-- dump date   	20140619_231748
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1075089000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1075089000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1075089000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1075089000004	Walker A motif; other site
1075089000005	ATP binding site [chemical binding]; other site
1075089000006	Walker B motif; other site
1075089000007	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1075089000008	arginine finger; other site
1075089000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1075089000010	DnaA box-binding interface [nucleotide binding]; other site
1075089000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
1075089000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1075089000013	putative DNA binding surface [nucleotide binding]; other site
1075089000014	dimer interface [polypeptide binding]; other site
1075089000015	beta-clamp/clamp loader binding surface; other site
1075089000016	beta-clamp/translesion DNA polymerase binding surface; other site
1075089000017	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
1075089000018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1075089000019	Walker A/P-loop; other site
1075089000020	ATP binding site [chemical binding]; other site
1075089000021	Q-loop/lid; other site
1075089000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1075089000023	ABC transporter signature motif; other site
1075089000024	Walker B; other site
1075089000025	D-loop; other site
1075089000026	H-loop/switch region; other site
1075089000027	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1075089000028	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089000029	S-adenosylmethionine binding site [chemical binding]; other site
1075089000030	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
1075089000031	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1075089000032	ligand binding site [chemical binding]; other site
1075089000033	flexible hinge region; other site
1075089000034	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1075089000035	putative switch regulator; other site
1075089000036	non-specific DNA interactions [nucleotide binding]; other site
1075089000037	DNA binding site [nucleotide binding]
1075089000038	sequence specific DNA binding site [nucleotide binding]; other site
1075089000039	putative cAMP binding site [chemical binding]; other site
1075089000040	hypothetical protein; Provisional; Region: PRK04966
1075089000041	division inhibitor protein; Provisional; Region: slmA; PRK09480
1075089000042	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1075089000043	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1075089000044	trimer interface [polypeptide binding]; other site
1075089000045	active site
1075089000046	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1075089000047	Flavoprotein; Region: Flavoprotein; pfam02441
1075089000048	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1075089000049	hypothetical protein; Reviewed; Region: PRK00024
1075089000050	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1075089000051	MPN+ (JAMM) motif; other site
1075089000052	Zinc-binding site [ion binding]; other site
1075089000053	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1075089000054	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1075089000055	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1075089000056	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1075089000057	DNA binding site [nucleotide binding]
1075089000058	catalytic residue [active]
1075089000059	H2TH interface [polypeptide binding]; other site
1075089000060	putative catalytic residues [active]
1075089000061	turnover-facilitating residue; other site
1075089000062	intercalation triad [nucleotide binding]; other site
1075089000063	8OG recognition residue [nucleotide binding]; other site
1075089000064	putative reading head residues; other site
1075089000065	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1075089000066	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1075089000067	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1075089000068	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1075089000069	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
1075089000070	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298
1075089000071	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
1075089000072	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
1075089000073	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1075089000074	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1075089000075	active site
1075089000076	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
1075089000077	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
1075089000078	Ligand binding site; other site
1075089000079	metal-binding site
1075089000080	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1075089000081	putative ADP-binding pocket [chemical binding]; other site
1075089000082	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1075089000083	primosome assembly protein PriA; Validated; Region: PRK05580
1075089000084	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1075089000085	ATP binding site [chemical binding]; other site
1075089000086	putative Mg++ binding site [ion binding]; other site
1075089000087	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1075089000088	ATP-binding site [chemical binding]; other site
1075089000089	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
1075089000090	Sporulation related domain; Region: SPOR; pfam05036
1075089000091	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1075089000092	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1075089000093	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1075089000094	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1075089000095	HlyD family secretion protein; Region: HlyD_3; pfam13437
1075089000096	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1075089000097	GAF domain; Region: GAF_2; pfam13185
1075089000098	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1075089000099	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1075089000100	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1075089000101	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1075089000102	ArsC family; Region: ArsC; pfam03960
1075089000103	catalytic residues [active]
1075089000104	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036
1075089000105	argininosuccinate lyase; Provisional; Region: PRK04833
1075089000106	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1075089000107	active sites [active]
1075089000108	tetramer interface [polypeptide binding]; other site
1075089000109	AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249
1075089000110	nucleotide binding site [chemical binding]; other site
1075089000111	N-acetyl-L-glutamate binding site [chemical binding]; other site
1075089000112	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1075089000113	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1075089000114	acetylornithine deacetylase; Provisional; Region: PRK05111
1075089000115	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
1075089000116	metal binding site [ion binding]; metal-binding site
1075089000117	putative dimer interface [polypeptide binding]; other site
1075089000118	Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774
1075089000119	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
1075089000120	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1075089000121	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1075089000122	HIGH motif; other site
1075089000123	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1075089000124	active site
1075089000125	KMSKS motif; other site
1075089000126	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1075089000127	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1075089000128	RNase E interface [polypeptide binding]; other site
1075089000129	trimer interface [polypeptide binding]; other site
1075089000130	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1075089000131	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1075089000132	RNase E interface [polypeptide binding]; other site
1075089000133	trimer interface [polypeptide binding]; other site
1075089000134	active site
1075089000135	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1075089000136	putative nucleic acid binding region [nucleotide binding]; other site
1075089000137	G-X-X-G motif; other site
1075089000138	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1075089000139	RNA binding site [nucleotide binding]; other site
1075089000140	domain interface; other site
1075089000141	Lipoprotein NlpI, contains TPR repeats [General function prediction only]; Region: NlpI; COG4785
1075089000142	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1075089000143	binding surface
1075089000144	TPR motif; other site
1075089000145	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1075089000146	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1075089000147	ATP binding site [chemical binding]; other site
1075089000148	Mg++ binding site [ion binding]; other site
1075089000149	motif III; other site
1075089000150	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1075089000151	nucleotide binding region [chemical binding]; other site
1075089000152	ATP-binding site [chemical binding]; other site
1075089000153	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
1075089000154	putative RNA binding site [nucleotide binding]; other site
1075089000155	molybdenum transport protein ModD; Provisional; Region: PRK06096
1075089000156	ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
1075089000157	dimerization interface [polypeptide binding]; other site
1075089000158	active site
1075089000159	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1075089000160	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1075089000161	Walker A/P-loop; other site
1075089000162	ATP binding site [chemical binding]; other site
1075089000163	Q-loop/lid; other site
1075089000164	ABC transporter signature motif; other site
1075089000165	Walker B; other site
1075089000166	D-loop; other site
1075089000167	H-loop/switch region; other site
1075089000168	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1075089000169	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089000170	putative PBP binding loops; other site
1075089000171	ABC-ATPase subunit interface; other site
1075089000172	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1075089000173	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1075089000174	ring oligomerisation interface [polypeptide binding]; other site
1075089000175	ATP/Mg binding site [chemical binding]; other site
1075089000176	stacking interactions; other site
1075089000177	hinge regions; other site
1075089000178	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1075089000179	oligomerisation interface [polypeptide binding]; other site
1075089000180	mobile loop; other site
1075089000181	roof hairpin; other site
1075089000182	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
1075089000183	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
1075089000184	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
1075089000185	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1075089000186	Aspartase; Region: Aspartase; cd01357
1075089000187	active sites [active]
1075089000188	tetramer interface [polypeptide binding]; other site
1075089000189	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1075089000190	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1075089000191	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
1075089000192	putative C-terminal domain interface [polypeptide binding]; other site
1075089000193	putative GSH binding site (G-site) [chemical binding]; other site
1075089000194	putative dimer interface [polypeptide binding]; other site
1075089000195	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
1075089000196	dimer interface [polypeptide binding]; other site
1075089000197	N-terminal domain interface [polypeptide binding]; other site
1075089000198	putative substrate binding pocket (H-site) [chemical binding]; other site
1075089000199	Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545
1075089000200	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1075089000201	dimer interface [polypeptide binding]; other site
1075089000202	motif 1; other site
1075089000203	active site
1075089000204	motif 2; other site
1075089000205	motif 3; other site
1075089000206	Predicted membrane protein [Function unknown]; Region: COG4325
1075089000207	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
1075089000208	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1075089000209	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1075089000210	substrate binding site [chemical binding]; other site
1075089000211	oxyanion hole (OAH) forming residues; other site
1075089000212	trimer interface [polypeptide binding]; other site
1075089000213	O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441
1075089000214	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
1075089000215	active site
1075089000216	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1075089000217	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1075089000218	active site
1075089000219	trimer interface [polypeptide binding]; other site
1075089000220	dimer interface [polypeptide binding]; other site
1075089000221	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1075089000222	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1075089000223	carboxyltransferase (CT) interaction site; other site
1075089000224	biotinylation site [posttranslational modification]; other site
1075089000225	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1075089000226	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1075089000227	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1075089000228	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1075089000229	Predicted membrane protein [Function unknown]; Region: COG3924
1075089000230	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
1075089000231	Na binding site [ion binding]; other site
1075089000232	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1075089000233	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089000234	S-adenosylmethionine binding site [chemical binding]; other site
1075089000235	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1075089000236	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1075089000237	FMN binding site [chemical binding]; other site
1075089000238	active site
1075089000239	catalytic residues [active]
1075089000240	substrate binding site [chemical binding]; other site
1075089000241	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
1075089000242	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
1075089000243	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
1075089000244	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1075089000245	dimerization interface [polypeptide binding]; other site
1075089000246	ATP binding site [chemical binding]; other site
1075089000247	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1075089000248	dimerization interface [polypeptide binding]; other site
1075089000249	ATP binding site [chemical binding]; other site
1075089000250	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1075089000251	putative active site [active]
1075089000252	catalytic triad [active]
1075089000253	Protein of unknown function DUF262; Region: DUF262; pfam03235
1075089000254	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1075089000255	Protein of unknown function DUF262; Region: DUF262; pfam03235
1075089000256	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
1075089000257	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1075089000258	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1075089000259	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1075089000260	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1075089000261	Walker A/P-loop; other site
1075089000262	ATP binding site [chemical binding]; other site
1075089000263	Q-loop/lid; other site
1075089000264	ABC transporter signature motif; other site
1075089000265	Walker B; other site
1075089000266	D-loop; other site
1075089000267	H-loop/switch region; other site
1075089000268	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1075089000269	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1075089000270	dimer interface [polypeptide binding]; other site
1075089000271	ABC-ATPase subunit  interface; other site
1075089000272	putative PBP binding regions; other site
1075089000273	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1075089000274	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1075089000275	intersubunit interface [polypeptide binding]; other site
1075089000276	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3021
1075089000277	putative catalytic site [active]
1075089000278	putative metal binding site [ion binding]; other site
1075089000279	putative phosphate binding site [ion binding]; other site
1075089000280	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
1075089000281	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1075089000282	active site
1075089000283	substrate binding site [chemical binding]; other site
1075089000284	metal binding site [ion binding]; metal-binding site
1075089000285	putative transporter; Validated; Region: PRK03818
1075089000286	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1075089000287	TrkA-C domain; Region: TrkA_C; pfam02080
1075089000288	TrkA-C domain; Region: TrkA_C; pfam02080
1075089000289	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
1075089000290	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691
1075089000291	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
1075089000292	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1075089000293	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
1075089000294	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1075089000295	DNA binding site [nucleotide binding]
1075089000296	active site
1075089000297	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
1075089000298	putative DNA-binding cleft [nucleotide binding]; other site
1075089000299	putative DNA clevage site; other site
1075089000300	molecular lever; other site
1075089000301	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1075089000302	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1075089000303	DNA polymerase I; Provisional; Region: PRK05755
1075089000304	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1075089000305	active site
1075089000306	metal binding site 1 [ion binding]; metal-binding site
1075089000307	putative 5' ssDNA interaction site; other site
1075089000308	metal binding site 3; metal-binding site
1075089000309	metal binding site 2 [ion binding]; metal-binding site
1075089000310	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1075089000311	putative DNA binding site [nucleotide binding]; other site
1075089000312	putative metal binding site [ion binding]; other site
1075089000313	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
1075089000314	active site
1075089000315	catalytic site [active]
1075089000316	substrate binding site [chemical binding]; other site
1075089000317	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1075089000318	active site
1075089000319	DNA binding site [nucleotide binding]
1075089000320	catalytic site [active]
1075089000321	Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503
1075089000322	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
1075089000323	Mannitol repressor; Region: MtlR; pfam05068
1075089000324	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1075089000325	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1075089000326	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1075089000327	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
1075089000328	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1075089000329	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1075089000330	active site
1075089000331	P-loop; other site
1075089000332	phosphorylation site [posttranslational modification]
1075089000333	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1075089000334	active site
1075089000335	phosphorylation site [posttranslational modification]
1075089000336	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5645
1075089000337	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
1075089000338	Part of AAA domain; Region: AAA_19; pfam13245
1075089000339	Family description; Region: UvrD_C_2; pfam13538
1075089000340	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
1075089000341	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1075089000342	motif II; other site
1075089000343	galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527
1075089000344	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1075089000345	active site
1075089000346	substrate binding site [chemical binding]; other site
1075089000347	trimer interface [polypeptide binding]; other site
1075089000348	CoA binding site [chemical binding]; other site
1075089000349	Predicted membrane protein [Function unknown]; Region: COG1238
1075089000350	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1075089000351	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1075089000352	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1075089000353	ATP-grasp domain; Region: ATP-grasp; pfam02222
1075089000354	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1075089000355	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1075089000356	catalytic triad [active]
1075089000357	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1075089000358	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1075089000359	dimer interface [polypeptide binding]; other site
1075089000360	active site
1075089000361	catalytic residue [active]
1075089000362	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
1075089000363	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1075089000364	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
1075089000365	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1075089000366	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
1075089000367	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
1075089000368	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1075089000369	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1075089000370	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1075089000371	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1075089000372	PhoH-like protein; Region: PhoH; pfam02562
1075089000373	metal-binding heat shock protein; Provisional; Region: PRK00016
1075089000374	phosphodiesterase; Provisional; Region: PRK12704
1075089000375	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
1075089000376	Domain of unknown function (DUF1726); Region: DUF1726; pfam08351
1075089000377	Helicase; Region: Helicase_RecD; pfam05127
1075089000378	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
1075089000379	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
1075089000380	putative metal dependent hydrolase; Provisional; Region: PRK11598
1075089000381	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
1075089000382	Sulfatase; Region: Sulfatase; pfam00884
1075089000383	transcription-repair coupling factor; Provisional; Region: PRK10689
1075089000384	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1075089000385	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1075089000386	ATP binding site [chemical binding]; other site
1075089000387	putative Mg++ binding site [ion binding]; other site
1075089000388	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1075089000389	nucleotide binding region [chemical binding]; other site
1075089000390	ATP-binding site [chemical binding]; other site
1075089000391	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1075089000392	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1075089000393	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1075089000394	TM-ABC transporter signature motif; other site
1075089000395	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1075089000396	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
1075089000397	Walker A/P-loop; other site
1075089000398	ATP binding site [chemical binding]; other site
1075089000399	Q-loop/lid; other site
1075089000400	ABC transporter signature motif; other site
1075089000401	Walker B; other site
1075089000402	D-loop; other site
1075089000403	H-loop/switch region; other site
1075089000404	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1075089000405	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
1075089000406	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
1075089000407	ligand binding site [chemical binding]; other site
1075089000408	calcium binding site [ion binding]; other site
1075089000409	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
1075089000410	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1075089000411	DNA binding site [nucleotide binding]
1075089000412	domain linker motif; other site
1075089000413	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
1075089000414	ligand binding site [chemical binding]; other site
1075089000415	dimerization interface (closed form) [polypeptide binding]; other site
1075089000416	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
1075089000417	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
1075089000418	dimer interface [polypeptide binding]; other site
1075089000419	active site
1075089000420	galactokinase; Provisional; Region: PRK05101
1075089000421	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1075089000422	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1075089000423	active site
1075089000424	catalytic residues [active]
1075089000425	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
1075089000426	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1075089000427	Transporter associated domain; Region: CorC_HlyC; smart01091
1075089000428	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
1075089000429	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1075089000430	putative active site [active]
1075089000431	catalytic triad [active]
1075089000432	putative dimer interface [polypeptide binding]; other site
1075089000433	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1075089000434	rRNA binding site [nucleotide binding]; other site
1075089000435	predicted 30S ribosome binding site; other site
1075089000436	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1075089000437	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1075089000438	NAD binding site [chemical binding]; other site
1075089000439	substrate binding site [chemical binding]; other site
1075089000440	homodimer interface [polypeptide binding]; other site
1075089000441	active site
1075089000442	aminopeptidase B; Provisional; Region: PRK05015
1075089000443	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1075089000444	interface (dimer of trimers) [polypeptide binding]; other site
1075089000445	Substrate-binding/catalytic site; other site
1075089000446	Zn-binding sites [ion binding]; other site
1075089000447	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1075089000448	active site
1075089000449	multimer interface [polypeptide binding]; other site
1075089000450	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1075089000451	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1075089000452	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1075089000453	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1075089000454	hypothetical protein; Provisional; Region: PRK04860
1075089000455	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
1075089000456	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
1075089000457	heat shock protein 90; Provisional; Region: PRK05218
1075089000458	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1075089000459	ATP binding site [chemical binding]; other site
1075089000460	Mg2+ binding site [ion binding]; other site
1075089000461	G-X-G motif; other site
1075089000462	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
1075089000463	ArsC family; Region: ArsC; pfam03960
1075089000464	putative catalytic residues [active]
1075089000465	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
1075089000466	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
1075089000467	metal binding site [ion binding]; metal-binding site
1075089000468	dimer interface [polypeptide binding]; other site
1075089000469	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1075089000470	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1075089000471	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
1075089000472	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1075089000473	dimer interface [polypeptide binding]; other site
1075089000474	ADP-ribose binding site [chemical binding]; other site
1075089000475	active site
1075089000476	nudix motif; other site
1075089000477	metal binding site [ion binding]; metal-binding site
1075089000478	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1075089000479	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1075089000480	active site
1075089000481	metal binding site [ion binding]; metal-binding site
1075089000482	hexamer interface [polypeptide binding]; other site
1075089000483	tyrosine kinase; Provisional; Region: PRK11519
1075089000484	Chain length determinant protein; Region: Wzz; pfam02706
1075089000485	Chain length determinant protein; Region: Wzz; cl15801
1075089000486	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1075089000487	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1075089000488	P loop; other site
1075089000489	Nucleotide binding site [chemical binding]; other site
1075089000490	DTAP/Switch II; other site
1075089000491	Switch I; other site
1075089000492	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1075089000493	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1075089000494	active site
1075089000495	polysaccharide export protein Wza; Provisional; Region: PRK15078
1075089000496	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1075089000497	SLBB domain; Region: SLBB; pfam10531
1075089000498	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1075089000499	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1075089000500	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1075089000501	NAD(P) binding site [chemical binding]; other site
1075089000502	homodimer interface [polypeptide binding]; other site
1075089000503	substrate binding site [chemical binding]; other site
1075089000504	active site
1075089000505	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1075089000506	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1075089000507	inhibitor-cofactor binding pocket; inhibition site
1075089000508	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1075089000509	catalytic residue [active]
1075089000510	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1075089000511	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
1075089000512	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1075089000513	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1075089000514	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
1075089000515	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1075089000516	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1075089000517	active site
1075089000518	homodimer interface [polypeptide binding]; other site
1075089000519	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1075089000520	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1075089000521	NAD(P) binding site [chemical binding]; other site
1075089000522	active site
1075089000523	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
1075089000524	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1075089000525	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1075089000526	Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
1075089000527	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1075089000528	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
1075089000529	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1075089000530	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1075089000531	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
1075089000532	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1075089000533	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
1075089000534	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1075089000535	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1075089000536	FeS/SAM binding site; other site
1075089000537	TRAM domain; Region: TRAM; pfam01938
1075089000538	Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409
1075089000539	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
1075089000540	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
1075089000541	Asp-box motif; other site
1075089000542	catalytic site [active]
1075089000543	C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD); Region: AP_MHD_Cterm; cl10970
1075089000544	Autotransporter beta-domain; Region: Autotransporter; smart00869
1075089000545	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
1075089000546	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
1075089000547	active site
1075089000548	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
1075089000549	macrolide transporter subunit MacA; Provisional; Region: PRK11578
1075089000550	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1075089000551	HlyD family secretion protein; Region: HlyD_3; pfam13437
1075089000552	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
1075089000553	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1075089000554	Walker A/P-loop; other site
1075089000555	ATP binding site [chemical binding]; other site
1075089000556	Q-loop/lid; other site
1075089000557	ABC transporter signature motif; other site
1075089000558	Walker B; other site
1075089000559	D-loop; other site
1075089000560	H-loop/switch region; other site
1075089000561	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1075089000562	FtsX-like permease family; Region: FtsX; pfam02687
1075089000563	cystathionine gamma-synthase; Reviewed; Region: PRK08247
1075089000564	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1075089000565	homodimer interface [polypeptide binding]; other site
1075089000566	substrate-cofactor binding pocket; other site
1075089000567	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1075089000568	catalytic residue [active]
1075089000569	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1075089000570	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1075089000571	catalytic residues [active]
1075089000572	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
1075089000573	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1075089000574	RNA binding surface [nucleotide binding]; other site
1075089000575	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1075089000576	active site
1075089000577	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1075089000578	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1075089000579	homodimer interface [polypeptide binding]; other site
1075089000580	oligonucleotide binding site [chemical binding]; other site
1075089000581	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
1075089000582	Primosomal replication protein N'' [DNA replication, recombination, and repair]; Region: PriC; COG3923
1075089000583	Predicted permease [General function prediction only]; Region: COG2056
1075089000584	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
1075089000585	ribonuclease T; Provisional; Region: PRK05168
1075089000586	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1075089000587	active site
1075089000588	catalytic site [active]
1075089000589	substrate binding site [chemical binding]; other site
1075089000590	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1075089000591	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1075089000592	dimer interface [polypeptide binding]; other site
1075089000593	active site
1075089000594	metal binding site [ion binding]; metal-binding site
1075089000595	glutathione binding site [chemical binding]; other site
1075089000596	Predicted membrane protein [Function unknown]; Region: COG4984
1075089000597	Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925
1075089000598	Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929
1075089000599	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1075089000600	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089000601	S-adenosylmethionine binding site [chemical binding]; other site
1075089000602	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
1075089000603	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1075089000604	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1075089000605	dimer interface [polypeptide binding]; other site
1075089000606	anticodon binding site; other site
1075089000607	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1075089000608	homodimer interface [polypeptide binding]; other site
1075089000609	motif 1; other site
1075089000610	active site
1075089000611	motif 2; other site
1075089000612	GAD domain; Region: GAD; pfam02938
1075089000613	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1075089000614	active site
1075089000615	motif 3; other site
1075089000616	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1075089000617	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
1075089000618	nudix motif; other site
1075089000619	hypothetical protein; Validated; Region: PRK00110
1075089000620	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1075089000621	active site
1075089000622	putative DNA-binding cleft [nucleotide binding]; other site
1075089000623	dimer interface [polypeptide binding]; other site
1075089000624	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1075089000625	RuvA N terminal domain; Region: RuvA_N; pfam01330
1075089000626	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1075089000627	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1075089000628	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1075089000629	Walker A motif; other site
1075089000630	ATP binding site [chemical binding]; other site
1075089000631	Walker B motif; other site
1075089000632	arginine finger; other site
1075089000633	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1075089000634	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1075089000635	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
1075089000636	cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203
1075089000637	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1075089000638	Predicted membrane protein [Function unknown]; Region: COG3790
1075089000639	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1075089000640	active site
1075089000641	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1075089000642	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1075089000643	colicin uptake protein TolR; Provisional; Region: PRK11024
1075089000644	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
1075089000645	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
1075089000646	TolA C-terminal; Region: TolA; pfam06519
1075089000647	translocation protein TolB; Provisional; Region: tolB; PRK01742
1075089000648	TolB amino-terminal domain; Region: TolB_N; pfam04052
1075089000649	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1075089000650	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1075089000651	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1075089000652	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1075089000653	ligand binding site [chemical binding]; other site
1075089000654	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
1075089000655	Protein of unknown function (DUF2572); Region: DUF2572; pfam10833
1075089000656	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
1075089000657	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
1075089000658	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
1075089000659	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
1075089000660	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1075089000661	Coenzyme A binding pocket [chemical binding]; other site
1075089000662	DNA polymerase III, psi subunit [DNA replication, recombination, and repair]; Region: HolD; COG3050
1075089000663	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
1075089000664	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
1075089000665	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089000666	S-adenosylmethionine binding site [chemical binding]; other site
1075089000667	ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432
1075089000668	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1075089000669	Walker A/P-loop; other site
1075089000670	ATP binding site [chemical binding]; other site
1075089000671	Q-loop/lid; other site
1075089000672	ABC transporter signature motif; other site
1075089000673	Walker B; other site
1075089000674	D-loop; other site
1075089000675	H-loop/switch region; other site
1075089000676	TOBE domain; Region: TOBE_2; pfam08402
1075089000677	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1075089000678	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089000679	dimer interface [polypeptide binding]; other site
1075089000680	conserved gate region; other site
1075089000681	putative PBP binding loops; other site
1075089000682	ABC-ATPase subunit interface; other site
1075089000683	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089000684	dimer interface [polypeptide binding]; other site
1075089000685	conserved gate region; other site
1075089000686	putative PBP binding loops; other site
1075089000687	ABC-ATPase subunit interface; other site
1075089000688	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1075089000689	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1075089000690	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1075089000691	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1075089000692	ATP-binding site [chemical binding]; other site
1075089000693	Sugar specificity; other site
1075089000694	Pyrimidine base specificity; other site
1075089000695	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1075089000696	trimer interface [polypeptide binding]; other site
1075089000697	active site
1075089000698	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1075089000699	putative arabinose transporter; Provisional; Region: PRK03545
1075089000700	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1075089000701	putative substrate translocation pore; other site
