-- dump date 20140619_230812 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1095774000001 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1095774000002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1095774000003 P-loop; other site 1095774000004 Magnesium ion binding site [ion binding]; other site 1095774000005 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1095774000006 Magnesium ion binding site [ion binding]; other site 1095774000007 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1095774000008 ParB-like nuclease domain; Region: ParBc; pfam02195 1095774000009 ParB family; Region: ParB; pfam08775 1095774000010 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1095774000011 homotrimer interaction site [polypeptide binding]; other site 1095774000012 putative active site [active] 1095774000013 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1095774000014 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1095774000015 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1095774000016 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1095774000017 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1095774000018 metal binding site [ion binding]; metal-binding site 1095774000019 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 1095774000020 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1095774000021 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1095774000022 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1095774000023 ABC-ATPase subunit interface; other site 1095774000024 dimer interface [polypeptide binding]; other site 1095774000025 putative PBP binding regions; other site 1095774000026 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1095774000027 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1095774000028 ABC-ATPase subunit interface; other site 1095774000029 dimer interface [polypeptide binding]; other site 1095774000030 putative PBP binding regions; other site 1095774000031 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1095774000032 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1095774000033 catalytic loop [active] 1095774000034 iron binding site [ion binding]; other site 1095774000035 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1095774000036 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1095774000037 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1095774000038 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1095774000039 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1095774000040 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1095774000041 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1095774000042 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1095774000043 Ligand binding site; other site 1095774000044 metal-binding site 1095774000045 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1095774000046 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1095774000047 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1095774000048 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1095774000049 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 1095774000050 putative ligand binding residues [chemical binding]; other site 1095774000051 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1095774000052 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1095774000053 N-terminal plug; other site 1095774000054 ligand-binding site [chemical binding]; other site 1095774000055 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1095774000056 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1095774000057 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1095774000058 putative active site [active] 1095774000059 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1095774000060 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 1095774000061 active site 1095774000062 catalytic triad [active] 1095774000063 oxyanion hole [active] 1095774000064 Autotransporter beta-domain; Region: Autotransporter; cl17461 1095774000065 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 1095774000066 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1095774000067 RNA binding surface [nucleotide binding]; other site 1095774000068 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1095774000069 probable active site [active] 1095774000070 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1095774000071 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1095774000072 GAF domain; Region: GAF; pfam01590 1095774000073 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1095774000074 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1095774000075 Sensors of blue-light using FAD; Region: BLUF; pfam04940 1095774000076 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1095774000077 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1095774000078 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1095774000079 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1095774000080 GAF domain; Region: GAF; pfam01590 1095774000081 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1095774000082 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1095774000083 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1095774000084 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 1095774000085 beta-galactosidase; Region: BGL; TIGR03356 1095774000086 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 1095774000087 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1095774000088 active site turn [active] 1095774000089 phosphorylation site [posttranslational modification] 1095774000090 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1095774000091 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1095774000092 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774000093 DNA binding site [nucleotide binding] 1095774000094 domain linker motif; other site 1095774000095 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1095774000096 dimerization interface (closed form) [polypeptide binding]; other site 1095774000097 ligand binding site [chemical binding]; other site 1095774000098 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1095774000099 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1095774000100 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1095774000101 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1095774000102 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1095774000103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774000104 active site 1095774000105 motif I; other site 1095774000106 motif II; other site 1095774000107 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774000108 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1095774000109 MASE2 domain; Region: MASE2; pfam05230 1095774000110 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1095774000111 metal binding site [ion binding]; metal-binding site 1095774000112 active site 1095774000113 I-site; other site 1095774000114 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1095774000115 active site 1095774000116 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1095774000117 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 1095774000118 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1095774000119 active site 1095774000120 DNA binding site [nucleotide binding] 1095774000121 Int/Topo IB signature motif; other site 1095774000122 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1095774000123 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1095774000124 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 1095774000125 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1095774000126 N-terminal plug; other site 1095774000127 ligand-binding site [chemical binding]; other site 1095774000128 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1095774000129 active site 1095774000130 dimerization interface [polypeptide binding]; other site 1095774000131 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1095774000132 YebG protein; Region: YebG; pfam07130 1095774000133 Cupin domain; Region: Cupin_2; cl17218 1095774000134 Cache domain; Region: Cache_1; pfam02743 1095774000135 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1095774000136 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774000137 dimer interface [polypeptide binding]; other site 1095774000138 putative CheW interface [polypeptide binding]; other site 1095774000139 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1095774000140 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1095774000141 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1095774000142 NAD(P) binding site [chemical binding]; other site 1095774000143 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774000144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774000145 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1095774000146 putative dimerization interface [polypeptide binding]; other site 1095774000147 putative substrate binding pocket [chemical binding]; other site 1095774000148 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1095774000149 acetolactate synthase; Reviewed; Region: PRK08617 1095774000150 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1095774000151 PYR/PP interface [polypeptide binding]; other site 1095774000152 dimer interface [polypeptide binding]; other site 1095774000153 TPP binding site [chemical binding]; other site 1095774000154 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1095774000155 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1095774000156 TPP-binding site [chemical binding]; other site 1095774000157 acetoin reductase; Validated; Region: PRK08643 1095774000158 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1095774000159 NAD binding site [chemical binding]; other site 1095774000160 homotetramer interface [polypeptide binding]; other site 1095774000161 homodimer interface [polypeptide binding]; other site 1095774000162 active site 1095774000163 substrate binding site [chemical binding]; other site 1095774000164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 1095774000165 SnoaL-like domain; Region: SnoaL_2; pfam12680 1095774000166 riboflavin synthase subunit beta; Provisional; Region: PRK12419 1095774000167 active site 1095774000168 homopentamer interface [polypeptide binding]; other site 1095774000169 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1095774000170 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1095774000171 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1095774000172 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1095774000173 Cupin domain; Region: Cupin_2; cl17218 1095774000174 short chain dehydrogenase; Provisional; Region: PRK07577 1095774000175 classical (c) SDRs; Region: SDR_c; cd05233 1095774000176 NAD(P) binding site [chemical binding]; other site 1095774000177 active site 1095774000178 Domain of unknown function (DUF386); Region: DUF386; cl01047 1095774000179 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 1095774000180 BNR repeat-like domain; Region: BNR_2; pfam13088 1095774000181 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1095774000182 Na binding site [ion binding]; other site 1095774000183 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1095774000184 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1095774000185 inhibitor site; inhibition site 1095774000186 active site 1095774000187 dimer interface [polypeptide binding]; other site 1095774000188 catalytic residue [active] 1095774000189 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1095774000190 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1095774000191 active site 1095774000192 NAD binding site [chemical binding]; other site 1095774000193 metal binding site [ion binding]; metal-binding site 1095774000194 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 1095774000195 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1095774000196 tyrosine phenol-lyase; Provisional; Region: PRK13237 1095774000197 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 1095774000198 substrate binding site [chemical binding]; other site 1095774000199 tetramer interface [polypeptide binding]; other site 1095774000200 catalytic residue [active] 1095774000201 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 1095774000202 aromatic amino acid transport protein; Region: araaP; TIGR00837 1095774000203 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1095774000204 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1095774000205 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1095774000206 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1095774000207 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1095774000208 substrate binding pocket [chemical binding]; other site 1095774000209 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1095774000210 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1095774000211 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774000212 EamA-like transporter family; Region: EamA; pfam00892 1095774000213 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1095774000214 EamA-like transporter family; Region: EamA; pfam00892 1095774000215 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1095774000216 putative active site pocket [active] 1095774000217 dimerization interface [polypeptide binding]; other site 1095774000218 putative catalytic residue [active] 1095774000219 HAMP domain; Region: HAMP; pfam00672 1095774000220 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1095774000221 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774000222 dimer interface [polypeptide binding]; other site 1095774000223 putative CheW interface [polypeptide binding]; other site 1095774000224 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1095774000225 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1095774000226 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1095774000227 HlyD family secretion protein; Region: HlyD_3; pfam13437 1095774000228 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1095774000229 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1095774000230 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1095774000231 dimer interface [polypeptide binding]; other site 1095774000232 phosphorylation site [posttranslational modification] 1095774000233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774000234 ATP binding site [chemical binding]; other site 1095774000235 Mg2+ binding site [ion binding]; other site 1095774000236 G-X-G motif; other site 1095774000237 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1095774000238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774000239 active site 1095774000240 phosphorylation site [posttranslational modification] 1095774000241 intermolecular recognition site; other site 1095774000242 dimerization interface [polypeptide binding]; other site 1095774000243 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1095774000244 DNA binding site [nucleotide binding] 1095774000245 MltA-interacting protein MipA; Region: MipA; cl01504 1095774000246 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1095774000247 dimer interface [polypeptide binding]; other site 1095774000248 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1095774000249 ligand binding site [chemical binding]; other site 1095774000250 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1095774000251 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1095774000252 inhibitor-cofactor binding pocket; inhibition site 1095774000253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774000254 catalytic residue [active] 1095774000255 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1095774000256 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1095774000257 Ligand binding site; other site 1095774000258 Putative Catalytic site; other site 1095774000259 DXD motif; other site 1095774000260 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1095774000261 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1095774000262 active site 1095774000263 substrate binding site [chemical binding]; other site 1095774000264 cosubstrate binding site; other site 1095774000265 catalytic site [active] 1095774000266 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1095774000267 active site 1095774000268 hexamer interface [polypeptide binding]; other site 1095774000269 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1095774000270 NAD binding site [chemical binding]; other site 1095774000271 substrate binding site [chemical binding]; other site 1095774000272 active site 1095774000273 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1095774000274 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 1095774000275 putative active site [active] 1095774000276 putative catalytic site [active] 1095774000277 putative Zn binding site [ion binding]; other site 1095774000278 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1095774000279 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1095774000280 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1095774000281 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1095774000282 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774000283 dimerization interface [polypeptide binding]; other site 1095774000284 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774000285 dimer interface [polypeptide binding]; other site 1095774000286 putative CheW interface [polypeptide binding]; other site 1095774000287 chorismate mutase; Provisional; Region: PRK08055 1095774000288 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1095774000289 Putative glucoamylase; Region: Glycoamylase; pfam10091 1095774000290 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 1095774000291 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1095774000292 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 1095774000293 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1095774000294 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1095774000295 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1095774000296 nucleotide binding site [chemical binding]; other site 1095774000297 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 1095774000298 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1095774000299 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1095774000300 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1095774000301 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1095774000302 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 1095774000303 Domain interface; other site 1095774000304 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 1095774000305 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1095774000306 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1095774000307 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1095774000308 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1095774000309 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1095774000310 Predicted flavoprotein [General function prediction only]; Region: COG0431 1095774000311 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1095774000312 flagellin; Provisional; Region: PRK12802 1095774000313 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1095774000314 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1095774000315 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1095774000316 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1095774000317 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1095774000318 RES domain; Region: RES; pfam08808 1095774000319 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 1095774000320 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1095774000321 KTSC domain; Region: KTSC; pfam13619 1095774000322 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1095774000323 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1095774000324 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1095774000325 pyrimidine utilization protein A; Region: RutA; TIGR03612 1095774000326 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1095774000327 active site 1095774000328 dimer interface [polypeptide binding]; other site 1095774000329 non-prolyl cis peptide bond; other site 1095774000330 insertion regions; other site 1095774000331 Isochorismatase family; Region: Isochorismatase; pfam00857 1095774000332 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1095774000333 catalytic triad [active] 1095774000334 conserved cis-peptide bond; other site 1095774000335 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1095774000336 homotrimer interaction site [polypeptide binding]; other site 1095774000337 putative active site [active] 1095774000338 pyrimidine utilization protein D; Region: RutD; TIGR03611 1095774000339 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1095774000340 putative FMN binding site [chemical binding]; other site 1095774000341 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 1095774000342 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1095774000343 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 1095774000344 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1095774000345 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1095774000346 active site 1095774000347 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1095774000348 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1095774000349 Walker A/P-loop; other site 1095774000350 ATP binding site [chemical binding]; other site 1095774000351 Q-loop/lid; other site 1095774000352 ABC transporter signature motif; other site 1095774000353 Walker B; other site 1095774000354 D-loop; other site 1095774000355 H-loop/switch region; other site 1095774000356 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1095774000357 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1095774000358 Walker A/P-loop; other site 1095774000359 ATP binding site [chemical binding]; other site 1095774000360 Q-loop/lid; other site 1095774000361 ABC transporter signature motif; other site 1095774000362 Walker B; other site 1095774000363 D-loop; other site 1095774000364 H-loop/switch region; other site 1095774000365 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1095774000366 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1095774000367 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1095774000368 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1095774000369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774000370 dimer interface [polypeptide binding]; other site 1095774000371 conserved gate region; other site 1095774000372 putative PBP binding loops; other site 1095774000373 ABC-ATPase subunit interface; other site 1095774000374 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1095774000375 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1095774000376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774000377 dimer interface [polypeptide binding]; other site 1095774000378 conserved gate region; other site 1095774000379 putative PBP binding loops; other site 1095774000380 ABC-ATPase subunit interface; other site 1095774000381 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1095774000382 homodimer interface [polypeptide binding]; other site 1095774000383 homotetramer interface [polypeptide binding]; other site 1095774000384 active site pocket [active] 1095774000385 cleavage site 1095774000386 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 1095774000387 SxDxEG motif; other site 1095774000388 active site 1095774000389 metal binding site [ion binding]; metal-binding site 1095774000390 homopentamer interface [polypeptide binding]; other site 1095774000391 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774000392 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774000393 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1095774000394 dimerization interface [polypeptide binding]; other site 1095774000395 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1095774000396 PAS domain; Region: PAS_9; pfam13426 1095774000397 putative active site [active] 1095774000398 heme pocket [chemical binding]; other site 1095774000399 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1095774000400 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1095774000401 metal binding site [ion binding]; metal-binding site 1095774000402 active site 1095774000403 I-site; other site 1095774000404 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1095774000405 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1095774000406 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774000407 domain linker motif; other site 1095774000408 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1095774000409 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1095774000410 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1095774000411 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1095774000412 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1095774000413 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1095774000414 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1095774000415 Metal-binding active site; metal-binding site 1095774000416 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1095774000417 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1095774000418 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1095774000419 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1095774000420 non-specific DNA binding site [nucleotide binding]; other site 1095774000421 salt bridge; other site 1095774000422 sequence-specific DNA binding site [nucleotide binding]; other site 1095774000423 Cupin domain; Region: Cupin_2; pfam07883 1095774000424 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774000425 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1095774000426 substrate binding pocket [chemical binding]; other site 1095774000427 membrane-bound complex binding site; other site 1095774000428 hinge residues; other site 1095774000429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774000430 dimer interface [polypeptide binding]; other site 1095774000431 conserved gate region; other site 1095774000432 putative PBP binding loops; other site 1095774000433 ABC-ATPase subunit interface; other site 1095774000434 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1095774000435 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1095774000436 Walker A/P-loop; other site 1095774000437 ATP binding site [chemical binding]; other site 1095774000438 Q-loop/lid; other site 1095774000439 ABC transporter signature motif; other site 1095774000440 Walker B; other site 1095774000441 D-loop; other site 1095774000442 H-loop/switch region; other site 1095774000443 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1095774000444 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774000445 dimer interface [polypeptide binding]; other site 1095774000446 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1095774000447 putative CheW interface [polypeptide binding]; other site 1095774000448 flagellin; Provisional; Region: PRK12802 1095774000449 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1095774000450 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1095774000451 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1095774000452 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774000453 dimerization interface [polypeptide binding]; other site 1095774000454 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1095774000455 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774000456 dimer interface [polypeptide binding]; other site 1095774000457 putative CheW interface [polypeptide binding]; other site 1095774000458 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1095774000459 urea carboxylase; Region: urea_carbox; TIGR02712 1095774000460 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1095774000461 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1095774000462 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1095774000463 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1095774000464 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1095774000465 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1095774000466 carboxyltransferase (CT) interaction site; other site 1095774000467 biotinylation site [posttranslational modification]; other site 1095774000468 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1095774000469 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1095774000470 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 1095774000471 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1095774000472 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1095774000473 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1095774000474 Walker A/P-loop; other site 1095774000475 ATP binding site [chemical binding]; other site 1095774000476 Q-loop/lid; other site 1095774000477 ABC transporter signature motif; other site 1095774000478 Walker B; other site 1095774000479 D-loop; other site 1095774000480 H-loop/switch region; other site 1095774000481 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1095774000482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774000483 dimer interface [polypeptide binding]; other site 1095774000484 conserved gate region; other site 1095774000485 putative PBP binding loops; other site 1095774000486 ABC-ATPase subunit interface; other site 1095774000487 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1095774000488 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1095774000489 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1095774000490 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 1095774000491 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1095774000492 aspartate racemase; Region: asp_race; TIGR00035 1095774000493 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 1095774000494 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1095774000495 DsbD alpha interface [polypeptide binding]; other site 1095774000496 catalytic residues [active] 1095774000497 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1095774000498 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1095774000499 catalytic triad [active] 1095774000500 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 1095774000501 nudix motif; other site 1095774000502 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774000503 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774000504 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1095774000505 dimerization interface [polypeptide binding]; other site 1095774000506 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1095774000507 active site 1095774000508 metal binding site [ion binding]; metal-binding site 1095774000509 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1095774000510 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1095774000511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774000512 dimer interface [polypeptide binding]; other site 1095774000513 conserved gate region; other site 1095774000514 putative PBP binding loops; other site 1095774000515 ABC-ATPase subunit interface; other site 1095774000516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1095774000517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774000518 putative PBP binding loops; other site 1095774000519 ABC-ATPase subunit interface; other site 1095774000520 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1095774000521 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1095774000522 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1095774000523 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774000524 Walker A/P-loop; other site 1095774000525 ATP binding site [chemical binding]; other site 1095774000526 Q-loop/lid; other site 1095774000527 ABC transporter signature motif; other site 1095774000528 Walker B; other site 1095774000529 D-loop; other site 1095774000530 H-loop/switch region; other site 1095774000531 TOBE domain; Region: TOBE_2; pfam08402 1095774000532 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1095774000533 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1095774000534 EamA-like transporter family; Region: EamA; cl17759 1095774000535 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1095774000536 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774000537 dimerization interface [polypeptide binding]; other site 1095774000538 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1095774000539 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774000540 dimer interface [polypeptide binding]; other site 1095774000541 putative CheW interface [polypeptide binding]; other site 1095774000542 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1095774000543 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1095774000544 LysE type translocator; Region: LysE; cl00565 1095774000545 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1095774000546 dimer interface [polypeptide binding]; other site 1095774000547 FMN binding site [chemical binding]; other site 1095774000548 NADPH bind site [chemical binding]; other site 1095774000549 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1095774000550 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1095774000551 metal binding site [ion binding]; metal-binding site 1095774000552 active site 1095774000553 I-site; other site 1095774000554 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1095774000555 Cytochrome c; Region: Cytochrom_C; cl11414 1095774000556 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1095774000557 Cytochrome c; Region: Cytochrom_C; pfam00034 1095774000558 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1095774000559 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1095774000560 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1095774000561 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 1095774000562 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1095774000563 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1095774000564 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1095774000565 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 1095774000566 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1095774000567 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1095774000568 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1095774000569 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 1095774000570 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1095774000571 inhibitor-cofactor binding pocket; inhibition site 1095774000572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774000573 catalytic residue [active] 1095774000574 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1095774000575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774000576 catalytic residue [active] 1095774000577 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 1095774000578 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 1095774000579 malate:quinone oxidoreductase; Validated; Region: PRK05257 1095774000580 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1095774000581 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1095774000582 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1095774000583 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1095774000584 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1095774000585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774000586 ATP binding site [chemical binding]; other site 1095774000587 Mg2+ binding site [ion binding]; other site 1095774000588 G-X-G motif; other site 1095774000589 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1095774000590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774000591 active site 1095774000592 phosphorylation site [posttranslational modification] 1095774000593 intermolecular recognition site; other site 1095774000594 dimerization interface [polypeptide binding]; other site 1095774000595 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1095774000596 ApbE family; Region: ApbE; pfam02424 1095774000597 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1095774000598 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1095774000599 putative active site [active] 1095774000600 putative FMN binding site [chemical binding]; other site 1095774000601 putative substrate binding site [chemical binding]; other site 1095774000602 putative catalytic residue [active] 1095774000603 FMN-binding domain; Region: FMN_bind; cl01081 1095774000604 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1095774000605 L-aspartate oxidase; Provisional; Region: PRK06175 1095774000606 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1095774000607 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1095774000608 transmembrane helices; other site 1095774000609 fumarate hydratase; Provisional; Region: PRK15389 1095774000610 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1095774000611 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1095774000612 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1095774000613 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1095774000614 NAD(P) binding site [chemical binding]; other site 1095774000615 putative active site [active] 1095774000616 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 1095774000617 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1095774000618 NAD(P) binding site [chemical binding]; other site 1095774000619 active site 1095774000620 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774000621 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774000622 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1095774000623 dimerization interface [polypeptide binding]; other site 1095774000624 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 1095774000625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774000626 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1095774000627 putative substrate translocation pore; other site 1095774000628 proline/glycine betaine transporter; Provisional; Region: PRK10642 1095774000629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774000630 putative substrate translocation pore; other site 1095774000631 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1095774000632 substrate binding site [chemical binding]; other site 1095774000633 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1095774000634 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1095774000635 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1095774000636 Cl- selectivity filter; other site 1095774000637 Cl- binding residues [ion binding]; other site 1095774000638 pore gating glutamate residue; other site 1095774000639 dimer interface [polypeptide binding]; other site 1095774000640 H+/Cl- coupling transport residue; other site 1095774000641 glutaminase; Provisional; Region: PRK00971 1095774000642 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1095774000643 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1095774000644 glycerate dehydrogenase; Provisional; Region: PRK06487 1095774000645 putative ligand binding site [chemical binding]; other site 1095774000646 putative NAD binding site [chemical binding]; other site 1095774000647 catalytic site [active] 1095774000648 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 1095774000649 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1095774000650 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1095774000651 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 1095774000652 Helix-turn-helix domain; Region: HTH_17; pfam12728 1095774000653 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 1095774000654 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1095774000655 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1095774000656 substrate binding pocket [chemical binding]; other site 1095774000657 chain length determination region; other site 1095774000658 substrate-Mg2+ binding site; other site 1095774000659 catalytic residues [active] 1095774000660 aspartate-rich region 1; other site 1095774000661 active site lid residues [active] 1095774000662 aspartate-rich region 2; other site 1095774000663 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1095774000664 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1095774000665 active site 1095774000666 TDP-binding site; other site 1095774000667 acceptor substrate-binding pocket; other site 1095774000668 homodimer interface [polypeptide binding]; other site 1095774000669 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 1095774000670 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1095774000671 phytoene desaturase; Region: crtI_fam; TIGR02734 1095774000672 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1095774000673 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1095774000674 active site lid residues [active] 1095774000675 substrate binding pocket [chemical binding]; other site 1095774000676 catalytic residues [active] 1095774000677 substrate-Mg2+ binding site; other site 1095774000678 aspartate-rich region 1; other site 1095774000679 aspartate-rich region 2; other site 1095774000680 beta-carotene hydroxylase; Region: PLN02601 1095774000681 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1095774000682 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1095774000683 putative NAD(P) binding site [chemical binding]; other site 1095774000684 putative substrate binding site [chemical binding]; other site 1095774000685 catalytic Zn binding site [ion binding]; other site 1095774000686 structural Zn binding site [ion binding]; other site 1095774000687 dimer interface [polypeptide binding]; other site 1095774000688 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1095774000689 Thioredoxin; Region: Thioredoxin_4; cl17273 1095774000690 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1095774000691 SnoaL-like domain; Region: SnoaL_3; pfam13474 1095774000692 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1095774000693 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1095774000694 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1095774000695 LysE type translocator; Region: LysE; cl00565 1095774000696 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774000697 Coenzyme A binding pocket [chemical binding]; other site 1095774000698 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1095774000699 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 1095774000700 ATP binding site [chemical binding]; other site 1095774000701 substrate interface [chemical binding]; other site 1095774000702 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1095774000703 active site residue [active] 1095774000704 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1095774000705 ThiS interaction site; other site 1095774000706 putative active site [active] 1095774000707 tetramer interface [polypeptide binding]; other site 1095774000708 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1095774000709 thiS-thiF/thiG interaction site; other site 1095774000710 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1095774000711 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1095774000712 AzlC protein; Region: AzlC; cl00570 1095774000713 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1095774000714 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1095774000715 non-specific DNA binding site [nucleotide binding]; other site 1095774000716 salt bridge; other site 1095774000717 sequence-specific DNA binding site [nucleotide binding]; other site 1095774000718 Cupin domain; Region: Cupin_2; cl17218 1095774000719 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1095774000720 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1095774000721 Walker A/P-loop; other site 1095774000722 ATP binding site [chemical binding]; other site 1095774000723 Q-loop/lid; other site 1095774000724 ABC transporter signature motif; other site 1095774000725 Walker B; other site 1095774000726 D-loop; other site 1095774000727 H-loop/switch region; other site 1095774000728 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1095774000729 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1095774000730 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1095774000731 Walker A/P-loop; other site 1095774000732 ATP binding site [chemical binding]; other site 1095774000733 Q-loop/lid; other site 1095774000734 ABC transporter signature motif; other site 1095774000735 Walker B; other site 1095774000736 D-loop; other site 1095774000737 H-loop/switch region; other site 1095774000738 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1095774000739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774000740 dimer interface [polypeptide binding]; other site 1095774000741 conserved gate region; other site 1095774000742 putative PBP binding loops; other site 1095774000743 ABC-ATPase subunit interface; other site 1095774000744 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1095774000745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774000746 dimer interface [polypeptide binding]; other site 1095774000747 conserved gate region; other site 1095774000748 putative PBP binding loops; other site 1095774000749 ABC-ATPase subunit interface; other site 1095774000750 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1095774000751 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 1095774000752 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1095774000753 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1095774000754 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1095774000755 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1095774000756 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1095774000757 NAD(P) binding site [chemical binding]; other site 1095774000758 catalytic residues [active] 1095774000759 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1095774000760 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1095774000761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774000762 Walker A motif; other site 1095774000763 ATP binding site [chemical binding]; other site 1095774000764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1095774000765 Walker B motif; other site 1095774000766 arginine finger; other site 1095774000767 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1095774000768 DnaA box-binding interface [nucleotide binding]; other site 1095774000769 DNA polymerase III subunit beta; Validated; Region: PRK05643 1095774000770 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1095774000771 putative DNA binding surface [nucleotide binding]; other site 1095774000772 dimer interface [polypeptide binding]; other site 1095774000773 beta-clamp/clamp loader binding surface; other site 1095774000774 beta-clamp/translesion DNA polymerase binding surface; other site 1095774000775 recF protein; Region: recf; TIGR00611 1095774000776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774000777 Walker A/P-loop; other site 1095774000778 ATP binding site [chemical binding]; other site 1095774000779 Q-loop/lid; other site 1095774000780 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774000781 ABC transporter signature motif; other site 1095774000782 Walker B; other site 1095774000783 D-loop; other site 1095774000784 H-loop/switch region; other site 1095774000785 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1095774000786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774000787 Mg2+ binding site [ion binding]; other site 1095774000788 G-X-G motif; other site 1095774000789 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1095774000790 anchoring element; other site 1095774000791 dimer interface [polypeptide binding]; other site 1095774000792 ATP binding site [chemical binding]; other site 1095774000793 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1095774000794 active site 1095774000795 putative metal-binding site [ion binding]; other site 1095774000796 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1095774000797 sugar phosphate phosphatase; Provisional; Region: PRK10513 1095774000798 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774000799 active site 1095774000800 motif I; other site 1095774000801 motif II; other site 1095774000802 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774000803 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1095774000804 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1095774000805 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 1095774000806 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1095774000807 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1095774000808 putative dimer interface [polypeptide binding]; other site 1095774000809 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1095774000810 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1095774000811 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1095774000812 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 1095774000813 active site 1095774000814 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1095774000815 EamA-like transporter family; Region: EamA; pfam00892 1095774000816 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1095774000817 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1095774000818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774000819 homodimer interface [polypeptide binding]; other site 1095774000820 catalytic residue [active] 1095774000821 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1095774000822 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1095774000823 dimerization interface [polypeptide binding]; other site 1095774000824 ligand binding site [chemical binding]; other site 1095774000825 NADP binding site [chemical binding]; other site 1095774000826 catalytic site [active] 1095774000827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774000828 D-galactonate transporter; Region: 2A0114; TIGR00893 1095774000829 putative substrate translocation pore; other site 1095774000830 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1095774000831 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1095774000832 substrate binding site [chemical binding]; other site 1095774000833 ATP binding site [chemical binding]; other site 1095774000834 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1095774000835 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1095774000836 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774000837 DNA binding site [nucleotide binding] 1095774000838 domain linker motif; other site 1095774000839 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1095774000840 putative dimerization interface [polypeptide binding]; other site 1095774000841 putative ligand binding site [chemical binding]; other site 1095774000842 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1095774000843 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774000844 DNA binding site [nucleotide binding] 1095774000845 domain linker motif; other site 1095774000846 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 1095774000847 ligand binding site [chemical binding]; other site 1095774000848 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1095774000849 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1095774000850 ligand binding site [chemical binding]; other site 1095774000851 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1095774000852 primosomal protein DnaI; Provisional; Region: PRK02854 1095774000853 DNA replication protein DnaC; Validated; Region: PRK07952 1095774000854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774000855 Walker A motif; other site 1095774000856 ATP binding site [chemical binding]; other site 1095774000857 Walker B motif; other site 1095774000858 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1095774000859 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1095774000860 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1095774000861 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774000862 DNA binding site [nucleotide binding] 1095774000863 domain linker motif; other site 1095774000864 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1095774000865 ligand binding site [chemical binding]; other site 1095774000866 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1095774000867 active site 1095774000868 P-loop; other site 1095774000869 phosphorylation site [posttranslational modification] 1095774000870 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1095774000871 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1095774000872 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1095774000873 beta-galactosidase; Region: BGL; TIGR03356 1095774000874 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1095774000875 methionine cluster; other site 1095774000876 active site 1095774000877 phosphorylation site [posttranslational modification] 1095774000878 metal binding site [ion binding]; metal-binding site 1095774000879 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1095774000880 citrate-proton symporter; Provisional; Region: PRK15075 1095774000881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774000882 putative substrate translocation pore; other site 1095774000883 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1095774000884 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1095774000885 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774000886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774000887 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1095774000888 putative dimerization interface [polypeptide binding]; other site 1095774000889 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1095774000890 PAS domain; Region: PAS_9; pfam13426 1095774000891 putative active site [active] 1095774000892 heme pocket [chemical binding]; other site 1095774000893 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1095774000894 PAS domain; Region: PAS_9; pfam13426 1095774000895 putative active site [active] 1095774000896 heme pocket [chemical binding]; other site 1095774000897 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774000898 dimer interface [polypeptide binding]; other site 1095774000899 putative CheW interface [polypeptide binding]; other site 1095774000900 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1095774000901 Putative motility protein; Region: YjfB_motility; pfam14070 1095774000902 outer membrane protease; Reviewed; Region: PRK10993 1095774000903 OsmC-like protein; Region: OsmC; cl00767 1095774000904 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 1095774000905 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1095774000906 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1095774000907 putative active site [active] 1095774000908 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1095774000909 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1095774000910 TM-ABC transporter signature motif; other site 1095774000911 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1095774000912 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1095774000913 TM-ABC transporter signature motif; other site 1095774000914 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1095774000915 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1095774000916 Walker A/P-loop; other site 1095774000917 ATP binding site [chemical binding]; other site 1095774000918 Q-loop/lid; other site 1095774000919 ABC transporter signature motif; other site 1095774000920 Walker B; other site 1095774000921 D-loop; other site 1095774000922 H-loop/switch region; other site 1095774000923 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1095774000924 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1095774000925 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1095774000926 ligand binding site [chemical binding]; other site 1095774000927 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 1095774000928 active site 1095774000929 catalytic residues [active] 1095774000930 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1095774000931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774000932 Coenzyme A binding pocket [chemical binding]; other site 1095774000933 UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082 1095774000934 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1095774000935 putative dimerization interface [polypeptide binding]; other site 1095774000936 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1095774000937 putative ligand binding site [chemical binding]; other site 1095774000938 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774000939 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1095774000940 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774000941 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1095774000942 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1095774000943 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1095774000944 TM-ABC transporter signature motif; other site 1095774000945 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1095774000946 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1095774000947 Walker A/P-loop; other site 1095774000948 ATP binding site [chemical binding]; other site 1095774000949 Q-loop/lid; other site 1095774000950 ABC transporter signature motif; other site 1095774000951 Walker B; other site 1095774000952 D-loop; other site 1095774000953 H-loop/switch region; other site 1095774000954 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1095774000955 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 1095774000956 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1095774000957 putative ligand binding site [chemical binding]; other site 1095774000958 xylose isomerase; Provisional; Region: PRK05474 1095774000959 xylose isomerase; Region: xylose_isom_A; TIGR02630 1095774000960 xylulokinase; Provisional; Region: PRK15027 1095774000961 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1095774000962 N- and C-terminal domain interface [polypeptide binding]; other site 1095774000963 active site 1095774000964 MgATP binding site [chemical binding]; other site 1095774000965 catalytic site [active] 1095774000966 metal binding site [ion binding]; metal-binding site 1095774000967 xylulose binding site [chemical binding]; other site 1095774000968 homodimer interface [polypeptide binding]; other site 1095774000969 benzoate transport; Region: 2A0115; TIGR00895 1095774000970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774000971 putative substrate translocation pore; other site 1095774000972 transcriptional regulator PhoU; Provisional; Region: PRK11115 1095774000973 PhoU domain; Region: PhoU; pfam01895 1095774000974 PhoU domain; Region: PhoU; pfam01895 1095774000975 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1095774000976 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1095774000977 Walker A/P-loop; other site 1095774000978 ATP binding site [chemical binding]; other site 1095774000979 Q-loop/lid; other site 1095774000980 ABC transporter signature motif; other site 1095774000981 Walker B; other site 1095774000982 D-loop; other site 1095774000983 H-loop/switch region; other site 1095774000984 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1095774000985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774000986 dimer interface [polypeptide binding]; other site 1095774000987 conserved gate region; other site 1095774000988 putative PBP binding loops; other site 1095774000989 ABC-ATPase subunit interface; other site 1095774000990 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1095774000991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774000992 dimer interface [polypeptide binding]; other site 1095774000993 conserved gate region; other site 1095774000994 putative PBP binding loops; other site 1095774000995 ABC-ATPase subunit interface; other site 1095774000996 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774000997 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1095774000998 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1095774000999 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1095774001000 glutaminase active site [active] 1095774001001 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1095774001002 dimer interface [polypeptide binding]; other site 1095774001003 active site 1095774001004 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1095774001005 dimer interface [polypeptide binding]; other site 1095774001006 active site 1095774001007 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1095774001008 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1095774001009 Substrate binding site; other site 1095774001010 Mg++ binding site; other site 1095774001011 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1095774001012 active site 1095774001013 substrate binding site [chemical binding]; other site 1095774001014 CoA binding site [chemical binding]; other site 1095774001015 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1095774001016 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1095774001017 gamma subunit interface [polypeptide binding]; other site 1095774001018 epsilon subunit interface [polypeptide binding]; other site 1095774001019 LBP interface [polypeptide binding]; other site 1095774001020 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1095774001021 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1095774001022 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1095774001023 alpha subunit interaction interface [polypeptide binding]; other site 1095774001024 Walker A motif; other site 1095774001025 ATP binding site [chemical binding]; other site 1095774001026 Walker B motif; other site 1095774001027 inhibitor binding site; inhibition site 1095774001028 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1095774001029 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1095774001030 core domain interface [polypeptide binding]; other site 1095774001031 delta subunit interface [polypeptide binding]; other site 1095774001032 epsilon subunit interface [polypeptide binding]; other site 1095774001033 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1095774001034 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1095774001035 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1095774001036 Walker A motif; other site 1095774001037 ATP binding site [chemical binding]; other site 1095774001038 Walker B motif; other site 1095774001039 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1095774001040 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1095774001041 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1095774001042 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1095774001043 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1095774001044 ATP synthase, F0 subunit c; Region: ATP_synt_c; TIGR01260 1095774001045 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1095774001046 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1095774001047 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 1095774001048 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1095774001049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774001050 S-adenosylmethionine binding site [chemical binding]; other site 1095774001051 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1095774001052 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1095774001053 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1095774001054 FMN-binding protein MioC; Provisional; Region: PRK09004 1095774001055 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1095774001056 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1095774001057 putative DNA binding site [nucleotide binding]; other site 1095774001058 putative Zn2+ binding site [ion binding]; other site 1095774001059 AsnC family; Region: AsnC_trans_reg; pfam01037 1095774001060 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 1095774001061 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1095774001062 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1095774001063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774001064 S-adenosylmethionine binding site [chemical binding]; other site 1095774001065 hypothetical protein; Provisional; Region: yieM; PRK10997 1095774001066 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1095774001067 metal ion-dependent adhesion site (MIDAS); other site 1095774001068 regulatory ATPase RavA; Provisional; Region: PRK13531 1095774001069 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774001070 Walker A motif; other site 1095774001071 ATP binding site [chemical binding]; other site 1095774001072 Walker B motif; other site 1095774001073 arginine finger; other site 1095774001074 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1095774001075 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1095774001076 potassium uptake protein; Region: kup; TIGR00794 1095774001077 sensor protein QseC; Provisional; Region: PRK10337 1095774001078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1095774001079 dimer interface [polypeptide binding]; other site 1095774001080 phosphorylation site [posttranslational modification] 1095774001081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774001082 ATP binding site [chemical binding]; other site 1095774001083 Mg2+ binding site [ion binding]; other site 1095774001084 G-X-G motif; other site 1095774001085 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1095774001086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774001087 active site 1095774001088 phosphorylation site [posttranslational modification] 1095774001089 intermolecular recognition site; other site 1095774001090 dimerization interface [polypeptide binding]; other site 1095774001091 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1095774001092 DNA binding site [nucleotide binding] 1095774001093 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1095774001094 D-ribose pyranase; Provisional; Region: PRK11797 1095774001095 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1095774001096 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1095774001097 Walker A/P-loop; other site 1095774001098 ATP binding site [chemical binding]; other site 1095774001099 Q-loop/lid; other site 1095774001100 ABC transporter signature motif; other site 1095774001101 Walker B; other site 1095774001102 D-loop; other site 1095774001103 H-loop/switch region; other site 1095774001104 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1095774001105 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1095774001106 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1095774001107 TM-ABC transporter signature motif; other site 1095774001108 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1095774001109 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1095774001110 ligand binding site [chemical binding]; other site 1095774001111 dimerization interface [polypeptide binding]; other site 1095774001112 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1095774001113 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1095774001114 substrate binding site [chemical binding]; other site 1095774001115 dimer interface [polypeptide binding]; other site 1095774001116 ATP binding site [chemical binding]; other site 1095774001117 transcriptional repressor RbsR; Provisional; Region: PRK10423 1095774001118 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774001119 DNA binding site [nucleotide binding] 1095774001120 domain linker motif; other site 1095774001121 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1095774001122 dimerization interface [polypeptide binding]; other site 1095774001123 ligand binding site [chemical binding]; other site 1095774001124 putative transporter; Provisional; Region: PRK10504 1095774001125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774001126 putative substrate translocation pore; other site 1095774001127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774001128 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1095774001129 Walker A motif; other site 1095774001130 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1095774001131 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1095774001132 GTP binding site; other site 1095774001133 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 1095774001134 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1095774001135 serine/threonine protein kinase; Provisional; Region: PRK11768 1095774001136 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1095774001137 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1095774001138 catalytic residues [active] 1095774001139 hinge region; other site 1095774001140 alpha helical domain; other site 1095774001141 DNA polymerase I; Provisional; Region: PRK05755 1095774001142 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1095774001143 active site 1095774001144 metal binding site 1 [ion binding]; metal-binding site 1095774001145 putative 5' ssDNA interaction site; other site 1095774001146 metal binding site 3; metal-binding site 1095774001147 metal binding site 2 [ion binding]; metal-binding site 1095774001148 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1095774001149 putative DNA binding site [nucleotide binding]; other site 1095774001150 putative metal binding site [ion binding]; other site 1095774001151 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1095774001152 active site 1095774001153 catalytic site [active] 1095774001154 substrate binding site [chemical binding]; other site 1095774001155 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1095774001156 active site 1095774001157 DNA binding site [nucleotide binding] 1095774001158 catalytic site [active] 1095774001159 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1095774001160 G1 box; other site 1095774001161 GTP/Mg2+ binding site [chemical binding]; other site 1095774001162 Switch I region; other site 1095774001163 G2 box; other site 1095774001164 G3 box; other site 1095774001165 Switch II region; other site 1095774001166 G4 box; other site 1095774001167 G5 box; other site 1095774001168 Der GTPase activator; Provisional; Region: PRK05244 1095774001169 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1095774001170 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1095774001171 FeS/SAM binding site; other site 1095774001172 HemN C-terminal domain; Region: HemN_C; pfam06969 1095774001173 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1095774001174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774001175 active site 1095774001176 phosphorylation site [posttranslational modification] 1095774001177 intermolecular recognition site; other site 1095774001178 dimerization interface [polypeptide binding]; other site 1095774001179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774001180 Walker A motif; other site 1095774001181 ATP binding site [chemical binding]; other site 1095774001182 Walker B motif; other site 1095774001183 arginine finger; other site 1095774001184 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1095774001185 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1095774001186 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1095774001187 putative active site [active] 1095774001188 heme pocket [chemical binding]; other site 1095774001189 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1095774001190 dimer interface [polypeptide binding]; other site 1095774001191 phosphorylation site [posttranslational modification] 1095774001192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774001193 ATP binding site [chemical binding]; other site 1095774001194 Mg2+ binding site [ion binding]; other site 1095774001195 G-X-G motif; other site 1095774001196 glutamine synthetase; Provisional; Region: glnA; PRK09469 1095774001197 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1095774001198 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1095774001199 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1095774001200 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1095774001201 G1 box; other site 1095774001202 putative GEF interaction site [polypeptide binding]; other site 1095774001203 GTP/Mg2+ binding site [chemical binding]; other site 1095774001204 Switch I region; other site 1095774001205 G2 box; other site 1095774001206 G3 box; other site 1095774001207 Switch II region; other site 1095774001208 G4 box; other site 1095774001209 G5 box; other site 1095774001210 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1095774001211 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1095774001212 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1095774001213 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774001214 motif II; other site 1095774001215 hypothetical protein; Reviewed; Region: PRK01637 1095774001216 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1095774001217 putative active site [active] 1095774001218 dimerization interface [polypeptide binding]; other site 1095774001219 putative tRNAtyr binding site [nucleotide binding]; other site 1095774001220 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774001221 Coenzyme A binding pocket [chemical binding]; other site 1095774001222 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1095774001223 AsmA family; Region: AsmA; pfam05170 1095774001224 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1095774001225 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1095774001226 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1095774001227 Y-family of DNA polymerases; Region: PolY; cl12025 1095774001228 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1095774001229 generic binding surface II; other site 1095774001230 ssDNA binding site; other site 1095774001231 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1095774001232 ATP binding site [chemical binding]; other site 1095774001233 putative Mg++ binding site [ion binding]; other site 1095774001234 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1095774001235 nucleotide binding region [chemical binding]; other site 1095774001236 ATP-binding site [chemical binding]; other site 1095774001237 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1095774001238 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1095774001239 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1095774001240 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1095774001241 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1095774001242 Zn2+ binding site [ion binding]; other site 1095774001243 Mg2+ binding site [ion binding]; other site 1095774001244 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1095774001245 synthetase active site [active] 1095774001246 NTP binding site [chemical binding]; other site 1095774001247 metal binding site [ion binding]; metal-binding site 1095774001248 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1095774001249 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1095774001250 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1095774001251 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1095774001252 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1095774001253 catalytic site [active] 1095774001254 G-X2-G-X-G-K; other site 1095774001255 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1095774001256 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1095774001257 nucleotide binding pocket [chemical binding]; other site 1095774001258 K-X-D-G motif; other site 1095774001259 catalytic site [active] 1095774001260 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1095774001261 Predicted membrane protein [Function unknown]; Region: COG2860 1095774001262 UPF0126 domain; Region: UPF0126; pfam03458 1095774001263 UPF0126 domain; Region: UPF0126; pfam03458 1095774001264 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1095774001265 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1095774001266 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1095774001267 putative acyl-acceptor binding pocket; other site 1095774001268 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 1095774001269 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 1095774001270 hypothetical protein; Provisional; Region: PRK11820 1095774001271 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1095774001272 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1095774001273 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 1095774001274 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1095774001275 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1095774001276 Nucleoside recognition; Region: Gate; pfam07670 1095774001277 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1095774001278 ribonuclease PH; Reviewed; Region: rph; PRK00173 1095774001279 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1095774001280 hexamer interface [polypeptide binding]; other site 1095774001281 active site 1095774001282 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1095774001283 active site 1095774001284 division inhibitor protein; Provisional; Region: slmA; PRK09480 1095774001285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1095774001286 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1095774001287 trimer interface [polypeptide binding]; other site 1095774001288 active site 1095774001289 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1095774001290 Flavoprotein; Region: Flavoprotein; pfam02441 1095774001291 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1095774001292 hypothetical protein; Reviewed; Region: PRK00024 1095774001293 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1095774001294 MPN+ (JAMM) motif; other site 1095774001295 Zinc-binding site [ion binding]; other site 1095774001296 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1095774001297 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1095774001298 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1095774001299 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1095774001300 DNA binding site [nucleotide binding] 1095774001301 catalytic residue [active] 1095774001302 H2TH interface [polypeptide binding]; other site 1095774001303 putative catalytic residues [active] 1095774001304 turnover-facilitating residue; other site 1095774001305 intercalation triad [nucleotide binding]; other site 1095774001306 8OG recognition residue [nucleotide binding]; other site 1095774001307 putative reading head residues; other site 1095774001308 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1095774001309 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1095774001310 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1095774001311 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1095774001312 active site 1095774001313 (T/H)XGH motif; other site 1095774001314 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1095774001315 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1095774001316 putative metal binding site; other site 1095774001317 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1095774001318 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1095774001319 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1095774001320 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1095774001321 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1095774001322 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 1095774001323 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1095774001324 putative active site [active] 1095774001325 putative glycosyl transferase; Provisional; Region: PRK10073 1095774001326 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1095774001327 active site 1095774001328 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1095774001329 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1095774001330 putative active site [active] 1095774001331 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1095774001332 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1095774001333 NAD binding site [chemical binding]; other site 1095774001334 homodimer interface [polypeptide binding]; other site 1095774001335 active site 1095774001336 substrate binding site [chemical binding]; other site 1095774001337 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1095774001338 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1095774001339 putative ADP-binding pocket [chemical binding]; other site 1095774001340 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 1095774001341 putative active site [active] 1095774001342 putative catalytic site [active] 1095774001343 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1095774001344 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1095774001345 putative active site [active] 1095774001346 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1095774001347 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1095774001348 O-Antigen ligase; Region: Wzy_C; pfam04932 1095774001349 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1095774001350 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1095774001351 putative active site [active] 1095774001352 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1095774001353 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1095774001354 putative active site [active] 1095774001355 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1095774001356 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1095774001357 NADP binding site [chemical binding]; other site 1095774001358 homopentamer interface [polypeptide binding]; other site 1095774001359 substrate binding site [chemical binding]; other site 1095774001360 active site 1095774001361 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1095774001362 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1095774001363 substrate-cofactor binding pocket; other site 1095774001364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774001365 catalytic residue [active] 1095774001366 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1095774001367 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1095774001368 NAD(P) binding site [chemical binding]; other site 1095774001369 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1095774001370 NodB motif; other site 1095774001371 putative active site [active] 1095774001372 putative catalytic site [active] 1095774001373 Zn binding site [ion binding]; other site 1095774001374 AmiB activator; Provisional; Region: PRK11637 1095774001375 Peptidase family M23; Region: Peptidase_M23; pfam01551 1095774001376 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1095774001377 active site residue [active] 1095774001378 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1095774001379 GSH binding site [chemical binding]; other site 1095774001380 catalytic residues [active] 1095774001381 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1095774001382 SecA binding site; other site 1095774001383 Preprotein binding site; other site 1095774001384 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1095774001385 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1095774001386 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1095774001387 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1095774001388 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1095774001389 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1095774001390 trimer interface [polypeptide binding]; other site 1095774001391 active site 1095774001392 substrate binding site [chemical binding]; other site 1095774001393 CoA binding site [chemical binding]; other site 1095774001394 putative rRNA methylase; Provisional; Region: PRK10358 1095774001395 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1095774001396 HAMP domain; Region: HAMP; pfam00672 1095774001397 dimerization interface [polypeptide binding]; other site 1095774001398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1095774001399 dimer interface [polypeptide binding]; other site 1095774001400 phosphorylation site [posttranslational modification] 1095774001401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774001402 ATP binding site [chemical binding]; other site 1095774001403 Mg2+ binding site [ion binding]; other site 1095774001404 G-X-G motif; other site 1095774001405 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1095774001406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774001407 active site 1095774001408 intermolecular recognition site; other site 1095774001409 dimerization interface [polypeptide binding]; other site 1095774001410 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1095774001411 DNA binding site [nucleotide binding] 1095774001412 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1095774001413 dimer interface [polypeptide binding]; other site 1095774001414 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 1095774001415 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1095774001416 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1095774001417 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1095774001418 active site 1095774001419 ADP/pyrophosphate binding site [chemical binding]; other site 1095774001420 dimerization interface [polypeptide binding]; other site 1095774001421 allosteric effector site; other site 1095774001422 fructose-1,6-bisphosphate binding site; other site 1095774001423 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1095774001424 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774001425 substrate binding pocket [chemical binding]; other site 1095774001426 membrane-bound complex binding site; other site 1095774001427 hinge residues; other site 1095774001428 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 1095774001429 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1095774001430 triosephosphate isomerase; Provisional; Region: PRK14567 1095774001431 substrate binding site [chemical binding]; other site 1095774001432 dimer interface [polypeptide binding]; other site 1095774001433 catalytic triad [active] 1095774001434 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1095774001435 Predicted membrane protein [Function unknown]; Region: COG3152 1095774001436 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1095774001437 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1095774001438 FAD binding pocket [chemical binding]; other site 1095774001439 FAD binding motif [chemical binding]; other site 1095774001440 phosphate binding motif [ion binding]; other site 1095774001441 beta-alpha-beta structure motif; other site 1095774001442 NAD binding pocket [chemical binding]; other site 1095774001443 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 1095774001444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774001445 putative substrate translocation pore; other site 1095774001446 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1095774001447 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1095774001448 putative active site [active] 1095774001449 glycerol kinase; Provisional; Region: glpK; PRK00047 1095774001450 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1095774001451 N- and C-terminal domain interface [polypeptide binding]; other site 1095774001452 active site 1095774001453 MgATP binding site [chemical binding]; other site 1095774001454 catalytic site [active] 1095774001455 metal binding site [ion binding]; metal-binding site 1095774001456 glycerol binding site [chemical binding]; other site 1095774001457 homotetramer interface [polypeptide binding]; other site 1095774001458 homodimer interface [polypeptide binding]; other site 1095774001459 FBP binding site [chemical binding]; other site 1095774001460 protein IIAGlc interface [polypeptide binding]; other site 1095774001461 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1095774001462 amphipathic channel; other site 1095774001463 Asn-Pro-Ala signature motifs; other site 1095774001464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 1095774001465 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1095774001466 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1095774001467 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774001468 Walker A motif; other site 1095774001469 ATP binding site [chemical binding]; other site 1095774001470 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1095774001471 Walker B motif; other site 1095774001472 arginine finger; other site 1095774001473 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1095774001474 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1095774001475 active site 1095774001476 HslU subunit interaction site [polypeptide binding]; other site 1095774001477 cell division protein FtsN; Provisional; Region: PRK12757 1095774001478 Sporulation related domain; Region: SPOR; cl10051 1095774001479 Sporulation related domain; Region: SPOR; cl10051 1095774001480 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774001481 DNA binding site [nucleotide binding] 1095774001482 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1095774001483 domain linker motif; other site 1095774001484 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1095774001485 dimerization interface [polypeptide binding]; other site 1095774001486 ligand binding site [chemical binding]; other site 1095774001487 primosome assembly protein PriA; Validated; Region: PRK05580 1095774001488 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1095774001489 ATP binding site [chemical binding]; other site 1095774001490 putative Mg++ binding site [ion binding]; other site 1095774001491 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1095774001492 ATP-binding site [chemical binding]; other site 1095774001493 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1095774001494 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1095774001495 dimerization interface [polypeptide binding]; other site 1095774001496 DNA binding site [nucleotide binding] 1095774001497 corepressor binding sites; other site 1095774001498 cystathionine gamma-synthase; Provisional; Region: PRK08045 1095774001499 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1095774001500 homodimer interface [polypeptide binding]; other site 1095774001501 substrate-cofactor binding pocket; other site 1095774001502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774001503 catalytic residue [active] 1095774001504 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1095774001505 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1095774001506 putative catalytic residues [active] 1095774001507 putative nucleotide binding site [chemical binding]; other site 1095774001508 putative aspartate binding site [chemical binding]; other site 1095774001509 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1095774001510 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1095774001511 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1095774001512 FAD binding site [chemical binding]; other site 1095774001513 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1095774001514 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774001515 dimerization interface [polypeptide binding]; other site 1095774001516 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1095774001517 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774001518 dimer interface [polypeptide binding]; other site 1095774001519 putative CheW interface [polypeptide binding]; other site 1095774001520 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1095774001521 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1095774001522 acetylornithine deacetylase; Provisional; Region: PRK05111 1095774001523 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1095774001524 metal binding site [ion binding]; metal-binding site 1095774001525 putative dimer interface [polypeptide binding]; other site 1095774001526 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1095774001527 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1095774001528 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1095774001529 nucleotide binding site [chemical binding]; other site 1095774001530 N-acetyl-L-glutamate binding site [chemical binding]; other site 1095774001531 argininosuccinate synthase; Provisional; Region: PRK13820 1095774001532 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1095774001533 ANP binding site [chemical binding]; other site 1095774001534 Substrate Binding Site II [chemical binding]; other site 1095774001535 Substrate Binding Site I [chemical binding]; other site 1095774001536 argininosuccinate lyase; Provisional; Region: PRK04833 1095774001537 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1095774001538 active sites [active] 1095774001539 tetramer interface [polypeptide binding]; other site 1095774001540 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1095774001541 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774001542 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1095774001543 dimerization interface [polypeptide binding]; other site 1095774001544 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1095774001545 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1095774001546 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1095774001547 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1095774001548 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1095774001549 hypothetical protein; Provisional; Region: PRK11056 1095774001550 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1095774001551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774001552 S-adenosylmethionine binding site [chemical binding]; other site 1095774001553 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1095774001554 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1095774001555 N-terminal plug; other site 1095774001556 ligand-binding site [chemical binding]; other site 1095774001557 glutamate racemase; Provisional; Region: PRK00865 1095774001558 transcriptional regulator HdfR; Provisional; Region: PRK03601 1095774001559 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774001560 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1095774001561 dimerization interface [polypeptide binding]; other site 1095774001562 hypothetical protein; Provisional; Region: PRK11027 1095774001563 putative ATP-dependent protease; Provisional; Region: PRK09862 1095774001564 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1095774001565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774001566 Walker A motif; other site 1095774001567 ATP binding site [chemical binding]; other site 1095774001568 Walker B motif; other site 1095774001569 arginine finger; other site 1095774001570 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1095774001571 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1095774001572 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1095774001573 PYR/PP interface [polypeptide binding]; other site 1095774001574 dimer interface [polypeptide binding]; other site 1095774001575 TPP binding site [chemical binding]; other site 1095774001576 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1095774001577 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1095774001578 TPP-binding site [chemical binding]; other site 1095774001579 dimer interface [polypeptide binding]; other site 1095774001580 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1095774001581 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1095774001582 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1095774001583 homodimer interface [polypeptide binding]; other site 1095774001584 substrate-cofactor binding pocket; other site 1095774001585 catalytic residue [active] 1095774001586 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1095774001587 threonine dehydratase; Reviewed; Region: PRK09224 1095774001588 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1095774001589 tetramer interface [polypeptide binding]; other site 1095774001590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774001591 catalytic residue [active] 1095774001592 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1095774001593 putative Ile/Val binding site [chemical binding]; other site 1095774001594 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1095774001595 putative Ile/Val binding site [chemical binding]; other site 1095774001596 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774001597 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1095774001598 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1095774001599 putative dimerization interface [polypeptide binding]; other site 1095774001600 ketol-acid reductoisomerase; Validated; Region: PRK05225 1095774001601 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1095774001602 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1095774001603 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1095774001604 H+ Antiporter protein; Region: 2A0121; TIGR00900 1095774001605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774001606 putative substrate translocation pore; other site 1095774001607 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1095774001608 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1095774001609 classical (c) SDRs; Region: SDR_c; cd05233 1095774001610 NAD(P) binding site [chemical binding]; other site 1095774001611 active site 1095774001612 Biofilm formation and stress response factor; Region: BsmA; pfam10014 1095774001613 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1095774001614 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774001615 substrate binding pocket [chemical binding]; other site 1095774001616 membrane-bound complex binding site; other site 1095774001617 hinge residues; other site 1095774001618 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774001619 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774001620 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1095774001621 putative effector binding pocket; other site 1095774001622 dimerization interface [polypeptide binding]; other site 1095774001623 metabolite-proton symporter; Region: 2A0106; TIGR00883 1095774001624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774001625 putative substrate translocation pore; other site 1095774001626 inner membrane protein YhjD; Region: TIGR00766 1095774001627 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774001628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774001629 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1095774001630 putative effector binding pocket; other site 1095774001631 putative dimerization interface [polypeptide binding]; other site 1095774001632 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1095774001633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1095774001634 NAD(P) binding site [chemical binding]; other site 1095774001635 active site 1095774001636 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1095774001637 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1095774001638 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1095774001639 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1095774001640 putative C-terminal domain interface [polypeptide binding]; other site 1095774001641 putative GSH binding site (G-site) [chemical binding]; other site 1095774001642 putative dimer interface [polypeptide binding]; other site 1095774001643 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1095774001644 putative N-terminal domain interface [polypeptide binding]; other site 1095774001645 putative dimer interface [polypeptide binding]; other site 1095774001646 putative substrate binding pocket (H-site) [chemical binding]; other site 1095774001647 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1095774001648 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774001649 DNA-binding site [nucleotide binding]; DNA binding site 1095774001650 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1095774001651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774001652 homodimer interface [polypeptide binding]; other site 1095774001653 catalytic residue [active] 1095774001654 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1095774001655 malate:quinone oxidoreductase; Validated; Region: PRK05257 1095774001656 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1095774001657 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 1095774001658 hypothetical protein; Provisional; Region: PRK11469 1095774001659 Domain of unknown function DUF; Region: DUF204; pfam02659 1095774001660 Domain of unknown function DUF; Region: DUF204; pfam02659 1095774001661 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1095774001662 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1095774001663 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1095774001664 TAP-like protein; Region: Abhydrolase_4; pfam08386 1095774001665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774001666 D-galactonate transporter; Region: 2A0114; TIGR00893 1095774001667 putative substrate translocation pore; other site 1095774001668 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774001669 DNA-binding site [nucleotide binding]; DNA binding site 1095774001670 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1095774001671 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1095774001672 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1095774001673 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1095774001674 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1095774001675 putative NAD(P) binding site [chemical binding]; other site 1095774001676 catalytic Zn binding site [ion binding]; other site 1095774001677 structural Zn binding site [ion binding]; other site 1095774001678 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 1095774001679 active site 1095774001680 chromosome condensation membrane protein; Provisional; Region: PRK14196 1095774001681 putative hydrolase; Provisional; Region: PRK11460 1095774001682 Predicted esterase [General function prediction only]; Region: COG0400 1095774001683 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1095774001684 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1095774001685 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1095774001686 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1095774001687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774001688 Walker A/P-loop; other site 1095774001689 ATP binding site [chemical binding]; other site 1095774001690 Q-loop/lid; other site 1095774001691 ABC transporter signature motif; other site 1095774001692 Walker B; other site 1095774001693 D-loop; other site 1095774001694 H-loop/switch region; other site 1095774001695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774001696 Coenzyme A binding pocket [chemical binding]; other site 1095774001697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1095774001698 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1095774001699 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1095774001700 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1095774001701 Zn2+ binding site [ion binding]; other site 1095774001702 Mg2+ binding site [ion binding]; other site 1095774001703 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1095774001704 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1095774001705 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1095774001706 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1095774001707 sensor protein KdpD; Provisional; Region: PRK10490 1095774001708 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1095774001709 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1095774001710 Ligand Binding Site [chemical binding]; other site 1095774001711 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1095774001712 GAF domain; Region: GAF_3; pfam13492 1095774001713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1095774001714 dimer interface [polypeptide binding]; other site 1095774001715 phosphorylation site [posttranslational modification] 1095774001716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774001717 ATP binding site [chemical binding]; other site 1095774001718 Mg2+ binding site [ion binding]; other site 1095774001719 G-X-G motif; other site 1095774001720 hypothetical protein; Provisional; Region: PRK05208 1095774001721 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774001722 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774001723 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1095774001724 putative effector binding pocket; other site 1095774001725 dimerization interface [polypeptide binding]; other site 1095774001726 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1095774001727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774001728 putative substrate translocation pore; other site 1095774001729 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1095774001730 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1095774001731 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1095774001732 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1095774001733 nucleophilic elbow; other site 1095774001734 catalytic triad; other site 1095774001735 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1095774001736 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1095774001737 trimer interface [polypeptide binding]; other site 1095774001738 eyelet of channel; other site 1095774001739 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1095774001740 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1095774001741 putative active site [active] 1095774001742 catalytic site [active] 1095774001743 putative metal binding site [ion binding]; other site 1095774001744 hypothetical protein; Provisional; Region: PRK11622 1095774001745 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1095774001746 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1095774001747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774001748 dimer interface [polypeptide binding]; other site 1095774001749 conserved gate region; other site 1095774001750 putative PBP binding loops; other site 1095774001751 ABC-ATPase subunit interface; other site 1095774001752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774001753 conserved gate region; other site 1095774001754 ABC-ATPase subunit interface; other site 1095774001755 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1095774001756 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774001757 Walker A/P-loop; other site 1095774001758 ATP binding site [chemical binding]; other site 1095774001759 Q-loop/lid; other site 1095774001760 ABC transporter signature motif; other site 1095774001761 Walker B; other site 1095774001762 D-loop; other site 1095774001763 H-loop/switch region; other site 1095774001764 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1095774001765 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1095774001766 active site 1095774001767 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1095774001768 MarR family; Region: MarR_2; pfam12802 1095774001769 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1095774001770 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1095774001771 glutathione reductase; Validated; Region: PRK06116 1095774001772 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1095774001773 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1095774001774 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1095774001775 ribonuclease Z; Region: RNase_Z; TIGR02651 1095774001776 CAAX protease