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 706191013382 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706191013383 dimerization interface [polypeptide binding]; other site 706191013384 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706191013385 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191013386 dimer interface [polypeptide binding]; other site 706191013387 putative CheW interface [polypeptide binding]; other site 706191013388 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 706191013389 active site 706191013390 DNA binding site [nucleotide binding] 706191013391 Int/Topo IB signature motif; other site 706191013392 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 706191013393 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706191013394 metal binding site [ion binding]; metal-binding site 706191013395 active site 706191013396 I-site; other site 706191013397 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 706191013398 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706191013399 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 706191013400 binding surface 706191013401 TPR motif; other site 706191013402 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 706191013403 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 706191013404 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 706191013405 HTH-like domain; Region: HTH_21; pfam13276 706191013406 Integrase core domain; Region: rve; pfam00665 706191013407 Integrase core domain; Region: rve_3; pfam13683 706191013408 Transposase; Region: HTH_Tnp_1; pfam01527 706191013409 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 706191013410 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 706191013411 urea carboxylase; Region: urea_carbox; TIGR02712 706191013412 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 706191013413 ATP-grasp domain; Region: ATP-grasp_4; cl17255 706191013414 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 706191013415 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 706191013416 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 706191013417 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 706191013418 carboxyltransferase (CT) interaction site; other site 706191013419 biotinylation site [posttranslational modification]; other site 706191013420 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 706191013421 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 706191013422 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 706191013423 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 706191013424 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 706191013425 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 706191013426 Walker A/P-loop; other site 706191013427 ATP binding site [chemical binding]; other site 706191013428 Q-loop/lid; other site 706191013429 ABC transporter signature motif; other site 706191013430 Walker B; other site 706191013431 D-loop; other site 706191013432 H-loop/switch region; other site 706191013433 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 706191013434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191013435 dimer interface [polypeptide binding]; other site 706191013436 conserved gate region; other site 706191013437 putative PBP binding loops; other site 706191013438 ABC-ATPase subunit interface; other site 706191013439 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 706191013440 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 706191013441 YkkD/YxkD leader; PANA_ncRNA9 706191013442 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 706191013443 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 706191013444 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 706191013445 aspartate racemase; Region: asp_race; TIGR00035 706191013446 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 706191013447 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 706191013448 DsbD alpha interface [polypeptide binding]; other site 706191013449 catalytic residues [active] 706191013450 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 706191013451 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 706191013452 catalytic triad [active] 706191013453 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 706191013454 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 706191013455 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 706191013456 dimerization interface [polypeptide binding]; other site 706191013457 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 706191013458 active site 706191013459 metal binding site [ion binding]; metal-binding site 706191013460 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 706191013461 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 706191013462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191013463 dimer interface [polypeptide binding]; other site 706191013464 conserved gate region; other site 706191013465 putative PBP binding loops; other site 706191013466 ABC-ATPase subunit interface; other site 706191013467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191013468 dimer interface [polypeptide binding]; other site 706191013469 conserved gate region; other site 706191013470 putative PBP binding loops; other site 706191013471 ABC-ATPase subunit interface; other site 706191013472 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 706191013473 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 706191013474 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 706191013475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 706191013476 Walker A/P-loop; other site 706191013477 ATP binding site [chemical binding]; other site 706191013478 Q-loop/lid; other site 706191013479 ABC transporter signature motif; other site 706191013480 Walker B; other site 706191013481 D-loop; other site 706191013482 H-loop/switch region; other site 706191013483 TOBE domain; Region: TOBE_2; pfam08402 706191013484 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706191013485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706191013486 EamA-like transporter family; Region: EamA; pfam00892 706191013487 EamA-like transporter family; Region: EamA; pfam00892 706191013488 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 706191013489 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 706191013490 dimerization interface [polypeptide binding]; other site 706191013491 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 706191013492 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 706191013493 dimer interface [polypeptide binding]; other site 706191013494 putative CheW interface [polypeptide binding]; other site 706191013495 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 706191013496 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 706191013497 LysE type translocator; Region: LysE; cl00565 706191013498 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 706191013499 dimer interface [polypeptide binding]; other site 706191013500 FMN binding site [chemical binding]; other site 706191013501 NADPH bind site [chemical binding]; other site 706191013502 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706191013503 metal binding site [ion binding]; metal-binding site 706191013504 active site 706191013505 I-site; other site 706191013506 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 706191013507 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 706191013508 