1075089000702	putative transporter; Provisional; Region: PRK11660
1075089000703	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1075089000704	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1075089000705	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1075089000706	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
1075089000707	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1075089000708	active site
1075089000709	intersubunit interface [polypeptide binding]; other site
1075089000710	catalytic residue [active]
1075089000711	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979
1075089000712	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
1075089000713	putative metal binding site [ion binding]; other site
1075089000714	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1075089000715	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1075089000716	active site
1075089000717	HIGH motif; other site
1075089000718	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1075089000719	KMSKS motif; other site
1075089000720	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
1075089000721	tRNA binding surface [nucleotide binding]; other site
1075089000722	anticodon binding site; other site
1075089000723	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
1075089000724	substrate binding site [chemical binding]; other site
1075089000725	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
1075089000726	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
1075089000727	substrate binding site [chemical binding]; other site
1075089000728	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1075089000729	active site
1075089000730	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
1075089000731	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1075089000732	FeS/SAM binding site; other site
1075089000733	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
1075089000734	ATP cone domain; Region: ATP-cone; pfam03477
1075089000735	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1075089000736	effector binding site; other site
1075089000737	active site
1075089000738	Zn binding site [ion binding]; other site
1075089000739	glycine loop; other site
1075089000740	Haem-binding domain; Region: Haem_bd; pfam14376
1075089000741	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
1075089000742	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1075089000743	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1075089000744	GDP-binding site [chemical binding]; other site
1075089000745	ACT binding site; other site
1075089000746	IMP binding site; other site
1075089000747	aspartate kinase III; Validated; Region: PRK09084
1075089000748	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1075089000749	nucleotide binding site [chemical binding]; other site
1075089000750	substrate binding site [chemical binding]; other site
1075089000751	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932
1075089000752	lysine allosteric regulatory site; other site
1075089000753	dimer interface [polypeptide binding]; other site
1075089000754	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
1075089000755	dimer interface [polypeptide binding]; other site
1075089000756	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1075089000757	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1075089000758	putative catalytic cysteine [active]
1075089000759	Predicted membrane protein [Function unknown]; Region: COG2860
1075089000760	UPF0126 domain; Region: UPF0126; pfam03458
1075089000761	UPF0126 domain; Region: UPF0126; pfam03458
1075089000762	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1075089000763	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069
1075089000764	hypothetical protein; Provisional; Region: PRK07338
1075089000765	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
1075089000766	metal binding site [ion binding]; metal-binding site
1075089000767	dimer interface [polypeptide binding]; other site
1075089000768	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
1075089000769	AMP binding site [chemical binding]; other site
1075089000770	metal binding site [ion binding]; metal-binding site
1075089000771	active site
1075089000772	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
1075089000773	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1075089000774	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1075089000775	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1075089000776	murein transglycosylase A; Provisional; Region: mltA; PRK11162
1075089000777	MltA specific insert domain; Region: MltA; smart00925
1075089000778	3D domain; Region: 3D; pfam06725
1075089000779	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1075089000780	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1075089000781	putative ATP binding site [chemical binding]; other site
1075089000782	putative substrate interface [chemical binding]; other site
1075089000783	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1075089000784	intersubunit interface [polypeptide binding]; other site
1075089000785	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
1075089000786	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
1075089000787	metal binding site [ion binding]; metal-binding site
1075089000788	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1075089000789	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1075089000790	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1075089000791	acyl-activating enzyme (AAE) consensus motif; other site
1075089000792	putative AMP binding site [chemical binding]; other site
1075089000793	putative active site [active]
1075089000794	putative CoA binding site [chemical binding]; other site
1075089000795	Entericidin EcnA/B family; Region: Entericidin; cl02322
1075089000796	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
1075089000797	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1075089000798	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1075089000799	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1075089000800	SelR domain; Region: SelR; pfam01641
1075089000801	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1075089000802	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1075089000803	catalytic site [active]
1075089000804	G-X2-G-X-G-K; other site
1075089000805	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
1075089000806	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
1075089000807	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1075089000808	Zn2+ binding site [ion binding]; other site
1075089000809	Mg2+ binding site [ion binding]; other site
1075089000810	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1075089000811	synthetase active site [active]
1075089000812	NTP binding site [chemical binding]; other site
1075089000813	metal binding site [ion binding]; metal-binding site
1075089000814	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1075089000815	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1075089000816	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1075089000817	Pathogenicity locus; Region: Cdd1; pfam11731
1075089000818	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1075089000819	generic binding surface II; other site
1075089000820	ssDNA binding site; other site
1075089000821	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1075089000822	ATP binding site [chemical binding]; other site
1075089000823	putative Mg++ binding site [ion binding]; other site
1075089000824	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1075089000825	nucleotide binding region [chemical binding]; other site
1075089000826	ATP-binding site [chemical binding]; other site
1075089000827	Chorismate lyase; Region: Chor_lyase; cl01230
1075089000828	glutamate racemase; Provisional; Region: PRK00865
1075089000829	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
1075089000830	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1075089000831	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1075089000832	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1075089000833	active site
1075089000834	catalytic residues [active]
1075089000835	DNA binding site [nucleotide binding]
1075089000836	Int/Topo IB signature motif; other site
1075089000837	Helix-turn-helix domain; Region: HTH_38; pfam13936
1075089000838	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1075089000839	Integrase core domain; Region: rve; pfam00665
1075089000840	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
1075089000841	Phosphotransferase enzyme family; Region: APH; pfam01636
1075089000842	active site
1075089000843	ATP binding site [chemical binding]; other site
1075089000844	antibiotic binding site [chemical binding]; other site
1075089000845	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655
1075089000846	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
1075089000847	Phosphotransferase enzyme family; Region: APH; pfam01636
1075089000848	active site
1075089000849	ATP binding site [chemical binding]; other site
1075089000850	antibiotic binding site [chemical binding]; other site
1075089000851	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1075089000852	substrate binding pocket [chemical binding]; other site
1075089000853	dimer interface [polypeptide binding]; other site
1075089000854	inhibitor binding site; inhibition site
1075089000855	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
1075089000856	Putative transposase; Region: Y2_Tnp; pfam04986
1075089000857	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1075089000858	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1075089000859	putative substrate translocation pore; other site
1075089000860	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1075089000861	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1075089000862	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
1075089000863	Putative transposase; Region: Y2_Tnp; pfam04986
1075089000864	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
1075089000865	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089000866	S-adenosylmethionine binding site [chemical binding]; other site
1075089000867	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1075089000868	active site
1075089000869	catalytic residues [active]
1075089000870	DNA binding site [nucleotide binding]
1075089000871	Int/Topo IB signature motif; other site
1075089000872	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
1075089000873	Putative helicase; Region: TraI_2; pfam07514
1075089000874	Protein of unknown function (DUF1528); Region: DUF1528; pfam07515
1075089000875	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1075089000876	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
1075089000877	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
1075089000878	Protein of unknown function (DUF1525); Region: DUF1525; pfam07511
1075089000879	integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756
1075089000880	integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755
1075089000881	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1075089000882	catalytic residue [active]
1075089000883	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
1075089000884	conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744
1075089000885	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
1075089000886	conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751
1075089000887	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
1075089000888	Protein of unknown function (DUF3438); Region: DUF3438; pfam11920
1075089000889	Protein of unknown function (DUF2895); Region: DUF2895; pfam11444
1075089000890	Protein of unknown function (DUF3487); Region: DUF3487; pfam11990
1075089000891	Protein of unknown function (DUF2976); Region: DUF2976; pfam11190
1075089000892	Protein of unknown function (DUF3262); Region: DUF3262; pfam11660
1075089000893	integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690
1075089000894	Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686
1075089000895	integrating conjugative element membrane protein, PFL_4697 family; Region: conj_TIGR03747
1075089000896	conjugative coupling factor TraD, TOL family; Region: conj_TOL_TraD; TIGR03754
1075089000897	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
1075089000898	Protein of unknown function (DUF2859); Region: DUF2859; pfam11072
1075089000899	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1075089000900	catalytic residue [active]
1075089000901	integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759
1075089000902	conjugative transfer region protein, TIGR03748 family; Region: conj_PilL
1075089000903	Protein of unknown function (DUF3577); Region: DUF3577; pfam12101
1075089000904	DNA topoisomerase III; Provisional; Region: PRK07726
1075089000905	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1075089000906	active site
1075089000907	putative interdomain interaction site [polypeptide binding]; other site
1075089000908	putative metal-binding site [ion binding]; other site
1075089000909	putative nucleotide binding site [chemical binding]; other site
1075089000910	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1075089000911	domain I; other site
1075089000912	DNA binding groove [nucleotide binding]
1075089000913	phosphate binding site [ion binding]; other site
1075089000914	domain II; other site
1075089000915	domain III; other site
1075089000916	nucleotide binding site [chemical binding]; other site
1075089000917	catalytic site [active]
1075089000918	domain IV; other site
1075089000919	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1075089000920	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1075089000921	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1075089000922	active site
1075089000923	Predicted metal-binding protein [General function prediction only]; Region: COG3019
1075089000924	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1075089000925	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1075089000926	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1075089000927	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1075089000928	NADH kinase; Region: PLN02929
1075089000929	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1075089000930	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1075089000931	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1075089000932	Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706
1075089000933	aminoglycoside resistance protein; Provisional; Region: PRK13746
1075089000934	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1075089000935	active site
1075089000936	NTP binding site [chemical binding]; other site
1075089000937	metal binding triad [ion binding]; metal-binding site
1075089000938	antibiotic binding site [chemical binding]; other site
1075089000939	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1075089000940	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
1075089000941	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1075089000942	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1075089000943	Integrase core domain; Region: rve; pfam00665
1075089000944	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1075089000945	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1075089000946	ABC transporter; Region: ABC_tran_2; pfam12848
1075089000947	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1075089000948	Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152
1075089000949	putative active site [active]
1075089000950	putative substrate binding site [chemical binding]; other site
1075089000951	Phosphotransferase enzyme family; Region: APH; pfam01636
1075089000952	ATP binding site [chemical binding]; other site
1075089000953	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1075089000954	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1075089000955	Integrase core domain; Region: rve; pfam00665
1075089000956	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1075089000957	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1075089000958	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1075089000959	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1075089000960	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1075089000961	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1075089000962	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1075089000963	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1075089000964	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1075089000965	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1075089000966	dimer interface [polypeptide binding]; other site
1075089000967	ssDNA binding site [nucleotide binding]; other site
1075089000968	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1075089000969	Protein of unknown function (DUF3158); Region: DUF3158; pfam11358
1075089000970	Domain of unknown function (DUF1845); Region: DUF1845; pfam08900
1075089000971	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
1075089000972	integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764
1075089000973	ParB-like nuclease domain; Region: ParBc; pfam02195
1075089000974	replicative DNA helicase; Region: DnaB; TIGR00665
1075089000975	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1075089000976	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1075089000977	Walker A motif; other site
1075089000978	ATP binding site [chemical binding]; other site
1075089000979	Walker B motif; other site
1075089000980	DNA binding loops [nucleotide binding]
1075089000981	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1075089000982	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1075089000983	P-loop; other site
1075089000984	Magnesium ion binding site [ion binding]; other site
1075089000985	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721
1075089000986	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
1075089000987	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1075089000988	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1075089000989	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1075089000990	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1075089000991	16S/18S rRNA binding site [nucleotide binding]; other site
1075089000992	S13e-L30e interaction site [polypeptide binding]; other site
1075089000993	25S rRNA binding site [nucleotide binding]; other site
1075089000994	antiporter inner membrane protein; Provisional; Region: PRK11670
1075089000995	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1075089000996	Walker A motif; other site
1075089000997	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
1075089000998	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1075089000999	active site
1075089001000	HIGH motif; other site
1075089001001	KMSKS motif; other site
1075089001002	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1075089001003	tRNA binding surface [nucleotide binding]; other site
1075089001004	anticodon binding site; other site
1075089001005	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1075089001006	dimer interface [polypeptide binding]; other site
1075089001007	putative tRNA-binding site [nucleotide binding]; other site
1075089001008	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
1075089001009	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1075089001010	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089001011	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1075089001012	putative RNA binding site [nucleotide binding]; other site
1075089001013	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089001014	S-adenosylmethionine binding site [chemical binding]; other site
1075089001015	CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829
1075089001016	CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09676
1075089001017	CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09677
1075089001018	CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09674
1075089001019	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718
1075089001020	CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673
1075089001021	CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562
1075089001022	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1075089001023	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1075089001024	dimer interface [polypeptide binding]; other site
1075089001025	phosphorylation site [posttranslational modification]
1075089001026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1075089001027	ATP binding site [chemical binding]; other site
1075089001028	Mg2+ binding site [ion binding]; other site
1075089001029	G-X-G motif; other site
1075089001030	Response regulator receiver domain; Region: Response_reg; pfam00072
1075089001031	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1075089001032	active site
1075089001033	phosphorylation site [posttranslational modification]
1075089001034	intermolecular recognition site; other site
1075089001035	dimerization interface [polypeptide binding]; other site
1075089001036	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1075089001037	putative binding surface; other site
1075089001038	active site
1075089001039	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1075089001040	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1075089001041	active site
1075089001042	dimerization interface [polypeptide binding]; other site
1075089001043	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
1075089001044	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1075089001045	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
1075089001046	Rrf2 family protein; Region: rrf2_super; TIGR00738
1075089001047	cysteine desulfurase; Provisional; Region: PRK14012
1075089001048	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1075089001049	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1075089001050	catalytic residue [active]
1075089001051	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1075089001052	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1075089001053	trimerization site [polypeptide binding]; other site
1075089001054	active site
1075089001055	iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011
1075089001056	co-chaperone HscB; Provisional; Region: hscB; PRK05014
1075089001057	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1075089001058	HSP70 interaction site [polypeptide binding]; other site
1075089001059	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
1075089001060	chaperone protein HscA; Provisional; Region: hscA; PRK05183
1075089001061	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
1075089001062	nucleotide binding site [chemical binding]; other site
1075089001063	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1075089001064	SBD interface [polypeptide binding]; other site
1075089001065	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1075089001066	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1075089001067	catalytic loop [active]
1075089001068	iron binding site [ion binding]; other site
1075089001069	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
1075089001070	Transglycosylase; Region: Transgly; cl17702
1075089001071	Trp operon repressor; Provisional; Region: PRK01381
1075089001072	lytic murein transglycosylase; Provisional; Region: PRK11619
1075089001073	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1075089001074	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1075089001075	catalytic residue [active]
1075089001076	YciI-like protein; Reviewed; Region: PRK11370
1075089001077	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1075089001078	intracellular septation protein A; Reviewed; Region: PRK00259
1075089001079	OmpW family; Region: OmpW; cl17427
1075089001080	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1075089001081	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1075089001082	Walker A/P-loop; other site
1075089001083	ATP binding site [chemical binding]; other site
1075089001084	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1075089001085	Q-loop/lid; other site
1075089001086	ABC transporter signature motif; other site
1075089001087	Walker B; other site
1075089001088	D-loop; other site
1075089001089	H-loop/switch region; other site
1075089001090	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
1075089001091	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
1075089001092	GrpE; Region: GrpE; pfam01025
1075089001093	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1075089001094	dimer interface [polypeptide binding]; other site
1075089001095	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1075089001096	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
1075089001097	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1075089001098	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1075089001099	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1075089001100	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
1075089001101	Uncharacterized conserved protein [Function unknown]; Region: COG4121
1075089001102	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
1075089001103	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1075089001104	dimer interface [polypeptide binding]; other site
1075089001105	active site
1075089001106	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1075089001107	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089001108	S-adenosylmethionine binding site [chemical binding]; other site
1075089001109	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1075089001110	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1075089001111	Na binding site [ion binding]; other site
1075089001112	ribonuclease G; Provisional; Region: PRK11712
1075089001113	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1075089001114	homodimer interface [polypeptide binding]; other site
1075089001115	oligonucleotide binding site [chemical binding]; other site
1075089001116	protease TldD; Provisional; Region: tldD; PRK10735
1075089001117	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
1075089001118	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1075089001119	inhibitor-cofactor binding pocket; inhibition site
1075089001120	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1075089001121	catalytic residue [active]
1075089001122	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
1075089001123	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1075089001124	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1075089001125	substrate binding pocket [chemical binding]; other site
1075089001126	chain length determination region; other site
1075089001127	substrate-Mg2+ binding site; other site
1075089001128	catalytic residues [active]
1075089001129	aspartate-rich region 1; other site
1075089001130	active site lid residues [active]
1075089001131	aspartate-rich region 2; other site
1075089001132	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1075089001133	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1075089001134	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1075089001135	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1075089001136	EamA-like transporter family; Region: EamA; pfam00892
1075089001137	EamA-like transporter family; Region: EamA; pfam00892
1075089001138	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1075089001139	EamA-like transporter family; Region: EamA; pfam00892
1075089001140	EamA-like transporter family; Region: EamA; pfam00892
1075089001141	GTPase CgtA; Reviewed; Region: obgE; PRK12298
1075089001142	GTP1/OBG; Region: GTP1_OBG; pfam01018
1075089001143	Obg GTPase; Region: Obg; cd01898
1075089001144	G1 box; other site
1075089001145	GTP/Mg2+ binding site [chemical binding]; other site
1075089001146	Switch I region; other site
1075089001147	G2 box; other site
1075089001148	G3 box; other site
1075089001149	Switch II region; other site
1075089001150	G4 box; other site
1075089001151	G5 box; other site
1075089001152	ferric uptake regulator; Provisional; Region: fur; PRK09462
1075089001153	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1075089001154	metal binding site 2 [ion binding]; metal-binding site
1075089001155	putative DNA binding helix; other site
1075089001156	metal binding site 1 [ion binding]; metal-binding site
1075089001157	dimer interface [polypeptide binding]; other site
1075089001158	structural Zn2+ binding site [ion binding]; other site
1075089001159	flavodoxin FldA; Validated; Region: PRK09267
1075089001160	LexA regulated protein; Provisional; Region: PRK11675
1075089001161	acyl-CoA esterase; Provisional; Region: PRK10673
1075089001162	PGAP1-like protein; Region: PGAP1; pfam07819
1075089001163	replication initiation regulator SeqA; Provisional; Region: PRK11187
1075089001164	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
1075089001165	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
1075089001166	acyl-activating enzyme (AAE) consensus motif; other site
1075089001167	putative AMP binding site [chemical binding]; other site
1075089001168	putative active site [active]
1075089001169	putative CoA binding site [chemical binding]; other site
1075089001170	hypothetical protein; Provisional; Region: PRK11281
1075089001171	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
1075089001172	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1075089001173	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1075089001174	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1075089001175	Tetramer interface [polypeptide binding]; other site
1075089001176	active site
1075089001177	FMN-binding site [chemical binding]; other site
1075089001178	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
1075089001179	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
1075089001180	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1075089001181	hypothetical protein; Provisional; Region: PRK10621
1075089001182	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1075089001183	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1075089001184	putative acyl-acceptor binding pocket; other site
1075089001185	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1075089001186	active site
1075089001187	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
1075089001188	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1075089001189	Walker A motif; other site
1075089001190	ATP binding site [chemical binding]; other site
1075089001191	Walker B motif; other site
1075089001192	arginine finger; other site
1075089001193	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1075089001194	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
1075089001195	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1075089001196	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1075089001197	homotrimer interaction site [polypeptide binding]; other site
1075089001198	putative active site [active]
1075089001199	YwiC-like protein; Region: YwiC; pfam14256
1075089001200	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1075089001201	Sel1-like repeats; Region: SEL1; smart00671
1075089001202	Sel1 repeat; Region: Sel1; cl02723
1075089001203	Sel1-like repeats; Region: SEL1; smart00671
1075089001204	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1075089001205	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1075089001206	CAP-like domain; other site
1075089001207	active site
1075089001208	primary dimer interface [polypeptide binding]; other site
1075089001209	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1075089001210	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1075089001211	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1075089001212	ATP binding site [chemical binding]; other site
1075089001213	Mg2+ binding site [ion binding]; other site
1075089001214	G-X-G motif; other site
1075089001215	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1075089001216	anchoring element; other site
1075089001217	dimer interface [polypeptide binding]; other site
1075089001218	ATP binding site [chemical binding]; other site
1075089001219	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
1075089001220	active site
1075089001221	putative metal-binding site [ion binding]; other site
1075089001222	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1075089001223	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
1075089001224	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
1075089001225	dimer interface [polypeptide binding]; other site
1075089001226	active site
1075089001227	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1075089001228	catalytic residues [active]
1075089001229	substrate binding site [chemical binding]; other site
1075089001230	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
1075089001231	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1075089001232	NAD(P) binding pocket [chemical binding]; other site
1075089001233	BtpA family; Region: BtpA; cl00440
1075089001234	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
1075089001235	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1075089001236	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089001237	S-adenosylmethionine binding site [chemical binding]; other site
1075089001238	Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797
1075089001239	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
1075089001240	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1075089001241	metal binding triad; other site
1075089001242	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1075089001243	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1075089001244	metal binding triad; other site
1075089001245	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1075089001246	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1075089001247	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
1075089001248	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
1075089001249	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089001250	dimer interface [polypeptide binding]; other site
1075089001251	conserved gate region; other site
1075089001252	putative PBP binding loops; other site
1075089001253	ABC-ATPase subunit interface; other site
1075089001254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089001255	dimer interface [polypeptide binding]; other site
1075089001256	conserved gate region; other site
1075089001257	putative PBP binding loops; other site
1075089001258	ABC-ATPase subunit interface; other site
1075089001259	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
1075089001260	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1075089001261	Walker A/P-loop; other site
1075089001262	ATP binding site [chemical binding]; other site
1075089001263	Q-loop/lid; other site
1075089001264	ABC transporter signature motif; other site
1075089001265	Walker B; other site
1075089001266	D-loop; other site
1075089001267	H-loop/switch region; other site
1075089001268	biotin synthase; Region: bioB; TIGR00433
1075089001269	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1075089001270	FeS/SAM binding site; other site
1075089001271	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
1075089001272	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1075089001273	Na2 binding site [ion binding]; other site
1075089001274	putative substrate binding site 1 [chemical binding]; other site
1075089001275	Na binding site 1 [ion binding]; other site
1075089001276	putative substrate binding site 2 [chemical binding]; other site
1075089001277	endonuclease III; Provisional; Region: PRK10702
1075089001278	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1075089001279	minor groove reading motif; other site
1075089001280	helix-hairpin-helix signature motif; other site
1075089001281	substrate binding pocket [chemical binding]; other site
1075089001282	active site
1075089001283	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1075089001284	electron transport complex RsxE subunit; Provisional; Region: PRK12405
1075089001285	electron transport complex protein RnfG; Validated; Region: PRK01908
1075089001286	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
1075089001287	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
1075089001288	SLBB domain; Region: SLBB; pfam10531
1075089001289	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1075089001290	electron transport complex protein RnfB; Provisional; Region: PRK05113
1075089001291	Putative Fe-S cluster; Region: FeS; pfam04060
1075089001292	4Fe-4S binding domain; Region: Fer4; pfam00037
1075089001293	4Fe-4S binding domain; Region: Fer4; cl02805
1075089001294	electron transport complex protein RsxA; Provisional; Region: PRK05151
1075089001295	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1075089001296	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1075089001297	eyelet of channel; other site
1075089001298	trimer interface [polypeptide binding]; other site
1075089001299	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1075089001300	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1075089001301	trimer interface [polypeptide binding]; other site
1075089001302	eyelet of channel; other site
1075089001303	HemK family putative methylases; Region: hemK_fam; TIGR00536
1075089001304	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089001305	S-adenosylmethionine binding site [chemical binding]; other site
1075089001306	hypothetical protein; Provisional; Region: PRK04946
1075089001307	Smr domain; Region: Smr; pfam01713
1075089001308	TIGR01666 family membrane protein; Region: YCCS
1075089001309	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
1075089001310	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1075089001311	Predicted membrane protein [Function unknown]; Region: COG3304
1075089001312	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1075089001313	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1075089001314	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
1075089001315	active site
1075089001316	dimer interfaces [polypeptide binding]; other site
1075089001317	catalytic residues [active]
1075089001318	hypothetical protein; Provisional; Region: PRK01904
1075089001319	Acylphosphatase; Region: Acylphosphatase; cl00551
1075089001320	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1075089001321	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1075089001322	ABC-ATPase subunit  interface; other site
1075089001323	dimer interface [polypeptide binding]; other site
1075089001324	putative PBP binding regions; other site
1075089001325	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1075089001326	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1075089001327	ABC-ATPase subunit  interface; other site
1075089001328	dimer interface [polypeptide binding]; other site
1075089001329	putative PBP binding regions; other site
1075089001330	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
1075089001331	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1075089001332	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1075089001333	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1075089001334	metal binding site [ion binding]; metal-binding site
1075089001335	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
1075089001336	DsrC like protein; Region: DsrC; pfam04358
1075089001337	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1075089001338	YccA-like proteins; Region: YccA_like; cd10433
1075089001339	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
1075089001340	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
1075089001341	Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864
1075089001342	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
1075089001343	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
1075089001344	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
1075089001345	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
1075089001346	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
1075089001347	[4Fe-4S] binding site [ion binding]; other site
1075089001348	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1075089001349	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1075089001350	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1075089001351	molybdopterin cofactor binding site; other site
1075089001352	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1075089001353	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
1075089001354	Part of AAA domain; Region: AAA_19; pfam13245
1075089001355	Family description; Region: UvrD_C_2; pfam13538
1075089001356	replicative DNA helicase; Validated; Region: PRK06904
1075089001357	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1075089001358	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1075089001359	Walker A motif; other site
1075089001360	ATP binding site [chemical binding]; other site
1075089001361	Walker B motif; other site
1075089001362	DNA binding loops [nucleotide binding]
1075089001363	alanine racemase; Reviewed; Region: alr; PRK00053
1075089001364	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
1075089001365	active site
1075089001366	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1075089001367	substrate binding site [chemical binding]; other site
1075089001368	catalytic residues [active]
1075089001369	dimer interface [polypeptide binding]; other site
1075089001370	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1075089001371	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1075089001372	active site
1075089001373	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1075089001374	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1075089001375	active site
1075089001376	dimer interface [polypeptide binding]; other site
1075089001377	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1075089001378	dimer interface [polypeptide binding]; other site
1075089001379	active site
1075089001380	Predicted transcriptional regulator [Transcription]; Region: COG2932
1075089001381	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
1075089001382	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1075089001383	Catalytic site [active]
1075089001384	Predicted transcriptional regulator [Transcription]; Region: Nlp; COG3423
1075089001385	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
1075089001386	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1075089001387	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1075089001388	THF binding site; other site
1075089001389	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1075089001390	substrate binding site [chemical binding]; other site
1075089001391	THF binding site; other site
1075089001392	zinc-binding site [ion binding]; other site
1075089001393	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