self-immunity; Region: Abi; pfam02517 1095774001777 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1095774001778 oligopeptidase A; Provisional; Region: PRK10911 1095774001779 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1095774001780 active site 1095774001781 Zn binding site [ion binding]; other site 1095774001782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774001783 S-adenosylmethionine binding site [chemical binding]; other site 1095774001784 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1095774001785 Ligand Binding Site [chemical binding]; other site 1095774001786 universal stress protein UspB; Provisional; Region: PRK04960 1095774001787 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1095774001788 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1095774001789 Predicted flavoproteins [General function prediction only]; Region: COG2081 1095774001790 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1095774001791 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1095774001792 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1095774001793 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1095774001794 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1095774001795 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1095774001796 Walker A/P-loop; other site 1095774001797 ATP binding site [chemical binding]; other site 1095774001798 Q-loop/lid; other site 1095774001799 ABC transporter signature motif; other site 1095774001800 Walker B; other site 1095774001801 D-loop; other site 1095774001802 H-loop/switch region; other site 1095774001803 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1095774001804 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1095774001805 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1095774001806 Walker A/P-loop; other site 1095774001807 ATP binding site [chemical binding]; other site 1095774001808 Q-loop/lid; other site 1095774001809 ABC transporter signature motif; other site 1095774001810 Walker B; other site 1095774001811 D-loop; other site 1095774001812 H-loop/switch region; other site 1095774001813 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1095774001814 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 1095774001815 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1095774001816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774001817 dimer interface [polypeptide binding]; other site 1095774001818 conserved gate region; other site 1095774001819 putative PBP binding loops; other site 1095774001820 ABC-ATPase subunit interface; other site 1095774001821 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1095774001822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774001823 dimer interface [polypeptide binding]; other site 1095774001824 conserved gate region; other site 1095774001825 putative PBP binding loops; other site 1095774001826 ABC-ATPase subunit interface; other site 1095774001827 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1095774001828 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1095774001829 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 1095774001830 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1095774001831 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1095774001832 Archaeal Glu-tRNAGln amidotransferase subunit E (contains GAD domain) [Translation, ribosomal structure and biogenesis]; Region: GatE; COG2511 1095774001833 short chain dehydrogenase; Provisional; Region: PRK08177 1095774001834 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1095774001835 NAD(P) binding site [chemical binding]; other site 1095774001836 active site 1095774001837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1095774001838 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1095774001839 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774001840 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774001841 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1095774001842 dimer interface [polypeptide binding]; other site 1095774001843 active site 1095774001844 Schiff base residues; other site 1095774001845 proline/glycine betaine transporter; Provisional; Region: PRK10642 1095774001846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774001847 putative substrate translocation pore; other site 1095774001848 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1095774001849 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1095774001850 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1095774001851 mannonate dehydratase; Region: uxuA; TIGR00695 1095774001852 mannonate dehydratase; Provisional; Region: PRK03906 1095774001853 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1095774001854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774001855 DNA-binding site [nucleotide binding]; DNA binding site 1095774001856 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1095774001857 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1095774001858 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1095774001859 xanthine permease; Region: pbuX; TIGR03173 1095774001860 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1095774001861 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1095774001862 tetrameric interface [polypeptide binding]; other site 1095774001863 NAD binding site [chemical binding]; other site 1095774001864 catalytic residues [active] 1095774001865 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1095774001866 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1095774001867 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1095774001868 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1095774001869 putative active site [active] 1095774001870 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1095774001871 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1095774001872 Metal-binding active site; metal-binding site 1095774001873 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1095774001874 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1095774001875 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1095774001876 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1095774001877 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1095774001878 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1095774001879 PYR/PP interface [polypeptide binding]; other site 1095774001880 dimer interface [polypeptide binding]; other site 1095774001881 TPP binding site [chemical binding]; other site 1095774001882 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1095774001883 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1095774001884 TPP-binding site; other site 1095774001885 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1095774001886 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1095774001887 substrate binding site [chemical binding]; other site 1095774001888 ATP binding site [chemical binding]; other site 1095774001889 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 1095774001890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 1095774001891 hypothetical protein; Provisional; Region: PRK11615 1095774001892 hypothetical protein; Provisional; Region: PRK11212 1095774001893 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1095774001894 CPxP motif; other site 1095774001895 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1095774001896 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1095774001897 metal-binding site [ion binding] 1095774001898 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1095774001899 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1095774001900 Predicted membrane protein [Function unknown]; Region: COG3714 1095774001901 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1095774001902 hypothetical protein; Provisional; Region: PRK10910 1095774001903 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1095774001904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774001905 S-adenosylmethionine binding site [chemical binding]; other site 1095774001906 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1095774001907 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1095774001908 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1095774001909 P loop; other site 1095774001910 GTP binding site [chemical binding]; other site 1095774001911 cell division protein FtsE; Provisional; Region: PRK10908 1095774001912 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774001913 Walker A/P-loop; other site 1095774001914 ATP binding site [chemical binding]; other site 1095774001915 Q-loop/lid; other site 1095774001916 ABC transporter signature motif; other site 1095774001917 Walker B; other site 1095774001918 D-loop; other site 1095774001919 H-loop/switch region; other site 1095774001920 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1095774001921 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1095774001922 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1095774001923 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1095774001924 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1095774001925 DNA binding residues [nucleotide binding] 1095774001926 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1095774001927 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1095774001928 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1095774001929 dimerization interface [polypeptide binding]; other site 1095774001930 ligand binding site [chemical binding]; other site 1095774001931 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1095774001932 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1095774001933 TM-ABC transporter signature motif; other site 1095774001934 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1095774001935 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1095774001936 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1095774001937 TM-ABC transporter signature motif; other site 1095774001938 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1095774001939 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1095774001940 Walker A/P-loop; other site 1095774001941 ATP binding site [chemical binding]; other site 1095774001942 Q-loop/lid; other site 1095774001943 ABC transporter signature motif; other site 1095774001944 Walker B; other site 1095774001945 D-loop; other site 1095774001946 H-loop/switch region; other site 1095774001947 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1095774001948 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1095774001949 Walker A/P-loop; other site 1095774001950 ATP binding site [chemical binding]; other site 1095774001951 Q-loop/lid; other site 1095774001952 ABC transporter signature motif; other site 1095774001953 Walker B; other site 1095774001954 D-loop; other site 1095774001955 H-loop/switch region; other site 1095774001956 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1095774001957 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 1095774001958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774001959 dimer interface [polypeptide binding]; other site 1095774001960 conserved gate region; other site 1095774001961 putative PBP binding loops; other site 1095774001962 ABC-ATPase subunit interface; other site 1095774001963 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1095774001964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774001965 dimer interface [polypeptide binding]; other site 1095774001966 conserved gate region; other site 1095774001967 putative PBP binding loops; other site 1095774001968 ABC-ATPase subunit interface; other site 1095774001969 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1095774001970 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1095774001971 Walker A/P-loop; other site 1095774001972 ATP binding site [chemical binding]; other site 1095774001973 Q-loop/lid; other site 1095774001974 ABC transporter signature motif; other site 1095774001975 Walker B; other site 1095774001976 D-loop; other site 1095774001977 H-loop/switch region; other site 1095774001978 TOBE domain; Region: TOBE_2; pfam08402 1095774001979 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1095774001980 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1095774001981 putative active site [active] 1095774001982 catalytic site [active] 1095774001983 putative metal binding site [ion binding]; other site 1095774001984 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 1095774001985 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1095774001986 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1095774001987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774001988 Coenzyme A binding pocket [chemical binding]; other site 1095774001989 Pirin-related protein [General function prediction only]; Region: COG1741 1095774001990 Pirin; Region: Pirin; pfam02678 1095774001991 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1095774001992 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774001993 DNA binding site [nucleotide binding] 1095774001994 domain linker motif; other site 1095774001995 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1095774001996 putative ligand binding site [chemical binding]; other site 1095774001997 putative dimerization interface [polypeptide binding]; other site 1095774001998 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1095774001999 ATP-binding site [chemical binding]; other site 1095774002000 Gluconate-6-phosphate binding site [chemical binding]; other site 1095774002001 Shikimate kinase; Region: SKI; pfam01202 1095774002002 low affinity gluconate transporter; Provisional; Region: PRK10472 1095774002003 gluconate transporter; Region: gntP; TIGR00791 1095774002004 putative antibiotic transporter; Provisional; Region: PRK10739 1095774002005 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1095774002006 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1095774002007 glycogen branching enzyme; Provisional; Region: PRK05402 1095774002008 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1095774002009 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1095774002010 active site 1095774002011 catalytic site [active] 1095774002012 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1095774002013 glycogen debranching enzyme; Provisional; Region: PRK03705 1095774002014 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1095774002015 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1095774002016 active site 1095774002017 catalytic site [active] 1095774002018 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1095774002019 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1095774002020 ligand binding site; other site 1095774002021 oligomer interface; other site 1095774002022 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1095774002023 dimer interface [polypeptide binding]; other site 1095774002024 N-terminal domain interface [polypeptide binding]; other site 1095774002025 sulfate 1 binding site; other site 1095774002026 glycogen synthase; Provisional; Region: glgA; PRK00654 1095774002027 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1095774002028 ADP-binding pocket [chemical binding]; other site 1095774002029 homodimer interface [polypeptide binding]; other site 1095774002030 glycogen phosphorylase; Provisional; Region: PRK14986 1095774002031 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1095774002032 homodimer interface [polypeptide binding]; other site 1095774002033 active site pocket [active] 1095774002034 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1095774002035 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1095774002036 active site residue [active] 1095774002037 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1095774002038 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1095774002039 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1095774002040 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1095774002041 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1095774002042 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1095774002043 maltodextrin phosphorylase; Provisional; Region: PRK14985 1095774002044 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1095774002045 homodimer interface [polypeptide binding]; other site 1095774002046 active site pocket [active] 1095774002047 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1095774002048 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1095774002049 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1095774002050 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1095774002051 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1095774002052 DNA utilization protein GntX; Provisional; Region: PRK11595 1095774002053 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1095774002054 active site 1095774002055 carboxylesterase BioH; Provisional; Region: PRK10349 1095774002056 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1095774002057 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1095774002058 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 1095774002059 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 1095774002060 active site 1095774002061 homodimer interface [polypeptide binding]; other site 1095774002062 catalytic site [active] 1095774002063 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1095774002064 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1095774002065 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1095774002066 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1095774002067 RNA binding site [nucleotide binding]; other site 1095774002068 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1095774002069 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1095774002070 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1095774002071 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1095774002072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774002073 active site 1095774002074 phosphorylation site [posttranslational modification] 1095774002075 intermolecular recognition site; other site 1095774002076 dimerization interface [polypeptide binding]; other site 1095774002077 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1095774002078 DNA binding site [nucleotide binding] 1095774002079 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1095774002080 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774002081 dimerization interface [polypeptide binding]; other site 1095774002082 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1095774002083 dimer interface [polypeptide binding]; other site 1095774002084 phosphorylation site [posttranslational modification] 1095774002085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774002086 ATP binding site [chemical binding]; other site 1095774002087 Mg2+ binding site [ion binding]; other site 1095774002088 G-X-G motif; other site 1095774002089 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1095774002090 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1095774002091 active site 1095774002092 substrate-binding site [chemical binding]; other site 1095774002093 metal-binding site [ion binding] 1095774002094 ATP binding site [chemical binding]; other site 1095774002095 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1095774002096 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1095774002097 dimerization interface [polypeptide binding]; other site 1095774002098 domain crossover interface; other site 1095774002099 redox-dependent activation switch; other site 1095774002100 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1095774002101 RNA binding surface [nucleotide binding]; other site 1095774002102 GMP/IMP nucleotidase; Provisional; Region: PRK14988 1095774002103 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1095774002104 motif II; other site 1095774002105 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1095774002106 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1095774002107 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1095774002108 ADP-ribose binding site [chemical binding]; other site 1095774002109 dimer interface [polypeptide binding]; other site 1095774002110 active site 1095774002111 nudix motif; other site 1095774002112 metal binding site [ion binding]; metal-binding site 1095774002113 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1095774002114 Transglycosylase; Region: Transgly; pfam00912 1095774002115 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1095774002116 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1095774002117 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1095774002118 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 1095774002119 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 1095774002120 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1095774002121 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1095774002122 shikimate kinase; Reviewed; Region: aroK; PRK00131 1095774002123 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1095774002124 ADP binding site [chemical binding]; other site 1095774002125 magnesium binding site [ion binding]; other site 1095774002126 putative shikimate binding site; other site 1095774002127 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1095774002128 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1095774002129 active site 1095774002130 dimer interface [polypeptide binding]; other site 1095774002131 metal binding site [ion binding]; metal-binding site 1095774002132 hypothetical protein; Reviewed; Region: PRK11901 1095774002133 cell division protein DamX; Validated; Region: PRK10905 1095774002134 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1095774002135 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1095774002136 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1095774002137 substrate binding site [chemical binding]; other site 1095774002138 hexamer interface [polypeptide binding]; other site 1095774002139 metal binding site [ion binding]; metal-binding site 1095774002140 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1095774002141 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1095774002142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774002143 motif II; other site 1095774002144 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1095774002145 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1095774002146 active site 1095774002147 HIGH motif; other site 1095774002148 dimer interface [polypeptide binding]; other site 1095774002149 KMSKS motif; other site 1095774002150 cytosine deaminase; Provisional; Region: PRK09230 1095774002151 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1095774002152 active site 1095774002153 putative transporter; Provisional; Region: PRK03699 1095774002154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774002155 putative substrate translocation pore; other site 1095774002156 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1095774002157 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1095774002158 substrate binding site [chemical binding]; other site 1095774002159 hypothetical protein; Provisional; Region: PRK10204 1095774002160 cell filamentation protein Fic; Provisional; Region: PRK10347 1095774002161 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1095774002162 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1095774002163 glutamine binding [chemical binding]; other site 1095774002164 catalytic triad [active] 1095774002165 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1095774002166 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1095774002167 inhibitor-cofactor binding pocket; inhibition site 1095774002168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774002169 catalytic residue [active] 1095774002170 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1095774002171 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1095774002172 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1095774002173 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1095774002174 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1095774002175 ligand binding site [chemical binding]; other site 1095774002176 flexible hinge region; other site 1095774002177 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1095774002178 putative switch regulator; other site 1095774002179 non-specific DNA interactions [nucleotide binding]; other site 1095774002180 DNA binding site [nucleotide binding] 1095774002181 sequence specific DNA binding site [nucleotide binding]; other site 1095774002182 putative cAMP binding site [chemical binding]; other site 1095774002183 hypothetical protein; Provisional; Region: PRK10738 1095774002184 phosphoribulokinase; Provisional; Region: PRK15453 1095774002185 active site 1095774002186 hypothetical protein; Provisional; Region: PRK04966 1095774002187 putative hydrolase; Provisional; Region: PRK10985 1095774002188 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1095774002189 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1095774002190 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774002191 DNA binding site [nucleotide binding] 1095774002192 domain linker motif; other site 1095774002193 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1095774002194 dimerization interface [polypeptide binding]; other site 1095774002195 ligand binding site [chemical binding]; other site 1095774002196 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1095774002197 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774002198 substrate binding pocket [chemical binding]; other site 1095774002199 membrane-bound complex binding site; other site 1095774002200 hinge residues; other site 1095774002201 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 1095774002202 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1095774002203 Walker A/P-loop; other site 1095774002204 ATP binding site [chemical binding]; other site 1095774002205 Q-loop/lid; other site 1095774002206 ABC transporter signature motif; other site 1095774002207 Walker B; other site 1095774002208 D-loop; other site 1095774002209 H-loop/switch region; other site 1095774002210 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1095774002211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774002212 dimer interface [polypeptide binding]; other site 1095774002213 conserved gate region; other site 1095774002214 putative PBP binding loops; other site 1095774002215 ABC-ATPase subunit interface; other site 1095774002216 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1095774002217 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 1095774002218 active site 1095774002219 iron coordination sites [ion binding]; other site 1095774002220 substrate binding pocket [chemical binding]; other site 1095774002221 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1095774002222 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774002223 Walker A/P-loop; other site 1095774002224 ATP binding site [chemical binding]; other site 1095774002225 Q-loop/lid; other site 1095774002226 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1095774002227 ABC transporter; Region: ABC_tran_2; pfam12848 1095774002228 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1095774002229 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1095774002230 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1095774002231 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1095774002232 TrkA-N domain; Region: TrkA_N; pfam02254 1095774002233 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 1095774002234 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 1095774002235 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1095774002236 phi X174 lysis protein; Provisional; Region: PRK02793 1095774002237 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 1095774002238 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1095774002239 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1095774002240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1095774002241 YheO-like PAS domain; Region: PAS_6; pfam08348 1095774002242 HTH domain; Region: HTH_22; pfam13309 1095774002243 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1095774002244 sulfur relay protein TusC; Validated; Region: PRK00211 1095774002245 DsrH like protein; Region: DsrH; cl17347 1095774002246 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1095774002247 S17 interaction site [polypeptide binding]; other site 1095774002248 S8 interaction site; other site 1095774002249 16S rRNA interaction site [nucleotide binding]; other site 1095774002250 streptomycin interaction site [chemical binding]; other site 1095774002251 23S rRNA interaction site [nucleotide binding]; other site 1095774002252 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1095774002253 30S ribosomal protein S7; Validated; Region: PRK05302 1095774002254 elongation factor G; Reviewed; Region: PRK00007 1095774002255 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1095774002256 G1 box; other site 1095774002257 putative GEF interaction site [polypeptide binding]; other site 1095774002258 GTP/Mg2+ binding site [chemical binding]; other site 1095774002259 Switch I region; other site 1095774002260 G2 box; other site 1095774002261 G3 box; other site 1095774002262 Switch II region; other site 1095774002263 G4 box; other site 1095774002264 G5 box; other site 1095774002265 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1095774002266 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1095774002267 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1095774002268 elongation factor Tu; Reviewed; Region: PRK00049 1095774002269 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1095774002270 G1 box; other site 1095774002271 GEF interaction site [polypeptide binding]; other site 1095774002272 GTP/Mg2+ binding site [chemical binding]; other site 1095774002273 Switch I region; other site 1095774002274 G2 box; other site 1095774002275 G3 box; other site 1095774002276 Switch II region; other site 1095774002277 G4 box; other site 1095774002278 G5 box; other site 1095774002279 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1095774002280 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1095774002281 Antibiotic Binding Site [chemical binding]; other site 1095774002282 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 1095774002283 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1095774002284 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1095774002285 heme binding site [chemical binding]; other site 1095774002286 ferroxidase pore; other site 1095774002287 ferroxidase diiron center [ion binding]; other site 1095774002288 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1095774002289 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1095774002290 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1095774002291 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1095774002292 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1095774002293 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1095774002294 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1095774002295 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1095774002296 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1095774002297 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1095774002298 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1095774002299 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1095774002300 protein-rRNA interface [nucleotide binding]; other site 1095774002301 putative translocon binding site; other site 1095774002302 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1095774002303 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1095774002304 G-X-X-G motif; other site 1095774002305 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1095774002306 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1095774002307 23S rRNA interface [nucleotide binding]; other site 1095774002308 5S rRNA interface [nucleotide binding]; other site 1095774002309 putative antibiotic binding site [chemical binding]; other site 1095774002310 L25 interface [polypeptide binding]; other site 1095774002311 L27 interface [polypeptide binding]; other site 1095774002312 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1095774002313 23S rRNA interface [nucleotide binding]; other site 1095774002314 putative translocon interaction site; other site 1095774002315 signal recognition particle (SRP54) interaction site; other site 1095774002316 L23 interface [polypeptide binding]; other site 1095774002317 trigger factor interaction site; other site 1095774002318 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1095774002319 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1095774002320 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1095774002321 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1095774002322 RNA binding site [nucleotide binding]; other site 1095774002323 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1095774002324 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1095774002325 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1095774002326 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1095774002327 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1095774002328 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1095774002329 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1095774002330 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1095774002331 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1095774002332 23S rRNA interface [nucleotide binding]; other site 1095774002333 5S rRNA interface [nucleotide binding]; other site 1095774002334 L27 interface [polypeptide binding]; other site 1095774002335 L5 interface [polypeptide binding]; other site 1095774002336 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1095774002337 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1095774002338 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1095774002339 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1095774002340 23S rRNA binding site [nucleotide binding]; other site 1095774002341 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1095774002342 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1095774002343 SecY translocase; Region: SecY; pfam00344 1095774002344 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1095774002345 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1095774002346 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1095774002347 30S ribosomal protein S11; Validated; Region: PRK05309 1095774002348 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1095774002349 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1095774002350 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1095774002351 RNA binding surface [nucleotide binding]; other site 1095774002352 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1095774002353 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1095774002354 alphaNTD homodimer interface [polypeptide binding]; other site 1095774002355 alphaNTD - beta interaction site [polypeptide binding]; other site 1095774002356 alphaNTD - beta' interaction site [polypeptide binding]; other site 1095774002357 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1095774002358 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1095774002359 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 1095774002360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 1095774002361 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1095774002362 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1095774002363 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1095774002364 TrkA-N domain; Region: TrkA_N; pfam02254 1095774002365 TrkA-C domain; Region: TrkA_C; pfam02080 1095774002366 TrkA-N domain; Region: TrkA_N; pfam02254 1095774002367 TrkA-C domain; Region: TrkA_C; pfam02080 1095774002368 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1095774002369 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1095774002370 putative RNA binding site [nucleotide binding]; other site 1095774002371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774002372 S-adenosylmethionine binding site [chemical binding]; other site 1095774002373 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1095774002374 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1095774002375 putative active site [active] 1095774002376 substrate binding site [chemical binding]; other site 1095774002377 putative cosubstrate binding site; other site 1095774002378 catalytic site [active] 1095774002379 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1095774002380 substrate binding site [chemical binding]; other site 1095774002381 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1095774002382 active site 1095774002383 catalytic residues [active] 1095774002384 metal binding site [ion binding]; metal-binding site 1095774002385 hypothetical protein; Provisional; Region: PRK10736 1095774002386 DNA protecting protein DprA; Region: dprA; TIGR00732 1095774002387 hypothetical protein; Validated; Region: PRK03430 1095774002388 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1095774002389 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1095774002390 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1095774002391 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1095774002392 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1095774002393 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1095774002394 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1095774002395 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1095774002396 shikimate binding site; other site 1095774002397 NAD(P) binding site [chemical binding]; other site 1095774002398 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1095774002399 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1095774002400 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1095774002401 trimer interface [polypeptide binding]; other site 1095774002402 putative metal binding site [ion binding]; other site 1095774002403 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1095774002404 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1095774002405 Walker A/P-loop; other site 1095774002406 ATP binding site [chemical binding]; other site 1095774002407 Q-loop/lid; other site 1095774002408 ABC transporter signature motif; other site 1095774002409 Walker B; other site 1095774002410 D-loop; other site 1095774002411 H-loop/switch region; other site 1095774002412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774002413 dimer interface [polypeptide binding]; other site 1095774002414 conserved gate region; other site 1095774002415 putative PBP binding loops; other site 1095774002416 ABC-ATPase subunit interface; other site 1095774002417 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1095774002418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774002419 conserved gate region; other site 1095774002420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774002421 ABC-ATPase subunit interface; other site 1095774002422 putative PBP binding loops; other site 1095774002423 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774002424 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1095774002425 substrate binding pocket [chemical binding]; other site 1095774002426 membrane-bound complex binding site; other site 1095774002427 hinge residues; other site 1095774002428 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1095774002429 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1095774002430 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 1095774002431 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1095774002432 FMN binding site [chemical binding]; other site 1095774002433 active site 1095774002434 catalytic residues [active] 1095774002435 substrate binding site [chemical binding]; other site 1095774002436 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1095774002437 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1095774002438 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1095774002439 Na binding site [ion binding]; other site 1095774002440 hypothetical protein; Provisional; Region: PRK10633 1095774002441 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1095774002442 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1095774002443 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1095774002444 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1095774002445 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1095774002446 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1095774002447 carboxyltransferase (CT) interaction site; other site 1095774002448 biotinylation site [posttranslational modification]; other site 1095774002449 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1095774002450 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1095774002451 active site 1095774002452 trimer interface [polypeptide binding]; other site 1095774002453 dimer interface [polypeptide binding]; other site 1095774002454 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1095774002455 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1095774002456 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1095774002457 Moco binding site; other site 1095774002458 metal coordination site [ion binding]; other site 1095774002459 regulatory protein CsrD; Provisional; Region: PRK11059 1095774002460 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1095774002461 active site 1095774002462 I-site; other site 1095774002463 metal binding site [ion binding]; metal-binding site 1095774002464 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1095774002465 rod shape-determining protein MreB; Provisional; Region: PRK13927 1095774002466 MreB and similar proteins; Region: MreB_like; cd10225 1095774002467 nucleotide binding site [chemical binding]; other site 1095774002468 Mg binding site [ion binding]; other site 1095774002469 putative protofilament interaction site [polypeptide binding]; other site 1095774002470 RodZ interaction site [polypeptide binding]; other site 1095774002471 rod shape-determining protein MreC; Region: mreC; TIGR00219 1095774002472 rod shape-determining protein MreC; Region: MreC; pfam04085 1095774002473 rod shape-determining protein MreD; Provisional; Region: PRK11060 1095774002474 Maf-like protein; Region: Maf; pfam02545 1095774002475 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1095774002476 active site 1095774002477 dimer interface [polypeptide binding]; other site 1095774002478 ribonuclease G; Provisional; Region: PRK11712 1095774002479 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1095774002480 homodimer interface [polypeptide binding]; other site 1095774002481 oligonucleotide binding site [chemical binding]; other site 1095774002482 hypothetical protein; Provisional; Region: PRK10899 1095774002483 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1095774002484 protease TldD; Provisional; Region: tldD; PRK10735 1095774002485 transcriptional regulator; Provisional; Region: PRK10632 1095774002486 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774002487 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1095774002488 putative effector binding pocket; other site 1095774002489 dimerization interface [polypeptide binding]; other site 1095774002490 efflux system membrane protein; Provisional; Region: PRK11594 1095774002491 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1095774002492 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1095774002493 HlyD family secretion protein; Region: HlyD_3; pfam13437 1095774002494 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 1095774002495 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1095774002496 succinic semialdehyde dehydrogenase; Region: PLN02278 1095774002497 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1095774002498 tetramerization interface [polypeptide binding]; other site 1095774002499 NAD(P) binding site [chemical binding]; other site 1095774002500 catalytic residues [active] 1095774002501 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 1095774002502 RNAase interaction site [polypeptide binding]; other site 1095774002503 putative transposase; Provisional; Region: PRK09857 1095774002504 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1095774002505 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1095774002506 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1095774002507 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1095774002508 arginine repressor; Provisional; Region: PRK05066 1095774002509 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1095774002510 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1095774002511 malate dehydrogenase; Provisional; Region: PRK05086 1095774002512 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1095774002513 NAD binding site [chemical binding]; other site 1095774002514 dimerization interface [polypeptide binding]; other site 1095774002515 Substrate binding site [chemical binding]; other site 1095774002516 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1095774002517 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1095774002518 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1095774002519 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1095774002520 GTPase RsgA; Reviewed; Region: PRK12288 1095774002521 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1095774002522 RNA binding site [nucleotide binding]; other site 1095774002523 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1095774002524 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1095774002525 GTP/Mg2+ binding site [chemical binding]; other site 1095774002526 G4 box; other site 1095774002527 G5 box; other site 1095774002528 G1 box; other site 1095774002529 Switch I region; other site 1095774002530 G2 box; other site 1095774002531 G3 box; other site 1095774002532 Switch II region; other site 1095774002533 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1095774002534 catalytic site [active] 1095774002535 putative active site [active] 1095774002536 putative substrate binding site [chemical binding]; other site 1095774002537 dimer interface [polypeptide binding]; other site 1095774002538 epoxyqueuosine reductase; Region: TIGR00276 1095774002539 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1095774002540 putative carbohydrate kinase; Provisional; Region: PRK10565 1095774002541 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1095774002542 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1095774002543 putative substrate binding site [chemical binding]; other site 1095774002544 putative ATP binding site [chemical binding]; other site 1095774002545 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1095774002546 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1095774002547 AMIN domain; Region: AMIN; pfam11741 1095774002548 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1095774002549 active site 1095774002550 metal binding site [ion binding]; metal-binding site 1095774002551 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1095774002552 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1095774002553 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1095774002554 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1095774002555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774002556 ATP binding site [chemical binding]; other site 1095774002557 Mg2+ binding site [ion binding]; other site 1095774002558 G-X-G motif; other site 1095774002559 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1095774002560 ATP binding site [chemical binding]; other site 1095774002561 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1095774002562 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1095774002563 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1095774002564 bacterial Hfq-like; Region: Hfq; cd01716 1095774002565 hexamer interface [polypeptide binding]; other site 1095774002566 Sm1 motif; other site 1095774002567 RNA binding site [nucleotide binding]; other site 1095774002568 Sm2 motif; other site 1095774002569 GTPase HflX; Provisional; Region: PRK11058 1095774002570 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1095774002571 HflX GTPase family; Region: HflX; cd01878 1095774002572 G1 box; other site 1095774002573 GTP/Mg2+ binding site [chemical binding]; other site 1095774002574 Switch I region; other site 1095774002575 G2 box; other site 1095774002576 G3 box; other site 1095774002577 Switch II region; other site 1095774002578 G4 box; other site 1095774002579 G5 box; other site 1095774002580 FtsH protease regulator HflK; Provisional; Region: PRK10930 1095774002581 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1095774002582 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1095774002583 FtsH protease regulator HflC; Provisional; Region: PRK11029 1095774002584 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1095774002585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1095774002586 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1095774002587 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1095774002588 GDP-binding site [chemical binding]; other site 1095774002589 ACT binding site; other site 1095774002590 IMP binding site; other site 1095774002591 transcriptional repressor NsrR; Provisional; Region: PRK11014 1095774002592 Rrf2 family protein; Region: rrf2_super; TIGR00738 1095774002593 exoribonuclease R; Provisional; Region: PRK11642 1095774002594 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1095774002595 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1095774002596 RNB domain; Region: RNB; pfam00773 1095774002597 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1095774002598 RNA binding site [nucleotide binding]; other site 1095774002599 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1095774002600 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1095774002601 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1095774002602 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1095774002603 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1095774002604 active site 1095774002605 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 1095774002606 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774002607 dimerization interface [polypeptide binding]; other site 1095774002608 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1095774002609 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774002610 dimer interface [polypeptide binding]; other site 1095774002611 putative CheW interface [polypeptide binding]; other site 1095774002612 esterase; Provisional; Region: PRK10566 1095774002613 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1095774002614 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1095774002615 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1095774002616 dimer interface [polypeptide binding]; other site 1095774002617 ssDNA binding site [nucleotide binding]; other site 1095774002618 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1095774002619 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1095774002620 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1095774002621 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1095774002622 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1095774002623 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 1095774002624 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1095774002625 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1095774002626 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1095774002627 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1095774002628 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1095774002629 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1095774002630 active site 1095774002631 metal binding site [ion binding]; metal-binding site 1095774002632 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1095774002633 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1095774002634 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1095774002635 active site 1095774002636 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 1095774002637 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1095774002638 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1095774002639 Domain of unknown function DUF21; Region: DUF21; pfam01595 1095774002640 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1095774002641 Transporter associated domain; Region: CorC_HlyC; smart01091 1095774002642 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1095774002643 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1095774002644 Surface antigen; Region: Bac_surface_Ag; pfam01103 1095774002645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1095774002646 Family of unknown function (DUF490); Region: DUF490; pfam04357 1095774002647 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1095774002648 putative active site pocket [active] 1095774002649 dimerization interface [polypeptide binding]; other site 1095774002650 putative catalytic residue [active] 1095774002651 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1095774002652 dimer interface [polypeptide binding]; other site 1095774002653 substrate binding site [chemical binding]; other site 1095774002654 metal binding sites [ion binding]; metal-binding site 1095774002655 Predicted membrane protein [Function unknown]; Region: COG2707 1095774002656 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1095774002657 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1095774002658 dimer interface [polypeptide binding]; other site 1095774002659 ligand binding site [chemical binding]; other site 1095774002660 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774002661 dimerization interface [polypeptide binding]; other site 1095774002662 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1095774002663 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774002664 dimer interface [polypeptide binding]; other site 1095774002665 putative CheW interface [polypeptide binding]; other site 1095774002666 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1095774002667 AMP binding site [chemical binding]; other site 1095774002668 metal binding site [ion binding]; metal-binding site 1095774002669 active site 1095774002670 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1095774002671 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1095774002672 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1095774002673 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1095774002674 hypothetical protein; Provisional; Region: PRK05255 1095774002675 peptidase PmbA; Provisional; Region: PRK11040 1095774002676 Cytochrome b562; Region: Cytochrom_B562; cl01546 1095774002677 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1095774002678 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1095774002679 putative DNA binding site [nucleotide binding]; other site 1095774002680 putative Zn2+ binding site [ion binding]; other site 1095774002681 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1095774002682 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1095774002683 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 1095774002684 substrate binding site [chemical binding]; other site 1095774002685 ATP binding site [chemical binding]; other site 1095774002686 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 1095774002687 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1095774002688 Class I aldolases; Region: Aldolase_Class_I; cl17187 1095774002689 catalytic residue [active] 1095774002690 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1095774002691 dimerization interface [polypeptide binding]; other site 1095774002692 putative active cleft [active] 1095774002693 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1095774002694 active site 1095774002695 catalytic residues [active] 1095774002696 alpha-glucosidase; Provisional; Region: PRK10426 1095774002697 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1095774002698 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 1095774002699 putative active site [active] 1095774002700 putative catalytic site [active] 1095774002701 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1095774002702 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1095774002703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774002704 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1095774002705 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1095774002706 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1095774002707 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 1095774002708 Domain of unknown function (DUF4312); Region: DUF4312; pfam14189 1095774002709 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 1095774002710 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 1095774002711 dihydroorotase; Provisional; Region: PRK09237 1095774002712 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 1095774002713 active site 1095774002714 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 1095774002715 catalytic residue [active] 1095774002716 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 1095774002717 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1095774002718 HTH domain; Region: HTH_11; pfam08279 1095774002719 Mga helix-turn-helix domain; Region: Mga; pfam05043 1095774002720 PRD domain; Region: PRD; pfam00874 1095774002721 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1095774002722 active site 1095774002723 P-loop; other site 1095774002724 phosphorylation site [posttranslational modification] 1095774002725 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1095774002726 active site 1095774002727 phosphorylation site [posttranslational modification] 1095774002728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774002729 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1095774002730 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1095774002731 dimerization interface [polypeptide binding]; other site 1095774002732 Pirin-related protein [General function prediction only]; Region: COG1741 1095774002733 Pirin; Region: Pirin; pfam02678 1095774002734 outer membrane lipoprotein; Provisional; Region: PRK11023 1095774002735 BON domain; Region: BON; pfam04972 1095774002736 BON domain; Region: BON; pfam04972 1095774002737 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1095774002738 dimer interface [polypeptide binding]; other site 1095774002739 active site 1095774002740 hypothetical protein; Reviewed; Region: PRK12497 1095774002741 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 1095774002742 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1095774002743 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1095774002744 putative ligand binding site [chemical binding]; other site 1095774002745 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1095774002746 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1095774002747 putative SAM binding site [chemical binding]; other site 1095774002748 putative homodimer interface [polypeptide binding]; other site 1095774002749 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1095774002750 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1095774002751 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1095774002752 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1095774002753 tetramer interface [polypeptide binding]; other site 1095774002754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774002755 catalytic residue [active] 1095774002756 threonine/serine transporter TdcC; Provisional; Region: PRK13629 1095774002757 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1095774002758 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1095774002759 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1095774002760 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1095774002761 putative dimer interface [polypeptide binding]; other site 1095774002762 N-terminal domain interface [polypeptide binding]; other site 1095774002763 putative substrate binding pocket (H-site) [chemical binding]; other site 1095774002764 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 1095774002765 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1095774002766 active site 1095774002767 substrate binding site [chemical binding]; other site 1095774002768 cosubstrate binding site; other site 1095774002769 catalytic site [active] 1095774002770 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1095774002771 active site 1095774002772 hexamer interface [polypeptide binding]; other site 1095774002773 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1095774002774 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1095774002775 Predicted membrane protein [Function unknown]; Region: COG2259 1095774002776 YqjK-like protein; Region: YqjK; pfam13997 1095774002777 Predicted membrane protein [Function unknown]; Region: COG5393 1095774002778 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1095774002779 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1095774002780 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 1095774002781 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1095774002782 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1095774002783 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 1095774002784 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774002785 DNA-binding site [nucleotide binding]; DNA binding site 1095774002786 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1095774002787 D-galactonate transporter; Region: 2A0114; TIGR00893 1095774002788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774002789 putative substrate translocation pore; other site 1095774002790 Glucuronate isomerase; Region: UxaC; pfam02614 1095774002791 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1095774002792 altronate oxidoreductase; Provisional; Region: PRK03643 1095774002793 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1095774002794 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1095774002795 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1095774002796 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1095774002797 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1095774002798 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1095774002799 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1095774002800 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1095774002801 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 1095774002802 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1095774002803 Cl- selectivity filter; other site 1095774002804 Cl- binding residues [ion binding]; other site 1095774002805 pore gating glutamate residue; other site 1095774002806 dimer interface [polypeptide binding]; other site 1095774002807 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1095774002808 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1095774002809 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1095774002810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774002811 S-adenosylmethionine binding site [chemical binding]; other site 1095774002812 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1095774002813 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1095774002814 active site 1095774002815 FMN binding site [chemical binding]; other site 1095774002816 2,4-decadienoyl-CoA binding site; other site 1095774002817 catalytic residue [active] 1095774002818 4Fe-4S cluster binding site [ion binding]; other site 1095774002819 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1095774002820 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1095774002821 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1095774002822 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774002823 active site 1095774002824 motif I; other site 1095774002825 motif II; other site 1095774002826 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1095774002827 active site clefts [active] 1095774002828 zinc binding site [ion binding]; other site 1095774002829 dimer interface [polypeptide binding]; other site 1095774002830 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1095774002831 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1095774002832 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1095774002833 MASE1; Region: MASE1; cl17823 1095774002834 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1095774002835 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1095774002836 metal binding site [ion binding]; metal-binding site 1095774002837 active site 1095774002838 I-site; other site 1095774002839 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1095774002840 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1095774002841 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1095774002842 anti-RssB factor; Provisional; Region: PRK10244 1095774002843 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1095774002844 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1095774002845 metal binding site [ion binding]; metal-binding site 1095774002846 active site 1095774002847 I-site; other site 1095774002848 GAF domain; Region: GAF; pfam01590 1095774002849 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1095774002850 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1095774002851 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1095774002852 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1095774002853 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774002854 dimer interface [polypeptide binding]; other site 1095774002855 putative CheW interface [polypeptide binding]; other site 1095774002856 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1095774002857 GAF domain; Region: GAF; pfam01590 1095774002858 PAS domain S-box; Region: sensory_box; TIGR00229 1095774002859 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1095774002860 putative active site [active] 1095774002861 heme pocket [chemical binding]; other site 1095774002862 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1095774002863 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1095774002864 metal binding site [ion binding]; metal-binding site 1095774002865 active site 1095774002866 I-site; other site 1095774002867 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1095774002868 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1095774002869 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1095774002870 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774002871 dimerization interface [polypeptide binding]; other site 1095774002872 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1095774002873 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774002874 dimer interface [polypeptide binding]; other site 1095774002875 putative CheW interface [polypeptide binding]; other site 1095774002876 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1095774002877 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774002878 dimer interface [polypeptide binding]; other site 1095774002879 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1095774002880 putative CheW interface [polypeptide binding]; other site 1095774002881 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1095774002882 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1095774002883 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1095774002884 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1095774002885 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1095774002886 HTH domain; Region: HTH_11; pfam08279 1095774002887 PRD domain; Region: PRD; pfam00874 1095774002888 PRD domain; Region: PRD; pfam00874 1095774002889 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1095774002890 active site 1095774002891 P-loop; other site 1095774002892 phosphorylation site [posttranslational modification] 1095774002893 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1095774002894 active site 1095774002895 phosphorylation site [posttranslational modification] 1095774002896 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1095774002897 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1095774002898 active site 1095774002899 P-loop; other site 1095774002900 phosphorylation site [posttranslational modification] 1095774002901 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1095774002902 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1095774002903 intersubunit interface [polypeptide binding]; other site 1095774002904 active site 1095774002905 zinc binding site [ion binding]; other site 1095774002906 Na+ binding site [ion binding]; other site 1095774002907 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1095774002908 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 1095774002909 DksA-like zinc finger domain containing protein; Region: PHA00080 1095774002910 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 1095774002911 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1095774002912 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1095774002913 catalytic residues [active] 1095774002914 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1095774002915 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1095774002916 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1095774002917 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1095774002918 baseplate wedge subunit; Provisional; Region: W; PHA02516 1095774002919 baseplate assembly protein; Provisional; Region: J; PHA02568 1095774002920 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 1095774002921 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1095774002922 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1095774002923 major tail sheath protein; Provisional; Region: FI; PHA02560 1095774002924 Phage tail tube protein FII; Region: Phage_tube; cl01390 1095774002925 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1095774002926 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1095774002927 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1095774002928 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1095774002929 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1095774002930 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1095774002931 HicB family; Region: HicB; pfam05534 1095774002932 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1095774002933 DNA protecting protein DprA; Region: dprA; TIGR00732 1095774002934 integrase; Provisional; Region: int; PHA02601 1095774002935 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1095774002936 active site 1095774002937 DNA binding site [nucleotide binding] 1095774002938 Int/Topo IB signature motif; other site 1095774002939 Predicted transcriptional regulator [Transcription]; Region: COG2932 1095774002940 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1095774002941 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 1095774002942 Catalytic site [active] 1095774002943 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 1095774002944 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 1095774002945 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 1095774002946 DksA-like zinc finger domain containing protein; Region: PHA00080 1095774002947 DNA adenine methylase (dam); Region: dam; TIGR00571 1095774002948 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1095774002949 Active Sites [active] 1095774002950 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 1095774002951 DinI-like family; Region: DinI; cl11630 1095774002952 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774002953 AAA domain; Region: AAA_23; pfam13476 1095774002954 Walker A/P-loop; other site 1095774002955 ATP binding site [chemical binding]; other site 1095774002956 AAA domain; Region: AAA_21; pfam13304 1095774002957 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774002958 Walker B; other site 1095774002959 D-loop; other site 1095774002960 H-loop/switch region; other site 1095774002961 portal vertex protein; Provisional; Region: Q; PHA02536 1095774002962 Phage portal protein; Region: Phage_portal; pfam04860 1095774002963 terminase ATPase subunit; Provisional; Region: P; PHA02535 1095774002964 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1095774002965 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 1095774002966 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 1095774002967 capsid protein; Provisional; Region: N; PHA02538 1095774002968 terminase endonuclease subunit; Provisional; Region: M; PHA02537 1095774002969 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 1095774002970 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 1095774002971 Phage Tail Protein X; Region: Phage_tail_X; cl02088 1095774002972 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1095774002973 catalytic residues [active] 1095774002974 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1095774002975 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1095774002976 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 1095774002977 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1095774002978 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1095774002979 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1095774002980 Baseplate J-like protein; Region: Baseplate_J; cl01294 1095774002981 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 1095774002982 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 1095774002983 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1095774002984 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1095774002985 major tail sheath protein; Provisional; Region: FI; PHA02560 1095774002986 major tail tube protein; Provisional; Region: FII; PHA02600 1095774002987 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1095774002988 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1095774002989 Flagellar FliJ protein; Region: FliJ; pfam02050 1095774002990 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1095774002991 Phage protein U [General function prediction only]; Region: COG3499 1095774002992 tail protein; Provisional; Region: D; PHA02561 1095774002993 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 1095774002994 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1095774002995 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1095774002996 active site 1095774002997 SUMO-1 interface [polypeptide binding]; other site 1095774002998 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1095774002999 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1095774003000 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1095774003001 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1095774003002 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1095774003003 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1095774003004 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1095774003005 DNA binding residues [nucleotide binding] 1095774003006 DNA primase; Validated; Region: dnaG; PRK05667 1095774003007 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1095774003008 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1095774003009 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1095774003010 active site 1095774003011 metal binding site [ion binding]; metal-binding site 1095774003012 interdomain interaction site; other site 1095774003013 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1095774003014 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1095774003015 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1095774003016 UGMP family protein; Validated; Region: PRK09604 1095774003017 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1095774003018 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1095774003019 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1095774003020 homooctamer interface [polypeptide binding]; other site 1095774003021 active site 1095774003022 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1095774003023 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1095774003024 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1095774003025 active site 1095774003026 NTP binding site [chemical binding]; other site 1095774003027 metal binding triad [ion binding]; metal-binding site 1095774003028 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1095774003029 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1095774003030 Zn2+ binding site [ion binding]; other site 1095774003031 Mg2+ binding site [ion binding]; other site 1095774003032 SH3 domain-containing protein; Provisional; Region: PRK10884 1095774003033 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1095774003034 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1095774003035 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1095774003036 putative active site [active] 1095774003037 putative metal binding residues [ion binding]; other site 1095774003038 signature motif; other site 1095774003039 putative triphosphate binding site [ion binding]; other site 1095774003040 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1095774003041 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1095774003042 metal binding triad; other site 1095774003043 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1095774003044 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1095774003045 metal binding triad; other site 1095774003046 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1095774003047 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1095774003048 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1095774003049 putative ribose interaction site [chemical binding]; other site 1095774003050 putative ADP binding site [chemical binding]; other site 1095774003051 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1095774003052 active site 1095774003053 nucleotide binding site [chemical binding]; other site 1095774003054 HIGH motif; other site 1095774003055 KMSKS motif; other site 1095774003056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1095774003057 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1095774003058 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1095774003059 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1095774003060 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1095774003061 putative active site [active] 1095774003062 metal binding site [ion binding]; metal-binding site 1095774003063 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1095774003064 hypothetical protein; Provisional; Region: PRK11653 1095774003065 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1095774003066 Legionella pneumophila major outer membrane protein precursor; Region: Legionella_OMP; pfam05150 1095774003067 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1095774003068 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1095774003069 dimer interface [polypeptide binding]; other site 1095774003070 ADP-ribose binding site [chemical binding]; other site 1095774003071 active site 1095774003072 nudix motif; other site 1095774003073 metal binding site [ion binding]; metal-binding site 1095774003074 putative dehydrogenase; Provisional; Region: PRK11039 1095774003075 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1095774003076 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1095774003077 active site 1095774003078 metal binding site [ion binding]; metal-binding site 1095774003079 hexamer interface [polypeptide binding]; other site 1095774003080 esterase YqiA; Provisional; Region: PRK11071 1095774003081 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1095774003082 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 1095774003083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774003084 ATP binding site [chemical binding]; other site 1095774003085 Mg2+ binding site [ion binding]; other site 1095774003086 G-X-G motif; other site 1095774003087 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1095774003088 anchoring element; other site 1095774003089 dimer interface [polypeptide binding]; other site 1095774003090 ATP binding site [chemical binding]; other site 1095774003091 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1095774003092 active site 1095774003093 metal binding site [ion binding]; metal-binding site 1095774003094 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1095774003095 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1095774003096 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1095774003097 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1095774003098 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774003099 substrate binding pocket [chemical binding]; other site 1095774003100 membrane-bound complex binding site; other site 1095774003101 hinge residues; other site 1095774003102 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1095774003103 intersubunit interface [polypeptide binding]; other site 1095774003104 active site 1095774003105 zinc binding site [ion binding]; other site 1095774003106 Na+ binding site [ion binding]; other site 1095774003107 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1095774003108 intersubunit interface [polypeptide binding]; other site 1095774003109 active site 1095774003110 zinc binding site [ion binding]; other site 1095774003111 Na+ binding site [ion binding]; other site 1095774003112 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1095774003113 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1095774003114 active site 1095774003115 P-loop; other site 1095774003116 phosphorylation site [posttranslational modification] 1095774003117 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1095774003118 active site 1095774003119 phosphorylation site [posttranslational modification] 1095774003120 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1095774003121 PRD domain; Region: PRD; pfam00874 1095774003122 PRD domain; Region: PRD; pfam00874 1095774003123 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1095774003124 active site 1095774003125 P-loop; other site 1095774003126 phosphorylation site [posttranslational modification] 1095774003127 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1095774003128 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1095774003129 CAP-like domain; other site 1095774003130 active site 1095774003131 primary dimer interface [polypeptide binding]; other site 1095774003132 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1095774003133 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1095774003134 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1095774003135 putative acyl-acceptor binding pocket; other site 1095774003136 FtsI repressor; Provisional; Region: PRK10883 1095774003137 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1095774003138 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1095774003139 flagellin; Provisional; Region: PRK12802 1095774003140 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1095774003141 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1095774003142 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1095774003143 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1095774003144 active site 1095774003145 catalytic tetrad [active] 1095774003146 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1095774003147 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1095774003148 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774003149 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774003150 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1095774003151 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1095774003152 cystathionine beta-lyase; Provisional; Region: PRK08114 1095774003153 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1095774003154 homodimer interface [polypeptide binding]; other site 1095774003155 substrate-cofactor binding pocket; other site 1095774003156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774003157 catalytic residue [active] 1095774003158 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1095774003159 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1095774003160 Bacterial transcriptional regulator; Region: IclR; pfam01614 1095774003161 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 1095774003162 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1095774003163 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1095774003164 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1095774003165 dimer interface [polypeptide binding]; other site 1095774003166 active site 1095774003167 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 1095774003168 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1095774003169 tetramer interface [polypeptide binding]; other site 1095774003170 active site 1095774003171 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1095774003172 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 1095774003173 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1095774003174 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774003175 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1095774003176 dimerization interface [polypeptide binding]; other site 1095774003177 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1095774003178 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1095774003179 heterodimer interface [polypeptide binding]; other site 1095774003180 active site 1095774003181 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 1095774003182 heterodimer interface [polypeptide binding]; other site 1095774003183 multimer interface [polypeptide binding]; other site 1095774003184 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1095774003185 active site 1095774003186 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1095774003187 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1095774003188 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1095774003189 dimer interface [polypeptide binding]; other site 1095774003190 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1095774003191 active site 1095774003192 Fe binding site [ion binding]; other site 1095774003193 benzoate transport; Region: 2A0115; TIGR00895 1095774003194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774003195 putative substrate translocation pore; other site 1095774003196 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1095774003197 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774003198 DNA binding site [nucleotide binding] 1095774003199 domain linker motif; other site 1095774003200 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1095774003201 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1095774003202 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1095774003203 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1095774003204 active site turn [active] 1095774003205 phosphorylation site [posttranslational modification] 1095774003206 biopolymer transport protein ExbB; Provisional; Region: PRK10414 1095774003207 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1095774003208 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1095774003209 citrate-proton symporter; Provisional; Region: PRK15075 1095774003210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774003211 putative substrate translocation pore; other site 1095774003212 Spore Coat Protein U domain; Region: SCPU; cl02253 1095774003213 Spore Coat Protein U domain; Region: SCPU; pfam05229 1095774003214 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1095774003215 PapC N-terminal domain; Region: PapC_N; pfam13954 1095774003216 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1095774003217 PapC C-terminal domain; Region: PapC_C; pfam13953 1095774003218 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1095774003219 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1095774003220 Spore Coat Protein U domain; Region: SCPU; pfam05229 1095774003221 Spore Coat Protein U domain; Region: SCPU; pfam05229 1095774003222 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1095774003223 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1095774003224 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1095774003225 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1095774003226 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1095774003227 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1095774003228 metal binding site [ion binding]; metal-binding site 1095774003229 active site 1095774003230 I-site; other site 1095774003231 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1095774003232 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1095774003233 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774003234 DNA-binding site [nucleotide binding]; DNA binding site 1095774003235 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1095774003236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774003237 homodimer interface [polypeptide binding]; other site 1095774003238 catalytic residue [active] 1095774003239 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1095774003240 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1095774003241 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1095774003242 metal binding site [ion binding]; metal-binding site 1095774003243 dimer interface [polypeptide binding]; other site 1095774003244 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1095774003245 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1095774003246 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1095774003247 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1095774003248 metal binding site [ion binding]; metal-binding site 1095774003249 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1095774003250 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1095774003251 active site 1095774003252 non-prolyl cis peptide bond; other site 1095774003253 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1095774003254 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774003255 substrate binding pocket [chemical binding]; other site 1095774003256 membrane-bound complex binding site; other site 1095774003257 hinge residues; other site 1095774003258 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1095774003259 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774003260 Coenzyme A binding pocket [chemical binding]; other site 1095774003261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774003262 dimer interface [polypeptide binding]; other site 1095774003263 conserved gate region; other site 1095774003264 putative PBP binding loops; other site 1095774003265 ABC-ATPase subunit interface; other site 1095774003266 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1095774003267 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1095774003268 Walker A/P-loop; other site 1095774003269 ATP binding site [chemical binding]; other site 1095774003270 Q-loop/lid; other site 1095774003271 ABC transporter signature motif; other site 1095774003272 Walker B; other site 1095774003273 D-loop; other site 1095774003274 H-loop/switch region; other site 1095774003275 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774003276 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1095774003277 substrate binding pocket [chemical binding]; other site 1095774003278 membrane-bound complex binding site; other site 1095774003279 hinge residues; other site 1095774003280 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 1095774003281 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 1095774003282 putative acyl-acceptor binding pocket; other site 1095774003283 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1095774003284 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1095774003285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774003286 Walker A/P-loop; other site 1095774003287 ATP binding site [chemical binding]; other site 1095774003288 Q-loop/lid; other site 1095774003289 ABC transporter signature motif; other site 1095774003290 Walker B; other site 1095774003291 D-loop; other site 1095774003292 H-loop/switch region; other site 1095774003293 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1095774003294 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1095774003295 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1095774003296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774003297 dimer interface [polypeptide binding]; other site 1095774003298 conserved gate region; other site 1095774003299 putative PBP binding loops; other site 1095774003300 ABC-ATPase subunit interface; other site 1095774003301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774003302 dimer interface [polypeptide binding]; other site 1095774003303 conserved gate region; other site 1095774003304 putative PBP binding loops; other site 1095774003305 ABC-ATPase subunit interface; other site 1095774003306 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1095774003307 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1095774003308 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774003309 DNA binding site [nucleotide binding] 1095774003310 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1095774003311 ligand binding site [chemical binding]; other site 1095774003312 dimerization interface [polypeptide binding]; other site 1095774003313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774003314 D-galactonate transporter; Region: 2A0114; TIGR00893 1095774003315 putative substrate translocation pore; other site 1095774003316 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1095774003317 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1095774003318 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 1095774003319 putative active site [active] 1095774003320 putative catalytic site [active] 1095774003321 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1095774003322 Ferritin-like domain; Region: Ferritin; pfam00210 1095774003323 ferroxidase diiron center [ion binding]; other site 1095774003324 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1095774003325 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1095774003326 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1095774003327 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1095774003328 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1095774003329 G1 box; other site 1095774003330 putative GEF interaction site [polypeptide binding]; other site 1095774003331 GTP/Mg2+ binding site [chemical binding]; other site 1095774003332 Switch I region; other site 1095774003333 G2 box; other site 1095774003334 G3 box; other site 1095774003335 Switch II region; other site 1095774003336 G4 box; other site 1095774003337 G5 box; other site 1095774003338 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1095774003339 periplasmic protein; Provisional; Region: PRK10568 1095774003340 BON domain; Region: BON; pfam04972 1095774003341 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1095774003342 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1095774003343 active site 1095774003344 nucleophile elbow; other site 1095774003345 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1095774003346 active site 1095774003347 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1095774003348 intersubunit interface [polypeptide binding]; other site 1095774003349 active site 1095774003350 catalytic residue [active] 1095774003351 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1095774003352 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1095774003353 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1095774003354 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1095774003355 phosphopentomutase; Provisional; Region: PRK05362 1095774003356 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1095774003357 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1095774003358 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1095774003359 penicillin-binding protein 2; Provisional; Region: PRK10795 1095774003360 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1095774003361 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1095774003362 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1095774003363 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1095774003364 metal binding site [ion binding]; metal-binding site 1095774003365 active site 1095774003366 I-site; other site 1095774003367 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 1095774003368 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1095774003369 FOG: CBS domain [General function prediction only]; Region: COG0517 1095774003370 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1095774003371 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1095774003372 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1095774003373 tetramer interface [polypeptide binding]; other site 1095774003374 active site 1095774003375 Mg2+/Mn2+ binding site [ion binding]; other site 1095774003376 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1095774003377 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1095774003378 active site 1095774003379 non-prolyl cis peptide bond; other site 1095774003380 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 1095774003381 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 1095774003382 active site 1095774003383 catalytic residues [active] 1095774003384 metal binding site [ion binding]; metal-binding site 1095774003385 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1095774003386 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1095774003387 substrate binding site [chemical binding]; other site 1095774003388 ligand binding site [chemical binding]; other site 1095774003389 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 1095774003390 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1095774003391 substrate binding site [chemical binding]; other site 1095774003392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774003393 S-adenosylmethionine binding site [chemical binding]; other site 1095774003394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774003395 Coenzyme A binding pocket [chemical binding]; other site 1095774003396 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1095774003397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774003398 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1095774003399 putative substrate translocation pore; other site 1095774003400 Flavin Reductases; Region: FlaRed; cl00801 1095774003401 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1095774003402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774003403 metabolite-proton symporter; Region: 2A0106; TIGR00883 1095774003404 putative substrate translocation pore; other site 1095774003405 hypothetical protein; Provisional; Region: PRK07079 1095774003406 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 1095774003407 metal binding site [ion binding]; metal-binding site 1095774003408 putative dimer interface [polypeptide binding]; other site 1095774003409 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774003410 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774003411 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1095774003412 dimerization interface [polypeptide binding]; other site 1095774003413 EamA-like transporter family; Region: EamA; pfam00892 1095774003414 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1095774003415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774003416 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1095774003417 putative substrate translocation pore; other site 1095774003418 Predicted transcriptional regulators [Transcription]; Region: COG1733 1095774003419 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1095774003420 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 1095774003421 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 1095774003422 active site 1095774003423 catalytic residues [active] 1095774003424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 1095774003425 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 1095774003426 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1095774003427 PAS domain; Region: PAS_9; pfam13426 1095774003428 putative active site [active] 1095774003429 heme pocket [chemical binding]; other site 1095774003430 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1095774003431 PAS domain; Region: PAS_9; pfam13426 1095774003432 putative active site [active] 1095774003433 heme pocket [chemical binding]; other site 1095774003434 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1095774003435 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774003436 dimer interface [polypeptide binding]; other site 1095774003437 putative CheW interface [polypeptide binding]; other site 1095774003438 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1095774003439 PAS domain; Region: PAS_9; pfam13426 1095774003440 putative active site [active] 1095774003441 heme pocket [chemical binding]; other site 1095774003442 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1095774003443 PAS domain; Region: PAS_9; pfam13426 1095774003444 putative active site [active] 1095774003445 heme pocket [chemical binding]; other site 1095774003446 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1095774003447 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774003448 dimer interface [polypeptide binding]; other site 1095774003449 putative CheW interface [polypeptide binding]; other site 1095774003450 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1095774003451 active site 1095774003452 CHASE3 domain; Region: CHASE3; pfam05227 1095774003453 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1095774003454 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774003455 dimer interface [polypeptide binding]; other site 1095774003456 putative CheW interface [polypeptide binding]; other site 1095774003457 hypothetical protein; Provisional; Region: PRK10316 1095774003458 YfdX protein; Region: YfdX; pfam10938 1095774003459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1095774003460 putative active site [active] 1095774003461 PAS fold; Region: PAS_3; pfam08447 1095774003462 heme pocket [chemical binding]; other site 1095774003463 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1095774003464 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1095774003465 metal binding site [ion binding]; metal-binding site 1095774003466 active site 1095774003467 I-site; other site 1095774003468 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1095774003469 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1095774003470 TAP-like protein; Region: Abhydrolase_4; pfam08386 1095774003471 General stress protein [General function prediction only]; Region: GsiB; COG3729 1095774003472 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1095774003473 dimerization interface [polypeptide binding]; other site 1095774003474 metal binding site [ion binding]; metal-binding site 1095774003475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 1095774003476 trehalase; Provisional; Region: treF; PRK13270 1095774003477 Trehalase; Region: Trehalase; cl17346 1095774003478 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1095774003479 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1095774003480 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1095774003481 putative DNA binding site [nucleotide binding]; other site 1095774003482 dimerization interface [polypeptide binding]; other site 1095774003483 putative Zn2+ binding site [ion binding]; other site 1095774003484 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1095774003485 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1095774003486 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1095774003487 NADP binding site [chemical binding]; other site 1095774003488 Predicted transcriptional regulators [Transcription]; Region: COG1733 1095774003489 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1095774003490 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1095774003491 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1095774003492 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1095774003493 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1095774003494 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1095774003495 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774003496 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1095774003497 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1095774003498 FAD binding pocket [chemical binding]; other site 1095774003499 FAD binding motif [chemical binding]; other site 1095774003500 phosphate binding motif [ion binding]; other site 1095774003501 NAD binding pocket [chemical binding]; other site 1095774003502 Predicted transcriptional regulators [Transcription]; Region: COG1695 1095774003503 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1095774003504 Rdx family; Region: Rdx; cl01407 1095774003505 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1095774003506 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1095774003507 NADP binding site [chemical binding]; other site 1095774003508 dimer interface [polypeptide binding]; other site 1095774003509 ornithine decarboxylase; Provisional; Region: PRK13578 1095774003510 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1095774003511 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1095774003512 homodimer interface [polypeptide binding]; other site 1095774003513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774003514 catalytic residue [active] 1095774003515 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1095774003516 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1095774003517 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1095774003518 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1095774003519 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1095774003520 catalytic residue [active] 1095774003521 oxidative damage protection protein; Provisional; Region: PRK05408 1095774003522 adenine DNA glycosylase; Provisional; Region: PRK10880 1095774003523 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1095774003524 minor groove reading motif; other site 1095774003525 helix-hairpin-helix signature motif; other site 1095774003526 substrate binding pocket [chemical binding]; other site 1095774003527 active site 1095774003528 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1095774003529 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1095774003530 DNA binding and oxoG recognition site [nucleotide binding] 1095774003531 melibiose:sodium symporter; Provisional; Region: PRK10429 1095774003532 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1095774003533 alpha-galactosidase; Provisional; Region: PRK15076 1095774003534 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1095774003535 NAD binding site [chemical binding]; other site 1095774003536 sugar binding site [chemical binding]; other site 1095774003537 divalent metal binding site [ion binding]; other site 1095774003538 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1095774003539 dimer interface [polypeptide binding]; other site 1095774003540 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 1095774003541 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774003542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774003543 