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 706191013509 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 706191013510 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 706191013511 Cytochrome c; Region: Cytochrom_C; pfam00034 706191013512 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 706191013513 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 706191013514 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 706191013515 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 706191013516 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 706191013517 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 706191013518 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 706191013519 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 706191013520 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 706191013521 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 706191013522 inhibitor-cofactor binding pocket; inhibition site 706191013523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191013524 catalytic residue [active] 706191013525 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 706191013526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 706191013527 catalytic residue [active] 706191013528 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 706191013529 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 706191013530 malate:quinone oxidoreductase; Validated; Region: PRK05257 706191013531 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 706191013532 Uncharacterized conserved protein [Function unknown]; Region: COG5464 706191013533 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 706191013534 sensory histidine kinase DcuS; Provisional; Region: PRK11086 706191013535 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 706191013536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 706191013537 ATP binding site [chemical binding]; other site 706191013538 Mg2+ binding site [ion binding]; other site 706191013539 G-X-G motif; other site 706191013540 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 706191013541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 706191013542 active site 706191013543 phosphorylation site [posttranslational modification] 706191013544 intermolecular recognition site; other site 706191013545 dimerization interface [polypeptide binding]; other site 706191013546 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 706191013547 ApbE family; Region: ApbE; pfam02424 706191013548 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 706191013549 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 706191013550 putative active site [active] 706191013551 putative FMN binding site [chemical binding]; other site 706191013552 putative substrate binding site [chemical binding]; other site 706191013553 putative catalytic residue [active] 706191013554 FMN-binding domain; Region: FMN_bind; cl01081 706191013555 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 706191013556 L-aspartate oxidase; Provisional; Region: PRK06175 706191013557 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 706191013558 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 706191013559 transmembrane helices; other site 706191013560 fumarate hydratase; Provisional; Region: PRK15389 706191013561 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 706191013562 Fumarase C-terminus; Region: Fumerase_C; pfam05683 706191013563 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 706191013564 NADH(P)-binding; Region: NAD_binding_10; pfam13460 706191013565 NAD(P) binding site [chemical binding]; other site 706191013566 putative active site [active] 706191013567 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 706191013568 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 706191013569 NAD(P) binding site [chemical binding]; other site 706191013570 active site 706191013571 Transcriptional regulator [Transcription]; Region: LysR; COG0583 706191013572 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 706191013573 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 706191013574 dimerization interface [polypeptide binding]; other site 706191013575 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 706191013576 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 706191013577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191013578 Major Facilitator Superfamily; Region: MFS_1; pfam07690 706191013579 putative substrate translocation pore; other site 706191013580 proline/glycine betaine transporter; Provisional; Region: PRK10642 706191013581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 706191013582 putative substrate translocation pore; other site 706191013583 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 706191013584 substrate binding site [chemical binding]; other site 706191013585 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 706191013586 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 706191013587 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 706191013588 ImpA domain protein; Region: DUF3702; pfam12486 706191013589 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 706191013590 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 706191013591 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 706191013592 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 706191013593 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 706191013594 PAAR motif; Region: PAAR_motif; pfam05488 706191013595 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 706191013596 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 706191013597 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 706191013598 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 706191013599 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 706191013600 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 706191013601 Peptidase family M23; Region: Peptidase_M23; pfam01551 706191013602 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 706191013603 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 706191013604 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 706191013605 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 706191013606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 706191013607 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 706191013608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191013609 Walker A motif; other site 706191013610 ATP binding site [chemical binding]; other site 706191013611 Walker B motif; other site 706191013612 arginine finger; other site 706191013613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 706191013614 Walker A motif; other site 706191013615 ATP binding site [chemical binding]; other site 706191013616 Walker B motif; other site 706191013617 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 706191013618 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 706191013619 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 706191013620 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 706191013621 ligand binding site [chemical binding]; other site 706191013622 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 706191013623 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 706191013624 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 706191013625 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 706191013626 Protein of unknown function (DUF877); Region: DUF877; pfam05943 