1075089001394	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1075089001395	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
1075089001396	putative dimerization interface [polypeptide binding]; other site
1075089001397	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1075089001398	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1075089001399	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1075089001400	ABC transporter; Region: ABC_tran_2; pfam12848
1075089001401	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1075089001402	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
1075089001403	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
1075089001404	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
1075089001405	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1075089001406	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1075089001407	excinuclease ABC subunit B; Provisional; Region: PRK05298
1075089001408	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
1075089001409	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1075089001410	ATP-binding site [chemical binding]; other site
1075089001411	ATP binding site [chemical binding]; other site
1075089001412	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1075089001413	nucleotide binding region [chemical binding]; other site
1075089001414	ATP-binding site [chemical binding]; other site
1075089001415	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1075089001416	UvrB/uvrC motif; Region: UVR; pfam02151
1075089001417	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
1075089001418	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1075089001419	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1075089001420	putative active site [active]
1075089001421	heme pocket [chemical binding]; other site
1075089001422	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1075089001423	dimer interface [polypeptide binding]; other site
1075089001424	phosphorylation site [posttranslational modification]
1075089001425	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1075089001426	ATP binding site [chemical binding]; other site
1075089001427	Mg2+ binding site [ion binding]; other site
1075089001428	G-X-G motif; other site
1075089001429	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
1075089001430	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1075089001431	active site
1075089001432	phosphorylation site [posttranslational modification]
1075089001433	intermolecular recognition site; other site
1075089001434	dimerization interface [polypeptide binding]; other site
1075089001435	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1075089001436	DNA binding site [nucleotide binding]
1075089001437	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
1075089001438	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1075089001439	Walker A/P-loop; other site
1075089001440	ATP binding site [chemical binding]; other site
1075089001441	Q-loop/lid; other site
1075089001442	ABC transporter signature motif; other site
1075089001443	Walker B; other site
1075089001444	D-loop; other site
1075089001445	H-loop/switch region; other site
1075089001446	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
1075089001447	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089001448	dimer interface [polypeptide binding]; other site
1075089001449	conserved gate region; other site
1075089001450	putative PBP binding loops; other site
1075089001451	ABC-ATPase subunit interface; other site
1075089001452	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1075089001453	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089001454	dimer interface [polypeptide binding]; other site
1075089001455	conserved gate region; other site
1075089001456	putative PBP binding loops; other site
1075089001457	ABC-ATPase subunit interface; other site
1075089001458	PBP superfamily domain; Region: PBP_like_2; cl17296
1075089001459	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
1075089001460	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089001461	S-adenosylmethionine binding site [chemical binding]; other site
1075089001462	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
1075089001463	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1075089001464	Walker A motif; other site
1075089001465	ATP binding site [chemical binding]; other site
1075089001466	Walker B motif; other site
1075089001467	arginine finger; other site
1075089001468	Peptidase family M41; Region: Peptidase_M41; pfam01434
1075089001469	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1075089001470	dihydropteroate synthase; Region: DHPS; TIGR01496
1075089001471	substrate binding pocket [chemical binding]; other site
1075089001472	dimer interface [polypeptide binding]; other site
1075089001473	inhibitor binding site; inhibition site
1075089001474	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
1075089001475	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1075089001476	active site
1075089001477	substrate binding site [chemical binding]; other site
1075089001478	metal binding site [ion binding]; metal-binding site
1075089001479	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1075089001480	catalytic core [active]
1075089001481	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
1075089001482	Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850
1075089001483	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1075089001484	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100
1075089001485	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013
1075089001486	Cytochrome c553 [Energy production and conversion]; Region: COG2863
1075089001487	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1075089001488	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1075089001489	catalytic residues [active]
1075089001490	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1075089001491	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1075089001492	Walker A/P-loop; other site
1075089001493	ATP binding site [chemical binding]; other site
1075089001494	Q-loop/lid; other site
1075089001495	ABC transporter signature motif; other site
1075089001496	Walker B; other site
1075089001497	D-loop; other site
1075089001498	H-loop/switch region; other site
1075089001499	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1075089001500	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1075089001501	FtsX-like permease family; Region: FtsX; pfam02687
1075089001502	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1075089001503	FtsX-like permease family; Region: FtsX; pfam02687
1075089001504	Predicted membrane protein [Function unknown]; Region: COG4393
1075089001505	Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080
1075089001506	Uncharacterized conserved protein [Function unknown]; Region: COG3350
1075089001507	Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470
1075089001508	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
1075089001509	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
1075089001510	active site pocket [active]
1075089001511	oxyanion hole [active]
1075089001512	catalytic triad [active]
1075089001513	active site nucleophile [active]
1075089001514	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
1075089001515	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
1075089001516	Transglycosylase; Region: Transgly; pfam00912
1075089001517	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1075089001518	Uncharacterized protein family (UPF0231); Region: UPF0231; cl11474
1075089001519	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
1075089001520	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1075089001521	active site
1075089001522	PII uridylyl-transferase; Provisional; Region: glnD; PRK01759
1075089001523	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1075089001524	metal binding triad; other site
1075089001525	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1075089001526	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1075089001527	Zn2+ binding site [ion binding]; other site
1075089001528	Mg2+ binding site [ion binding]; other site
1075089001529	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
1075089001530	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
1075089001531	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1075089001532	EamA-like transporter family; Region: EamA; pfam00892
1075089001533	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1075089001534	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1075089001535	inhibitor-cofactor binding pocket; inhibition site
1075089001536	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1075089001537	catalytic residue [active]
1075089001538	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
1075089001539	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1075089001540	Mg++ binding site [ion binding]; other site
1075089001541	putative catalytic motif [active]
1075089001542	substrate binding site [chemical binding]; other site
1075089001543	Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765
1075089001544	Predicted membrane protein [Function unknown]; Region: COG2431
1075089001545	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
1075089001546	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
1075089001547	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
1075089001548	putative active site [active]
1075089001549	putative metal-binding site [ion binding]; other site
1075089001550	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1075089001551	active site
1075089001552	DNA polymerase IV; Validated; Region: PRK02406
1075089001553	DNA binding site [nucleotide binding]
1075089001554	heat shock protein HtpX; Provisional; Region: PRK05457
1075089001555	Protein of unknown function, DUF462; Region: DUF462; cl01190
1075089001556	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
1075089001557	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1075089001558	Walker A/P-loop; other site
1075089001559	ATP binding site [chemical binding]; other site
1075089001560	Q-loop/lid; other site
1075089001561	ABC transporter signature motif; other site
1075089001562	Walker B; other site
1075089001563	D-loop; other site
1075089001564	H-loop/switch region; other site
1075089001565	inner membrane transport permease; Provisional; Region: PRK15066
1075089001566	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1075089001567	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
1075089001568	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1075089001569	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
1075089001570	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
1075089001571	Domain of unknown function (DUF3394); Region: DUF3394; pfam11874
1075089001572	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1075089001573	Ligand Binding Site [chemical binding]; other site
1075089001574	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1075089001575	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
1075089001576	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
1075089001577	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
1075089001578	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
1075089001579	Zn-ribbon-containing, possibly nucleic-acid-binding protein [General function prediction only]; Region: COG5595
1075089001580	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098
1075089001581	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1075089001582	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
1075089001583	probable active site [active]
1075089001584	Uncharacterized protein family (UPF0181); Region: UPF0181; pfam03701
1075089001585	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
1075089001586	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
1075089001587	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1075089001588	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
1075089001589	active site 1 [active]
1075089001590	dimer interface [polypeptide binding]; other site
1075089001591	active site 2 [active]
1075089001592	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1075089001593	putative deacylase active site [active]
1075089001594	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06901
1075089001595	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1075089001596	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1075089001597	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1075089001598	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1075089001599	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
1075089001600	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1075089001601	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1075089001602	putative active site [active]
1075089001603	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1075089001604	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
1075089001605	Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922
1075089001606	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
1075089001607	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1075089001608	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1075089001609	active site
1075089001610	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1075089001611	GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; Region: GT2_AmsE_like; cd04195
1075089001612	lytic murein transglycosylase; Region: MltB_2; TIGR02283
1075089001613	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1075089001614	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1075089001615	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1075089001616	Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553
1075089001617	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
1075089001618	Part of AAA domain; Region: AAA_19; pfam13245
1075089001619	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1075089001620	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
1075089001621	AAA domain; Region: AAA_30; pfam13604
1075089001622	Family description; Region: UvrD_C_2; pfam13538
1075089001623	Glutaredoxin 2 [Posttranslational modification, protein turnover, chaperones]; Region: GrxB; COG2999
1075089001624	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
1075089001625	C-terminal domain interface [polypeptide binding]; other site
1075089001626	GSH binding site (G-site) [chemical binding]; other site
1075089001627	catalytic residues [active]
1075089001628	putative dimer interface [polypeptide binding]; other site
1075089001629	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
1075089001630	N-terminal domain interface [polypeptide binding]; other site
1075089001631	Uncharacterized conserved protein [Function unknown]; Region: COG3422
1075089001632	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
1075089001633	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1075089001634	23S rRNA interface [nucleotide binding]; other site
1075089001635	L3 interface [polypeptide binding]; other site
1075089001636	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1075089001637	stringent starvation protein A; Provisional; Region: sspA; PRK09481
1075089001638	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
1075089001639	C-terminal domain interface [polypeptide binding]; other site
1075089001640	putative GSH binding site (G-site) [chemical binding]; other site
1075089001641	dimer interface [polypeptide binding]; other site
1075089001642	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
1075089001643	dimer interface [polypeptide binding]; other site
1075089001644	N-terminal domain interface [polypeptide binding]; other site
1075089001645	Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969
1075089001646	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
1075089001647	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1075089001648	active site
1075089001649	motif I; other site
1075089001650	motif II; other site
1075089001651	KpsF/GutQ family protein; Region: kpsF; TIGR00393
1075089001652	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1075089001653	putative active site [active]
1075089001654	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1075089001655	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
1075089001656	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1075089001657	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
1075089001658	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1075089001659	active site
1075089001660	HIGH motif; other site
1075089001661	nucleotide binding site [chemical binding]; other site
1075089001662	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
1075089001663	KMSKS motif; other site
1075089001664	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
1075089001665	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1075089001666	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
1075089001667	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1075089001668	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1075089001669	Coenzyme A binding pocket [chemical binding]; other site
1075089001670	hypothetical protein; Provisional; Region: PRK06762
1075089001671	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1075089001672	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1075089001673	TPP-binding site; other site
1075089001674	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1075089001675	PYR/PP interface [polypeptide binding]; other site
1075089001676	dimer interface [polypeptide binding]; other site
1075089001677	TPP binding site [chemical binding]; other site
1075089001678	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1075089001679	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1075089001680	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1075089001681	substrate binding pocket [chemical binding]; other site
1075089001682	chain length determination region; other site
1075089001683	substrate-Mg2+ binding site; other site
1075089001684	catalytic residues [active]
1075089001685	aspartate-rich region 1; other site
1075089001686	active site lid residues [active]
1075089001687	aspartate-rich region 2; other site
1075089001688	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1075089001689	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
1075089001690	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
1075089001691	molybdopterin cofactor binding site [chemical binding]; other site
1075089001692	substrate binding site [chemical binding]; other site
1075089001693	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
1075089001694	molybdopterin cofactor binding site; other site
1075089001695	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
1075089001696	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
1075089001697	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
1075089001698	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1075089001699	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1075089001700	Ligand Binding Site [chemical binding]; other site
1075089001701	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1075089001702	active site residue [active]
1075089001703	dsDNA-mimic protein; Reviewed; Region: PRK05094
1075089001704	TMAO/DMSO reductase; Reviewed; Region: PRK05363
1075089001705	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1075089001706	Moco binding site; other site
1075089001707	metal coordination site [ion binding]; other site
1075089001708	Predicted membrane protein [Function unknown]; Region: COG2717
1075089001709	hypothetical protein; Provisional; Region: PRK05170
1075089001710	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
1075089001711	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
1075089001712	glycogen branching enzyme; Provisional; Region: PRK05402
1075089001713	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1075089001714	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1075089001715	active site
1075089001716	catalytic site [active]
1075089001717	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1075089001718	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
1075089001719	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1075089001720	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1075089001721	active site
1075089001722	catalytic site [active]
1075089001723	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
1075089001724	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1075089001725	ligand binding site; other site
1075089001726	oligomer interface; other site
1075089001727	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1075089001728	N-terminal domain interface [polypeptide binding]; other site
1075089001729	sulfate 1 binding site; other site
1075089001730	glycogen synthase; Provisional; Region: glgA; PRK00654
1075089001731	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1075089001732	ADP-binding pocket [chemical binding]; other site
1075089001733	homodimer interface [polypeptide binding]; other site
1075089001734	glycogen phosphorylase; Provisional; Region: PRK14986
1075089001735	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1075089001736	homodimer interface [polypeptide binding]; other site
1075089001737	active site pocket [active]
1075089001738	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
1075089001739	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
1075089001740	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
1075089001741	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1075089001742	DNA binding site [nucleotide binding]
1075089001743	domain linker motif; other site
1075089001744	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
1075089001745	dimerization interface [polypeptide binding]; other site
1075089001746	ligand binding site [chemical binding]; other site
1075089001747	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1075089001748	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1075089001749	NAD(P) binding site [chemical binding]; other site
1075089001750	active site
1075089001751	arginine repressor; Provisional; Region: PRK05066
1075089001752	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1075089001753	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1075089001754	malate dehydrogenase; Provisional; Region: PRK05086
1075089001755	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
1075089001756	NAD binding site [chemical binding]; other site
1075089001757	dimerization interface [polypeptide binding]; other site
1075089001758	Substrate binding site [chemical binding]; other site
1075089001759	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
1075089001760	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1075089001761	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1075089001762	active site
1075089001763	HIGH motif; other site
1075089001764	KMSK motif region; other site
1075089001765	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1075089001766	tRNA binding surface [nucleotide binding]; other site
1075089001767	anticodon binding site; other site
1075089001768	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
1075089001769	putative metal binding site [ion binding]; other site
1075089001770	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
1075089001771	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1075089001772	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1075089001773	RF-1 domain; Region: RF-1; pfam00472
1075089001774	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1075089001775	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1075089001776	Uncharacterized conserved protein [Function unknown]; Region: COG2912
1075089001777	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
1075089001778	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
1075089001779	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1075089001780	glycerate dehydrogenase; Provisional; Region: PRK06932
1075089001781	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
1075089001782	putative ligand binding site [chemical binding]; other site
1075089001783	putative NAD binding site [chemical binding]; other site
1075089001784	catalytic site [active]
1075089001785	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
1075089001786	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1075089001787	FtsX-like permease family; Region: FtsX; pfam02687
1075089001788	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
1075089001789	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1075089001790	Walker A/P-loop; other site
1075089001791	ATP binding site [chemical binding]; other site
1075089001792	Q-loop/lid; other site
1075089001793	ABC transporter signature motif; other site
1075089001794	Walker B; other site
1075089001795	D-loop; other site
1075089001796	H-loop/switch region; other site
1075089001797	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
1075089001798	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1075089001799	FtsX-like permease family; Region: FtsX; pfam02687
1075089001800	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722
1075089001801	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1075089001802	cytosine deaminase; Provisional; Region: PRK09230
1075089001803	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1075089001804	active site
1075089001805	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1075089001806	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1075089001807	homodimer interface [polypeptide binding]; other site
1075089001808	substrate-cofactor binding pocket; other site
1075089001809	catalytic residue [active]
1075089001810	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1075089001811	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1075089001812	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1075089001813	dimerization interface [polypeptide binding]; other site
1075089001814	substrate binding pocket [chemical binding]; other site
1075089001815	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
1075089001816	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
1075089001817	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1075089001818	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1075089001819	dinuclear metal binding motif [ion binding]; other site
1075089001820	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
1075089001821	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1075089001822	active site
1075089001823	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1075089001824	catalytic triad [active]
1075089001825	dimer interface [polypeptide binding]; other site
1075089001826	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
1075089001827	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1075089001828	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1075089001829	Walker A/P-loop; other site
1075089001830	ATP binding site [chemical binding]; other site
1075089001831	Q-loop/lid; other site
1075089001832	ABC transporter signature motif; other site
1075089001833	Walker B; other site
1075089001834	D-loop; other site
1075089001835	H-loop/switch region; other site
1075089001836	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
1075089001837	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1075089001838	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1075089001839	Walker A/P-loop; other site
1075089001840	ATP binding site [chemical binding]; other site
1075089001841	Q-loop/lid; other site
1075089001842	ABC transporter signature motif; other site
1075089001843	Walker B; other site
1075089001844	D-loop; other site
1075089001845	H-loop/switch region; other site
1075089001846	thioredoxin reductase; Provisional; Region: PRK10262
1075089001847	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1075089001848	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1075089001849	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1075089001850	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
1075089001851	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
1075089001852	active site clefts [active]
1075089001853	zinc binding site [ion binding]; other site
1075089001854	dimer interface [polypeptide binding]; other site
1075089001855	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
1075089001856	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1075089001857	N-terminal plug; other site
1075089001858	ligand-binding site [chemical binding]; other site
1075089001859	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1075089001860	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1075089001861	substrate binding site [chemical binding]; other site
1075089001862	active site
1075089001863	catalytic residues [active]
1075089001864	heterodimer interface [polypeptide binding]; other site
1075089001865	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1075089001866	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1075089001867	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1075089001868	catalytic residue [active]
1075089001869	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
1075089001870	malonic semialdehyde reductase; Provisional; Region: PRK10538
1075089001871	putative NAD(P) binding site [chemical binding]; other site
1075089001872	homotetramer interface [polypeptide binding]; other site
1075089001873	homodimer interface [polypeptide binding]; other site
1075089001874	active site
1075089001875	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
1075089001876	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1075089001877	active site
1075089001878	ribulose/triose binding site [chemical binding]; other site
1075089001879	phosphate binding site [ion binding]; other site
1075089001880	substrate (anthranilate) binding pocket [chemical binding]; other site
1075089001881	product (indole) binding pocket [chemical binding]; other site
1075089001882	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1075089001883	active site
1075089001884	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1075089001885	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1075089001886	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1075089001887	Membrane transport protein; Region: Mem_trans; cl09117
1075089001888	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1075089001889	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1075089001890	glutamine binding [chemical binding]; other site
1075089001891	catalytic triad [active]
1075089001892	anthranilate synthase component I; Provisional; Region: PRK13564
1075089001893	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1075089001894	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1075089001895	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
1075089001896	putative inner membrane peptidase; Provisional; Region: PRK11778
1075089001897	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1075089001898	tandem repeat interface [polypeptide binding]; other site
1075089001899	oligomer interface [polypeptide binding]; other site
1075089001900	active site residues [active]
1075089001901	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
1075089001902	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
1075089001903	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1075089001904	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1075089001905	ligand binding site [chemical binding]; other site
1075089001906	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3001
1075089001907	Phosphotransferase enzyme family; Region: APH; pfam01636
1075089001908	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1075089001909	Na binding site [ion binding]; other site
1075089001910	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
1075089001911	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
1075089001912	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
1075089001913	Glutamate binding site [chemical binding]; other site
1075089001914	NAD binding site [chemical binding]; other site
1075089001915	catalytic residues [active]
1075089001916	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1075089001917	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1075089001918	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1075089001919	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1075089001920	peptide binding site [polypeptide binding]; other site
1075089001921	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1075089001922	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1075089001923	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
1075089001924	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1075089001925	active site
1075089001926	dimer interface [polypeptide binding]; other site
1075089001927	motif 1; other site
1075089001928	motif 2; other site
1075089001929	motif 3; other site
1075089001930	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1075089001931	anticodon binding site; other site
1075089001932	Predicted permeases [General function prediction only]; Region: COG0730
1075089001933	putative transporter; Provisional; Region: PRK10484
1075089001934	uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328
1075089001935	Na binding site [ion binding]; other site
1075089001936	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1075089001937	Sulfatase; Region: Sulfatase; cl17466
1075089001938	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1075089001939	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1075089001940	ligand binding site [chemical binding]; other site
1075089001941	flexible hinge region; other site
1075089001942	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
1075089001943	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1075089001944	FeS/SAM binding site; other site
1075089001945	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1075089001946	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
1075089001947	active site
1075089001948	phosphate binding residues; other site
1075089001949	catalytic residues [active]
1075089001950	translation initiation factor IF-3; Region: infC; TIGR00168
1075089001951	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1075089001952	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1075089001953	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1075089001954	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1075089001955	23S rRNA binding site [nucleotide binding]; other site
1075089001956	L21 binding site [polypeptide binding]; other site
1075089001957	L13 binding site [polypeptide binding]; other site
1075089001958	YadA-like C-terminal region; Region: YadA; pfam03895
1075089001959	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1075089001960	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
1075089001961	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
1075089001962	Ligand Binding Site [chemical binding]; other site
1075089001963	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukF; COG3006
1075089001964	condesin subunit E; Provisional; Region: PRK05256
1075089001965	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
1075089001966	P-loop containing region of AAA domain; Region: AAA_29; cl17516
1075089001967	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
1075089001968	exonuclease I; Provisional; Region: sbcB; PRK11779
1075089001969	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
1075089001970	active site
1075089001971	catalytic site [active]
1075089001972	substrate binding site [chemical binding]; other site
1075089001973	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
1075089001974	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
1075089001975	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1075089001976	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1075089001977	active site
1075089001978	interdomain interaction site; other site
1075089001979	putative metal-binding site [ion binding]; other site
1075089001980	nucleotide binding site [chemical binding]; other site
1075089001981	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1075089001982	domain I; other site
1075089001983	DNA binding groove [nucleotide binding]
1075089001984	phosphate binding site [ion binding]; other site
1075089001985	domain II; other site
1075089001986	domain III; other site
1075089001987	nucleotide binding site [chemical binding]; other site
1075089001988	catalytic site [active]
1075089001989	domain IV; other site
1075089001990	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1075089001991	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1075089001992	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
1075089001993	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
1075089001994	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
1075089001995	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1075089001996	active site
1075089001997	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1075089001998	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1075089001999	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1075089002000	quinone interaction residues [chemical binding]; other site
1075089002001	active site
1075089002002	catalytic residues [active]
1075089002003	FMN binding site [chemical binding]; other site
1075089002004	substrate binding site [chemical binding]; other site
1075089002005	aminopeptidase N; Provisional; Region: pepN; PRK14015
1075089002006	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
1075089002007	active site
1075089002008	Zn binding site [ion binding]; other site
1075089002009	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1075089002010	Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026
1075089002011	CUT domain; Region: CUT; pfam02376
1075089002012	ATP-grasp domain; Region: ATP-grasp; pfam02222
1075089002013	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
1075089002014	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1075089002015	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1075089002016	homodimer interface [polypeptide binding]; other site
1075089002017	catalytic residue [active]
1075089002018	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1075089002019	MoaE homodimer interface [polypeptide binding]; other site
1075089002020	MoaD interaction [polypeptide binding]; other site
1075089002021	active site residues [active]
1075089002022	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1075089002023	MoaE interaction surface [polypeptide binding]; other site
1075089002024	MoeB interaction surface [polypeptide binding]; other site
1075089002025	thiocarboxylated glycine; other site
1075089002026	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1075089002027	trimer interface [polypeptide binding]; other site
1075089002028	dimer interface [polypeptide binding]; other site
1075089002029	putative active site [active]
1075089002030	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1075089002031	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1075089002032	FeS/SAM binding site; other site
1075089002033	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1075089002034	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
1075089002035	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1075089002036	phosphate binding site [ion binding]; other site
1075089002037	putative substrate binding pocket [chemical binding]; other site
1075089002038	dimer interface [polypeptide binding]; other site
1075089002039	NlpC/P60 family; Region: NLPC_P60; pfam00877
1075089002040	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1075089002041	IHF dimer interface [polypeptide binding]; other site
1075089002042	IHF - DNA interface [nucleotide binding]; other site
1075089002043	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1075089002044	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1075089002045	putative tRNA-binding site [nucleotide binding]; other site
1075089002046	B3/4 domain; Region: B3_4; pfam03483
1075089002047	tRNA synthetase B5 domain; Region: B5; smart00874
1075089002048	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1075089002049	dimer interface [polypeptide binding]; other site
1075089002050	motif 1; other site
1075089002051	motif 3; other site
1075089002052	motif 2; other site
1075089002053	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
1075089002054	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1075089002055	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1075089002056	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1075089002057	dimer interface [polypeptide binding]; other site
1075089002058	motif 1; other site
1075089002059	active site
1075089002060	motif 2; other site
1075089002061	motif 3; other site
1075089002062	Uncharacterized conserved protein [Function unknown]; Region: COG4283
1075089002063	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1075089002064	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1075089002065	active site
1075089002066	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1075089002067	catalytic core [active]
1075089002068	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
1075089002069	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1075089002070	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1075089002071	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1075089002072	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1075089002073	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1075089002074	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1075089002075	dimerization interface 3.5A [polypeptide binding]; other site
1075089002076	active site
1075089002077	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
1075089002078	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
1075089002079	active site
1075089002080	nucleophile elbow; other site
1075089002081	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1075089002082	5S rRNA interface [nucleotide binding]; other site
1075089002083	CTC domain interface [polypeptide binding]; other site
1075089002084	L16 interface [polypeptide binding]; other site
1075089002085	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1075089002086	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1075089002087	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1075089002088	AAA domain; Region: AAA_26; pfam13500
1075089002089	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1075089002090	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1075089002091	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
1075089002092	putative dimer interface [polypeptide binding]; other site