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 1095774003544 hypothetical protein; Provisional; Region: PRK11702 1095774003545 hypothetical protein; Provisional; Region: PRK10626 1095774003546 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1095774003547 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1095774003548 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1095774003549 active site 1095774003550 P-loop; other site 1095774003551 phosphorylation site [posttranslational modification] 1095774003552 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1095774003553 active site 1095774003554 phosphorylation site [posttranslational modification] 1095774003555 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 1095774003556 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774003557 DNA-binding site [nucleotide binding]; DNA binding site 1095774003558 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1095774003559 HemN family oxidoreductase; Provisional; Region: PRK05660 1095774003560 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1095774003561 FeS/SAM binding site; other site 1095774003562 HemN C-terminal domain; Region: HemN_C; pfam06969 1095774003563 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1095774003564 active site 1095774003565 dimerization interface [polypeptide binding]; other site 1095774003566 YGGT family; Region: YGGT; pfam02325 1095774003567 Predicted integral membrane protein [Function unknown]; Region: COG0762 1095774003568 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1095774003569 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1095774003570 catalytic residue [active] 1095774003571 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1095774003572 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1095774003573 Walker A motif; other site 1095774003574 ATP binding site [chemical binding]; other site 1095774003575 Walker B motif; other site 1095774003576 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1095774003577 hypothetical protein; Validated; Region: PRK00228 1095774003578 glutathione synthetase; Provisional; Region: PRK05246 1095774003579 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1095774003580 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1095774003581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1095774003582 RNA methyltransferase, RsmE family; Region: TIGR00046 1095774003583 DNA-specific endonuclease I; Provisional; Region: PRK15137 1095774003584 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1095774003585 hypothetical protein; Provisional; Region: PRK04860 1095774003586 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1095774003587 Cache domain; Region: Cache_1; pfam02743 1095774003588 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1095774003589 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774003590 dimer interface [polypeptide binding]; other site 1095774003591 putative CheW interface [polypeptide binding]; other site 1095774003592 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1095774003593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774003594 putative substrate translocation pore; other site 1095774003595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774003596 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1095774003597 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1095774003598 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1095774003599 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1095774003600 arginine decarboxylase; Provisional; Region: PRK05354 1095774003601 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1095774003602 dimer interface [polypeptide binding]; other site 1095774003603 active site 1095774003604 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1095774003605 catalytic residues [active] 1095774003606 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1095774003607 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1095774003608 agmatinase; Region: agmatinase; TIGR01230 1095774003609 oligomer interface [polypeptide binding]; other site 1095774003610 putative active site [active] 1095774003611 Mn binding site [ion binding]; other site 1095774003612 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1095774003613 transketolase; Reviewed; Region: PRK12753 1095774003614 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1095774003615 TPP-binding site [chemical binding]; other site 1095774003616 dimer interface [polypeptide binding]; other site 1095774003617 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1095774003618 PYR/PP interface [polypeptide binding]; other site 1095774003619 dimer interface [polypeptide binding]; other site 1095774003620 TPP binding site [chemical binding]; other site 1095774003621 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1095774003622 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1095774003623 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1095774003624 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1095774003625 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1095774003626 Phosphoglycerate kinase; Region: PGK; pfam00162 1095774003627 substrate binding site [chemical binding]; other site 1095774003628 hinge regions; other site 1095774003629 ADP binding site [chemical binding]; other site 1095774003630 catalytic site [active] 1095774003631 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1095774003632 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1095774003633 active site 1095774003634 intersubunit interface [polypeptide binding]; other site 1095774003635 zinc binding site [ion binding]; other site 1095774003636 Na+ binding site [ion binding]; other site 1095774003637 mechanosensitive channel MscS; Provisional; Region: PRK10334 1095774003638 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1095774003639 LysE type translocator; Region: LysE; cl00565 1095774003640 oxidative stress defense protein; Provisional; Region: PRK11087 1095774003641 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1095774003642 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1095774003643 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774003644 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1095774003645 putative dimerization interface [polypeptide binding]; other site 1095774003646 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1095774003647 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1095774003648 active site 1095774003649 dimer interface [polypeptide binding]; other site 1095774003650 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1095774003651 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1095774003652 ligand binding site [chemical binding]; other site 1095774003653 NAD binding site [chemical binding]; other site 1095774003654 tetramer interface [polypeptide binding]; other site 1095774003655 catalytic site [active] 1095774003656 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1095774003657 L-serine binding site [chemical binding]; other site 1095774003658 ACT domain interface; other site 1095774003659 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1095774003660 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1095774003661 Z-ring-associated protein; Provisional; Region: PRK10972 1095774003662 hypothetical protein; Reviewed; Region: PRK01736 1095774003663 proline aminopeptidase P II; Provisional; Region: PRK10879 1095774003664 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1095774003665 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1095774003666 active site 1095774003667 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1095774003668 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1095774003669 oxidoreductase; Provisional; Region: PRK08013 1095774003670 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1095774003671 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1095774003672 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1095774003673 glycine cleavage system protein H; Provisional; Region: PRK13380 1095774003674 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1095774003675 lipoyl attachment site [posttranslational modification]; other site 1095774003676 glycine dehydrogenase; Provisional; Region: PRK05367 1095774003677 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1095774003678 tetramer interface [polypeptide binding]; other site 1095774003679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774003680 catalytic residue [active] 1095774003681 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1095774003682 tetramer interface [polypeptide binding]; other site 1095774003683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774003684 catalytic residue [active] 1095774003685 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 1095774003686 classical (c) SDRs; Region: SDR_c; cd05233 1095774003687 NAD(P) binding site [chemical binding]; other site 1095774003688 active site 1095774003689 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1095774003690 beta-galactosidase; Region: BGL; TIGR03356 1095774003691 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1095774003692 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1095774003693 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1095774003694 putative active site [active] 1095774003695 hemolysin; Provisional; Region: PRK15087 1095774003696 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1095774003697 putative global regulator; Reviewed; Region: PRK09559 1095774003698 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1095774003699 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 1095774003700 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1095774003701 flavodoxin FldB; Provisional; Region: PRK12359 1095774003702 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1095774003703 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1095774003704 active site 1095774003705 Int/Topo IB signature motif; other site 1095774003706 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1095774003707 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1095774003708 dimerization domain [polypeptide binding]; other site 1095774003709 dimer interface [polypeptide binding]; other site 1095774003710 catalytic residues [active] 1095774003711 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1095774003712 DHH family; Region: DHH; pfam01368 1095774003713 DHHA1 domain; Region: DHHA1; pfam02272 1095774003714 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1095774003715 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1095774003716 RF-1 domain; Region: RF-1; pfam00472 1095774003717 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1095774003718 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1095774003719 dimer interface [polypeptide binding]; other site 1095774003720 putative anticodon binding site; other site 1095774003721 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1095774003722 motif 1; other site 1095774003723 active site 1095774003724 motif 2; other site 1095774003725 motif 3; other site 1095774003726 Cupin domain; Region: Cupin_2; cl17218 1095774003727 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1095774003728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774003729 putative substrate translocation pore; other site 1095774003730 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1095774003731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774003732 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1095774003733 dimerization interface [polypeptide binding]; other site 1095774003734 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1095774003735 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1095774003736 active site 1095774003737 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1095774003738 substrate binding site [chemical binding]; other site 1095774003739 catalytic residues [active] 1095774003740 dimer interface [polypeptide binding]; other site 1095774003741 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1095774003742 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1095774003743 active site 1095774003744 catalytic tetrad [active] 1095774003745 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1095774003746 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1095774003747 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1095774003748 putative DNA-binding cleft [nucleotide binding]; other site 1095774003749 putative DNA clevage site; other site 1095774003750 molecular lever; other site 1095774003751 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1095774003752 putative active site [active] 1095774003753 Ap4A binding site [chemical binding]; other site 1095774003754 nudix motif; other site 1095774003755 putative metal binding site [ion binding]; other site 1095774003756 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1095774003757 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1095774003758 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1095774003759 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1095774003760 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1095774003761 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1095774003762 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1095774003763 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1095774003764 dimerization interface [polypeptide binding]; other site 1095774003765 active site 1095774003766 hypothetical protein; Provisional; Region: PRK10506 1095774003767 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1095774003768 hypothetical protein; Provisional; Region: PRK10557 1095774003769 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1095774003770 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 1095774003771 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 1095774003772 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 1095774003773 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1095774003774 protease3; Provisional; Region: PRK15101 1095774003775 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1095774003776 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1095774003777 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1095774003778 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1095774003779 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1095774003780 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1095774003781 AAA domain; Region: AAA_30; pfam13604 1095774003782 Family description; Region: UvrD_C_2; pfam13538 1095774003783 N-acetylglutamate synthase; Validated; Region: PRK05279 1095774003784 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1095774003785 putative feedback inhibition sensing region; other site 1095774003786 putative nucleotide binding site [chemical binding]; other site 1095774003787 putative substrate binding site [chemical binding]; other site 1095774003788 N-acetylglutamate synthase and related acetyltransferases [Amino acid transport and metabolism]; Region: ArgA; COG1246 1095774003789 AMIN domain; Region: AMIN; pfam11741 1095774003790 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1095774003791 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1095774003792 active site 1095774003793 metal binding site [ion binding]; metal-binding site 1095774003794 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1095774003795 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1095774003796 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1095774003797 catalytic residue [active] 1095774003798 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1095774003799 MltA specific insert domain; Region: MltA; smart00925 1095774003800 3D domain; Region: 3D; pfam06725 1095774003801 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1095774003802 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1095774003803 putative ATP binding site [chemical binding]; other site 1095774003804 putative substrate interface [chemical binding]; other site 1095774003805 cysteine desulfurase, sulfur acceptor subunit CsdE; Region: FeS_syn_CsdE; TIGR03391 1095774003806 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1095774003807 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1095774003808 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1095774003809 catalytic residue [active] 1095774003810 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1095774003811 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1095774003812 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774003813 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1095774003814 dimerization interface [polypeptide binding]; other site 1095774003815 substrate binding pocket [chemical binding]; other site 1095774003816 hypothetical protein; Provisional; Region: PRK10873 1095774003817 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1095774003818 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 1095774003819 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1095774003820 flap endonuclease-like protein; Provisional; Region: PRK09482 1095774003821 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1095774003822 active site 1095774003823 metal binding site 1 [ion binding]; metal-binding site 1095774003824 putative 5' ssDNA interaction site; other site 1095774003825 metal binding site 3; metal-binding site 1095774003826 metal binding site 2 [ion binding]; metal-binding site 1095774003827 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1095774003828 putative DNA binding site [nucleotide binding]; other site 1095774003829 putative metal binding site [ion binding]; other site 1095774003830 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1095774003831 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1095774003832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1095774003833 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1095774003834 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1095774003835 SecY interacting protein Syd; Provisional; Region: PRK04968 1095774003836 tRNA pseudouridine synthase C; Region: DUF446; cl01187 1095774003837 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1095774003838 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1095774003839 probable active site [active] 1095774003840 flavodoxin; Provisional; Region: PRK08105 1095774003841 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1095774003842 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1095774003843 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1095774003844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774003845 D-galactonate transporter; Region: 2A0114; TIGR00893 1095774003846 putative substrate translocation pore; other site 1095774003847 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1095774003848 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1095774003849 active site 1095774003850 tetramer interface [polypeptide binding]; other site 1095774003851 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1095774003852 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1095774003853 active site 1095774003854 tetramer interface [polypeptide binding]; other site 1095774003855 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1095774003856 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 1095774003857 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1095774003858 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1095774003859 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1095774003860 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1095774003861 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774003862 dimerization interface [polypeptide binding]; other site 1095774003863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1095774003864 dimer interface [polypeptide binding]; other site 1095774003865 phosphorylation site [posttranslational modification] 1095774003866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774003867 ATP binding site [chemical binding]; other site 1095774003868 Mg2+ binding site [ion binding]; other site 1095774003869 G-X-G motif; other site 1095774003870 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 1095774003871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774003872 active site 1095774003873 phosphorylation site [posttranslational modification] 1095774003874 intermolecular recognition site; other site 1095774003875 dimerization interface [polypeptide binding]; other site 1095774003876 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1095774003877 putative binding surface; other site 1095774003878 active site 1095774003879 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1095774003880 TRAM domain; Region: TRAM; pfam01938 1095774003881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774003882 S-adenosylmethionine binding site [chemical binding]; other site 1095774003883 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1095774003884 HD domain; Region: HD_4; pfam13328 1095774003885 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1095774003886 synthetase active site [active] 1095774003887 NTP binding site [chemical binding]; other site 1095774003888 metal binding site [ion binding]; metal-binding site 1095774003889 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1095774003890 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1095774003891 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1095774003892 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1095774003893 homodimer interface [polypeptide binding]; other site 1095774003894 metal binding site [ion binding]; metal-binding site 1095774003895 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1095774003896 homodimer interface [polypeptide binding]; other site 1095774003897 active site 1095774003898 putative chemical substrate binding site [chemical binding]; other site 1095774003899 metal binding site [ion binding]; metal-binding site 1095774003900 CTP synthetase; Validated; Region: pyrG; PRK05380 1095774003901 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1095774003902 Catalytic site [active] 1095774003903 active site 1095774003904 UTP binding site [chemical binding]; other site 1095774003905 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1095774003906 active site 1095774003907 putative oxyanion hole; other site 1095774003908 catalytic triad [active] 1095774003909 enolase; Provisional; Region: eno; PRK00077 1095774003910 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1095774003911 dimer interface [polypeptide binding]; other site 1095774003912 metal binding site [ion binding]; metal-binding site 1095774003913 substrate binding pocket [chemical binding]; other site 1095774003914 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1095774003915 putative catalytic site [active] 1095774003916 putative phosphate binding site [ion binding]; other site 1095774003917 putative metal binding site [ion binding]; other site 1095774003918 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1095774003919 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1095774003920 metal binding site [ion binding]; metal-binding site 1095774003921 dimer interface [polypeptide binding]; other site 1095774003922 hypothetical protein; Provisional; Region: PRK10519 1095774003923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1095774003924 Nucleoside recognition; Region: Gate; pfam07670 1095774003925 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1095774003926 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1095774003927 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1095774003928 dimer interface [polypeptide binding]; other site 1095774003929 substrate binding site [chemical binding]; other site 1095774003930 metal binding sites [ion binding]; metal-binding site 1095774003931 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1095774003932 active site 1095774003933 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1095774003934 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1095774003935 Flavodoxin; Region: Flavodoxin_1; pfam00258 1095774003936 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1095774003937 FAD binding pocket [chemical binding]; other site 1095774003938 FAD binding motif [chemical binding]; other site 1095774003939 catalytic residues [active] 1095774003940 NAD binding pocket [chemical binding]; other site 1095774003941 phosphate binding motif [ion binding]; other site 1095774003942 beta-alpha-beta structure motif; other site 1095774003943 sulfite reductase subunit beta; Provisional; Region: PRK13504 1095774003944 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1095774003945 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1095774003946 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1095774003947 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1095774003948 Active Sites [active] 1095774003949 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1095774003950 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 1095774003951 active site 1095774003952 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1095774003953 dimer interface [polypeptide binding]; other site 1095774003954 substrate binding site [chemical binding]; other site 1095774003955 catalytic residue [active] 1095774003956 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1095774003957 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1095774003958 Walker A/P-loop; other site 1095774003959 ATP binding site [chemical binding]; other site 1095774003960 Q-loop/lid; other site 1095774003961 ABC transporter signature motif; other site 1095774003962 Walker B; other site 1095774003963 D-loop; other site 1095774003964 H-loop/switch region; other site 1095774003965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774003966 dimer interface [polypeptide binding]; other site 1095774003967 conserved gate region; other site 1095774003968 putative PBP binding loops; other site 1095774003969 ABC-ATPase subunit interface; other site 1095774003970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774003971 dimer interface [polypeptide binding]; other site 1095774003972 conserved gate region; other site 1095774003973 putative PBP binding loops; other site 1095774003974 ABC-ATPase subunit interface; other site 1095774003975 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1095774003976 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774003977 substrate binding pocket [chemical binding]; other site 1095774003978 membrane-bound complex binding site; other site 1095774003979 hinge residues; other site 1095774003980 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1095774003981 homotrimer interaction site [polypeptide binding]; other site 1095774003982 putative active site [active] 1095774003983 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1095774003984 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1095774003985 Bacterial transcriptional regulator; Region: IclR; pfam01614 1095774003986 YCII-related domain; Region: YCII; cl00999 1095774003987 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1095774003988 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1095774003989 metal binding site [ion binding]; metal-binding site 1095774003990 siroheme synthase; Provisional; Region: cysG; PRK10637 1095774003991 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1095774003992 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1095774003993 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1095774003994 active site 1095774003995 SAM binding site [chemical binding]; other site 1095774003996 homodimer interface [polypeptide binding]; other site 1095774003997 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1095774003998 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1095774003999 Active Sites [active] 1095774004000 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1095774004001 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1095774004002 CysD dimerization site [polypeptide binding]; other site 1095774004003 G1 box; other site 1095774004004 putative GEF interaction site [polypeptide binding]; other site 1095774004005 GTP/Mg2+ binding site [chemical binding]; other site 1095774004006 Switch I region; other site 1095774004007 G2 box; other site 1095774004008 G3 box; other site 1095774004009 Switch II region; other site 1095774004010 G4 box; other site 1095774004011 G5 box; other site 1095774004012 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1095774004013 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1095774004014 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1095774004015 ligand-binding site [chemical binding]; other site 1095774004016 hypothetical protein; Provisional; Region: PRK10726 1095774004017 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1095774004018 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1095774004019 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1095774004020 substrate binding site; other site 1095774004021 dimer interface; other site 1095774004022 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1095774004023 homotrimer interaction site [polypeptide binding]; other site 1095774004024 zinc binding site [ion binding]; other site 1095774004025 CDP-binding sites; other site 1095774004026 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1095774004027 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1095774004028 Permutation of conserved domain; other site 1095774004029 active site 1095774004030 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1095774004031 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1095774004032 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1095774004033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774004034 S-adenosylmethionine binding site [chemical binding]; other site 1095774004035 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1095774004036 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1095774004037 Peptidase family M23; Region: Peptidase_M23; pfam01551 1095774004038 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1095774004039 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1095774004040 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1095774004041 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1095774004042 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1095774004043 DNA binding residues [nucleotide binding] 1095774004044 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 1095774004045 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1095774004046 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1095774004047 non-specific DNA binding site [nucleotide binding]; other site 1095774004048 salt bridge; other site 1095774004049 sequence-specific DNA binding site [nucleotide binding]; other site 1095774004050 2TM domain; Region: 2TM; pfam13239 1095774004051 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1095774004052 MutS domain I; Region: MutS_I; pfam01624 1095774004053 MutS domain II; Region: MutS_II; pfam05188 1095774004054 MutS domain III; Region: MutS_III; pfam05192 1095774004055 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1095774004056 Walker A/P-loop; other site 1095774004057 ATP binding site [chemical binding]; other site 1095774004058 Q-loop/lid; other site 1095774004059 ABC transporter signature motif; other site 1095774004060 Walker B; other site 1095774004061 D-loop; other site 1095774004062 H-loop/switch region; other site 1095774004063 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1095774004064 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1095774004065 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1095774004066 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1095774004067 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1095774004068 PhnA protein; Region: PhnA; pfam03831 1095774004069 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1095774004070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774004071 S-adenosylmethionine binding site [chemical binding]; other site 1095774004072 hypothetical protein; Validated; Region: PRK03661 1095774004073 recombinase A; Provisional; Region: recA; PRK09354 1095774004074 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1095774004075 hexamer interface [polypeptide binding]; other site 1095774004076 Walker A motif; other site 1095774004077 ATP binding site [chemical binding]; other site 1095774004078 Walker B motif; other site 1095774004079 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1095774004080 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1095774004081 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1095774004082 motif 1; other site 1095774004083 active site 1095774004084 motif 2; other site 1095774004085 motif 3; other site 1095774004086 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1095774004087 DHHA1 domain; Region: DHHA1; pfam02272 1095774004088 carbon storage regulator; Provisional; Region: PRK01712 1095774004089 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1095774004090 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774004091 motif II; other site 1095774004092 Predicted membrane protein [Function unknown]; Region: COG1238 1095774004093 glutamate--cysteine ligase; Provisional; Region: PRK02107 1095774004094 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1095774004095 hypothetical protein; Provisional; Region: PRK11573 1095774004096 Domain of unknown function DUF21; Region: DUF21; pfam01595 1095774004097 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1095774004098 Transporter associated domain; Region: CorC_HlyC; smart01091 1095774004099 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1095774004100 signal recognition particle protein; Provisional; Region: PRK10867 1095774004101 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1095774004102 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1095774004103 P loop; other site 1095774004104 GTP binding site [chemical binding]; other site 1095774004105 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1095774004106 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1095774004107 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1095774004108 RimM N-terminal domain; Region: RimM; pfam01782 1095774004109 PRC-barrel domain; Region: PRC; pfam05239 1095774004110 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1095774004111 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1095774004112 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1095774004113 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1095774004114 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1095774004115 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1095774004116 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1095774004117 Chorismate mutase type II; Region: CM_2; cl00693 1095774004118 prephenate dehydrogenase; Validated; Region: PRK08507 1095774004119 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1095774004120 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1095774004121 Prephenate dehydratase; Region: PDT; pfam00800 1095774004122 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1095774004123 putative L-Phe binding site [chemical binding]; other site 1095774004124 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1095774004125 30S subunit binding site; other site 1095774004126 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1095774004127 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1095774004128 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1095774004129 RNA binding surface [nucleotide binding]; other site 1095774004130 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1095774004131 active site 1095774004132 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1095774004133 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1095774004134 protein disaggregation chaperone; Provisional; Region: PRK10865 1095774004135 Clp amino terminal domain; Region: Clp_N; pfam02861 1095774004136 Clp amino terminal domain; Region: Clp_N; pfam02861 1095774004137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774004138 Walker A motif; other site 1095774004139 ATP binding site [chemical binding]; other site 1095774004140 Walker B motif; other site 1095774004141 arginine finger; other site 1095774004142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774004143 Walker A motif; other site 1095774004144 ATP binding site [chemical binding]; other site 1095774004145 Walker B motif; other site 1095774004146 arginine finger; other site 1095774004147 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1095774004148 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1095774004149 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1095774004150 putative DNA binding site [nucleotide binding]; other site 1095774004151 putative Zn2+ binding site [ion binding]; other site 1095774004152 AsnC family; Region: AsnC_trans_reg; pfam01037 1095774004153 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1095774004154 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 1095774004155 putative NAD(P) binding site [chemical binding]; other site 1095774004156 catalytic Zn binding site [ion binding]; other site 1095774004157 structural Zn binding site [ion binding]; other site 1095774004158 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1095774004159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774004160 putative substrate translocation pore; other site 1095774004161 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1095774004162 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1095774004163 domain interface [polypeptide binding]; other site 1095774004164 putative active site [active] 1095774004165 catalytic site [active] 1095774004166 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1095774004167 domain interface [polypeptide binding]; other site 1095774004168 putative active site [active] 1095774004169 catalytic site [active] 1095774004170 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1095774004171 CoA binding domain; Region: CoA_binding_2; pfam13380 1095774004172 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1095774004173 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1095774004174 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1095774004175 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1095774004176 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1095774004177 thioredoxin 2; Provisional; Region: PRK10996 1095774004178 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1095774004179 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1095774004180 catalytic residues [active] 1095774004181 putative methyltransferase; Provisional; Region: PRK10864 1095774004182 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1095774004183 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1095774004184 Predicted transcriptional regulators [Transcription]; Region: COG1733 1095774004185 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1095774004186 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1095774004187 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1095774004188 putative NAD(P) binding site [chemical binding]; other site 1095774004189 putative substrate binding site [chemical binding]; other site 1095774004190 catalytic Zn binding site [ion binding]; other site 1095774004191 structural Zn binding site [ion binding]; other site 1095774004192 dimer interface [polypeptide binding]; other site 1095774004193 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1095774004194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774004195 putative substrate translocation pore; other site 1095774004196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774004197 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1095774004198 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1095774004199 HlyD family secretion protein; Region: HlyD_3; pfam13437 1095774004200 transcriptional repressor MprA; Provisional; Region: PRK10870 1095774004201 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1095774004202 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1095774004203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774004204 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1095774004205 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1095774004206 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1095774004207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774004208 dimer interface [polypeptide binding]; other site 1095774004209 conserved gate region; other site 1095774004210 putative PBP binding loops; other site 1095774004211 ABC-ATPase subunit interface; other site 1095774004212 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1095774004213 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1095774004214 Walker A/P-loop; other site 1095774004215 ATP binding site [chemical binding]; other site 1095774004216 Q-loop/lid; other site 1095774004217 ABC transporter signature motif; other site 1095774004218 Walker B; other site 1095774004219 D-loop; other site 1095774004220 H-loop/switch region; other site 1095774004221 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1095774004222 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1095774004223 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1095774004224 dimer interface [polypeptide binding]; other site 1095774004225 putative radical transfer pathway; other site 1095774004226 diiron center [ion binding]; other site 1095774004227 tyrosyl radical; other site 1095774004228 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1095774004229 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1095774004230 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1095774004231 active site 1095774004232 dimer interface [polypeptide binding]; other site 1095774004233 catalytic residues [active] 1095774004234 effector binding site; other site 1095774004235 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1095774004236 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1095774004237 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1095774004238 catalytic residues [active] 1095774004239 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 1095774004240 hypothetical protein; Provisional; Region: PRK10556 1095774004241 S-methylmethionine transporter; Provisional; Region: PRK11387 1095774004242 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1095774004243 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1095774004244 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1095774004245 PEGA domain; Region: PEGA; pfam08308 1095774004246 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1095774004247 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774004248 Coenzyme A binding pocket [chemical binding]; other site 1095774004249 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1095774004250 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1095774004251 Walker A/P-loop; other site 1095774004252 ATP binding site [chemical binding]; other site 1095774004253 Q-loop/lid; other site 1095774004254 ABC transporter signature motif; other site 1095774004255 Walker B; other site 1095774004256 D-loop; other site 1095774004257 H-loop/switch region; other site 1095774004258 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1095774004259 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1095774004260 Walker A/P-loop; other site 1095774004261 ATP binding site [chemical binding]; other site 1095774004262 Q-loop/lid; other site 1095774004263 ABC transporter signature motif; other site 1095774004264 Walker B; other site 1095774004265 D-loop; other site 1095774004266 H-loop/switch region; other site 1095774004267 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1095774004268 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1095774004269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774004270 dimer interface [polypeptide binding]; other site 1095774004271 conserved gate region; other site 1095774004272 ABC-ATPase subunit interface; other site 1095774004273 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1095774004274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774004275 dimer interface [polypeptide binding]; other site 1095774004276 conserved gate region; other site 1095774004277 putative PBP binding loops; other site 1095774004278 ABC-ATPase subunit interface; other site 1095774004279 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1095774004280 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1095774004281 magnesium-transporting ATPase; Provisional; Region: PRK15122 1095774004282 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1095774004283 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1095774004284 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1095774004285 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774004286 motif II; other site 1095774004287 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1095774004288 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1095774004289 DNA binding site [nucleotide binding] 1095774004290 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1095774004291 FaeA-like protein; Region: FaeA; pfam04703 1095774004292 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1095774004293 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1095774004294 Walker A/P-loop; other site 1095774004295 ATP binding site [chemical binding]; other site 1095774004296 Q-loop/lid; other site 1095774004297 ABC transporter signature motif; other site 1095774004298 Walker B; other site 1095774004299 D-loop; other site 1095774004300 H-loop/switch region; other site 1095774004301 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1095774004302 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1095774004303 ABC-ATPase subunit interface; other site 1095774004304 dimer interface [polypeptide binding]; other site 1095774004305 putative PBP binding regions; other site 1095774004306 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1095774004307 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1095774004308 putative ligand binding residues [chemical binding]; other site 1095774004309 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 1095774004310 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1095774004311 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774004312 dimerization interface [polypeptide binding]; other site 1095774004313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1095774004314 dimer interface [polypeptide binding]; other site 1095774004315 phosphorylation site [posttranslational modification] 1095774004316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774004317 ATP binding site [chemical binding]; other site 1095774004318 Mg2+ binding site [ion binding]; other site 1095774004319 G-X-G motif; other site 1095774004320 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1095774004321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774004322 active site 1095774004323 phosphorylation site [posttranslational modification] 1095774004324 intermolecular recognition site; other site 1095774004325 dimerization interface [polypeptide binding]; other site 1095774004326 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1095774004327 DNA binding site [nucleotide binding] 1095774004328 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1095774004329 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1095774004330 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1095774004331 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 1095774004332 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1095774004333 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1095774004334 trimer interface [polypeptide binding]; other site 1095774004335 eyelet of channel; other site 1095774004336 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1095774004337 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1095774004338 ligand binding site [chemical binding]; other site 1095774004339 NAD binding site [chemical binding]; other site 1095774004340 dimerization interface [polypeptide binding]; other site 1095774004341 catalytic site [active] 1095774004342 hypothetical protein; Validated; Region: PRK06201 1095774004343 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1095774004344 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1095774004345 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1095774004346 transmembrane helices; other site 1095774004347 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 1095774004348 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1095774004349 active site 1095774004350 Propionate catabolism activator; Region: PrpR_N; pfam06506 1095774004351 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1095774004352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774004353 Walker A motif; other site 1095774004354 ATP binding site [chemical binding]; other site 1095774004355 Walker B motif; other site 1095774004356 arginine finger; other site 1095774004357 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1095774004358 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774004359 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774004360 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1095774004361 putative effector binding pocket; other site 1095774004362 putative dimerization interface [polypeptide binding]; other site 1095774004363 hypothetical protein; Provisional; Region: PRK09739 1095774004364 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1095774004365 Right handed beta helix region; Region: Beta_helix; pfam13229 1095774004366 Predicted transcriptional regulators [Transcription]; Region: COG1733 1095774004367 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1095774004368 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1095774004369 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1095774004370 putative NAD(P) binding site [chemical binding]; other site 1095774004371 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1095774004372 active site 1095774004373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774004374 D-galactonate transporter; Region: 2A0114; TIGR00893 1095774004375 putative substrate translocation pore; other site 1095774004376 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1095774004377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774004378 putative substrate translocation pore; other site 1095774004379 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1095774004380 Strictosidine synthase; Region: Str_synth; pfam03088 1095774004381 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1095774004382 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1095774004383 ligand binding site [chemical binding]; other site 1095774004384 NAD binding site [chemical binding]; other site 1095774004385 dimerization interface [polypeptide binding]; other site 1095774004386 catalytic site [active] 1095774004387 hypothetical protein; Validated; Region: PRK06201 1095774004388 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1095774004389 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1095774004390 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1095774004391 Bacterial transcriptional regulator; Region: IclR; pfam01614 1095774004392 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1095774004393 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1095774004394 Walker A/P-loop; other site 1095774004395 ATP binding site [chemical binding]; other site 1095774004396 Q-loop/lid; other site 1095774004397 ABC transporter signature motif; other site 1095774004398 Walker B; other site 1095774004399 D-loop; other site 1095774004400 H-loop/switch region; other site 1095774004401 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1095774004402 ABC-ATPase subunit interface; other site 1095774004403 dimer interface [polypeptide binding]; other site 1095774004404 putative PBP binding regions; other site 1095774004405 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1095774004406 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1095774004407 ABC-ATPase subunit interface; other site 1095774004408 dimer interface [polypeptide binding]; other site 1095774004409 putative PBP binding regions; other site 1095774004410 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1095774004411 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1095774004412 putative ligand binding residues [chemical binding]; other site 1095774004413 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 1095774004414 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1095774004415 N-terminal plug; other site 1095774004416 ligand-binding site [chemical binding]; other site 1095774004417 haloalkane dehalogenase; Provisional; Region: PRK03592 1095774004418 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1095774004419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1095774004420 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1095774004421 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 1095774004422 hypothetical protein; Validated; Region: PRK06201 1095774004423 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1095774004424 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1095774004425 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1095774004426 transmembrane helices; other site 1095774004427 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1095774004428 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1095774004429 ligand binding site [chemical binding]; other site 1095774004430 NAD binding site [chemical binding]; other site 1095774004431 dimerization interface [polypeptide binding]; other site 1095774004432 catalytic site [active] 1095774004433 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774004434 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774004435 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1095774004436 dimerization interface [polypeptide binding]; other site 1095774004437 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1095774004438 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1095774004439 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 1095774004440 putative active site [active] 1095774004441 putative NTP binding site [chemical binding]; other site 1095774004442 putative nucleic acid binding site [nucleotide binding]; other site 1095774004443 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1095774004444 Uncharacterized conserved protein [Function unknown]; Region: COG4938 1095774004445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774004446 Walker A/P-loop; other site 1095774004447 ATP binding site [chemical binding]; other site 1095774004448 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 1095774004449 Protein of unknown function DUF262; Region: DUF262; pfam03235 1095774004450 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1095774004451 integrase; Provisional; Region: PRK09692 1095774004452 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1095774004453 active site 1095774004454 Int/Topo IB signature motif; other site 1095774004455 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1095774004456 SmpB-tmRNA interface; other site 1095774004457 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1095774004458 putative coenzyme Q binding site [chemical binding]; other site 1095774004459 hypothetical protein; Validated; Region: PRK01777 1095774004460 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1095774004461 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1095774004462 recombination and repair protein; Provisional; Region: PRK10869 1095774004463 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1095774004464 Walker A/P-loop; other site 1095774004465 ATP binding site [chemical binding]; other site 1095774004466 Q-loop/lid; other site 1095774004467 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1095774004468 Q-loop/lid; other site 1095774004469 ABC transporter signature motif; other site 1095774004470 Walker B; other site 1095774004471 D-loop; other site 1095774004472 H-loop/switch region; other site 1095774004473 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1095774004474 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1095774004475 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1095774004476 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1095774004477 dimer interface [polypeptide binding]; other site 1095774004478 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1095774004479 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1095774004480 ligand binding site [chemical binding]; other site 1095774004481 active site 1095774004482 UGI interface [polypeptide binding]; other site 1095774004483 catalytic site [active] 1095774004484 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1095774004485 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1095774004486 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1095774004487 ATP binding site [chemical binding]; other site 1095774004488 Mg++ binding site [ion binding]; other site 1095774004489 motif III; other site 1095774004490 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1095774004491 nucleotide binding region [chemical binding]; other site 1095774004492 ATP-binding site [chemical binding]; other site 1095774004493 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1095774004494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774004495 S-adenosylmethionine binding site [chemical binding]; other site 1095774004496 L-aspartate oxidase; Provisional; Region: PRK09077 1095774004497 L-aspartate oxidase; Provisional; Region: PRK06175 1095774004498 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1095774004499 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1095774004500 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1095774004501 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1095774004502 DNA binding residues [nucleotide binding] 1095774004503 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1095774004504 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1095774004505 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1095774004506 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1095774004507 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1095774004508 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1095774004509 GTP-binding protein LepA; Provisional; Region: PRK05433 1095774004510 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1095774004511 G1 box; other site 1095774004512 putative GEF interaction site [polypeptide binding]; other site 1095774004513 GTP/Mg2+ binding site [chemical binding]; other site 1095774004514 Switch I region; other site 1095774004515 G2 box; other site 1095774004516 G3 box; other site 1095774004517 Switch II region; other site 1095774004518 G4 box; other site 1095774004519 G5 box; other site 1095774004520 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1095774004521 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1095774004522 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1095774004523 signal peptidase I; Provisional; Region: PRK10861 1095774004524 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1095774004525 Catalytic site [active] 1095774004526 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1095774004527 ribonuclease III; Reviewed; Region: rnc; PRK00102 1095774004528 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1095774004529 dimerization interface [polypeptide binding]; other site 1095774004530 active site 1095774004531 metal binding site [ion binding]; metal-binding site 1095774004532 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1095774004533 dsRNA binding site [nucleotide binding]; other site 1095774004534 GTPase Era; Reviewed; Region: era; PRK00089 1095774004535 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1095774004536 G1 box; other site 1095774004537 GTP/Mg2+ binding site [chemical binding]; other site 1095774004538 Switch I region; other site 1095774004539 G2 box; other site 1095774004540 Switch II region; other site 1095774004541 G3 box; other site 1095774004542 G4 box; other site 1095774004543 G5 box; other site 1095774004544 KH domain; Region: KH_2; pfam07650 1095774004545 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1095774004546 Recombination protein O N terminal; Region: RecO_N; pfam11967 1095774004547 Recombination protein O C terminal; Region: RecO_C; pfam02565 1095774004548 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1095774004549 active site 1095774004550 hydrophilic channel; other site 1095774004551 dimerization interface [polypeptide binding]; other site 1095774004552 catalytic residues [active] 1095774004553 active site lid [active] 1095774004554 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1095774004555 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1095774004556 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1095774004557 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1095774004558 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1095774004559 putative active site [active] 1095774004560 hypothetical protein; Provisional; Region: PRK11590 1095774004561 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1095774004562 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1095774004563 nucleoside/Zn binding site; other site 1095774004564 dimer interface [polypeptide binding]; other site 1095774004565 catalytic motif [active] 1095774004566 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1095774004567 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774004568 substrate binding pocket [chemical binding]; other site 1095774004569 membrane-bound complex binding site; other site 1095774004570 hinge residues; other site 1095774004571 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1095774004572 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1095774004573 catalytic residue [active] 1095774004574 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1095774004575 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1095774004576 dimerization interface [polypeptide binding]; other site 1095774004577 ATP binding site [chemical binding]; other site 1095774004578 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1095774004579 dimerization interface [polypeptide binding]; other site 1095774004580 ATP binding site [chemical binding]; other site 1095774004581 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1095774004582 putative active site [active] 1095774004583 catalytic triad [active] 1095774004584 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1095774004585 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1095774004586 dimer interface [polypeptide binding]; other site 1095774004587 phosphorylation site [posttranslational modification] 1095774004588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774004589 ATP binding site [chemical binding]; other site 1095774004590 Mg2+ binding site [ion binding]; other site 1095774004591 G-X-G motif; other site 1095774004592 hypothetical protein; Provisional; Region: PRK10722 1095774004593 response regulator GlrR; Provisional; Region: PRK15115 1095774004594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774004595 active site 1095774004596 phosphorylation site [posttranslational modification] 1095774004597 intermolecular recognition site; other site 1095774004598 dimerization interface [polypeptide binding]; other site 1095774004599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774004600 Walker A motif; other site 1095774004601 ATP binding site [chemical binding]; other site 1095774004602 Walker B motif; other site 1095774004603 arginine finger; other site 1095774004604 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1095774004605 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1095774004606 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1095774004607 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1095774004608 heme-binding site [chemical binding]; other site 1095774004609 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1095774004610 FAD binding pocket [chemical binding]; other site 1095774004611 FAD binding motif [chemical binding]; other site 1095774004612 phosphate binding motif [ion binding]; other site 1095774004613 beta-alpha-beta structure motif; other site 1095774004614 NAD binding pocket [chemical binding]; other site 1095774004615 Heme binding pocket [chemical binding]; other site 1095774004616 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1095774004617 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1095774004618 dimer interface [polypeptide binding]; other site 1095774004619 active site 1095774004620 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1095774004621 folate binding site [chemical binding]; other site 1095774004622 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1095774004623 MFS_1 like family; Region: MFS_1_like; pfam12832 1095774004624 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 1095774004625 PRD domain; Region: PRD; pfam00874 1095774004626 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 1095774004627 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1095774004628 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 1095774004629 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1095774004630 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1095774004631 active site 1095774004632 dimerization interface [polypeptide binding]; other site 1095774004633 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1095774004634 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1095774004635 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 1095774004636 Rrf2 family protein; Region: rrf2_super; TIGR00738 1095774004637 cysteine desulfurase; Provisional; Region: PRK14012 1095774004638 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1095774004639 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1095774004640 catalytic residue [active] 1095774004641 aminopeptidase B; Provisional; Region: PRK05015 1095774004642 Peptidase; Region: DUF3663; pfam12404 1095774004643 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1095774004644 interface (dimer of trimers) [polypeptide binding]; other site 1095774004645 Substrate-binding/catalytic site; other site 1095774004646 Zn-binding sites [ion binding]; other site 1095774004647 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 1095774004648 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1095774004649 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1095774004650 active site residue [active] 1095774004651 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1095774004652 active site residue [active] 1095774004653 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1095774004654 MG2 domain; Region: A2M_N; pfam01835 1095774004655 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1095774004656 surface patch; other site 1095774004657 thioester region; other site 1095774004658 penicillin-binding protein 1C; Provisional; Region: PRK11240 1095774004659 Transglycosylase; Region: Transgly; pfam00912 1095774004660 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1095774004661 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1095774004662 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1095774004663 active site 1095774004664 multimer interface [polypeptide binding]; other site 1095774004665 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1095774004666 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1095774004667 FeS/SAM binding site; other site 1095774004668 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 1095774004669 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1095774004670 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1095774004671 non-specific DNA binding site [nucleotide binding]; other site 1095774004672 salt bridge; other site 1095774004673 sequence-specific DNA binding site [nucleotide binding]; other site 1095774004674 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1095774004675 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1095774004676 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1095774004677 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1095774004678 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1095774004679 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1095774004680 dimer interface [polypeptide binding]; other site 1095774004681 motif 1; other site 1095774004682 active site 1095774004683 motif 2; other site 1095774004684 motif 3; other site 1095774004685 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1095774004686 anticodon binding site; other site 1095774004687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1095774004688 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1095774004689 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1095774004690 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 1095774004691 Trp docking motif [polypeptide binding]; other site 1095774004692 GTP-binding protein Der; Reviewed; Region: PRK00093 1095774004693 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1095774004694 G1 box; other site 1095774004695 GTP/Mg2+ binding site [chemical binding]; other site 1095774004696 Switch I region; other site 1095774004697 G2 box; other site 1095774004698 Switch II region; other site 1095774004699 G3 box; other site 1095774004700 G4 box; other site 1095774004701 G5 box; other site 1095774004702 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1095774004703 G1 box; other site 1095774004704 GTP/Mg2+ binding site [chemical binding]; other site 1095774004705 Switch I region; other site 1095774004706 G2 box; other site 1095774004707 G3 box; other site 1095774004708 Switch II region; other site 1095774004709 G4 box; other site 1095774004710 G5 box; other site 1095774004711 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1095774004712 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1095774004713 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1095774004714 Trp docking motif [polypeptide binding]; other site 1095774004715 putative active site [active] 1095774004716 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1095774004717 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1095774004718 active site 1095774004719 Zn binding site [ion binding]; other site 1095774004720 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1095774004721 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1095774004722 generic binding surface II; other site 1095774004723 generic binding surface I; other site 1095774004724 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1095774004725 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1095774004726 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1095774004727 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1095774004728 active site 1095774004729 GMP synthase; Reviewed; Region: guaA; PRK00074 1095774004730 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1095774004731 AMP/PPi binding site [chemical binding]; other site 1095774004732 candidate oxyanion hole; other site 1095774004733 catalytic triad [active] 1095774004734 potential glutamine specificity residues [chemical binding]; other site 1095774004735 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1095774004736 ATP Binding subdomain [chemical binding]; other site 1095774004737 Ligand Binding sites [chemical binding]; other site 1095774004738 Dimerization subdomain; other site 1095774004739 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1095774004740 EamA-like transporter family; Region: EamA; pfam00892 1095774004741 EamA-like transporter family; Region: EamA; pfam00892 1095774004742 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1095774004743 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1095774004744 substrate binding pocket [chemical binding]; other site 1095774004745 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1095774004746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1095774004747 TPR motif; other site 1095774004748 binding surface 1095774004749 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 1095774004750 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 1095774004751 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1095774004752 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1095774004753 MgtE intracellular N domain; Region: MgtE_N; smart00924 1095774004754 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1095774004755 Divalent cation transporter; Region: MgtE; cl00786 1095774004756 tellurite resistance protein TehB; Provisional; Region: PRK11207 1095774004757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774004758 S-adenosylmethionine binding site [chemical binding]; other site 1095774004759 exopolyphosphatase; Provisional; Region: PRK10854 1095774004760 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1095774004761 nucleotide binding site [chemical binding]; other site 1095774004762 polyphosphate kinase; Provisional; Region: PRK05443 1095774004763 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1095774004764 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1095774004765 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 1095774004766 domain interface [polypeptide binding]; other site 1095774004767 active site 1095774004768 catalytic site [active] 1095774004769 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 1095774004770 domain interface [polypeptide binding]; other site 1095774004771 active site 1095774004772 catalytic site [active] 1095774004773 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 1095774004774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774004775 ABC-ATPase subunit interface; other site 1095774004776 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 1095774004777 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1095774004778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774004779 ABC-ATPase subunit interface; other site 1095774004780 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 1095774004781 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1095774004782 Walker A/P-loop; other site 1095774004783 ATP binding site [chemical binding]; other site 1095774004784 Q-loop/lid; other site 1095774004785 ABC transporter signature motif; other site 1095774004786 Walker B; other site 1095774004787 D-loop; other site 1095774004788 H-loop/switch region; other site 1095774004789 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1095774004790 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1095774004791 active site 1095774004792 substrate binding site [chemical binding]; other site 1095774004793 cosubstrate binding site; other site 1095774004794 catalytic site [active] 1095774004795 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1095774004796 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1095774004797 dimerization interface [polypeptide binding]; other site 1095774004798 putative ATP binding site [chemical binding]; other site 1095774004799 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1095774004800 active site 1095774004801 uracil transporter; Provisional; Region: PRK10720 1095774004802 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1095774004803 DNA replication initiation factor; Provisional; Region: PRK08084 1095774004804 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1095774004805 ArsC family; Region: ArsC; pfam03960 1095774004806 catalytic residues [active] 1095774004807 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1095774004808 Peptidase family M48; Region: Peptidase_M48; pfam01435 1095774004809 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1095774004810 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774004811 DNA binding site [nucleotide binding] 1095774004812 domain linker motif; other site 1095774004813 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1095774004814 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1095774004815 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1095774004816 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1095774004817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774004818 dimer interface [polypeptide binding]; other site 1095774004819 conserved gate region; other site 1095774004820 putative PBP binding loops; other site 1095774004821 ABC-ATPase subunit interface; other site 1095774004822 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1095774004823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774004824 dimer interface [polypeptide binding]; other site 1095774004825 conserved gate region; other site 1095774004826 putative PBP binding loops; other site 1095774004827 ABC-ATPase subunit interface; other site 1095774004828 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1095774004829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774004830 Walker A/P-loop; other site 1095774004831 ATP binding site [chemical binding]; other site 1095774004832 Q-loop/lid; other site 1095774004833 ABC transporter signature motif; other site 1095774004834 Walker B; other site 1095774004835 D-loop; other site 1095774004836 H-loop/switch region; other site 1095774004837 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1095774004838 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1095774004839 active site 1095774004840 metal binding site [ion binding]; metal-binding site 1095774004841 hexamer interface [polypeptide binding]; other site 1095774004842 Cache domain; Region: Cache_1; pfam02743 1095774004843 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1095774004844 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1095774004845 metal binding site [ion binding]; metal-binding site 1095774004846 active site 1095774004847 I-site; other site 1095774004848 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1095774004849 Helix-turn-helix domain; Region: HTH_18; pfam12833 1095774004850 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774004851 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1095774004852 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1095774004853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1095774004854 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1095774004855 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1095774004856 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1095774004857 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1095774004858 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1095774004859 catalytic triad [active] 1095774004860 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1095774004861 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1095774004862 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1095774004863 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1095774004864 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1095774004865 dimer interface [polypeptide binding]; other site 1095774004866 active site 1095774004867 catalytic residue [active] 1095774004868 lipoprotein; Provisional; Region: PRK11679 1095774004869 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1095774004870 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1095774004871 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1095774004872 ATP binding site [chemical binding]; other site 1095774004873 active site 1095774004874 substrate binding site [chemical binding]; other site 1095774004875 Predicted metalloprotease [General function prediction only]; Region: COG2321 1095774004876 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1095774004877 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1095774004878 Helicase; Region: Helicase_RecD; pfam05127 1095774004879 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1095774004880 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1095774004881 putative hydrolase; Provisional; Region: PRK11460 1095774004882 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1095774004883 hypothetical protein; Provisional; Region: PRK13664 1095774004884 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1095774004885 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1095774004886 metal binding site [ion binding]; metal-binding site 1095774004887 dimer interface [polypeptide binding]; other site 1095774004888 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1095774004889 ArsC family; Region: ArsC; pfam03960 1095774004890 putative catalytic residues [active] 1095774004891 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1095774004892 Protein export membrane protein; Region: SecD_SecF; cl14618 1095774004893 transcriptional regulator NarP; Provisional; Region: PRK10403 1095774004894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774004895 active site 1095774004896 phosphorylation site [posttranslational modification] 1095774004897 intermolecular recognition site; other site 1095774004898 dimerization interface [polypeptide binding]; other site 1095774004899 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1095774004900 DNA binding residues [nucleotide binding] 1095774004901 dimerization interface [polypeptide binding]; other site 1095774004902 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 1095774004903 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1095774004904 HAMP domain; Region: HAMP; pfam00672 1095774004905 Histidine kinase; Region: HisKA_3; pfam07730 1095774004906 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774004907 ATP binding site [chemical binding]; other site 1095774004908 Mg2+ binding site [ion binding]; other site 1095774004909 G-X-G motif; other site 1095774004910 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1095774004911 L-asparagine permease; Provisional; Region: PRK15049 1095774004912 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1095774004913 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1095774004914 dimer interface [polypeptide binding]; other site 1095774004915 ADP-ribose binding site [chemical binding]; other site 1095774004916 active site 1095774004917 nudix motif; other site 1095774004918 metal binding site [ion binding]; metal-binding site 1095774004919 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1095774004920 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1095774004921 substrate binding site [chemical binding]; other site 1095774004922 dimer interface [polypeptide binding]; other site 1095774004923 ATP binding site [chemical binding]; other site 1095774004924 D-allose kinase; Provisional; Region: PRK09698 1095774004925 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1095774004926 nucleotide binding site [chemical binding]; other site 1095774004927 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1095774004928 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1095774004929 substrate binding site [chemical binding]; other site 1095774004930 hexamer interface [polypeptide binding]; other site 1095774004931 metal binding site [ion binding]; metal-binding site 1095774004932 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1095774004933 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1095774004934 TM-ABC transporter signature motif; other site 1095774004935 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1095774004936 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1095774004937 TM-ABC transporter signature motif; other site 1095774004938 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1095774004939 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1095774004940 Walker A/P-loop; other site 1095774004941 ATP binding site [chemical binding]; other site 1095774004942 Q-loop/lid; other site 1095774004943 ABC transporter signature motif; other site 1095774004944 Walker B; other site 1095774004945 D-loop; other site 1095774004946 H-loop/switch region; other site 1095774004947 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1095774004948 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1095774004949 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1095774004950 ligand binding site [chemical binding]; other site 1095774004951 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1095774004952 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1095774004953 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1095774004954 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1095774004955 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 1095774004956 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1095774004957 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1095774004958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774004959 active site 1095774004960 phosphorylation site [posttranslational modification] 1095774004961 intermolecular recognition site; other site 1095774004962 dimerization interface [polypeptide binding]; other site 1095774004963 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1095774004964 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1095774004965 putative active site [active] 1095774004966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774004967 ATP binding site [chemical binding]; other site 1095774004968 Mg2+ binding site [ion binding]; other site 1095774004969 G-X-G motif; other site 1095774004970 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1095774004971 transketolase; Reviewed; Region: PRK12753 1095774004972 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1095774004973 TPP-binding site [chemical binding]; other site 1095774004974 dimer interface [polypeptide binding]; other site 1095774004975 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1095774004976 PYR/PP interface [polypeptide binding]; other site 1095774004977 dimer interface [polypeptide binding]; other site 1095774004978 TPP binding site [chemical binding]; other site 1095774004979 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1095774004980 transaldolase-like protein; Provisional; Region: PTZ00411 1095774004981 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1095774004982 active site 1095774004983 dimer interface [polypeptide binding]; other site 1095774004984 catalytic residue [active] 1095774004985 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1095774004986 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1095774004987 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1095774004988 putative NAD(P) binding site [chemical binding]; other site 1095774004989 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1095774004990 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1095774004991 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1095774004992 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1095774004993 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1095774004994 active site 1095774004995 metal binding site [ion binding]; metal-binding site 1095774004996 putative acetyltransferase; Provisional; Region: PRK03624 1095774004997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774004998 Coenzyme A binding pocket [chemical binding]; other site 1095774004999 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1095774005000 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1095774005001 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 1095774005002 thiosulfate transporter subunit; Provisional; Region: PRK10852 1095774005003 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1095774005004 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1095774005005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774005006 dimer interface [polypeptide binding]; other site 1095774005007 conserved gate region; other site 1095774005008 putative PBP binding loops; other site 1095774005009 ABC-ATPase subunit interface; other site 1095774005010 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1095774005011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774005012 dimer interface [polypeptide binding]; other site 1095774005013 conserved gate region; other site 1095774005014 putative PBP binding loops; other site 1095774005015 ABC-ATPase subunit interface; other site 1095774005016 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1095774005017 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1095774005018 Walker A/P-loop; other site 1095774005019 ATP binding site [chemical binding]; other site 1095774005020 Q-loop/lid; other site 1095774005021 ABC transporter signature motif; other site 1095774005022 Walker B; other site 1095774005023 D-loop; other site 1095774005024 H-loop/switch region; other site 1095774005025 TOBE-like domain; Region: TOBE_3; pfam12857 1095774005026 cysteine synthase B; Region: cysM; TIGR01138 1095774005027 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1095774005028 dimer interface [polypeptide binding]; other site 1095774005029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774005030 catalytic residue [active] 1095774005031 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1095774005032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774005033 active site 1095774005034 phosphorylation site [posttranslational modification] 1095774005035 intermolecular recognition site; other site 1095774005036 dimerization interface [polypeptide binding]; other site 1095774005037 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1095774005038 DNA binding site [nucleotide binding] 1095774005039 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774005040 dimerization interface [polypeptide binding]; other site 1095774005041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1095774005042 dimer interface [polypeptide binding]; other site 1095774005043 phosphorylation site [posttranslational modification] 1095774005044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774005045 ATP binding site [chemical binding]; other site 1095774005046 Mg2+ binding site [ion binding]; other site 1095774005047 G-X-G motif; other site 1095774005048 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1095774005049 HPr interaction site; other site 1095774005050 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1095774005051 active site 1095774005052 phosphorylation site [posttranslational modification] 1095774005053 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1095774005054 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1095774005055 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1095774005056 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1095774005057 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1095774005058 dimerization domain swap beta strand [polypeptide binding]; other site 1095774005059 regulatory protein interface [polypeptide binding]; other site 1095774005060 active site 1095774005061 regulatory phosphorylation site [posttranslational modification]; other site 1095774005062 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1095774005063 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1095774005064 dimer interface [polypeptide binding]; other site 1095774005065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774005066 catalytic residue [active] 1095774005067 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1095774005068 cell division protein ZipA; Provisional; Region: PRK03427 1095774005069 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1095774005070 FtsZ protein binding site [polypeptide binding]; other site 1095774005071 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1095774005072 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1095774005073 nucleotide binding pocket [chemical binding]; other site 1095774005074 K-X-D-G motif; other site 1095774005075 catalytic site [active] 1095774005076 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1095774005077 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1095774005078 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1095774005079 Dimer interface [polypeptide binding]; other site 1095774005080 BRCT sequence motif; other site 1095774005081 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 1095774005082 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1095774005083 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1095774005084 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774005085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774005086 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1095774005087 putative dimerization interface [polypeptide binding]; other site 1095774005088 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1095774005089 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1095774005090 active site 1095774005091 HIGH motif; other site 1095774005092 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1095774005093 active site 1095774005094 KMSKS motif; other site 1095774005095 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1095774005096 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1095774005097 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1095774005098 metal binding triad [ion binding]; metal-binding site 1095774005099 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1095774005100 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1095774005101 Nucleoside recognition; Region: Gate; pfam07670 1095774005102 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1095774005103 manganese transport protein MntH; Reviewed; Region: PRK00701 1095774005104 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1095774005105 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1095774005106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774005107 S-adenosylmethionine binding site [chemical binding]; other site 1095774005108 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1095774005109 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1095774005110 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1095774005111 active site 1095774005112 catalytic tetrad [active] 1095774005113 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 1095774005114 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1095774005115 dimer interface [polypeptide binding]; other site 1095774005116 PYR/PP interface [polypeptide binding]; other site 1095774005117 TPP binding site [chemical binding]; other site 1095774005118 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1095774005119 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1095774005120 TPP-binding site [chemical binding]; other site 1095774005121 dimer interface [polypeptide binding]; other site 1095774005122 glucokinase, proteobacterial type; Region: glk; TIGR00749 1095774005123 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1095774005124 nucleotide binding site [chemical binding]; other site 1095774005125 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1095774005126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774005127 active site 1095774005128 phosphorylation site [posttranslational modification] 1095774005129 intermolecular recognition site; other site 1095774005130 dimerization interface [polypeptide binding]; other site 1095774005131 LytTr DNA-binding domain; Region: LytTR; pfam04397 1095774005132 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1095774005133 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1095774005134 GAF domain; Region: GAF_3; pfam13492 1095774005135 Histidine kinase; Region: His_kinase; pfam06580 1095774005136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774005137 ATP binding site [chemical binding]; other site 1095774005138 Mg2+ binding site [ion binding]; other site 1095774005139 G-X-G motif; other site 1095774005140 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1095774005141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774005142 Coenzyme A binding pocket [chemical binding]; other site 1095774005143 aminotransferase; Validated; Region: PRK08175 1095774005144 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1095774005145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774005146 homodimer interface [polypeptide binding]; other site 1095774005147 catalytic residue [active] 1095774005148 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1095774005149 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1095774005150 HlyD family secretion protein; Region: HlyD_3; pfam13437 1095774005151 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1095774005152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774005153 putative substrate translocation pore; other site 1095774005154 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1095774005155 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1095774005156 Bacterial transcriptional regulator; Region: IclR; pfam01614 1095774005157 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1095774005158 Ligand Binding Site [chemical binding]; other site 1095774005159 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1095774005160 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1095774005161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774005162 putative substrate translocation pore; other site 1095774005163 Secretin and TonB N terminus short domain; Region: STN; smart00965 1095774005164 RES domain; Region: RES; cl02411 1095774005165 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1095774005166 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1095774005167 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1095774005168 PapC N-terminal domain; Region: PapC_N; pfam13954 1095774005169 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1095774005170 PapC C-terminal domain; Region: PapC_C; pfam13953 1095774005171 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1095774005172 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1095774005173 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1095774005174 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1095774005175 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1095774005176 FaeA-like protein; Region: FaeA; pfam04703 1095774005177 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 1095774005178 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1095774005179 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1095774005180 Fimbrial protein; Region: Fimbrial; pfam00419 1095774005181 Fimbrial protein; Region: Fimbrial; pfam00419 1095774005182 Fimbrial protein; Region: Fimbrial; cl01416 1095774005183 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1095774005184 MarR family; Region: MarR_2; pfam12802 1095774005185 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1095774005186 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1095774005187 nucleotide binding site [chemical binding]; other site 1095774005188 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1095774005189 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1095774005190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774005191 dimer interface [polypeptide binding]; other site 1095774005192 conserved gate region; other site 1095774005193 putative PBP binding loops; other site 1095774005194 ABC-ATPase subunit interface; other site 1095774005195 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1095774005196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774005197 dimer interface [polypeptide binding]; other site 1095774005198 conserved gate region; other site 1095774005199 putative PBP binding loops; other site 1095774005200 ABC-ATPase subunit interface; other site 1095774005201 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1095774005202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774005203 Walker A/P-loop; other site 1095774005204 ATP binding site [chemical binding]; other site 1095774005205 Q-loop/lid; other site 1095774005206 ABC transporter signature motif; other site 1095774005207 Walker B; other site 1095774005208 D-loop; other site 1095774005209 H-loop/switch region; other site 1095774005210 TOBE domain; Region: TOBE_2; pfam08402 1095774005211 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1095774005212 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 1095774005213 putative active site [active] 1095774005214 catalytic site [active] 1095774005215 putative metal binding site [ion binding]; other site 1095774005216 oligomer interface [polypeptide binding]; other site 1095774005217 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1095774005218 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1095774005219 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 1095774005220 Walker A/P-loop; other site 1095774005221 ATP binding site [chemical binding]; other site 1095774005222 Q-loop/lid; other site 1095774005223 ABC transporter signature motif; other site 1095774005224 Walker B; other site 1095774005225 D-loop; other site 1095774005226 H-loop/switch region; other site 1095774005227 heme exporter protein CcmB; Region: ccmB; TIGR01190 1095774005228 heme exporter protein CcmC; Region: ccmC; TIGR01191 1095774005229 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1095774005230 CcmE; Region: CcmE; cl00994 1095774005231 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 1095774005232 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1095774005233 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1095774005234 catalytic residues [active] 1095774005235 central insert; other site 1095774005236 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1095774005237 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1095774005238 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1095774005239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1095774005240 binding surface 1095774005241 TPR motif; other site 1095774005242 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1095774005243 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1095774005244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1095774005245 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1095774005246 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1095774005247 dimer interface [polypeptide binding]; other site 1095774005248 active site 1095774005249 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1095774005250 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1095774005251 substrate binding site [chemical binding]; other site 1095774005252 oxyanion hole (OAH) forming residues; other site 1095774005253 trimer interface [polypeptide binding]; other site 1095774005254 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1095774005255 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1095774005256 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1095774005257 catalytic core [active] 1095774005258 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774005259 dimerization interface [polypeptide binding]; other site 1095774005260 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1095774005261 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774005262 dimer interface [polypeptide binding]; other site 1095774005263 putative CheW interface [polypeptide binding]; other site 1095774005264 hypothetical protein; Provisional; Region: PRK04946 1095774005265 Smr domain; Region: Smr; pfam01713 1095774005266 HemK family putative methylases; Region: hemK_fam; TIGR00536 1095774005267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774005268 S-adenosylmethionine binding site [chemical binding]; other site 1095774005269 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1095774005270 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1095774005271 Tetramer interface [polypeptide binding]; other site 1095774005272 active site 1095774005273 FMN-binding site [chemical binding]; other site 1095774005274 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1095774005275 hypothetical protein; Provisional; Region: PRK10621 1095774005276 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1095774005277 Protein of unknown function, DUF462; Region: DUF462; cl01190 1095774005278 YfcL protein; Region: YfcL; pfam08891 1095774005279 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1095774005280 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1095774005281 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1095774005282 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1095774005283 dimer interface [polypeptide binding]; other site 1095774005284 active site 1095774005285 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1095774005286 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774005287 DNA-binding site [nucleotide binding]; DNA binding site 1095774005288 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1095774005289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774005290 homodimer interface [polypeptide binding]; other site 1095774005291 catalytic residue [active] 1095774005292 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 1095774005293 active site residue [active] 1095774005294 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1095774005295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1095774005296 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1095774005297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1095774005298 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1095774005299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774005300 active site 1095774005301 phosphorylation site [posttranslational modification] 1095774005302 intermolecular recognition site; other site 1095774005303 dimerization interface [polypeptide binding]; other site 1095774005304 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1095774005305 DNA binding site [nucleotide binding] 1095774005306 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1095774005307 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1095774005308 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1095774005309 dimer interface [polypeptide binding]; other site 1095774005310 phosphorylation site [posttranslational modification] 1095774005311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774005312 ATP binding site [chemical binding]; other site 1095774005313 Mg2+ binding site [ion binding]; other site 1095774005314 G-X-G motif; other site 1095774005315 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1095774005316 EamA-like transporter family; Region: EamA; pfam00892 1095774005317 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1095774005318 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1095774005319 ligand binding site [chemical binding]; other site 1095774005320 NAD binding site [chemical binding]; other site 1095774005321 catalytic site [active] 1095774005322 homodimer interface [polypeptide binding]; other site 1095774005323 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1095774005324 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1095774005325 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1095774005326 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1095774005327 dimerization interface 3.5A [polypeptide binding]; other site 1095774005328 active site 1095774005329 hypothetical protein; Provisional; Region: PRK10847 1095774005330 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1095774005331 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1095774005332 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1095774005333 