706191013627 Protein of unknown function (DUF770); Region: DUF770; pfam05591 706191013628 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 706191013629 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 706191013630 Cl- selectivity filter; other site 706191013631 Cl- binding residues [ion binding]; other site 706191013632 pore gating glutamate residue; other site 706191013633 dimer interface [polypeptide binding]; other site 706191013634 H+/Cl- coupling transport residue; other site 706191013635 glutaminase; Provisional; Region: PRK00971 706191013636 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 706191013637 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 706191013638 glycerate dehydrogenase; Provisional; Region: PRK06487 706191013639 putative ligand binding site [chemical binding]; other site 706191013640 putative NAD binding site [chemical binding]; other site 706191013641 catalytic site [active] 706191013642 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 706191013643 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 706191013644 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 706191013645 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 706191013646 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 706191013647 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 706191013648 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 706191013649 substrate binding pocket [chemical binding]; other site 706191013650 chain length determination region; other site 706191013651 substrate-Mg2+ binding site; other site 706191013652 catalytic residues [active] 706191013653 aspartate-rich region 1; other site 706191013654 active site lid residues [active] 706191013655 aspartate-rich region 2; other site 706191013656 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 706191013657 glycosyltransferase, MGT family; Region: MGT; TIGR01426 706191013658 active site 706191013659 TDP-binding site; other site 706191013660 acceptor substrate-binding pocket; other site 706191013661 homodimer interface [polypeptide binding]; other site 706191013662 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 706191013663 lycopene cyclase; Region: lycopene_cycl; TIGR01789 706191013664 phytoene desaturase; Region: crtI_fam; TIGR02734 706191013665 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 706191013666 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 706191013667 active site lid residues [active] 706191013668 substrate binding pocket [chemical binding]; other site 706191013669 catalytic residues [active] 706191013670 substrate-Mg2+ binding site; other site 706191013671 aspartate-rich region 1; other site 706191013672 aspartate-rich region 2; other site 706191013673 beta-carotene hydroxylase; Region: PLN02601 706191013674 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 706191013675 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 706191013676 putative NAD(P) binding site [chemical binding]; other site 706191013677 putative substrate binding site [chemical binding]; other site 706191013678 catalytic Zn binding site [ion binding]; other site 706191013679 structural Zn binding site [ion binding]; other site 706191013680 dimer interface [polypeptide binding]; other site 706191013681 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 706191013682 Thioredoxin; Region: Thioredoxin_4; cl17273 706191013683 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 706191013684 SnoaL-like domain; Region: SnoaL_3; pfam13474 706191013685 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 706191013686 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 706191013687 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 706191013688 LysE type translocator; Region: LysE; cl00565 706191013689 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 706191013690 Coenzyme A binding pocket [chemical binding]; other site 706191013691 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 706191013692 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 706191013693 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 706191013694 ATP binding site [chemical binding]; other site 706191013695 substrate interface [chemical binding]; other site 706191013696 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 706191013697 active site residue [active] 706191013698 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 706191013699 ThiS interaction site; other site 706191013700 putative active site [active] 706191013701 tetramer interface [polypeptide binding]; other site 706191013702 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 706191013703 thiS-thiF/thiG interaction site; other site 706191013704 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 706191013705 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 706191013706 AzlC protein; Region: AzlC; cl00570 706191013707 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 706191013708 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 706191013709 non-specific DNA binding site [nucleotide binding]; other site 706191013710 salt bridge; other site 706191013711 sequence-specific DNA binding site [nucleotide binding]; other site 706191013712 Cupin domain; Region: Cupin_2; cl17218 706191013713 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 706191013714 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706191013715 Walker A/P-loop; other site 706191013716 ATP binding site [chemical binding]; other site 706191013717 Q-loop/lid; other site 706191013718 ABC transporter signature motif; other site 706191013719 Walker B; other site 706191013720 D-loop; other site 706191013721 H-loop/switch region; other site 706191013722 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 706191013723 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 706191013724 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 706191013725 Walker A/P-loop; other site 706191013726 ATP binding site [chemical binding]; other site 706191013727 Q-loop/lid; other site 706191013728 ABC transporter signature motif; other site 706191013729 Walker B; other site 706191013730 D-loop; other site 706191013731 H-loop/switch region; other site 706191013732 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 706191013733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191013734 dimer interface [polypeptide binding]; other site 706191013735 conserved gate region; other site 706191013736 putative PBP binding loops; other site 706191013737 ABC-ATPase subunit interface; other site 706191013738 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 706191013739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 706191013740 dimer interface [polypeptide binding]; other site 706191013741 conserved gate region; other site 706191013742 putative PBP binding loops; other site 706191013743 ABC-ATPase subunit interface; other site 706191013744 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 706191013745 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 706191013746 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 706191013747 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 706191013748 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 706191013749 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 706191013750 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 706191013751 NAD(P) binding site [chemical binding]; other site 706191013752 catalytic residues [active] 706191013753 