1075089002093	putative anticodon binding site; other site
1075089002094	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1075089002095	homodimer interface [polypeptide binding]; other site
1075089002096	motif 1; other site
1075089002097	motif 2; other site
1075089002098	active site
1075089002099	motif 3; other site
1075089002100	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
1075089002101	Transglycosylase; Region: Transgly; pfam00912
1075089002102	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1075089002103	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
1075089002104	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
1075089002105	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1075089002106	putative SAM binding site [chemical binding]; other site
1075089002107	putative homodimer interface [polypeptide binding]; other site
1075089002108	LppC putative lipoprotein; Region: LppC; pfam04348
1075089002109	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
1075089002110	putative ligand binding site [chemical binding]; other site
1075089002111	hypothetical protein; Reviewed; Region: PRK12497
1075089002112	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1075089002113	dimer interface [polypeptide binding]; other site
1075089002114	active site
1075089002115	outer membrane lipoprotein; Provisional; Region: PRK11023
1075089002116	BON domain; Region: BON; pfam04972
1075089002117	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
1075089002118	Lumazine binding domain; Region: Lum_binding; pfam00677
1075089002119	Lumazine binding domain; Region: Lum_binding; pfam00677
1075089002120	multidrug efflux protein; Reviewed; Region: PRK01766
1075089002121	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1075089002122	cation binding site [ion binding]; other site
1075089002123	putative oxidoreductase; Provisional; Region: PRK11579
1075089002124	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1075089002125	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1075089002126	pyruvate kinase; Provisional; Region: PRK05826
1075089002127	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1075089002128	domain interfaces; other site
1075089002129	active site
1075089002130	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1075089002131	DNA-binding site [nucleotide binding]; DNA binding site
1075089002132	RNA-binding motif; other site
1075089002133	tellurite resistance protein TehB; Provisional; Region: PRK12335
1075089002134	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
1075089002135	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089002136	S-adenosylmethionine binding site [chemical binding]; other site
1075089002137	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
1075089002138	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1075089002139	trimer interface [polypeptide binding]; other site
1075089002140	active site
1075089002141	substrate binding site [chemical binding]; other site
1075089002142	CoA binding site [chemical binding]; other site
1075089002143	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506
1075089002144	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
1075089002145	MG2 domain; Region: A2M_N; pfam01835
1075089002146	Alpha-2-macroglobulin family; Region: A2M; pfam00207
1075089002147	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
1075089002148	surface patch; other site
1075089002149	thioester region; other site
1075089002150	specificity defining residues; other site
1075089002151	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
1075089002152	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1075089002153	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
1075089002154	substrate binding site [chemical binding]; other site
1075089002155	dimerization interface [polypeptide binding]; other site
1075089002156	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
1075089002157	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1075089002158	RNA binding surface [nucleotide binding]; other site
1075089002159	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
1075089002160	probable active site [active]
1075089002161	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1075089002162	Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409
1075089002163	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
1075089002164	catalytic site [active]
1075089002165	Asp-box motif; other site
1075089002166	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
1075089002167	Chorismate mutase type II; Region: CM_2; cl00693
1075089002168	prephenate dehydrogenase; Validated; Region: PRK08507
1075089002169	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
1075089002170	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1075089002171	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1075089002172	Ferritin-like domain; Region: Ferritin; pfam00210
1075089002173	ferroxidase diiron center [ion binding]; other site
1075089002174	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1075089002175	Ferritin-like domain; Region: Ferritin; pfam00210
1075089002176	ferroxidase diiron center [ion binding]; other site
1075089002177	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
1075089002178	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1075089002179	ligand binding site [chemical binding]; other site
1075089002180	flexible hinge region; other site
1075089002181	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1075089002182	putative switch regulator; other site
1075089002183	non-specific DNA interactions [nucleotide binding]; other site
1075089002184	DNA binding site [nucleotide binding]
1075089002185	sequence specific DNA binding site [nucleotide binding]; other site
1075089002186	putative cAMP binding site [chemical binding]; other site
1075089002187	universal stress protein UspE; Provisional; Region: PRK11175
1075089002188	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1075089002189	Ligand Binding Site [chemical binding]; other site
1075089002190	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1075089002191	Ligand Binding Site [chemical binding]; other site
1075089002192	Soluble cytochrome b562 [Energy production and conversion]; Region: CybC; COG3783
1075089002193	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
1075089002194	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
1075089002195	tandem repeat interface [polypeptide binding]; other site
1075089002196	oligomer interface [polypeptide binding]; other site
1075089002197	active site residues [active]
1075089002198	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1075089002199	tandem repeat interface [polypeptide binding]; other site
1075089002200	oligomer interface [polypeptide binding]; other site
1075089002201	active site residues [active]
1075089002202	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1075089002203	putative FMN binding site [chemical binding]; other site
1075089002204	RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248
1075089002205	ATP binding site [chemical binding]; other site
1075089002206	fructokinase; Reviewed; Region: PRK09557
1075089002207	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1075089002208	nucleotide binding site [chemical binding]; other site
1075089002209	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1075089002210	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1075089002211	active site
1075089002212	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1075089002213	dimerization interface [polypeptide binding]; other site
1075089002214	active site
1075089002215	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1075089002216	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1075089002217	peptide binding site [polypeptide binding]; other site
1075089002218	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
1075089002219	oligopeptidase A; Provisional; Region: PRK10911
1075089002220	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1075089002221	active site
1075089002222	Zn binding site [ion binding]; other site
1075089002223	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
1075089002224	MarR family; Region: MarR_2; cl17246
1075089002225	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1075089002226	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1075089002227	nucleotide binding site [chemical binding]; other site
1075089002228	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1075089002229	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1075089002230	tRNA; other site
1075089002231	putative tRNA binding site [nucleotide binding]; other site
1075089002232	putative NADP binding site [chemical binding]; other site
1075089002233	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1075089002234	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1075089002235	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089002236	uncharacterized domain; Region: TIGR00702
1075089002237	YcaO-like family; Region: YcaO; pfam02624
1075089002238	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
1075089002239	Protein of unknown function (DUF1043); Region: DUF1043; pfam06295
1075089002240	TIGR01619 family protein; Region: hyp_HI0040
1075089002241	Family of unknown function (DUF695); Region: DUF695; pfam05117
1075089002242	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1075089002243	putative catalytic site [active]
1075089002244	putative phosphate binding site [ion binding]; other site
1075089002245	active site
1075089002246	metal binding site A [ion binding]; metal-binding site
1075089002247	DNA binding site [nucleotide binding]
1075089002248	putative AP binding site [nucleotide binding]; other site
1075089002249	putative metal binding site B [ion binding]; other site
1075089002250	acetyl-CoA synthetase; Provisional; Region: PRK00174
1075089002251	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1075089002252	active site
1075089002253	CoA binding site [chemical binding]; other site
1075089002254	acyl-activating enzyme (AAE) consensus motif; other site
1075089002255	AMP binding site [chemical binding]; other site
1075089002256	acetate binding site [chemical binding]; other site
1075089002257	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1075089002258	homodecamer interface [polypeptide binding]; other site
1075089002259	GTP cyclohydrolase I; Provisional; Region: PLN03044
1075089002260	active site
1075089002261	putative catalytic site residues [active]
1075089002262	zinc binding site [ion binding]; other site
1075089002263	GTP-CH-I/GFRP interaction surface; other site
1075089002264	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
1075089002265	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1075089002266	dimer interface [polypeptide binding]; other site
1075089002267	putative functional site; other site
1075089002268	putative MPT binding site; other site
1075089002269	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
1075089002270	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1075089002271	ATP binding site [chemical binding]; other site
1075089002272	substrate interface [chemical binding]; other site
1075089002273	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
1075089002274	Flavoprotein; Region: Flavoprotein; pfam02441
1075089002275	amidophosphoribosyltransferase; Provisional; Region: PRK09246
1075089002276	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1075089002277	active site
1075089002278	tetramer interface [polypeptide binding]; other site
1075089002279	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1075089002280	active site
1075089002281	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1075089002282	Colicin V production protein; Region: Colicin_V; cl00567
1075089002283	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3092
1075089002284	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1075089002285	propionate/acetate kinase; Provisional; Region: PRK12379
1075089002286	phosphate acetyltransferase; Reviewed; Region: PRK05632
1075089002287	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1075089002288	DRTGG domain; Region: DRTGG; pfam07085
1075089002289	phosphate acetyltransferase; Region: pta; TIGR00651
1075089002290	ribonuclease D; Provisional; Region: PRK10829
1075089002291	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1075089002292	catalytic site [active]
1075089002293	putative active site [active]
1075089002294	putative substrate binding site [chemical binding]; other site
1075089002295	HRDC domain; Region: HRDC; pfam00570
1075089002296	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
1075089002297	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1075089002298	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1075089002299	acyl-activating enzyme (AAE) consensus motif; other site
1075089002300	putative AMP binding site [chemical binding]; other site
1075089002301	putative active site [active]
1075089002302	putative CoA binding site [chemical binding]; other site
1075089002303	Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065
1075089002304	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1075089002305	Glycoprotease family; Region: Peptidase_M22; pfam00814
1075089002306	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1075089002307	DEAD_2; Region: DEAD_2; pfam06733
1075089002308	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1075089002309	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
1075089002310	active site
1075089002311	phosphate binding residues; other site
1075089002312	catalytic residues [active]
1075089002313	Predicted permeases [General function prediction only]; Region: COG0679
1075089002314	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
1075089002315	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1075089002316	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1075089002317	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1075089002318	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
1075089002319	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1075089002320	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
1075089002321	ATP cone domain; Region: ATP-cone; pfam03477
1075089002322	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1075089002323	active site
1075089002324	dimer interface [polypeptide binding]; other site
1075089002325	catalytic residues [active]
1075089002326	effector binding site; other site
1075089002327	R2 peptide binding site; other site
1075089002328	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
1075089002329	Na2 binding site [ion binding]; other site
1075089002330	putative substrate binding site 1 [chemical binding]; other site
1075089002331	Na binding site 1 [ion binding]; other site
1075089002332	putative substrate binding site 2 [chemical binding]; other site
1075089002333	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1075089002334	dimer interface [polypeptide binding]; other site
1075089002335	putative radical transfer pathway; other site
1075089002336	diiron center [ion binding]; other site
1075089002337	tyrosyl radical; other site
1075089002338	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1075089002339	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1075089002340	catalytic loop [active]
1075089002341	iron binding site [ion binding]; other site
1075089002342	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1075089002343	The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758
1075089002344	putative molybdopterin cofactor binding site [chemical binding]; other site
1075089002345	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
1075089002346	putative molybdopterin cofactor binding site; other site
1075089002347	Cupin; Region: Cupin_6; pfam12852
1075089002348	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1075089002349	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1075089002350	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1075089002351	active site residue [active]
1075089002352	Predicted membrane protein [Function unknown]; Region: COG3059
1075089002353	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
1075089002354	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1075089002355	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1075089002356	LysE type translocator; Region: LysE; cl00565
1075089002357	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1075089002358	tetramer interfaces [polypeptide binding]; other site
1075089002359	binuclear metal-binding site [ion binding]; other site
1075089002360	Thiamine monophosphate kinase [Coenzyme metabolism]; Region: ThiL; COG0611
1075089002361	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1075089002362	ATP binding site [chemical binding]; other site
1075089002363	dimerization interface [polypeptide binding]; other site
1075089002364	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
1075089002365	putative RNA binding site [nucleotide binding]; other site
1075089002366	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1075089002367	homopentamer interface [polypeptide binding]; other site
1075089002368	active site
1075089002369	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1075089002370	aromatic amino acid transport protein; Region: araaP; TIGR00837
1075089002371	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1075089002372	dimer interface [polypeptide binding]; other site
1075089002373	FMN binding site [chemical binding]; other site
1075089002374	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1075089002375	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1075089002376	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1075089002377	protein binding site [polypeptide binding]; other site
1075089002378	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1075089002379	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
1075089002380	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
1075089002381	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1075089002382	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1075089002383	nucleotide binding site [chemical binding]; other site
1075089002384	photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042
1075089002385	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1075089002386	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
1075089002387	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1075089002388	homodimer interface [polypeptide binding]; other site
1075089002389	substrate-cofactor binding pocket; other site
1075089002390	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1075089002391	catalytic residue [active]
1075089002392	chaperone protein DnaJ; Provisional; Region: PRK10767
1075089002393	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1075089002394	HSP70 interaction site [polypeptide binding]; other site
1075089002395	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1075089002396	substrate binding site [polypeptide binding]; other site
1075089002397	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1075089002398	Zn binding sites [ion binding]; other site
1075089002399	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1075089002400	dimer interface [polypeptide binding]; other site
1075089002401	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
1075089002402	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1075089002403	N-terminal plug; other site
1075089002404	ligand-binding site [chemical binding]; other site
1075089002405	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
1075089002406	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1075089002407	Walker A/P-loop; other site
1075089002408	ATP binding site [chemical binding]; other site
1075089002409	Q-loop/lid; other site
1075089002410	ABC transporter signature motif; other site
1075089002411	Walker B; other site
1075089002412	D-loop; other site
1075089002413	H-loop/switch region; other site
1075089002414	TOBE domain; Region: TOBE; pfam03459
1075089002415	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1075089002416	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089002417	dimer interface [polypeptide binding]; other site
1075089002418	conserved gate region; other site
1075089002419	putative PBP binding loops; other site
1075089002420	ABC-ATPase subunit interface; other site
1075089002421	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
1075089002422	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1075089002423	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
1075089002424	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
1075089002425	molybdenum-pterin binding domain; Region: Mop; TIGR00638
1075089002426	TOBE domain; Region: TOBE; pfam03459
1075089002427	5'-nucleotidase; Provisional; Region: PRK03826
1075089002428	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
1075089002429	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1075089002430	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1075089002431	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
1075089002432	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1075089002433	catalytic motif [active]
1075089002434	Zn binding site [ion binding]; other site
1075089002435	RibD C-terminal domain; Region: RibD_C; cl17279
1075089002436	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1075089002437	ATP cone domain; Region: ATP-cone; pfam03477
1075089002438	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
1075089002439	putative active site [active]
1075089002440	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
1075089002441	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1075089002442	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
1075089002443	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1075089002444	ligand binding site [chemical binding]; other site
1075089002445	homodimer interface [polypeptide binding]; other site
1075089002446	NAD(P) binding site [chemical binding]; other site
1075089002447	trimer interface B [polypeptide binding]; other site
1075089002448	trimer interface A [polypeptide binding]; other site
1075089002449	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1075089002450	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
1075089002451	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1075089002452	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1075089002453	active site
1075089002454	HIGH motif; other site
1075089002455	dimer interface [polypeptide binding]; other site
1075089002456	KMSKS motif; other site
1075089002457	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1075089002458	RNA binding surface [nucleotide binding]; other site
1075089002459	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
1075089002460	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1075089002461	RNA binding site [nucleotide binding]; other site
1075089002462	active site
1075089002463	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
1075089002464	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1075089002465	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
1075089002466	translation initiation factor IF-2; Region: IF-2; TIGR00487
1075089002467	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1075089002468	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1075089002469	G1 box; other site
1075089002470	putative GEF interaction site [polypeptide binding]; other site
1075089002471	GTP/Mg2+ binding site [chemical binding]; other site
1075089002472	Switch I region; other site
1075089002473	G2 box; other site
1075089002474	G3 box; other site
1075089002475	Switch II region; other site
1075089002476	G4 box; other site
1075089002477	G5 box; other site
1075089002478	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1075089002479	Translation-initiation factor 2; Region: IF-2; pfam11987
1075089002480	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1075089002481	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
1075089002482	NusA N-terminal domain; Region: NusA_N; pfam08529
1075089002483	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1075089002484	RNA binding site [nucleotide binding]; other site
1075089002485	homodimer interface [polypeptide binding]; other site
1075089002486	NusA-like KH domain; Region: KH_5; pfam13184
1075089002487	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1075089002488	G-X-X-G motif; other site
1075089002489	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1075089002490	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1075089002491	Sm and related proteins; Region: Sm_like; cl00259
1075089002492	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
1075089002493	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1075089002494	putative oligomer interface [polypeptide binding]; other site
1075089002495	putative RNA binding site [nucleotide binding]; other site
1075089002496	transcriptional repressor UlaR; Provisional; Region: PRK13509
1075089002497	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1075089002498	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1075089002499	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
1075089002500	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1075089002501	PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548
1075089002502	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037
1075089002503	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1075089002504	active site
1075089002505	phosphorylation site [posttranslational modification]
1075089002506	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1075089002507	active site
1075089002508	dimer interface [polypeptide binding]; other site
1075089002509	magnesium binding site [ion binding]; other site
1075089002510	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1075089002511	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1075089002512	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
1075089002513	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1075089002514	ATP binding site [chemical binding]; other site
1075089002515	putative Mg++ binding site [ion binding]; other site
1075089002516	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1075089002517	nucleotide binding region [chemical binding]; other site
1075089002518	ATP-binding site [chemical binding]; other site
1075089002519	Helicase associated domain (HA2); Region: HA2; pfam04408
1075089002520	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
1075089002521	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
1075089002522	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
1075089002523	Predicted membrane protein [Function unknown]; Region: COG2707
1075089002524	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
1075089002525	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
1075089002526	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563
1075089002527	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1075089002528	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1075089002529	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1075089002530	active site
1075089002531	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1075089002532	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1075089002533	active site
1075089002534	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1075089002535	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1075089002536	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1075089002537	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1075089002538	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1075089002539	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1075089002540	active site
1075089002541	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
1075089002542	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1075089002543	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524
1075089002544	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1075089002545	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1075089002546	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1075089002547	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1075089002548	Walker A/P-loop; other site
1075089002549	ATP binding site [chemical binding]; other site
1075089002550	Q-loop/lid; other site
1075089002551	ABC transporter signature motif; other site
1075089002552	Walker B; other site
1075089002553	D-loop; other site
1075089002554	H-loop/switch region; other site
1075089002555	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
1075089002556	putative GSH binding site [chemical binding]; other site
1075089002557	catalytic residues [active]
1075089002558	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
1075089002559	Repair protein; Region: Repair_PSII; pfam04536
1075089002560	Predicted membrane protein [Function unknown]; Region: COG3762
1075089002561	LemA family; Region: LemA; pfam04011
1075089002562	outer membrane protein A; Reviewed; Region: PRK10808
1075089002563	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
1075089002564	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1075089002565	ligand binding site [chemical binding]; other site
1075089002566	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1075089002567	FAD binding domain; Region: FAD_binding_4; pfam01565
1075089002568	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1075089002569	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1075089002570	CoenzymeA binding site [chemical binding]; other site
1075089002571	subunit interaction site [polypeptide binding]; other site
1075089002572	PHB binding site; other site
1075089002573	ferrochelatase; Reviewed; Region: hemH; PRK00035
1075089002574	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1075089002575	C-terminal domain interface [polypeptide binding]; other site
1075089002576	active site
1075089002577	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1075089002578	active site
1075089002579	N-terminal domain interface [polypeptide binding]; other site
1075089002580	selenophosphate synthetase; Provisional; Region: PRK00943
1075089002581	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
1075089002582	dimerization interface [polypeptide binding]; other site
1075089002583	putative ATP binding site [chemical binding]; other site
1075089002584	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1075089002585	Shikimate kinase; Region: SKI; pfam01202
1075089002586	ATP-binding site [chemical binding]; other site
1075089002587	Gluconate-6-phosphate binding site [chemical binding]; other site
1075089002588	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1075089002589	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1075089002590	putative ligand binding site [chemical binding]; other site
1075089002591	putative dimerization interface [polypeptide binding]; other site
1075089002592	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
1075089002593	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
1075089002594	putative NAD(P) binding site [chemical binding]; other site
1075089002595	catalytic Zn binding site [ion binding]; other site
1075089002596	gluconate 5-dehydrogenase; Provisional; Region: PRK08085
1075089002597	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1075089002598	NADP binding site [chemical binding]; other site
1075089002599	homodimer interface [polypeptide binding]; other site
1075089002600	active site
1075089002601	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1075089002602	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
1075089002603	DctM-like transporters; Region: DctM; pfam06808
1075089002604	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1075089002605	cystathionine beta-lyase; Provisional; Region: PRK08114
1075089002606	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1075089002607	homodimer interface [polypeptide binding]; other site
1075089002608	substrate-cofactor binding pocket; other site
1075089002609	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1075089002610	catalytic residue [active]
1075089002611	peroxidase; Provisional; Region: PRK15000
1075089002612	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1075089002613	dimer interface [polypeptide binding]; other site
1075089002614	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1075089002615	catalytic triad [active]
1075089002616	peroxidatic and resolving cysteines [active]
1075089002617	translation initiation factor Sui1; Validated; Region: PRK06824
1075089002618	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
1075089002619	putative rRNA binding site [nucleotide binding]; other site
1075089002620	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1075089002621	active site
1075089002622	dimer interface [polypeptide binding]; other site
1075089002623	Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956
1075089002624	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
1075089002625	iron binding site [ion binding]; other site
1075089002626	Predicted membrane protein [Function unknown]; Region: COG3771
1075089002627	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1075089002628	IHF dimer interface [polypeptide binding]; other site
1075089002629	IHF - DNA interface [nucleotide binding]; other site
1075089002630	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
1075089002631	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1075089002632	RNA binding site [nucleotide binding]; other site
1075089002633	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1075089002634	RNA binding site [nucleotide binding]; other site
1075089002635	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1075089002636	RNA binding site [nucleotide binding]; other site
1075089002637	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
1075089002638	RNA binding site [nucleotide binding]; other site
1075089002639	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1075089002640	RNA binding site [nucleotide binding]; other site
1075089002641	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1075089002642	RNA binding site [nucleotide binding]; other site
1075089002643	cytidylate kinase; Provisional; Region: cmk; PRK00023
1075089002644	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1075089002645	CMP-binding site; other site
1075089002646	The sites determining sugar specificity; other site
1075089002647	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1075089002648	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
1075089002649	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1075089002650	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1075089002651	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1075089002652	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1075089002653	ornithine decarboxylase; Provisional; Region: PRK13578
1075089002654	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
1075089002655	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1075089002656	homodimer interface [polypeptide binding]; other site
1075089002657	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1075089002658	catalytic residue [active]
1075089002659	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1075089002660	putrescine transporter; Provisional; Region: potE; PRK10655
1075089002661	ornithine carbamoyltransferase; Validated; Region: PRK02102
1075089002662	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1075089002663	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1075089002664	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
1075089002665	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1075089002666	aromatic amino acid transport protein; Region: araaP; TIGR00837
1075089002667	tyrosine phenol-lyase; Provisional; Region: PRK13237
1075089002668	Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617
1075089002669	substrate binding site [chemical binding]; other site
1075089002670	tetramer interface [polypeptide binding]; other site
1075089002671	catalytic residue [active]
1075089002672	argininosuccinate synthase; Validated; Region: PRK05370
1075089002673	argininosuccinate synthase; Provisional; Region: PRK13820
1075089002674	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
1075089002675	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1075089002676	putative NAD(P) binding site [chemical binding]; other site
1075089002677	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
1075089002678	ATP binding site [chemical binding]; other site
1075089002679	active site
1075089002680	substrate binding site [chemical binding]; other site
1075089002681	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1075089002682	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1075089002683	G1 box; other site
1075089002684	putative GEF interaction site [polypeptide binding]; other site
1075089002685	GTP/Mg2+ binding site [chemical binding]; other site
1075089002686	Switch I region; other site
1075089002687	G2 box; other site
1075089002688	G3 box; other site
1075089002689	Switch II region; other site
1075089002690	G4 box; other site
1075089002691	G5 box; other site
1075089002692	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1075089002693	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1075089002694	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1075089002695	dimerization interface [polypeptide binding]; other site
1075089002696	DPS ferroxidase diiron center [ion binding]; other site
1075089002697	ion pore; other site
1075089002698	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1075089002699	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1075089002700	HIGH motif; other site
1075089002701	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1075089002702	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1075089002703	active site
1075089002704	KMSKS motif; other site
1075089002705	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1075089002706	tRNA binding surface [nucleotide binding]; other site
1075089002707	anticodon binding site; other site
1075089002708	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1075089002709	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1075089002710	dimer interface [polypeptide binding]; other site
1075089002711	catalytic triad [active]
1075089002712	peroxidatic and resolving cysteines [active]
1075089002713	putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208
1075089002714	oligomer interface [polypeptide binding]; other site
1075089002715	DNA polymerase III subunit chi; Validated; Region: PRK05728
1075089002716	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1075089002717	Class II fumarases; Region: Fumarase_classII; cd01362
1075089002718	active site
1075089002719	tetramer interface [polypeptide binding]; other site
1075089002720	hypothetical protein; Provisional; Region: PRK04940
1075089002721	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
1075089002722	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1075089002723	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
1075089002724	GSH binding site [chemical binding]; other site
1075089002725	catalytic residues [active]
1075089002726	N-acetylglutamate synthase; Validated; Region: PRK05279
1075089002727	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
1075089002728	putative feedback inhibition sensing region; other site
1075089002729	putative nucleotide binding site [chemical binding]; other site
1075089002730	putative substrate binding site [chemical binding]; other site
1075089002731	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1075089002732	Coenzyme A binding pocket [chemical binding]; other site
1075089002733	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1075089002734	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
1075089002735	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1075089002736	Protein of unknown function (DUF986); Region: DUF986; cl01983
1075089002737	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1075089002738	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1075089002739	trimer interface [polypeptide binding]; other site
1075089002740	eyelet of channel; other site
1075089002741	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
1075089002742	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
1075089002743	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
1075089002744	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1075089002745	active pocket/dimerization site; other site
1075089002746	active site
1075089002747	phosphorylation site [posttranslational modification]
1075089002748	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1075089002749	active site
1075089002750	phosphorylation site [posttranslational modification]
1075089002751	benzoate transport; Region: 2A0115; TIGR00895
1075089002752	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1075089002753	putative substrate translocation pore; other site
1075089002754	hypothetical protein; Provisional; Region: PRK05423
1075089002755	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
1075089002756	homodimer interface [polypeptide binding]; other site
1075089002757	substrate-cofactor binding pocket; other site
1075089002758	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1075089002759	catalytic residue [active]
1075089002760	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
1075089002761	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1075089002762	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1075089002763	homodimer interface [polypeptide binding]; other site
1075089002764	catalytic residue [active]
1075089002765	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1075089002766	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1075089002767	hinge; other site
1075089002768	active site
1075089002769	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
1075089002770	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089002771	S-adenosylmethionine binding site [chemical binding]; other site
1075089002772	DNA gyrase subunit A; Validated; Region: PRK05560
1075089002773	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1075089002774	CAP-like domain; other site
1075089002775	active site
1075089002776	primary dimer interface [polypeptide binding]; other site
1075089002777	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1075089002778	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1075089002779	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1075089002780	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1075089002781	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1075089002782	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1075089002783	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3094