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1095774005334 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1095774005335 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1095774005336 cell division protein DedD; Provisional; Region: PRK11633 1095774005337 Sporulation related domain; Region: SPOR; pfam05036 1095774005338 colicin V production protein; Provisional; Region: PRK10845 1095774005339 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1095774005340 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1095774005341 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1095774005342 active site 1095774005343 tetramer interface [polypeptide binding]; other site 1095774005344 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1095774005345 active site 1095774005346 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1095774005347 Flavoprotein; Region: Flavoprotein; pfam02441 1095774005348 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1095774005349 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774005350 substrate binding pocket [chemical binding]; other site 1095774005351 membrane-bound complex binding site; other site 1095774005352 hinge residues; other site 1095774005353 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1095774005354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774005355 dimer interface [polypeptide binding]; other site 1095774005356 conserved gate region; other site 1095774005357 putative PBP binding loops; other site 1095774005358 ABC-ATPase subunit interface; other site 1095774005359 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1095774005360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774005361 dimer interface [polypeptide binding]; other site 1095774005362 conserved gate region; other site 1095774005363 putative PBP binding loops; other site 1095774005364 ABC-ATPase subunit interface; other site 1095774005365 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1095774005366 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1095774005367 Walker A/P-loop; other site 1095774005368 ATP binding site [chemical binding]; other site 1095774005369 Q-loop/lid; other site 1095774005370 ABC transporter signature motif; other site 1095774005371 Walker B; other site 1095774005372 D-loop; other site 1095774005373 H-loop/switch region; other site 1095774005374 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1095774005375 MarR family; Region: MarR_2; pfam12802 1095774005376 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1095774005377 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1095774005378 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1095774005379 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1095774005380 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1095774005381 N- and C-terminal domain interface [polypeptide binding]; other site 1095774005382 D-xylulose kinase; Region: XylB; TIGR01312 1095774005383 active site 1095774005384 MgATP binding site [chemical binding]; other site 1095774005385 catalytic site [active] 1095774005386 metal binding site [ion binding]; metal-binding site 1095774005387 xylulose binding site [chemical binding]; other site 1095774005388 homodimer interface [polypeptide binding]; other site 1095774005389 polyol permease family; Region: 2A0118; TIGR00897 1095774005390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774005391 putative substrate translocation pore; other site 1095774005392 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1095774005393 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1095774005394 putative NAD(P) binding site [chemical binding]; other site 1095774005395 putative active site [active] 1095774005396 glutathione S-transferase; Provisional; Region: PRK15113 1095774005397 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1095774005398 C-terminal domain interface [polypeptide binding]; other site 1095774005399 GSH binding site (G-site) [chemical binding]; other site 1095774005400 dimer interface [polypeptide binding]; other site 1095774005401 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1095774005402 N-terminal domain interface [polypeptide binding]; other site 1095774005403 putative dimer interface [polypeptide binding]; other site 1095774005404 putative substrate binding pocket (H-site) [chemical binding]; other site 1095774005405 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1095774005406 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1095774005407 nudix motif; other site 1095774005408 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1095774005409 salt bridge; other site 1095774005410 non-specific DNA binding site [nucleotide binding]; other site 1095774005411 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1095774005412 sequence-specific DNA binding site [nucleotide binding]; other site 1095774005413 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1095774005414 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 1095774005415 NAD(P) binding site [chemical binding]; other site 1095774005416 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1095774005417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774005418 dimer interface [polypeptide binding]; other site 1095774005419 conserved gate region; other site 1095774005420 putative PBP binding loops; other site 1095774005421 ABC-ATPase subunit interface; other site 1095774005422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774005423 dimer interface [polypeptide binding]; other site 1095774005424 conserved gate region; other site 1095774005425 putative PBP binding loops; other site 1095774005426 ABC-ATPase subunit interface; other site 1095774005427 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1095774005428 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1095774005429 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 1095774005430 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1095774005431 inhibitor-cofactor binding pocket; inhibition site 1095774005432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774005433 catalytic residue [active] 1095774005434 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1095774005435 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774005436 DNA-binding site [nucleotide binding]; DNA binding site 1095774005437 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1095774005438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774005439 homodimer interface [polypeptide binding]; other site 1095774005440 catalytic residue [active] 1095774005441 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1095774005442 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1095774005443 Walker A/P-loop; other site 1095774005444 ATP binding site [chemical binding]; other site 1095774005445 Q-loop/lid; other site 1095774005446 ABC transporter signature motif; other site 1095774005447 Walker B; other site 1095774005448 D-loop; other site 1095774005449 H-loop/switch region; other site 1095774005450 TOBE domain; Region: TOBE_2; pfam08402 1095774005451 phosphate acetyltransferase; Reviewed; Region: PRK05632 1095774005452 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1095774005453 DRTGG domain; Region: DRTGG; pfam07085 1095774005454 phosphate acetyltransferase; Region: pta; TIGR00651 1095774005455 propionate/acetate kinase; Provisional; Region: PRK12379 1095774005456 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1095774005457 hypothetical protein; Provisional; Region: PRK01816 1095774005458 hypothetical protein; Validated; Region: PRK05445 1095774005459 putative phosphatase; Provisional; Region: PRK11587 1095774005460 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774005461 motif II; other site 1095774005462 5'-nucleotidase; Provisional; Region: PRK03826 1095774005463 aminotransferase AlaT; Validated; Region: PRK09265 1095774005464 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1095774005465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774005466 homodimer interface [polypeptide binding]; other site 1095774005467 catalytic residue [active] 1095774005468 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1095774005469 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774005470 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1095774005471 putative dimerization interface [polypeptide binding]; other site 1095774005472 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1095774005473 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1095774005474 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1095774005475 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1095774005476 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1095774005477 NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905 1095774005478 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1095774005479 putative dimer interface [polypeptide binding]; other site 1095774005480 [2Fe-2S] cluster binding site [ion binding]; other site 1095774005481 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1095774005482 SLBB domain; Region: SLBB; pfam10531 1095774005483 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1095774005484 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1095774005485 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1095774005486 catalytic loop [active] 1095774005487 iron binding site [ion binding]; other site 1095774005488 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1095774005489 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1095774005490 [4Fe-4S] binding site [ion binding]; other site 1095774005491 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1095774005492 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1095774005493 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1095774005494 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1095774005495 4Fe-4S binding domain; Region: Fer4; pfam00037 1095774005496 4Fe-4S binding domain; Region: Fer4; pfam00037 1095774005497 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 1095774005498 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1095774005499 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1095774005500 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1095774005501 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1095774005502 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1095774005503 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1095774005504 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1095774005505 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1095774005506 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1095774005507 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1095774005508 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1095774005509 Predicted acyltransferase [General function prediction only]; Region: ElaA; COG2153 1095774005510 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1095774005511 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1095774005512 hypothetical protein; Provisional; Region: PRK10404 1095774005513 hypothetical protein; Provisional; Region: PRK03673 1095774005514 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1095774005515 putative MPT binding site; other site 1095774005516 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1095774005517 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1095774005518 catalytic loop [active] 1095774005519 iron binding site [ion binding]; other site 1095774005520 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1095774005521 dimer interface [polypeptide binding]; other site 1095774005522 putative radical transfer pathway; other site 1095774005523 diiron center [ion binding]; other site 1095774005524 tyrosyl radical; other site 1095774005525 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1095774005526 ATP cone domain; Region: ATP-cone; pfam03477 1095774005527 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1095774005528 active site 1095774005529 dimer interface [polypeptide binding]; other site 1095774005530 catalytic residues [active] 1095774005531 effector binding site; other site 1095774005532 R2 peptide binding site; other site 1095774005533 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1095774005534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774005535 S-adenosylmethionine binding site [chemical binding]; other site 1095774005536 DNA gyrase subunit A; Validated; Region: PRK05560 1095774005537 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1095774005538 CAP-like domain; other site 1095774005539 active site 1095774005540 primary dimer interface [polypeptide binding]; other site 1095774005541 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1095774005542 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1095774005543 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1095774005544 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1095774005545 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1095774005546 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1095774005547 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 1095774005548 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1095774005549 dimer interface [polypeptide binding]; other site 1095774005550 phosphorylation site [posttranslational modification] 1095774005551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774005552 ATP binding site [chemical binding]; other site 1095774005553 Mg2+ binding site [ion binding]; other site 1095774005554 G-X-G motif; other site 1095774005555 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 1095774005556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774005557 active site 1095774005558 phosphorylation site [posttranslational modification] 1095774005559 intermolecular recognition site; other site 1095774005560 dimerization interface [polypeptide binding]; other site 1095774005561 transcriptional regulator RcsB; Provisional; Region: PRK10840 1095774005562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774005563 active site 1095774005564 phosphorylation site [posttranslational modification] 1095774005565 intermolecular recognition site; other site 1095774005566 dimerization interface [polypeptide binding]; other site 1095774005567 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1095774005568 DNA binding residues [nucleotide binding] 1095774005569 dimerization interface [polypeptide binding]; other site 1095774005570 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1095774005571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774005572 ATP binding site [chemical binding]; other site 1095774005573 Mg2+ binding site [ion binding]; other site 1095774005574 G-X-G motif; other site 1095774005575 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1095774005576 putative binding surface; other site 1095774005577 active site 1095774005578 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1095774005579 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1095774005580 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1095774005581 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1095774005582 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1095774005583 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1095774005584 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1095774005585 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1095774005586 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1095774005587 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1095774005588 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1095774005589 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1095774005590 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1095774005591 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1095774005592 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1095774005593 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1095774005594 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1095774005595 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1095774005596 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1095774005597 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 1095774005598 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1095774005599 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1095774005600 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1095774005601 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 1095774005602 Walker A/P-loop; other site 1095774005603 ATP binding site [chemical binding]; other site 1095774005604 Q-loop/lid; other site 1095774005605 ABC transporter signature motif; other site 1095774005606 Walker B; other site 1095774005607 D-loop; other site 1095774005608 H-loop/switch region; other site 1095774005609 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1095774005610 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1095774005611 HlyD family secretion protein; Region: HlyD_3; pfam13437 1095774005612 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1095774005613 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1095774005614 trimer interface [polypeptide binding]; other site 1095774005615 eyelet of channel; other site 1095774005616 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1095774005617 ApbE family; Region: ApbE; pfam02424 1095774005618 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1095774005619 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1095774005620 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1095774005621 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1095774005622 Walker A/P-loop; other site 1095774005623 ATP binding site [chemical binding]; other site 1095774005624 Q-loop/lid; other site 1095774005625 ABC transporter signature motif; other site 1095774005626 Walker B; other site 1095774005627 D-loop; other site 1095774005628 H-loop/switch region; other site 1095774005629 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1095774005630 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1095774005631 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1095774005632 MFS/sugar transport protein; Region: MFS_2; pfam13347 1095774005633 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1095774005634 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1095774005635 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1095774005636 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1095774005637 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1095774005638 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1095774005639 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1095774005640 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1095774005641 FecR protein; Region: FecR; pfam04773 1095774005642 RNA polymerase sigma factor; Provisional; Region: PRK12525 1095774005643 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1095774005644 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1095774005645 DNA binding residues [nucleotide binding] 1095774005646 Secretin and TonB N terminus short domain; Region: STN; smart00965 1095774005647 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1095774005648 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1095774005649 N-terminal plug; other site 1095774005650 ligand-binding site [chemical binding]; other site 1095774005651 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1095774005652 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1095774005653 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1095774005654 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1095774005655 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1095774005656 catalytic residues [active] 1095774005657 peptidase PmbA; Provisional; Region: PRK11040 1095774005658 protease TldD; Provisional; Region: tldD; PRK10735 1095774005659 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 1095774005660 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1095774005661 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1095774005662 Sulfatase; Region: Sulfatase; cl17466 1095774005663 hypothetical protein; Provisional; Region: PRK13689 1095774005664 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1095774005665 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1095774005666 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1095774005667 5S rRNA interface [nucleotide binding]; other site 1095774005668 CTC domain interface [polypeptide binding]; other site 1095774005669 L16 interface [polypeptide binding]; other site 1095774005670 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1095774005671 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1095774005672 ATP binding site [chemical binding]; other site 1095774005673 putative Mg++ binding site [ion binding]; other site 1095774005674 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1095774005675 nucleotide binding region [chemical binding]; other site 1095774005676 ATP-binding site [chemical binding]; other site 1095774005677 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1095774005678 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1095774005679 RNA binding surface [nucleotide binding]; other site 1095774005680 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1095774005681 active site 1095774005682 uracil binding [chemical binding]; other site 1095774005683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774005684 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1095774005685 putative substrate translocation pore; other site 1095774005686 YejG-like protein; Region: YejG; pfam13989 1095774005687 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 1095774005688 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1095774005689 Walker A/P-loop; other site 1095774005690 ATP binding site [chemical binding]; other site 1095774005691 Q-loop/lid; other site 1095774005692 ABC transporter signature motif; other site 1095774005693 Walker B; other site 1095774005694 D-loop; other site 1095774005695 H-loop/switch region; other site 1095774005696 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1095774005697 Walker A/P-loop; other site 1095774005698 ATP binding site [chemical binding]; other site 1095774005699 Q-loop/lid; other site 1095774005700 ABC transporter signature motif; other site 1095774005701 Walker B; other site 1095774005702 D-loop; other site 1095774005703 H-loop/switch region; other site 1095774005704 microcin C ABC transporter permease; Provisional; Region: PRK15021 1095774005705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774005706 dimer interface [polypeptide binding]; other site 1095774005707 conserved gate region; other site 1095774005708 putative PBP binding loops; other site 1095774005709 ABC-ATPase subunit interface; other site 1095774005710 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1095774005711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774005712 dimer interface [polypeptide binding]; other site 1095774005713 conserved gate region; other site 1095774005714 putative PBP binding loops; other site 1095774005715 ABC-ATPase subunit interface; other site 1095774005716 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1095774005717 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1095774005718 phage resistance protein; Provisional; Region: PRK10551 1095774005719 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1095774005720 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1095774005721 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1095774005722 NlpC/P60 family; Region: NLPC_P60; pfam00877 1095774005723 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1095774005724 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1095774005725 active site 1095774005726 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1095774005727 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1095774005728 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 1095774005729 elongation factor P; Provisional; Region: PRK04542 1095774005730 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1095774005731 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1095774005732 RNA binding site [nucleotide binding]; other site 1095774005733 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1095774005734 RNA binding site [nucleotide binding]; other site 1095774005735 Flagellin N-methylase; Region: FliB; pfam03692 1095774005736 benzoate transport; Region: 2A0115; TIGR00895 1095774005737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774005738 putative substrate translocation pore; other site 1095774005739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774005740 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1095774005741 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774005742 DNA binding site [nucleotide binding] 1095774005743 domain linker motif; other site 1095774005744 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1095774005745 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1095774005746 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1095774005747 inhibitor site; inhibition site 1095774005748 active site 1095774005749 dimer interface [polypeptide binding]; other site 1095774005750 catalytic residue [active] 1095774005751 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1095774005752 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1095774005753 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1095774005754 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1095774005755 active site 1095774005756 phosphorylation site [posttranslational modification] 1095774005757 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1095774005758 dimerization domain swap beta strand [polypeptide binding]; other site 1095774005759 regulatory protein interface [polypeptide binding]; other site 1095774005760 active site 1095774005761 regulatory phosphorylation site [posttranslational modification]; other site 1095774005762 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1095774005763 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1095774005764 putative substrate binding site [chemical binding]; other site 1095774005765 putative ATP binding site [chemical binding]; other site 1095774005766 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1095774005767 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1095774005768 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1095774005769 active site 1095774005770 P-loop; other site 1095774005771 phosphorylation site [posttranslational modification] 1095774005772 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1095774005773 endonuclease IV; Provisional; Region: PRK01060 1095774005774 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1095774005775 AP (apurinic/apyrimidinic) site pocket; other site 1095774005776 DNA interaction; other site 1095774005777 Metal-binding active site; metal-binding site 1095774005778 putative transposase; Provisional; Region: PRK09857 1095774005779 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1095774005780 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1095774005781 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 1095774005782 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1095774005783 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774005784 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1095774005785 putative dimerization interface [polypeptide binding]; other site 1095774005786 lysine transporter; Provisional; Region: PRK10836 1095774005787 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1095774005788 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1095774005789 ABC-ATPase subunit interface; other site 1095774005790 dimer interface [polypeptide binding]; other site 1095774005791 putative PBP binding regions; other site 1095774005792 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1095774005793 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1095774005794 Walker A/P-loop; other site 1095774005795 ATP binding site [chemical binding]; other site 1095774005796 Q-loop/lid; other site 1095774005797 ABC transporter signature motif; other site 1095774005798 Walker B; other site 1095774005799 D-loop; other site 1095774005800 H-loop/switch region; other site 1095774005801 S-formylglutathione hydrolase; Region: PLN02442 1095774005802 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1095774005803 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1095774005804 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1095774005805 substrate binding site [chemical binding]; other site 1095774005806 catalytic Zn binding site [ion binding]; other site 1095774005807 NAD binding site [chemical binding]; other site 1095774005808 structural Zn binding site [ion binding]; other site 1095774005809 dimer interface [polypeptide binding]; other site 1095774005810 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774005811 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774005812 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1095774005813 putative dimerization interface [polypeptide binding]; other site 1095774005814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774005815 putative substrate translocation pore; other site 1095774005816 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1095774005817 GTP cyclohydrolase I; Provisional; Region: PLN03044 1095774005818 active site 1095774005819 Predicted membrane protein [Function unknown]; Region: COG2311 1095774005820 hypothetical protein; Provisional; Region: PRK10835 1095774005821 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 1095774005822 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774005823 DNA binding site [nucleotide binding] 1095774005824 domain linker motif; other site 1095774005825 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1095774005826 dimerization interface (closed form) [polypeptide binding]; other site 1095774005827 ligand binding site [chemical binding]; other site 1095774005828 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1095774005829 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1095774005830 ligand binding site [chemical binding]; other site 1095774005831 calcium binding site [ion binding]; other site 1095774005832 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1095774005833 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 1095774005834 Walker A/P-loop; other site 1095774005835 ATP binding site [chemical binding]; other site 1095774005836 Q-loop/lid; other site 1095774005837 ABC transporter signature motif; other site 1095774005838 Walker B; other site 1095774005839 D-loop; other site 1095774005840 H-loop/switch region; other site 1095774005841 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1095774005842 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1095774005843 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1095774005844 TM-ABC transporter signature motif; other site 1095774005845 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1095774005846 putative active site [active] 1095774005847 malate dehydrogenase; Provisional; Region: PRK13529 1095774005848 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1095774005849 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1095774005850 NAD(P) binding site [chemical binding]; other site 1095774005851 cytidine deaminase; Provisional; Region: PRK09027 1095774005852 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1095774005853 active site 1095774005854 catalytic motif [active] 1095774005855 Zn binding site [ion binding]; other site 1095774005856 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1095774005857 active site 1095774005858 catalytic motif [active] 1095774005859 Zn binding site [ion binding]; other site 1095774005860 hypothetical protein; Provisional; Region: PRK10711 1095774005861 hypothetical protein; Provisional; Region: PRK01821 1095774005862 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1095774005863 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1095774005864 active site 1095774005865 HIGH motif; other site 1095774005866 KMSKS motif; other site 1095774005867 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1095774005868 tRNA binding surface [nucleotide binding]; other site 1095774005869 anticodon binding site; other site 1095774005870 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1095774005871 dimer interface [polypeptide binding]; other site 1095774005872 putative tRNA-binding site [nucleotide binding]; other site 1095774005873 antiporter inner membrane protein; Provisional; Region: PRK11670 1095774005874 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1095774005875 Walker A motif; other site 1095774005876 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1095774005877 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774005878 Coenzyme A binding pocket [chemical binding]; other site 1095774005879 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 1095774005880 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1095774005881 dimer interface [polypeptide binding]; other site 1095774005882 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1095774005883 catalytic triad [active] 1095774005884 peroxidatic and resolving cysteines [active] 1095774005885 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1095774005886 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1095774005887 catalytic residue [active] 1095774005888 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1095774005889 catalytic residues [active] 1095774005890 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1095774005891 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1095774005892 Predicted permeases [General function prediction only]; Region: COG0679 1095774005893 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1095774005894 substrate binding site [chemical binding]; other site 1095774005895 multimerization interface [polypeptide binding]; other site 1095774005896 ATP binding site [chemical binding]; other site 1095774005897 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1095774005898 dimer interface [polypeptide binding]; other site 1095774005899 substrate binding site [chemical binding]; other site 1095774005900 ATP binding site [chemical binding]; other site 1095774005901 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774005902 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1095774005903 DNA-binding site [nucleotide binding]; DNA binding site 1095774005904 FCD domain; Region: FCD; pfam07729 1095774005905 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1095774005906 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1095774005907 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1095774005908 lipid kinase; Reviewed; Region: PRK13054 1095774005909 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1095774005910 putative protease; Provisional; Region: PRK15452 1095774005911 Peptidase family U32; Region: Peptidase_U32; pfam01136 1095774005912 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1095774005913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774005914 active site 1095774005915 phosphorylation site [posttranslational modification] 1095774005916 intermolecular recognition site; other site 1095774005917 dimerization interface [polypeptide binding]; other site 1095774005918 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1095774005919 DNA binding site [nucleotide binding] 1095774005920 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1095774005921 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774005922 dimerization interface [polypeptide binding]; other site 1095774005923 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1095774005924 dimer interface [polypeptide binding]; other site 1095774005925 phosphorylation site [posttranslational modification] 1095774005926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774005927 ATP binding site [chemical binding]; other site 1095774005928 Mg2+ binding site [ion binding]; other site 1095774005929 G-X-G motif; other site 1095774005930 putative transporter; Provisional; Region: PRK10504 1095774005931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774005932 putative substrate translocation pore; other site 1095774005933 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1095774005934 Protein export membrane protein; Region: SecD_SecF; cl14618 1095774005935 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1095774005936 Protein export membrane protein; Region: SecD_SecF; cl14618 1095774005937 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1095774005938 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1095774005939 HlyD family secretion protein; Region: HlyD_3; pfam13437 1095774005940 Ubiquitin elongating factor core; Region: Ufd2P_core; pfam10408 1095774005941 putative chaperone; Provisional; Region: PRK11678 1095774005942 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1095774005943 nucleotide binding site [chemical binding]; other site 1095774005944 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1095774005945 SBD interface [polypeptide binding]; other site 1095774005946 MASE1; Region: MASE1; cl17823 1095774005947 putative diguanylate cyclase; Provisional; Region: PRK09776 1095774005948 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1095774005949 putative active site [active] 1095774005950 heme pocket [chemical binding]; other site 1095774005951 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1095774005952 putative active site [active] 1095774005953 heme pocket [chemical binding]; other site 1095774005954 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1095774005955 putative active site [active] 1095774005956 heme pocket [chemical binding]; other site 1095774005957 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1095774005958 metal binding site [ion binding]; metal-binding site 1095774005959 active site 1095774005960 I-site; other site 1095774005961 EAL domain; Region: EAL; pfam00563 1095774005962 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1095774005963 active site 1095774005964 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1095774005965 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1095774005966 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1095774005967 ATP-binding site [chemical binding]; other site 1095774005968 Sugar specificity; other site 1095774005969 Pyrimidine base specificity; other site 1095774005970 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1095774005971 trimer interface [polypeptide binding]; other site 1095774005972 active site 1095774005973 putative assembly protein; Provisional; Region: PRK10833 1095774005974 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1095774005975 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1095774005976 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1095774005977 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1095774005978 Transporter associated domain; Region: CorC_HlyC; smart01091 1095774005979 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 1095774005980 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1095774005981 polysaccharide export protein Wza; Provisional; Region: PRK15078 1095774005982 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1095774005983 SLBB domain; Region: SLBB; pfam10531 1095774005984 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1095774005985 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1095774005986 active site 1095774005987 tyrosine kinase; Provisional; Region: PRK11519 1095774005988 Chain length determinant protein; Region: Wzz; pfam02706 1095774005989 Chain length determinant protein; Region: Wzz; cl15801 1095774005990 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1095774005991 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1095774005992 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1095774005993 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1095774005994 active site 1095774005995 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1095774005996 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1095774005997 active site 1095774005998 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1095774005999 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1095774006000 putative ADP-binding pocket [chemical binding]; other site 1095774006001 Head binding; Region: Head_binding; pfam09008 1095774006002 colanic acid biosynthesis protein; Provisional; Region: PRK10017 1095774006003 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1095774006004 colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427 1095774006005 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1095774006006 putative ADP-binding pocket [chemical binding]; other site 1095774006007 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1095774006008 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1095774006009 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1095774006010 active site 1095774006011 tetramer interface; other site 1095774006012 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1095774006013 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1095774006014 NAD binding site [chemical binding]; other site 1095774006015 homodimer interface [polypeptide binding]; other site 1095774006016 active site 1095774006017 substrate binding site [chemical binding]; other site 1095774006018 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 1095774006019 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1095774006020 Mg++ binding site [ion binding]; other site 1095774006021 putative catalytic motif [active] 1095774006022 substrate binding site [chemical binding]; other site 1095774006023 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 1095774006024 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1095774006025 NAD binding site [chemical binding]; other site 1095774006026 substrate binding site [chemical binding]; other site 1095774006027 homodimer interface [polypeptide binding]; other site 1095774006028 active site 1095774006029 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 1095774006030 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1095774006031 NADP binding site [chemical binding]; other site 1095774006032 active site 1095774006033 putative substrate binding site [chemical binding]; other site 1095774006034 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1095774006035 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1095774006036 substrate binding site; other site 1095774006037 tetramer interface; other site 1095774006038 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1095774006039 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1095774006040 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1095774006041 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1095774006042 active site 1095774006043 dimer interface [polypeptide binding]; other site 1095774006044 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1095774006045 Ligand Binding Site [chemical binding]; other site 1095774006046 Molecular Tunnel; other site 1095774006047 Protein of unknown function (DUF616); Region: DUF616; pfam04765 1095774006048 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 1095774006049 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 1095774006050 Ligand binding site; other site 1095774006051 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1095774006052 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1095774006053 active site 1095774006054 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1095774006055 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1095774006056 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1095774006057 chain length determinant protein WzzB; Provisional; Region: PRK15471 1095774006058 Chain length determinant protein; Region: Wzz; cl15801 1095774006059 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 1095774006060 active site 1095774006061 Zn binding site [ion binding]; other site 1095774006062 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1095774006063 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1095774006064 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774006065 substrate binding pocket [chemical binding]; other site 1095774006066 membrane-bound complex binding site; other site 1095774006067 hinge residues; other site 1095774006068 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 1095774006069 putative deacylase active site [active] 1095774006070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1095774006071 non-specific DNA binding site [nucleotide binding]; other site 1095774006072 salt bridge; other site 1095774006073 sequence-specific DNA binding site [nucleotide binding]; other site 1095774006074 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1095774006075 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1095774006076 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1095774006077 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1095774006078 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1095774006079 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1095774006080 metal binding site [ion binding]; metal-binding site 1095774006081 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1095774006082 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1095774006083 substrate binding site [chemical binding]; other site 1095774006084 glutamase interaction surface [polypeptide binding]; other site 1095774006085 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1095774006086 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1095774006087 catalytic residues [active] 1095774006088 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1095774006089 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1095774006090 putative active site [active] 1095774006091 oxyanion strand; other site 1095774006092 catalytic triad [active] 1095774006093 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1095774006094 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774006095 active site 1095774006096 motif I; other site 1095774006097 motif II; other site 1095774006098 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1095774006099 putative active site pocket [active] 1095774006100 4-fold oligomerization interface [polypeptide binding]; other site 1095774006101 metal binding residues [ion binding]; metal-binding site 1095774006102 3-fold/trimer interface [polypeptide binding]; other site 1095774006103 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1095774006104 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1095774006105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774006106 homodimer interface [polypeptide binding]; other site 1095774006107 catalytic residue [active] 1095774006108 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1095774006109 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1095774006110 NAD binding site [chemical binding]; other site 1095774006111 dimerization interface [polypeptide binding]; other site 1095774006112 product binding site; other site 1095774006113 substrate binding site [chemical binding]; other site 1095774006114 zinc binding site [ion binding]; other site 1095774006115 catalytic residues [active] 1095774006116 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1095774006117 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1095774006118 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1095774006119 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1095774006120 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1095774006121 putative NAD(P) binding site [chemical binding]; other site 1095774006122 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1095774006123 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1095774006124 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1095774006125 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1095774006126 non-specific DNA binding site [nucleotide binding]; other site 1095774006127 salt bridge; other site 1095774006128 sequence-specific DNA binding site [nucleotide binding]; other site 1095774006129 Cupin domain; Region: Cupin_2; pfam07883 1095774006130 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 1095774006131 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1095774006132 catalytic triad [active] 1095774006133 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1095774006134 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1095774006135 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1095774006136 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1095774006137 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1095774006138 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1095774006139 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1095774006140 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1095774006141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1095774006142 putative aldolase; Validated; Region: PRK08130 1095774006143 intersubunit interface [polypeptide binding]; other site 1095774006144 active site 1095774006145 Zn2+ binding site [ion binding]; other site 1095774006146 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1095774006147 putative transporter; Provisional; Region: PRK09821 1095774006148 GntP family permease; Region: GntP_permease; pfam02447 1095774006149 exonuclease I; Provisional; Region: sbcB; PRK11779 1095774006150 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1095774006151 active site 1095774006152 catalytic site [active] 1095774006153 substrate binding site [chemical binding]; other site 1095774006154 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1095774006155 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1095774006156 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1095774006157 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1095774006158 Predicted membrane protein [Function unknown]; Region: COG1289 1095774006159 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1095774006160 hypothetical protein; Provisional; Region: PRK05423 1095774006161 lac repressor; Reviewed; Region: lacI; PRK09526 1095774006162 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774006163 DNA binding site [nucleotide binding] 1095774006164 domain linker motif; other site 1095774006165 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1095774006166 ligand binding site [chemical binding]; other site 1095774006167 dimerization interface (open form) [polypeptide binding]; other site 1095774006168 dimerization interface (closed form) [polypeptide binding]; other site 1095774006169 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1095774006170 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1095774006171 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1095774006172 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1095774006173 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1095774006174 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1095774006175 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1095774006176 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 1095774006177 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 1095774006178 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1095774006179 NAD binding site [chemical binding]; other site 1095774006180 catalytic residues [active] 1095774006181 substrate binding site [chemical binding]; other site 1095774006182 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1095774006183 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1095774006184 transcriptional activator RhaR; Provisional; Region: PRK13501 1095774006185 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1095774006186 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774006187 transcriptional activator RhaS; Provisional; Region: PRK13503 1095774006188 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1095774006189 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774006190 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1095774006191 N- and C-terminal domain interface [polypeptide binding]; other site 1095774006192 active site 1095774006193 putative catalytic site [active] 1095774006194 metal binding site [ion binding]; metal-binding site 1095774006195 ATP binding site [chemical binding]; other site 1095774006196 rhamnulokinase; Provisional; Region: rhaB; PRK10640 1095774006197 carbohydrate binding site [chemical binding]; other site 1095774006198 L-rhamnose isomerase; Provisional; Region: PRK01076 1095774006199 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1095774006200 rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634 1095774006201 intersubunit interface [polypeptide binding]; other site 1095774006202 active site 1095774006203 Zn2+ binding site [ion binding]; other site 1095774006204 Domain of unknown function (DUF718); Region: DUF718; cl01281 1095774006205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1095774006206 non-specific DNA binding site [nucleotide binding]; other site 1095774006207 salt bridge; other site 1095774006208 sequence-specific DNA binding site [nucleotide binding]; other site 1095774006209 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1095774006210 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1095774006211 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1095774006212 Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537 1095774006213 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1095774006214 substrate binding site; other site 1095774006215 Manganese binding site; other site 1095774006216 dimer interface; other site 1095774006217 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1095774006218 FAD binding domain; Region: FAD_binding_4; pfam01565 1095774006219 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1095774006220 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1095774006221 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1095774006222 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1095774006223 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1095774006224 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1095774006225 putative DNA binding site [nucleotide binding]; other site 1095774006226 putative Zn2+ binding site [ion binding]; other site 1095774006227 AsnC family; Region: AsnC_trans_reg; pfam01037 1095774006228 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1095774006229 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1095774006230 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1095774006231 active site 1095774006232 substrate binding site [chemical binding]; other site 1095774006233 Mg2+ binding site [ion binding]; other site 1095774006234 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1095774006235 catalytic loop [active] 1095774006236 iron binding site [ion binding]; other site 1095774006237 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1095774006238 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774006239 dimer interface [polypeptide binding]; other site 1095774006240 putative CheW interface [polypeptide binding]; other site 1095774006241 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1095774006242 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1095774006243 putative ligand binding site [chemical binding]; other site 1095774006244 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1095774006245 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1095774006246 Walker A/P-loop; other site 1095774006247 ATP binding site [chemical binding]; other site 1095774006248 Q-loop/lid; other site 1095774006249 ABC transporter signature motif; other site 1095774006250 Walker B; other site 1095774006251 D-loop; other site 1095774006252 H-loop/switch region; other site 1095774006253 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1095774006254 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1095774006255 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1095774006256 TM-ABC transporter signature motif; other site 1095774006257 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1095774006258 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774006259 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1095774006260 putative dimerization interface [polypeptide binding]; other site 1095774006261 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 1095774006262 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774006263 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1095774006264 substrate binding site [chemical binding]; other site 1095774006265 dimerization interface [polypeptide binding]; other site 1095774006266 succinic semialdehyde dehydrogenase; Region: PLN02278 1095774006267 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1095774006268 tetramerization interface [polypeptide binding]; other site 1095774006269 NAD(P) binding site [chemical binding]; other site 1095774006270 catalytic residues [active] 1095774006271 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1095774006272 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1095774006273 NAD(P) binding site [chemical binding]; other site 1095774006274 catalytic residues [active] 1095774006275 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1095774006276 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774006277 motif II; other site 1095774006278 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1095774006279 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1095774006280 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1095774006281 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1095774006282 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1095774006283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774006284 dimer interface [polypeptide binding]; other site 1095774006285 conserved gate region; other site 1095774006286 putative PBP binding loops; other site 1095774006287 ABC-ATPase subunit interface; other site 1095774006288 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1095774006289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774006290 dimer interface [polypeptide binding]; other site 1095774006291 conserved gate region; other site 1095774006292 ABC-ATPase subunit interface; other site 1095774006293 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1095774006294 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1095774006295 Walker A/P-loop; other site 1095774006296 ATP binding site [chemical binding]; other site 1095774006297 Q-loop/lid; other site 1095774006298 ABC transporter signature motif; other site 1095774006299 Walker B; other site 1095774006300 D-loop; other site 1095774006301 H-loop/switch region; other site 1095774006302 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1095774006303 Walker A/P-loop; other site 1095774006304 ATP binding site [chemical binding]; other site 1095774006305 Q-loop/lid; other site 1095774006306 ABC transporter signature motif; other site 1095774006307 Walker B; other site 1095774006308 D-loop; other site 1095774006309 H-loop/switch region; other site 1095774006310 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1095774006311 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1095774006312 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1095774006313 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774006314 Coenzyme A binding pocket [chemical binding]; other site 1095774006315 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1095774006316 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1095774006317 putative ligand binding site [chemical binding]; other site 1095774006318 NAD binding site [chemical binding]; other site 1095774006319 dimerization interface [polypeptide binding]; other site 1095774006320 catalytic site [active] 1095774006321 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1095774006322 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1095774006323 metal binding site [ion binding]; metal-binding site 1095774006324 putative dimer interface [polypeptide binding]; other site 1095774006325 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1095774006326 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1095774006327 inhibitor-cofactor binding pocket; inhibition site 1095774006328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774006329 catalytic residue [active] 1095774006330 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1095774006331 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1095774006332 putative DNA binding site [nucleotide binding]; other site 1095774006333 putative Zn2+ binding site [ion binding]; other site 1095774006334 AsnC family; Region: AsnC_trans_reg; pfam01037 1095774006335 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1095774006336 active site 1095774006337 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1095774006338 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1095774006339 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1095774006340 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1095774006341 Na binding site [ion binding]; other site 1095774006342 Isochorismatase family; Region: Isochorismatase; pfam00857 1095774006343 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1095774006344 catalytic triad [active] 1095774006345 conserved cis-peptide bond; other site 1095774006346 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 1095774006347 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774006348 DNA-binding site [nucleotide binding]; DNA binding site 1095774006349 UTRA domain; Region: UTRA; pfam07702 1095774006350 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 1095774006351 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 1095774006352 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 1095774006353 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 1095774006354 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 1095774006355 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1095774006356 Walker A/P-loop; other site 1095774006357 ATP binding site [chemical binding]; other site 1095774006358 Q-loop/lid; other site 1095774006359 ABC transporter signature motif; other site 1095774006360 Walker B; other site 1095774006361 D-loop; other site 1095774006362 H-loop/switch region; other site 1095774006363 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1095774006364 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 1095774006365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774006366 Walker A/P-loop; other site 1095774006367 ATP binding site [chemical binding]; other site 1095774006368 Q-loop/lid; other site 1095774006369 ABC transporter signature motif; other site 1095774006370 Walker B; other site 1095774006371 D-loop; other site 1095774006372 H-loop/switch region; other site 1095774006373 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 1095774006374 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1095774006375 active site 1095774006376 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1095774006377 putative hydrolase; Provisional; Region: PRK02113 1095774006378 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1095774006379 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1095774006380 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1095774006381 Walker A/P-loop; other site 1095774006382 ATP binding site [chemical binding]; other site 1095774006383 Q-loop/lid; other site 1095774006384 ABC transporter signature motif; other site 1095774006385 Walker B; other site 1095774006386 D-loop; other site 1095774006387 H-loop/switch region; other site 1095774006388 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 1095774006389 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1095774006390 substrate binding pocket [chemical binding]; other site 1095774006391 membrane-bound complex binding site; other site 1095774006392 hinge residues; other site 1095774006393 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1095774006394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774006395 dimer interface [polypeptide binding]; other site 1095774006396 conserved gate region; other site 1095774006397 putative PBP binding loops; other site 1095774006398 ABC-ATPase subunit interface; other site 1095774006399 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1095774006400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774006401 dimer interface [polypeptide binding]; other site 1095774006402 conserved gate region; other site 1095774006403 ABC-ATPase subunit interface; other site 1095774006404 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1095774006405 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774006406 dimerization interface [polypeptide binding]; other site 1095774006407 PAS fold; Region: PAS_7; pfam12860 1095774006408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774006409 ATP binding site [chemical binding]; other site 1095774006410 Mg2+ binding site [ion binding]; other site 1095774006411 G-X-G motif; other site 1095774006412 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1095774006413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774006414 active site 1095774006415 phosphorylation site [posttranslational modification] 1095774006416 intermolecular recognition site; other site 1095774006417 dimerization interface [polypeptide binding]; other site 1095774006418 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1095774006419 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1095774006420 Walker A/P-loop; other site 1095774006421 ATP binding site [chemical binding]; other site 1095774006422 Q-loop/lid; other site 1095774006423 ABC transporter signature motif; other site 1095774006424 Walker B; other site 1095774006425 D-loop; other site 1095774006426 H-loop/switch region; other site 1095774006427 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1095774006428 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1095774006429 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1095774006430 TM-ABC transporter signature motif; other site 1095774006431 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1095774006432 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 1095774006433 putative ligand binding site [chemical binding]; other site 1095774006434 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1095774006435 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1095774006436 intersubunit interface [polypeptide binding]; other site 1095774006437 active site 1095774006438 zinc binding site [ion binding]; other site 1095774006439 Na+ binding site [ion binding]; other site 1095774006440 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1095774006441 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1095774006442 substrate binding site [chemical binding]; other site 1095774006443 ATP binding site [chemical binding]; other site 1095774006444 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1095774006445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774006446 active site 1095774006447 phosphorylation site [posttranslational modification] 1095774006448 intermolecular recognition site; other site 1095774006449 dimerization interface [polypeptide binding]; other site 1095774006450 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1095774006451 DNA binding site [nucleotide binding] 1095774006452 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1095774006453 AMP nucleosidase; Provisional; Region: PRK08292 1095774006454 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1095774006455 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1095774006456 MATE family multidrug exporter; Provisional; Region: PRK10189 1095774006457 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1095774006458 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1095774006459 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1095774006460 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1095774006461 hypothetical protein; Provisional; Region: PRK07033 1095774006462 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1095774006463 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1095774006464 ligand binding site [chemical binding]; other site 1095774006465 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1095774006466 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1095774006467 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1095774006468 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 1095774006469 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1095774006470 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1095774006471 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 1095774006472 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1095774006473 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1095774006474 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1095774006475 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1095774006476 Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772 1095774006477 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1095774006478 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1095774006479 phosphopeptide binding site; other site 1095774006480 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1095774006481 active site 1095774006482 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 1095774006483 ImpE protein; Region: ImpE; pfam07024 1095774006484 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1095774006485 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1095774006486 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1095774006487 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1095774006488 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1095774006489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774006490 Walker A motif; other site 1095774006491 ATP binding site [chemical binding]; other site 1095774006492 Walker B motif; other site 1095774006493 arginine finger; other site 1095774006494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774006495 Walker A motif; other site 1095774006496 ATP binding site [chemical binding]; other site 1095774006497 Walker B motif; other site 1095774006498 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1095774006499 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1095774006500 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1095774006501 active site 1095774006502 ATP binding site [chemical binding]; other site 1095774006503 substrate binding site [chemical binding]; other site 1095774006504 activation loop (A-loop); other site 1095774006505 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1095774006506 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1095774006507 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1095774006508 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 1095774006509 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1095774006510 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1095774006511 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1095774006512 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1095774006513 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1095774006514 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1095774006515 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1095774006516 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1095774006517 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1095774006518 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1095774006519 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 1095774006520 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1095774006521 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1095774006522 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1095774006523 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1095774006524 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1095774006525 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1095774006526 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 1095774006527 PAAR motif; Region: PAAR_motif; pfam05488 1095774006528 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1095774006529 RHS Repeat; Region: RHS_repeat; pfam05593 1095774006530 RHS Repeat; Region: RHS_repeat; pfam05593 1095774006531 RHS Repeat; Region: RHS_repeat; pfam05593 1095774006532 RHS protein; Region: RHS; pfam03527 1095774006533 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1095774006534 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1095774006535 active site 1095774006536 phosphorylation site [posttranslational modification] 1095774006537 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1095774006538 active site 1095774006539 P-loop; other site 1095774006540 phosphorylation site [posttranslational modification] 1095774006541 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1095774006542 alpha-mannosidase; Provisional; Region: PRK09819 1095774006543 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 1095774006544 active site 1095774006545 metal binding site [ion binding]; metal-binding site 1095774006546 catalytic site [active] 1095774006547 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 1095774006548 HTH domain; Region: HTH_11; pfam08279 1095774006549 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1095774006550 PRD domain; Region: PRD; pfam00874 1095774006551 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1095774006552 active site 1095774006553 P-loop; other site 1095774006554 phosphorylation site [posttranslational modification] 1095774006555 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1095774006556 active site 1095774006557 phosphorylation site [posttranslational modification] 1095774006558 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1095774006559 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1095774006560 putative dimer interface [polypeptide binding]; other site 1095774006561 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1095774006562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774006563 Walker A/P-loop; other site 1095774006564 ATP binding site [chemical binding]; other site 1095774006565 Q-loop/lid; other site 1095774006566 ABC transporter signature motif; other site 1095774006567 Walker B; other site 1095774006568 D-loop; other site 1095774006569 H-loop/switch region; other site 1095774006570 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1095774006571 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1095774006572 putative ligand binding residues [chemical binding]; other site 1095774006573 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1095774006574 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1095774006575 ABC-ATPase subunit interface; other site 1095774006576 dimer interface [polypeptide binding]; other site 1095774006577 putative PBP binding regions; other site 1095774006578 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1095774006579 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1095774006580 enterobactin exporter EntS; Provisional; Region: PRK10489 1095774006581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774006582 putative substrate translocation pore; other site 1095774006583 ferrochelatase; Reviewed; Region: hemH; PRK00035 1095774006584 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1095774006585 C-terminal domain interface [polypeptide binding]; other site 1095774006586 active site 1095774006587 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1095774006588 active site 1095774006589 N-terminal domain interface [polypeptide binding]; other site 1095774006590 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1095774006591 PemK-like protein; Region: PemK; cl00995 1095774006592 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 1095774006593 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1095774006594 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1095774006595 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1095774006596 Zn2+ binding site [ion binding]; other site 1095774006597 Mg2+ binding site [ion binding]; other site 1095774006598 bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982 1095774006599 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1095774006600 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1095774006601 dimer interface [polypeptide binding]; other site 1095774006602 ligand binding site [chemical binding]; other site 1095774006603 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774006604 dimer interface [polypeptide binding]; other site 1095774006605 putative CheW interface [polypeptide binding]; other site 1095774006606 DNA cytosine methylase; Provisional; Region: PRK10458 1095774006607 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1095774006608 cofactor binding site; other site 1095774006609 DNA binding site [nucleotide binding] 1095774006610 substrate interaction site [chemical binding]; other site 1095774006611 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1095774006612 additional DNA contacts [nucleotide binding]; other site 1095774006613 mismatch recognition site; other site 1095774006614 active site 1095774006615 zinc binding site [ion binding]; other site 1095774006616 DNA intercalation site [nucleotide binding]; other site 1095774006617 hypothetical protein; Provisional; Region: PRK10062 1095774006618 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 1095774006619 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1095774006620 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 1095774006621 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774006622 active site 1095774006623 motif I; other site 1095774006624 motif II; other site 1095774006625 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1095774006626 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 1095774006627 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1095774006628 hypothetical protein; Provisional; Region: PRK10708 1095774006629 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1095774006630 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1095774006631 dimer interface [polypeptide binding]; other site 1095774006632 ligand binding site [chemical binding]; other site 1095774006633 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774006634 dimerization interface [polypeptide binding]; other site 1095774006635 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774006636 dimer interface [polypeptide binding]; other site 1095774006637 putative CheW interface [polypeptide binding]; other site 1095774006638 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1095774006639 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1095774006640 DNA binding residues [nucleotide binding] 1095774006641 dimerization interface [polypeptide binding]; other site 1095774006642 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1095774006643 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1095774006644 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1095774006645 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 1095774006646 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 1095774006647 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1095774006648 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1095774006649 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1095774006650 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1095774006651 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 1095774006652 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1095774006653 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1095774006654 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 1095774006655 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1095774006656 Walker A motif/ATP binding site; other site 1095774006657 Walker B motif; other site 1095774006658 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1095774006659 Flagellar assembly protein FliH; Region: FliH; pfam02108 1095774006660 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1095774006661 FliG C-terminal domain; Region: FliG_C; pfam01706 1095774006662 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1095774006663 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1095774006664 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1095774006665 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1095774006666 DinI-like family; Region: DinI; cl11630 1095774006667 anti-RssB factor; Provisional; Region: PRK10244 1095774006668 lipoprotein; Provisional; Region: PRK10397 1095774006669 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1095774006670 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1095774006671 active site 1095774006672 Na/Ca binding site [ion binding]; other site 1095774006673 catalytic site [active] 1095774006674 Flagellar protein FliT; Region: FliT; cl05125 1095774006675 flagellar protein FliS; Validated; Region: fliS; PRK05685 1095774006676 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1095774006677 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1095774006678 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1095774006679 flagellin; Provisional; Region: PRK12802 1095774006680 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1095774006681 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1095774006682 flagellin; Reviewed; Region: PRK08869 1095774006683 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1095774006684 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1095774006685 flagellin; Provisional; Region: PRK12802 1095774006686 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1095774006687 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1095774006688 flagellin; Provisional; Region: PRK12802 1095774006689 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1095774006690 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1095774006691 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1095774006692 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1095774006693 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1095774006694 Probable Catalytic site; other site 1095774006695 metal-binding site 1095774006696 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1095774006697 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1095774006698 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1095774006699 active site 1095774006700 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1095774006701 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1095774006702 inhibitor-cofactor binding pocket; inhibition site 1095774006703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774006704 catalytic residue [active] 1095774006705 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1095774006706 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1095774006707 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1095774006708 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1095774006709 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1095774006710 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1095774006711 NADP binding site [chemical binding]; other site 1095774006712 active site 1095774006713 putative substrate binding site [chemical binding]; other site 1095774006714 HNH endonuclease; Region: HNH_2; pfam13391 1095774006715 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1095774006716 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1095774006717 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1095774006718 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1095774006719 DNA binding residues [nucleotide binding] 1095774006720 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 1095774006721 D-cysteine desulfhydrase; Validated; Region: PRK03910 1095774006722 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1095774006723 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1095774006724 catalytic residue [active] 1095774006725 cystine transporter subunit; Provisional; Region: PRK11260 1095774006726 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774006727 substrate binding pocket [chemical binding]; other site 1095774006728 membrane-bound complex binding site; other site 1095774006729 hinge residues; other site 1095774006730 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1095774006731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774006732 dimer interface [polypeptide binding]; other site 1095774006733 conserved gate region; other site 1095774006734 putative PBP binding loops; other site 1095774006735 ABC-ATPase subunit interface; other site 1095774006736 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1095774006737 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1095774006738 Walker A/P-loop; other site 1095774006739 ATP binding site [chemical binding]; other site 1095774006740 Q-loop/lid; other site 1095774006741 ABC transporter signature motif; other site 1095774006742 Walker B; other site 1095774006743 D-loop; other site 1095774006744 H-loop/switch region; other site 1095774006745 Predicted membrane protein [Function unknown]; Region: COG4763 1095774006746 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1095774006747 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1095774006748 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1095774006749 dimer interface [polypeptide binding]; other site 1095774006750 ADP-ribose binding site [chemical binding]; other site 1095774006751 active site 1095774006752 nudix motif; other site 1095774006753 metal binding site [ion binding]; metal-binding site 1095774006754 Predicted membrane protein [Function unknown]; Region: COG4763 1095774006755 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1095774006756 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1095774006757 Predicted transcriptional regulator [Transcription]; Region: COG3905 1095774006758 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1095774006759 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1095774006760 Glutamate binding site [chemical binding]; other site 1095774006761 NAD binding site [chemical binding]; other site 1095774006762 catalytic residues [active] 1095774006763 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1095774006764 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1095774006765 Na binding site [ion binding]; other site 1095774006766 Iron permease FTR1 family; Region: FTR1; cl00475 1095774006767 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 1095774006768 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1095774006769 Imelysin; Region: Peptidase_M75; pfam09375 1095774006770 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1095774006771 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1095774006772 hypothetical protein; Provisional; Region: PRK10536 1095774006773 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1095774006774 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1095774006775 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1095774006776 active site 1095774006777 benzoate transport; Region: 2A0115; TIGR00895 1095774006778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774006779 putative substrate translocation pore; other site 1095774006780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774006781 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1095774006782 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1095774006783 non-prolyl cis peptide bond; other site 1095774006784 active site 1095774006785 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1095774006786 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1095774006787 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1095774006788 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1095774006789 active site 1095774006790 dimer interface [polypeptide binding]; other site 1095774006791 non-prolyl cis peptide bond; other site 1095774006792 insertion regions; other site 1095774006793 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1095774006794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774006795 Walker A motif; other site 1095774006796 ATP binding site [chemical binding]; other site 1095774006797 Walker B motif; other site 1095774006798 arginine finger; other site 1095774006799 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1095774006800 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1095774006801 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774006802 substrate binding pocket [chemical binding]; other site 1095774006803 membrane-bound complex binding site; other site 1095774006804 hinge residues; other site 1095774006805 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1095774006806 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774006807 substrate binding pocket [chemical binding]; other site 1095774006808 membrane-bound complex binding site; other site 1095774006809 hinge residues; other site 1095774006810 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 1095774006811 Predicted transcriptional regulator [Transcription]; Region: COG2944 1095774006812 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1095774006813 non-specific DNA binding site [nucleotide binding]; other site 1095774006814 salt bridge; other site 1095774006815 sequence-specific DNA binding site [nucleotide binding]; other site 1095774006816 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1095774006817 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1095774006818 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1095774006819 active site 1095774006820 DNA binding site [nucleotide binding] 1095774006821 Int/Topo IB signature motif; other site 1095774006822 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1095774006823 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1095774006824 cofactor binding site; other site 1095774006825 DNA binding site [nucleotide binding] 1095774006826 substrate interaction site [chemical binding]; other site 1095774006827 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1095774006828 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 1095774006829 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440 1095774006830 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1095774006831 AAA domain; Region: AAA_22; pfam13401 1095774006832 exodeoxyribonuclease X; Provisional; Region: PRK07983 1095774006833 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1095774006834 active site 1095774006835 catalytic site [active] 1095774006836 substrate binding site [chemical binding]; other site 1095774006837 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1095774006838 non-specific DNA binding site [nucleotide binding]; other site 1095774006839 salt bridge; other site 1095774006840 sequence-specific DNA binding site [nucleotide binding]; other site 1095774006841 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1095774006842 Catalytic site [active] 1095774006843 Bacteriophage CII protein; Region: Phage_CII; pfam05269 1095774006844 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 1095774006845 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 1095774006846 replicative DNA helicase; Region: DnaB; TIGR00665 1095774006847 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1095774006848 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1095774006849 Walker A motif; other site 1095774006850 ATP binding site [chemical binding]; other site 1095774006851 Walker B motif; other site 1095774006852 DNA binding loops [nucleotide binding] 1095774006853 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1095774006854 Antitermination protein; Region: Antiterm; pfam03589 1095774006855 Antitermination protein; Region: Antiterm; pfam03589 1095774006856 Lysis protein S; Region: Lysis_S; pfam04971 1095774006857 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1095774006858 catalytic residues [active] 1095774006859 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1095774006860 Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045 1095774006861 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1095774006862 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 1095774006863 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 1095774006864 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1095774006865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566 1095774006866 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 1095774006867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 1095774006868 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 1095774006869 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 1095774006870 Superfamily II helicase, archaea-specific [General function prediction only]; Region: COG1202 1095774006871 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 1095774006872 Protein of unknown function (DUF3277); Region: DUF3277; pfam11681 1095774006873 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1095774006874 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1095774006875 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1095774006876 catalytic residue [active] 1095774006877 Baseplate J-like protein; Region: Baseplate_J; cl01294 1095774006878 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 1095774006879 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1095774006880 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1095774006881 sensor protein BasS/PmrB; Provisional; Region: PRK10755 1095774006882 HAMP domain; Region: HAMP; pfam00672 1095774006883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1095774006884 dimer interface [polypeptide binding]; other site 1095774006885 phosphorylation site [posttranslational modification] 1095774006886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774006887 ATP binding site [chemical binding]; other site 1095774006888 Mg2+ binding site [ion binding]; other site 1095774006889 G-X-G motif; other site 1095774006890 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1095774006891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774006892 active site 1095774006893 phosphorylation site [posttranslational modification] 1095774006894 intermolecular recognition site; other site 1095774006895 dimerization interface [polypeptide binding]; other site 1095774006896 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1095774006897 DNA binding site [nucleotide binding] 1095774006898 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1095774006899 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 1095774006900 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1095774006901 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1095774006902 active site 1095774006903 homotetramer interface [polypeptide binding]; other site 1095774006904 transcriptional activator FlhD; Provisional; Region: PRK02909 1095774006905 transcriptional activator FlhC; Provisional; Region: PRK12722 1095774006906 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1095774006907 flagellar motor protein MotA; Validated; Region: PRK09110 1095774006908 flagellar motor protein MotB; Validated; Region: motB; PRK09041 1095774006909 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1095774006910 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1095774006911 ligand binding site [chemical binding]; other site 1095774006912 chemotaxis protein CheA; Provisional; Region: PRK10547 1095774006913 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1095774006914 putative binding surface; other site 1095774006915 active site 1095774006916 CheY binding; Region: CheY-binding; pfam09078 1095774006917 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1095774006918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774006919 ATP binding site [chemical binding]; other site 1095774006920 Mg2+ binding site [ion binding]; other site 1095774006921 G-X-G motif; other site 1095774006922 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1095774006923 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1095774006924 putative CheA interaction surface; other site 1095774006925 methyl-accepting protein IV; Provisional; Region: PRK09793 1095774006926 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1095774006927 dimer interface [polypeptide binding]; other site 1095774006928 ligand binding site [chemical binding]; other site 1095774006929 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774006930 dimerization interface [polypeptide binding]; other site 1095774006931 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774006932 dimer interface [polypeptide binding]; other site 1095774006933 putative CheW interface [polypeptide binding]; other site 1095774006934 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1095774006935 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1095774006936 dimer interface [polypeptide binding]; other site 1095774006937 ligand binding site [chemical binding]; other site 1095774006938 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774006939 dimerization interface [polypeptide binding]; other site 1095774006940 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774006941 dimer interface [polypeptide binding]; other site 1095774006942 putative CheW interface [polypeptide binding]; other site 1095774006943 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 1095774006944 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1095774006945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774006946 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1095774006947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774006948 active site 1095774006949 phosphorylation site [posttranslational modification] 1095774006950 intermolecular recognition site; other site 1095774006951 dimerization interface [polypeptide binding]; other site 1095774006952 CheB methylesterase; Region: CheB_methylest; pfam01339 1095774006953 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1095774006954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774006955 active site 1095774006956 phosphorylation site [posttranslational modification] 1095774006957 intermolecular recognition site; other site 1095774006958 dimerization interface [polypeptide binding]; other site 1095774006959 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1095774006960 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468 1095774006961 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1095774006962 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1095774006963 FHIPEP family; Region: FHIPEP; pfam00771 1095774006964 Flagellar protein FlhE; Region: FlhE; pfam06366 1095774006965 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1095774006966 amphipathic channel; other site 1095774006967 Asn-Pro-Ala signature motifs; other site 1095774006968 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1095774006969 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1095774006970 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1095774006971 active site 1095774006972 HIGH motif; other site 1095774006973 KMSK motif region; other site 1095774006974 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1095774006975 tRNA binding surface [nucleotide binding]; other site 1095774006976 anticodon binding site; other site 1095774006977 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1095774006978 putative metal binding site [ion binding]; other site 1095774006979 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 1095774006980 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1095774006981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774006982 homodimer interface [polypeptide binding]; other site 1095774006983 catalytic residue [active] 1095774006984 copper homeostasis protein CutC; Provisional; Region: PRK11572 1095774006985 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1095774006986 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1095774006987 dimer interface [polypeptide binding]; other site 1095774006988 active site 1095774006989 metal binding site [ion binding]; metal-binding site 1095774006990 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1095774006991 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1095774006992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774006993 S-adenosylmethionine binding site [chemical binding]; other site 1095774006994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774006995 S-adenosylmethionine binding site [chemical binding]; other site 1095774006996 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1095774006997 hypothetical protein; Provisional; Region: PRK10302 1095774006998 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1095774006999 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1095774007000 dimer interface [polypeptide binding]; other site 1095774007001 anticodon binding site; other site 1095774007002 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1095774007003 homodimer interface [polypeptide binding]; other site 1095774007004 motif 1; other site 1095774007005 active site 1095774007006 motif 2; other site 1095774007007 GAD domain; Region: GAD; pfam02938 1095774007008 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1095774007009 active site 1095774007010 motif 3; other site 1095774007011 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1095774007012 nudix motif; other site 1095774007013 hypothetical protein; Validated; Region: PRK00110 1095774007014 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1095774007015 active site 1095774007016 putative DNA-binding cleft [nucleotide binding]; other site 1095774007017 dimer interface [polypeptide binding]; other site 1095774007018 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1095774007019 RuvA N terminal domain; Region: RuvA_N; pfam01330 1095774007020 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1095774007021 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1095774007022 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774007023 Walker A motif; other site 1095774007024 ATP binding site [chemical binding]; other site 1095774007025 Walker B motif; other site 1095774007026 arginine finger; other site 1095774007027 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1095774007028 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1095774007029 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1095774007030 ABC-ATPase subunit interface; other site 1095774007031 dimer interface [polypeptide binding]; other site 1095774007032 putative PBP binding regions; other site 1095774007033 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1095774007034 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1095774007035 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1095774007036 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1095774007037 metal binding site [ion binding]; metal-binding site 1095774007038 putative peptidase; Provisional; Region: PRK11649 1095774007039 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1095774007040 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1095774007041 Peptidase family M23; Region: Peptidase_M23; pfam01551 1095774007042 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1095774007043 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1095774007044 putative acyl-acceptor binding pocket; other site 1095774007045 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 1095774007046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774007047 putative substrate translocation pore; other site 1095774007048 pyruvate kinase; Provisional; Region: PRK05826 1095774007049 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1095774007050 domain interfaces; other site 1095774007051 active site 1095774007052 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1095774007053 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1095774007054 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1095774007055 putative active site [active] 1095774007056 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1095774007057 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1095774007058 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1095774007059 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1095774007060 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1095774007061 active site 1095774007062 intersubunit interface [polypeptide binding]; other site 1095774007063 catalytic residue [active] 1095774007064 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1095774007065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1095774007066 ATP-grasp domain; Region: ATP-grasp; pfam02222 1095774007067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1095774007068 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1095774007069 putative metal binding site [ion binding]; other site 1095774007070 protease 2; Provisional; Region: PRK10115 1095774007071 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1095774007072 exodeoxyribonuclease X; Provisional; Region: PRK07983 1095774007073 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1095774007074 active site 1095774007075 catalytic site [active] 1095774007076 substrate binding site [chemical binding]; other site 1095774007077 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1095774007078 CopC domain; Region: CopC; pfam04234 1095774007079 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1095774007080 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1095774007081 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1095774007082 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774007083 dimer interface [polypeptide binding]; other site 1095774007084 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1095774007085 putative CheW interface [polypeptide binding]; other site 1095774007086 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1095774007087 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774007088 DNA-binding site [nucleotide binding]; DNA binding site 1095774007089 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1095774007090 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1095774007091 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1095774007092 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1095774007093 active site turn [active] 1095774007094 phosphorylation site [posttranslational modification] 1095774007095 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1095774007096 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1095774007097 NAD binding site [chemical binding]; other site 1095774007098 sugar binding site [chemical binding]; other site 1095774007099 divalent metal binding site [ion binding]; other site 1095774007100 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1095774007101 dimer interface [polypeptide binding]; other site 1095774007102 MEKHLA domain; Region: MEKHLA; pfam08670 1095774007103 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1095774007104 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774007105 dimer interface [polypeptide binding]; other site 1095774007106 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1095774007107 putative CheW interface [polypeptide binding]; other site 1095774007108 