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 706191013754 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 706191013755 P-loop; other site 706191013756 Magnesium ion binding site [ion binding]; other site 706191013757 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 706191013758 Magnesium ion binding site [ion binding]; other site 706191013759 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 706191013760 ParB-like nuclease domain; Region: ParBc; pfam02195 706191013761 ParB family; Region: ParB; pfam08775 706191013762 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 706191013763 homotrimer interaction site [polypeptide binding]; other site 706191013764 putative active site [active] 706191013765 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 706191013766 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 706191013767 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 706191013768 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 706191013769 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 706191013770 metal binding site [ion binding]; metal-binding site 706191013771 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 706191013772 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 706191013773 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 706191013774 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 706191013775 ABC-ATPase subunit interface; other site 706191013776 dimer interface [polypeptide binding]; other site 706191013777 putative PBP binding regions; other site 706191013778 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 706191013779 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 706191013780 ABC-ATPase subunit interface; other site 706191013781 dimer interface [polypeptide binding]; other site 706191013782 putative PBP binding regions; other site 706191013783 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 706191013784 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 706191013785 catalytic loop [active] 706191013786 iron binding site [ion binding]; other site 706191013787 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 706191013788 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 706191013789 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 706191013790 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 706191013791 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 706191013792 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 706191013793 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 706191013794 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 706191013795 Ligand binding site; other site 706191013796 metal-binding site 706191013797 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 706191013798 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 706191013799 XdhC Rossmann domain; Region: XdhC_C; pfam13478 706191013800 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 706191013801 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 706191013802 putative ligand binding residues [chemical binding]; other site 706191013803 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 706191013804 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 706191013805 N-terminal plug; other site 706191013806 ligand-binding site [chemical binding]; other site 706191013807 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 706191013808 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 706191013809 putative active site [active] 706191013810 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 706191013811 active site 706191013812 oxyanion hole [active] 706191013813 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 706191013814 catalytic triad [active] 706191013815 Autotransporter beta-domain; Region: Autotransporter; cl17461 706191013816 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 706191013817 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 706191013818 RNA binding surface [nucleotide binding]; other site 706191013819 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 706191013820 probable active site [active] 706191013821 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 706191013822 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 706191013823 GAF domain; Region: GAF; pfam01590 706191013824 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 706191013825 Sensors of blue-light using FAD; Region: BLUF; pfam04940 706191013826 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 706191013827 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 706191013828 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 706191013829 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 706191013830 GAF domain; Region: GAF; pfam01590 706191013831 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 706191013832 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 706191013833 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 706191013834 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 706191013835 beta-galactosidase; Region: BGL; TIGR03356 706191013836 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 706191013837 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 706191013838 active site turn [active] 706191013839 phosphorylation site [posttranslational modification] 706191013840 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 706191013841 Transcriptional regulators [Transcription]; Region: PurR; COG1609 706191013842 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 706191013843 DNA binding site [nucleotide binding] 706191013844 domain linker motif; other site 706191013845 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 706191013846 dimerization interface (closed form) [polypeptide binding]; other site 706191013847 ligand binding site [chemical binding]; other site 706191013848 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 706191013849 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 706191013850 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 706191013851 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 706191013852 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 706191013853 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191013854 active site 706191013855 motif I; other site 706191013856 motif II; other site 706191013857 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 706191013858 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 706191013859 MASE2 domain; Region: MASE2; pfam05230 706191013860 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 706191013861 metal binding site [ion binding]; metal-binding site 706191013862 active site 706191013863 I-site; other site 706191013864 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 706191013865 active site 706191013866 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 706191013867 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 706191013868 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 706191013869 active site 706191013870 DNA binding site [nucleotide binding] 706191013871 Int/Topo IB signature motif; other site 706191013872 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 706191013873 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 706191013874 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 706191013875 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 706191013876 N-terminal plug; other site 706191013877 ligand-binding site [chemical binding]; other site