1075089002784	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1075089002785	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
1075089002786	TadE-like protein; Region: TadE; pfam07811
1075089002787	TadE-like protein; Region: TadE; pfam07811
1075089002788	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
1075089002789	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1075089002790	binding surface
1075089002791	TPR motif; other site
1075089002792	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
1075089002793	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1075089002794	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1075089002795	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1075089002796	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1075089002797	ATP binding site [chemical binding]; other site
1075089002798	Walker A motif; other site
1075089002799	hexamer interface [polypeptide binding]; other site
1075089002800	Walker B motif; other site
1075089002801	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
1075089002802	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
1075089002803	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
1075089002804	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
1075089002805	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1075089002806	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
1075089002807	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1075089002808	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1075089002809	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1075089002810	GIY-YIG motif/motif A; other site
1075089002811	active site
1075089002812	catalytic site [active]
1075089002813	putative DNA binding site [nucleotide binding]; other site
1075089002814	metal binding site [ion binding]; metal-binding site
1075089002815	UvrB/uvrC motif; Region: UVR; pfam02151
1075089002816	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1075089002817	Helix-hairpin-helix motif; Region: HHH; pfam00633
1075089002818	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1075089002819	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1075089002820	Ligand binding site; other site
1075089002821	oligomer interface; other site
1075089002822	Uncharacterized conserved protein [Function unknown]; Region: COG2835
1075089002823	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
1075089002824	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
1075089002825	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
1075089002826	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1075089002827	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1075089002828	Walker A/P-loop; other site
1075089002829	ATP binding site [chemical binding]; other site
1075089002830	Q-loop/lid; other site
1075089002831	ABC transporter signature motif; other site
1075089002832	Walker B; other site
1075089002833	D-loop; other site
1075089002834	H-loop/switch region; other site
1075089002835	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1075089002836	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
1075089002837	Competence protein; Region: Competence; pfam03772
1075089002838	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1075089002839	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
1075089002840	poly(A) polymerase; Region: pcnB; TIGR01942
1075089002841	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1075089002842	active site
1075089002843	NTP binding site [chemical binding]; other site
1075089002844	metal binding triad [ion binding]; metal-binding site
1075089002845	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1075089002846	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
1075089002847	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1075089002848	catalytic center binding site [active]
1075089002849	ATP binding site [chemical binding]; other site
1075089002850	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
1075089002851	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
1075089002852	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1075089002853	putative active site [active]
1075089002854	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
1075089002855	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1075089002856	DNA binding site [nucleotide binding]
1075089002857	domain linker motif; other site
1075089002858	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
1075089002859	dimerization interface [polypeptide binding]; other site
1075089002860	ligand binding site [chemical binding]; other site
1075089002861	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1075089002862	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1075089002863	putative valine binding site [chemical binding]; other site
1075089002864	dimer interface [polypeptide binding]; other site
1075089002865	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1075089002866	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06882
1075089002867	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1075089002868	PYR/PP interface [polypeptide binding]; other site
1075089002869	dimer interface [polypeptide binding]; other site
1075089002870	TPP binding site [chemical binding]; other site
1075089002871	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1075089002872	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1075089002873	TPP-binding site [chemical binding]; other site
1075089002874	dimer interface [polypeptide binding]; other site
1075089002875	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
1075089002876	DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916
1075089002877	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1075089002878	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1075089002879	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1075089002880	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1075089002881	putative active site [active]
1075089002882	putative substrate binding site [chemical binding]; other site
1075089002883	putative cosubstrate binding site; other site
1075089002884	catalytic site [active]
1075089002885	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1075089002886	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1075089002887	active site
1075089002888	dimer interface [polypeptide binding]; other site
1075089002889	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1075089002890	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1075089002891	active site
1075089002892	trimer interface [polypeptide binding]; other site
1075089002893	allosteric site; other site
1075089002894	active site lid [active]
1075089002895	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1075089002896	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1075089002897	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1075089002898	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1075089002899	active site turn [active]
1075089002900	phosphorylation site [posttranslational modification]
1075089002901	ABC transporter ATPase component; Reviewed; Region: PRK11147
1075089002902	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1075089002903	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1075089002904	ABC transporter; Region: ABC_tran_2; pfam12848
1075089002905	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1075089002906	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318
1075089002907	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1075089002908	Zn2+ binding site [ion binding]; other site
1075089002909	Mg2+ binding site [ion binding]; other site
1075089002910	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1075089002911	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1075089002912	hypothetical protein; Provisional; Region: PRK01821
1075089002913	Staphylococcal nuclease homologues; Region: SNc; smart00318
1075089002914	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1075089002915	Catalytic site; other site
1075089002916	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1075089002917	Aminotransferase class-V; Region: Aminotran_5; pfam00266
1075089002918	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1075089002919	catalytic residue [active]
1075089002920	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
1075089002921	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
1075089002922	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
1075089002923	putative ribose interaction site [chemical binding]; other site
1075089002924	putative ADP binding site [chemical binding]; other site
1075089002925	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
1075089002926	active site
1075089002927	nucleotide binding site [chemical binding]; other site
1075089002928	HIGH motif; other site
1075089002929	KMSKS motif; other site
1075089002930	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1075089002931	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1075089002932	putative acyl-acceptor binding pocket; other site
1075089002933	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
1075089002934	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1075089002935	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
1075089002936	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1075089002937	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1075089002938	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
1075089002939	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1075089002940	Walker A/P-loop; other site
1075089002941	ATP binding site [chemical binding]; other site
1075089002942	Q-loop/lid; other site
1075089002943	ABC transporter signature motif; other site
1075089002944	Walker B; other site
1075089002945	D-loop; other site
1075089002946	H-loop/switch region; other site
1075089002947	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1075089002948	Walker A/P-loop; other site
1075089002949	ATP binding site [chemical binding]; other site
1075089002950	Q-loop/lid; other site
1075089002951	ABC transporter signature motif; other site
1075089002952	Walker B; other site
1075089002953	D-loop; other site
1075089002954	H-loop/switch region; other site
1075089002955	serine/threonine transporter SstT; Provisional; Region: PRK13628
1075089002956	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1075089002957	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
1075089002958	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
1075089002959	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
1075089002960	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1075089002961	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1075089002962	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1075089002963	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
1075089002964	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1075089002965	E3 interaction surface; other site
1075089002966	lipoyl attachment site [posttranslational modification]; other site
1075089002967	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1075089002968	E3 interaction surface; other site
1075089002969	lipoyl attachment site [posttranslational modification]; other site
1075089002970	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1075089002971	E3 interaction surface; other site
1075089002972	lipoyl attachment site [posttranslational modification]; other site
1075089002973	e3 binding domain; Region: E3_binding; pfam02817
1075089002974	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1075089002975	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1075089002976	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1075089002977	dimer interface [polypeptide binding]; other site
1075089002978	TPP-binding site [chemical binding]; other site
1075089002979	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
1075089002980	PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439
1075089002981	HPr interaction site; other site
1075089002982	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1075089002983	active site
1075089002984	phosphorylation site [posttranslational modification]
1075089002985	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
1075089002986	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1075089002987	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1075089002988	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1075089002989	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1075089002990	dimerization domain swap beta strand [polypeptide binding]; other site
1075089002991	regulatory protein interface [polypeptide binding]; other site
1075089002992	active site
1075089002993	regulatory phosphorylation site [posttranslational modification]; other site
1075089002994	GTPase RsgA; Reviewed; Region: PRK12288
1075089002995	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1075089002996	RNA binding site [nucleotide binding]; other site
1075089002997	homodimer interface [polypeptide binding]; other site
1075089002998	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1075089002999	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1075089003000	GTP/Mg2+ binding site [chemical binding]; other site
1075089003001	G4 box; other site
1075089003002	G5 box; other site
1075089003003	G1 box; other site
1075089003004	Switch I region; other site
1075089003005	G2 box; other site
1075089003006	G3 box; other site
1075089003007	Switch II region; other site
1075089003008	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1075089003009	catalytic site [active]
1075089003010	putative active site [active]
1075089003011	putative substrate binding site [chemical binding]; other site
1075089003012	dimer interface [polypeptide binding]; other site
1075089003013	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
1075089003014	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1075089003015	active site
1075089003016	metal binding site [ion binding]; metal-binding site
1075089003017	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1075089003018	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1075089003019	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1075089003020	DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323
1075089003021	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1075089003022	ATP binding site [chemical binding]; other site
1075089003023	Mg2+ binding site [ion binding]; other site
1075089003024	G-X-G motif; other site
1075089003025	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
1075089003026	ATP binding site [chemical binding]; other site
1075089003027	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1075089003028	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1075089003029	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1075089003030	bacterial Hfq-like; Region: Hfq; cd01716
1075089003031	hexamer interface [polypeptide binding]; other site
1075089003032	Sm1 motif; other site
1075089003033	RNA binding site [nucleotide binding]; other site
1075089003034	Sm2 motif; other site
1075089003035	GTPase HflX; Provisional; Region: PRK11058
1075089003036	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1075089003037	HflX GTPase family; Region: HflX; cd01878
1075089003038	G1 box; other site
1075089003039	GTP/Mg2+ binding site [chemical binding]; other site
1075089003040	Switch I region; other site
1075089003041	G2 box; other site
1075089003042	G3 box; other site
1075089003043	Switch II region; other site
1075089003044	G4 box; other site
1075089003045	G5 box; other site
1075089003046	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
1075089003047	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1075089003048	Walker A motif; other site
1075089003049	ATP binding site [chemical binding]; other site
1075089003050	Walker B motif; other site
1075089003051	arginine finger; other site
1075089003052	Predicted membrane protein [Function unknown]; Region: COG3768
1075089003053	Domain of unknown function (DUF697); Region: DUF697; cl12064
1075089003054	Predicted ATPase [General function prediction only]; Region: COG3106
1075089003055	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1075089003056	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1075089003057	peptide binding site [polypeptide binding]; other site
1075089003058	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168
1075089003059	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089003060	dimer interface [polypeptide binding]; other site
1075089003061	conserved gate region; other site
1075089003062	putative PBP binding loops; other site
1075089003063	ABC-ATPase subunit interface; other site
1075089003064	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171
1075089003065	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1075089003066	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089003067	dimer interface [polypeptide binding]; other site
1075089003068	conserved gate region; other site
1075089003069	putative PBP binding loops; other site
1075089003070	ABC-ATPase subunit interface; other site
1075089003071	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170
1075089003072	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1075089003073	Walker A/P-loop; other site
1075089003074	ATP binding site [chemical binding]; other site
1075089003075	Q-loop/lid; other site
1075089003076	ABC transporter signature motif; other site
1075089003077	Walker B; other site
1075089003078	D-loop; other site
1075089003079	H-loop/switch region; other site
1075089003080	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1075089003081	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167
1075089003082	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1075089003083	Walker A/P-loop; other site
1075089003084	ATP binding site [chemical binding]; other site
1075089003085	Q-loop/lid; other site
1075089003086	ABC transporter signature motif; other site
1075089003087	Walker B; other site
1075089003088	D-loop; other site
1075089003089	H-loop/switch region; other site
1075089003090	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1075089003091	classical (c) SDRs; Region: SDR_c; cd05233
1075089003092	NAD(P) binding site [chemical binding]; other site
1075089003093	active site
1075089003094	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
1075089003095	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1075089003096	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1075089003097	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1075089003098	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1075089003099	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1075089003100	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1075089003101	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1075089003102	active site
1075089003103	GMP synthase; Reviewed; Region: guaA; PRK00074
1075089003104	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1075089003105	AMP/PPi binding site [chemical binding]; other site
1075089003106	candidate oxyanion hole; other site
1075089003107	catalytic triad [active]
1075089003108	potential glutamine specificity residues [chemical binding]; other site
1075089003109	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1075089003110	ATP Binding subdomain [chemical binding]; other site
1075089003111	Ligand Binding sites [chemical binding]; other site
1075089003112	Dimerization subdomain; other site
1075089003113	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604
1075089003114	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1075089003115	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1075089003116	pyridoxamine kinase; Validated; Region: PRK05756
1075089003117	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1075089003118	dimer interface [polypeptide binding]; other site
1075089003119	pyridoxal binding site [chemical binding]; other site
1075089003120	ATP binding site [chemical binding]; other site
1075089003121	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
1075089003122	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1075089003123	Ligand Binding Site [chemical binding]; other site
1075089003124	TilS substrate binding domain; Region: TilS; pfam09179
1075089003125	TilS substrate C-terminal domain; Region: TilS_C; smart00977
1075089003126	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
1075089003127	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1075089003128	phosphate binding site [ion binding]; other site
1075089003129	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1075089003130	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1075089003131	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1075089003132	NAD binding site [chemical binding]; other site
1075089003133	homodimer interface [polypeptide binding]; other site
1075089003134	active site
1075089003135	substrate binding site [chemical binding]; other site
1075089003136	muropeptide transporter; Reviewed; Region: ampG; PRK11902
1075089003137	AmpG-like permease; Region: 2A0125; TIGR00901
1075089003138	adenylate kinase; Reviewed; Region: adk; PRK00279
1075089003139	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1075089003140	AMP-binding site [chemical binding]; other site
1075089003141	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1075089003142	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1075089003143	CoA binding domain; Region: CoA_binding; smart00881
1075089003144	CoA-ligase; Region: Ligase_CoA; pfam00549
1075089003145	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1075089003146	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1075089003147	CoA-ligase; Region: Ligase_CoA; pfam00549
1075089003148	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1075089003149	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1075089003150	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1075089003151	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1075089003152	E3 interaction surface; other site
1075089003153	lipoyl attachment site [posttranslational modification]; other site
1075089003154	e3 binding domain; Region: E3_binding; pfam02817
1075089003155	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1075089003156	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1075089003157	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1075089003158	TPP-binding site [chemical binding]; other site
1075089003159	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1075089003160	dimer interface [polypeptide binding]; other site
1075089003161	PYR/PP interface [polypeptide binding]; other site
1075089003162	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1075089003163	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1075089003164	dimer interface [polypeptide binding]; other site
1075089003165	active site
1075089003166	citrylCoA binding site [chemical binding]; other site
1075089003167	NADH binding [chemical binding]; other site
1075089003168	cationic pore residues; other site
1075089003169	oxalacetate/citrate binding site [chemical binding]; other site
1075089003170	coenzyme A binding site [chemical binding]; other site
1075089003171	catalytic triad [active]
1075089003172	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1075089003173	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1075089003174	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1075089003175	DctM-like transporters; Region: DctM; pfam06808
1075089003176	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1075089003177	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1075089003178	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
1075089003179	Peptidase M15; Region: Peptidase_M15_3; cl01194
1075089003180	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
1075089003181	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1075089003182	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1075089003183	carboxy-terminal protease; Provisional; Region: PRK11186
1075089003184	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1075089003185	protein binding site [polypeptide binding]; other site
1075089003186	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1075089003187	Catalytic dyad [active]
1075089003188	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
1075089003189	ProP expression regulator; Provisional; Region: PRK04950
1075089003190	ProQ/FINO family; Region: ProQ; pfam04352
1075089003191	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
1075089003192	Transmembrane protein 55A; Region: Tmemb_55A; pfam09788
1075089003193	Paraquat-inducible protein A; Region: PqiA; pfam04403
1075089003194	Paraquat-inducible protein A; Region: PqiA; pfam04403
1075089003195	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
1075089003196	mce related protein; Region: MCE; pfam02470
1075089003197	mce related protein; Region: MCE; pfam02470
1075089003198	mce related protein; Region: MCE; pfam02470
1075089003199	mce related protein; Region: MCE; pfam02470
1075089003200	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
1075089003201	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1075089003202	metal binding site [ion binding]; metal-binding site
1075089003203	dimer interface [polypeptide binding]; other site
1075089003204	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
1075089003205	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1075089003206	Walker A/P-loop; other site
1075089003207	ATP binding site [chemical binding]; other site
1075089003208	Q-loop/lid; other site
1075089003209	ABC transporter signature motif; other site
1075089003210	Walker B; other site
1075089003211	D-loop; other site
1075089003212	H-loop/switch region; other site
1075089003213	TOBE domain; Region: TOBE_2; pfam08402
1075089003214	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1075089003215	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089003216	dimer interface [polypeptide binding]; other site
1075089003217	conserved gate region; other site
1075089003218	putative PBP binding loops; other site
1075089003219	ABC-ATPase subunit interface; other site
1075089003220	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1075089003221	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089003222	dimer interface [polypeptide binding]; other site
1075089003223	conserved gate region; other site
1075089003224	ABC-ATPase subunit interface; other site
1075089003225	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
1075089003226	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
1075089003227	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
1075089003228	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
1075089003229	cytidine deaminase; Provisional; Region: PRK09027
1075089003230	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1075089003231	active site
1075089003232	catalytic motif [active]
1075089003233	Zn binding site [ion binding]; other site
1075089003234	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1075089003235	active site
1075089003236	catalytic motif [active]
1075089003237	Zn binding site [ion binding]; other site
1075089003238	seryl-tRNA synthetase; Provisional; Region: PRK05431
1075089003239	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1075089003240	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1075089003241	dimer interface [polypeptide binding]; other site
1075089003242	active site
1075089003243	motif 1; other site
1075089003244	motif 2; other site
1075089003245	motif 3; other site
1075089003246	recombination factor protein RarA; Reviewed; Region: PRK13342
1075089003247	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1075089003248	Walker A motif; other site
1075089003249	ATP binding site [chemical binding]; other site
1075089003250	Walker B motif; other site
1075089003251	arginine finger; other site
1075089003252	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1075089003253	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
1075089003254	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
1075089003255	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1075089003256	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1075089003257	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1075089003258	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1075089003259	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
1075089003260	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1075089003261	putative DNA binding site [nucleotide binding]; other site
1075089003262	dimerization interface [polypeptide binding]; other site
1075089003263	putative Zn2+ binding site [ion binding]; other site
1075089003264	AsnC family; Region: AsnC_trans_reg; pfam01037
1075089003265	DNA repair protein RadA; Provisional; Region: PRK11823
1075089003266	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1075089003267	Walker A motif; other site
1075089003268	ATP binding site [chemical binding]; other site
1075089003269	Walker B motif; other site
1075089003270	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1075089003271	Uncharacterized conserved protein [Function unknown]; Region: COG3025
1075089003272	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
1075089003273	putative active site [active]
1075089003274	putative metal binding residues [ion binding]; other site
1075089003275	signature motif; other site
1075089003276	putative triphosphate binding site [ion binding]; other site
1075089003277	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1075089003278	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1075089003279	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1075089003280	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
1075089003281	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1075089003282	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
1075089003283	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1075089003284	active site
1075089003285	NTP binding site [chemical binding]; other site
1075089003286	metal binding triad [ion binding]; metal-binding site
1075089003287	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1075089003288	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1075089003289	Zn2+ binding site [ion binding]; other site
1075089003290	Mg2+ binding site [ion binding]; other site
1075089003291	Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017
1075089003292	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
1075089003293	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
1075089003294	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1075089003295	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1075089003296	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1075089003297	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1075089003298	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1075089003299	active site
1075089003300	putative peptidase; Provisional; Region: PRK11649
1075089003301	Peptidase family M23; Region: Peptidase_M23; pfam01551
1075089003302	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
1075089003303	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1075089003304	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1075089003305	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1075089003306	ABC-ATPase subunit  interface; other site
1075089003307	dimer interface [polypeptide binding]; other site
1075089003308	putative PBP binding regions; other site
1075089003309	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1075089003310	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1075089003311	Walker A/P-loop; other site
1075089003312	ATP binding site [chemical binding]; other site
1075089003313	Q-loop/lid; other site
1075089003314	ABC transporter signature motif; other site
1075089003315	Walker B; other site
1075089003316	D-loop; other site
1075089003317	H-loop/switch region; other site
1075089003318	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1075089003319	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
1075089003320	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1075089003321	Walker A/P-loop; other site
1075089003322	ATP binding site [chemical binding]; other site
1075089003323	Q-loop/lid; other site
1075089003324	ABC transporter signature motif; other site
1075089003325	Walker B; other site
1075089003326	D-loop; other site
1075089003327	H-loop/switch region; other site
1075089003328	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1075089003329	dipeptide transporter; Provisional; Region: PRK10913
1075089003330	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1075089003331	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089003332	dimer interface [polypeptide binding]; other site
1075089003333	conserved gate region; other site
1075089003334	putative PBP binding loops; other site
1075089003335	ABC-ATPase subunit interface; other site
1075089003336	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1075089003337	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089003338	dimer interface [polypeptide binding]; other site
1075089003339	conserved gate region; other site
1075089003340	putative PBP binding loops; other site
1075089003341	ABC-ATPase subunit interface; other site
1075089003342	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1075089003343	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1075089003344	peptide binding site [polypeptide binding]; other site
1075089003345	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1075089003346	FAD binding site [chemical binding]; other site
1075089003347	putative protease; Provisional; Region: PRK15452
1075089003348	Peptidase family U32; Region: Peptidase_U32; pfam01136
1075089003349	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1075089003350	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1075089003351	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1075089003352	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1075089003353	active site
1075089003354	motif I; other site
1075089003355	motif II; other site
1075089003356	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
1075089003357	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1075089003358	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1075089003359	tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449
1075089003360	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
1075089003361	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
1075089003362	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1075089003363	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1075089003364	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1075089003365	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1075089003366	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1075089003367	Protein export membrane protein; Region: SecD_SecF; pfam02355
1075089003368	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1075089003369	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1075089003370	dimer interface [polypeptide binding]; other site
1075089003371	active site
1075089003372	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1075089003373	folate binding site [chemical binding]; other site
1075089003374	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1075089003375	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1075089003376	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1075089003377	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1075089003378	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
1075089003379	Sulfatase; Region: Sulfatase; pfam00884
1075089003380	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1075089003381	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1075089003382	purine monophosphate binding site [chemical binding]; other site
1075089003383	dimer interface [polypeptide binding]; other site
1075089003384	putative catalytic residues [active]
1075089003385	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1075089003386	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1075089003387	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
1075089003388	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
1075089003389	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1075089003390	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
1075089003391	DsbD alpha interface [polypeptide binding]; other site
1075089003392	catalytic residues [active]
1075089003393	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1075089003394	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
1075089003395	two-component response regulator; Provisional; Region: PRK11173
1075089003396	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1075089003397	active site
1075089003398	phosphorylation site [posttranslational modification]
1075089003399	intermolecular recognition site; other site
1075089003400	dimerization interface [polypeptide binding]; other site
1075089003401	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1075089003402	DNA binding site [nucleotide binding]
1075089003403	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
1075089003404	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1075089003405	SmpB-tmRNA interface; other site
1075089003406	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
1075089003407	sensor protein QseC; Provisional; Region: PRK10337
1075089003408	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1075089003409	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1075089003410	dimer interface [polypeptide binding]; other site
1075089003411	phosphorylation site [posttranslational modification]
1075089003412	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1075089003413	ATP binding site [chemical binding]; other site
1075089003414	Mg2+ binding site [ion binding]; other site
1075089003415	G-X-G motif; other site
1075089003416	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
1075089003417	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1075089003418	active site
1075089003419	phosphorylation site [posttranslational modification]
1075089003420	intermolecular recognition site; other site
1075089003421	dimerization interface [polypeptide binding]; other site
1075089003422	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1075089003423	DNA binding site [nucleotide binding]
1075089003424	Predicted membrane protein [Function unknown]; Region: COG2259
1075089003425	Uncharacterized low-complexity protein [Function unknown]; Region: COG3767
1075089003426	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3220
1075089003427	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3219
1075089003428	RNA polymerase sigma factor; Provisional; Region: PRK12530
1075089003429	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1075089003430	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1075089003431	DNA binding residues [nucleotide binding]
1075089003432	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
1075089003433	DNA topoisomerase III; Provisional; Region: PRK07726
1075089003434	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1075089003435	active site
1075089003436	putative interdomain interaction site [polypeptide binding]; other site
1075089003437	putative metal-binding site [ion binding]; other site
1075089003438	putative nucleotide binding site [chemical binding]; other site
1075089003439	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
1075089003440	domain I; other site
1075089003441	phosphate binding site [ion binding]; other site
1075089003442	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1075089003443	domain II; other site
1075089003444	domain III; other site
1075089003445	nucleotide binding site [chemical binding]; other site
1075089003446	DNA binding groove [nucleotide binding]
1075089003447	catalytic site [active]
1075089003448	domain IV; other site
1075089003449	recombination protein RecR; Reviewed; Region: recR; PRK00076
1075089003450	RecR protein; Region: RecR; pfam02132
1075089003451	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1075089003452	putative active site [active]
1075089003453	putative metal-binding site [ion binding]; other site
1075089003454	tetramer interface [polypeptide binding]; other site
1075089003455	hypothetical protein; Validated; Region: PRK00153
1075089003456	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
1075089003457	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
1075089003458	substrate binding site [chemical binding]; other site
1075089003459	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
1075089003460	substrate binding site [chemical binding]; other site
1075089003461	ligand binding site [chemical binding]; other site
1075089003462	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1075089003463	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1075089003464	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1075089003465	poxB regulator PoxA; Provisional; Region: PRK09350
1075089003466	motif 1; other site
1075089003467	dimer interface [polypeptide binding]; other site
1075089003468	active site
1075089003469	motif 2; other site
1075089003470	motif 3; other site
1075089003471	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
1075089003472	L-aspartate oxidase; Provisional; Region: PRK06175
1075089003473	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1075089003474	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
1075089003475	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1075089003476	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
1075089003477	D-subunit interface [polypeptide binding]; other site
1075089003478	Iron-sulfur protein interface; other site
1075089003479	proximal quinone binding site [chemical binding]; other site
1075089003480	distal quinone binding site [chemical binding]; other site
1075089003481	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
1075089003482	Iron-sulfur protein interface; other site
1075089003483	proximal quinone binding site [chemical binding]; other site
1075089003484	C-subunit interface; other site
1075089003485	distal quinone binding site; other site
1075089003486	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
1075089003487	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1075089003488	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
1075089003489	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1075089003490	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1075089003491	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1075089003492	interface (dimer of trimers) [polypeptide binding]; other site
1075089003493	Substrate-binding/catalytic site; other site
1075089003494	Zn-binding sites [ion binding]; other site
1075089003495	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1075089003496	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1075089003497	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