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1095774007109 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1095774007110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1095774007111 NAD(P) binding site [chemical binding]; other site 1095774007112 active site 1095774007113 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1095774007114 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774007115 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1095774007116 dimerization interface [polypeptide binding]; other site 1095774007117 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774007118 Coenzyme A binding pocket [chemical binding]; other site 1095774007119 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1095774007120 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1095774007121 choline dehydrogenase; Validated; Region: PRK02106 1095774007122 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1095774007123 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1095774007124 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1095774007125 NAD(P) binding site [chemical binding]; other site 1095774007126 catalytic residues [active] 1095774007127 transcriptional regulator BetI; Validated; Region: PRK00767 1095774007128 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1095774007129 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1095774007130 choline transport protein BetT; Provisional; Region: PRK09928 1095774007131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774007132 putative substrate translocation pore; other site 1095774007133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 1095774007134 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 1095774007135 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1095774007136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774007137 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1095774007138 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1095774007139 mce related protein; Region: MCE; pfam02470 1095774007140 mce related protein; Region: MCE; pfam02470 1095774007141 mce related protein; Region: MCE; pfam02470 1095774007142 mce related protein; Region: MCE; pfam02470 1095774007143 mce related protein; Region: MCE; pfam02470 1095774007144 mce related protein; Region: MCE; pfam02470 1095774007145 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1095774007146 Paraquat-inducible protein A; Region: PqiA; pfam04403 1095774007147 Paraquat-inducible protein A; Region: PqiA; pfam04403 1095774007148 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1095774007149 GAF domain; Region: GAF_2; pfam13185 1095774007150 ProP expression regulator; Provisional; Region: PRK04950 1095774007151 ProQ/FINO family; Region: ProQ; pfam04352 1095774007152 carboxy-terminal protease; Provisional; Region: PRK11186 1095774007153 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1095774007154 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1095774007155 protein binding site [polypeptide binding]; other site 1095774007156 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1095774007157 Catalytic dyad [active] 1095774007158 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1095774007159 heat shock protein HtpX; Provisional; Region: PRK05457 1095774007160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774007161 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1095774007162 putative substrate translocation pore; other site 1095774007163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774007164 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1095774007165 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1095774007166 putative DNA binding site [nucleotide binding]; other site 1095774007167 putative Zn2+ binding site [ion binding]; other site 1095774007168 Bacterial transcriptional regulator; Region: IclR; pfam01614 1095774007169 YobH-like protein; Region: YobH; pfam13996 1095774007170 YebO-like protein; Region: YebO; pfam13974 1095774007171 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1095774007172 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1095774007173 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1095774007174 DNA-binding site [nucleotide binding]; DNA binding site 1095774007175 RNA-binding motif; other site 1095774007176 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1095774007177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774007178 S-adenosylmethionine binding site [chemical binding]; other site 1095774007179 hypothetical protein; Provisional; Region: PRK02913 1095774007180 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1095774007181 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1095774007182 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1095774007183 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1095774007184 active pocket/dimerization site; other site 1095774007185 active site 1095774007186 phosphorylation site [posttranslational modification] 1095774007187 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1095774007188 active site 1095774007189 phosphorylation site [posttranslational modification] 1095774007190 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1095774007191 FOG: CBS domain [General function prediction only]; Region: COG0517 1095774007192 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1095774007193 Transporter associated domain; Region: CorC_HlyC; smart01091 1095774007194 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1095774007195 phage resistance protein; Provisional; Region: PRK10551 1095774007196 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1095774007197 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1095774007198 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1095774007199 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1095774007200 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1095774007201 putative active site [active] 1095774007202 putative CoA binding site [chemical binding]; other site 1095774007203 nudix motif; other site 1095774007204 metal binding site [ion binding]; metal-binding site 1095774007205 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1095774007206 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1095774007207 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1095774007208 hypothetical protein; Provisional; Region: PRK05114 1095774007209 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1095774007210 homotrimer interaction site [polypeptide binding]; other site 1095774007211 putative active site [active] 1095774007212 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1095774007213 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1095774007214 DEAD_2; Region: DEAD_2; pfam06733 1095774007215 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1095774007216 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1095774007217 Glycoprotease family; Region: Peptidase_M22; pfam00814 1095774007218 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 1095774007219 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1095774007220 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1095774007221 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1095774007222 acyl-activating enzyme (AAE) consensus motif; other site 1095774007223 putative AMP binding site [chemical binding]; other site 1095774007224 putative active site [active] 1095774007225 putative CoA binding site [chemical binding]; other site 1095774007226 ribonuclease D; Provisional; Region: PRK10829 1095774007227 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1095774007228 catalytic site [active] 1095774007229 putative active site [active] 1095774007230 putative substrate binding site [chemical binding]; other site 1095774007231 HRDC domain; Region: HRDC; pfam00570 1095774007232 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1095774007233 cell division inhibitor MinD; Provisional; Region: PRK10818 1095774007234 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1095774007235 Switch I; other site 1095774007236 Switch II; other site 1095774007237 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1095774007238 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1095774007239 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1095774007240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 1095774007241 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1095774007242 hypothetical protein; Provisional; Region: PRK10691 1095774007243 hypothetical protein; Provisional; Region: PRK05170 1095774007244 disulfide bond formation protein B; Provisional; Region: PRK01749 1095774007245 fatty acid metabolism regulator; Provisional; Region: PRK04984 1095774007246 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774007247 DNA-binding site [nucleotide binding]; DNA binding site 1095774007248 FadR C-terminal domain; Region: FadR_C; pfam07840 1095774007249 SpoVR family protein; Provisional; Region: PRK11767 1095774007250 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1095774007251 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1095774007252 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1095774007253 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1095774007254 alanine racemase; Reviewed; Region: dadX; PRK03646 1095774007255 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1095774007256 active site 1095774007257 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1095774007258 substrate binding site [chemical binding]; other site 1095774007259 catalytic residues [active] 1095774007260 dimer interface [polypeptide binding]; other site 1095774007261 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1095774007262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774007263 putative substrate translocation pore; other site 1095774007264 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 1095774007265 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1095774007266 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 1095774007267 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1095774007268 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1095774007269 TrkA-C domain; Region: TrkA_C; pfam02080 1095774007270 Transporter associated domain; Region: CorC_HlyC; smart01091 1095774007271 hypothetical protein; Provisional; Region: PRK05325 1095774007272 PrkA family serine protein kinase; Provisional; Region: PRK15455 1095774007273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774007274 Walker A motif; other site 1095774007275 ATP binding site [chemical binding]; other site 1095774007276 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1095774007277 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1095774007278 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1095774007279 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1095774007280 active site 1095774007281 catalytic tetrad [active] 1095774007282 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1095774007283 active site 1095774007284 phosphate binding residues; other site 1095774007285 catalytic residues [active] 1095774007286 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1095774007287 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1095774007288 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1095774007289 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1095774007290 SelR domain; Region: SelR; pfam01641 1095774007291 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 1095774007292 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1095774007293 Isochorismatase family; Region: Isochorismatase; pfam00857 1095774007294 catalytic triad [active] 1095774007295 metal binding site [ion binding]; metal-binding site 1095774007296 conserved cis-peptide bond; other site 1095774007297 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1095774007298 active site 1095774007299 homodimer interface [polypeptide binding]; other site 1095774007300 protease 4; Provisional; Region: PRK10949 1095774007301 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1095774007302 tandem repeat interface [polypeptide binding]; other site 1095774007303 oligomer interface [polypeptide binding]; other site 1095774007304 active site residues [active] 1095774007305 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 1095774007306 tandem repeat interface [polypeptide binding]; other site 1095774007307 oligomer interface [polypeptide binding]; other site 1095774007308 active site residues [active] 1095774007309 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1095774007310 putative FMN binding site [chemical binding]; other site 1095774007311 DNA topoisomerase III; Provisional; Region: PRK07726 1095774007312 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1095774007313 active site 1095774007314 putative interdomain interaction site [polypeptide binding]; other site 1095774007315 putative metal-binding site [ion binding]; other site 1095774007316 putative nucleotide binding site [chemical binding]; other site 1095774007317 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1095774007318 domain I; other site 1095774007319 DNA binding groove [nucleotide binding] 1095774007320 phosphate binding site [ion binding]; other site 1095774007321 domain II; other site 1095774007322 domain III; other site 1095774007323 nucleotide binding site [chemical binding]; other site 1095774007324 catalytic site [active] 1095774007325 domain IV; other site 1095774007326 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 1095774007327 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1095774007328 putative catalytic site [active] 1095774007329 putative phosphate binding site [ion binding]; other site 1095774007330 active site 1095774007331 metal binding site A [ion binding]; metal-binding site 1095774007332 DNA binding site [nucleotide binding] 1095774007333 putative AP binding site [nucleotide binding]; other site 1095774007334 putative metal binding site B [ion binding]; other site 1095774007335 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1095774007336 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1095774007337 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1095774007338 putative active site [active] 1095774007339 putative substrate binding site [chemical binding]; other site 1095774007340 putative cosubstrate binding site; other site 1095774007341 catalytic site [active] 1095774007342 hypothetical protein; Provisional; Region: PRK01617 1095774007343 SEC-C motif; Region: SEC-C; pfam02810 1095774007344 hypothetical protein; Provisional; Region: PRK10279 1095774007345 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1095774007346 active site 1095774007347 nucleophile elbow; other site 1095774007348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774007349 active site 1095774007350 response regulator of RpoS; Provisional; Region: PRK10693 1095774007351 phosphorylation site [posttranslational modification] 1095774007352 intermolecular recognition site; other site 1095774007353 dimerization interface [polypeptide binding]; other site 1095774007354 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1095774007355 active site 1095774007356 tetramer interface; other site 1095774007357 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1095774007358 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1095774007359 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1095774007360 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1095774007361 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1095774007362 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1095774007363 putative NAD(P) binding site [chemical binding]; other site 1095774007364 active site 1095774007365 putative substrate binding site [chemical binding]; other site 1095774007366 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1095774007367 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1095774007368 thymidine kinase; Provisional; Region: PRK04296 1095774007369 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1095774007370 ATP binding site [chemical binding]; other site 1095774007371 Walker A motif; other site 1095774007372 Walker B motif; other site 1095774007373 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1095774007374 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1095774007375 putative catalytic cysteine [active] 1095774007376 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1095774007377 putative active site [active] 1095774007378 metal binding site [ion binding]; metal-binding site 1095774007379 hypothetical protein; Provisional; Region: PRK11111 1095774007380 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1095774007381 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1095774007382 peptide binding site [polypeptide binding]; other site 1095774007383 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1095774007384 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1095774007385 peptide binding site [polypeptide binding]; other site 1095774007386 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1095774007387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774007388 dimer interface [polypeptide binding]; other site 1095774007389 conserved gate region; other site 1095774007390 putative PBP binding loops; other site 1095774007391 ABC-ATPase subunit interface; other site 1095774007392 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1095774007393 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1095774007394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774007395 dimer interface [polypeptide binding]; other site 1095774007396 conserved gate region; other site 1095774007397 ABC-ATPase subunit interface; other site 1095774007398 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1095774007399 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1095774007400 Walker A/P-loop; other site 1095774007401 ATP binding site [chemical binding]; other site 1095774007402 Q-loop/lid; other site 1095774007403 ABC transporter signature motif; other site 1095774007404 Walker B; other site 1095774007405 D-loop; other site 1095774007406 H-loop/switch region; other site 1095774007407 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1095774007408 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1095774007409 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1095774007410 Walker A/P-loop; other site 1095774007411 ATP binding site [chemical binding]; other site 1095774007412 Q-loop/lid; other site 1095774007413 ABC transporter signature motif; other site 1095774007414 Walker B; other site 1095774007415 D-loop; other site 1095774007416 H-loop/switch region; other site 1095774007417 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1095774007418 dsDNA-mimic protein; Reviewed; Region: PRK05094 1095774007419 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1095774007420 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1095774007421 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1095774007422 putative active site [active] 1095774007423 catalytic site [active] 1095774007424 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1095774007425 putative active site [active] 1095774007426 catalytic site [active] 1095774007427 YciI-like protein; Reviewed; Region: PRK11370 1095774007428 transport protein TonB; Provisional; Region: PRK10819 1095774007429 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1095774007430 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1095774007431 intracellular septation protein A; Reviewed; Region: PRK00259 1095774007432 hypothetical protein; Provisional; Region: PRK02868 1095774007433 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1095774007434 outer membrane protein W; Provisional; Region: PRK10959 1095774007435 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1095774007436 BON domain; Region: BON; pfam04972 1095774007437 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1095774007438 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1095774007439 substrate binding site [chemical binding]; other site 1095774007440 active site 1095774007441 catalytic residues [active] 1095774007442 heterodimer interface [polypeptide binding]; other site 1095774007443 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1095774007444 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1095774007445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774007446 catalytic residue [active] 1095774007447 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1095774007448 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1095774007449 active site 1095774007450 ribulose/triose binding site [chemical binding]; other site 1095774007451 phosphate binding site [ion binding]; other site 1095774007452 substrate (anthranilate) binding pocket [chemical binding]; other site 1095774007453 product (indole) binding pocket [chemical binding]; other site 1095774007454 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1095774007455 active site 1095774007456 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1095774007457 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1095774007458 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1095774007459 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1095774007460 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1095774007461 glutamine binding [chemical binding]; other site 1095774007462 catalytic triad [active] 1095774007463 anthranilate synthase component I; Provisional; Region: PRK13564 1095774007464 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1095774007465 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1095774007466 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1095774007467 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1095774007468 active site 1095774007469 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1095774007470 hypothetical protein; Provisional; Region: PRK11630 1095774007471 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1095774007472 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1095774007473 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1095774007474 RNA binding surface [nucleotide binding]; other site 1095774007475 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1095774007476 probable active site [active] 1095774007477 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1095774007478 Citrate transporter; Region: CitMHS; pfam03600 1095774007479 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1095774007480 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 1095774007481 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1095774007482 homodimer interface [polypeptide binding]; other site 1095774007483 Walker A motif; other site 1095774007484 ATP binding site [chemical binding]; other site 1095774007485 hydroxycobalamin binding site [chemical binding]; other site 1095774007486 Walker B motif; other site 1095774007487 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1095774007488 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1095774007489 NAD(P) binding site [chemical binding]; other site 1095774007490 active site 1095774007491 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1095774007492 putative inner membrane peptidase; Provisional; Region: PRK11778 1095774007493 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1095774007494 tandem repeat interface [polypeptide binding]; other site 1095774007495 oligomer interface [polypeptide binding]; other site 1095774007496 active site residues [active] 1095774007497 hypothetical protein; Provisional; Region: PRK11037 1095774007498 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1095774007499 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1095774007500 active site 1095774007501 interdomain interaction site; other site 1095774007502 putative metal-binding site [ion binding]; other site 1095774007503 nucleotide binding site [chemical binding]; other site 1095774007504 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1095774007505 domain I; other site 1095774007506 DNA binding groove [nucleotide binding] 1095774007507 phosphate binding site [ion binding]; other site 1095774007508 domain II; other site 1095774007509 domain III; other site 1095774007510 nucleotide binding site [chemical binding]; other site 1095774007511 catalytic site [active] 1095774007512 domain IV; other site 1095774007513 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1095774007514 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1095774007515 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1095774007516 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1095774007517 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1095774007518 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774007519 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1095774007520 substrate binding site [chemical binding]; other site 1095774007521 putative dimerization interface [polypeptide binding]; other site 1095774007522 aconitate hydratase; Validated; Region: PRK09277 1095774007523 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1095774007524 substrate binding site [chemical binding]; other site 1095774007525 ligand binding site [chemical binding]; other site 1095774007526 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1095774007527 substrate binding site [chemical binding]; other site 1095774007528 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1095774007529 dimerization interface [polypeptide binding]; other site 1095774007530 active site 1095774007531 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1095774007532 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1095774007533 active site 1095774007534 Predicted membrane protein [Function unknown]; Region: COG3771 1095774007535 tetratricopeptide repeat protein; Provisional; Region: PRK11788 1095774007536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1095774007537 TPR motif; other site 1095774007538 binding surface 1095774007539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1095774007540 binding surface 1095774007541 TPR motif; other site 1095774007542 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1095774007543 active site 1095774007544 dimer interface [polypeptide binding]; other site 1095774007545 translation initiation factor Sui1; Validated; Region: PRK06824 1095774007546 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1095774007547 putative rRNA binding site [nucleotide binding]; other site 1095774007548 lipoprotein; Provisional; Region: PRK10540 1095774007549 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1095774007550 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1095774007551 intersubunit interface [polypeptide binding]; other site 1095774007552 active site 1095774007553 Zn2+ binding site [ion binding]; other site 1095774007554 enoyl-CoA hydratase; Validated; Region: PRK08788 1095774007555 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1095774007556 substrate binding site [chemical binding]; other site 1095774007557 oxyanion hole (OAH) forming residues; other site 1095774007558 trimer interface [polypeptide binding]; other site 1095774007559 RNase II stability modulator; Provisional; Region: PRK10060 1095774007560 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1095774007561 putative active site [active] 1095774007562 heme pocket [chemical binding]; other site 1095774007563 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1095774007564 metal binding site [ion binding]; metal-binding site 1095774007565 active site 1095774007566 I-site; other site 1095774007567 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1095774007568 Uncharacterized small protein [Function unknown]; Region: COG2879 1095774007569 carbon starvation protein A; Provisional; Region: PRK15015 1095774007570 Carbon starvation protein CstA; Region: CstA; pfam02554 1095774007571 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1095774007572 exoribonuclease II; Provisional; Region: PRK05054 1095774007573 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1095774007574 RNB domain; Region: RNB; pfam00773 1095774007575 S1 RNA binding domain; Region: S1; pfam00575 1095774007576 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1095774007577 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1095774007578 putative molybdopterin cofactor binding site [chemical binding]; other site 1095774007579 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1095774007580 putative molybdopterin cofactor binding site; other site 1095774007581 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1095774007582 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 1095774007583 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1095774007584 active site turn [active] 1095774007585 phosphorylation site [posttranslational modification] 1095774007586 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1095774007587 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1095774007588 Terminase small subunit; Region: Terminase_2; pfam03592 1095774007589 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1095774007590 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774007591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774007592 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1095774007593 dimerization interface [polypeptide binding]; other site 1095774007594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 1095774007595 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1095774007596 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1095774007597 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1095774007598 NAD binding site [chemical binding]; other site 1095774007599 homotetramer interface [polypeptide binding]; other site 1095774007600 homodimer interface [polypeptide binding]; other site 1095774007601 substrate binding site [chemical binding]; other site 1095774007602 active site 1095774007603 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1095774007604 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1095774007605 Walker A/P-loop; other site 1095774007606 ATP binding site [chemical binding]; other site 1095774007607 Q-loop/lid; other site 1095774007608 ABC transporter signature motif; other site 1095774007609 Walker B; other site 1095774007610 D-loop; other site 1095774007611 H-loop/switch region; other site 1095774007612 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1095774007613 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1095774007614 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1095774007615 Walker A/P-loop; other site 1095774007616 ATP binding site [chemical binding]; other site 1095774007617 Q-loop/lid; other site 1095774007618 ABC transporter signature motif; other site 1095774007619 Walker B; other site 1095774007620 D-loop; other site 1095774007621 H-loop/switch region; other site 1095774007622 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1095774007623 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1095774007624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774007625 dimer interface [polypeptide binding]; other site 1095774007626 conserved gate region; other site 1095774007627 putative PBP binding loops; other site 1095774007628 ABC-ATPase subunit interface; other site 1095774007629 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1095774007630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774007631 dimer interface [polypeptide binding]; other site 1095774007632 conserved gate region; other site 1095774007633 putative PBP binding loops; other site 1095774007634 ABC-ATPase subunit interface; other site 1095774007635 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1095774007636 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1095774007637 peptide binding site [polypeptide binding]; other site 1095774007638 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1095774007639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774007640 Walker A motif; other site 1095774007641 ATP binding site [chemical binding]; other site 1095774007642 Walker B motif; other site 1095774007643 arginine finger; other site 1095774007644 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1095774007645 phage shock protein PspA; Provisional; Region: PRK10698 1095774007646 phage shock protein B; Provisional; Region: pspB; PRK09458 1095774007647 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1095774007648 phage shock protein C; Region: phageshock_pspC; TIGR02978 1095774007649 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 1095774007650 Predicted ATPase [General function prediction only]; Region: COG3106 1095774007651 hypothetical protein; Provisional; Region: PRK05415 1095774007652 Domain of unknown function (DUF697); Region: DUF697; cl12064 1095774007653 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1095774007654 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1095774007655 putative aromatic amino acid binding site; other site 1095774007656 PAS domain; Region: PAS; smart00091 1095774007657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774007658 Walker A motif; other site 1095774007659 ATP binding site [chemical binding]; other site 1095774007660 Walker B motif; other site 1095774007661 arginine finger; other site 1095774007662 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1095774007663 dimer interface [polypeptide binding]; other site 1095774007664 catalytic triad [active] 1095774007665 peroxidatic and resolving cysteines [active] 1095774007666 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1095774007667 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1095774007668 active site 1095774007669 murein peptide amidase A; Provisional; Region: PRK10602 1095774007670 active site 1095774007671 Zn binding site [ion binding]; other site 1095774007672 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1095774007673 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1095774007674 peptide binding site [polypeptide binding]; other site 1095774007675 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1095774007676 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1095774007677 Cl binding site [ion binding]; other site 1095774007678 oligomer interface [polypeptide binding]; other site 1095774007679 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1095774007680 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1095774007681 Ligand Binding Site [chemical binding]; other site 1095774007682 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 1095774007683 MgtC family; Region: MgtC; pfam02308 1095774007684 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1095774007685 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1095774007686 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1095774007687 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1095774007688 putative ligand binding site [chemical binding]; other site 1095774007689 putative NAD binding site [chemical binding]; other site 1095774007690 catalytic site [active] 1095774007691 hypothetical protein; Provisional; Region: PRK10695 1095774007692 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1095774007693 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 1095774007694 azoreductase; Reviewed; Region: PRK00170 1095774007695 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1095774007696 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1095774007697 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1095774007698 ATP binding site [chemical binding]; other site 1095774007699 putative Mg++ binding site [ion binding]; other site 1095774007700 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1095774007701 nucleotide binding region [chemical binding]; other site 1095774007702 ATP-binding site [chemical binding]; other site 1095774007703 Helicase associated domain (HA2); Region: HA2; pfam04408 1095774007704 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1095774007705 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1095774007706 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1095774007707 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1095774007708 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1095774007709 active site 1095774007710 Zn binding site [ion binding]; other site 1095774007711 sensor protein RstB; Provisional; Region: PRK10604 1095774007712 HAMP domain; Region: HAMP; pfam00672 1095774007713 dimerization interface [polypeptide binding]; other site 1095774007714 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1095774007715 dimer interface [polypeptide binding]; other site 1095774007716 phosphorylation site [posttranslational modification] 1095774007717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774007718 ATP binding site [chemical binding]; other site 1095774007719 Mg2+ binding site [ion binding]; other site 1095774007720 G-X-G motif; other site 1095774007721 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1095774007722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774007723 active site 1095774007724 phosphorylation site [posttranslational modification] 1095774007725 intermolecular recognition site; other site 1095774007726 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1095774007727 DNA binding site [nucleotide binding] 1095774007728 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1095774007729 Spore germination protein; Region: Spore_permease; cl17796 1095774007730 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1095774007731 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1095774007732 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1095774007733 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1095774007734 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1095774007735 ligand binding site [chemical binding]; other site 1095774007736 homodimer interface [polypeptide binding]; other site 1095774007737 NAD(P) binding site [chemical binding]; other site 1095774007738 trimer interface B [polypeptide binding]; other site 1095774007739 trimer interface A [polypeptide binding]; other site 1095774007740 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1095774007741 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1095774007742 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1095774007743 universal stress protein UspE; Provisional; Region: PRK11175 1095774007744 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1095774007745 Ligand Binding Site [chemical binding]; other site 1095774007746 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1095774007747 Ligand Binding Site [chemical binding]; other site 1095774007748 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1095774007749 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1095774007750 ligand binding site [chemical binding]; other site 1095774007751 flexible hinge region; other site 1095774007752 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1095774007753 putative switch regulator; other site 1095774007754 non-specific DNA interactions [nucleotide binding]; other site 1095774007755 DNA binding site [nucleotide binding] 1095774007756 sequence specific DNA binding site [nucleotide binding]; other site 1095774007757 putative cAMP binding site [chemical binding]; other site 1095774007758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1095774007759 Smr domain; Region: Smr; pfam01713 1095774007760 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1095774007761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774007762 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1095774007763 dimerization interface [polypeptide binding]; other site 1095774007764 benzoate transport; Region: 2A0115; TIGR00895 1095774007765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774007766 putative substrate translocation pore; other site 1095774007767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774007768 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1095774007769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1095774007770 Predicted membrane protein [Function unknown]; Region: COG2259 1095774007771 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1095774007772 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1095774007773 substrate binding pocket [chemical binding]; other site 1095774007774 catalytic triad [active] 1095774007775 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1095774007776 HAMP domain; Region: HAMP; pfam00672 1095774007777 dimerization interface [polypeptide binding]; other site 1095774007778 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774007779 dimer interface [polypeptide binding]; other site 1095774007780 putative CheW interface [polypeptide binding]; other site 1095774007781 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1095774007782 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1095774007783 metal binding site [ion binding]; metal-binding site 1095774007784 dimer interface [polypeptide binding]; other site 1095774007785 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1095774007786 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1095774007787 peptide binding site [polypeptide binding]; other site 1095774007788 hypothetical protein; Provisional; Region: PRK11019 1095774007789 putative arabinose transporter; Provisional; Region: PRK03545 1095774007790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774007791 putative substrate translocation pore; other site 1095774007792 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1095774007793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774007794 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1095774007795 putative substrate translocation pore; other site 1095774007796 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1095774007797 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774007798 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1095774007799 dimerization interface [polypeptide binding]; other site 1095774007800 substrate binding pocket [chemical binding]; other site 1095774007801 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1095774007802 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1095774007803 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1095774007804 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1095774007805 AAA domain; Region: AAA_26; pfam13500 1095774007806 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1095774007807 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1095774007808 Walker A/P-loop; other site 1095774007809 ATP binding site [chemical binding]; other site 1095774007810 Q-loop/lid; other site 1095774007811 ABC transporter signature motif; other site 1095774007812 Walker B; other site 1095774007813 D-loop; other site 1095774007814 H-loop/switch region; other site 1095774007815 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 1095774007816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774007817 dimer interface [polypeptide binding]; other site 1095774007818 conserved gate region; other site 1095774007819 ABC-ATPase subunit interface; other site 1095774007820 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1095774007821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774007822 dimer interface [polypeptide binding]; other site 1095774007823 conserved gate region; other site 1095774007824 putative PBP binding loops; other site 1095774007825 ABC-ATPase subunit interface; other site 1095774007826 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1095774007827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774007828 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1095774007829 hypothetical protein; Provisional; Region: PRK13659 1095774007830 hypothetical protein; Provisional; Region: PRK02237 1095774007831 malonic semialdehyde reductase; Provisional; Region: PRK10538 1095774007832 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1095774007833 putative NAD(P) binding site [chemical binding]; other site 1095774007834 homodimer interface [polypeptide binding]; other site 1095774007835 homotetramer interface [polypeptide binding]; other site 1095774007836 active site 1095774007837 guanine deaminase; Provisional; Region: PRK09228 1095774007838 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1095774007839 active site 1095774007840 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1095774007841 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1095774007842 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1095774007843 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 1095774007844 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1095774007845 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1095774007846 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1095774007847 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1095774007848 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1095774007849 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 1095774007850 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1095774007851 active site 1095774007852 Zn binding site [ion binding]; other site 1095774007853 hypothetical protein; Provisional; Region: PRK07236 1095774007854 FAD binding domain; Region: FAD_binding_3; pfam01494 1095774007855 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1095774007856 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1095774007857 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 1095774007858 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1095774007859 short chain dehydrogenase; Provisional; Region: PRK06701 1095774007860 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1095774007861 NAD binding site [chemical binding]; other site 1095774007862 metal binding site [ion binding]; metal-binding site 1095774007863 active site 1095774007864 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1095774007865 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1095774007866 DNA binding residues [nucleotide binding] 1095774007867 dimerization interface [polypeptide binding]; other site 1095774007868 Autoinducer synthetase; Region: Autoind_synth; pfam00765 1095774007869 putative symporter YagG; Provisional; Region: PRK09669 1095774007870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774007871 putative substrate translocation pore; other site 1095774007872 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1095774007873 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1095774007874 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1095774007875 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774007876 Coenzyme A binding pocket [chemical binding]; other site 1095774007877 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1095774007878 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1095774007879 non-specific DNA binding site [nucleotide binding]; other site 1095774007880 salt bridge; other site 1095774007881 sequence-specific DNA binding site [nucleotide binding]; other site 1095774007882 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1095774007883 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1095774007884 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1095774007885 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1095774007886 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1095774007887 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1095774007888 potassium uptake protein; Region: kup; TIGR00794 1095774007889 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1095774007890 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774007891 dimer interface [polypeptide binding]; other site 1095774007892 putative CheW interface [polypeptide binding]; other site 1095774007893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 1095774007894 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1095774007895 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1095774007896 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1095774007897 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1095774007898 DNA binding residues [nucleotide binding] 1095774007899 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1095774007900 Fasciclin domain; Region: Fasciclin; pfam02469 1095774007901 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1095774007902 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774007903 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774007904 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1095774007905 dimerization interface [polypeptide binding]; other site 1095774007906 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1095774007907 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 1095774007908 dimer interface [polypeptide binding]; other site 1095774007909 active site 1095774007910 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1095774007911 substrate binding site [chemical binding]; other site 1095774007912 catalytic residue [active] 1095774007913 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1095774007914 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1095774007915 NAD(P) binding site [chemical binding]; other site 1095774007916 catalytic residues [active] 1095774007917 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1095774007918 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1095774007919 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1095774007920 homotrimer interaction site [polypeptide binding]; other site 1095774007921 putative active site [active] 1095774007922 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1095774007923 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774007924 DNA-binding site [nucleotide binding]; DNA binding site 1095774007925 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1095774007926 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1095774007927 DNA-binding site [nucleotide binding]; DNA binding site 1095774007928 FCD domain; Region: FCD; pfam07729 1095774007929 hypothetical protein; Provisional; Region: PRK06102 1095774007930 Amidase; Region: Amidase; cl11426 1095774007931 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 1095774007932 active site 1095774007933 catalytic site [active] 1095774007934 Zn binding site [ion binding]; other site 1095774007935 tetramer interface [polypeptide binding]; other site 1095774007936 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1095774007937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774007938 benzoate transport; Region: 2A0115; TIGR00895 1095774007939 putative substrate translocation pore; other site 1095774007940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1095774007941 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1095774007942 NAD(P) binding site [chemical binding]; other site 1095774007943 active site 1095774007944 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1095774007945 classical (c) SDRs; Region: SDR_c; cd05233 1095774007946 NAD(P) binding site [chemical binding]; other site 1095774007947 active site 1095774007948 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1095774007949 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1095774007950 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1095774007951 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1095774007952 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1095774007953 nudix motif; other site 1095774007954 NlpC/P60 family; Region: NLPC_P60; pfam00877 1095774007955 magnesium transport protein MgtC; Provisional; Region: PRK15385 1095774007956 MgtC family; Region: MgtC; pfam02308 1095774007957 putative oxidoreductase; Provisional; Region: PRK09939 1095774007958 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1095774007959 putative molybdopterin cofactor binding site [chemical binding]; other site 1095774007960 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1095774007961 putative molybdopterin cofactor binding site; other site 1095774007962 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 1095774007963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1095774007964 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1095774007965 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774007966 Coenzyme A binding pocket [chemical binding]; other site 1095774007967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774007968 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1095774007969 putative substrate translocation pore; other site 1095774007970 transcriptional regulator MalT; Provisional; Region: PRK04841 1095774007971 AAA ATPase domain; Region: AAA_16; pfam13191 1095774007972 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1095774007973 DNA binding residues [nucleotide binding] 1095774007974 dimerization interface [polypeptide binding]; other site 1095774007975 maltodextrin phosphorylase; Provisional; Region: PRK14985 1095774007976 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1095774007977 active site pocket [active] 1095774007978 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1095774007979 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1095774007980 Helix-turn-helix domain; Region: HTH_18; pfam12833 1095774007981 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774007982 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1095774007983 PGAP1-like protein; Region: PGAP1; pfam07819 1095774007984 maltose regulon periplasmic protein; Provisional; Region: PRK10564 1095774007985 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1095774007986 trimer interface; other site 1095774007987 sugar binding site [chemical binding]; other site 1095774007988 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1095774007989 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1095774007990 Walker A/P-loop; other site 1095774007991 ATP binding site [chemical binding]; other site 1095774007992 Q-loop/lid; other site 1095774007993 ABC transporter signature motif; other site 1095774007994 Walker B; other site 1095774007995 D-loop; other site 1095774007996 H-loop/switch region; other site 1095774007997 TOBE domain; Region: TOBE_2; pfam08402 1095774007998 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1095774007999 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1095774008000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774008001 dimer interface [polypeptide binding]; other site 1095774008002 conserved gate region; other site 1095774008003 putative PBP binding loops; other site 1095774008004 ABC-ATPase subunit interface; other site 1095774008005 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1095774008006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774008007 dimer interface [polypeptide binding]; other site 1095774008008 conserved gate region; other site 1095774008009 putative PBP binding loops; other site 1095774008010 ABC-ATPase subunit interface; other site 1095774008011 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1095774008012 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1095774008013 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1095774008014 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1095774008015 active site 1095774008016 dimer interface [polypeptide binding]; other site 1095774008017 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1095774008018 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1095774008019 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1095774008020 active site 1095774008021 FMN binding site [chemical binding]; other site 1095774008022 substrate binding site [chemical binding]; other site 1095774008023 homotetramer interface [polypeptide binding]; other site 1095774008024 catalytic residue [active] 1095774008025 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1095774008026 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1095774008027 active site 1095774008028 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1095774008029 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1095774008030 Xanthomonas XOO_2897-like deaminase; Region: XOO_2897-deam; pfam14440 1095774008031 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 1095774008032 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333 1095774008033 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753 1095774008034 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1095774008035 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1095774008036 dimerization interface [polypeptide binding]; other site 1095774008037 putative DNA binding site [nucleotide binding]; other site 1095774008038 putative Zn2+ binding site [ion binding]; other site 1095774008039 arsenical pump membrane protein; Provisional; Region: PRK15445 1095774008040 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1095774008041 transmembrane helices; other site 1095774008042 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1095774008043 ArsC family; Region: ArsC; pfam03960 1095774008044 catalytic residues [active] 1095774008045 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1095774008046 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1095774008047 metal binding site [ion binding]; metal-binding site 1095774008048 putative dimer interface [polypeptide binding]; other site 1095774008049 hypothetical protein; Provisional; Region: PRK10519 1095774008050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1095774008051 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774008052 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774008053 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_5; cd08426 1095774008054 putative dimerization interface [polypeptide binding]; other site 1095774008055 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1095774008056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1095774008057 NAD(P) binding site [chemical binding]; other site 1095774008058 active site 1095774008059 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774008060 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774008061 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1095774008062 putative effector binding pocket; other site 1095774008063 putative dimerization interface [polypeptide binding]; other site 1095774008064 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1095774008065 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1095774008066 active site 1095774008067 metal binding site [ion binding]; metal-binding site 1095774008068 maltose O-acetyltransferase; Provisional; Region: PRK10092 1095774008069 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1095774008070 active site 1095774008071 substrate binding site [chemical binding]; other site 1095774008072 trimer interface [polypeptide binding]; other site 1095774008073 CoA binding site [chemical binding]; other site 1095774008074 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1095774008075 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774008076 DNA binding site [nucleotide binding] 1095774008077 domain linker motif; other site 1095774008078 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1095774008079 dimerization interface [polypeptide binding]; other site 1095774008080 ligand binding site [chemical binding]; other site 1095774008081 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1095774008082 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774008083 substrate binding pocket [chemical binding]; other site 1095774008084 membrane-bound complex binding site; other site 1095774008085 hinge residues; other site 1095774008086 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1095774008087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774008088 dimer interface [polypeptide binding]; other site 1095774008089 conserved gate region; other site 1095774008090 putative PBP binding loops; other site 1095774008091 ABC-ATPase subunit interface; other site 1095774008092 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1095774008093 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1095774008094 Walker A/P-loop; other site 1095774008095 ATP binding site [chemical binding]; other site 1095774008096 Q-loop/lid; other site 1095774008097 ABC transporter signature motif; other site 1095774008098 Walker B; other site 1095774008099 D-loop; other site 1095774008100 H-loop/switch region; other site 1095774008101 putative oxidoreductase; Provisional; Region: PRK11579 1095774008102 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1095774008103 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1095774008104 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1095774008105 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1095774008106 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1095774008107 NAD(P) binding site [chemical binding]; other site 1095774008108 substrate binding site [chemical binding]; other site 1095774008109 dimer interface [polypeptide binding]; other site 1095774008110 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1095774008111 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1095774008112 substrate binding site [chemical binding]; other site 1095774008113 ATP binding site [chemical binding]; other site 1095774008114 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 1095774008115 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1095774008116 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1095774008117 putative active site [active] 1095774008118 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1095774008119 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1095774008120 TM-ABC transporter signature motif; other site 1095774008121 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1095774008122 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1095774008123 Walker A/P-loop; other site 1095774008124 ATP binding site [chemical binding]; other site 1095774008125 Q-loop/lid; other site 1095774008126 ABC transporter signature motif; other site 1095774008127 Walker B; other site 1095774008128 D-loop; other site 1095774008129 H-loop/switch region; other site 1095774008130 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1095774008131 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 1095774008132 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1095774008133 ligand binding site [chemical binding]; other site 1095774008134 dimerization interface [polypeptide binding]; other site 1095774008135 zinc binding site [ion binding]; other site 1095774008136 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1095774008137 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1095774008138 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1095774008139 tetramer interface [polypeptide binding]; other site 1095774008140 heme binding pocket [chemical binding]; other site 1095774008141 NADPH binding site [chemical binding]; other site 1095774008142 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 1095774008143 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1095774008144 trimer interface [polypeptide binding]; other site 1095774008145 active site 1095774008146 substrate binding site [chemical binding]; other site 1095774008147 CoA binding site [chemical binding]; other site 1095774008148 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1095774008149 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1095774008150 AAA domain; Region: AAA_17; pfam13207 1095774008151 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1095774008152 active site 1095774008153 phosphorylation site [posttranslational modification] 1095774008154 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1095774008155 intersubunit interface [polypeptide binding]; other site 1095774008156 active site 1095774008157 zinc binding site [ion binding]; other site 1095774008158 Na+ binding site [ion binding]; other site 1095774008159 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1095774008160 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1095774008161 active site 1095774008162 P-loop; other site 1095774008163 phosphorylation site [posttranslational modification] 1095774008164 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1095774008165 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1095774008166 active site 1095774008167 ADP/pyrophosphate binding site [chemical binding]; other site 1095774008168 dimerization interface [polypeptide binding]; other site 1095774008169 allosteric effector site; other site 1095774008170 fructose-1,6-bisphosphate binding site; other site 1095774008171 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1095774008172 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 1095774008173 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1095774008174 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1095774008175 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 1095774008176 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1095774008177 FeS/SAM binding site; other site 1095774008178 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1095774008179 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1095774008180 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 1095774008181 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1095774008182 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 1095774008183 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 1095774008184 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1095774008185 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1095774008186 active site 1095774008187 dimer interface [polypeptide binding]; other site 1095774008188 2-isopropylmalate synthase; Validated; Region: PRK03739 1095774008189 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1095774008190 active site 1095774008191 catalytic residues [active] 1095774008192 metal binding site [ion binding]; metal-binding site 1095774008193 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1095774008194 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1095774008195 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1095774008196 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774008197 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1095774008198 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1095774008199 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1095774008200 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1095774008201 N-terminal plug; other site 1095774008202 ligand-binding site [chemical binding]; other site 1095774008203 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1095774008204 oligomeric interface; other site 1095774008205 homodimer interface [polypeptide binding]; other site 1095774008206 putative active site [active] 1095774008207 Isochorismatase family; Region: Isochorismatase; pfam00857 1095774008208 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1095774008209 catalytic triad [active] 1095774008210 conserved cis-peptide bond; other site 1095774008211 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1095774008212 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1095774008213 non-specific DNA binding site [nucleotide binding]; other site 1095774008214 salt bridge; other site 1095774008215 sequence-specific DNA binding site [nucleotide binding]; other site 1095774008216 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1095774008217 benzoate transporter; Region: benE; TIGR00843 1095774008218 Virulence factor SrfB; Region: SrfB; pfam07520 1095774008219 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 1095774008220 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 1095774008221 RNAase interaction site [polypeptide binding]; other site 1095774008222 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 1095774008223 active site 1095774008224 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1095774008225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774008226 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1095774008227 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1095774008228 HlyD family secretion protein; Region: HlyD_3; pfam13437 1095774008229 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1095774008230 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1095774008231 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1095774008232 catalytic site [active] 1095774008233 Predicted transcriptional regulator [Transcription]; Region: COG1959 1095774008234 Transcriptional regulator; Region: Rrf2; pfam02082 1095774008235 Transcriptional regulator; Region: Rrf2; cl17282 1095774008236 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1095774008237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774008238 putative substrate translocation pore; other site 1095774008239 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1095774008240 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1095774008241 Class II fumarases; Region: Fumarase_classII; cd01362 1095774008242 active site 1095774008243 tetramer interface [polypeptide binding]; other site 1095774008244 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1095774008245 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1095774008246 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1095774008247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1095774008248 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1095774008249 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1095774008250 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1095774008251 active site 1095774008252 purine riboside binding site [chemical binding]; other site 1095774008253 putative oxidoreductase; Provisional; Region: PRK11579 1095774008254 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1095774008255 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1095774008256 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1095774008257 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1095774008258 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774008259 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774008260 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1095774008261 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1095774008262 TM-ABC transporter signature motif; other site 1095774008263 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1095774008264 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1095774008265 Walker A/P-loop; other site 1095774008266 ATP binding site [chemical binding]; other site 1095774008267 Q-loop/lid; other site 1095774008268 ABC transporter signature motif; other site 1095774008269 Walker B; other site 1095774008270 D-loop; other site 1095774008271 H-loop/switch region; other site 1095774008272 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1095774008273 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1095774008274 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1095774008275 ligand binding site [chemical binding]; other site 1095774008276 ribulokinase; Provisional; Region: PRK04123 1095774008277 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1095774008278 N- and C-terminal domain interface [polypeptide binding]; other site 1095774008279 active site 1095774008280 MgATP binding site [chemical binding]; other site 1095774008281 catalytic site [active] 1095774008282 metal binding site [ion binding]; metal-binding site 1095774008283 carbohydrate binding site [chemical binding]; other site 1095774008284 homodimer interface [polypeptide binding]; other site 1095774008285 L-arabinose isomerase; Provisional; Region: PRK02929 1095774008286 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1095774008287 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1095774008288 trimer interface [polypeptide binding]; other site 1095774008289 putative substrate binding site [chemical binding]; other site 1095774008290 putative metal binding site [ion binding]; other site 1095774008291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1095774008292 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1095774008293 NAD(P) binding site [chemical binding]; other site 1095774008294 active site 1095774008295 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774008296 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774008297 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1095774008298 putative substrate binding pocket [chemical binding]; other site 1095774008299 putative dimerization interface [polypeptide binding]; other site 1095774008300 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1095774008301 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1095774008302 active site 1095774008303 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1095774008304 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1095774008305 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1095774008306 CGNR zinc finger; Region: zf-CGNR; pfam11706 1095774008307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1095774008308 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1095774008309 DNA-binding site [nucleotide binding]; DNA binding site 1095774008310 RNA-binding motif; other site 1095774008311 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1095774008312 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774008313 motif II; other site 1095774008314 Phosphotransferase enzyme family; Region: APH; pfam01636 1095774008315 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1095774008316 active site 1095774008317 ATP binding site [chemical binding]; other site 1095774008318 substrate binding site [chemical binding]; other site 1095774008319 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1095774008320 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1095774008321 inhibitor-cofactor binding pocket; inhibition site 1095774008322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774008323 catalytic residue [active] 1095774008324 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1095774008325 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1095774008326 putative DNA binding site [nucleotide binding]; other site 1095774008327 putative Zn2+ binding site [ion binding]; other site 1095774008328 AsnC family; Region: AsnC_trans_reg; pfam01037 1095774008329 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1095774008330 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1095774008331 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1095774008332 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1095774008333 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1095774008334 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1095774008335 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1095774008336 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1095774008337 putative NAD(P) binding site [chemical binding]; other site 1095774008338 Cupin; Region: Cupin_6; pfam12852 1095774008339 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774008340 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1095774008341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774008342 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1095774008343 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1095774008344 Na binding site [ion binding]; other site 1095774008345 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1095774008346 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1095774008347 amidase catalytic site [active] 1095774008348 Zn binding residues [ion binding]; other site 1095774008349 substrate binding site [chemical binding]; other site 1095774008350 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1095774008351 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1095774008352 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1095774008353 DNA binding residues [nucleotide binding] 1095774008354 dimerization interface [polypeptide binding]; other site 1095774008355 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1095774008356 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1095774008357 DNA binding residues [nucleotide binding] 1095774008358 dimerization interface [polypeptide binding]; other site 1095774008359 putative fimbrial chaperone protein; Provisional; Region: PRK09918 1095774008360 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1095774008361 PapC N-terminal domain; Region: PapC_N; pfam13954 1095774008362 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1095774008363 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 1095774008364 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1095774008365 DNA binding site [nucleotide binding] 1095774008366 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1095774008367 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1095774008368 metal binding site [ion binding]; metal-binding site 1095774008369 active site 1095774008370 I-site; other site 1095774008371 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1095774008372 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1095774008373 TM-ABC transporter signature motif; other site 1095774008374 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1095774008375 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1095774008376 TM-ABC transporter signature motif; other site 1095774008377 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1095774008378 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1095774008379 Walker A/P-loop; other site 1095774008380 ATP binding site [chemical binding]; other site 1095774008381 Q-loop/lid; other site 1095774008382 ABC transporter signature motif; other site 1095774008383 Walker B; other site 1095774008384 D-loop; other site 1095774008385 H-loop/switch region; other site 1095774008386 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1095774008387 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1095774008388 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1095774008389 putative ligand binding site [chemical binding]; other site 1095774008390 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 1095774008391 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1095774008392 electron transport complex protein RsxA; Provisional; Region: PRK05151 1095774008393 electron transport complex protein RnfB; Provisional; Region: PRK05113 1095774008394 Putative Fe-S cluster; Region: FeS; cl17515 1095774008395 4Fe-4S binding domain; Region: Fer4; pfam00037 1095774008396 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 1095774008397 SLBB domain; Region: SLBB; pfam10531 1095774008398 ferredoxin; Provisional; Region: PRK06991 1095774008399 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1095774008400 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1095774008401 electron transport complex protein RnfG; Validated; Region: PRK01908 1095774008402 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1095774008403 endonuclease III; Provisional; Region: PRK10702 1095774008404 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1095774008405 minor groove reading motif; other site 1095774008406 helix-hairpin-helix signature motif; other site 1095774008407 substrate binding pocket [chemical binding]; other site 1095774008408 active site 1095774008409 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1095774008410 hypothetical protein; Validated; Region: PRK06186 1095774008411 conserved cys residue [active] 1095774008412 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1095774008413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774008414 putative substrate translocation pore; other site 1095774008415 glutathionine S-transferase; Provisional; Region: PRK10542 1095774008416 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1095774008417 C-terminal domain interface [polypeptide binding]; other site 1095774008418 GSH binding site (G-site) [chemical binding]; other site 1095774008419 dimer interface [polypeptide binding]; other site 1095774008420 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1095774008421 dimer interface [polypeptide binding]; other site 1095774008422 N-terminal domain interface [polypeptide binding]; other site 1095774008423 substrate binding pocket (H-site) [chemical binding]; other site 1095774008424 pyridoxamine kinase; Validated; Region: PRK05756 1095774008425 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1095774008426 dimer interface [polypeptide binding]; other site 1095774008427 pyridoxal binding site [chemical binding]; other site 1095774008428 ATP binding site [chemical binding]; other site 1095774008429 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1095774008430 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1095774008431 active site 1095774008432 HIGH motif; other site 1095774008433 dimer interface [polypeptide binding]; other site 1095774008434 KMSKS motif; other site 1095774008435 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1095774008436 RNA binding surface [nucleotide binding]; other site 1095774008437 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1095774008438 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1095774008439 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1095774008440 lysozyme inhibitor; Provisional; Region: PRK11372 1095774008441 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1095774008442 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1095774008443 active site 1095774008444 homotetramer interface [polypeptide binding]; other site 1095774008445 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1095774008446 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1095774008447 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 1095774008448 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1095774008449 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1095774008450 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1095774008451 chaperone protein HchA; Provisional; Region: PRK04155 1095774008452 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1095774008453 conserved cys residue [active] 1095774008454 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1095774008455 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1095774008456 active site 1095774008457 DNA binding site [nucleotide binding] 1095774008458 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1095774008459 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1095774008460 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1095774008461 Catalytic site [active] 1095774008462 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1095774008463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774008464 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1095774008465 dimerization interface [polypeptide binding]; other site 1095774008466 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1095774008467 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 1095774008468 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1095774008469 conserved cys residue [active] 1095774008470 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1095774008471 UV-endonuclease UvdE; Region: UvdE; cl10036 1095774008472 hydroperoxidase II; Provisional; Region: katE; PRK11249 1095774008473 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1095774008474 tetramer interface [polypeptide binding]; other site 1095774008475 heme binding pocket [chemical binding]; other site 1095774008476 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1095774008477 domain interactions; other site 1095774008478 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1095774008479 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1095774008480 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1095774008481 catalytic site [active] 1095774008482 active site 1095774008483 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1095774008484 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1095774008485 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1095774008486 active site 1095774008487 catalytic site [active] 1095774008488 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1095774008489 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1095774008490 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1095774008491 active site 1095774008492 catalytic site [active] 1095774008493 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1095774008494 classical (c) SDRs; Region: SDR_c; cd05233 1095774008495 NAD(P) binding site [chemical binding]; other site 1095774008496 active site 1095774008497 Sensors of blue-light using FAD; Region: BLUF; pfam04940 1095774008498 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1095774008499 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 1095774008500 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1095774008501 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1095774008502 transcriptional regulator SlyA; Provisional; Region: PRK03573 1095774008503 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1095774008504 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1095774008505 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1095774008506 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1095774008507 HlyD family secretion protein; Region: HlyD_3; pfam13437 1095774008508 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1095774008509 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1095774008510 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1095774008511 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1095774008512 E-class dimer interface [polypeptide binding]; other site 1095774008513 P-class dimer interface [polypeptide binding]; other site 1095774008514 active site 1095774008515 Cu2+ binding site [ion binding]; other site 1095774008516 Zn2+ binding site [ion binding]; other site 1095774008517 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1095774008518 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1095774008519 active site 1095774008520 catalytic tetrad [active] 1095774008521 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1095774008522 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1095774008523 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1095774008524 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1095774008525 FMN binding site [chemical binding]; other site 1095774008526 active site 1095774008527 substrate binding site [chemical binding]; other site 1095774008528 catalytic residue [active] 1095774008529 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1095774008530 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1095774008531 dimer interface [polypeptide binding]; other site 1095774008532 active site 1095774008533 metal binding site [ion binding]; metal-binding site 1095774008534 glutathione binding site [chemical binding]; other site 1095774008535 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1095774008536 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1095774008537 dimer interface [polypeptide binding]; other site 1095774008538 catalytic site [active] 1095774008539 putative active site [active] 1095774008540 putative substrate binding site [chemical binding]; other site 1095774008541 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1095774008542 putative GSH binding site [chemical binding]; other site 1095774008543 catalytic residues [active] 1095774008544 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1095774008545 NlpC/P60 family; Region: NLPC_P60; pfam00877 1095774008546 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1095774008547 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774008548 DNA binding site [nucleotide binding] 1095774008549 domain linker motif; other site 1095774008550 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1095774008551 dimerization interface [polypeptide binding]; other site 1095774008552 ligand binding site [chemical binding]; other site 1095774008553 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1095774008554 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774008555 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1095774008556 dimerization interface [polypeptide binding]; other site 1095774008557 putative transporter; Provisional; Region: PRK11043 1095774008558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774008559 putative substrate translocation pore; other site 1095774008560 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1095774008561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774008562 S-adenosylmethionine binding site [chemical binding]; other site 1095774008563 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1095774008564 Lumazine binding domain; Region: Lum_binding; pfam00677 1095774008565 Lumazine binding domain; Region: Lum_binding; pfam00677 1095774008566 multidrug efflux protein; Reviewed; Region: PRK01766 1095774008567 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1095774008568 cation binding site [ion binding]; other site 1095774008569 pyruvate kinase; Provisional; Region: PRK09206 1095774008570 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1095774008571 domain interfaces; other site 1095774008572 active site 1095774008573 murein lipoprotein; Provisional; Region: PRK15396 1095774008574 L,D-transpeptidase; Provisional; Region: PRK10190 1095774008575 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1095774008576 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1095774008577 cysteine desufuration protein SufE; Provisional; Region: PRK09296 1095774008578 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1095774008579 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1095774008580 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1095774008581 catalytic residue [active] 1095774008582 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1095774008583 FeS assembly protein SufD; Region: sufD; TIGR01981 1095774008584 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1095774008585 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1095774008586 Walker A/P-loop; other site 1095774008587 ATP binding site [chemical binding]; other site 1095774008588 Q-loop/lid; other site 1095774008589 ABC transporter signature motif; other site 1095774008590 Walker B; other site 1095774008591 D-loop; other site 1095774008592 H-loop/switch region; other site 1095774008593 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1095774008594 putative ABC transporter; Region: ycf24; CHL00085 1095774008595 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1095774008596 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1095774008597 FAD binding domain; Region: FAD_binding_4; pfam01565 1095774008598 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1095774008599 putative inner membrane protein; Provisional; Region: PRK10983 1095774008600 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1095774008601 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1095774008602 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1095774008603 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1095774008604 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1095774008605 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1095774008606 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1095774008607 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1095774008608 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1095774008609 hypothetical protein; Validated; Region: PRK00029 1095774008610 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1095774008611 NlpC/P60 family; Region: NLPC_P60; pfam00877 1095774008612 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 1095774008613 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1095774008614 Walker A/P-loop; other site 1095774008615 ATP binding site [chemical binding]; other site 1095774008616 Q-loop/lid; other site 1095774008617 ABC transporter signature motif; other site 1095774008618 Walker B; other site 1095774008619 D-loop; other site 1095774008620 H-loop/switch region; other site 1095774008621 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1095774008622 catalytic residues [active] 1095774008623 dimer interface [polypeptide binding]; other site 1095774008624 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1095774008625 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1095774008626 ABC-ATPase subunit interface; other site 1095774008627 dimer interface [polypeptide binding]; other site 1095774008628 putative PBP binding regions; other site 1095774008629 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1095774008630 IHF dimer interface [polypeptide binding]; other site 1095774008631 IHF - DNA interface [nucleotide binding]; other site 1095774008632 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1095774008633 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1095774008634 putative tRNA-binding site [nucleotide binding]; other site 1095774008635 B3/4 domain; Region: B3_4; pfam03483 1095774008636 tRNA synthetase B5 domain; Region: B5; smart00874 1095774008637 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1095774008638 dimer interface [polypeptide binding]; other site 1095774008639 motif 1; other site 1095774008640 motif 3; other site 1095774008641 motif 2; other site 1095774008642 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1095774008643 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1095774008644 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1095774008645 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1095774008646 dimer interface [polypeptide binding]; other site 1095774008647 motif 1; other site 1095774008648 active site 1095774008649 motif 2; other site 1095774008650 motif 3; other site 1095774008651 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1095774008652 23S rRNA binding site [nucleotide binding]; other site 1095774008653 L21 binding site [polypeptide binding]; other site 1095774008654 L13 binding site [polypeptide binding]; other site 1095774008655 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1095774008656 translation initiation factor IF-3; Region: infC; TIGR00168 1095774008657 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1095774008658 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1095774008659 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1095774008660 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1095774008661 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1095774008662 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1095774008663 active site 1095774008664 dimer interface [polypeptide binding]; other site 1095774008665 motif 1; other site 1095774008666 motif 2; other site 1095774008667 motif 3; other site 1095774008668 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1095774008669 anticodon binding site; other site 1095774008670 Protein of unknown function, DUF481; Region: DUF481; cl01213 1095774008671 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1095774008672 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 1095774008673 Phosphotransferase enzyme family; Region: APH; pfam01636 1095774008674 YniB-like protein; Region: YniB; pfam14002 1095774008675 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1095774008676 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1095774008677 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774008678 motif II; other site 1095774008679 inner membrane protein; Provisional; Region: PRK11648 1095774008680 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1095774008681 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1095774008682 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1095774008683 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1095774008684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774008685 putative substrate translocation pore; other site 1095774008686 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1095774008687 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1095774008688 homodimer interface [polypeptide binding]; other site 1095774008689 NAD binding pocket [chemical binding]; other site 1095774008690 ATP binding pocket [chemical binding]; other site 1095774008691 Mg binding site [ion binding]; other site 1095774008692 active-site loop [active] 1095774008693 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1095774008694 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1095774008695 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774008696 dimer interface [polypeptide binding]; other site 1095774008697 putative CheW interface [polypeptide binding]; other site 1095774008698 aromatic amino acid exporter; Provisional; Region: PRK11689 1095774008699 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1095774008700 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1095774008701 GIY-YIG motif/motif A; other site 1095774008702 active site 1095774008703 catalytic site [active] 1095774008704 putative DNA binding site [nucleotide binding]; other site 1095774008705 metal binding site [ion binding]; metal-binding site 1095774008706 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1095774008707 dimer interface [polypeptide binding]; other site 1095774008708 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1095774008709 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1095774008710 putative active site [active] 1095774008711 Zn binding site [ion binding]; other site 1095774008712 succinylarginine dihydrolase; Provisional; Region: PRK13281 1095774008713 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1095774008714 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1095774008715 NAD(P) binding site [chemical binding]; other site 1095774008716 catalytic residues [active] 1095774008717 arginine succinyltransferase; Provisional; Region: PRK10456 1095774008718 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1095774008719 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1095774008720 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1095774008721 inhibitor-cofactor binding pocket; inhibition site 1095774008722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774008723 catalytic residue [active] 1095774008724 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1095774008725 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1095774008726 eyelet of channel; other site 1095774008727 trimer interface [polypeptide binding]; other site 1095774008728 putative invasin; Provisional; Region: PRK10177 1095774008729 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1095774008730 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1095774008731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1095774008732 NAD(P) binding site [chemical binding]; other site 1095774008733 active site 1095774008734 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1095774008735 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1095774008736 TM-ABC transporter signature motif; other site 1095774008737 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1095774008738 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1095774008739 Walker A/P-loop; other site 1095774008740 ATP binding site [chemical binding]; other site 1095774008741 Q-loop/lid; other site 1095774008742 ABC transporter signature motif; other site 1095774008743 Walker B; other site 1095774008744 D-loop; other site 1095774008745 H-loop/switch region; other site 1095774008746 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1095774008747 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 1095774008748 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1095774008749 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1095774008750 short chain dehydrogenase; Provisional; Region: PRK06841 1095774008751 classical (c) SDRs; Region: SDR_c; cd05233 1095774008752 NAD(P) binding site [chemical binding]; other site 1095774008753 active site 1095774008754 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1095774008755 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1095774008756 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1095774008757 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1095774008758 active site 1095774008759 SAM binding site [chemical binding]; other site 1095774008760 homodimer interface [polypeptide binding]; other site 1095774008761 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1095774008762 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1095774008763 [4Fe-4S] binding site [ion binding]; other site 1095774008764 molybdopterin cofactor binding site; other site 1095774008765 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1095774008766 molybdopterin cofactor binding site; other site 1095774008767 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1095774008768 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1095774008769 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1095774008770 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1095774008771 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1095774008772 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1095774008773 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1095774008774 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1095774008775 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1095774008776 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1095774008777 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1095774008778 Walker A/P-loop; other site 1095774008779 ATP binding site [chemical binding]; other site 1095774008780 Q-loop/lid; other site 1095774008781 ABC transporter signature motif; other site 1095774008782 Walker B; other site 1095774008783 D-loop; other site 1095774008784 H-loop/switch region; other site 1095774008785 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1095774008786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774008787 dimer interface [polypeptide binding]; other site 1095774008788 conserved gate region; other site 1095774008789 putative PBP binding loops; other site 1095774008790 ABC-ATPase subunit interface; other site 1095774008791 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1095774008792 NMT1-like family; Region: NMT1_2; pfam13379 1095774008793 Nitrate and nitrite sensing; Region: NIT; pfam08376 1095774008794 ANTAR domain; Region: ANTAR; pfam03861 1095774008795 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1095774008796 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1095774008797 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1095774008798 ligand binding site [chemical binding]; other site 1095774008799 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 1095774008800 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1095774008801 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 1095774008802 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1095774008803 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 1095774008804 phosphopeptide binding site; other site 1095774008805 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 1095774008806 active site 1095774008807 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1095774008808 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1095774008809 active site 1095774008810 ATP binding site [chemical binding]; other site 1095774008811 substrate binding site [chemical binding]; other site 1095774008812 activation loop (A-loop); other site 1095774008813 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1095774008814 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1095774008815 putative active site pocket [active] 1095774008816 dimerization interface [polypeptide binding]; other site 1095774008817 putative catalytic residue [active] 1095774008818 cation transport regulator; Reviewed; Region: chaB; PRK09582 1095774008819 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1095774008820 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1095774008821 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1095774008822 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1095774008823 hypothetical protein; Provisional; Region: PRK10941 1095774008824 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1095774008825 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 1095774008826 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1095774008827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774008828 S-adenosylmethionine binding site [chemical binding]; other site 1095774008829 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1095774008830 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1095774008831 RF-1 domain; Region: RF-1; pfam00472 1095774008832 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1095774008833 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1095774008834 tRNA; other site 1095774008835 putative tRNA binding site [nucleotide binding]; other site 1095774008836 putative NADP binding site [chemical binding]; other site 1095774008837 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1095774008838 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 1095774008839 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1095774008840 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1095774008841 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1095774008842 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1095774008843 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1095774008844 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1095774008845 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1095774008846 active site 1095774008847 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1095774008848 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1095774008849 metal binding site [ion binding]; metal-binding site 1095774008850 active site 1095774008851 I-site; other site 1095774008852 hypothetical protein; Provisional; Region: PRK10692 1095774008853 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1095774008854 putative active site [active] 1095774008855 catalytic residue [active] 1095774008856 GTP-binding protein YchF; Reviewed; Region: PRK09601 1095774008857 YchF GTPase; Region: YchF; cd01900 1095774008858 G1 box; other site 1095774008859 GTP/Mg2+ binding site [chemical binding]; other site 1095774008860 Switch I region; other site 1095774008861 G2 box; other site 1095774008862 Switch II region; other site 1095774008863 G3 box; other site 1095774008864 G4 box; other site 1095774008865 G5 box; other site 1095774008866 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1095774008867 Transposase; Region: HTH_Tnp_1; cl17663 1095774008868 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1095774008869 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1095774008870 Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; cl08066 1095774008871 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 1095774008872 Conjugal transfer protein TraD; Region: TraD; pfam06412 1095774008873 MobA/MobL family; Region: MobA_MobL; pfam03389 1095774008874 Uncharacterized conserved protein [Function unknown]; Region: COG3603 1095774008875 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1095774008876 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 1095774008877 putative active site [active] 1095774008878 putative NTP binding site [chemical binding]; other site 1095774008879 putative nucleic acid binding site [nucleotide binding]; other site 1095774008880 