1075089003498	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1075089003499	catalytic residues [active]
1075089003500	alpha helical domain; other site
1075089003501	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
1075089003502	DHH family; Region: DHH; pfam01368
1075089003503	DHHA1 domain; Region: DHHA1; pfam02272
1075089003504	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
1075089003505	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
1075089003506	dimerization domain [polypeptide binding]; other site
1075089003507	dimer interface [polypeptide binding]; other site
1075089003508	catalytic residues [active]
1075089003509	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1075089003510	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1075089003511	RF-1 domain; Region: RF-1; pfam00472
1075089003512	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1075089003513	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1075089003514	dimer interface [polypeptide binding]; other site
1075089003515	putative anticodon binding site; other site
1075089003516	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1075089003517	motif 1; other site
1075089003518	active site
1075089003519	motif 2; other site
1075089003520	motif 3; other site
1075089003521	Sialyltransferase PMO188; Region: PM0188; pfam11477
1075089003522	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
1075089003523	ligand binding site; other site
1075089003524	tetramer interface; other site
1075089003525	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1075089003526	Ligand Binding Site [chemical binding]; other site
1075089003527	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1075089003528	active site
1075089003529	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
1075089003530	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1075089003531	FeS/SAM binding site; other site
1075089003532	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1075089003533	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
1075089003534	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984
1075089003535	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1075089003536	NAD binding site [chemical binding]; other site
1075089003537	homotetramer interface [polypeptide binding]; other site
1075089003538	homodimer interface [polypeptide binding]; other site
1075089003539	substrate binding site [chemical binding]; other site
1075089003540	active site
1075089003541	exoribonuclease II; Provisional; Region: PRK05054
1075089003542	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1075089003543	RNB domain; Region: RNB; pfam00773
1075089003544	S1 RNA binding domain; Region: S1; pfam00575
1075089003545	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1075089003546	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1075089003547	hinge; other site
1075089003548	active site
1075089003549	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
1075089003550	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1075089003551	anti sigma factor interaction site; other site
1075089003552	regulatory phosphorylation site [posttranslational modification]; other site
1075089003553	ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; COG2854
1075089003554	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1075089003555	mce related protein; Region: MCE; pfam02470
1075089003556	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1075089003557	conserved hypothetical integral membrane protein; Region: TIGR00056
1075089003558	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
1075089003559	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1075089003560	Walker A/P-loop; other site
1075089003561	ATP binding site [chemical binding]; other site
1075089003562	Q-loop/lid; other site
1075089003563	ABC transporter signature motif; other site
1075089003564	Walker B; other site
1075089003565	D-loop; other site
1075089003566	H-loop/switch region; other site
1075089003567	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
1075089003568	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
1075089003569	OstA-like protein; Region: OstA; cl00844
1075089003570	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
1075089003571	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
1075089003572	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1075089003573	Walker A/P-loop; other site
1075089003574	ATP binding site [chemical binding]; other site
1075089003575	Q-loop/lid; other site
1075089003576	ABC transporter signature motif; other site
1075089003577	Walker B; other site
1075089003578	D-loop; other site
1075089003579	H-loop/switch region; other site
1075089003580	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1075089003581	active site
1075089003582	phosphorylation site [posttranslational modification]
1075089003583	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
1075089003584	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1075089003585	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1075089003586	generic binding surface II; other site
1075089003587	generic binding surface I; other site
1075089003588	Uncharacterized conserved protein [Function unknown]; Region: COG2850
1075089003589	hypothetical protein; Validated; Region: PRK01777
1075089003590	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
1075089003591	putative coenzyme Q binding site [chemical binding]; other site
1075089003592	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1075089003593	putative active site [active]
1075089003594	catalytic residue [active]
1075089003595	GTP-binding protein YchF; Reviewed; Region: PRK09601
1075089003596	YchF GTPase; Region: YchF; cd01900
1075089003597	G1 box; other site
1075089003598	GTP/Mg2+ binding site [chemical binding]; other site
1075089003599	Switch I region; other site
1075089003600	G2 box; other site
1075089003601	Switch II region; other site
1075089003602	G3 box; other site
1075089003603	G4 box; other site
1075089003604	G5 box; other site
1075089003605	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1075089003606	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
1075089003607	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1075089003608	dimer interface [polypeptide binding]; other site
1075089003609	FMN binding site [chemical binding]; other site
1075089003610	allantoate amidohydrolase; Reviewed; Region: PRK09290
1075089003611	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1075089003612	active site
1075089003613	metal binding site [ion binding]; metal-binding site
1075089003614	dimer interface [polypeptide binding]; other site
1075089003615	Predicted transcriptional regulator [General function prediction only]; Region: COG3054
1075089003616	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1075089003617	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1075089003618	PhnA protein; Region: PhnA; pfam03831
1075089003619	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
1075089003620	D-ribose pyranase; Provisional; Region: PRK11797
1075089003621	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
1075089003622	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1075089003623	Walker A/P-loop; other site
1075089003624	ATP binding site [chemical binding]; other site
1075089003625	Q-loop/lid; other site
1075089003626	ABC transporter signature motif; other site
1075089003627	Walker B; other site
1075089003628	D-loop; other site
1075089003629	H-loop/switch region; other site
1075089003630	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1075089003631	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1075089003632	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1075089003633	TM-ABC transporter signature motif; other site
1075089003634	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
1075089003635	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
1075089003636	ligand binding site [chemical binding]; other site
1075089003637	dimerization interface [polypeptide binding]; other site
1075089003638	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1075089003639	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1075089003640	substrate binding site [chemical binding]; other site
1075089003641	dimer interface [polypeptide binding]; other site
1075089003642	ATP binding site [chemical binding]; other site
1075089003643	transcriptional repressor RbsR; Provisional; Region: PRK10423
1075089003644	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1075089003645	DNA binding site [nucleotide binding]
1075089003646	domain linker motif; other site
1075089003647	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
1075089003648	dimerization interface [polypeptide binding]; other site
1075089003649	ligand binding site [chemical binding]; other site
1075089003650	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
1075089003651	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
1075089003652	Prephenate dehydratase; Region: PDT; pfam00800
1075089003653	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1075089003654	putative L-Phe binding site [chemical binding]; other site
1075089003655	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
1075089003656	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1075089003657	dimer interface [polypeptide binding]; other site
1075089003658	active site
1075089003659	metal binding site [ion binding]; metal-binding site
1075089003660	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
1075089003661	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
1075089003662	cell division protein FtsZ; Validated; Region: PRK09330
1075089003663	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1075089003664	nucleotide binding site [chemical binding]; other site
1075089003665	SulA interaction site; other site
1075089003666	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
1075089003667	Cell division protein FtsA; Region: FtsA; smart00842
1075089003668	Cell division protein FtsA; Region: FtsA; pfam14450
1075089003669	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1075089003670	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1075089003671	Cell division protein FtsQ; Region: FtsQ; pfam03799
1075089003672	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
1075089003673	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1075089003674	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1075089003675	UDP-N-acetylmuramate--alanine ligase; Region: murC; TIGR01082
1075089003676	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1075089003677	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1075089003678	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1075089003679	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1075089003680	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1075089003681	active site
1075089003682	homodimer interface [polypeptide binding]; other site
1075089003683	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
1075089003684	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
1075089003685	Putative NAD(P)-binding; Region: NAD_binding_7; cl17660
1075089003686	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1075089003687	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1075089003688	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1075089003689	Mg++ binding site [ion binding]; other site
1075089003690	putative catalytic motif [active]
1075089003691	putative substrate binding site [chemical binding]; other site
1075089003692	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
1075089003693	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1075089003694	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1075089003695	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1075089003696	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1075089003697	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1075089003698	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1075089003699	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1075089003700	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
1075089003701	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1075089003702	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1075089003703	Cell division protein [Cell division and chromosome partitioning]; Region: FtsL; COG3116
1075089003704	MraW methylase family; Region: Methyltransf_5; pfam01795
1075089003705	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1075089003706	cell division protein MraZ; Reviewed; Region: PRK00326
1075089003707	MraZ protein; Region: MraZ; pfam02381
1075089003708	MraZ protein; Region: MraZ; pfam02381
1075089003709	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
1075089003710	Carbon starvation protein CstA; Region: CstA; pfam02554
1075089003711	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1075089003712	iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411
1075089003713	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1075089003714	siderophore binding site; other site
1075089003715	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1075089003716	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1075089003717	ABC-ATPase subunit  interface; other site
1075089003718	dimer interface [polypeptide binding]; other site
1075089003719	putative PBP binding regions; other site
1075089003720	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1075089003721	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1075089003722	ABC-ATPase subunit  interface; other site
1075089003723	dimer interface [polypeptide binding]; other site
1075089003724	putative PBP binding regions; other site
1075089003725	iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231
1075089003726	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1075089003727	Walker A/P-loop; other site
1075089003728	ATP binding site [chemical binding]; other site
1075089003729	Q-loop/lid; other site
1075089003730	ABC transporter signature motif; other site
1075089003731	Walker B; other site
1075089003732	D-loop; other site
1075089003733	H-loop/switch region; other site
1075089003734	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
1075089003735	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089003736	dimer interface [polypeptide binding]; other site
1075089003737	conserved gate region; other site
1075089003738	putative PBP binding loops; other site
1075089003739	ABC-ATPase subunit interface; other site
1075089003740	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1075089003741	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089003742	dimer interface [polypeptide binding]; other site
1075089003743	conserved gate region; other site
1075089003744	putative PBP binding loops; other site
1075089003745	ABC-ATPase subunit interface; other site
1075089003746	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
1075089003747	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1075089003748	substrate binding pocket [chemical binding]; other site
1075089003749	membrane-bound complex binding site; other site
1075089003750	hinge residues; other site
1075089003751	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
1075089003752	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1075089003753	Walker A/P-loop; other site
1075089003754	ATP binding site [chemical binding]; other site
1075089003755	Q-loop/lid; other site
1075089003756	ABC transporter signature motif; other site
1075089003757	Walker B; other site
1075089003758	D-loop; other site
1075089003759	H-loop/switch region; other site
1075089003760	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1075089003761	dimer interface [polypeptide binding]; other site
1075089003762	active site
1075089003763	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1075089003764	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1075089003765	active site
1075089003766	peptidase PmbA; Provisional; Region: PRK11040
1075089003767	Protein of unknown function (DUF615); Region: DUF615; cl01147
1075089003768	FtsH protease regulator HflC; Provisional; Region: PRK11029
1075089003769	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
1075089003770	FtsH protease regulator HflK; Provisional; Region: PRK10930
1075089003771	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
1075089003772	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1075089003773	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1075089003774	threonine synthase; Validated; Region: PRK09225
1075089003775	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1075089003776	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1075089003777	catalytic residue [active]
1075089003778	homoserine kinase; Provisional; Region: PRK01212
1075089003779	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1075089003780	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1075089003781	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
1075089003782	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1075089003783	nucleotide binding site [chemical binding]; other site
1075089003784	substrate binding site [chemical binding]; other site
1075089003785	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
1075089003786	dimer interface [polypeptide binding]; other site
1075089003787	putative threonine allosteric regulatory site; other site
1075089003788	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
1075089003789	putative threonine allosteric regulatory site; other site
1075089003790	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1075089003791	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1075089003792	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
1075089003793	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1075089003794	catalytic residue [active]
1075089003795	Protein of unknown function (DUF3732); Region: DUF3732; pfam12532
1075089003796	SIR2-like domain; Region: SIR2_2; pfam13289
1075089003797	Domain of unknown function DUF87; Region: DUF87; pfam01935
1075089003798	HerA helicase [Replication, recombination, and repair]; Region: COG0433
1075089003799	Zonular occludens toxin (Zot); Region: Zot; cl17485
1075089003800	Uncharacterized conserved protein [Function unknown]; Region: COG1801
1075089003801	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1075089003802	RNA/DNA hybrid binding site [nucleotide binding]; other site
1075089003803	active site
1075089003804	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
1075089003805	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
1075089003806	active site
1075089003807	catalytic site [active]
1075089003808	substrate binding site [chemical binding]; other site
1075089003809	GTP-binding protein Der; Reviewed; Region: PRK00093
1075089003810	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1075089003811	G1 box; other site
1075089003812	GTP/Mg2+ binding site [chemical binding]; other site
1075089003813	Switch I region; other site
1075089003814	G2 box; other site
1075089003815	Switch II region; other site
1075089003816	G3 box; other site
1075089003817	G4 box; other site
1075089003818	G5 box; other site
1075089003819	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1075089003820	G1 box; other site
1075089003821	GTP/Mg2+ binding site [chemical binding]; other site
1075089003822	Switch I region; other site
1075089003823	G2 box; other site
1075089003824	G3 box; other site
1075089003825	Switch II region; other site
1075089003826	G4 box; other site
1075089003827	G5 box; other site
1075089003828	FtsI repressor; Provisional; Region: PRK10883
1075089003829	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1075089003830	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
1075089003831	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1075089003832	putative acyl-acceptor binding pocket; other site
1075089003833	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1075089003834	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1075089003835	putative active site [active]
1075089003836	putative metal binding site [ion binding]; other site
1075089003837	Uncharacterized integral membrane protein [Function unknown]; Region: COG5413
1075089003838	elongation factor P; Validated; Region: PRK00529
1075089003839	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1075089003840	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1075089003841	RNA binding site [nucleotide binding]; other site
1075089003842	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1075089003843	RNA binding site [nucleotide binding]; other site
1075089003844	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
1075089003845	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1075089003846	FeS/SAM binding site; other site
1075089003847	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
1075089003848	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
1075089003849	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1075089003850	DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974
1075089003851	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1075089003852	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1075089003853	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
1075089003854	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1075089003855	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1075089003856	active site
1075089003857	Int/Topo IB signature motif; other site
1075089003858	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1075089003859	30S subunit binding site; other site
1075089003860	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1075089003861	amino acid carrier protein; Region: agcS; TIGR00835
1075089003862	Predicted acetyltransferase [General function prediction only]; Region: COG2388
1075089003863	DNA gyrase inhibitor; Reviewed; Region: PRK00418
1075089003864	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1075089003865	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1075089003866	CoA-binding site [chemical binding]; other site
1075089003867	ATP-binding [chemical binding]; other site
1075089003868	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1075089003869	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1075089003870	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1075089003871	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1075089003872	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1075089003873	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
1075089003874	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
1075089003875	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1075089003876	Walker A motif; other site
1075089003877	ATP binding site [chemical binding]; other site
1075089003878	Walker B motif; other site
1075089003879	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
1075089003880	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1075089003881	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1075089003882	amidase catalytic site [active]
1075089003883	Zn binding residues [ion binding]; other site
1075089003884	substrate binding site [chemical binding]; other site
1075089003885	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
1075089003886	putative active site [active]
1075089003887	Ap4A binding site [chemical binding]; other site
1075089003888	nudix motif; other site
1075089003889	putative metal binding site [ion binding]; other site
1075089003890	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1075089003891	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1075089003892	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1075089003893	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1075089003894	dimerization interface [polypeptide binding]; other site
1075089003895	active site
1075089003896	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1075089003897	nucleoside/Zn binding site; other site
1075089003898	dimer interface [polypeptide binding]; other site
1075089003899	catalytic motif [active]
1075089003900	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
1075089003901	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1075089003902	FeS/SAM binding site; other site
1075089003903	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
1075089003904	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
1075089003905	active site
1075089003906	oxyanion hole [active]
1075089003907	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1075089003908	catalytic triad [active]
1075089003909	Autotransporter beta-domain; Region: Autotransporter; cl17461
1075089003910	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1075089003911	Pyruvate formate lyase 1; Region: PFL1; cd01678
1075089003912	coenzyme A binding site [chemical binding]; other site
1075089003913	active site
1075089003914	catalytic residues [active]
1075089003915	glycine loop; other site
1075089003916	formate transporter FocA; Region: formate_focA; TIGR04060
1075089003917	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
1075089003918	nucleotide binding site/active site [active]
1075089003919	HIT family signature motif; other site
1075089003920	catalytic residue [active]
1075089003921	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
1075089003922	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
1075089003923	putative dimer interface [polypeptide binding]; other site
1075089003924	beta-hexosaminidase; Provisional; Region: PRK05337
1075089003925	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1075089003926	23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522
1075089003927	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
1075089003928	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1075089003929	active site
1075089003930	ADP/pyrophosphate binding site [chemical binding]; other site
1075089003931	dimerization interface [polypeptide binding]; other site
1075089003932	allosteric effector site; other site
1075089003933	fructose-1,6-bisphosphate binding site; other site
1075089003934	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1075089003935	Cation efflux family; Region: Cation_efflux; cl00316
1075089003936	hypothetical protein; Validated; Region: PRK02101
1075089003937	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1075089003938	ligand binding site [chemical binding]; other site
1075089003939	active site
1075089003940	UGI interface [polypeptide binding]; other site
1075089003941	catalytic site [active]
1075089003942	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
1075089003943	GTP-binding protein LepA; Provisional; Region: PRK05433
1075089003944	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1075089003945	G1 box; other site
1075089003946	putative GEF interaction site [polypeptide binding]; other site
1075089003947	GTP/Mg2+ binding site [chemical binding]; other site
1075089003948	Switch I region; other site
1075089003949	G2 box; other site
1075089003950	G3 box; other site
1075089003951	Switch II region; other site
1075089003952	G4 box; other site
1075089003953	G5 box; other site
1075089003954	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1075089003955	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1075089003956	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1075089003957	signal peptidase I; Provisional; Region: PRK10861
1075089003958	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1075089003959	Catalytic site [active]
1075089003960	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1075089003961	ribonuclease III; Reviewed; Region: rnc; PRK00102
1075089003962	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1075089003963	dimerization interface [polypeptide binding]; other site
1075089003964	active site
1075089003965	metal binding site [ion binding]; metal-binding site
1075089003966	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1075089003967	dsRNA binding site [nucleotide binding]; other site
1075089003968	GTPase Era; Reviewed; Region: era; PRK00089
1075089003969	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1075089003970	G1 box; other site
1075089003971	GTP/Mg2+ binding site [chemical binding]; other site
1075089003972	Switch I region; other site
1075089003973	G2 box; other site
1075089003974	Switch II region; other site
1075089003975	G3 box; other site
1075089003976	G4 box; other site
1075089003977	G5 box; other site
1075089003978	KH domain; Region: KH_2; pfam07650
1075089003979	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1075089003980	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1075089003981	Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; pfam03543
1075089003982	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1075089003983	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1075089003984	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
1075089003985	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1075089003986	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1075089003987	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
1075089003988	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
1075089003989	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
1075089003990	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1075089003991	dimer interface [polypeptide binding]; other site
1075089003992	tetramer interface [polypeptide binding]; other site
1075089003993	PYR/PP interface [polypeptide binding]; other site
1075089003994	TPP binding site [chemical binding]; other site
1075089003995	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1075089003996	TPP-binding site; other site
1075089003997	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
1075089003998	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1075089003999	aminotransferase AlaT; Validated; Region: PRK09265
1075089004000	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1075089004001	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1075089004002	homodimer interface [polypeptide binding]; other site
1075089004003	catalytic residue [active]
1075089004004	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1075089004005	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1075089004006	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1075089004007	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089004008	dimer interface [polypeptide binding]; other site
1075089004009	conserved gate region; other site
1075089004010	putative PBP binding loops; other site
1075089004011	ABC-ATPase subunit interface; other site
1075089004012	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089004013	dimer interface [polypeptide binding]; other site
1075089004014	conserved gate region; other site
1075089004015	putative PBP binding loops; other site
1075089004016	ABC-ATPase subunit interface; other site
1075089004017	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1075089004018	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1075089004019	Walker A/P-loop; other site
1075089004020	ATP binding site [chemical binding]; other site
1075089004021	Q-loop/lid; other site
1075089004022	ABC transporter signature motif; other site
1075089004023	Walker B; other site
1075089004024	D-loop; other site
1075089004025	H-loop/switch region; other site
1075089004026	fatty acid metabolism regulator; Provisional; Region: PRK04984
1075089004027	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1075089004028	DNA-binding site [nucleotide binding]; DNA binding site
1075089004029	FadR C-terminal domain; Region: FadR_C; pfam07840
1075089004030	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
1075089004031	disulfide bond formation protein B; Provisional; Region: PRK01749
1075089004032	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
1075089004033	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1075089004034	substrate binding pocket [chemical binding]; other site
1075089004035	membrane-bound complex binding site; other site
1075089004036	hinge residues; other site
1075089004037	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1075089004038	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1075089004039	catalytic residue [active]
1075089004040	hypothetical protein; Provisional; Region: PRK11111
1075089004041	glutamate dehydrogenase; Provisional; Region: PRK09414
1075089004042	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1075089004043	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1075089004044	NAD(P) binding site [chemical binding]; other site
1075089004045	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
1075089004046	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1075089004047	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1075089004048	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
1075089004049	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
1075089004050	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1075089004051	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
1075089004052	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1075089004053	putative active site [active]
1075089004054	putative dimer interface [polypeptide binding]; other site
1075089004055	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1075089004056	serine transporter; Region: stp; TIGR00814
1075089004057	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1075089004058	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1075089004059	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1075089004060	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738
1075089004061	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1075089004062	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
1075089004063	putative active site [active]
1075089004064	putative PHP Thumb interface [polypeptide binding]; other site
1075089004065	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1075089004066	generic binding surface II; other site
1075089004067	generic binding surface I; other site
1075089004068	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1075089004069	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1075089004070	tetramer interface [polypeptide binding]; other site
1075089004071	heme binding pocket [chemical binding]; other site
1075089004072	NADPH binding site [chemical binding]; other site
1075089004073	Predicted flavoproteins [General function prediction only]; Region: COG2081
1075089004074	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1075089004075	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
1075089004076	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1075089004077	binding surface
1075089004078	TPR motif; other site
1075089004079	cytochrome c nitrite reductase, accessory protein NrfF; Region: cyt_nit_nrfF; TIGR03147
1075089004080	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
1075089004081	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
1075089004082	catalytic residues [active]
1075089004083	central insert; other site
1075089004084	cytochrome c nitrate reductase biogenesis protein NrfE; Region: cyt_nit_nrfE; TIGR03145
1075089004085	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
1075089004086	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
1075089004087	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
1075089004088	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
1075089004089	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
1075089004090	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
1075089004091	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1075089004092	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1075089004093	dimerization interface [polypeptide binding]; other site
1075089004094	putative ATP binding site [chemical binding]; other site
1075089004095	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1075089004096	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1075089004097	active site
1075089004098	substrate binding site [chemical binding]; other site
1075089004099	cosubstrate binding site; other site
1075089004100	catalytic site [active]
1075089004101	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1075089004102	active site
1075089004103	uracil-xanthine permease; Region: ncs2; TIGR00801
1075089004104	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
1075089004105	DNA replication initiation factor; Validated; Region: PRK06893
1075089004106	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
1075089004107	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1075089004108	putative metal binding site [ion binding]; other site
1075089004109	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
1075089004110	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
1075089004111	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1075089004112	TPR motif; other site
1075089004113	binding surface
1075089004114	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
1075089004115	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
1075089004116	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1075089004117	catalytic residues [active]
1075089004118	central insert; other site
1075089004119	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
1075089004120	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165
1075089004121	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
1075089004122	heme exporter protein CcmC; Region: ccmC; TIGR01191
1075089004123	heme exporter protein CcmB; Region: ccmB; TIGR01190
1075089004124	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
1075089004125	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1075089004126	Walker A/P-loop; other site
1075089004127	ATP binding site [chemical binding]; other site
1075089004128	Q-loop/lid; other site
1075089004129	ABC transporter signature motif; other site
1075089004130	Walker B; other site
1075089004131	D-loop; other site
1075089004132	H-loop/switch region; other site
1075089004133	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1075089004134	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
1075089004135	TrkA-N domain; Region: TrkA_N; pfam02254
1075089004136	Predicted flavoprotein [General function prediction only]; Region: COG0431
1075089004137	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1075089004138	Pirin-related protein [General function prediction only]; Region: COG1741
1075089004139	Pirin; Region: Pirin; pfam02678
1075089004140	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1075089004141	trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933
1075089004142	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1075089004143	Ca binding site [ion binding]; other site
1075089004144	active site
1075089004145	catalytic site [active]
1075089004146	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
1075089004147	PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007
1075089004148	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1075089004149	active site turn [active]
1075089004150	phosphorylation site [posttranslational modification]
1075089004151	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1075089004152	trehalose repressor; Provisional; Region: treR; PRK09492
1075089004153	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1075089004154	DNA binding site [nucleotide binding]
1075089004155	domain linker motif; other site
1075089004156	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
1075089004157	dimerization interface [polypeptide binding]; other site
1075089004158	ligand binding site [chemical binding]; other site
1075089004159	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1075089004160	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1075089004161	putative substrate translocation pore; other site
1075089004162	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
1075089004163	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1075089004164	RNA binding surface [nucleotide binding]; other site
1075089004165	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1075089004166	active site
1075089004167	uracil binding [chemical binding]; other site
1075089004168	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
1075089004169	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1075089004170	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1075089004171	putative NAD(P) binding site [chemical binding]; other site
1075089004172	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
1075089004173	superoxide dismutase; Provisional; Region: PRK10925
1075089004174	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1075089004175	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1075089004176	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
1075089004177	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1075089004178	active site
1075089004179	metal binding site [ion binding]; metal-binding site
1075089004180	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1075089004181	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1075089004182	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
1075089004183	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
1075089004184	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1075089004185	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1075089004186	dimer interface [polypeptide binding]; other site
1075089004187	motif 1; other site
1075089004188	active site
1075089004189	motif 2; other site
1075089004190	motif 3; other site
1075089004191	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1075089004192	anticodon binding site; other site
1075089004193	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1075089004194	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1075089004195	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1075089004196	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1075089004197	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1075089004198	non-specific DNA binding site [nucleotide binding]; other site
1075089004199	salt bridge; other site
1075089004200	sequence-specific DNA binding site [nucleotide binding]; other site
1075089004201	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1075089004202	TPR repeat; Region: TPR_11; pfam13414
1075089004203	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1075089004204	binding surface
1075089004205	TPR motif; other site
1075089004206	TPR repeat; Region: TPR_11; pfam13414
1075089004207	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
1075089004208	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1075089004209	FeS/SAM binding site; other site