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1095774008881 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1095774008882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1095774008883 non-specific DNA binding site [nucleotide binding]; other site 1095774008884 salt bridge; other site 1095774008885 sequence-specific DNA binding site [nucleotide binding]; other site 1095774008886 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1095774008887 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 1095774008888 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1095774008889 integrase; Provisional; Region: PRK09692 1095774008890 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1095774008891 active site 1095774008892 Int/Topo IB signature motif; other site 1095774008893 FOG: CBS domain [General function prediction only]; Region: COG0517 1095774008894 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1095774008895 Divalent cation transporter; Region: MgtE; pfam01769 1095774008896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774008897 Coenzyme A binding pocket [chemical binding]; other site 1095774008898 FIST N domain; Region: FIST; smart00897 1095774008899 FIST C domain; Region: FIST_C; pfam10442 1095774008900 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774008901 dimer interface [polypeptide binding]; other site 1095774008902 putative CheW interface [polypeptide binding]; other site 1095774008903 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1095774008904 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1095774008905 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1095774008906 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1095774008907 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1095774008908 Metal-binding active site; metal-binding site 1095774008909 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1095774008910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774008911 putative substrate translocation pore; other site 1095774008912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774008913 major facilitator superfamily transporter; Provisional; Region: PRK05122 1095774008914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774008915 putative substrate translocation pore; other site 1095774008916 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1095774008917 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1095774008918 Flavoprotein; Region: Flavoprotein; pfam02441 1095774008919 MarR family; Region: MarR_2; cl17246 1095774008920 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1095774008921 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1095774008922 catalytic residues [active] 1095774008923 dimer interface [polypeptide binding]; other site 1095774008924 methionine synthase; Provisional; Region: PRK01207 1095774008925 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1095774008926 substrate binding site [chemical binding]; other site 1095774008927 THF binding site; other site 1095774008928 zinc-binding site [ion binding]; other site 1095774008929 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 1095774008930 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1095774008931 active site 1095774008932 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1095774008933 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1095774008934 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1095774008935 catalytic motif [active] 1095774008936 Zn binding site [ion binding]; other site 1095774008937 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 1095774008938 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1095774008939 Ectoine synthase; Region: Ectoine_synth; cl17598 1095774008940 beta-D-glucuronidase; Provisional; Region: PRK10150 1095774008941 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1095774008942 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1095774008943 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1095774008944 putative outer membrane porin protein; Provisional; Region: PRK11379 1095774008945 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1095774008946 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1095774008947 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1095774008948 active site 1095774008949 P-loop; other site 1095774008950 phosphorylation site [posttranslational modification] 1095774008951 methionine cluster; other site 1095774008952 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 1095774008953 active site 1095774008954 phosphorylation site [posttranslational modification] 1095774008955 metal binding site [ion binding]; metal-binding site 1095774008956 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1095774008957 HTH domain; Region: HTH_11; pfam08279 1095774008958 PRD domain; Region: PRD; pfam00874 1095774008959 PRD domain; Region: PRD; pfam00874 1095774008960 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1095774008961 active site 1095774008962 phosphorylation site [posttranslational modification] 1095774008963 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1095774008964 dimerization interface [polypeptide binding]; other site 1095774008965 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1095774008966 NAD binding site [chemical binding]; other site 1095774008967 ligand binding site [chemical binding]; other site 1095774008968 catalytic site [active] 1095774008969 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1095774008970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1095774008971 binding surface 1095774008972 TPR motif; other site 1095774008973 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1095774008974 RNA polymerase sigma factor; Provisional; Region: PRK12511 1095774008975 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1095774008976 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1095774008977 DNA binding residues [nucleotide binding] 1095774008978 YceI-like domain; Region: YceI; pfam04264 1095774008979 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1095774008980 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1095774008981 active site 1095774008982 metal binding site [ion binding]; metal-binding site 1095774008983 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1095774008984 dimerization interface [polypeptide binding]; other site 1095774008985 putative DNA binding site [nucleotide binding]; other site 1095774008986 putative Zn2+ binding site [ion binding]; other site 1095774008987 arsenical pump membrane protein; Provisional; Region: PRK15445 1095774008988 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1095774008989 transmembrane helices; other site 1095774008990 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1095774008991 ArsC family; Region: ArsC; pfam03960 1095774008992 catalytic residues [active] 1095774008993 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 1095774008994 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1095774008995 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1095774008996 dimerization interface [polypeptide binding]; other site 1095774008997 putative DNA binding site [nucleotide binding]; other site 1095774008998 putative Zn2+ binding site [ion binding]; other site 1095774008999 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1095774009000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774009001 putative substrate translocation pore; other site 1095774009002 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1095774009003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774009004 Coenzyme A binding pocket [chemical binding]; other site 1095774009005 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774009006 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1095774009007 putative DNA binding site [nucleotide binding]; other site 1095774009008 putative Zn2+ binding site [ion binding]; other site 1095774009009 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1095774009010 dimerization interface [polypeptide binding]; other site 1095774009011 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1095774009012 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1095774009013 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774009014 Coenzyme A binding pocket [chemical binding]; other site 1095774009015 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1095774009016 active site 1095774009017 DNA binding site [nucleotide binding] 1095774009018 Int/Topo IB signature motif; other site 1095774009019 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1095774009020 HAMP domain; Region: HAMP; pfam00672 1095774009021 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774009022 dimer interface [polypeptide binding]; other site 1095774009023 putative CheW interface [polypeptide binding]; other site 1095774009024 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1095774009025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1095774009026 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1095774009027 Amidase; Region: Amidase; pfam01425 1095774009028 Dehydratase family; Region: ILVD_EDD; cl00340 1095774009029 Cupin domain; Region: Cupin_2; pfam07883 1095774009030 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1095774009031 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774009032 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1095774009033 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1095774009034 N-terminal plug; other site 1095774009035 ligand-binding site [chemical binding]; other site 1095774009036 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1095774009037 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1095774009038 inhibitor site; inhibition site 1095774009039 active site 1095774009040 dimer interface [polypeptide binding]; other site 1095774009041 catalytic residue [active] 1095774009042 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1095774009043 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1095774009044 conserved cys residue [active] 1095774009045 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1095774009046 Amidohydrolase; Region: Amidohydro_2; pfam04909 1095774009047 benzoate transport; Region: 2A0115; TIGR00895 1095774009048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774009049 putative substrate translocation pore; other site 1095774009050 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1095774009051 active site 1095774009052 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1095774009053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774009054 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1095774009055 Coenzyme A binding pocket [chemical binding]; other site 1095774009056 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 1095774009057 SEC-C motif; Region: SEC-C; pfam02810 1095774009058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774009059 Coenzyme A binding pocket [chemical binding]; other site 1095774009060 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1095774009061 dimerization interface [polypeptide binding]; other site 1095774009062 putative DNA binding site [nucleotide binding]; other site 1095774009063 putative Zn2+ binding site [ion binding]; other site 1095774009064 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1095774009065 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1095774009066 FMN binding site [chemical binding]; other site 1095774009067 active site 1095774009068 substrate binding site [chemical binding]; other site 1095774009069 catalytic residue [active] 1095774009070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1095774009071 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1095774009072 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 1095774009073 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1095774009074 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1095774009075 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774009076 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1095774009077 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1095774009078 CAT RNA binding domain; Region: CAT_RBD; smart01061 1095774009079 PRD domain; Region: PRD; pfam00874 1095774009080 PRD domain; Region: PRD; pfam00874 1095774009081 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1095774009082 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1095774009083 active site turn [active] 1095774009084 phosphorylation site [posttranslational modification] 1095774009085 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1095774009086 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1095774009087 HPr interaction site; other site 1095774009088 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1095774009089 active site 1095774009090 phosphorylation site [posttranslational modification] 1095774009091 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1095774009092 beta-galactosidase; Region: BGL; TIGR03356 1095774009093 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1095774009094 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1095774009095 The ASCH domain adopts a beta-barrel fold similar to that of the PUA domain; Region: ASCH; smart01022 1095774009096 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1095774009097 Cupin; Region: Cupin_1; smart00835 1095774009098 Cupin; Region: Cupin_1; smart00835 1095774009099 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 1095774009100 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1095774009101 NAD(P) binding site [chemical binding]; other site 1095774009102 catalytic residues [active] 1095774009103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774009104 S-adenosylmethionine binding site [chemical binding]; other site 1095774009105 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1095774009106 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1095774009107 catalytic triad [active] 1095774009108 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1095774009109 EamA-like transporter family; Region: EamA; pfam00892 1095774009110 EamA-like transporter family; Region: EamA; pfam00892 1095774009111 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1095774009112 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1095774009113 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1095774009114 putative hydrolase; Validated; Region: PRK09248 1095774009115 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1095774009116 active site 1095774009117 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1095774009118 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1095774009119 putative ligand binding site [chemical binding]; other site 1095774009120 NAD binding site [chemical binding]; other site 1095774009121 dimerization interface [polypeptide binding]; other site 1095774009122 catalytic site [active] 1095774009123 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1095774009124 Trehalase; Region: Trehalase; cl17346 1095774009125 hypothetical protein; Provisional; Region: PRK10457 1095774009126 Flagellar regulator YcgR; Region: YcgR; pfam07317 1095774009127 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1095774009128 PilZ domain; Region: PilZ; pfam07238 1095774009129 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1095774009130 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1095774009131 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1095774009132 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 1095774009133 N- and C-terminal domain interface [polypeptide binding]; other site 1095774009134 active site 1095774009135 MgATP binding site [chemical binding]; other site 1095774009136 catalytic site [active] 1095774009137 metal binding site [ion binding]; metal-binding site 1095774009138 putative homotetramer interface [polypeptide binding]; other site 1095774009139 putative homodimer interface [polypeptide binding]; other site 1095774009140 glycerol binding site [chemical binding]; other site 1095774009141 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1095774009142 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1095774009143 PYR/PP interface [polypeptide binding]; other site 1095774009144 dimer interface [polypeptide binding]; other site 1095774009145 TPP binding site [chemical binding]; other site 1095774009146 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1095774009147 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1095774009148 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1095774009149 TPP-binding site [chemical binding]; other site 1095774009150 dimer interface [polypeptide binding]; other site 1095774009151 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1095774009152 MarR family; Region: MarR_2; cl17246 1095774009153 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1095774009154 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1095774009155 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1095774009156 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1095774009157 catalytic residue [active] 1095774009158 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1095774009159 dimer interface [polypeptide binding]; other site 1095774009160 catalytic triad [active] 1095774009161 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1095774009162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774009163 Coenzyme A binding pocket [chemical binding]; other site 1095774009164 CsbD-like; Region: CsbD; pfam05532 1095774009165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774009166 metabolite-proton symporter; Region: 2A0106; TIGR00883 1095774009167 putative substrate translocation pore; other site 1095774009168 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1095774009169 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774009170 DNA-binding site [nucleotide binding]; DNA binding site 1095774009171 UTRA domain; Region: UTRA; pfam07702 1095774009172 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1095774009173 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1095774009174 substrate binding site [chemical binding]; other site 1095774009175 ATP binding site [chemical binding]; other site 1095774009176 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1095774009177 nucleoside transporter; Region: 2A0110; TIGR00889 1095774009178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774009179 putative substrate translocation pore; other site 1095774009180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1095774009181 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1095774009182 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1095774009183 HlyD family secretion protein; Region: HlyD_3; pfam13437 1095774009184 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1095774009185 Protein export membrane protein; Region: SecD_SecF; cl14618 1095774009186 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1095774009187 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1095774009188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1095774009189 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1095774009190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1095774009191 hypothetical protein; Provisional; Region: PRK06185 1095774009192 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1095774009193 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1095774009194 fimbrial chaperone protein StbB; Provisional; Region: PRK15249 1095774009195 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1095774009196 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1095774009197 fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248 1095774009198 PapC N-terminal domain; Region: PapC_N; pfam13954 1095774009199 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1095774009200 PapC C-terminal domain; Region: PapC_C; pfam13953 1095774009201 putative fimbrial usher protein StbD; Provisional; Region: PRK15247 1095774009202 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 1095774009203 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1095774009204 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1095774009205 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1095774009206 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1095774009207 putative active site [active] 1095774009208 isocitrate dehydrogenase; Validated; Region: PRK07362 1095774009209 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1095774009210 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 1095774009211 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1095774009212 active site 1095774009213 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1095774009214 nudix motif; other site 1095774009215 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1095774009216 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 1095774009217 putative lysogenization regulator; Reviewed; Region: PRK00218 1095774009218 adenylosuccinate lyase; Provisional; Region: PRK09285 1095774009219 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1095774009220 tetramer interface [polypeptide binding]; other site 1095774009221 active site 1095774009222 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1095774009223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774009224 active site 1095774009225 phosphorylation site [posttranslational modification] 1095774009226 intermolecular recognition site; other site 1095774009227 dimerization interface [polypeptide binding]; other site 1095774009228 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1095774009229 DNA binding site [nucleotide binding] 1095774009230 sensor protein PhoQ; Provisional; Region: PRK10815 1095774009231 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1095774009232 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1095774009233 dimer interface [polypeptide binding]; other site 1095774009234 phosphorylation site [posttranslational modification] 1095774009235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774009236 ATP binding site [chemical binding]; other site 1095774009237 Mg2+ binding site [ion binding]; other site 1095774009238 G-X-G motif; other site 1095774009239 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1095774009240 Cupin-like domain; Region: Cupin_8; pfam13621 1095774009241 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1095774009242 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1095774009243 metal binding site [ion binding]; metal-binding site 1095774009244 dimer interface [polypeptide binding]; other site 1095774009245 NAD-dependent deacetylase; Provisional; Region: PRK00481 1095774009246 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1095774009247 NAD+ binding site [chemical binding]; other site 1095774009248 substrate binding site [chemical binding]; other site 1095774009249 Zn binding site [ion binding]; other site 1095774009250 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1095774009251 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1095774009252 FtsX-like permease family; Region: FtsX; pfam02687 1095774009253 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1095774009254 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1095774009255 Walker A/P-loop; other site 1095774009256 ATP binding site [chemical binding]; other site 1095774009257 Q-loop/lid; other site 1095774009258 ABC transporter signature motif; other site 1095774009259 Walker B; other site 1095774009260 D-loop; other site 1095774009261 H-loop/switch region; other site 1095774009262 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1095774009263 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1095774009264 FtsX-like permease family; Region: FtsX; pfam02687 1095774009265 transcription-repair coupling factor; Provisional; Region: PRK10689 1095774009266 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1095774009267 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1095774009268 ATP binding site [chemical binding]; other site 1095774009269 putative Mg++ binding site [ion binding]; other site 1095774009270 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1095774009271 nucleotide binding region [chemical binding]; other site 1095774009272 ATP-binding site [chemical binding]; other site 1095774009273 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1095774009274 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1095774009275 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1095774009276 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1095774009277 MarR family; Region: MarR_2; pfam12802 1095774009278 hypothetical protein; Provisional; Region: PRK11280 1095774009279 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1095774009280 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1095774009281 hypothetical protein; Provisional; Region: PRK04940 1095774009282 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1095774009283 beta-hexosaminidase; Provisional; Region: PRK05337 1095774009284 thiamine kinase; Region: ycfN_thiK; TIGR02721 1095774009285 active site 1095774009286 substrate binding site [chemical binding]; other site 1095774009287 ATP binding site [chemical binding]; other site 1095774009288 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1095774009289 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1095774009290 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 1095774009291 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1095774009292 putative dimer interface [polypeptide binding]; other site 1095774009293 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1095774009294 nucleotide binding site/active site [active] 1095774009295 HIT family signature motif; other site 1095774009296 catalytic residue [active] 1095774009297 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1095774009298 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1095774009299 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774009300 dimer interface [polypeptide binding]; other site 1095774009301 putative CheW interface [polypeptide binding]; other site 1095774009302 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1095774009303 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1095774009304 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1095774009305 active site turn [active] 1095774009306 phosphorylation site [posttranslational modification] 1095774009307 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1095774009308 active site 1095774009309 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1095774009310 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1095774009311 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1095774009312 thymidylate kinase; Validated; Region: tmk; PRK00698 1095774009313 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1095774009314 TMP-binding site; other site 1095774009315 ATP-binding site [chemical binding]; other site 1095774009316 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1095774009317 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1095774009318 dimerization interface [polypeptide binding]; other site 1095774009319 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1095774009320 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1095774009321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774009322 catalytic residue [active] 1095774009323 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1095774009324 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1095774009325 dimer interface [polypeptide binding]; other site 1095774009326 active site 1095774009327 acyl carrier protein; Provisional; Region: acpP; PRK00982 1095774009328 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1095774009329 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1095774009330 NAD(P) binding site [chemical binding]; other site 1095774009331 homotetramer interface [polypeptide binding]; other site 1095774009332 homodimer interface [polypeptide binding]; other site 1095774009333 active site 1095774009334 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1095774009335 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1095774009336 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1095774009337 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1095774009338 dimer interface [polypeptide binding]; other site 1095774009339 active site 1095774009340 CoA binding pocket [chemical binding]; other site 1095774009341 putative phosphate acyltransferase; Provisional; Region: PRK05331 1095774009342 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1095774009343 hypothetical protein; Provisional; Region: PRK11193 1095774009344 Maf-like protein; Region: Maf; pfam02545 1095774009345 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1095774009346 active site 1095774009347 dimer interface [polypeptide binding]; other site 1095774009348 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1095774009349 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1095774009350 RNA binding surface [nucleotide binding]; other site 1095774009351 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1095774009352 active site 1095774009353 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1095774009354 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1095774009355 homodimer interface [polypeptide binding]; other site 1095774009356 oligonucleotide binding site [chemical binding]; other site 1095774009357 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1095774009358 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 1095774009359 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1095774009360 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1095774009361 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1095774009362 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1095774009363 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1095774009364 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1095774009365 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1095774009366 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1095774009367 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1095774009368 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1095774009369 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1095774009370 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1095774009371 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1095774009372 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1095774009373 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1095774009374 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1095774009375 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1095774009376 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1095774009377 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1095774009378 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1095774009379 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1095774009380 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1095774009381 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1095774009382 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1095774009383 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1095774009384 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1095774009385 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1095774009386 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1095774009387 SAF-like; Region: SAF_2; pfam13144 1095774009388 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1095774009389 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1095774009390 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 1095774009391 FlgN protein; Region: FlgN; cl09176 1095774009392 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1095774009393 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1095774009394 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774009395 dimer interface [polypeptide binding]; other site 1095774009396 putative CheW interface [polypeptide binding]; other site 1095774009397 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1095774009398 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1095774009399 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1095774009400 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1095774009401 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1095774009402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1095774009403 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1095774009404 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1095774009405 lipoprotein; Provisional; Region: PRK10598 1095774009406 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1095774009407 active site 1095774009408 substrate binding pocket [chemical binding]; other site 1095774009409 dimer interface [polypeptide binding]; other site 1095774009410 DNA damage-inducible protein I; Provisional; Region: PRK10597 1095774009411 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1095774009412 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1095774009413 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1095774009414 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1095774009415 hypothetical protein; Provisional; Region: PRK03757 1095774009416 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1095774009417 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1095774009418 active site residue [active] 1095774009419 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1095774009420 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1095774009421 putative acyl-acceptor binding pocket; other site 1095774009422 TetR family transcriptional regulator; Provisional; Region: PRK14996 1095774009423 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1095774009424 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1095774009425 hypothetical protein; Provisional; Region: PRK09272 1095774009426 secY/secA suppressor protein; Provisional; Region: PRK11467 1095774009427 lipoprotein; Provisional; Region: PRK10175 1095774009428 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1095774009429 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1095774009430 Ligand binding site; other site 1095774009431 DXD motif; other site 1095774009432 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1095774009433 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 1095774009434 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1095774009435 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1095774009436 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1095774009437 PLD-like domain; Region: PLDc_2; pfam13091 1095774009438 putative active site [active] 1095774009439 catalytic site [active] 1095774009440 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1095774009441 PLD-like domain; Region: PLDc_2; pfam13091 1095774009442 putative active site [active] 1095774009443 catalytic site [active] 1095774009444 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1095774009445 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1095774009446 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1095774009447 HlyD family secretion protein; Region: HlyD_3; pfam13437 1095774009448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774009449 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1095774009450 putative substrate translocation pore; other site 1095774009451 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1095774009452 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1095774009453 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1095774009454 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1095774009455 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774009456 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 1095774009457 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1095774009458 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1095774009459 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1095774009460 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1095774009461 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1095774009462 YrhK-like protein; Region: YrhK; pfam14145 1095774009463 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1095774009464 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1095774009465 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1095774009466 GIY-YIG motif/motif A; other site 1095774009467 active site 1095774009468 catalytic site [active] 1095774009469 putative DNA binding site [nucleotide binding]; other site 1095774009470 metal binding site [ion binding]; metal-binding site 1095774009471 UvrB/uvrC motif; Region: UVR; pfam02151 1095774009472 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1095774009473 response regulator; Provisional; Region: PRK09483 1095774009474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774009475 active site 1095774009476 phosphorylation site [posttranslational modification] 1095774009477 intermolecular recognition site; other site 1095774009478 dimerization interface [polypeptide binding]; other site 1095774009479 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1095774009480 DNA binding residues [nucleotide binding] 1095774009481 dimerization interface [polypeptide binding]; other site 1095774009482 hypothetical protein; Provisional; Region: PRK10613 1095774009483 Autoinducer synthetase; Region: Autoind_synth; cl17404 1095774009484 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1095774009485 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1095774009486 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1095774009487 DNA binding residues [nucleotide binding] 1095774009488 dimerization interface [polypeptide binding]; other site 1095774009489 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1095774009490 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1095774009491 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1095774009492 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1095774009493 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1095774009494 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1095774009495 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1095774009496 EamA-like transporter family; Region: EamA; pfam00892 1095774009497 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1095774009498 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1095774009499 hypothetical protein; Provisional; Region: PRK10174 1095774009500 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1095774009501 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1095774009502 NAD(P) binding site [chemical binding]; other site 1095774009503 catalytic residues [active] 1095774009504 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1095774009505 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1095774009506 catalytic core [active] 1095774009507 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1095774009508 YccA-like proteins; Region: YccA_like; cd10433 1095774009509 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1095774009510 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1095774009511 DsrC like protein; Region: DsrC; pfam04358 1095774009512 acylphosphatase; Provisional; Region: PRK14426 1095774009513 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 1095774009514 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1095774009515 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1095774009516 putative RNA binding site [nucleotide binding]; other site 1095774009517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774009518 S-adenosylmethionine binding site [chemical binding]; other site 1095774009519 heat shock protein HspQ; Provisional; Region: PRK14129 1095774009520 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1095774009521 hypothetical protein; Provisional; Region: PRK03641 1095774009522 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 1095774009523 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1095774009524 active site 1095774009525 dimer interfaces [polypeptide binding]; other site 1095774009526 catalytic residues [active] 1095774009527 DNA helicase IV; Provisional; Region: helD; PRK11054 1095774009528 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1095774009529 Part of AAA domain; Region: AAA_19; pfam13245 1095774009530 Family description; Region: UvrD_C_2; pfam13538 1095774009531 Predicted membrane protein [Function unknown]; Region: COG3304 1095774009532 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1095774009533 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1095774009534 TIGR01666 family membrane protein; Region: YCCS 1095774009535 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1095774009536 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1095774009537 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1095774009538 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1095774009539 SOS cell division inhibitor; Provisional; Region: PRK10595 1095774009540 outer membrane protein A; Reviewed; Region: PRK10808 1095774009541 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1095774009542 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1095774009543 ligand binding site [chemical binding]; other site 1095774009544 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1095774009545 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1095774009546 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1095774009547 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1095774009548 active site 1 [active] 1095774009549 dimer interface [polypeptide binding]; other site 1095774009550 active site 2 [active] 1095774009551 Ribosome modulation factor; Region: RMF; pfam04957 1095774009552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1095774009553 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1095774009554 paraquat-inducible protein B; Provisional; Region: PRK10807 1095774009555 mce related protein; Region: MCE; pfam02470 1095774009556 mce related protein; Region: MCE; pfam02470 1095774009557 mce related protein; Region: MCE; pfam02470 1095774009558 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 1095774009559 Paraquat-inducible protein A; Region: PqiA; pfam04403 1095774009560 Paraquat-inducible protein A; Region: PqiA; pfam04403 1095774009561 ABC transporter ATPase component; Reviewed; Region: PRK11147 1095774009562 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1095774009563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774009564 Walker A/P-loop; other site 1095774009565 ATP binding site [chemical binding]; other site 1095774009566 Q-loop/lid; other site 1095774009567 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1095774009568 ABC transporter signature motif; other site 1095774009569 Walker B; other site 1095774009570 D-loop; other site 1095774009571 ABC transporter; Region: ABC_tran_2; pfam12848 1095774009572 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1095774009573 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1095774009574 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1095774009575 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1095774009576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774009577 S-adenosylmethionine binding site [chemical binding]; other site 1095774009578 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1095774009579 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1095774009580 MOSC domain; Region: MOSC; pfam03473 1095774009581 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1095774009582 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1095774009583 catalytic loop [active] 1095774009584 iron binding site [ion binding]; other site 1095774009585 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1095774009586 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1095774009587 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1095774009588 quinone interaction residues [chemical binding]; other site 1095774009589 active site 1095774009590 catalytic residues [active] 1095774009591 FMN binding site [chemical binding]; other site 1095774009592 substrate binding site [chemical binding]; other site 1095774009593 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1095774009594 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1095774009595 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1095774009596 active site 1095774009597 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 1095774009598 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1095774009599 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1095774009600 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774009601 substrate binding pocket [chemical binding]; other site 1095774009602 membrane-bound complex binding site; other site 1095774009603 hinge residues; other site 1095774009604 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1095774009605 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1095774009606 active site 1095774009607 dimer interface [polypeptide binding]; other site 1095774009608 non-prolyl cis peptide bond; other site 1095774009609 insertion regions; other site 1095774009610 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1095774009611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774009612 dimer interface [polypeptide binding]; other site 1095774009613 conserved gate region; other site 1095774009614 putative PBP binding loops; other site 1095774009615 ABC-ATPase subunit interface; other site 1095774009616 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1095774009617 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1095774009618 Walker A/P-loop; other site 1095774009619 ATP binding site [chemical binding]; other site 1095774009620 Q-loop/lid; other site 1095774009621 ABC transporter signature motif; other site 1095774009622 Walker B; other site 1095774009623 D-loop; other site 1095774009624 H-loop/switch region; other site 1095774009625 aminopeptidase N; Provisional; Region: pepN; PRK14015 1095774009626 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1095774009627 active site 1095774009628 Zn binding site [ion binding]; other site 1095774009629 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1095774009630 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1095774009631 active site 1095774009632 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1095774009633 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1095774009634 putative dimer interface [polypeptide binding]; other site 1095774009635 putative anticodon binding site; other site 1095774009636 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1095774009637 homodimer interface [polypeptide binding]; other site 1095774009638 motif 1; other site 1095774009639 motif 2; other site 1095774009640 active site 1095774009641 motif 3; other site 1095774009642 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1095774009643 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1095774009644 trimer interface [polypeptide binding]; other site 1095774009645 eyelet of channel; other site 1095774009646 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1095774009647 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1095774009648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774009649 homodimer interface [polypeptide binding]; other site 1095774009650 catalytic residue [active] 1095774009651 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1095774009652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1095774009653 Peptidase M15; Region: Peptidase_M15_3; cl01194 1095774009654 murein L,D-transpeptidase; Provisional; Region: PRK10594 1095774009655 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1095774009656 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1095774009657 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1095774009658 cell division protein MukB; Provisional; Region: mukB; PRK04863 1095774009659 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1095774009660 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1095774009661 condesin subunit E; Provisional; Region: PRK05256 1095774009662 condesin subunit F; Provisional; Region: PRK05260 1095774009663 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1095774009664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774009665 S-adenosylmethionine binding site [chemical binding]; other site 1095774009666 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1095774009667 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1095774009668 putative active site [active] 1095774009669 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1095774009670 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1095774009671 Ligand binding site; other site 1095774009672 oligomer interface; other site 1095774009673 Trm112p-like protein; Region: Trm112p; cl01066 1095774009674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1095774009675 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1095774009676 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1095774009677 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1095774009678 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1095774009679 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1095774009680 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1095774009681 Walker A/P-loop; other site 1095774009682 ATP binding site [chemical binding]; other site 1095774009683 Q-loop/lid; other site 1095774009684 ABC transporter signature motif; other site 1095774009685 Walker B; other site 1095774009686 D-loop; other site 1095774009687 H-loop/switch region; other site 1095774009688 ComEC family competence protein; Provisional; Region: PRK11539 1095774009689 Competence protein; Region: Competence; pfam03772 1095774009690 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1095774009691 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1095774009692 IHF dimer interface [polypeptide binding]; other site 1095774009693 IHF - DNA interface [nucleotide binding]; other site 1095774009694 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1095774009695 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1095774009696 RNA binding site [nucleotide binding]; other site 1095774009697 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1095774009698 RNA binding site [nucleotide binding]; other site 1095774009699 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1095774009700 RNA binding site [nucleotide binding]; other site 1095774009701 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1095774009702 RNA binding site [nucleotide binding]; other site 1095774009703 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1095774009704 RNA binding site [nucleotide binding]; other site 1095774009705 cytidylate kinase; Provisional; Region: cmk; PRK00023 1095774009706 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1095774009707 CMP-binding site; other site 1095774009708 The sites determining sugar specificity; other site 1095774009709 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1095774009710 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1095774009711 hinge; other site 1095774009712 active site 1095774009713 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1095774009714 homodimer interface [polypeptide binding]; other site 1095774009715 substrate-cofactor binding pocket; other site 1095774009716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774009717 catalytic residue [active] 1095774009718 uncharacterized domain; Region: TIGR00702 1095774009719 YcaO-like family; Region: YcaO; pfam02624 1095774009720 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1095774009721 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1095774009722 Pyruvate formate lyase 1; Region: PFL1; cd01678 1095774009723 coenzyme A binding site [chemical binding]; other site 1095774009724 active site 1095774009725 catalytic residues [active] 1095774009726 glycine loop; other site 1095774009727 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1095774009728 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1095774009729 FeS/SAM binding site; other site 1095774009730 putative MFS family transporter protein; Provisional; Region: PRK03633 1095774009731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774009732 putative substrate translocation pore; other site 1095774009733 seryl-tRNA synthetase; Provisional; Region: PRK05431 1095774009734 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1095774009735 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1095774009736 dimer interface [polypeptide binding]; other site 1095774009737 active site 1095774009738 motif 1; other site 1095774009739 motif 2; other site 1095774009740 motif 3; other site 1095774009741 recombination factor protein RarA; Reviewed; Region: PRK13342 1095774009742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774009743 Walker A motif; other site 1095774009744 ATP binding site [chemical binding]; other site 1095774009745 Walker B motif; other site 1095774009746 arginine finger; other site 1095774009747 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1095774009748 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1095774009749 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1095774009750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774009751 DNA translocase FtsK; Provisional; Region: PRK10263 1095774009752 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1095774009753 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1095774009754 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1095774009755 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1095774009756 putative DNA binding site [nucleotide binding]; other site 1095774009757 putative Zn2+ binding site [ion binding]; other site 1095774009758 AsnC family; Region: AsnC_trans_reg; pfam01037 1095774009759 thioredoxin reductase; Provisional; Region: PRK10262 1095774009760 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1095774009761 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1095774009762 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1095774009763 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1095774009764 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1095774009765 Walker A/P-loop; other site 1095774009766 ATP binding site [chemical binding]; other site 1095774009767 Q-loop/lid; other site 1095774009768 ABC transporter signature motif; other site 1095774009769 Walker B; other site 1095774009770 D-loop; other site 1095774009771 H-loop/switch region; other site 1095774009772 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1095774009773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774009774 Walker A/P-loop; other site 1095774009775 ATP binding site [chemical binding]; other site 1095774009776 Q-loop/lid; other site 1095774009777 ABC transporter signature motif; other site 1095774009778 Walker B; other site 1095774009779 D-loop; other site 1095774009780 H-loop/switch region; other site 1095774009781 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1095774009782 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1095774009783 rRNA binding site [nucleotide binding]; other site 1095774009784 predicted 30S ribosome binding site; other site 1095774009785 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1095774009786 Clp amino terminal domain; Region: Clp_N; pfam02861 1095774009787 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774009788 Walker A motif; other site 1095774009789 ATP binding site [chemical binding]; other site 1095774009790 Walker B motif; other site 1095774009791 arginine finger; other site 1095774009792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774009793 Walker A motif; other site 1095774009794 ATP binding site [chemical binding]; other site 1095774009795 Walker B motif; other site 1095774009796 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1095774009797 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1095774009798 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1095774009799 DNA-binding site [nucleotide binding]; DNA binding site 1095774009800 RNA-binding motif; other site 1095774009801 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1095774009802 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1095774009803 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1095774009804 putative active site [active] 1095774009805 putative metal-binding site [ion binding]; other site 1095774009806 Predicted membrane protein [Function unknown]; Region: COG2431 1095774009807 pyruvate dehydrogenase; Provisional; Region: PRK09124 1095774009808 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1095774009809 PYR/PP interface [polypeptide binding]; other site 1095774009810 dimer interface [polypeptide binding]; other site 1095774009811 tetramer interface [polypeptide binding]; other site 1095774009812 TPP binding site [chemical binding]; other site 1095774009813 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1095774009814 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1095774009815 TPP-binding site [chemical binding]; other site 1095774009816 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1095774009817 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1095774009818 tetramer interface [polypeptide binding]; other site 1095774009819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774009820 catalytic residue [active] 1095774009821 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1095774009822 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1095774009823 amidase catalytic site [active] 1095774009824 Zn binding residues [ion binding]; other site 1095774009825 substrate binding site [chemical binding]; other site 1095774009826 hypothetical protein; Provisional; Region: PRK02877 1095774009827 putative lipoprotein; Provisional; Region: PRK10533 1095774009828 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1095774009829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774009830 Walker A/P-loop; other site 1095774009831 ATP binding site [chemical binding]; other site 1095774009832 Q-loop/lid; other site 1095774009833 ABC transporter signature motif; other site 1095774009834 Walker B; other site 1095774009835 D-loop; other site 1095774009836 H-loop/switch region; other site 1095774009837 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1095774009838 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774009839 substrate binding pocket [chemical binding]; other site 1095774009840 membrane-bound complex binding site; other site 1095774009841 hinge residues; other site 1095774009842 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1095774009843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774009844 dimer interface [polypeptide binding]; other site 1095774009845 conserved gate region; other site 1095774009846 putative PBP binding loops; other site 1095774009847 ABC-ATPase subunit interface; other site 1095774009848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774009849 dimer interface [polypeptide binding]; other site 1095774009850 conserved gate region; other site 1095774009851 putative PBP binding loops; other site 1095774009852 ABC-ATPase subunit interface; other site 1095774009853 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1095774009854 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774009855 substrate binding pocket [chemical binding]; other site 1095774009856 membrane-bound complex binding site; other site 1095774009857 hinge residues; other site 1095774009858 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 1095774009859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774009860 S-adenosylmethionine binding site [chemical binding]; other site 1095774009861 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1095774009862 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1095774009863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774009864 dimer interface [polypeptide binding]; other site 1095774009865 conserved gate region; other site 1095774009866 putative PBP binding loops; other site 1095774009867 ABC-ATPase subunit interface; other site 1095774009868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774009869 dimer interface [polypeptide binding]; other site 1095774009870 conserved gate region; other site 1095774009871 putative PBP binding loops; other site 1095774009872 ABC-ATPase subunit interface; other site 1095774009873 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1095774009874 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774009875 Walker A/P-loop; other site 1095774009876 ATP binding site [chemical binding]; other site 1095774009877 Q-loop/lid; other site 1095774009878 ABC transporter signature motif; other site 1095774009879 Walker B; other site 1095774009880 D-loop; other site 1095774009881 H-loop/switch region; other site 1095774009882 TOBE domain; Region: TOBE_2; pfam08402 1095774009883 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1095774009884 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1095774009885 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1095774009886 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1095774009887 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1095774009888 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1095774009889 dimer interface [polypeptide binding]; other site 1095774009890 FMN binding site [chemical binding]; other site 1095774009891 NADPH bind site [chemical binding]; other site 1095774009892 Protein of unknown function (DUF1418); Region: DUF1418; cl11648 1095774009893 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1095774009894 GSH binding site [chemical binding]; other site 1095774009895 catalytic residues [active] 1095774009896 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1095774009897 putative transporter; Provisional; Region: PRK04972 1095774009898 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1095774009899 TrkA-C domain; Region: TrkA_C; pfam02080 1095774009900 TrkA-C domain; Region: TrkA_C; pfam02080 1095774009901 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1095774009902 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1095774009903 active site 1095774009904 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1095774009905 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 1095774009906 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1095774009907 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1095774009908 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1095774009909 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1095774009910 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1095774009911 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1095774009912 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1095774009913 active site clefts [active] 1095774009914 zinc binding site [ion binding]; other site 1095774009915 dimer interface [polypeptide binding]; other site 1095774009916 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1095774009917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774009918 S-adenosylmethionine binding site [chemical binding]; other site 1095774009919 YfjP GTPase; Region: YfjP; cd11383 1095774009920 G1 box; other site 1095774009921 GTP/Mg2+ binding site [chemical binding]; other site 1095774009922 Switch I region; other site 1095774009923 G2 box; other site 1095774009924 Switch II region; other site 1095774009925 G3 box; other site 1095774009926 G4 box; other site 1095774009927 G5 box; other site 1095774009928 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 1095774009929 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1095774009930 active site 1095774009931 NUMOD4 motif; Region: NUMOD4; pfam07463 1095774009932 HNH endonuclease; Region: HNH_3; pfam13392 1095774009933 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1095774009934 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1095774009935 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1095774009936 FeS/SAM binding site; other site 1095774009937 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 1095774009938 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1095774009939 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1095774009940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774009941 dimer interface [polypeptide binding]; other site 1095774009942 conserved gate region; other site 1095774009943 putative PBP binding loops; other site 1095774009944 ABC-ATPase subunit interface; other site 1095774009945 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1095774009946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774009947 dimer interface [polypeptide binding]; other site 1095774009948 conserved gate region; other site 1095774009949 putative PBP binding loops; other site 1095774009950 ABC-ATPase subunit interface; other site 1095774009951 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1095774009952 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1095774009953 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1095774009954 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1095774009955 Walker A/P-loop; other site 1095774009956 ATP binding site [chemical binding]; other site 1095774009957 Q-loop/lid; other site 1095774009958 ABC transporter signature motif; other site 1095774009959 Walker B; other site 1095774009960 D-loop; other site 1095774009961 H-loop/switch region; other site 1095774009962 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1095774009963 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1095774009964 Walker A/P-loop; other site 1095774009965 ATP binding site [chemical binding]; other site 1095774009966 Q-loop/lid; other site 1095774009967 ABC transporter signature motif; other site 1095774009968 Walker B; other site 1095774009969 D-loop; other site 1095774009970 H-loop/switch region; other site 1095774009971 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1095774009972 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1095774009973 catalytic nucleophile [active] 1095774009974 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1095774009975 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1095774009976 dimer interface [polypeptide binding]; other site 1095774009977 putative functional site; other site 1095774009978 putative MPT binding site; other site 1095774009979 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1095774009980 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1095774009981 ATP binding site [chemical binding]; other site 1095774009982 substrate interface [chemical binding]; other site 1095774009983 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1095774009984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774009985 Walker A/P-loop; other site 1095774009986 ATP binding site [chemical binding]; other site 1095774009987 Q-loop/lid; other site 1095774009988 ABC transporter signature motif; other site 1095774009989 Walker B; other site 1095774009990 D-loop; other site 1095774009991 H-loop/switch region; other site 1095774009992 ABC transporter; Region: ABC_tran_2; pfam12848 1095774009993 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1095774009994 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1095774009995 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1095774009996 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1095774009997 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1095774009998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774009999 putative substrate translocation pore; other site 1095774010000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774010001 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1095774010002 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1095774010003 HlyD family secretion protein; Region: HlyD_3; pfam13437 1095774010004 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1095774010005 transmembrane helices; other site 1095774010006 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1095774010007 manganese transport regulator MntR; Provisional; Region: PRK11050 1095774010008 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1095774010009 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1095774010010 outer membrane protein X; Provisional; Region: ompX; PRK09408 1095774010011 threonine and homoserine efflux system; Provisional; Region: PRK10532 1095774010012 EamA-like transporter family; Region: EamA; pfam00892 1095774010013 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1095774010014 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1095774010015 dimerization interface [polypeptide binding]; other site 1095774010016 DPS ferroxidase diiron center [ion binding]; other site 1095774010017 ion pore; other site 1095774010018 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1095774010019 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774010020 substrate binding pocket [chemical binding]; other site 1095774010021 membrane-bound complex binding site; other site 1095774010022 hinge residues; other site 1095774010023 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1095774010024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774010025 dimer interface [polypeptide binding]; other site 1095774010026 conserved gate region; other site 1095774010027 putative PBP binding loops; other site 1095774010028 ABC-ATPase subunit interface; other site 1095774010029 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1095774010030 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1095774010031 Walker A/P-loop; other site 1095774010032 ATP binding site [chemical binding]; other site 1095774010033 Q-loop/lid; other site 1095774010034 ABC transporter signature motif; other site 1095774010035 Walker B; other site 1095774010036 D-loop; other site 1095774010037 H-loop/switch region; other site 1095774010038 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1095774010039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774010040 S-adenosylmethionine binding site [chemical binding]; other site 1095774010041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1095774010042 NAD(P) binding site [chemical binding]; other site 1095774010043 active site 1095774010044 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1095774010045 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1095774010046 active sites [active] 1095774010047 tetramer interface [polypeptide binding]; other site 1095774010048 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 1095774010049 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1095774010050 Walker A/P-loop; other site 1095774010051 ATP binding site [chemical binding]; other site 1095774010052 Q-loop/lid; other site 1095774010053 ABC transporter signature motif; other site 1095774010054 Walker B; other site 1095774010055 D-loop; other site 1095774010056 H-loop/switch region; other site 1095774010057 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1095774010058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774010059 dimer interface [polypeptide binding]; other site 1095774010060 conserved gate region; other site 1095774010061 putative PBP binding loops; other site 1095774010062 ABC-ATPase subunit interface; other site 1095774010063 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1095774010064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774010065 dimer interface [polypeptide binding]; other site 1095774010066 conserved gate region; other site 1095774010067 putative PBP binding loops; other site 1095774010068 ABC-ATPase subunit interface; other site 1095774010069 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1095774010070 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774010071 substrate binding pocket [chemical binding]; other site 1095774010072 membrane-bound complex binding site; other site 1095774010073 hinge residues; other site 1095774010074 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1095774010075 imidazolonepropionase; Validated; Region: PRK09356 1095774010076 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1095774010077 active site 1095774010078 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1095774010079 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1095774010080 active site 1095774010081 HutD; Region: HutD; pfam05962 1095774010082 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1095774010083 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774010084 DNA-binding site [nucleotide binding]; DNA binding site 1095774010085 UTRA domain; Region: UTRA; pfam07702 1095774010086 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1095774010087 active sites [active] 1095774010088 tetramer interface [polypeptide binding]; other site 1095774010089 urocanate hydratase; Provisional; Region: PRK05414 1095774010090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774010091 D-galactonate transporter; Region: 2A0114; TIGR00893 1095774010092 putative substrate translocation pore; other site 1095774010093 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1095774010094 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1095774010095 active site pocket [active] 1095774010096 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1095774010097 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774010098 DNA binding site [nucleotide binding] 1095774010099 domain linker motif; other site 1095774010100 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1095774010101 putative dimerization interface [polypeptide binding]; other site 1095774010102 putative ligand binding site [chemical binding]; other site 1095774010103 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1095774010104 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1095774010105 metal binding site [ion binding]; metal-binding site 1095774010106 putative dimer interface [polypeptide binding]; other site 1095774010107 glycosyl transferase family protein; Provisional; Region: PRK08136 1095774010108 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1095774010109 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1095774010110 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1095774010111 DEAD_2; Region: DEAD_2; pfam06733 1095774010112 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1095774010113 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1095774010114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774010115 Coenzyme A binding pocket [chemical binding]; other site 1095774010116 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1095774010117 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1095774010118 non-specific DNA binding site [nucleotide binding]; other site 1095774010119 salt bridge; other site 1095774010120 sequence-specific DNA binding site [nucleotide binding]; other site 1095774010121 Cupin domain; Region: Cupin_2; cl17218 1095774010122 transcriptional regulator MirA; Provisional; Region: PRK15043 1095774010123 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1095774010124 DNA binding residues [nucleotide binding] 1095774010125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774010126 putative PBP binding loops; other site 1095774010127 dimer interface [polypeptide binding]; other site 1095774010128 ABC-ATPase subunit interface; other site 1095774010129 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1095774010130 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1095774010131 Walker A/P-loop; other site 1095774010132 ATP binding site [chemical binding]; other site 1095774010133 Q-loop/lid; other site 1095774010134 ABC transporter signature motif; other site 1095774010135 Walker B; other site 1095774010136 D-loop; other site 1095774010137 H-loop/switch region; other site 1095774010138 CBS domain; Region: CBS; pfam00571 1095774010139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774010140 dimer interface [polypeptide binding]; other site 1095774010141 conserved gate region; other site 1095774010142 ABC-ATPase subunit interface; other site 1095774010143 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1095774010144 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1095774010145 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1095774010146 active site 1095774010147 metal binding site [ion binding]; metal-binding site 1095774010148 nudix motif; other site 1095774010149 HAMP domain; Region: HAMP; pfam00672 1095774010150 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1095774010151 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774010152 dimer interface [polypeptide binding]; other site 1095774010153 putative CheW interface [polypeptide binding]; other site 1095774010154 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1095774010155 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1095774010156 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1095774010157 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1095774010158 D-lactate dehydrogenase; Provisional; Region: PRK11183 1095774010159 FAD binding domain; Region: FAD_binding_4; pfam01565 1095774010160 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1095774010161 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 1095774010162 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 1095774010163 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1095774010164 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1095774010165 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1095774010166 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1095774010167 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1095774010168 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1095774010169 oxidoreductase; Provisional; Region: PRK12743 1095774010170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1095774010171 NAD(P) binding site [chemical binding]; other site 1095774010172 active site 1095774010173 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1095774010174 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1095774010175 L,D-transpeptidase; Provisional; Region: PRK10260 1095774010176 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1095774010177 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1095774010178 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 1095774010179 Cl binding site [ion binding]; other site 1095774010180 oligomer interface [polypeptide binding]; other site 1095774010181 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1095774010182 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1095774010183 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1095774010184 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1095774010185 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1095774010186 FMN binding site [chemical binding]; other site 1095774010187 active site 1095774010188 catalytic residues [active] 1095774010189 substrate binding site [chemical binding]; other site 1095774010190 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1095774010191 active site 1095774010192 NTP binding site [chemical binding]; other site 1095774010193 metal binding triad [ion binding]; metal-binding site 1095774010194 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1095774010195 Ion channel; Region: Ion_trans_2; pfam07885 1095774010196 helicase 45; Provisional; Region: PTZ00424 1095774010197 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1095774010198 ATP binding site [chemical binding]; other site 1095774010199 Mg++ binding site [ion binding]; other site 1095774010200 motif III; other site 1095774010201 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1095774010202 nucleotide binding region [chemical binding]; other site 1095774010203 ATP-binding site [chemical binding]; other site 1095774010204 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 1095774010205 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1095774010206 putative catalytic site [active] 1095774010207 putative metal binding site [ion binding]; other site 1095774010208 putative phosphate binding site [ion binding]; other site 1095774010209 cardiolipin synthase 2; Provisional; Region: PRK11263 1095774010210 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1095774010211 putative active site [active] 1095774010212 catalytic site [active] 1095774010213 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1095774010214 putative active site [active] 1095774010215 catalytic site [active] 1095774010216 Predicted integral membrane protein [Function unknown]; Region: COG0392 1095774010217 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1095774010218 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1095774010219 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1095774010220 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1095774010221 MoaE homodimer interface [polypeptide binding]; other site 1095774010222 MoaD interaction [polypeptide binding]; other site 1095774010223 active site residues [active] 1095774010224 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1095774010225 MoaE interaction surface [polypeptide binding]; other site 1095774010226 MoeB interaction surface [polypeptide binding]; other site 1095774010227 thiocarboxylated glycine; other site 1095774010228 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1095774010229 trimer interface [polypeptide binding]; other site 1095774010230 dimer interface [polypeptide binding]; other site 1095774010231 putative active site [active] 1095774010232 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1095774010233 MPT binding site; other site 1095774010234 trimer interface [polypeptide binding]; other site 1095774010235 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1095774010236 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1095774010237 FeS/SAM binding site; other site 1095774010238 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1095774010239 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1095774010240 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1095774010241 phosphate binding site [ion binding]; other site 1095774010242 putative substrate binding pocket [chemical binding]; other site 1095774010243 dimer interface [polypeptide binding]; other site 1095774010244 excinuclease ABC subunit B; Provisional; Region: PRK05298 1095774010245 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1095774010246 ATP binding site [chemical binding]; other site 1095774010247 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1095774010248 nucleotide binding region [chemical binding]; other site 1095774010249 ATP-binding site [chemical binding]; other site 1095774010250 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1095774010251 UvrB/uvrC motif; Region: UVR; pfam02151 1095774010252 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1095774010253 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1095774010254 Walker A/P-loop; other site 1095774010255 ATP binding site [chemical binding]; other site 1095774010256 Q-loop/lid; other site 1095774010257 ABC transporter signature motif; other site 1095774010258 Walker B; other site 1095774010259 D-loop; other site 1095774010260 H-loop/switch region; other site 1095774010261 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1095774010262 AAA domain; Region: AAA_26; pfam13500 1095774010263 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1095774010264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774010265 S-adenosylmethionine binding site [chemical binding]; other site 1095774010266 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1095774010267 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1095774010268 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1095774010269 catalytic residue [active] 1095774010270 biotin synthase; Provisional; Region: PRK15108 1095774010271 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1095774010272 FeS/SAM binding site; other site 1095774010273 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1095774010274 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1095774010275 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1095774010276 inhibitor-cofactor binding pocket; inhibition site 1095774010277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774010278 catalytic residue [active] 1095774010279 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1095774010280 substrate binding site [chemical binding]; other site 1095774010281 6-phosphogluconolactonase; Provisional; Region: PRK11028 1095774010282 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1095774010283 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774010284 active site 1095774010285 motif I; other site 1095774010286 motif II; other site 1095774010287 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1095774010288 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1095774010289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774010290 Walker A/P-loop; other site 1095774010291 ATP binding site [chemical binding]; other site 1095774010292 Q-loop/lid; other site 1095774010293 ABC transporter signature motif; other site 1095774010294 Walker B; other site 1095774010295 D-loop; other site 1095774010296 H-loop/switch region; other site 1095774010297 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1095774010298 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1095774010299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774010300 dimer interface [polypeptide binding]; other site 1095774010301 conserved gate region; other site 1095774010302 putative PBP binding loops; other site 1095774010303 ABC-ATPase subunit interface; other site 1095774010304 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1095774010305 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1095774010306 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1095774010307 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1095774010308 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1095774010309 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1095774010310 TOBE domain; Region: TOBE; cl01440 1095774010311 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1095774010312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774010313 Walker A/P-loop; other site 1095774010314 ATP binding site [chemical binding]; other site 1095774010315 Q-loop/lid; other site 1095774010316 ABC transporter signature motif; other site 1095774010317 Walker B; other site 1095774010318 D-loop; other site 1095774010319 H-loop/switch region; other site 1095774010320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774010321 Walker A/P-loop; other site 1095774010322 ATP binding site [chemical binding]; other site 1095774010323 Q-loop/lid; other site 1095774010324 ABC transporter signature motif; other site 1095774010325 Walker B; other site 1095774010326 D-loop; other site 1095774010327 H-loop/switch region; other site 1095774010328 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1095774010329 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1095774010330 dimer interface [polypeptide binding]; other site 1095774010331 active site 1095774010332 galactokinase; Provisional; Region: PRK05101 1095774010333 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1095774010334 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1095774010335 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1095774010336 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1095774010337 active site 1095774010338 catalytic residues [active] 1095774010339 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1095774010340 catalytic core [active] 1095774010341 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1095774010342 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1095774010343 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1095774010344 YbgS-like protein; Region: YbgS; pfam13985 1095774010345 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1095774010346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774010347 active site 1095774010348 phosphorylation site [posttranslational modification] 1095774010349 intermolecular recognition site; other site 1095774010350 dimerization interface [polypeptide binding]; other site 1095774010351 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1095774010352 DNA binding residues [nucleotide binding] 1095774010353 dimerization interface [polypeptide binding]; other site 1095774010354 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1095774010355 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774010356 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1095774010357 substrate binding pocket [chemical binding]; other site 1095774010358 membrane-bound complex binding site; other site 1095774010359 hinge residues; other site 1095774010360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1095774010361 dimer interface [polypeptide binding]; other site 1095774010362 phosphorylation site [posttranslational modification] 1095774010363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774010364 ATP binding site [chemical binding]; other site 1095774010365 Mg2+ binding site [ion binding]; other site 1095774010366 G-X-G motif; other site 1095774010367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774010368 active site 1095774010369 phosphorylation site [posttranslational modification] 1095774010370 intermolecular recognition site; other site 1095774010371 Hpt domain; Region: Hpt; pfam01627 1095774010372 putative binding surface; other site 1095774010373 active site 1095774010374 zinc transporter ZitB; Provisional; Region: PRK03557 1095774010375 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1095774010376 quinolinate synthetase; Provisional; Region: PRK09375 1095774010377 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1095774010378 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1095774010379 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1095774010380 DNA binding site [nucleotide binding] 1095774010381 active site 1095774010382 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1095774010383 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1095774010384 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774010385 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1095774010386 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1095774010387 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1095774010388 minor groove reading motif; other site 1095774010389 helix-hairpin-helix signature motif; other site 1095774010390 substrate binding pocket [chemical binding]; other site 1095774010391 active site 1095774010392 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1095774010393 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774010394 dimerization interface [polypeptide binding]; other site 1095774010395 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774010396 dimer interface [polypeptide binding]; other site 1095774010397 putative CheW interface [polypeptide binding]; other site 1095774010398 tol-pal system protein YbgF; Provisional; Region: PRK10803 1095774010399 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1095774010400 TPR motif; other site 1095774010401 binding surface 1095774010402 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1095774010403 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1095774010404 ligand binding site [chemical binding]; other site 1095774010405 translocation protein TolB; Provisional; Region: tolB; PRK03629 1095774010406 TolB amino-terminal domain; Region: TolB_N; pfam04052 1095774010407 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1095774010408 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1095774010409 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1095774010410 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1095774010411 TolA C-terminal; Region: TolA; pfam06519 1095774010412 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1095774010413 colicin uptake protein TolR; Provisional; Region: PRK11024 1095774010414 colicin uptake protein TolQ; Provisional; Region: PRK10801 1095774010415 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1095774010416 active site 1095774010417 Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; cl11451 1095774010418 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1095774010419 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1095774010420 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1095774010421 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1095774010422 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1095774010423 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1095774010424 CoA binding domain; Region: CoA_binding; pfam02629 1095774010425 CoA-ligase; Region: Ligase_CoA; pfam00549 1095774010426 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1095774010427 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1095774010428 CoA-ligase; Region: Ligase_CoA; pfam00549 1095774010429 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1095774010430 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1095774010431 E3 interaction surface; other site 1095774010432 lipoyl attachment site [posttranslational modification]; other site 1095774010433 e3 binding domain; Region: E3_binding; pfam02817 1095774010434 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1095774010435 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1095774010436 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1095774010437 TPP-binding site [chemical binding]; other site 1095774010438 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1095774010439 dimer interface [polypeptide binding]; other site 1095774010440 PYR/PP interface [polypeptide binding]; other site 1095774010441 TPP binding site [chemical binding]; other site 1095774010442 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1095774010443 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1095774010444 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1095774010445 L-aspartate oxidase; Provisional; Region: PRK06175 1095774010446 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1095774010447 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1095774010448 cardiolipin binding site; other site 1095774010449 SdhC subunit interface [polypeptide binding]; other site 1095774010450 proximal heme binding site [chemical binding]; other site 1095774010451 Iron-sulfur protein interface; other site 1095774010452 proximal quinone binding site [chemical binding]; other site 1095774010453 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1095774010454 Iron-sulfur protein interface; other site 1095774010455 proximal quinone binding site [chemical binding]; other site 1095774010456 SdhD (CybS) interface [polypeptide binding]; other site 1095774010457 proximal heme binding site [chemical binding]; other site 1095774010458 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1095774010459 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1095774010460 dimer interface [polypeptide binding]; other site 1095774010461 active site 1095774010462 citrylCoA binding site [chemical binding]; other site 1095774010463 NADH binding [chemical binding]; other site 1095774010464 cationic pore residues; other site 1095774010465 oxalacetate/citrate binding site [chemical binding]; other site 1095774010466 coenzyme A binding site [chemical binding]; other site 1095774010467 catalytic triad [active] 1095774010468 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1095774010469 endonuclease VIII; Provisional; Region: PRK10445 1095774010470 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 1095774010471 DNA binding site [nucleotide binding] 1095774010472 catalytic residue [active] 1095774010473 H2TH interface [polypeptide binding]; other site 1095774010474 putative catalytic residues [active] 1095774010475 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1095774010476 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1095774010477 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1095774010478 putative substrate binding pocket [chemical binding]; other site 1095774010479 AC domain interface; other site 1095774010480 catalytic triad [active] 1095774010481 AB domain interface; other site 1095774010482 interchain disulfide; other site 1095774010483 Predicted membrane protein [Function unknown]; Region: COG3817 1095774010484 Protein of unknown function (DUF979); Region: DUF979; pfam06166 1095774010485 Protein of unknown function (DUF969); Region: DUF969; pfam06149 1095774010486 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1095774010487 putative active site [active] 1095774010488 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1095774010489 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1095774010490 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1095774010491 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1095774010492 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1095774010493 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1095774010494 DNA photolyase; Region: DNA_photolyase; pfam00875 1095774010495 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1095774010496 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1095774010497 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 1095774010498 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1095774010499 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1095774010500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774010501 active site 1095774010502 phosphorylation site [posttranslational modification] 1095774010503 intermolecular recognition site; other site 1095774010504 dimerization interface [polypeptide binding]; other site 1095774010505 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1095774010506 DNA binding site [nucleotide binding] 1095774010507 phosphoglucomutase; Validated; Region: PRK07564 1095774010508 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1095774010509 active site 1095774010510 substrate binding site [chemical binding]; other site 1095774010511 metal binding site [ion binding]; metal-binding site 1095774010512 replication initiation regulator SeqA; Provisional; Region: PRK11187 1095774010513 acyl-CoA esterase; Provisional; Region: PRK10673 1095774010514 PGAP1-like protein; Region: PGAP1; pfam07819 1095774010515 LexA regulated protein; Provisional; Region: PRK11675 1095774010516 flavodoxin FldA; Validated; Region: PRK09267 1095774010517 ferric uptake regulator; Provisional; Region: fur; PRK09462 1095774010518 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1095774010519 metal binding site 2 [ion binding]; metal-binding site 1095774010520 putative DNA binding helix; other site 1095774010521 metal binding site 1 [ion binding]; metal-binding site 1095774010522 dimer interface [polypeptide binding]; other site 1095774010523 structural Zn2+ binding site [ion binding]; other site 1095774010524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1095774010525 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1095774010526 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1095774010527 active site 1095774010528 HIGH motif; other site 1095774010529 nucleotide binding site [chemical binding]; other site 1095774010530 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1095774010531 KMSKS motif; other site 1095774010532 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1095774010533 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1095774010534 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1095774010535 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1095774010536 active site turn [active] 1095774010537 phosphorylation site [posttranslational modification] 1095774010538 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1095774010539 HPr interaction site; other site 1095774010540 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1095774010541 active site 1095774010542 phosphorylation site [posttranslational modification] 1095774010543 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1095774010544 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1095774010545 active site 1095774010546 trimer interface [polypeptide binding]; other site 1095774010547 allosteric site; other site 1095774010548 active site lid [active] 1095774010549 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1095774010550 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1095774010551 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1095774010552 active site 1095774010553 dimer interface [polypeptide binding]; other site 1095774010554 MarR family; Region: MarR; pfam01047 1095774010555 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1095774010556 ROK family; Region: ROK; pfam00480 1095774010557 UMP phosphatase; Provisional; Region: PRK10444 1095774010558 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774010559 active site 1095774010560 motif I; other site 1095774010561 motif II; other site 1095774010562 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774010563 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1095774010564 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1095774010565 active site 1095774010566 dimer interface [polypeptide binding]; other site 1095774010567 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1095774010568 Ligand Binding Site [chemical binding]; other site 1095774010569 Molecular Tunnel; other site 1095774010570 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1095774010571 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1095774010572 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1095774010573 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1095774010574 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1095774010575 FeS/SAM binding site; other site 1095774010576 TRAM domain; Region: TRAM; pfam01938 1095774010577 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1095774010578 PhoH-like protein; Region: PhoH; pfam02562 1095774010579 metal-binding heat shock protein; Provisional; Region: PRK00016 1095774010580 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1095774010581 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1095774010582 Transporter associated domain; Region: CorC_HlyC; smart01091 1095774010583 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1095774010584 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1095774010585 putative active site [active] 1095774010586 catalytic triad [active] 1095774010587 putative dimer interface [polypeptide binding]; other site 1095774010588 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1095774010589 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774010590 substrate binding pocket [chemical binding]; other site 1095774010591 membrane-bound complex binding site; other site 1095774010592 hinge residues; other site 1095774010593 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1095774010594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774010595 dimer interface [polypeptide binding]; other site 1095774010596 conserved gate region; other site 1095774010597 putative PBP binding loops; other site 1095774010598 ABC-ATPase subunit interface; other site 1095774010599 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1095774010600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774010601 dimer interface [polypeptide binding]; other site 1095774010602 conserved gate region; other site 1095774010603 putative PBP binding loops; other site 1095774010604 ABC-ATPase subunit interface; other site 1095774010605 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1095774010606 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1095774010607 Walker A/P-loop; other site 1095774010608 ATP binding site [chemical binding]; other site 1095774010609 Q-loop/lid; other site 1095774010610 ABC transporter signature motif; other site 1095774010611 Walker B; other site 1095774010612 D-loop; other site 1095774010613 H-loop/switch region; other site 1095774010614 hypothetical protein; Provisional; Region: PRK11032 1095774010615 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1095774010616 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1095774010617 HIGH motif; other site 1095774010618 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1095774010619 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1095774010620 active site 1095774010621 KMSKS motif; other site 1095774010622 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1095774010623 tRNA binding surface [nucleotide binding]; other site 1095774010624 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1095774010625 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1095774010626 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1095774010627 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1095774010628 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1095774010629 active site 1095774010630 (T/H)XGH motif; other site 1095774010631 ribosome-associated protein; Provisional; Region: PRK11538 1095774010632 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1095774010633 penicillin-binding protein 2; Provisional; Region: PRK10795 1095774010634 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1095774010635 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1095774010636 cell wall shape-determining protein; Provisional; Region: PRK10794 1095774010637 rare lipoprotein A; Provisional; Region: PRK10672 1095774010638 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1095774010639 Sporulation related domain; Region: SPOR; pfam05036 1095774010640 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1095774010641 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1095774010642 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1095774010643 hypothetical protein; Provisional; Region: PRK04998 1095774010644 lipoate-protein ligase B; Provisional; Region: PRK14342 1095774010645 lipoyl synthase; Provisional; Region: PRK05481 1095774010646 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1095774010647 FeS/SAM binding site; other site 1095774010648 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 1095774010649 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1095774010650 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1095774010651 putative active site [active] 1095774010652 catalytic triad [active] 1095774010653 putative dimer interface [polypeptide binding]; other site 1095774010654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774010655 Coenzyme A binding pocket [chemical binding]; other site 1095774010656 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1095774010657 DNA-binding site [nucleotide binding]; DNA binding site 1095774010658 RNA-binding motif; other site 1095774010659 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1095774010660 high-affinity gluconate transporter; Provisional; Region: PRK14984 1095774010661 gluconate transporter; Region: gntP; TIGR00791 1095774010662 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1095774010663 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1095774010664 active site 1095774010665 NAD binding site [chemical binding]; other site 1095774010666 metal binding site [ion binding]; metal-binding site 1095774010667 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1095774010668 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774010669 active site 