1075089004210	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1075089004211	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1075089004212	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1075089004213	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1075089004214	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1075089004215	MPT binding site; other site
1075089004216	trimer interface [polypeptide binding]; other site
1075089004217	Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589
1075089004218	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1075089004219	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1075089004220	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1075089004221	putative acyl-acceptor binding pocket; other site
1075089004222	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1075089004223	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1075089004224	transmembrane helices; other site
1075089004225	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1075089004226	TrkA-C domain; Region: TrkA_C; pfam02080
1075089004227	TrkA-C domain; Region: TrkA_C; pfam02080
1075089004228	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1075089004229	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1075089004230	RNA/DNA hybrid binding site [nucleotide binding]; other site
1075089004231	active site
1075089004232	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
1075089004233	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1075089004234	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1075089004235	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1075089004236	active site
1075089004237	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1075089004238	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1075089004239	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1075089004240	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1075089004241	trimer interface [polypeptide binding]; other site
1075089004242	active site
1075089004243	UDP-GlcNAc binding site [chemical binding]; other site
1075089004244	lipid binding site [chemical binding]; lipid-binding site
1075089004245	periplasmic chaperone; Provisional; Region: PRK10780
1075089004246	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
1075089004247	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
1075089004248	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1075089004249	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1075089004250	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1075089004251	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1075089004252	Surface antigen; Region: Bac_surface_Ag; pfam01103
1075089004253	zinc metallopeptidase RseP; Provisional; Region: PRK10779
1075089004254	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1075089004255	active site
1075089004256	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1075089004257	protein binding site [polypeptide binding]; other site
1075089004258	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1075089004259	protein binding site [polypeptide binding]; other site
1075089004260	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1075089004261	putative substrate binding region [chemical binding]; other site
1075089004262	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
1075089004263	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1075089004264	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
1075089004265	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1075089004266	catalytic residue [active]
1075089004267	putative FPP diphosphate  binding site; other site
1075089004268	putative FPP binding hydrophobic cleft; other site
1075089004269	dimer interface [polypeptide binding]; other site
1075089004270	putative IPP diphosphate binding site; other site
1075089004271	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1075089004272	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1075089004273	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1075089004274	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1075089004275	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1075089004276	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1075089004277	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1075089004278	hinge region; other site
1075089004279	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1075089004280	putative nucleotide binding site [chemical binding]; other site
1075089004281	uridine monophosphate binding site [chemical binding]; other site
1075089004282	homohexameric interface [polypeptide binding]; other site
1075089004283	elongation factor Ts; Provisional; Region: tsf; PRK09377
1075089004284	UBA/TS-N domain; Region: UBA; pfam00627
1075089004285	Elongation factor TS; Region: EF_TS; pfam00889
1075089004286	Elongation factor TS; Region: EF_TS; pfam00889
1075089004287	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1075089004288	rRNA interaction site [nucleotide binding]; other site
1075089004289	S8 interaction site; other site
1075089004290	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
1075089004291	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1075089004292	HlyD family secretion protein; Region: HlyD_3; pfam13437
1075089004293	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1075089004294	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1075089004295	Walker A/P-loop; other site
1075089004296	ATP binding site [chemical binding]; other site
1075089004297	Q-loop/lid; other site
1075089004298	ABC transporter signature motif; other site
1075089004299	Walker B; other site
1075089004300	D-loop; other site
1075089004301	H-loop/switch region; other site
1075089004302	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1075089004303	Walker A/P-loop; other site
1075089004304	ATP binding site [chemical binding]; other site
1075089004305	Q-loop/lid; other site
1075089004306	ABC transporter signature motif; other site
1075089004307	Walker B; other site
1075089004308	D-loop; other site
1075089004309	H-loop/switch region; other site
1075089004310	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1075089004311	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1075089004312	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1075089004313	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1075089004314	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1075089004315	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1075089004316	periplasmic folding chaperone; Provisional; Region: PRK10788
1075089004317	SurA N-terminal domain; Region: SurA_N_3; cl07813
1075089004318	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1075089004319	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1075089004320	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1075089004321	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1075089004322	Walker A motif; other site
1075089004323	ATP binding site [chemical binding]; other site
1075089004324	Walker B motif; other site
1075089004325	arginine finger; other site
1075089004326	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1075089004327	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1075089004328	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1075089004329	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1075089004330	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1075089004331	Walker A motif; other site
1075089004332	ATP binding site [chemical binding]; other site
1075089004333	Walker B motif; other site
1075089004334	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1075089004335	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1075089004336	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1075089004337	oligomer interface [polypeptide binding]; other site
1075089004338	active site residues [active]
1075089004339	trigger factor; Provisional; Region: tig; PRK01490
1075089004340	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1075089004341	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1075089004342	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
1075089004343	BON domain; Region: BON; pfam04972
1075089004344	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1075089004345	Predicted metalloprotease [General function prediction only]; Region: COG2321
1075089004346	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1075089004347	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515
1075089004348	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
1075089004349	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
1075089004350	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
1075089004351	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516
1075089004352	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
1075089004353	Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322
1075089004354	putative NAD(P) binding site [chemical binding]; other site
1075089004355	active site
1075089004356	DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234
1075089004357	potential frameshift: common BLAST hit: gi|170717299|ref|YP_001784413.1| HAD family hydrolase
1075089004358	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
1075089004359	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1075089004360	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1075089004361	motif II; other site
1075089004362	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
1075089004363	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1075089004364	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1075089004365	2-isopropylmalate synthase; Validated; Region: PRK00915
1075089004366	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1075089004367	active site
1075089004368	catalytic residues [active]
1075089004369	metal binding site [ion binding]; metal-binding site
1075089004370	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
1075089004371	tartrate dehydrogenase; Region: TTC; TIGR02089
1075089004372	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1075089004373	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1075089004374	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1075089004375	substrate binding site [chemical binding]; other site
1075089004376	ligand binding site [chemical binding]; other site
1075089004377	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1075089004378	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1075089004379	substrate binding site [chemical binding]; other site
1075089004380	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787
1075089004381	rod shape-determining protein MreD; Region: MreD; cl01087
1075089004382	rod shape-determining protein MreC; Region: mreC; TIGR00219
1075089004383	rod shape-determining protein MreC; Region: MreC; pfam04085
1075089004384	rod shape-determining protein MreB; Provisional; Region: PRK13927
1075089004385	MreB and similar proteins; Region: MreB_like; cd10225
1075089004386	nucleotide binding site [chemical binding]; other site
1075089004387	Mg binding site [ion binding]; other site
1075089004388	putative protofilament interaction site [polypeptide binding]; other site
1075089004389	RodZ interaction site [polypeptide binding]; other site
1075089004390	exoribonuclease R; Provisional; Region: PRK11642
1075089004391	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
1075089004392	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1075089004393	RNB domain; Region: RNB; pfam00773
1075089004394	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1075089004395	RNA binding site [nucleotide binding]; other site
1075089004396	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
1075089004397	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1075089004398	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1075089004399	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1075089004400	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1075089004401	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1075089004402	ABC transporter signature motif; other site
1075089004403	Walker B; other site
1075089004404	D-loop; other site
1075089004405	H-loop/switch region; other site
1075089004406	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1075089004407	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1075089004408	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1075089004409	dimer interface [polypeptide binding]; other site
1075089004410	ssDNA binding site [nucleotide binding]; other site
1075089004411	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1075089004412	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1075089004413	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
1075089004414	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1075089004415	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1075089004416	homodimer interface [polypeptide binding]; other site
1075089004417	NADP binding site [chemical binding]; other site
1075089004418	substrate binding site [chemical binding]; other site
1075089004419	YadA-like C-terminal region; Region: YadA; pfam03895
1075089004420	Protein of unknown function, DUF417; Region: DUF417; cl01162
1075089004421	Lipoate synthase [Coenzyme metabolism]; Region: LipA; COG0320
1075089004422	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1075089004423	FeS/SAM binding site; other site
1075089004424	lipoate-protein ligase B; Provisional; Region: PRK14342
1075089004425	hypothetical protein; Provisional; Region: PRK04998
1075089004426	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
1075089004427	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1075089004428	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
1075089004429	rare lipoprotein A; Region: rlpA; TIGR00413
1075089004430	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1075089004431	Sporulation related domain; Region: SPOR; pfam05036
1075089004432	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
1075089004433	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1075089004434	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1075089004435	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1075089004436	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
1075089004437	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
1075089004438	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
1075089004439	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1075089004440	ATP binding site [chemical binding]; other site
1075089004441	Mg++ binding site [ion binding]; other site
1075089004442	motif III; other site
1075089004443	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1075089004444	nucleotide binding region [chemical binding]; other site
1075089004445	ATP-binding site [chemical binding]; other site
1075089004446	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1075089004447	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1075089004448	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1075089004449	RNA binding site [nucleotide binding]; other site
1075089004450	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1075089004451	multimer interface [polypeptide binding]; other site
1075089004452	Walker A motif; other site
1075089004453	ATP binding site [chemical binding]; other site
1075089004454	Walker B motif; other site
1075089004455	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714
1075089004456	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
1075089004457	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
1075089004458	acyl carrier protein; Provisional; Region: acpP; PRK00982
1075089004459	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1075089004460	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1075089004461	NAD(P) binding site [chemical binding]; other site
1075089004462	homotetramer interface [polypeptide binding]; other site
1075089004463	homodimer interface [polypeptide binding]; other site
1075089004464	active site
1075089004465	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1075089004466	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1075089004467	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1075089004468	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1075089004469	dimer interface [polypeptide binding]; other site
1075089004470	active site
1075089004471	CoA binding pocket [chemical binding]; other site
1075089004472	Fatty acid/phospholipid biosynthesis enzyme [Lipid metabolism]; Region: PlsX; COG0416
1075089004473	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
1075089004474	hypothetical protein; Provisional; Region: PRK11193
1075089004475	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
1075089004476	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1075089004477	peptide binding site [polypeptide binding]; other site
1075089004478	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
1075089004479	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089004480	dimer interface [polypeptide binding]; other site
1075089004481	conserved gate region; other site
1075089004482	putative PBP binding loops; other site
1075089004483	ABC-ATPase subunit interface; other site
1075089004484	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
1075089004485	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1075089004486	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089004487	dimer interface [polypeptide binding]; other site
1075089004488	conserved gate region; other site
1075089004489	ABC-ATPase subunit interface; other site
1075089004490	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
1075089004491	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1075089004492	Walker A/P-loop; other site
1075089004493	ATP binding site [chemical binding]; other site
1075089004494	Q-loop/lid; other site
1075089004495	ABC transporter signature motif; other site
1075089004496	Walker B; other site
1075089004497	D-loop; other site
1075089004498	H-loop/switch region; other site
1075089004499	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1075089004500	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
1075089004501	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1075089004502	Walker A/P-loop; other site
1075089004503	ATP binding site [chemical binding]; other site
1075089004504	Q-loop/lid; other site
1075089004505	ABC transporter signature motif; other site
1075089004506	Walker B; other site
1075089004507	D-loop; other site
1075089004508	H-loop/switch region; other site
1075089004509	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1075089004510	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
1075089004511	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
1075089004512	active site
1075089004513	zinc binding site [ion binding]; other site
1075089004514	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1075089004515	AAA domain; Region: AAA_26; pfam13500
1075089004516	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1075089004517	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089004518	S-adenosylmethionine binding site [chemical binding]; other site
1075089004519	Protein of unknown function (DUF452); Region: DUF452; pfam04301
1075089004520	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
1075089004521	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
1075089004522	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1075089004523	catalytic residue [active]
1075089004524	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173
1075089004525	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1075089004526	inhibitor-cofactor binding pocket; inhibition site
1075089004527	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1075089004528	catalytic residue [active]
1075089004529	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
1075089004530	gamma-glutamyl kinase; Provisional; Region: PRK05429
1075089004531	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1075089004532	nucleotide binding site [chemical binding]; other site
1075089004533	homotetrameric interface [polypeptide binding]; other site
1075089004534	putative phosphate binding site [ion binding]; other site
1075089004535	putative allosteric binding site; other site
1075089004536	PUA domain; Region: PUA; pfam01472
1075089004537	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1075089004538	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1075089004539	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
1075089004540	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1075089004541	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1075089004542	folate binding site [chemical binding]; other site
1075089004543	NADP+ binding site [chemical binding]; other site
1075089004544	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1075089004545	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1075089004546	metal-binding site [ion binding]
1075089004547	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1075089004548	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1075089004549	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1075089004550	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1075089004551	metal-binding site [ion binding]
1075089004552	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
1075089004553	hypothetical protein; Provisional; Region: PRK11212
1075089004554	two-component sensor protein; Provisional; Region: cpxA; PRK09470
1075089004555	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1075089004556	dimerization interface [polypeptide binding]; other site
1075089004557	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1075089004558	ATP binding site [chemical binding]; other site
1075089004559	Mg2+ binding site [ion binding]; other site
1075089004560	G-X-G motif; other site
1075089004561	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1075089004562	active site
1075089004563	phosphorylation site [posttranslational modification]
1075089004564	intermolecular recognition site; other site
1075089004565	dimerization interface [polypeptide binding]; other site
1075089004566	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1075089004567	DNA binding site [nucleotide binding]
1075089004568	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
1075089004569	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
1075089004570	Nucleoid-associated protein [General function prediction only]; Region: COG3081
1075089004571	nucleoid-associated protein NdpA; Validated; Region: PRK00378
1075089004572	hypothetical protein; Provisional; Region: PRK13689
1075089004573	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
1075089004574	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
1075089004575	Sulfatase; Region: Sulfatase; cl17466
1075089004576	hypothetical protein; Validated; Region: PRK06886
1075089004577	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1075089004578	active site
1075089004579	dUMP phosphatase; Provisional; Region: PRK09449
1075089004580	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1075089004581	motif II; other site
1075089004582	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
1075089004583	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1075089004584	FMN binding site [chemical binding]; other site
1075089004585	active site
1075089004586	catalytic residues [active]
1075089004587	substrate binding site [chemical binding]; other site
1075089004588	Predicted membrane protein [Function unknown]; Region: COG3647
1075089004589	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
1075089004590	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
1075089004591	putative metal binding site [ion binding]; other site
1075089004592	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1075089004593	HSP70 interaction site [polypeptide binding]; other site
1075089004594	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1075089004595	active site
1075089004596	ribonuclease PH; Reviewed; Region: rph; PRK00173
1075089004597	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1075089004598	hexamer interface [polypeptide binding]; other site
1075089004599	active site
1075089004600	hypothetical protein; Provisional; Region: PRK11820
1075089004601	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1075089004602	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1075089004603	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
1075089004604	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1075089004605	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1075089004606	CTP synthetase; Validated; Region: pyrG; PRK05380
1075089004607	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1075089004608	Catalytic site [active]
1075089004609	active site
1075089004610	UTP binding site [chemical binding]; other site
1075089004611	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1075089004612	active site
1075089004613	putative oxyanion hole; other site
1075089004614	catalytic triad [active]
1075089004615	enolase; Provisional; Region: eno; PRK00077
1075089004616	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1075089004617	dimer interface [polypeptide binding]; other site
1075089004618	metal binding site [ion binding]; metal-binding site
1075089004619	substrate binding pocket [chemical binding]; other site
1075089004620	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1075089004621	hypothetical protein; Validated; Region: PRK00228
1075089004622	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1075089004623	RNA methyltransferase, RsmE family; Region: TIGR00046
1075089004624	Recombination protein O N terminal; Region: RecO_N; pfam11967
1075089004625	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
1075089004626	Recombination protein O C terminal; Region: RecO_C; pfam02565
1075089004627	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
1075089004628	TRAM domain; Region: TRAM; pfam01938
1075089004629	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089004630	S-adenosylmethionine binding site [chemical binding]; other site
1075089004631	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
1075089004632	HD domain; Region: HD_4; pfam13328
1075089004633	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1075089004634	synthetase active site [active]
1075089004635	NTP binding site [chemical binding]; other site
1075089004636	metal binding site [ion binding]; metal-binding site
1075089004637	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1075089004638	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1075089004639	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1075089004640	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1075089004641	O-Antigen ligase; Region: Wzy_C; pfam04932
1075089004642	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1075089004643	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
1075089004644	active site
1075089004645	intersubunit interface [polypeptide binding]; other site
1075089004646	zinc binding site [ion binding]; other site
1075089004647	Na+ binding site [ion binding]; other site
1075089004648	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1075089004649	Phosphoglycerate kinase; Region: PGK; pfam00162
1075089004650	substrate binding site [chemical binding]; other site
1075089004651	hinge regions; other site
1075089004652	ADP binding site [chemical binding]; other site
1075089004653	catalytic site [active]
1075089004654	Ribonuclease I [Translation, ribosomal structure and biogenesis]; Region: Rna; COG3719
1075089004655	CAS motifs; other site
1075089004656	active site
1075089004657	ferredoxin; Validated; Region: PRK07118
1075089004658	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1075089004659	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1075089004660	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1075089004661	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
1075089004662	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
1075089004663	domain interface [polypeptide binding]; other site
1075089004664	putative active site [active]
1075089004665	catalytic site [active]
1075089004666	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
1075089004667	domain interface [polypeptide binding]; other site
1075089004668	putative active site [active]
1075089004669	catalytic site [active]
1075089004670	Uncharacterized conserved protein [Function unknown]; Region: COG1556
1075089004671	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
1075089004672	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1075089004673	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1075089004674	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
1075089004675	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1075089004676	Cysteine-rich domain; Region: CCG; pfam02754
1075089004677	Cysteine-rich domain; Region: CCG; pfam02754
1075089004678	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1075089004679	L-lactate permease; Region: Lactate_perm; cl00701
1075089004680	adenylosuccinate lyase; Provisional; Region: PRK09285
1075089004681	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
1075089004682	tetramer interface [polypeptide binding]; other site
1075089004683	active site
1075089004684	Uncharacterized protein involved in purine metabolism [General function prediction only]; Region: COG2915
1075089004685	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1075089004686	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1075089004687	putative substrate binding site [chemical binding]; other site
1075089004688	putative ATP binding site [chemical binding]; other site
1075089004689	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1075089004690	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1075089004691	substrate binding [chemical binding]; other site
1075089004692	active site
1075089004693	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1075089004694	D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417
1075089004695	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1075089004696	DNA binding site [nucleotide binding]
1075089004697	domain linker motif; other site
1075089004698	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
1075089004699	dimerization interface [polypeptide binding]; other site
1075089004700	ligand binding site [chemical binding]; other site
1075089004701	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1075089004702	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1075089004703	active site turn [active]
1075089004704	phosphorylation site [posttranslational modification]
1075089004705	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1075089004706	Copper(I)-binding protein [Inorganic ion transport and    metabolism]; Region: COG2847
1075089004707	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1075089004708	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1075089004709	putative active site [active]
1075089004710	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1075089004711	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1075089004712	putative active site [active]
1075089004713	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
1075089004714	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1075089004715	ATP binding site [chemical binding]; other site
1075089004716	Mg++ binding site [ion binding]; other site
1075089004717	motif III; other site
1075089004718	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1075089004719	nucleotide binding region [chemical binding]; other site
1075089004720	ATP-binding site [chemical binding]; other site
1075089004721	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1075089004722	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089004723	S-adenosylmethionine binding site [chemical binding]; other site
1075089004724	Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
1075089004725	ATP-dependent helicase HepA; Validated; Region: PRK04914
1075089004726	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1075089004727	ATP binding site [chemical binding]; other site
1075089004728	putative Mg++ binding site [ion binding]; other site
1075089004729	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1075089004730	nucleotide binding region [chemical binding]; other site
1075089004731	ATP-binding site [chemical binding]; other site
1075089004732	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1075089004733	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1075089004734	active site
1075089004735	Der GTPase activator (YihI); Region: YihI; pfam04220
1075089004736	Protein of unknown function (DUF2489); Region: DUF2489; pfam10675
1075089004737	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
1075089004738	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1075089004739	FeS/SAM binding site; other site
1075089004740	HemN C-terminal domain; Region: HemN_C; pfam06969
1075089004741	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1075089004742	dimer interface [polypeptide binding]; other site
1075089004743	FMN binding site [chemical binding]; other site
1075089004744	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1075089004745	non-specific DNA binding site [nucleotide binding]; other site
1075089004746	salt bridge; other site
1075089004747	sequence-specific DNA binding site [nucleotide binding]; other site
1075089004748	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1075089004749	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1075089004750	Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702
1075089004751	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1075089004752	MutS domain I; Region: MutS_I; pfam01624
1075089004753	MutS domain II; Region: MutS_II; pfam05188
1075089004754	MutS domain III; Region: MutS_III; pfam05192
1075089004755	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1075089004756	Walker A/P-loop; other site
1075089004757	ATP binding site [chemical binding]; other site
1075089004758	Q-loop/lid; other site
1075089004759	ABC transporter signature motif; other site
1075089004760	Walker B; other site
1075089004761	D-loop; other site
1075089004762	H-loop/switch region; other site
1075089004763	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1075089004764	metal ion-dependent adhesion site (MIDAS); other site
1075089004765	VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456
1075089004766	metal ion-dependent adhesion site (MIDAS); other site
1075089004767	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1075089004768	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1075089004769	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1075089004770	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1075089004771	FtsX-like permease family; Region: FtsX; pfam02687
1075089004772	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1075089004773	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1075089004774	Walker A/P-loop; other site
1075089004775	ATP binding site [chemical binding]; other site
1075089004776	Q-loop/lid; other site
1075089004777	ABC transporter signature motif; other site
1075089004778	Walker B; other site
1075089004779	D-loop; other site
1075089004780	H-loop/switch region; other site
1075089004781	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1075089004782	metal ion-dependent adhesion site (MIDAS); other site
1075089004783	Putative bacterial virulence factor; Region: Virul_Fac; pfam10139
1075089004784	Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457
1075089004785	recombinase A; Provisional; Region: recA; PRK09354
1075089004786	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1075089004787	hexamer interface [polypeptide binding]; other site
1075089004788	Walker A motif; other site
1075089004789	ATP binding site [chemical binding]; other site
1075089004790	Walker B motif; other site
1075089004791	recombination regulator RecX; Reviewed; Region: recX; PRK00117
1075089004792	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
1075089004793	HemY protein N-terminus; Region: HemY_N; pfam07219
1075089004794	HemX; Region: HemX; pfam04375
1075089004795	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
1075089004796	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1075089004797	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1075089004798	active site
1075089004799	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1075089004800	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1075089004801	domain interfaces; other site
1075089004802	active site
1075089004803	Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072
1075089004804	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
1075089004805	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
1075089004806	transcriptional regulator NarP; Provisional; Region: PRK10403
1075089004807	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1075089004808	active site
1075089004809	phosphorylation site [posttranslational modification]
1075089004810	intermolecular recognition site; other site
1075089004811	dimerization interface [polypeptide binding]; other site
1075089004812	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1075089004813	DNA binding residues [nucleotide binding]
1075089004814	dimerization interface [polypeptide binding]; other site
1075089004815	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
1075089004816	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1075089004817	Surface antigen; Region: Bac_surface_Ag; pfam01103
1075089004818	LysE type translocator; Region: LysE; cl00565
1075089004819	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
1075089004820	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1075089004821	Family of unknown function (DUF490); Region: DUF490; pfam04357
1075089004822	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
1075089004823	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1075089004824	Substrate binding site; other site
1075089004825	Mg++ binding site; other site
1075089004826	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1075089004827	active site
1075089004828	substrate binding site [chemical binding]; other site
1075089004829	CoA binding site [chemical binding]; other site
1075089004830	Putative SAM-dependent methyltransferase; Region: SAM_MT; pfam04445
1075089004831	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
1075089004832	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089004833	S-adenosylmethionine binding site [chemical binding]; other site
1075089004834	hypothetical protein; Provisional; Region: PRK11027
1075089004835	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
1075089004836	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1075089004837	catalytic residues [active]
1075089004838	hinge region; other site
1075089004839	alpha helical domain; other site
1075089004840	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3084
1075089004841	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1075089004842	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1075089004843	GTP binding site; other site
1075089004844	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
1075089004845	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1075089004846	active site
1075089004847	phosphorylation site [posttranslational modification]
1075089004848	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1075089004849	dimerization domain swap beta strand [polypeptide binding]; other site
1075089004850	regulatory protein interface [polypeptide binding]; other site
1075089004851	active site
1075089004852	regulatory phosphorylation site [posttranslational modification]; other site
1075089004853	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1075089004854	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1075089004855	putative substrate binding site [chemical binding]; other site
1075089004856	putative ATP binding site [chemical binding]; other site
1075089004857	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
1075089004858	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1075089004859	active site
1075089004860	P-loop; other site
1075089004861	phosphorylation site [posttranslational modification]
1075089004862	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1075089004863	active site
1075089004864	P-loop; other site
1075089004865	phosphorylation site [posttranslational modification]
1075089004866	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
1075089004867	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
1075089004868	Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318
1075089004869	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
1075089004870	molybdopterin cofactor binding site [chemical binding]; other site
1075089004871	substrate binding site [chemical binding]; other site
1075089004872	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
1075089004873	molybdopterin cofactor binding site; other site
1075089004874	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
1075089004875	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
1075089004876	Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848
1075089004877	Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292
1075089004878	Uncharacterized conserved protein [Function unknown]; Region: COG2938
1075089004879	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
1075089004880	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1075089004881	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1075089004882	DNA binding residues [nucleotide binding]
1075089004883	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073
1075089004884	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
1075089004885	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
1075089004886	anti-sigma E factor; Provisional; Region: rseB; PRK09455
1075089004887	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
1075089004888	Positive regulator of sigma E activity [Signal transduction mechanisms]; Region: RseC; COG3086
1075089004889	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
1075089004890	Walker A motif; other site
1075089004891	putative transporter; Provisional; Region: PRK10504
1075089004892	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1075089004893	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1075089004894	Uncharacterized conserved protein [Function unknown]; Region: COG4933
1075089004895	Abortive infection bacteriophage resistance protein [Defense mechanisms]; Region: AbiF; COG4823
1075089004896	Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519
1075089004897	Ash protein family; Region: Phage_ASH; pfam10554
1075089004898	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
1075089004899	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646
1075089004900	integrase; Provisional; Region: PRK09692
1075089004901	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1075089004902	active site