1095774010670 motif I; other site 1095774010671 motif II; other site 1095774010672 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774010673 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 1095774010674 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 1095774010675 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1095774010676 intersubunit interface [polypeptide binding]; other site 1095774010677 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1095774010678 serine transporter; Region: stp; TIGR00814 1095774010679 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1095774010680 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1095774010681 NAD binding site [chemical binding]; other site 1095774010682 catalytic Zn binding site [ion binding]; other site 1095774010683 structural Zn binding site [ion binding]; other site 1095774010684 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1095774010685 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1095774010686 active site 1095774010687 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1095774010688 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1095774010689 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1095774010690 Cupin domain; Region: Cupin_2; cl17218 1095774010691 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1095774010692 putative lipid kinase; Reviewed; Region: PRK13057 1095774010693 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1095774010694 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1095774010695 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1095774010696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774010697 S-adenosylmethionine binding site [chemical binding]; other site 1095774010698 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1095774010699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774010700 putative substrate translocation pore; other site 1095774010701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774010702 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1095774010703 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1095774010704 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1095774010705 hypothetical protein; Provisional; Region: PRK09897 1095774010706 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1095774010707 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 1095774010708 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 1095774010709 putative symporter YagG; Provisional; Region: PRK09669 1095774010710 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1095774010711 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 1095774010712 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 1095774010713 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1095774010714 substrate binding site [chemical binding]; other site 1095774010715 trimer interface [polypeptide binding]; other site 1095774010716 Mn binding site [ion binding]; other site 1095774010717 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 1095774010718 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 1095774010719 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 1095774010720 PAAR motif; Region: PAAR_motif; pfam05488 1095774010721 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1095774010722 RHS Repeat; Region: RHS_repeat; pfam05593 1095774010723 RHS Repeat; Region: RHS_repeat; cl11982 1095774010724 RHS Repeat; Region: RHS_repeat; cl11982 1095774010725 RHS protein; Region: RHS; pfam03527 1095774010726 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1095774010727 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1095774010728 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1095774010729 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 1095774010730 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1095774010731 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1095774010732 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 1095774010733 Baseplate J-like protein; Region: Baseplate_J; cl01294 1095774010734 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1095774010735 RNAse P Rpr2/Rpp21/SNM1 subunit domain; Region: Rpr2; cl00887 1095774010736 virion protein; Provisional; Region: V; PHA02564 1095774010737 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 1095774010738 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 1095774010739 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 1095774010740 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1095774010741 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 1095774010742 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 1095774010743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 1095774010744 Terminase-like family; Region: Terminase_6; pfam03237 1095774010745 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 1095774010746 Uncharacterized conserved protein (DUF2280); Region: DUF2280; pfam10045 1095774010747 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1095774010748 catalytic residues [active] 1095774010749 Predicted membrane protein [Function unknown]; Region: COG3462 1095774010750 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1095774010751 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 1095774010752 Replication protein P; Region: Phage_lambda_P; pfam06992 1095774010753 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 1095774010754 T5orf172 domain; Region: T5orf172; pfam10544 1095774010755 Bacteriophage CII protein; Region: Phage_CII; pfam05269 1095774010756 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 1095774010757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1095774010758 non-specific DNA binding site [nucleotide binding]; other site 1095774010759 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1095774010760 salt bridge; other site 1095774010761 sequence-specific DNA binding site [nucleotide binding]; other site 1095774010762 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1095774010763 Catalytic site [active] 1095774010764 RecT family; Region: RecT; pfam03837 1095774010765 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 1095774010766 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A; cl17680 1095774010767 MT-A70; Region: MT-A70; cl01947 1095774010768 Helix-turn-helix domain; Region: HTH_17; pfam12728 1095774010769 integrase; Provisional; Region: int; PHA02601 1095774010770 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 1095774010771 Int/Topo IB signature motif; other site 1095774010772 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 1095774010773 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1095774010774 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1095774010775 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1095774010776 homodimer interface [polypeptide binding]; other site 1095774010777 NADP binding site [chemical binding]; other site 1095774010778 substrate binding site [chemical binding]; other site 1095774010779 ribosome-associated protein; Provisional; Region: PRK11507 1095774010780 Predicted ATPase [General function prediction only]; Region: COG4637 1095774010781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774010782 Walker A/P-loop; other site 1095774010783 ATP binding site [chemical binding]; other site 1095774010784 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1095774010785 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1095774010786 active site 1095774010787 HIGH motif; other site 1095774010788 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1095774010789 KMSKS motif; other site 1095774010790 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1095774010791 tRNA binding surface [nucleotide binding]; other site 1095774010792 anticodon binding site; other site 1095774010793 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1095774010794 substrate binding site [chemical binding]; other site 1095774010795 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1095774010796 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1095774010797 putative active site [active] 1095774010798 putative metal binding site [ion binding]; other site 1095774010799 Predicted membrane protein [Function unknown]; Region: COG4325 1095774010800 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1095774010801 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1095774010802 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1095774010803 ATP-grasp domain; Region: ATP-grasp; pfam02222 1095774010804 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1095774010805 FtsX-like permease family; Region: FtsX; pfam02687 1095774010806 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 1095774010807 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1095774010808 Walker A/P-loop; other site 1095774010809 ATP binding site [chemical binding]; other site 1095774010810 Q-loop/lid; other site 1095774010811 ABC transporter signature motif; other site 1095774010812 Walker B; other site 1095774010813 D-loop; other site 1095774010814 H-loop/switch region; other site 1095774010815 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1095774010816 active site 1095774010817 catalytic triad [active] 1095774010818 oxyanion hole [active] 1095774010819 switch loop; other site 1095774010820 oxidoreductase; Provisional; Region: PRK08017 1095774010821 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1095774010822 NADP binding site [chemical binding]; other site 1095774010823 active site 1095774010824 steroid binding site; other site 1095774010825 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1095774010826 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1095774010827 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1095774010828 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1095774010829 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1095774010830 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1095774010831 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1095774010832 DNA binding residues [nucleotide binding] 1095774010833 dimer interface [polypeptide binding]; other site 1095774010834 copper binding site [ion binding]; other site 1095774010835 copper exporting ATPase; Provisional; Region: copA; PRK10671 1095774010836 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1095774010837 metal-binding site [ion binding] 1095774010838 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1095774010839 metal-binding site [ion binding] 1095774010840 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1095774010841 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774010842 motif II; other site 1095774010843 TraB family; Region: TraB; cl12050 1095774010844 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1095774010845 putative deacylase active site [active] 1095774010846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774010847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774010848 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1095774010849 dimerization interface [polypeptide binding]; other site 1095774010850 Predicted membrane protein [Function unknown]; Region: COG4125 1095774010851 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1095774010852 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 1095774010853 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1095774010854 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1095774010855 active site 1095774010856 metal binding site [ion binding]; metal-binding site 1095774010857 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1095774010858 putative cation:proton antiport protein; Provisional; Region: PRK10669 1095774010859 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1095774010860 TrkA-N domain; Region: TrkA_N; pfam02254 1095774010861 inosine/guanosine kinase; Provisional; Region: PRK15074 1095774010862 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1095774010863 adenylate kinase; Reviewed; Region: adk; PRK00279 1095774010864 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1095774010865 AMP-binding site [chemical binding]; other site 1095774010866 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1095774010867 heat shock protein 90; Provisional; Region: PRK05218 1095774010868 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774010869 ATP binding site [chemical binding]; other site 1095774010870 Mg2+ binding site [ion binding]; other site 1095774010871 G-X-G motif; other site 1095774010872 recombination protein RecR; Reviewed; Region: recR; PRK00076 1095774010873 RecR protein; Region: RecR; pfam02132 1095774010874 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1095774010875 putative active site [active] 1095774010876 putative metal-binding site [ion binding]; other site 1095774010877 tetramer interface [polypeptide binding]; other site 1095774010878 hypothetical protein; Validated; Region: PRK00153 1095774010879 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1095774010880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774010881 Walker A motif; other site 1095774010882 ATP binding site [chemical binding]; other site 1095774010883 Walker B motif; other site 1095774010884 arginine finger; other site 1095774010885 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1095774010886 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1095774010887 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1095774010888 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1095774010889 active site 1095774010890 hypothetical protein; Provisional; Region: PRK10527 1095774010891 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 1095774010892 hypothetical protein; Provisional; Region: PRK11038 1095774010893 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1095774010894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1095774010895 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1095774010896 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1095774010897 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1095774010898 HlyD family secretion protein; Region: HlyD_3; pfam13437 1095774010899 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1095774010900 Protein export membrane protein; Region: SecD_SecF; cl14618 1095774010901 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1095774010902 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1095774010903 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1095774010904 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1095774010905 metal binding site [ion binding]; metal-binding site 1095774010906 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1095774010907 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1095774010908 ABC-ATPase subunit interface; other site 1095774010909 dimer interface [polypeptide binding]; other site 1095774010910 putative PBP binding regions; other site 1095774010911 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1095774010912 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1095774010913 Hha toxicity attenuator; Provisional; Region: PRK10667 1095774010914 gene expression modulator; Provisional; Region: PRK10945 1095774010915 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1095774010916 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1095774010917 DNA binding site [nucleotide binding] 1095774010918 active site 1095774010919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1095774010920 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1095774010921 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1095774010922 active site 1095774010923 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1095774010924 catalytic triad [active] 1095774010925 dimer interface [polypeptide binding]; other site 1095774010926 ammonium transporter; Provisional; Region: PRK10666 1095774010927 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1095774010928 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1095774010929 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1095774010930 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1095774010931 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774010932 Walker A/P-loop; other site 1095774010933 ATP binding site [chemical binding]; other site 1095774010934 Q-loop/lid; other site 1095774010935 ABC transporter signature motif; other site 1095774010936 Walker B; other site 1095774010937 D-loop; other site 1095774010938 H-loop/switch region; other site 1095774010939 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1095774010940 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1095774010941 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774010942 Walker A/P-loop; other site 1095774010943 ATP binding site [chemical binding]; other site 1095774010944 Q-loop/lid; other site 1095774010945 ABC transporter signature motif; other site 1095774010946 Walker B; other site 1095774010947 D-loop; other site 1095774010948 H-loop/switch region; other site 1095774010949 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1095774010950 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1095774010951 putative DNA binding site [nucleotide binding]; other site 1095774010952 putative Zn2+ binding site [ion binding]; other site 1095774010953 AsnC family; Region: AsnC_trans_reg; pfam01037 1095774010954 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1095774010955 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1095774010956 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1095774010957 catalytic residue [active] 1095774010958 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1095774010959 Ligand Binding Site [chemical binding]; other site 1095774010960 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1095774010961 active site 1095774010962 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1095774010963 periplasmic folding chaperone; Provisional; Region: PRK10788 1095774010964 SurA N-terminal domain; Region: SurA_N_3; cl07813 1095774010965 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1095774010966 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1095774010967 IHF dimer interface [polypeptide binding]; other site 1095774010968 IHF - DNA interface [nucleotide binding]; other site 1095774010969 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1095774010970 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1095774010971 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1095774010972 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774010973 Walker A motif; other site 1095774010974 ATP binding site [chemical binding]; other site 1095774010975 Walker B motif; other site 1095774010976 arginine finger; other site 1095774010977 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1095774010978 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1095774010979 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1095774010980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774010981 Walker A motif; other site 1095774010982 ATP binding site [chemical binding]; other site 1095774010983 Walker B motif; other site 1095774010984 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1095774010985 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1095774010986 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1095774010987 oligomer interface [polypeptide binding]; other site 1095774010988 active site residues [active] 1095774010989 trigger factor; Provisional; Region: tig; PRK01490 1095774010990 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1095774010991 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1095774010992 transcriptional regulator BolA; Provisional; Region: PRK11628 1095774010993 hypothetical protein; Provisional; Region: PRK11627 1095774010994 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1095774010995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774010996 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1095774010997 putative substrate translocation pore; other site 1095774010998 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1095774010999 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1095774011000 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1095774011001 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1095774011002 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1095774011003 D-pathway; other site 1095774011004 Putative ubiquinol binding site [chemical binding]; other site 1095774011005 Low-spin heme (heme b) binding site [chemical binding]; other site 1095774011006 Putative water exit pathway; other site 1095774011007 Binuclear center (heme o3/CuB) [ion binding]; other site 1095774011008 K-pathway; other site 1095774011009 Putative proton exit pathway; other site 1095774011010 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1095774011011 Subunit I/III interface [polypeptide binding]; other site 1095774011012 Subunit III/IV interface [polypeptide binding]; other site 1095774011013 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1095774011014 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1095774011015 UbiA prenyltransferase family; Region: UbiA; pfam01040 1095774011016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774011017 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1095774011018 putative substrate translocation pore; other site 1095774011019 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1095774011020 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1095774011021 NAD binding site [chemical binding]; other site 1095774011022 substrate binding site [chemical binding]; other site 1095774011023 catalytic Zn binding site [ion binding]; other site 1095774011024 tetramer interface [polypeptide binding]; other site 1095774011025 structural Zn binding site [ion binding]; other site 1095774011026 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1095774011027 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1095774011028 NAD(P) binding site [chemical binding]; other site 1095774011029 catalytic residues [active] 1095774011030 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1095774011031 GAF domain; Region: GAF; pfam01590 1095774011032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774011033 Walker A motif; other site 1095774011034 ATP binding site [chemical binding]; other site 1095774011035 Walker B motif; other site 1095774011036 arginine finger; other site 1095774011037 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1095774011038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1095774011039 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1095774011040 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1095774011041 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1095774011042 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1095774011043 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1095774011044 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1095774011045 conserved cys residue [active] 1095774011046 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1095774011047 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1095774011048 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1095774011049 Ligand Binding Site [chemical binding]; other site 1095774011050 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1095774011051 active site residue [active] 1095774011052 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1095774011053 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1095774011054 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1095774011055 substrate binding pocket [chemical binding]; other site 1095774011056 chain length determination region; other site 1095774011057 substrate-Mg2+ binding site; other site 1095774011058 catalytic residues [active] 1095774011059 aspartate-rich region 1; other site 1095774011060 active site lid residues [active] 1095774011061 aspartate-rich region 2; other site 1095774011062 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1095774011063 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1095774011064 TPP-binding site; other site 1095774011065 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1095774011066 PYR/PP interface [polypeptide binding]; other site 1095774011067 dimer interface [polypeptide binding]; other site 1095774011068 TPP binding site [chemical binding]; other site 1095774011069 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1095774011070 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1095774011071 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1095774011072 active site 1095774011073 catalytic tetrad [active] 1095774011074 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1095774011075 tetramer interfaces [polypeptide binding]; other site 1095774011076 binuclear metal-binding site [ion binding]; other site 1095774011077 thiamine monophosphate kinase; Provisional; Region: PRK05731 1095774011078 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1095774011079 ATP binding site [chemical binding]; other site 1095774011080 dimerization interface [polypeptide binding]; other site 1095774011081 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1095774011082 putative RNA binding site [nucleotide binding]; other site 1095774011083 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1095774011084 homopentamer interface [polypeptide binding]; other site 1095774011085 active site 1095774011086 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1095774011087 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1095774011088 catalytic motif [active] 1095774011089 Zn binding site [ion binding]; other site 1095774011090 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1095774011091 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1095774011092 ATP cone domain; Region: ATP-cone; pfam03477 1095774011093 hypothetical protein; Provisional; Region: PRK11530 1095774011094 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1095774011095 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1095774011096 Protein export membrane protein; Region: SecD_SecF; pfam02355 1095774011097 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1095774011098 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1095774011099 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1095774011100 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1095774011101 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1095774011102 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1095774011103 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1095774011104 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1095774011105 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1095774011106 Protein of unknown function, DUF479; Region: DUF479; cl01203 1095774011107 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1095774011108 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1095774011109 active site 1095774011110 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1095774011111 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1095774011112 catalytic core [active] 1095774011113 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1095774011114 putative proline-specific permease; Provisional; Region: proY; PRK10580 1095774011115 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1095774011116 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1095774011117 substrate binding site [chemical binding]; other site 1095774011118 THF binding site; other site 1095774011119 zinc-binding site [ion binding]; other site 1095774011120 PBP superfamily domain; Region: PBP_like_2; cl17296 1095774011121 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1095774011122 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1095774011123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1095774011124 putative active site [active] 1095774011125 heme pocket [chemical binding]; other site 1095774011126 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1095774011127 dimer interface [polypeptide binding]; other site 1095774011128 phosphorylation site [posttranslational modification] 1095774011129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774011130 ATP binding site [chemical binding]; other site 1095774011131 Mg2+ binding site [ion binding]; other site 1095774011132 G-X-G motif; other site 1095774011133 transcriptional regulator PhoB; Provisional; Region: PRK10161 1095774011134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774011135 active site 1095774011136 phosphorylation site [posttranslational modification] 1095774011137 intermolecular recognition site; other site 1095774011138 dimerization interface [polypeptide binding]; other site 1095774011139 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1095774011140 DNA binding site [nucleotide binding] 1095774011141 exonuclease subunit SbcD; Provisional; Region: PRK10966 1095774011142 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1095774011143 active site 1095774011144 metal binding site [ion binding]; metal-binding site 1095774011145 DNA binding site [nucleotide binding] 1095774011146 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1095774011147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774011148 AAA domain; Region: AAA_23; pfam13476 1095774011149 Walker A/P-loop; other site 1095774011150 ATP binding site [chemical binding]; other site 1095774011151 Q-loop/lid; other site 1095774011152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774011153 ABC transporter signature motif; other site 1095774011154 Walker B; other site 1095774011155 D-loop; other site 1095774011156 H-loop/switch region; other site 1095774011157 TolA C-terminal; Region: TolA; pfam06519 1095774011158 fructokinase; Reviewed; Region: PRK09557 1095774011159 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1095774011160 nucleotide binding site [chemical binding]; other site 1095774011161 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1095774011162 hypothetical protein; Provisional; Region: PRK10579 1095774011163 hypothetical protein; Provisional; Region: PRK10380 1095774011164 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1095774011165 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1095774011166 ADP binding site [chemical binding]; other site 1095774011167 magnesium binding site [ion binding]; other site 1095774011168 putative shikimate binding site; other site 1095774011169 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1095774011170 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1095774011171 hypothetical protein; Validated; Region: PRK00124 1095774011172 pyrroline-5-carboxylate reductase; Region: PLN02688 1095774011173 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1095774011174 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1095774011175 iron-sulfur cluster [ion binding]; other site 1095774011176 [2Fe-2S] cluster binding site [ion binding]; other site 1095774011177 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1095774011178 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1095774011179 hypothetical protein; Provisional; Region: PRK11505 1095774011180 psiF repeat; Region: PsiF_repeat; pfam07769 1095774011181 psiF repeat; Region: PsiF_repeat; pfam07769 1095774011182 anti-RssB factor; Provisional; Region: PRK10244 1095774011183 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1095774011184 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 1095774011185 CAAX protease self-immunity; Region: Abi; pfam02517 1095774011186 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1095774011187 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774011188 DNA binding site [nucleotide binding] 1095774011189 domain linker motif; other site 1095774011190 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1095774011191 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1095774011192 beta-galactosidase; Region: BGL; TIGR03356 1095774011193 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 1095774011194 active site 1095774011195 methionine cluster; other site 1095774011196 phosphorylation site [posttranslational modification] 1095774011197 metal binding site [ion binding]; metal-binding site 1095774011198 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1095774011199 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1095774011200 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1095774011201 active site 1095774011202 P-loop; other site 1095774011203 phosphorylation site [posttranslational modification] 1095774011204 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1095774011205 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1095774011206 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1095774011207 phosphate binding site [ion binding]; other site 1095774011208 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 1095774011209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774011210 DNA-binding site [nucleotide binding]; DNA binding site 1095774011211 FCD domain; Region: FCD; pfam07729 1095774011212 L-lactate permease; Provisional; Region: PRK10420 1095774011213 glycolate transporter; Provisional; Region: PRK09695 1095774011214 putative cyanate transporter; Provisional; Region: cynX; PRK09705 1095774011215 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774011216 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1095774011217 dimerization interface [polypeptide binding]; other site 1095774011218 putative deaminase; Validated; Region: PRK06846 1095774011219 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1095774011220 active site 1095774011221 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1095774011222 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1095774011223 ATP binding site [chemical binding]; other site 1095774011224 Mg++ binding site [ion binding]; other site 1095774011225 motif III; other site 1095774011226 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1095774011227 nucleotide binding region [chemical binding]; other site 1095774011228 ATP-binding site [chemical binding]; other site 1095774011229 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1095774011230 putative RNA binding site [nucleotide binding]; other site 1095774011231 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 1095774011232 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1095774011233 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1095774011234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774011235 active site 1095774011236 phosphorylation site [posttranslational modification] 1095774011237 intermolecular recognition site; other site 1095774011238 dimerization interface [polypeptide binding]; other site 1095774011239 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1095774011240 DNA-binding site [nucleotide binding]; DNA binding site 1095774011241 RNA-binding motif; other site 1095774011242 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1095774011243 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1095774011244 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774011245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774011246 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 1095774011247 putative substrate binding pocket [chemical binding]; other site 1095774011248 putative dimerization interface [polypeptide binding]; other site 1095774011249 potential frameshift: common BLAST hit: gi|291616460|ref|YP_003519202.1| FhaB 1095774011250 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 1095774011251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 1095774011252 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1095774011253 dimerization domain swap beta strand [polypeptide binding]; other site 1095774011254 regulatory protein interface [polypeptide binding]; other site 1095774011255 active site 1095774011256 regulatory phosphorylation site [posttranslational modification]; other site 1095774011257 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1095774011258 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1095774011259 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 1095774011260 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 1095774011261 Dak1 domain; Region: Dak1; pfam02733 1095774011262 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1095774011263 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1095774011264 dimer interface [polypeptide binding]; other site 1095774011265 active site 1095774011266 metal binding site [ion binding]; metal-binding site 1095774011267 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 1095774011268 PAS domain; Region: PAS; smart00091 1095774011269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774011270 Walker A motif; other site 1095774011271 ATP binding site [chemical binding]; other site 1095774011272 Walker B motif; other site 1095774011273 arginine finger; other site 1095774011274 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1095774011275 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1095774011276 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1095774011277 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1095774011278 catalytic residue [active] 1095774011279 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1095774011280 non-specific DNA binding site [nucleotide binding]; other site 1095774011281 salt bridge; other site 1095774011282 sequence-specific DNA binding site [nucleotide binding]; other site 1095774011283 Predicted transcriptional regulator [Transcription]; Region: COG2932 1095774011284 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1095774011285 Catalytic site [active] 1095774011286 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1095774011287 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1095774011288 putative catalytic cysteine [active] 1095774011289 gamma-glutamyl kinase; Provisional; Region: PRK05429 1095774011290 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1095774011291 nucleotide binding site [chemical binding]; other site 1095774011292 homotetrameric interface [polypeptide binding]; other site 1095774011293 putative phosphate binding site [ion binding]; other site 1095774011294 putative allosteric binding site; other site 1095774011295 PUA domain; Region: PUA; pfam01472 1095774011296 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1095774011297 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1095774011298 trimer interface [polypeptide binding]; other site 1095774011299 eyelet of channel; other site 1095774011300 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 1095774011301 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1095774011302 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1095774011303 active site 1095774011304 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1095774011305 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1095774011306 metal binding site [ion binding]; metal-binding site 1095774011307 dimer interface [polypeptide binding]; other site 1095774011308 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1095774011309 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1095774011310 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1095774011311 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1095774011312 tetramer interface [polypeptide binding]; other site 1095774011313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774011314 catalytic residue [active] 1095774011315 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1095774011316 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1095774011317 Walker A/P-loop; other site 1095774011318 ATP binding site [chemical binding]; other site 1095774011319 Q-loop/lid; other site 1095774011320 ABC transporter signature motif; other site 1095774011321 Walker B; other site 1095774011322 D-loop; other site 1095774011323 H-loop/switch region; other site 1095774011324 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1095774011325 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1095774011326 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1095774011327 TM-ABC transporter signature motif; other site 1095774011328 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 1095774011329 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1095774011330 putative ligand binding site [chemical binding]; other site 1095774011331 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1095774011332 active site 1095774011333 DNA polymerase IV; Validated; Region: PRK02406 1095774011334 DNA binding site [nucleotide binding] 1095774011335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1095774011336 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1095774011337 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1095774011338 putative active site [active] 1095774011339 putative dimer interface [polypeptide binding]; other site 1095774011340 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1095774011341 dimer interface [polypeptide binding]; other site 1095774011342 active site 1095774011343 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1095774011344 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1095774011345 active site 1095774011346 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1095774011347 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1095774011348 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1095774011349 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1095774011350 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1095774011351 Cupin domain; Region: Cupin_2; cl17218 1095774011352 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 1095774011353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1095774011354 motif II; other site 1095774011355 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 1095774011356 intersubunit interface [polypeptide binding]; other site 1095774011357 active site 1095774011358 Zn2+ binding site [ion binding]; other site 1095774011359 methionine aminotransferase; Validated; Region: PRK09082 1095774011360 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1095774011361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774011362 homodimer interface [polypeptide binding]; other site 1095774011363 catalytic residue [active] 1095774011364 C-N hydrolase family amidase; Provisional; Region: PRK10438 1095774011365 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1095774011366 putative active site [active] 1095774011367 catalytic triad [active] 1095774011368 dimer interface [polypeptide binding]; other site 1095774011369 multimer interface [polypeptide binding]; other site 1095774011370 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1095774011371 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1095774011372 heme binding site [chemical binding]; other site 1095774011373 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1095774011374 heme binding site [chemical binding]; other site 1095774011375 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1095774011376 active site 1095774011377 homotetramer interface [polypeptide binding]; other site 1095774011378 OHCU decarboxylase; Region: UraD_2; TIGR03180 1095774011379 allantoate amidohydrolase; Reviewed; Region: PRK09290 1095774011380 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1095774011381 active site 1095774011382 metal binding site [ion binding]; metal-binding site 1095774011383 dimer interface [polypeptide binding]; other site 1095774011384 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1095774011385 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1095774011386 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1095774011387 catalytic residue [active] 1095774011388 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1095774011389 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1095774011390 Walker A/P-loop; other site 1095774011391 ATP binding site [chemical binding]; other site 1095774011392 Q-loop/lid; other site 1095774011393 ABC transporter signature motif; other site 1095774011394 Walker B; other site 1095774011395 D-loop; other site 1095774011396 H-loop/switch region; other site 1095774011397 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 1095774011398 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1095774011399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774011400 dimer interface [polypeptide binding]; other site 1095774011401 conserved gate region; other site 1095774011402 putative PBP binding loops; other site 1095774011403 ABC-ATPase subunit interface; other site 1095774011404 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1095774011405 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774011406 substrate binding pocket [chemical binding]; other site 1095774011407 membrane-bound complex binding site; other site 1095774011408 hinge residues; other site 1095774011409 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1095774011410 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1095774011411 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1095774011412 putative active site [active] 1095774011413 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1095774011414 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1095774011415 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 1095774011416 amidase; Provisional; Region: PRK09201 1095774011417 Amidase; Region: Amidase; pfam01425 1095774011418 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 1095774011419 SnoaL-like domain; Region: SnoaL_3; pfam13474 1095774011420 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1095774011421 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774011422 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1095774011423 dimerization interface [polypeptide binding]; other site 1095774011424 substrate binding pocket [chemical binding]; other site 1095774011425 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1095774011426 acetylornithine deacetylase; Provisional; Region: PRK07522 1095774011427 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1095774011428 metal binding site [ion binding]; metal-binding site 1095774011429 putative dimer interface [polypeptide binding]; other site 1095774011430 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1095774011431 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1095774011432 homotrimer interaction site [polypeptide binding]; other site 1095774011433 putative active site [active] 1095774011434 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1095774011435 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1095774011436 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774011437 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774011438 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1095774011439 putative substrate binding pocket [chemical binding]; other site 1095774011440 dimerization interface [polypeptide binding]; other site 1095774011441 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1095774011442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774011443 dimer interface [polypeptide binding]; other site 1095774011444 conserved gate region; other site 1095774011445 putative PBP binding loops; other site 1095774011446 ABC-ATPase subunit interface; other site 1095774011447 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1095774011448 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774011449 Walker A/P-loop; other site 1095774011450 ATP binding site [chemical binding]; other site 1095774011451 Q-loop/lid; other site 1095774011452 ABC transporter signature motif; other site 1095774011453 Walker B; other site 1095774011454 D-loop; other site 1095774011455 H-loop/switch region; other site 1095774011456 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1095774011457 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1095774011458 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1095774011459 substrate binding pocket [chemical binding]; other site 1095774011460 membrane-bound complex binding site; other site 1095774011461 hinge residues; other site 1095774011462 hypothetical protein; Provisional; Region: PRK07490 1095774011463 intersubunit interface [polypeptide binding]; other site 1095774011464 active site 1095774011465 Zn2+ binding site [ion binding]; other site 1095774011466 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1095774011467 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1095774011468 active site 1095774011469 catalytic site [active] 1095774011470 tetramer interface [polypeptide binding]; other site 1095774011471 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 1095774011472 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1095774011473 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774011474 DNA-binding site [nucleotide binding]; DNA binding site 1095774011475 FCD domain; Region: FCD; pfam07729 1095774011476 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1095774011477 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1095774011478 Na binding site [ion binding]; other site 1095774011479 putative substrate binding site [chemical binding]; other site 1095774011480 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 1095774011481 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1095774011482 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1095774011483 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1095774011484 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1095774011485 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 1095774011486 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 1095774011487 putative NAD(P) binding site [chemical binding]; other site 1095774011488 active site 1095774011489 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1095774011490 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1095774011491 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1095774011492 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1095774011493 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1095774011494 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1095774011495 putative active site [active] 1095774011496 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1095774011497 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1095774011498 active site 1095774011499 intersubunit interactions; other site 1095774011500 catalytic residue [active] 1095774011501 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1095774011502 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1095774011503 active site 1095774011504 catalytic site [active] 1095774011505 substrate binding site [chemical binding]; other site 1095774011506 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1095774011507 RNA/DNA hybrid binding site [nucleotide binding]; other site 1095774011508 active site 1095774011509 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1095774011510 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1095774011511 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1095774011512 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1095774011513 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1095774011514 catalytic residue [active] 1095774011515 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1095774011516 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1095774011517 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1095774011518 hypothetical protein; Provisional; Region: PRK05421 1095774011519 putative catalytic site [active] 1095774011520 putative metal binding site [ion binding]; other site 1095774011521 putative phosphate binding site [ion binding]; other site 1095774011522 putative catalytic site [active] 1095774011523 putative phosphate binding site [ion binding]; other site 1095774011524 putative metal binding site [ion binding]; other site 1095774011525 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774011526 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1095774011527 dimerization interface [polypeptide binding]; other site 1095774011528 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1095774011529 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774011530 active site 1095774011531 motif I; other site 1095774011532 motif II; other site 1095774011533 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1095774011534 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1095774011535 Walker A/P-loop; other site 1095774011536 ATP binding site [chemical binding]; other site 1095774011537 Q-loop/lid; other site 1095774011538 ABC transporter signature motif; other site 1095774011539 Walker B; other site 1095774011540 D-loop; other site 1095774011541 H-loop/switch region; other site 1095774011542 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1095774011543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774011544 dimer interface [polypeptide binding]; other site 1095774011545 conserved gate region; other site 1095774011546 ABC-ATPase subunit interface; other site 1095774011547 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1095774011548 lipoprotein, YaeC family; Region: TIGR00363 1095774011549 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1095774011550 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1095774011551 homodimer interaction site [polypeptide binding]; other site 1095774011552 cofactor binding site; other site 1095774011553 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1095774011554 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1095774011555 dimer interface [polypeptide binding]; other site 1095774011556 motif 1; other site 1095774011557 active site 1095774011558 motif 2; other site 1095774011559 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1095774011560 putative deacylase active site [active] 1095774011561 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1095774011562 active site 1095774011563 motif 3; other site 1095774011564 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1095774011565 anticodon binding site; other site 1095774011566 hypothetical protein; Provisional; Region: PRK09256 1095774011567 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1095774011568 hypothetical protein; Provisional; Region: PRK04964 1095774011569 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 1095774011570 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1095774011571 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1095774011572 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1095774011573 Ligand Binding Site [chemical binding]; other site 1095774011574 TilS substrate binding domain; Region: TilS; pfam09179 1095774011575 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1095774011576 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1095774011577 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1095774011578 putative metal binding site [ion binding]; other site 1095774011579 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1095774011580 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1095774011581 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1095774011582 homodimer interface [polypeptide binding]; other site 1095774011583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774011584 catalytic residue [active] 1095774011585 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1095774011586 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1095774011587 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1095774011588 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1095774011589 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1095774011590 putative active site [active] 1095774011591 putative PHP Thumb interface [polypeptide binding]; other site 1095774011592 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1095774011593 generic binding surface II; other site 1095774011594 generic binding surface I; other site 1095774011595 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1095774011596 RNA/DNA hybrid binding site [nucleotide binding]; other site 1095774011597 active site 1095774011598 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1095774011599 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1095774011600 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1095774011601 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1095774011602 active site 1095774011603 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1095774011604 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1095774011605 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1095774011606 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1095774011607 trimer interface [polypeptide binding]; other site 1095774011608 active site 1095774011609 UDP-GlcNAc binding site [chemical binding]; other site 1095774011610 lipid binding site [chemical binding]; lipid-binding site 1095774011611 periplasmic chaperone; Provisional; Region: PRK10780 1095774011612 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1095774011613 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1095774011614 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1095774011615 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1095774011616 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1095774011617 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1095774011618 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1095774011619 Surface antigen; Region: Bac_surface_Ag; pfam01103 1095774011620 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1095774011621 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1095774011622 active site 1095774011623 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1095774011624 protein binding site [polypeptide binding]; other site 1095774011625 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1095774011626 protein binding site [polypeptide binding]; other site 1095774011627 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1095774011628 putative substrate binding region [chemical binding]; other site 1095774011629 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1095774011630 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1095774011631 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1095774011632 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1095774011633 catalytic residue [active] 1095774011634 putative FPP diphosphate binding site; other site 1095774011635 putative FPP binding hydrophobic cleft; other site 1095774011636 dimer interface [polypeptide binding]; other site 1095774011637 putative IPP diphosphate binding site; other site 1095774011638 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1095774011639 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1095774011640 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1095774011641 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1095774011642 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1095774011643 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1095774011644 hinge region; other site 1095774011645 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1095774011646 putative nucleotide binding site [chemical binding]; other site 1095774011647 uridine monophosphate binding site [chemical binding]; other site 1095774011648 homohexameric interface [polypeptide binding]; other site 1095774011649 elongation factor Ts; Provisional; Region: tsf; PRK09377 1095774011650 UBA/TS-N domain; Region: UBA; pfam00627 1095774011651 Elongation factor TS; Region: EF_TS; pfam00889 1095774011652 Elongation factor TS; Region: EF_TS; pfam00889 1095774011653 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1095774011654 rRNA interaction site [nucleotide binding]; other site 1095774011655 S8 interaction site; other site 1095774011656 putative laminin-1 binding site; other site 1095774011657 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1095774011658 active site 1095774011659 PII uridylyl-transferase; Provisional; Region: PRK05007 1095774011660 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1095774011661 metal binding triad; other site 1095774011662 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1095774011663 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1095774011664 Zn2+ binding site [ion binding]; other site 1095774011665 Mg2+ binding site [ion binding]; other site 1095774011666 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1095774011667 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1095774011668 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1095774011669 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1095774011670 trimer interface [polypeptide binding]; other site 1095774011671 active site 1095774011672 substrate binding site [chemical binding]; other site 1095774011673 CoA binding site [chemical binding]; other site 1095774011674 hypothetical protein; Provisional; Region: PRK13677 1095774011675 Alginate lyase; Region: Alginate_lyase; pfam05426 1095774011676 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 1095774011677 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1095774011678 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1095774011679 serine endoprotease; Provisional; Region: PRK10942 1095774011680 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1095774011681 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1095774011682 protein binding site [polypeptide binding]; other site 1095774011683 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1095774011684 protein binding site [polypeptide binding]; other site 1095774011685 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1095774011686 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1095774011687 Zn2+ binding site [ion binding]; other site 1095774011688 Mg2+ binding site [ion binding]; other site 1095774011689 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1095774011690 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1095774011691 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1095774011692 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1095774011693 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1095774011694 cobalamin binding residues [chemical binding]; other site 1095774011695 putative BtuC binding residues; other site 1095774011696 dimer interface [polypeptide binding]; other site 1095774011697 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1095774011698 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1095774011699 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1095774011700 inhibitor-cofactor binding pocket; inhibition site 1095774011701 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774011702 catalytic residue [active] 1095774011703 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1095774011704 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1095774011705 ABC-ATPase subunit interface; other site 1095774011706 dimer interface [polypeptide binding]; other site 1095774011707 putative PBP binding regions; other site 1095774011708 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1095774011709 ABC-ATPase subunit interface; other site 1095774011710 dimer interface [polypeptide binding]; other site 1095774011711 putative PBP binding regions; other site 1095774011712 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1095774011713 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1095774011714 siderophore binding site; other site 1095774011715 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1095774011716 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1095774011717 Walker A/P-loop; other site 1095774011718 ATP binding site [chemical binding]; other site 1095774011719 Q-loop/lid; other site 1095774011720 ABC transporter signature motif; other site 1095774011721 Walker B; other site 1095774011722 D-loop; other site 1095774011723 H-loop/switch region; other site 1095774011724 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1095774011725 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1095774011726 N-terminal plug; other site 1095774011727 ligand-binding site [chemical binding]; other site 1095774011728 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1095774011729 Transglycosylase; Region: Transgly; pfam00912 1095774011730 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1095774011731 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1095774011732 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1095774011733 ATP binding site [chemical binding]; other site 1095774011734 putative Mg++ binding site [ion binding]; other site 1095774011735 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1095774011736 nucleotide binding region [chemical binding]; other site 1095774011737 ATP-binding site [chemical binding]; other site 1095774011738 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1095774011739 2'-5' RNA ligase; Provisional; Region: PRK15124 1095774011740 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1095774011741 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1095774011742 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1095774011743 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 1095774011744 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1095774011745 active site 1095774011746 nucleotide binding site [chemical binding]; other site 1095774011747 HIGH motif; other site 1095774011748 KMSKS motif; other site 1095774011749 poly(A) polymerase; Region: pcnB; TIGR01942 1095774011750 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1095774011751 active site 1095774011752 NTP binding site [chemical binding]; other site 1095774011753 metal binding triad [ion binding]; metal-binding site 1095774011754 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1095774011755 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1095774011756 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1095774011757 catalytic center binding site [active] 1095774011758 ATP binding site [chemical binding]; other site 1095774011759 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1095774011760 oligomerization interface [polypeptide binding]; other site 1095774011761 active site 1095774011762 metal binding site [ion binding]; metal-binding site 1095774011763 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1095774011764 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1095774011765 active site 1095774011766 ATP-binding site [chemical binding]; other site 1095774011767 pantoate-binding site; other site 1095774011768 HXXH motif; other site 1095774011769 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1095774011770 tetramerization interface [polypeptide binding]; other site 1095774011771 active site 1095774011772 inner membrane transport permease; Provisional; Region: PRK15066 1095774011773 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1095774011774 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1095774011775 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1095774011776 Walker A/P-loop; other site 1095774011777 ATP binding site [chemical binding]; other site 1095774011778 Q-loop/lid; other site 1095774011779 ABC transporter signature motif; other site 1095774011780 Walker B; other site 1095774011781 D-loop; other site 1095774011782 H-loop/switch region; other site 1095774011783 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1095774011784 active site clefts [active] 1095774011785 zinc binding site [ion binding]; other site 1095774011786 dimer interface [polypeptide binding]; other site 1095774011787 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1095774011788 active site 1095774011789 methionine gamma-lyase; Validated; Region: PRK07049 1095774011790 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1095774011791 homodimer interface [polypeptide binding]; other site 1095774011792 substrate-cofactor binding pocket; other site 1095774011793 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774011794 catalytic residue [active] 1095774011795 multicopper oxidase; Provisional; Region: PRK10965 1095774011796 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1095774011797 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1095774011798 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1095774011799 spermidine synthase; Provisional; Region: PRK00811 1095774011800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774011801 S-adenosylmethionine binding site [chemical binding]; other site 1095774011802 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1095774011803 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1095774011804 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1095774011805 active site 1095774011806 TDP-binding site; other site 1095774011807 acceptor substrate-binding pocket; other site 1095774011808 CHASE3 domain; Region: CHASE3; pfam05227 1095774011809 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1095774011810 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774011811 dimerization interface [polypeptide binding]; other site 1095774011812 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774011813 dimer interface [polypeptide binding]; other site 1095774011814 putative CheW interface [polypeptide binding]; other site 1095774011815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1095774011816 2-keto-3-deoxygluconate permease; Provisional; Region: PRK12460 1095774011817 hypothetical protein; Provisional; Region: PRK05248 1095774011818 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1095774011819 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1095774011820 substrate binding site [chemical binding]; other site 1095774011821 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1095774011822 substrate binding site [chemical binding]; other site 1095774011823 ligand binding site [chemical binding]; other site 1095774011824 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1095774011825 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1095774011826 active site 1095774011827 catalytic tetrad [active] 1095774011828 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774011829 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774011830 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1095774011831 putative effector binding pocket; other site 1095774011832 putative dimerization interface [polypeptide binding]; other site 1095774011833 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1095774011834 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1095774011835 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1095774011836 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1095774011837 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1095774011838 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1095774011839 E3 interaction surface; other site 1095774011840 lipoyl attachment site [posttranslational modification]; other site 1095774011841 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1095774011842 E3 interaction surface; other site 1095774011843 lipoyl attachment site [posttranslational modification]; other site 1095774011844 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1095774011845 E3 interaction surface; other site 1095774011846 lipoyl attachment site [posttranslational modification]; other site 1095774011847 e3 binding domain; Region: E3_binding; pfam02817 1095774011848 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1095774011849 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1095774011850 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1095774011851 dimer interface [polypeptide binding]; other site 1095774011852 TPP-binding site [chemical binding]; other site 1095774011853 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1095774011854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774011855 DNA-binding site [nucleotide binding]; DNA binding site 1095774011856 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1095774011857 aromatic amino acid transporter; Provisional; Region: PRK10238 1095774011858 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1095774011859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774011860 putative substrate translocation pore; other site 1095774011861 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1095774011862 active site 1095774011863 regulatory protein AmpE; Provisional; Region: PRK10987 1095774011864 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1095774011865 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1095774011866 amidase catalytic site [active] 1095774011867 substrate binding site [chemical binding]; other site 1095774011868 Zn binding residues [ion binding]; other site 1095774011869 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1095774011870 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1095774011871 dimerization interface [polypeptide binding]; other site 1095774011872 active site 1095774011873 putative major pilin subunit; Provisional; Region: PRK10574 1095774011874 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1095774011875 Pilin (bacterial filament); Region: Pilin; pfam00114 1095774011876 hypothetical protein; Provisional; Region: PRK10436 1095774011877 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1095774011878 Walker A motif; other site 1095774011879 ATP binding site [chemical binding]; other site 1095774011880 Walker B motif; other site 1095774011881 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1095774011882 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1095774011883 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1095774011884 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1095774011885 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1095774011886 active site 1095774011887 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1095774011888 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1095774011889 CoA-binding site [chemical binding]; other site 1095774011890 ATP-binding [chemical binding]; other site 1095774011891 hypothetical protein; Provisional; Region: PRK05287 1095774011892 Domain of unknown function (DUF329); Region: DUF329; cl01144 1095774011893 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1095774011894 active site 1095774011895 8-oxo-dGMP binding site [chemical binding]; other site 1095774011896 nudix motif; other site 1095774011897 metal binding site [ion binding]; metal-binding site 1095774011898 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1095774011899 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1095774011900 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1095774011901 SEC-C motif; Region: SEC-C; pfam02810 1095774011902 SecA regulator SecM; Provisional; Region: PRK02943 1095774011903 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1095774011904 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1095774011905 cell division protein FtsZ; Validated; Region: PRK09330 1095774011906 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1095774011907 nucleotide binding site [chemical binding]; other site 1095774011908 SulA interaction site; other site 1095774011909 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1095774011910 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1095774011911 Cell division protein FtsA; Region: FtsA; pfam14450 1095774011912 cell division protein FtsQ; Provisional; Region: PRK10775 1095774011913 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1095774011914 Cell division protein FtsQ; Region: FtsQ; pfam03799 1095774011915 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1095774011916 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1095774011917 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1095774011918 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1095774011919 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1095774011920 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1095774011921 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1095774011922 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1095774011923 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1095774011924 active site 1095774011925 homodimer interface [polypeptide binding]; other site 1095774011926 cell division protein FtsW; Provisional; Region: PRK10774 1095774011927 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1095774011928 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1095774011929 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1095774011930 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1095774011931 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1095774011932 Mg++ binding site [ion binding]; other site 1095774011933 putative catalytic motif [active] 1095774011934 putative substrate binding site [chemical binding]; other site 1095774011935 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1095774011936 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1095774011937 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1095774011938 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1095774011939 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1095774011940 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1095774011941 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1095774011942 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1095774011943 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1095774011944 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1095774011945 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1095774011946 cell division protein FtsL; Provisional; Region: PRK10772 1095774011947 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1095774011948 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1095774011949 cell division protein MraZ; Reviewed; Region: PRK00326 1095774011950 MraZ protein; Region: MraZ; pfam02381 1095774011951 MraZ protein; Region: MraZ; pfam02381 1095774011952 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1095774011953 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774011954 DNA binding site [nucleotide binding] 1095774011955 domain linker motif; other site 1095774011956 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1095774011957 dimerization interface [polypeptide binding]; other site 1095774011958 ligand binding site [chemical binding]; other site 1095774011959 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1095774011960 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1095774011961 putative valine binding site [chemical binding]; other site 1095774011962 dimer interface [polypeptide binding]; other site 1095774011963 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1095774011964 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 1095774011965 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1095774011966 PYR/PP interface [polypeptide binding]; other site 1095774011967 dimer interface [polypeptide binding]; other site 1095774011968 TPP binding site [chemical binding]; other site 1095774011969 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1095774011970 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1095774011971 TPP-binding site [chemical binding]; other site 1095774011972 dimer interface [polypeptide binding]; other site 1095774011973 2-isopropylmalate synthase; Validated; Region: PRK00915 1095774011974 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1095774011975 active site 1095774011976 catalytic residues [active] 1095774011977 metal binding site [ion binding]; metal-binding site 1095774011978 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1095774011979 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1095774011980 tartrate dehydrogenase; Provisional; Region: PRK08194 1095774011981 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1095774011982 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1095774011983 substrate binding site [chemical binding]; other site 1095774011984 ligand binding site [chemical binding]; other site 1095774011985 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1095774011986 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1095774011987 substrate binding site [chemical binding]; other site 1095774011988 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1095774011989 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1095774011990 active site 1095774011991 FMN binding site [chemical binding]; other site 1095774011992 substrate binding site [chemical binding]; other site 1095774011993 putative catalytic residue [active] 1095774011994 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1095774011995 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1095774011996 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 1095774011997 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1095774011998 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1095774011999 shikimate binding site; other site 1095774012000 NAD(P) binding site [chemical binding]; other site 1095774012001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774012002 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1095774012003 putative substrate translocation pore; other site 1095774012004 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1095774012005 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1095774012006 active site 1095774012007 catalytic residue [active] 1095774012008 dimer interface [polypeptide binding]; other site 1095774012009 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774012010 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774012011 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1095774012012 putative dimerization interface [polypeptide binding]; other site 1095774012013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774012014 D-galactonate transporter; Region: 2A0114; TIGR00893 1095774012015 putative substrate translocation pore; other site 1095774012016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774012017 sugar efflux transporter; Region: 2A0120; TIGR00899 1095774012018 putative substrate translocation pore; other site 1095774012019 transcriptional regulator SgrR; Provisional; Region: PRK13626 1095774012020 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1095774012021 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1095774012022 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1095774012023 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1095774012024 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1095774012025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774012026 dimer interface [polypeptide binding]; other site 1095774012027 conserved gate region; other site 1095774012028 putative PBP binding loops; other site 1095774012029 ABC-ATPase subunit interface; other site 1095774012030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774012031 dimer interface [polypeptide binding]; other site 1095774012032 conserved gate region; other site 1095774012033 putative PBP binding loops; other site 1095774012034 ABC-ATPase subunit interface; other site 1095774012035 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1095774012036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774012037 Walker A/P-loop; other site 1095774012038 ATP binding site [chemical binding]; other site 1095774012039 Q-loop/lid; other site 1095774012040 ABC transporter signature motif; other site 1095774012041 Walker B; other site 1095774012042 D-loop; other site 1095774012043 H-loop/switch region; other site 1095774012044 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1095774012045 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1095774012046 DNA polymerase II; Reviewed; Region: PRK05762 1095774012047 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1095774012048 active site 1095774012049 catalytic site [active] 1095774012050 substrate binding site [chemical binding]; other site 1095774012051 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1095774012052 active site 1095774012053 metal-binding site 1095774012054 ATP-dependent helicase HepA; Validated; Region: PRK04914 1095774012055 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1095774012056 ATP binding site [chemical binding]; other site 1095774012057 putative Mg++ binding site [ion binding]; other site 1095774012058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1095774012059 nucleotide binding region [chemical binding]; other site 1095774012060 ATP-binding site [chemical binding]; other site 1095774012061 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1095774012062 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1095774012063 active site 1095774012064 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1095774012065 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1095774012066 putative metal binding site [ion binding]; other site 1095774012067 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1095774012068 HSP70 interaction site [polypeptide binding]; other site 1095774012069 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1095774012070 OstA-like protein; Region: OstA; pfam03968 1095774012071 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1095774012072 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1095774012073 SurA N-terminal domain; Region: SurA_N; pfam09312 1095774012074 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1095774012075 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1095774012076 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1095774012077 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1095774012078 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1095774012079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774012080 S-adenosylmethionine binding site [chemical binding]; other site 1095774012081 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1095774012082 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1095774012083 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1095774012084 active site 1095774012085 metal binding site [ion binding]; metal-binding site 1095774012086 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1095774012087 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1095774012088 folate binding site [chemical binding]; other site 1095774012089 NADP+ binding site [chemical binding]; other site 1095774012090 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1095774012091 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1095774012092 eyelet of channel; other site 1095774012093 trimer interface [polypeptide binding]; other site 1095774012094 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774012095 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774012096 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1095774012097 dimerization interface [polypeptide binding]; other site 1095774012098 putative effector binding pocket; other site 1095774012099 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 1095774012100 NAD(P) binding site [chemical binding]; other site 1095774012101 active site 1095774012102 Mig-14; Region: Mig-14; pfam07395 1095774012103 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1095774012104 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1095774012105 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1095774012106 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1095774012107 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1095774012108 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1095774012109 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1095774012110 IMP binding site; other site 1095774012111 dimer interface [polypeptide binding]; other site 1095774012112 interdomain contacts; other site 1095774012113 partial ornithine binding site; other site 1095774012114 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1095774012115 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1095774012116 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1095774012117 catalytic site [active] 1095774012118 subunit interface [polypeptide binding]; other site 1095774012119 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1095774012120 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1095774012121 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1095774012122 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1095774012123 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1095774012124 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1095774012125 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1095774012126 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1095774012127 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1095774012128 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1095774012129 active site 1095774012130 HIGH motif; other site 1095774012131 nucleotide binding site [chemical binding]; other site 1095774012132 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1095774012133 active site 1095774012134 KMSKS motif; other site 1095774012135 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1095774012136 tRNA binding surface [nucleotide binding]; other site 1095774012137 anticodon binding site; other site 1095774012138 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1095774012139 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1095774012140 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1095774012141 active site 1095774012142 Riboflavin kinase; Region: Flavokinase; smart00904 1095774012143 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1095774012144 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1095774012145 chaperone protein DnaJ; Provisional; Region: PRK10767 1095774012146 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1095774012147 HSP70 interaction site [polypeptide binding]; other site 1095774012148 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1095774012149 substrate binding site [polypeptide binding]; other site 1095774012150 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1095774012151 Zn binding sites [ion binding]; other site 1095774012152 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1095774012153 dimer interface [polypeptide binding]; other site 1095774012154 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1095774012155 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1095774012156 nucleotide binding site [chemical binding]; other site 1095774012157 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 1095774012158 metabolite-proton symporter; Region: 2A0106; TIGR00883 1095774012159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774012160 putative substrate translocation pore; other site 1095774012161 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1095774012162 MPT binding site; other site 1095774012163 trimer interface [polypeptide binding]; other site 1095774012164 transaldolase-like protein; Provisional; Region: PTZ00411 1095774012165 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1095774012166 active site 1095774012167 dimer interface [polypeptide binding]; other site 1095774012168 catalytic residue [active] 1095774012169 hypothetical protein; Validated; Region: PRK02101 1095774012170 threonine synthase; Validated; Region: PRK09225 1095774012171 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1095774012172 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1095774012173 catalytic residue [active] 1095774012174 homoserine kinase; Provisional; Region: PRK01212 1095774012175 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1095774012176 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1095774012177 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1095774012178 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1095774012179 putative catalytic residues [active] 1095774012180 putative nucleotide binding site [chemical binding]; other site 1095774012181 putative aspartate binding site [chemical binding]; other site 1095774012182 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1095774012183 dimer interface [polypeptide binding]; other site 1095774012184 putative threonine allosteric regulatory site; other site 1095774012185 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1095774012186 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1095774012187 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1095774012188 putative RNA methyltransferase; Provisional; Region: PRK10433 1095774012189 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1095774012190 two-component response regulator; Provisional; Region: PRK11173 1095774012191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774012192 active site 1095774012193 phosphorylation site [posttranslational modification] 1095774012194 intermolecular recognition site; other site 1095774012195 dimerization interface [polypeptide binding]; other site 1095774012196 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1095774012197 DNA binding site [nucleotide binding] 1095774012198 hypothetical protein; Provisional; Region: PRK10756 1095774012199 CreA protein; Region: CreA; pfam05981 1095774012200 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1095774012201 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774012202 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1095774012203 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1095774012204 catalytic core [active] 1095774012205 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1095774012206 Trp operon repressor; Provisional; Region: PRK01381 1095774012207 lytic murein transglycosylase; Provisional; Region: PRK11619 1095774012208 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1095774012209 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1095774012210 catalytic residue [active] 1095774012211 allophanate hydrolase; Provisional; Region: PRK08186 1095774012212 Amidase; Region: Amidase; cl11426 1095774012213 urea carboxylase; Region: urea_carbox; TIGR02712 1095774012214 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1095774012215 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1095774012216 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1095774012217 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1095774012218 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1095774012219 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1095774012220 carboxyltransferase (CT) interaction site; other site 1095774012221 biotinylation site [posttranslational modification]; other site 1095774012222 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1095774012223 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774012224 DNA-binding site [nucleotide binding]; DNA binding site 1095774012225 FCD domain; Region: FCD; pfam07729 1095774012226 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1095774012227 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1095774012228 putative ligand binding site [chemical binding]; other site 1095774012229 HEAT repeats; Region: HEAT_2; pfam13646 1095774012230 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1095774012231 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1095774012232 TM-ABC transporter signature motif; other site 1095774012233 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1095774012234 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1095774012235 TM-ABC transporter signature motif; other site 1095774012236 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1095774012237 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1095774012238 Walker A/P-loop; other site 1095774012239 ATP binding site [chemical binding]; other site 1095774012240 Q-loop/lid; other site 1095774012241 ABC transporter signature motif; other site 1095774012242 Walker B; other site 1095774012243 D-loop; other site 1095774012244 H-loop/switch region; other site 1095774012245 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1095774012246 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1095774012247 Walker A/P-loop; other site 1095774012248 ATP binding site [chemical binding]; other site 1095774012249 Q-loop/lid; other site 1095774012250 ABC transporter signature motif; other site 1095774012251 Walker B; other site 1095774012252 D-loop; other site 1095774012253 H-loop/switch region; other site 1095774012254 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1095774012255 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1095774012256 N-terminal plug; other site 1095774012257 ligand-binding site [chemical binding]; other site 1095774012258 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 1095774012259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774012260 putative substrate translocation pore; other site 1095774012261 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1095774012262 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1095774012263 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1095774012264 IucA / IucC family; Region: IucA_IucC; pfam04183 1095774012265 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1095774012266 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1095774012267 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1095774012268 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1095774012269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774012270 catalytic residue [active] 1095774012271 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 1095774012272 active site 1095774012273 catalytic residues [active] 1095774012274 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1095774012275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774012276 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1095774012277 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1095774012278 substrate binding site [chemical binding]; other site 1095774012279 dimer interface [polypeptide binding]; other site 1095774012280 ATP binding site [chemical binding]; other site 1095774012281 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1095774012282 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1095774012283 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1095774012284 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1095774012285 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1095774012286 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1095774012287 ABC transporter; Region: ABC_tran_2; pfam12848 1095774012288 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1095774012289 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774012290 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774012291 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1095774012292 putative effector binding pocket; other site 1095774012293 dimerization interface [polypeptide binding]; other site 1095774012294 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1095774012295 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1095774012296 putative NAD(P) binding site [chemical binding]; other site 1095774012297 dimer interface [polypeptide binding]; other site 1095774012298 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1095774012299 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1095774012300 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1095774012301 Fimbrial protein; Region: Fimbrial; cl01416 1095774012302 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1095774012303 PapC N-terminal domain; Region: PapC_N; pfam13954 1095774012304 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1095774012305 PapC C-terminal domain; Region: PapC_C; pfam13953 1095774012306 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1095774012307 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1095774012308 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1095774012309 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1095774012310 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1095774012311 DNA binding site [nucleotide binding] 1095774012312 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1095774012313 non-specific DNA binding site [nucleotide binding]; other site 1095774012314 salt bridge; other site 1095774012315 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1095774012316 sequence-specific DNA binding site [nucleotide binding]; other site 1095774012317 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1095774012318 active site 1095774012319 (T/H)XGH motif; other site 1095774012320 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1095774012321 DNA repair protein RadA; Region: sms; TIGR00416 1095774012322 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1095774012323 Walker A motif/ATP binding site; other site 1095774012324 ATP binding site [chemical binding]; other site 1095774012325 Walker B motif; other site 1095774012326 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1095774012327 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1095774012328 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774012329 motif II; other site 1095774012330 hypothetical protein; Provisional; Region: PRK11246 1095774012331 dUMP phosphatase; Provisional; Region: PRK09449 1095774012332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774012333 motif II; other site 1095774012334 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1095774012335 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774012336 Coenzyme A binding pocket [chemical binding]; other site 1095774012337 DNA polymerase III subunit psi; Validated; Region: PRK06856 1095774012338 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1095774012339 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1095774012340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774012341 S-adenosylmethionine binding site [chemical binding]; other site 1095774012342 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 1095774012343 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1095774012344 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1095774012345 metal binding site [ion binding]; metal-binding site 1095774012346 active site 1095774012347 I-site; other site 1095774012348 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1095774012349 putative deacylase active site [active] 1095774012350 putative sialic acid transporter; Region: 2A0112; TIGR00891 1095774012351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774012352 putative substrate translocation pore; other site 1095774012353 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 1095774012354 active site 1095774012355 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1095774012356 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774012357 DNA binding site [nucleotide binding] 1095774012358 domain linker motif; other site 1095774012359 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1095774012360 dimerization interface [polypeptide binding]; other site 1095774012361 ligand binding site [chemical binding]; other site 1095774012362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774012363 metabolite-proton symporter; Region: 2A0106; TIGR00883 1095774012364 putative substrate translocation pore; other site 1095774012365 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 1095774012366 catalytic core [active] 1095774012367 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1095774012368 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1095774012369 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 1095774012370 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1095774012371 phosphoglycerol transferase I; Provisional; Region: PRK03776 1095774012372 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1095774012373 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 1095774012374 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1095774012375 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1095774012376 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 1095774012377 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1095774012378 Beta-lactamase; Region: Beta-lactamase; pfam00144 1095774012379 hypothetical protein; Provisional; Region: PRK10396 1095774012380 yecA family protein; Region: ygfB_yecA; TIGR02292 1095774012381 SEC-C motif; Region: SEC-C; pfam02810 1095774012382 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1095774012383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774012384 DNA-binding site [nucleotide binding]; DNA binding site 1095774012385 FCD domain; Region: FCD; pfam07729 1095774012386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774012387 metabolite-proton symporter; Region: 2A0106; TIGR00883 1095774012388 putative substrate translocation pore; other site 1095774012389 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1095774012390 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1095774012391 putative NAD(P) binding site [chemical binding]; other site 1095774012392 catalytic Zn binding site [ion binding]; other site 1095774012393 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 1095774012394 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1095774012395 NADP binding site [chemical binding]; other site 1095774012396 homodimer interface [polypeptide binding]; other site 1095774012397 active site 1095774012398 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1095774012399 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1095774012400 metal binding site [ion binding]; metal-binding site 1095774012401 substrate binding pocket [chemical binding]; other site 1095774012402 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1095774012403 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1095774012404 Walker A/P-loop; other site 1095774012405 ATP binding site [chemical binding]; other site 1095774012406 Q-loop/lid; other site 1095774012407 ABC transporter signature motif; other site 1095774012408 Walker B; other site 1095774012409 D-loop; other site 1095774012410 H-loop/switch region; other site 1095774012411 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 1095774012412 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 1095774012413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774012414 dimer interface [polypeptide binding]; other site 1095774012415 conserved gate region; other site 1095774012416 putative PBP binding loops; other site 1095774012417 ABC-ATPase subunit interface; other site 1095774012418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774012419 dimer interface [polypeptide binding]; other site 1095774012420 conserved gate region; other site 1095774012421 putative PBP binding loops; other site 1095774012422 ABC-ATPase subunit interface; other site 1095774012423 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1095774012424 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1095774012425 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1095774012426 NADP binding site [chemical binding]; other site 1095774012427 homodimer interface [polypeptide binding]; other site 1095774012428 active site 1095774012429 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1095774012430 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1095774012431 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1095774012432 inhibitor-cofactor binding pocket; inhibition site 1095774012433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774012434 catalytic residue [active] 1095774012435 ethanolamine permease; Region: 2A0305; TIGR00908 1095774012436 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1095774012437 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1095774012438 active site 1095774012439 substrate binding site [chemical binding]; other site 1095774012440 ATP binding site [chemical binding]; other site 1095774012441 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1095774012442 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1095774012443 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774012444 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1095774012445 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1095774012446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774012447 Coenzyme A binding pocket [chemical binding]; other site 1095774012448 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 1095774012449 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1095774012450 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1095774012451 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 1095774012452 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1095774012453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774012454 D-galactonate transporter; Region: 2A0114; TIGR00893 1095774012455 putative substrate translocation pore; other site 1095774012456 Domain of unknown function (DUF386); Region: DUF386; cl01047 1095774012457 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1095774012458 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1095774012459 inhibitor site; inhibition site 1095774012460 active site 1095774012461 dimer interface [polypeptide binding]; other site 1095774012462 catalytic residue [active] 1095774012463 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1095774012464 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1095774012465 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1095774012466 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1095774012467 substrate binding site [chemical binding]; other site 1095774012468 dimer interface [polypeptide binding]; other site 1095774012469 ATP binding site [chemical binding]; other site 1095774012470 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 1095774012471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774012472 D-galactonate transporter; Region: 2A0114; TIGR00893 1095774012473 putative substrate translocation pore; other site 1095774012474 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1095774012475 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1095774012476 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774012477 dimer interface [polypeptide binding]; other site 1095774012478 putative CheW interface [polypeptide binding]; other site 1095774012479 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 1095774012480 Protein of unknown function (DUF796); Region: DUF796; cl01226 1095774012481 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1095774012482 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1095774012483 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1095774012484 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774012485 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1095774012486 hypothetical protein; Provisional; Region: PRK07206 1095774012487 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1095774012488 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1095774012489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774012490 S-adenosylmethionine binding site [chemical binding]; other site 1095774012491 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 1095774012492 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 1095774012493 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1095774012494 metal ion-dependent adhesion site (MIDAS); other site 1095774012495 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1095774012496 active site 1095774012497 ATP binding site [chemical binding]; other site 1095774012498 substrate binding site [chemical binding]; other site 1095774012499 activation loop (A-loop); other site 1095774012500 putative transposase OrfB; Reviewed; Region: PHA02517 1095774012501 HTH-like domain; Region: HTH_21; pfam13276 1095774012502 Integrase core domain; Region: rve; pfam00665 1095774012503 Integrase core domain; Region: rve_3; pfam13683 1095774012504 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1095774012505 Transposase; Region: HTH_Tnp_1; cl17663 1095774012506 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1095774012507 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1095774012508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774012509 S-adenosylmethionine binding site [chemical binding]; other site 1095774012510 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1095774012511 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1095774012512 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1095774012513 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1095774012514 ATP binding site [chemical binding]; other site 1095774012515 putative Mg++ binding site [ion binding]; other site 1095774012516 integrase; Provisional; Region: PRK09692 1095774012517 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1095774012518 active site 1095774012519 Int/Topo IB signature motif; other site 1095774012520 hypothetical protein; Provisional; Region: PRK11667 1095774012521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1095774012522 inner membrane protein; Provisional; Region: PRK10995 1095774012523 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1095774012524 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1095774012525 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1095774012526 Zonular occludens toxin (Zot); Region: Zot; cl17485 1095774012527 HipA N-terminal domain; Region: Couple_hipA; cl11853 1095774012528 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1095774012529 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1095774012530 Predicted membrane protein [Function unknown]; Region: COG2733 1095774012531 BtpA family; Region: BtpA; cl00440 1095774012532 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1095774012533 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1095774012534 substrate binding site [chemical binding]; other site 1095774012535 dimer interface [polypeptide binding]; other site 1095774012536 ATP binding site [chemical binding]; other site 1095774012537 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1095774012538 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1095774012539 ligand binding site [chemical binding]; other site 1095774012540 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1095774012541 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774012542 DNA binding site [nucleotide binding] 1095774012543 domain linker motif; other site 1095774012544 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_11; cd06293 1095774012545 putative dimerization interface [polypeptide binding]; other site 1095774012546 putative ligand binding site [chemical binding]; other site 1095774012547 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1095774012548 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1095774012549 Walker A/P-loop; other site 1095774012550 ATP binding site [chemical binding]; other site 1095774012551 Q-loop/lid; other site 1095774012552 ABC transporter signature motif; other site 1095774012553 Walker B; other site 1095774012554 D-loop; other site 1095774012555 H-loop/switch region; other site 1095774012556 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1095774012557 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1095774012558 TM-ABC transporter signature motif; other site 1095774012559 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1095774012560 active site 1095774012561 substrate binding pocket [chemical binding]; other site 1095774012562 homodimer interaction site [polypeptide binding]; other site 1095774012563 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1095774012564 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1095774012565 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 1095774012566 metal binding site [ion binding]; metal-binding site 1095774012567 dimer interface [polypeptide binding]; other site 1095774012568 Src Homology 3 domain superfamily; Region: SH3; cl17036 1095774012569 Src Homology 3 domain superfamily; Region: SH3; cl17036 1095774012570 peptide ligand binding site [polypeptide binding]; other site 1095774012571 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1095774012572 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1095774012573 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1095774012574 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1095774012575 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1095774012576 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1095774012577 interface (dimer of trimers) [polypeptide binding]; other site 1095774012578 Substrate-binding/catalytic site; other site 1095774012579 Zn-binding sites [ion binding]; other site 1095774012580 DNA polymerase III subunit chi; Validated; Region: PRK05728 1095774012581 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1095774012582 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1095774012583 HIGH motif; other site 1095774012584 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1095774012585 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1095774012586 active site 1095774012587 KMSKS motif; other site 1095774012588 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1095774012589 tRNA binding surface [nucleotide binding]; other site 1095774012590 anticodon binding site; other site 1095774012591 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1095774012592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774012593 Coenzyme A binding pocket [chemical binding]; other site 1095774012594 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1095774012595 active site 1095774012596 dinuclear metal binding site [ion binding]; other site 1095774012597 dimerization interface [polypeptide binding]; other site 1095774012598 RNase E inhibitor protein; Provisional; Region: PRK11191 1095774012599 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1095774012600 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1095774012601 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1095774012602 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 1095774012603 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1095774012604 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1095774012605 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1095774012606 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1095774012607 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1095774012608 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1095774012609 homotrimer interaction site [polypeptide binding]; other site 1095774012610 putative active site [active] 1095774012611 Isochorismatase family; Region: Isochorismatase; pfam00857 1095774012612 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1095774012613 catalytic triad [active] 1095774012614 conserved cis-peptide bond; other site 1095774012615 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1095774012616 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1095774012617 conserved cys residue [active] 1095774012618 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774012619 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1095774012620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774012621 putative substrate translocation pore; other site 1095774012622 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1095774012623 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1095774012624 putative acyl-acceptor binding pocket; other site 1095774012625 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1095774012626 acyl-activating enzyme (AAE) consensus motif; other site 1095774012627 putative AMP binding site [chemical binding]; other site 1095774012628 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1095774012629 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1095774012630 Protein export membrane protein; Region: SecD_SecF; cl14618 1095774012631 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1095774012632 Protein export membrane protein; Region: SecD_SecF; cl14618 1095774012633 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1095774012634 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1095774012635 HlyD family secretion protein; Region: HlyD_3; pfam13437 1095774012636 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1095774012637 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1095774012638 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1095774012639 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1095774012640 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1095774012641 molybdopterin cofactor binding site [chemical binding]; other site 1095774012642 substrate binding site [chemical binding]; other site 1095774012643 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1095774012644 molybdopterin cofactor binding site; other site 1095774012645 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1095774012646 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774012647 DNA binding site [nucleotide binding] 1095774012648 domain linker motif; other site 1095774012649 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1095774012650 dimerization interface (closed form) [polypeptide binding]; other site 1095774012651 ligand binding site [chemical binding]; other site 1095774012652 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 1095774012653 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1095774012654 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1095774012655 active site 1095774012656 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1095774012657 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1095774012658 ATP cone domain; Region: ATP-cone; pfam03477 1095774012659 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1095774012660 effector binding site; other site 1095774012661 active site 1095774012662 Zn binding site [ion binding]; other site 1095774012663 glycine loop; other site 1095774012664 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1095774012665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1095774012666 FeS/SAM binding site; other site 1095774012667 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1095774012668 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1095774012669 NAD binding site [chemical binding]; other site 1095774012670 active site 1095774012671 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1095774012672 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1095774012673 proposed catalytic triad [active] 1095774012674 conserved cys residue [active] 1095774012675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897 1095774012676 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1095774012677 GIY-YIG motif/motif A; other site 1095774012678 putative active site [active] 1095774012679 putative metal binding site [ion binding]; other site 1095774012680 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774012681 Coenzyme A binding pocket [chemical binding]; other site 1095774012682 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1095774012683 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1095774012684 Peptidase family U32; Region: Peptidase_U32; pfam01136 1095774012685 putative protease; Provisional; Region: PRK15447 1095774012686 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1095774012687 hypothetical protein; Provisional; Region: PRK10508 1095774012688 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1095774012689 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1095774012690 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1095774012691 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1095774012692 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1095774012693 ATP binding site [chemical binding]; other site 1095774012694 Mg++ binding site [ion binding]; other site 1095774012695 motif III; other site 1095774012696 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1095774012697 nucleotide binding region [chemical binding]; other site 1095774012698 ATP-binding site [chemical binding]; other site 1095774012699 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1095774012700 putative RNA binding site [nucleotide binding]; other site 1095774012701 lipoprotein NlpI; Provisional; Region: PRK11189 1095774012702 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1095774012703 binding surface 1095774012704 TPR motif; other site 1095774012705 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1095774012706 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1095774012707 RNase E interface [polypeptide binding]; other site 1095774012708 trimer interface [polypeptide binding]; other site 1095774012709 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1095774012710 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1095774012711 RNase E interface [polypeptide binding]; other site 1095774012712 trimer interface [polypeptide binding]; other site 1095774012713 active site 1095774012714 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1095774012715 putative nucleic acid binding region [nucleotide binding]; other site 1095774012716 G-X-X-G motif; other site 1095774012717 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1095774012718 RNA binding site [nucleotide binding]; other site 1095774012719 domain interface; other site 1095774012720 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1095774012721 16S/18S rRNA binding site [nucleotide binding]; other site 1095774012722 S13e-L30e interaction site [polypeptide binding]; other site 1095774012723 25S rRNA binding site [nucleotide binding]; other site 1095774012724 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1095774012725 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1095774012726 RNA binding site [nucleotide binding]; other site 1095774012727 active site 1095774012728 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1095774012729 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1095774012730 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1095774012731 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1095774012732 translation initiation factor IF-2; Region: IF-2; TIGR00487 1095774012733 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1095774012734 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1095774012735 G1 box; other site 1095774012736 putative GEF interaction site [polypeptide binding]; other site 1095774012737 GTP/Mg2+ binding site [chemical binding]; other site 1095774012738 Switch I region; other site 1095774012739 G2 box; other site 1095774012740 G3 box; other site 1095774012741 Switch II region; other site 1095774012742 G4 box; other site 1095774012743 G5 box; other site 1095774012744 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1095774012745 Translation-initiation factor 2; Region: IF-2; pfam11987 1095774012746 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1095774012747 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1095774012748 NusA N-terminal domain; Region: NusA_N; pfam08529 1095774012749 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1095774012750 RNA binding site [nucleotide binding]; other site 1095774012751 homodimer interface [polypeptide binding]; other site 1095774012752 NusA-like KH domain; Region: KH_5; pfam13184 1095774012753 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1095774012754 G-X-X-G motif; other site 1095774012755 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1095774012756 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1095774012757 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1095774012758 Sm and related proteins; Region: Sm_like; cl00259 1095774012759 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1095774012760 putative oligomer interface [polypeptide binding]; other site 1095774012761 putative RNA binding site [nucleotide binding]; other site 1095774012762 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1095774012763 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1095774012764 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1095774012765 active site 1095774012766 substrate binding site [chemical binding]; other site 1095774012767 metal binding site [ion binding]; metal-binding site 1095774012768 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1095774012769 dihydropteroate synthase; Region: DHPS; TIGR01496 1095774012770 substrate binding pocket [chemical binding]; other site 1095774012771 dimer interface [polypeptide binding]; other site 1095774012772 inhibitor binding site; inhibition site 1095774012773 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1095774012774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1095774012775 Walker A motif; other site 1095774012776 ATP binding site [chemical binding]; other site 1095774012777 Walker B motif; other site 1095774012778 arginine finger; other site 1095774012779 Peptidase family M41; Region: Peptidase_M41; pfam01434 1095774012780 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1095774012781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774012782 S-adenosylmethionine binding site [chemical binding]; other site 1095774012783 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 1095774012784 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1095774012785 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1095774012786 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1095774012787 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1095774012788 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1095774012789 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1095774012790 CoenzymeA binding site [chemical binding]; other site 1095774012791 subunit interaction site [polypeptide binding]; other site 1095774012792 PHB binding site; other site 1095774012793 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1095774012794 GTP1/OBG; Region: GTP1_OBG; pfam01018 1095774012795 Obg GTPase; Region: Obg; cd01898 1095774012796 G1 box; other site 1095774012797 GTP/Mg2+ binding site [chemical binding]; other site 1095774012798 Switch I region; other site 1095774012799 G2 box; other site 1095774012800 G3 box; other site 1095774012801 Switch II region; other site 1095774012802 G4 box; other site 1095774012803 G5 box; other site 1095774012804 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1095774012805 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1095774012806 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1095774012807 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1095774012808 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1095774012809 substrate binding pocket [chemical binding]; other site 1095774012810 chain length determination region; other site 1095774012811 substrate-Mg2+ binding site; other site 1095774012812 catalytic residues [active] 1095774012813 aspartate-rich region 1; other site 1095774012814 active site lid residues [active] 1095774012815 aspartate-rich region 2; other site 1095774012816 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 1095774012817 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1095774012818 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1095774012819 hinge; other site 1095774012820 active site 1095774012821 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1095774012822 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1095774012823 anti sigma factor interaction site; other site 1095774012824 regulatory phosphorylation site [posttranslational modification]; other site 1095774012825 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1095774012826 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1095774012827 mce related protein; Region: MCE; pfam02470 1095774012828 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1095774012829 conserved hypothetical integral membrane protein; Region: TIGR00056 1095774012830 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1095774012831 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1095774012832 Walker A/P-loop; other site 1095774012833 ATP binding site [chemical binding]; other site 1095774012834 Q-loop/lid; other site 1095774012835 ABC transporter signature motif; other site 1095774012836 Walker B; other site 1095774012837 D-loop; other site 1095774012838 H-loop/switch region; other site 1095774012839 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1095774012840 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1095774012841 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1095774012842 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1095774012843 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1095774012844 putative active site [active] 1095774012845 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1095774012846 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1095774012847 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1095774012848 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1095774012849 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1095774012850 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 1095774012851 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1095774012852 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1095774012853 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1095774012854 Walker A/P-loop; other site 1095774012855 ATP binding site [chemical binding]; other site 1095774012856 Q-loop/lid; other site 1095774012857 ABC transporter signature motif; other site 1095774012858 Walker B; other site 1095774012859 D-loop; other site 1095774012860 H-loop/switch region; other site 1095774012861 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1095774012862 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1095774012863 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1095774012864 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1095774012865 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1095774012866 30S subunit binding site; other site 1095774012867 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1095774012868 active site 1095774012869 phosphorylation site [posttranslational modification] 1095774012870 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1095774012871 AAA domain; Region: AAA_18; pfam13238 1095774012872 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1095774012873 dimerization domain swap beta strand [polypeptide binding]; other site 1095774012874 regulatory protein interface [polypeptide binding]; other site 1095774012875 active site 1095774012876 regulatory phosphorylation site [posttranslational modification]; other site 1095774012877 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1095774012878 Transglycosylase; Region: Transgly; cl17702 1095774012879 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1095774012880 Remorin, C-terminal region; Region: Remorin_C; pfam03763 1095774012881 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1095774012882 putative active site [active] 1095774012883 heme pocket [chemical binding]; other site 1095774012884 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1095774012885 dimer interface [polypeptide binding]; other site 1095774012886 phosphorylation site [posttranslational modification] 1095774012887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774012888 ATP binding site [chemical binding]; other site 1095774012889 Mg2+ binding site [ion binding]; other site 1095774012890 G-X-G motif; other site 1095774012891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774012892 active site 1095774012893 phosphorylation site [posttranslational modification] 1095774012894 intermolecular recognition site; other site 1095774012895 dimerization interface [polypeptide binding]; other site 1095774012896 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1095774012897 putative binding surface; other site 1095774012898 active site 1095774012899 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 1095774012900 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1095774012901 active site 1095774012902 dimer interface [polypeptide binding]; other site 1095774012903 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1095774012904 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1095774012905 active site 1095774012906 FMN binding site [chemical binding]; other site 1095774012907 substrate binding site [chemical binding]; other site 1095774012908 3Fe-4S cluster binding site [ion binding]; other site 1095774012909 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 1095774012910 domain_subunit interface; other site 1095774012911 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1095774012912 Flavodoxin; Region: Flavodoxin_1; pfam00258 1095774012913 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1095774012914 FAD binding pocket [chemical binding]; other site 1095774012915 FAD binding motif [chemical binding]; other site 1095774012916 catalytic residues [active] 1095774012917 NAD binding pocket [chemical binding]; other site 1095774012918 phosphate binding motif [ion binding]; other site 1095774012919 beta-alpha-beta structure motif; other site 1095774012920 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1095774012921 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1095774012922 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1095774012923 C-terminal domain interface [polypeptide binding]; other site 1095774012924 putative GSH binding site (G-site) [chemical binding]; other site 1095774012925 dimer interface [polypeptide binding]; other site 1095774012926 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1095774012927 dimer interface [polypeptide binding]; other site 1095774012928 N-terminal domain interface [polypeptide binding]; other site 1095774012929 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1095774012930 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1095774012931 23S rRNA interface [nucleotide binding]; other site 1095774012932 L3 interface [polypeptide binding]; other site 1095774012933 Predicted ATPase [General function prediction only]; Region: COG1485 1095774012934 hypothetical protein; Provisional; Region: PRK11677 1095774012935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1095774012936 serine endoprotease; Provisional; Region: PRK10139 1095774012937 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1095774012938 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1095774012939 protein binding site [polypeptide binding]; other site 1095774012940 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1095774012941 protein binding site [polypeptide binding]; other site 1095774012942 serine endoprotease; Provisional; Region: PRK10898 1095774012943 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1095774012944 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1095774012945 protein binding site [polypeptide binding]; other site 1095774012946 poxB regulator PoxA; Provisional; Region: PRK09350 1095774012947 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1095774012948 motif 1; other site 1095774012949 dimer interface [polypeptide binding]; other site 1095774012950 active site 1095774012951 motif 2; other site 1095774012952 motif 3; other site 1095774012953 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1095774012954 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1095774012955 Predicted small secreted protein [Function unknown]; Region: COG5510 1095774012956 Entericidin EcnA/B family; Region: Entericidin; pfam08085 1095774012957 elongation factor P; Validated; Region: PRK00529 1095774012958 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1095774012959 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1095774012960 RNA binding site [nucleotide binding]; other site 1095774012961 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1095774012962 RNA binding site [nucleotide binding]; other site 1095774012963 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1095774012964 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1095774012965 FeS/SAM binding site; other site 1095774012966 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1095774012967 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1095774012968 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1095774012969 ring oligomerisation interface [polypeptide binding]; other site 1095774012970 ATP/Mg binding site [chemical binding]; other site 1095774012971 stacking interactions; other site 1095774012972 hinge regions; other site 1095774012973 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1095774012974 oligomerisation interface [polypeptide binding]; other site 1095774012975 mobile loop; other site 1095774012976 roof hairpin; other site 1095774012977 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1095774012978 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1095774012979 Aspartase; Region: Aspartase; cd01357 1095774012980 active sites [active] 1095774012981 tetramer interface [polypeptide binding]; other site 1095774012982 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1095774012983 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1095774012984 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 1095774012985 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1095774012986 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1095774012987 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1095774012988 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1095774012989 DsbD alpha interface [polypeptide binding]; other site 1095774012990 catalytic residues [active] 1095774012991 putative transcriptional regulator; Provisional; Region: PRK11640 1095774012992 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1095774012993 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1095774012994 active site 1095774012995 catalytic residues [active] 1095774012996 DNA binding site [nucleotide binding] 1095774012997 Int/Topo IB signature motif; other site 1095774012998 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1095774012999 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 1095774013000 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 1095774013001 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1095774013002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774013003 Coenzyme A binding pocket [chemical binding]; other site 1095774013004 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 1095774013005 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1095774013006 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1095774013007 YCII-related domain; Region: YCII; cl00999 1095774013008 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1095774013009 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1095774013010 active site 1095774013011 dimerization interface [polypeptide binding]; other site 1095774013012 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1095774013013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774013014 Walker A/P-loop; other site 1095774013015 ATP binding site [chemical binding]; other site 1095774013016 Q-loop/lid; other site 1095774013017 ABC transporter signature motif; other site 1095774013018 Walker B; other site 1095774013019 D-loop; other site 1095774013020 H-loop/switch region; other site 1095774013021 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1095774013022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774013023 dimer interface [polypeptide binding]; other site 1095774013024 conserved gate region; other site 1095774013025 putative PBP binding loops; other site 1095774013026 ABC-ATPase subunit interface; other site 1095774013027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774013028 dimer interface [polypeptide binding]; other site 1095774013029 conserved gate region; other site 1095774013030 putative PBP binding loops; other site 1095774013031 ABC-ATPase subunit interface; other site 1095774013032 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1095774013033 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1095774013034 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1095774013035 non-specific DNA interactions [nucleotide binding]; other site 1095774013036 DNA binding site [nucleotide binding] 1095774013037 sequence specific DNA binding site [nucleotide binding]; other site 1095774013038 putative cAMP binding site [chemical binding]; other site 1095774013039 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1095774013040 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1095774013041 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774013042 dimerization interface [polypeptide binding]; other site 1095774013043 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774013044 dimer interface [polypeptide binding]; other site 1095774013045 putative CheW interface [polypeptide binding]; other site 1095774013046 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440 1095774013047 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1095774013048 DNA binding site [nucleotide binding] 1095774013049 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1095774013050 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1095774013051 structural tetrad; other site 1095774013052 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1095774013053 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 1095774013054 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1095774013055 gating phenylalanine in ion channel; other site 1095774013056 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 1095774013057 ligand binding site [chemical binding]; other site 1095774013058 active site 1095774013059 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1095774013060 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1095774013061 DHHA2 domain; Region: DHHA2; pfam02833 1095774013062 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1095774013063 Ligand Binding Site [chemical binding]; other site 1095774013064 enolase; Provisional; Region: eno; PRK00077 1095774013065 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1095774013066 dimer interface [polypeptide binding]; other site 1095774013067 metal binding site [ion binding]; metal-binding site 1095774013068 substrate binding pocket [chemical binding]; other site 1095774013069 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1095774013070 catalytic core [active] 1095774013071 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1095774013072 chromosome condensation membrane protein; Provisional; Region: PRK14196 1095774013073 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1095774013074 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1095774013075 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1095774013076 active site 1095774013077 catalytic residues [active] 1095774013078 DNA binding site [nucleotide binding] 1095774013079 Int/Topo IB signature motif; other site 1095774013080 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1095774013081 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1095774013082 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1095774013083 active site 1095774013084 catalytic residues [active] 1095774013085 DNA binding site [nucleotide binding] 1095774013086 Int/Topo IB signature motif; other site 1095774013087 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1095774013088 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1095774013089 Catalytic site [active] 1095774013090 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1095774013091 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1095774013092 tetramer interface [polypeptide binding]; other site 1095774013093 active site 1095774013094 Mg2+/Mn2+ binding site [ion binding]; other site 1095774013095 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1095774013096 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 1095774013097 PYR/PP interface [polypeptide binding]; other site 1095774013098 dimer interface [polypeptide binding]; other site 1095774013099 TPP binding site [chemical binding]; other site 1095774013100 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1095774013101 TPP-binding site [chemical binding]; other site 1095774013102 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 1095774013103 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 1095774013104 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1095774013105 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1095774013106 active site 1095774013107 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1095774013108 dimer interface [polypeptide binding]; other site 1095774013109 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1095774013110 Ligand Binding Site [chemical binding]; other site 1095774013111 Molecular Tunnel; other site 1095774013112 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1095774013113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774013114 putative substrate translocation pore; other site 1095774013115 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 1095774013116 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1095774013117 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 1095774013118 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1095774013119 Protein of unknown function (DUF1281); Region: DUF1281; pfam06924 1095774013120 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 1095774013121 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 1095774013122 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 1095774013123 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1095774013124 Integrase; Region: Integrase_1; pfam12835 1095774013125 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1095774013126 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1095774013127 oligomer interface [polypeptide binding]; other site 1095774013128 active site residues [active] 1095774013129 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 1095774013130 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 1095774013131 PhoU domain; Region: PhoU; pfam01895 1095774013132 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 1095774013133 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 1095774013134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774013135 ATP binding site [chemical binding]; other site 1095774013136 Mg2+ binding site [ion binding]; other site 1095774013137 G-X-G motif; other site 1095774013138 AAA domain; Region: AAA_23; pfam13476 1095774013139 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1095774013140 ABC transporter signature motif; other site 1095774013141 Walker B; other site 1095774013142 D-loop; other site 1095774013143 H-loop/switch region; other site 1095774013144 Nucleotidyltransferase domain; Region: NTP_transf_2; pfam01909 1095774013145 metal binding triad [ion binding]; metal-binding site 1095774013146 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1095774013147 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 1095774013148 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 1095774013149 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 1095774013150 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1095774013151 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 1095774013152 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 1095774013153 conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750 1095774013154 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 1095774013155 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 1095774013156 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 1095774013157 integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747 1095774013158 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 1095774013159 conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754 1095774013160 Restriction endonuclease; Region: Mrr_cat; pfam04471 1095774013161 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 1095774013162 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 1095774013163 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 1095774013164 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1095774013165 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1095774013166 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1095774013167 catalytic residue [active] 1095774013168 PilS N terminal; Region: PilS; pfam08805 1095774013169 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1095774013170 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1095774013171 Type II/IV secretion system protein; Region: T2SE; pfam00437 1095774013172 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1095774013173 Walker A motif; other site 1095774013174 ATP binding site [chemical binding]; other site 1095774013175 Walker B motif; other site 1095774013176 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 1095774013177 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 1095774013178 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 1095774013179 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 1095774013180 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 1095774013181 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1095774013182 PilM; Region: PilM; pfam07419 1095774013183 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 1095774013184 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 1095774013185 Domain of unknown function DUF29; Region: DUF29; pfam01724 1095774013186 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1095774013187 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1095774013188 dimer interface [polypeptide binding]; other site 1095774013189 ssDNA binding site [nucleotide binding]; other site 1095774013190 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1095774013191 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 1095774013192 DNA topoisomerase III; Provisional; Region: PRK07726 1095774013193 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1095774013194 active site 1095774013195 putative interdomain interaction site [polypeptide binding]; other site 1095774013196 putative metal-binding site [ion binding]; other site 1095774013197 putative nucleotide binding site [chemical binding]; other site 1095774013198 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1095774013199 domain I; other site 1095774013200 DNA binding groove [nucleotide binding] 1095774013201 phosphate binding site [ion binding]; other site 1095774013202 domain II; other site 1095774013203 domain III; other site 1095774013204 nucleotide binding site [chemical binding]; other site 1095774013205 catalytic site [active] 1095774013206 domain IV; other site 1095774013207 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1095774013208 Domain of unknown function (DUF1845); Region: DUF1845; pfam08900 1095774013209 Helix-turn-helix domain; Region: HTH_36; pfam13730 1095774013210 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 1095774013211 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1095774013212 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1095774013213 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 1095774013214 ParB-like nuclease domain; Region: ParBc; pfam02195 1095774013215 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1095774013216 replicative DNA helicase; Region: DnaB; TIGR00665 1095774013217 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1095774013218 Walker A motif; other site 1095774013219 ATP binding site [chemical binding]; other site 1095774013220 Walker B motif; other site 1095774013221 DNA binding loops [nucleotide binding] 1095774013222 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1095774013223 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1095774013224 P-loop; other site 1095774013225 Magnesium ion binding site [ion binding]; other site 1095774013226 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1095774013227 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1095774013228 active site 1095774013229 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1095774013230 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1095774013231 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1095774013232 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1095774013233 active site 1095774013234 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1095774013235 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1095774013236 G1 box; other site 1095774013237 GTP/Mg2+ binding site [chemical binding]; other site 1095774013238 Switch I region; other site 1095774013239 G2 box; other site 1095774013240 G3 box; other site 1095774013241 Switch II region; other site 1095774013242 G4 box; other site 1095774013243 G5 box; other site 1095774013244 Nucleoside recognition; Region: Gate; pfam07670 1095774013245 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1095774013246 Nucleoside recognition; Region: Gate; pfam07670 1095774013247 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 1095774013248 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1095774013249 DNA-binding site [nucleotide binding]; DNA binding site 1095774013250 RNA-binding motif; other site 1095774013251 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1095774013252 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1095774013253 dimer interface [polypeptide binding]; other site 1095774013254 ligand binding site [chemical binding]; other site 1095774013255 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774013256 dimerization interface [polypeptide binding]; other site 1095774013257 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774013258 dimer interface [polypeptide binding]; other site 1095774013259 putative CheW interface [polypeptide binding]; other site 1095774013260 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1095774013261 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1095774013262 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1095774013263 active site 1095774013264 catalytic tetrad [active] 1095774013265 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 1095774013266 Cupin domain; Region: Cupin_2; cl17218 1095774013267 AAA domain; Region: AAA_17; pfam13207 1095774013268 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1095774013269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774013270 Coenzyme A binding pocket [chemical binding]; other site 1095774013271 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1095774013272 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1095774013273 Bacterial transcriptional regulator; Region: IclR; pfam01614 1095774013274 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1095774013275 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1095774013276 Walker A/P-loop; other site 1095774013277 ATP binding site [chemical binding]; other site 1095774013278 Q-loop/lid; other site 1095774013279 ABC transporter signature motif; other site 1095774013280 Walker B; other site 1095774013281 D-loop; other site 1095774013282 H-loop/switch region; other site 1095774013283 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1095774013284 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1095774013285 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1095774013286 TM-ABC transporter signature motif; other site 1095774013287 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315 1095774013288 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1095774013289 putative ligand binding site [chemical binding]; other site 1095774013290 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1095774013291 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 1095774013292 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1095774013293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774013294 D-galactonate transporter; Region: 2A0114; TIGR00893 1095774013295 putative substrate translocation pore; other site 1095774013296 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1095774013297 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1095774013298 putative N- and C-terminal domain interface [polypeptide binding]; other site 1095774013299 putative active site [active] 1095774013300 MgATP binding site [chemical binding]; other site 1095774013301 catalytic site [active] 1095774013302 metal binding site [ion binding]; metal-binding site 1095774013303 putative xylulose binding site [chemical binding]; other site 1095774013304 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1095774013305 active site 1095774013306 magnesium binding site [ion binding]; other site 1095774013307 dimer interface [polypeptide binding]; other site 1095774013308 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1095774013309 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1095774013310 AP (apurinic/apyrimidinic) site pocket; other site 1095774013311 DNA interaction; other site 1095774013312 Metal-binding active site; metal-binding site 1095774013313 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1095774013314 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1095774013315 intersubunit interface [polypeptide binding]; other site 1095774013316 active site 1095774013317 Zn2+ binding site [ion binding]; other site 1095774013318 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 1095774013319 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1095774013320 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1095774013321 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1095774013322 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774013323 dimer interface [polypeptide binding]; other site 1095774013324 putative CheW interface [polypeptide binding]; other site 1095774013325 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1095774013326 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1095774013327 N-terminal plug; other site 1095774013328 ligand-binding site [chemical binding]; other site 1095774013329 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1095774013330 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1095774013331 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1095774013332 IucA / IucC family; Region: IucA_IucC; pfam04183 1095774013333 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1095774013334 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1095774013335 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1095774013336 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1095774013337 IucA / IucC family; Region: IucA_IucC; pfam04183 1095774013338 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1095774013339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774013340 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1095774013341 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1095774013342 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1095774013343 FAD binding pocket [chemical binding]; other site 1095774013344 FAD binding motif [chemical binding]; other site 1095774013345 phosphate binding motif [ion binding]; other site 1095774013346 NAD binding pocket [chemical binding]; other site 1095774013347 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 1095774013348 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774013349 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774013350 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1095774013351 dimerization interface [polypeptide binding]; other site 1095774013352 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1095774013353 DsrE/DsrF-like family; Region: DrsE; cl00672 1095774013354 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1095774013355 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1095774013356 Putative phosphatase (DUF442); Region: DUF442; cl17385 1095774013357 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1095774013358 Predicted transporter component [General function prediction only]; Region: COG2391 1095774013359 Predicted transporter component [General function prediction only]; Region: COG2391 1095774013360 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1095774013361 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1095774013362 dimerization domain [polypeptide binding]; other site 1095774013363 dimer interface [polypeptide binding]; other site 1095774013364 catalytic residues [active] 1095774013365 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 1095774013366 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1095774013367 DNA binding site [nucleotide binding] 1095774013368 domain linker motif; other site 1095774013369 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1095774013370 dimerization interface [polypeptide binding]; other site 1095774013371 ligand binding site [chemical binding]; other site 1095774013372 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1095774013373 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1095774013374 substrate binding [chemical binding]; other site 1095774013375 active site 1095774013376 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1095774013377 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1095774013378 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1095774013379 active site turn [active] 1095774013380 phosphorylation site [posttranslational modification] 1095774013381 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1095774013382 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1095774013383 trimer interface; other site 1095774013384 sugar binding site [chemical binding]; other site 1095774013385 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 1095774013386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774013387 putative substrate translocation pore; other site 1095774013388 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1095774013389 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1095774013390 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1095774013391 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1095774013392 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1095774013393 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1095774013394 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1095774013395 putative substrate binding site [chemical binding]; other site 1095774013396 putative ATP binding site [chemical binding]; other site 1095774013397 putative S-transferase; Provisional; Region: PRK11752 1095774013398 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1095774013399 C-terminal domain interface [polypeptide binding]; other site 1095774013400 GSH binding site (G-site) [chemical binding]; other site 1095774013401 dimer interface [polypeptide binding]; other site 1095774013402 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1095774013403 N-terminal domain interface [polypeptide binding]; other site 1095774013404 dimer interface [polypeptide binding]; other site 1095774013405 substrate binding pocket (H-site) [chemical binding]; other site 1095774013406 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 1095774013407 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1095774013408 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774013409 dimer interface [polypeptide binding]; other site 1095774013410 putative CheW interface [polypeptide binding]; other site 1095774013411 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774013412 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1095774013413 dimerization interface [polypeptide binding]; other site 1095774013414 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1095774013415 tartrate dehydrogenase; Region: TTC; TIGR02089 1095774013416 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1095774013417 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1095774013418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774013419 dimer interface [polypeptide binding]; other site 1095774013420 conserved gate region; other site 1095774013421 putative PBP binding loops; other site 1095774013422 ABC-ATPase subunit interface; other site 1095774013423 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1095774013424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774013425 dimer interface [polypeptide binding]; other site 1095774013426 conserved gate region; other site 1095774013427 putative PBP binding loops; other site 1095774013428 ABC-ATPase subunit interface; other site 1095774013429 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1095774013430 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1095774013431 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1095774013432 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1095774013433 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1095774013434 Walker A/P-loop; other site 1095774013435 ATP binding site [chemical binding]; other site 1095774013436 Q-loop/lid; other site 1095774013437 ABC transporter signature motif; other site 1095774013438 Walker B; other site 1095774013439 D-loop; other site 1095774013440 H-loop/switch region; other site 1095774013441 TOBE domain; Region: TOBE_2; pfam08402 1095774013442 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1095774013443 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1095774013444 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1095774013445 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 1095774013446 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1095774013447 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1095774013448 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1095774013449 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1095774013450 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1095774013451 Trp docking motif [polypeptide binding]; other site 1095774013452 putative active site [active] 1095774013453 drug efflux system protein MdtG; Provisional; Region: PRK09874 1095774013454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774013455 putative substrate translocation pore; other site 1095774013456 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774013457 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774013458 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1095774013459 putative effector binding pocket; other site 1095774013460 dimerization interface [polypeptide binding]; other site 1095774013461 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1095774013462 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774013463 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774013464 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1095774013465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1095774013466 active site 1095774013467 phosphorylation site [posttranslational modification] 1095774013468 intermolecular recognition site; other site 1095774013469 dimerization interface [polypeptide binding]; other site 1095774013470 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1095774013471 DNA binding site [nucleotide binding] 1095774013472 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1095774013473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1095774013474 dimer interface [polypeptide binding]; other site 1095774013475 phosphorylation site [posttranslational modification] 1095774013476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1095774013477 ATP binding site [chemical binding]; other site 1095774013478 Mg2+ binding site [ion binding]; other site 1095774013479 G-X-G motif; other site 1095774013480 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1095774013481 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1095774013482 dimer interface [polypeptide binding]; other site 1095774013483 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1095774013484 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1095774013485 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1095774013486 dimerization interface [polypeptide binding]; other site 1095774013487 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774013488 dimer interface [polypeptide binding]; other site 1095774013489 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1095774013490 putative CheW interface [polypeptide binding]; other site 1095774013491 benzoate transport; Region: 2A0115; TIGR00895 1095774013492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774013493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774013494 Cytochrome c; Region: Cytochrom_C; pfam00034 1095774013495 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1095774013496 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1095774013497 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1095774013498 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1095774013499 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1095774013500 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1095774013501 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1095774013502 microcin B17 transporter; Reviewed; Region: PRK11098 1095774013503 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1095774013504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774013505 putative substrate translocation pore; other site 1095774013506 Cupin; Region: Cupin_6; pfam12852 1095774013507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774013508 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1095774013509 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774013510 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1095774013511 PAS domain; Region: PAS_9; pfam13426 1095774013512 putative active site [active] 1095774013513 heme pocket [chemical binding]; other site 1095774013514 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1095774013515 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1095774013516 dimer interface [polypeptide binding]; other site 1095774013517 putative CheW interface [polypeptide binding]; other site 1095774013518 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1095774013519 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1095774013520 active site turn [active] 1095774013521 phosphorylation site [posttranslational modification] 1095774013522 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1095774013523 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1095774013524 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1095774013525 putative active site [active] 1095774013526 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1095774013527 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1095774013528 acetyl-CoA synthetase; Provisional; Region: PRK00174 1095774013529 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1095774013530 active site 1095774013531 CoA binding site [chemical binding]; other site 1095774013532 acyl-activating enzyme (AAE) consensus motif; other site 1095774013533 AMP binding site [chemical binding]; other site 1095774013534 acetate binding site [chemical binding]; other site 1095774013535 Predicted membrane protein [Function unknown]; Region: COG3162 1095774013536 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1095774013537 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1095774013538 Na binding site [ion binding]; other site 1095774013539 YfaZ precursor; Region: YfaZ; pfam07437 1095774013540 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 1095774013541 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1095774013542 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1095774013543 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1095774013544 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774013545 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1095774013546 putative dimerization interface [polypeptide binding]; other site 1095774013547 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1095774013548 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1095774013549 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1095774013550 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1095774013551 putative C-terminal domain interface [polypeptide binding]; other site 1095774013552 putative GSH binding site (G-site) [chemical binding]; other site 1095774013553 putative dimer interface [polypeptide binding]; other site 1095774013554 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1095774013555 putative N-terminal domain interface [polypeptide binding]; other site 1095774013556 putative dimer interface [polypeptide binding]; other site 1095774013557 putative substrate binding pocket (H-site) [chemical binding]; other site 1095774013558 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 1095774013559 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1095774013560 DNA binding residues [nucleotide binding] 1095774013561 dimer interface [polypeptide binding]; other site 1095774013562 [2Fe-2S] cluster binding site [ion binding]; other site 1095774013563 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1095774013564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774013565 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 1095774013566 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1095774013567 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1095774013568 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1095774013569 DNA-binding interface [nucleotide binding]; DNA binding site 1095774013570 Winged helix-turn helix; Region: HTH_29; pfam13551 1095774013571 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1095774013572 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1095774013573 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1095774013574 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1095774013575 catalytic triad [active] 1095774013576 conserved cis-peptide bond; other site 1095774013577 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 1095774013578 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1095774013579 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1095774013580 dimer interface [polypeptide binding]; other site 1095774013581 ssDNA binding site [nucleotide binding]; other site 1095774013582 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1095774013583 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1095774013584 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1095774013585 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1095774013586 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1095774013587 TIGR04076 family protein; Region: TIGR04076 1095774013588 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1095774013589 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1095774013590 putative NAD(P) binding site [chemical binding]; other site 1095774013591 putative substrate binding site [chemical binding]; other site 1095774013592 catalytic Zn binding site [ion binding]; other site 1095774013593 structural Zn binding site [ion binding]; other site 1095774013594 dimer interface [polypeptide binding]; other site 1095774013595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1095774013596 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1095774013597 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1095774013598 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1095774013599 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774013600 homodimer interface [polypeptide binding]; other site 1095774013601 catalytic residue [active] 1095774013602 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1095774013603 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1095774013604 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1095774013605 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1095774013606 putative DNA binding site [nucleotide binding]; other site 1095774013607 putative Zn2+ binding site [ion binding]; other site 1095774013608 AsnC family; Region: AsnC_trans_reg; pfam01037 1095774013609 replicative DNA helicase; Provisional; Region: PRK08006 1095774013610 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1095774013611 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1095774013612 Walker A motif; other site 1095774013613 ATP binding site [chemical binding]; other site 1095774013614 Walker B motif; other site 1095774013615 DNA binding loops [nucleotide binding] 1095774013616 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1095774013617 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1095774013618 NADP binding site [chemical binding]; other site 1095774013619 dimer interface [polypeptide binding]; other site 1095774013620 phage shock protein G; Reviewed; Region: pspG; PRK09459 1095774013621 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1095774013622 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1095774013623 FMN binding site [chemical binding]; other site 1095774013624 active site 1095774013625 catalytic residues [active] 1095774013626 substrate binding site [chemical binding]; other site 1095774013627 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 1095774013628 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1095774013629 metal binding site 2 [ion binding]; metal-binding site 1095774013630 putative DNA binding helix; other site 1095774013631 metal binding site 1 [ion binding]; metal-binding site 1095774013632 dimer interface [polypeptide binding]; other site 1095774013633 structural Zn2+ binding site [ion binding]; other site 1095774013634 hypothetical protein; Provisional; Region: PRK10428 1095774013635 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1095774013636 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1095774013637 LexA repressor; Validated; Region: PRK00215 1095774013638 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1095774013639 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1095774013640 Catalytic site [active] 1095774013641 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1095774013642 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1095774013643 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1095774013644 putative acyl-acceptor binding pocket; other site 1095774013645 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1095774013646 UbiA prenyltransferase family; Region: UbiA; pfam01040 1095774013647 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1095774013648 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1095774013649 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 1095774013650 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1095774013651 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1095774013652 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1095774013653 Sodium Bile acid symporter family; Region: SBF; pfam01758 1095774013654 aspartate kinase III; Validated; Region: PRK09084 1095774013655 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1095774013656 nucleotide binding site [chemical binding]; other site 1095774013657 substrate binding site [chemical binding]; other site 1095774013658 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1095774013659 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1095774013660 dimer interface [polypeptide binding]; other site 1095774013661 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1095774013662 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1095774013663 active site 1095774013664 dimer interface [polypeptide binding]; other site 1095774013665 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1095774013666 dimer interface [polypeptide binding]; other site 1095774013667 active site 1095774013668 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1095774013669 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1095774013670 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1095774013671 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1095774013672 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1095774013673 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1095774013674 substrate binding pocket [chemical binding]; other site 1095774013675 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1095774013676 B12 binding site [chemical binding]; other site 1095774013677 cobalt ligand [ion binding]; other site 1095774013678 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1095774013679 transcriptional repressor IclR; Provisional; Region: PRK11569 1095774013680 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1095774013681 Bacterial transcriptional regulator; Region: IclR; pfam01614 1095774013682 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1095774013683 Beta-lactamase; Region: Beta-lactamase; pfam00144 1095774013684 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1095774013685 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1095774013686 putative outer membrane porin protein; Provisional; Region: PRK11379 1095774013687 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 1095774013688 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774013689 DNA-binding site [nucleotide binding]; DNA binding site 1095774013690 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1095774013691 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1095774013692 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1095774013693 isocitrate lyase; Provisional; Region: PRK15063 1095774013694 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1095774013695 tetramer interface [polypeptide binding]; other site 1095774013696 active site 1095774013697 Mg2+/Mn2+ binding site [ion binding]; other site 1095774013698 malate synthase A; Region: malate_syn_A; TIGR01344 1095774013699 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1095774013700 active site 1095774013701 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1095774013702 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1095774013703 proposed active site lysine [active] 1095774013704 conserved cys residue [active] 1095774013705 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1095774013706 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1095774013707 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1095774013708 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1095774013709 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1095774013710 putative ligand binding residues [chemical binding]; other site 1095774013711 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1095774013712 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1095774013713 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1095774013714 purine monophosphate binding site [chemical binding]; other site 1095774013715 dimer interface [polypeptide binding]; other site 1095774013716 putative catalytic residues [active] 1095774013717 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1095774013718 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1095774013719 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1095774013720 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1095774013721 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1095774013722 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1095774013723 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1095774013724 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1095774013725 IHF dimer interface [polypeptide binding]; other site 1095774013726 IHF - DNA interface [nucleotide binding]; other site 1095774013727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1095774013728 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1095774013729 Active_site [active] 1095774013730 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1095774013731 substrate binding site [chemical binding]; other site 1095774013732 active site 1095774013733 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1095774013734 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1095774013735 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1095774013736 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1095774013737 putative NADH binding site [chemical binding]; other site 1095774013738 putative active site [active] 1095774013739 nudix motif; other site 1095774013740 putative metal binding site [ion binding]; other site 1095774013741 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 1095774013742 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1095774013743 ThiC-associated domain; Region: ThiC-associated; pfam13667 1095774013744 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1095774013745 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1095774013746 thiamine phosphate binding site [chemical binding]; other site 1095774013747 active site 1095774013748 pyrophosphate binding site [ion binding]; other site 1095774013749 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1095774013750 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1095774013751 DNA-binding site [nucleotide binding]; DNA binding site 1095774013752 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1095774013753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774013754 homodimer interface [polypeptide binding]; other site 1095774013755 catalytic residue [active] 1095774013756 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 1095774013757 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1095774013758 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1095774013759 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1095774013760 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1095774013761 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1095774013762 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1095774013763 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1095774013764 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1095774013765 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1095774013766 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1095774013767 DNA binding site [nucleotide binding] 1095774013768 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1095774013769 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1095774013770 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1095774013771 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1095774013772 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1095774013773 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1095774013774 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1095774013775 RPB3 interaction site [polypeptide binding]; other site 1095774013776 RPB1 interaction site [polypeptide binding]; other site 1095774013777 RPB11 interaction site [polypeptide binding]; other site 1095774013778 RPB10 interaction site [polypeptide binding]; other site 1095774013779 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1095774013780 L11 interface [polypeptide binding]; other site 1095774013781 putative EF-Tu interaction site [polypeptide binding]; other site 1095774013782 putative EF-G interaction site [polypeptide binding]; other site 1095774013783 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1095774013784 23S rRNA interface [nucleotide binding]; other site 1095774013785 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1095774013786 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1095774013787 mRNA/rRNA interface [nucleotide binding]; other site 1095774013788 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1095774013789 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1095774013790 23S rRNA interface [nucleotide binding]; other site 1095774013791 L7/L12 interface [polypeptide binding]; other site 1095774013792 putative thiostrepton binding site; other site 1095774013793 L25 interface [polypeptide binding]; other site 1095774013794 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1095774013795 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1095774013796 putative homodimer interface [polypeptide binding]; other site 1095774013797 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1095774013798 heterodimer interface [polypeptide binding]; other site 1095774013799 homodimer interface [polypeptide binding]; other site 1095774013800 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1095774013801 elongation factor Tu; Reviewed; Region: PRK00049 1095774013802 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1095774013803 G1 box; other site 1095774013804 GEF interaction site [polypeptide binding]; other site 1095774013805 GTP/Mg2+ binding site [chemical binding]; other site 1095774013806 Switch I region; other site 1095774013807 G2 box; other site 1095774013808 G3 box; other site 1095774013809 Switch II region; other site 1095774013810 G4 box; other site 1095774013811 G5 box; other site 1095774013812 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1095774013813 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1095774013814 Antibiotic Binding Site [chemical binding]; other site 1095774013815 pantothenate kinase; Provisional; Region: PRK05439 1095774013816 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1095774013817 ATP-binding site [chemical binding]; other site 1095774013818 CoA-binding site [chemical binding]; other site 1095774013819 Mg2+-binding site [ion binding]; other site 1095774013820 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1095774013821 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1095774013822 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1095774013823 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1095774013824 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1095774013825 FAD binding domain; Region: FAD_binding_4; pfam01565 1095774013826 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1095774013827 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 1095774013828 potassium transporter; Provisional; Region: PRK10750 1095774013829 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1095774013830 hypothetical protein; Provisional; Region: PRK11568 1095774013831 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1095774013832 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1095774013833 proline dipeptidase; Provisional; Region: PRK13607 1095774013834 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1095774013835 active site 1095774013836 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1095774013837 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1095774013838 substrate binding site [chemical binding]; other site 1095774013839 oxyanion hole (OAH) forming residues; other site 1095774013840 trimer interface [polypeptide binding]; other site 1095774013841 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1095774013842 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1095774013843 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1095774013844 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1095774013845 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1095774013846 dimer interface [polypeptide binding]; other site 1095774013847 active site 1095774013848 FMN reductase; Validated; Region: fre; PRK08051 1095774013849 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1095774013850 FAD binding pocket [chemical binding]; other site 1095774013851 FAD binding motif [chemical binding]; other site 1095774013852 phosphate binding motif [ion binding]; other site 1095774013853 beta-alpha-beta structure motif; other site 1095774013854 NAD binding pocket [chemical binding]; other site 1095774013855 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1095774013856 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1095774013857 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1095774013858 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1095774013859 active site 1095774013860 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1095774013861 sec-independent translocase; Provisional; Region: PRK01770 1095774013862 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1095774013863 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1095774013864 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1095774013865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1095774013866 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1095774013867 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1095774013868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1095774013869 S-adenosylmethionine binding site [chemical binding]; other site 1095774013870 DNA recombination protein RmuC; Provisional; Region: PRK10361 1095774013871 RmuC family; Region: RmuC; pfam02646 1095774013872 uridine phosphorylase; Provisional; Region: PRK11178 1095774013873 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1095774013874 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1095774013875 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1095774013876 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1095774013877 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1095774013878 THF binding site; other site 1095774013879 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1095774013880 substrate binding site [chemical binding]; other site 1095774013881 THF binding site; other site 1095774013882 zinc-binding site [ion binding]; other site 1095774013883 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1095774013884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1095774013885 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1095774013886 putative dimerization interface [polypeptide binding]; other site 1095774013887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1095774013888 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1095774013889 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1095774013890 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1095774013891 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1095774013892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1095774013893 putative substrate translocation pore; other site 1095774013894 putative hydrolase; Provisional; Region: PRK10976 1095774013895 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774013896 active site 1095774013897 motif I; other site 1095774013898 motif II; other site 1095774013899 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774013900 lysophospholipase L2; Provisional; Region: PRK10749 1095774013901 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1095774013902 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 1095774013903 threonine efflux system; Provisional; Region: PRK10229 1095774013904 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1095774013905 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1095774013906 ATP binding site [chemical binding]; other site 1095774013907 putative Mg++ binding site [ion binding]; other site 1095774013908 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1095774013909 nucleotide binding region [chemical binding]; other site 1095774013910 ATP-binding site [chemical binding]; other site 1095774013911 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1095774013912 HRDC domain; Region: HRDC; pfam00570 1095774013913 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1095774013914 dimerization interface [polypeptide binding]; other site 1095774013915 substrate binding site [chemical binding]; other site 1095774013916 active site 1095774013917 calcium binding site [ion binding]; other site 1095774013918 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1095774013919 CoenzymeA binding site [chemical binding]; other site 1095774013920 subunit interaction site [polypeptide binding]; other site 1095774013921 PHB binding site; other site 1095774013922 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1095774013923 Predicted transcriptional regulators [Transcription]; Region: COG1733 1095774013924 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1095774013925 dimerization interface [polypeptide binding]; other site 1095774013926 putative DNA binding site [nucleotide binding]; other site 1095774013927 putative Zn2+ binding site [ion binding]; other site 1095774013928 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1095774013929 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1095774013930 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1095774013931 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1095774013932 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1095774013933 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1095774013934 Cl binding site [ion binding]; other site 1095774013935 oligomer interface [polypeptide binding]; other site 1095774013936 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1095774013937 Part of AAA domain; Region: AAA_19; pfam13245 1095774013938 Family description; Region: UvrD_C_2; pfam13538 1095774013939 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1095774013940 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774013941 motif II; other site 1095774013942 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1095774013943 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1095774013944 active site 1095774013945 DNA binding site [nucleotide binding] 1095774013946 Int/Topo IB signature motif; other site 1095774013947 hypothetical protein; Provisional; Region: PRK10963 1095774013948 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1095774013949 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1095774013950 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1095774013951 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 1095774013952 adenylate cyclase; Provisional; Region: cyaA; PRK09450 1095774013953 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1095774013954 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1095774013955 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1095774013956 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1095774013957 domain interfaces; other site 1095774013958 active site 1095774013959 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1095774013960 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1095774013961 active site 1095774013962 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1095774013963 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 1095774013964 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1095774013965 HemY protein N-terminus; Region: HemY_N; pfam07219 1095774013966 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1095774013967 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1095774013968 putative common antigen polymerase; Provisional; Region: PRK02975 1095774013969 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929 1095774013970 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1095774013971 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1095774013972 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1095774013973 inhibitor-cofactor binding pocket; inhibition site 1095774013974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1095774013975 catalytic residue [active] 1095774013976 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1095774013977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1095774013978 Coenzyme A binding pocket [chemical binding]; other site 1095774013979 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1095774013980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1095774013981 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1095774013982 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1095774013983 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1095774013984 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1095774013985 active site 1095774013986 homodimer interface [polypeptide binding]; other site 1095774013987 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1095774013988 Chain length determinant protein; Region: Wzz; pfam02706 1095774013989 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1095774013990 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1095774013991 Mg++ binding site [ion binding]; other site 1095774013992 putative catalytic motif [active] 1095774013993 substrate binding site [chemical binding]; other site 1095774013994 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1095774013995 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1095774013996 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1095774013997 RNA binding site [nucleotide binding]; other site 1095774013998 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1095774013999 multimer interface [polypeptide binding]; other site 1095774014000 Walker A motif; other site 1095774014001 ATP binding site [chemical binding]; other site 1095774014002 Walker B motif; other site 1095774014003 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1095774014004 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1095774014005 catalytic residues [active] 1095774014006 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1095774014007 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1095774014008 ATP binding site [chemical binding]; other site 1095774014009 Mg++ binding site [ion binding]; other site 1095774014010 motif III; other site 1095774014011 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1095774014012 nucleotide binding region [chemical binding]; other site 1095774014013 ATP-binding site [chemical binding]; other site 1095774014014 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1095774014015 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1095774014016 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1095774014017 Part of AAA domain; Region: AAA_19; pfam13245 1095774014018 Family description; Region: UvrD_C_2; pfam13538 1095774014019 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1095774014020 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1095774014021 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1095774014022 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1095774014023 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1095774014024 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1095774014025 substrate binding site [chemical binding]; other site 1095774014026 ATP binding site [chemical binding]; other site 1095774014027 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1095774014028 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1095774014029 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1095774014030 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1095774014031 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1095774014032 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1095774014033 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1095774014034 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1095774014035 putative diguanylate cyclase; Provisional; Region: PRK13561 1095774014036 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1095774014037 metal binding site [ion binding]; metal-binding site 1095774014038 active site 1095774014039 I-site; other site 1095774014040 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1095774014041 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1095774014042 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 1095774014043 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1095774014044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1095774014045 binding surface 1095774014046 TPR motif; other site 1095774014047 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1095774014048 cellulose synthase regulator protein; Provisional; Region: PRK11114 1095774014049 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 1095774014050 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1095774014051 DXD motif; other site 1095774014052 PilZ domain; Region: PilZ; pfam07238 1095774014053 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 1095774014054 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1095774014055 P-loop; other site 1095774014056 Magnesium ion binding site [ion binding]; other site 1095774014057 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1095774014058 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1095774014059 Walker A/P-loop; other site 1095774014060 ATP binding site [chemical binding]; other site 1095774014061 Q-loop/lid; other site 1095774014062 ABC transporter signature motif; other site 1095774014063 Walker B; other site 1095774014064 D-loop; other site 1095774014065 H-loop/switch region; other site 1095774014066 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1095774014067 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1095774014068 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1095774014069 Walker A/P-loop; other site 1095774014070 ATP binding site [chemical binding]; other site 1095774014071 Q-loop/lid; other site 1095774014072 ABC transporter signature motif; other site 1095774014073 Walker B; other site 1095774014074 D-loop; other site 1095774014075 H-loop/switch region; other site 1095774014076 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1095774014077 dipeptide transporter; Provisional; Region: PRK10913 1095774014078 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1095774014079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774014080 dimer interface [polypeptide binding]; other site 1095774014081 conserved gate region; other site 1095774014082 putative PBP binding loops; other site 1095774014083 ABC-ATPase subunit interface; other site 1095774014084 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1095774014085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1095774014086 dimer interface [polypeptide binding]; other site 1095774014087 conserved gate region; other site 1095774014088 putative PBP binding loops; other site 1095774014089 ABC-ATPase subunit interface; other site 1095774014090 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1095774014091 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1095774014092 peptide binding site [polypeptide binding]; other site 1095774014093 phosphoethanolamine transferase; Provisional; Region: PRK11560 1095774014094 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1095774014095 Sulfatase; Region: Sulfatase; pfam00884 1095774014096 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1095774014097 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1095774014098 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1095774014099 putative Zn2+ binding site [ion binding]; other site 1095774014100 putative DNA binding site [nucleotide binding]; other site 1095774014101 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1095774014102 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1095774014103 Zn2+ binding site [ion binding]; other site 1095774014104 Mg2+ binding site [ion binding]; other site 1095774014105 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 1095774014106 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1095774014107 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1095774014108 catalytic residue [active] 1095774014109 tryptophan permease TnaB; Provisional; Region: PRK09664 1095774014110 aromatic amino acid transport protein; Region: araaP; TIGR00837 1095774014111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1095774014112 non-specific DNA binding site [nucleotide binding]; other site 1095774014113 salt bridge; other site 1095774014114 sequence-specific DNA binding site [nucleotide binding]; other site 1095774014115 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1095774014116 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1095774014117 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1095774014118 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1095774014119 active site 1095774014120 P-loop; other site 1095774014121 phosphorylation site [posttranslational modification] 1095774014122 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1095774014123 active site 1095774014124 phosphorylation site [posttranslational modification] 1095774014125 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1095774014126 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1095774014127 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1095774014128 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1095774014129 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 1095774014130 hypothetical protein; Provisional; Region: PRK11020 1095774014131 Protein of unknown function (DUF535); Region: DUF535; pfam04393 1095774014132 superoxide dismutase; Provisional; Region: PRK10925 1095774014133 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1095774014134 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1095774014135 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1095774014136 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1095774014137 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1095774014138 putative glutathione S-transferase; Provisional; Region: PRK10357 1095774014139 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1095774014140 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1095774014141 dimer interface [polypeptide binding]; other site 1095774014142 N-terminal domain interface [polypeptide binding]; other site 1095774014143 putative substrate binding pocket (H-site) [chemical binding]; other site 1095774014144 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1095774014145 MltA-interacting protein MipA; Region: MipA; cl01504 1095774014146 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1095774014147 DALR anticodon binding domain; Region: DALR_1; pfam05746 1095774014148 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1095774014149 dimer interface [polypeptide binding]; other site 1095774014150 motif 1; other site 1095774014151 active site 1095774014152 motif 2; other site 1095774014153 motif 3; other site 1095774014154 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1095774014155 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1095774014156 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1095774014157 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1095774014158 active site 1095774014159 motif I; other site 1095774014160 motif II; other site 1095774014161 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1095774014162 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1095774014163 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1095774014164 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1095774014165 putative FMN binding site [chemical binding]; other site 1095774014166 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1095774014167 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1095774014168 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1095774014169 G1 box; other site 1095774014170 GTP/Mg2+ binding site [chemical binding]; other site 1095774014171 Switch I region; other site 1095774014172 G2 box; other site 1095774014173 Switch II region; other site 1095774014174 G3 box; other site 1095774014175 G4 box; other site 1095774014176 G5 box; other site 1095774014177 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1095774014178 membrane protein insertase; Provisional; Region: PRK01318 1095774014179 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1095774014180 hypothetical protein; Validated; Region: PRK00041 1095774014181 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1095774014182 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399