1075089004903	Int/Topo IB signature motif; other site
1075089004904	selenocysteine synthase; Provisional; Region: PRK04311
1075089004905	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
1075089004906	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
1075089004907	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1075089004908	catalytic residue [active]
1075089004909	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1075089004910	active site
1075089004911	tetramer interface [polypeptide binding]; other site
1075089004912	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
1075089004913	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
1075089004914	G1 box; other site
1075089004915	putative GEF interaction site [polypeptide binding]; other site
1075089004916	GTP/Mg2+ binding site [chemical binding]; other site
1075089004917	Switch I region; other site
1075089004918	G2 box; other site
1075089004919	G3 box; other site
1075089004920	Switch II region; other site
1075089004921	G4 box; other site
1075089004922	G5 box; other site
1075089004923	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
1075089004924	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
1075089004925	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
1075089004926	DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cl02442
1075089004927	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
1075089004928	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1075089004929	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1075089004930	twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621
1075089004931	DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976
1075089004932	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
1075089004933	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
1075089004934	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
1075089004935	putative [Fe4-S4] binding site [ion binding]; other site
1075089004936	putative molybdopterin cofactor binding site [chemical binding]; other site
1075089004937	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
1075089004938	putative molybdopterin cofactor binding site; other site
1075089004939	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1075089004940	MgtC family; Region: MgtC; pfam02308
1075089004941	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1075089004942	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1075089004943	Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264
1075089004944	active site turn [active]
1075089004945	phosphorylation site [posttranslational modification]
1075089004946	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
1075089004947	UbiA prenyltransferase family; Region: UbiA; pfam01040
1075089004948	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1075089004949	HslU subunit interaction site [polypeptide binding]; other site
1075089004950	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1075089004951	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1075089004952	Walker A motif; other site
1075089004953	ATP binding site [chemical binding]; other site
1075089004954	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1075089004955	Walker B motif; other site
1075089004956	arginine finger; other site
1075089004957	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1075089004958	pantothenate kinase; Provisional; Region: PRK05439
1075089004959	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1075089004960	ATP-binding site [chemical binding]; other site
1075089004961	CoA-binding site [chemical binding]; other site
1075089004962	Mg2+-binding site [ion binding]; other site
1075089004963	elongation factor Tu; Reviewed; Region: PRK00049
1075089004964	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1075089004965	G1 box; other site
1075089004966	GEF interaction site [polypeptide binding]; other site
1075089004967	GTP/Mg2+ binding site [chemical binding]; other site
1075089004968	Switch I region; other site
1075089004969	G2 box; other site
1075089004970	G3 box; other site
1075089004971	Switch II region; other site
1075089004972	G4 box; other site
1075089004973	G5 box; other site
1075089004974	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1075089004975	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1075089004976	Antibiotic Binding Site [chemical binding]; other site
1075089004977	Predicted peptidase [General function prediction only]; Region: COG4099
1075089004978	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1075089004979	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1075089004980	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
1075089004981	putative NAD(P) binding site [chemical binding]; other site
1075089004982	active site
1075089004983	putative substrate binding site [chemical binding]; other site
1075089004984	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1075089004985	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1075089004986	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1075089004987	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
1075089004988	putative aldolase; Validated; Region: PRK08130
1075089004989	intersubunit interface [polypeptide binding]; other site
1075089004990	active site
1075089004991	Zn2+ binding site [ion binding]; other site
1075089004992	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1075089004993	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1075089004994	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1075089004995	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1075089004996	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1075089004997	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1075089004998	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
1075089004999	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
1075089005000	metal binding site [ion binding]; metal-binding site
1075089005001	dimer interface [polypeptide binding]; other site
1075089005002	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1075089005003	active site
1075089005004	mannonate dehydratase; Provisional; Region: PRK03906
1075089005005	mannonate dehydratase; Region: uxuA; TIGR00695
1075089005006	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
1075089005007	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1075089005008	DNA-binding site [nucleotide binding]; DNA binding site
1075089005009	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1075089005010	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1075089005011	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1075089005012	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1075089005013	DctM-like transporters; Region: DctM; pfam06808
1075089005014	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1075089005015	DctM-like transporters; Region: DctM; pfam06808
1075089005016	D-mannonate oxidoreductase; Provisional; Region: PRK08277
1075089005017	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
1075089005018	putative NAD(P) binding site [chemical binding]; other site
1075089005019	active site
1075089005020	Glucuronate isomerase; Region: UxaC; pfam02614
1075089005021	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
1075089005022	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1075089005023	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1075089005024	substrate binding site [chemical binding]; other site
1075089005025	ATP binding site [chemical binding]; other site
1075089005026	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
1075089005027	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1075089005028	active site
1075089005029	intersubunit interface [polypeptide binding]; other site
1075089005030	catalytic residue [active]
1075089005031	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1075089005032	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1075089005033	dimer interface [polypeptide binding]; other site
1075089005034	motif 1; other site
1075089005035	active site
1075089005036	motif 2; other site
1075089005037	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1075089005038	putative deacylase active site [active]
1075089005039	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1075089005040	active site
1075089005041	motif 3; other site
1075089005042	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1075089005043	anticodon binding site; other site
1075089005044	D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809
1075089005045	N- and C-terminal domain interface [polypeptide binding]; other site
1075089005046	D-xylulose kinase; Region: XylB; TIGR01312
1075089005047	active site
1075089005048	MgATP binding site [chemical binding]; other site
1075089005049	catalytic site [active]
1075089005050	metal binding site [ion binding]; metal-binding site
1075089005051	xylulose binding site [chemical binding]; other site
1075089005052	putative homodimer interface [polypeptide binding]; other site
1075089005053	xylose isomerase; Provisional; Region: PRK05474
1075089005054	xylose isomerase; Region: xylose_isom_A; TIGR02630
1075089005055	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1075089005056	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1075089005057	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1075089005058	homodimer interface [polypeptide binding]; other site
1075089005059	catalytic residue [active]
1075089005060	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1075089005061	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
1075089005062	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
1075089005063	putative ligand binding site [chemical binding]; other site
1075089005064	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
1075089005065	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1075089005066	Walker A/P-loop; other site
1075089005067	ATP binding site [chemical binding]; other site
1075089005068	Q-loop/lid; other site
1075089005069	ABC transporter signature motif; other site
1075089005070	Walker B; other site
1075089005071	D-loop; other site
1075089005072	H-loop/switch region; other site
1075089005073	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1075089005074	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1075089005075	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1075089005076	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1075089005077	TM-ABC transporter signature motif; other site
1075089005078	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
1075089005079	putative dimerization interface [polypeptide binding]; other site
1075089005080	putative ligand binding site [chemical binding]; other site
1075089005081	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1075089005082	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1075089005083	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1075089005084	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
1075089005085	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1075089005086	substrate binding site [chemical binding]; other site
1075089005087	ATP binding site [chemical binding]; other site
1075089005088	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1075089005089	intersubunit interface [polypeptide binding]; other site
1075089005090	active site
1075089005091	zinc binding site [ion binding]; other site
1075089005092	Na+ binding site [ion binding]; other site
1075089005093	Protein of unknown function (DUF1498); Region: DUF1498; cl17840
1075089005094	fructokinase; Reviewed; Region: PRK09557
1075089005095	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1075089005096	nucleotide binding site [chemical binding]; other site
1075089005097	Acetokinase family; Region: Acetate_kinase; cl17229
1075089005098	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1075089005099	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1075089005100	active site
1075089005101	phosphorylation site [posttranslational modification]
1075089005102	intermolecular recognition site; other site
1075089005103	dimerization interface [polypeptide binding]; other site
1075089005104	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1075089005105	DNA binding site [nucleotide binding]
1075089005106	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1075089005107	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
1075089005108	putative ligand binding site [chemical binding]; other site
1075089005109	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1075089005110	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1075089005111	TM-ABC transporter signature motif; other site
1075089005112	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1075089005113	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1075089005114	Walker A/P-loop; other site
1075089005115	ATP binding site [chemical binding]; other site
1075089005116	Q-loop/lid; other site
1075089005117	ABC transporter signature motif; other site
1075089005118	Walker B; other site
1075089005119	D-loop; other site
1075089005120	H-loop/switch region; other site
1075089005121	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1075089005122	Pirin-related protein [General function prediction only]; Region: COG1741
1075089005123	Pirin; Region: Pirin; pfam02678
1075089005124	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1075089005125	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1075089005126	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1075089005127	heme-binding site [chemical binding]; other site
1075089005128	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1075089005129	FAD binding pocket [chemical binding]; other site
1075089005130	FAD binding motif [chemical binding]; other site
1075089005131	phosphate binding motif [ion binding]; other site
1075089005132	beta-alpha-beta structure motif; other site
1075089005133	NAD binding pocket [chemical binding]; other site
1075089005134	Heme binding  pocket [chemical binding]; other site
1075089005135	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1075089005136	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1075089005137	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1075089005138	dimer interface [polypeptide binding]; other site
1075089005139	phosphorylation site [posttranslational modification]
1075089005140	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1075089005141	ATP binding site [chemical binding]; other site
1075089005142	Mg2+ binding site [ion binding]; other site
1075089005143	G-X-G motif; other site
1075089005144	Response regulator receiver domain; Region: Response_reg; pfam00072
1075089005145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1075089005146	active site
1075089005147	phosphorylation site [posttranslational modification]
1075089005148	intermolecular recognition site; other site
1075089005149	dimerization interface [polypeptide binding]; other site
1075089005150	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
1075089005151	agmatinase; Region: agmatinase; TIGR01230
1075089005152	oligomer interface [polypeptide binding]; other site
1075089005153	putative active site [active]
1075089005154	Mn binding site [ion binding]; other site
1075089005155	Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166
1075089005156	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
1075089005157	dimer interface [polypeptide binding]; other site
1075089005158	active site
1075089005159	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1075089005160	catalytic residues [active]
1075089005161	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1075089005162	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1075089005163	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1075089005164	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
1075089005165	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
1075089005166	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK01792
1075089005167	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
1075089005168	Membrane fusogenic activity; Region: BMFP; cl01115
1075089005169	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1075089005170	non-specific DNA binding site [nucleotide binding]; other site
1075089005171	salt bridge; other site
1075089005172	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
1075089005173	sequence-specific DNA binding site [nucleotide binding]; other site
1075089005174	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
1075089005175	active site
1075089005176	(T/H)XGH motif; other site
1075089005177	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
1075089005178	Diadenosine tetraphosphatase and related serine/threonine protein phosphatases [Signal transduction mechanisms]; Region: ApaH; COG0639
1075089005179	Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203
1075089005180	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1075089005181	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1075089005182	alphaNTD homodimer interface [polypeptide binding]; other site
1075089005183	alphaNTD - beta interaction site [polypeptide binding]; other site
1075089005184	alphaNTD - beta' interaction site [polypeptide binding]; other site
1075089005185	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1075089005186	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1075089005187	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1075089005188	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1075089005189	RNA binding surface [nucleotide binding]; other site
1075089005190	30S ribosomal protein S11; Validated; Region: PRK05309
1075089005191	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1075089005192	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1075089005193	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
1075089005194	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1075089005195	SecY translocase; Region: SecY; pfam00344
1075089005196	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1075089005197	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1075089005198	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1075089005199	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1075089005200	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1075089005201	5S rRNA interface [nucleotide binding]; other site
1075089005202	L27 interface [polypeptide binding]; other site
1075089005203	23S rRNA interface [nucleotide binding]; other site
1075089005204	L5 interface [polypeptide binding]; other site
1075089005205	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1075089005206	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1075089005207	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1075089005208	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1075089005209	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1075089005210	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1075089005211	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1075089005212	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1075089005213	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1075089005214	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1075089005215	RNA binding site [nucleotide binding]; other site
1075089005216	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1075089005217	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1075089005218	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1075089005219	23S rRNA interface [nucleotide binding]; other site
1075089005220	putative translocon interaction site; other site
1075089005221	signal recognition particle (SRP54) interaction site; other site
1075089005222	L23 interface [polypeptide binding]; other site
1075089005223	trigger factor interaction site; other site
1075089005224	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1075089005225	23S rRNA interface [nucleotide binding]; other site
1075089005226	5S rRNA interface [nucleotide binding]; other site
1075089005227	putative antibiotic binding site [chemical binding]; other site
1075089005228	L25 interface [polypeptide binding]; other site
1075089005229	L27 interface [polypeptide binding]; other site
1075089005230	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1075089005231	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1075089005232	G-X-X-G motif; other site
1075089005233	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1075089005234	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1075089005235	protein-rRNA interface [nucleotide binding]; other site
1075089005236	putative translocon binding site; other site
1075089005237	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1075089005238	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1075089005239	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1075089005240	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1075089005241	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1075089005242	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1075089005243	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1075089005244	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1075089005245	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1075089005246	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
1075089005247	putative ion selectivity filter; other site
1075089005248	putative pore gating glutamate residue; other site
1075089005249	putative H+/Cl- coupling transport residue; other site
1075089005250	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
1075089005251	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1075089005252	FMN binding site [chemical binding]; other site
1075089005253	active site
1075089005254	catalytic residues [active]
1075089005255	substrate binding site [chemical binding]; other site
1075089005256	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222
1075089005257	aromatic amino acid transport protein; Region: araaP; TIGR00837
1075089005258	tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617
1075089005259	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1075089005260	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1075089005261	catalytic residue [active]
1075089005262	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919
1075089005263	oxaloacetate decarboxylase; Provisional; Region: PRK14040
1075089005264	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1075089005265	active site
1075089005266	catalytic residues [active]
1075089005267	metal binding site [ion binding]; metal-binding site
1075089005268	homodimer binding site [polypeptide binding]; other site
1075089005269	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1075089005270	carboxyltransferase (CT) interaction site; other site
1075089005271	biotinylation site [posttranslational modification]; other site
1075089005272	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
1075089005273	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1075089005274	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1075089005275	active site
1075089005276	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1075089005277	substrate binding site [chemical binding]; other site
1075089005278	catalytic residues [active]
1075089005279	dimer interface [polypeptide binding]; other site
1075089005280	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627
1075089005281	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
1075089005282	putative iron binding site [ion binding]; other site
1075089005283	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
1075089005284	substrate binding site [chemical binding]; other site
1075089005285	dimerization interface [polypeptide binding]; other site
1075089005286	active site
1075089005287	calcium binding site [ion binding]; other site
1075089005288	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
1075089005289	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1075089005290	ATP binding site [chemical binding]; other site
1075089005291	putative Mg++ binding site [ion binding]; other site
1075089005292	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1075089005293	nucleotide binding region [chemical binding]; other site
1075089005294	ATP-binding site [chemical binding]; other site
1075089005295	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1075089005296	HRDC domain; Region: HRDC; pfam00570
1075089005297	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1075089005298	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
1075089005299	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
1075089005300	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
1075089005301	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1075089005302	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1075089005303	shikimate binding site; other site
1075089005304	NAD(P) binding site [chemical binding]; other site
1075089005305	serine acetyltransferase; Provisional; Region: cysE; PRK11132
1075089005306	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
1075089005307	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1075089005308	trimer interface [polypeptide binding]; other site
1075089005309	active site
1075089005310	substrate binding site [chemical binding]; other site
1075089005311	CoA binding site [chemical binding]; other site
1075089005312	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1075089005313	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1075089005314	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1075089005315	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
1075089005316	SecA binding site; other site
1075089005317	Preprotein binding site; other site
1075089005318	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1075089005319	active site residue [active]
1075089005320	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
1075089005321	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
1075089005322	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
1075089005323	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1075089005324	Walker A motif; other site
1075089005325	ATP binding site [chemical binding]; other site
1075089005326	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
1075089005327	active site residue [active]
1075089005328	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
1075089005329	rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239
1075089005330	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1075089005331	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
1075089005332	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1075089005333	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1075089005334	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
1075089005335	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1075089005336	Cysteine-rich domain; Region: CCG; pfam02754
1075089005337	Cysteine-rich domain; Region: CCG; pfam02754
1075089005338	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075
1075089005339	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
1075089005340	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
1075089005341	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1075089005342	glycerol-3-phosphate transporter; Region: glpT; TIGR00712
1075089005343	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1075089005344	putative substrate translocation pore; other site
1075089005345	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1075089005346	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
1075089005347	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
1075089005348	active site
1075089005349	catalytic site [active]
1075089005350	metal binding site [ion binding]; metal-binding site
1075089005351	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1075089005352	amphipathic channel; other site
1075089005353	Asn-Pro-Ala signature motifs; other site
1075089005354	glycerol kinase; Provisional; Region: glpK; PRK00047
1075089005355	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1075089005356	N- and C-terminal domain interface [polypeptide binding]; other site
1075089005357	active site
1075089005358	MgATP binding site [chemical binding]; other site
1075089005359	catalytic site [active]
1075089005360	metal binding site [ion binding]; metal-binding site
1075089005361	glycerol binding site [chemical binding]; other site
1075089005362	homotetramer interface [polypeptide binding]; other site
1075089005363	homodimer interface [polypeptide binding]; other site
1075089005364	FBP binding site [chemical binding]; other site
1075089005365	protein IIAGlc interface [polypeptide binding]; other site
1075089005366	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
1075089005367	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1075089005368	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1075089005369	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1075089005370	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1075089005371	RNA binding site [nucleotide binding]; other site
1075089005372	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
1075089005373	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1075089005374	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1075089005375	Predicted membrane protein [Function unknown]; Region: COG1584
1075089005376	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1075089005377	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1075089005378	putative catalytic cysteine [active]
1075089005379	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1075089005380	putative active site [active]
1075089005381	metal binding site [ion binding]; metal-binding site
1075089005382	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1075089005383	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1075089005384	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1075089005385	Walker A/P-loop; other site
1075089005386	ATP binding site [chemical binding]; other site
1075089005387	Q-loop/lid; other site
1075089005388	ABC transporter signature motif; other site
1075089005389	Walker B; other site
1075089005390	D-loop; other site
1075089005391	H-loop/switch region; other site
1075089005392	TOBE domain; Region: TOBE_2; pfam08402
1075089005393	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1075089005394	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089005395	dimer interface [polypeptide binding]; other site
1075089005396	conserved gate region; other site
1075089005397	putative PBP binding loops; other site
1075089005398	ABC-ATPase subunit interface; other site
1075089005399	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089005400	dimer interface [polypeptide binding]; other site
1075089005401	conserved gate region; other site
1075089005402	putative PBP binding loops; other site
1075089005403	ABC-ATPase subunit interface; other site
1075089005404	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1075089005405	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1075089005406	Walker A/P-loop; other site
1075089005407	ATP binding site [chemical binding]; other site
1075089005408	Q-loop/lid; other site
1075089005409	ABC transporter signature motif; other site
1075089005410	Walker B; other site
1075089005411	D-loop; other site
1075089005412	H-loop/switch region; other site
1075089005413	TOBE domain; Region: TOBE_2; pfam08402
1075089005414	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
1075089005415	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1075089005416	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1075089005417	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1075089005418	Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192
1075089005419	HAMP domain; Region: HAMP; pfam00672
1075089005420	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1075089005421	dimer interface [polypeptide binding]; other site
1075089005422	phosphorylation site [posttranslational modification]
1075089005423	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1075089005424	ATP binding site [chemical binding]; other site
1075089005425	Mg2+ binding site [ion binding]; other site
1075089005426	G-X-G motif; other site
1075089005427	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1075089005428	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1075089005429	active site
1075089005430	phosphorylation site [posttranslational modification]
1075089005431	intermolecular recognition site; other site
1075089005432	dimerization interface [polypeptide binding]; other site
1075089005433	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1075089005434	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1075089005435	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
1075089005436	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1075089005437	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1075089005438	glutamine binding [chemical binding]; other site
1075089005439	catalytic triad [active]
1075089005440	para-aminobenzoate synthase component I; Validated; Region: PRK07093
1075089005441	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1075089005442	hypothetical protein; Provisional; Region: PRK07101
1075089005443	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1075089005444	substrate-cofactor binding pocket; other site
1075089005445	homodimer interface [polypeptide binding]; other site
1075089005446	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1075089005447	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1075089005448	homotrimer interaction site [polypeptide binding]; other site
1075089005449	putative active site [active]
1075089005450	NIPSNAP; Region: NIPSNAP; pfam07978
1075089005451	Site-specific recombinase [DNA replication, recombination, and repair]; Region: COG4389
1075089005452	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
1075089005453	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1075089005454	substrate binding site [chemical binding]; other site
1075089005455	Predicted transcriptional regulators [Transcription]; Region: COG1733
1075089005456	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1075089005457	Predicted flavoprotein [General function prediction only]; Region: COG0431
1075089005458	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1075089005459	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1075089005460	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1075089005461	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1075089005462	Walker A/P-loop; other site
1075089005463	ATP binding site [chemical binding]; other site
1075089005464	Q-loop/lid; other site
1075089005465	ABC transporter signature motif; other site
1075089005466	Walker B; other site
1075089005467	D-loop; other site
1075089005468	H-loop/switch region; other site
1075089005469	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
1075089005470	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1075089005471	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1075089005472	Walker A/P-loop; other site
1075089005473	ATP binding site [chemical binding]; other site
1075089005474	Q-loop/lid; other site
1075089005475	ABC transporter signature motif; other site
1075089005476	Walker B; other site
1075089005477	D-loop; other site
1075089005478	H-loop/switch region; other site
1075089005479	EamA-like transporter family; Region: EamA; pfam00892
1075089005480	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1075089005481	EamA-like transporter family; Region: EamA; pfam00892
1075089005482	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
1075089005483	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1075089005484	ATP binding site [chemical binding]; other site
1075089005485	Mg2+ binding site [ion binding]; other site
1075089005486	G-X-G motif; other site
1075089005487	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1075089005488	anchoring element; other site
1075089005489	dimer interface [polypeptide binding]; other site
1075089005490	ATP binding site [chemical binding]; other site
1075089005491	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1075089005492	active site
1075089005493	putative metal-binding site [ion binding]; other site
1075089005494	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1075089005495	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1075089005496	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1075089005497	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527
1075089005498	active site residue [active]
1075089005499	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1075089005500	dimerization interface [polypeptide binding]; other site
1075089005501	putative DNA binding site [nucleotide binding]; other site
1075089005502	putative Zn2+ binding site [ion binding]; other site
1075089005503	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1075089005504	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1075089005505	putative active site [active]
1075089005506	Protein of unknown function (DUF904); Region: DUF904; pfam06005
1075089005507	FMN-binding protein MioC; Provisional; Region: PRK09004
1075089005508	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1075089005509	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
1075089005510	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
1075089005511	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1075089005512	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1075089005513	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1075089005514	F0F1 ATP synthase subunit I; Validated; Region: PRK06099
1075089005515	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1075089005516	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1075089005517	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1075089005518	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1075089005519	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1075089005520	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1075089005521	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1075089005522	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1075089005523	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1075089005524	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1075089005525	beta subunit interaction interface [polypeptide binding]; other site
1075089005526	Walker A motif; other site
1075089005527	ATP binding site [chemical binding]; other site
1075089005528	Walker B motif; other site
1075089005529	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1075089005530	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1075089005531	core domain interface [polypeptide binding]; other site
1075089005532	delta subunit interface [polypeptide binding]; other site
1075089005533	epsilon subunit interface [polypeptide binding]; other site
1075089005534	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1075089005535	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1075089005536	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1075089005537	alpha subunit interaction interface [polypeptide binding]; other site
1075089005538	Walker A motif; other site
1075089005539	ATP binding site [chemical binding]; other site
1075089005540	Walker B motif; other site
1075089005541	inhibitor binding site; inhibition site
1075089005542	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1075089005543	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1075089005544	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1075089005545	gamma subunit interface [polypeptide binding]; other site
1075089005546	epsilon subunit interface [polypeptide binding]; other site
1075089005547	LBP interface [polypeptide binding]; other site
1075089005548	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
1075089005549	CPxP  motif; other site
1075089005550	hypothetical protein; Provisional; Region: PRK11568
1075089005551	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1075089005552	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1075089005553	Cation transport protein; Region: TrkH; cl17365
1075089005554	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1075089005555	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
1075089005556	hypothetical protein; Validated; Region: PRK05445
1075089005557	Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853
1075089005558	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1075089005559	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1075089005560	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1075089005561	catalytic site [active]
1075089005562	subunit interface [polypeptide binding]; other site
1075089005563	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1075089005564	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1075089005565	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
1075089005566	conserved cys residue [active]
1075089005567	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1075089005568	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1075089005569	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1075089005570	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1075089005571	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1075089005572	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1075089005573	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1075089005574	IMP binding site; other site
1075089005575	dimer interface [polypeptide binding]; other site
1075089005576	interdomain contacts; other site
1075089005577	partial ornithine binding site; other site
1075089005578	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1075089005579	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1075089005580	catalytic core [active]
1075089005581	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1075089005582	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
1075089005583	Peptidase family M23; Region: Peptidase_M23; pfam01551
1075089005584	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
1075089005585	NodB motif; other site
1075089005586	putative active site [active]
1075089005587	putative catalytic site [active]
1075089005588	Zn binding site [ion binding]; other site
1075089005589	Mg chelatase-related protein; Region: TIGR00368
1075089005590	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1075089005591	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1075089005592	Walker A motif; other site
1075089005593	ATP binding site [chemical binding]; other site
1075089005594	Walker B motif; other site
1075089005595	arginine finger; other site
1075089005596	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1075089005597	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1075089005598	G1 box; other site
1075089005599	GTP/Mg2+ binding site [chemical binding]; other site
1075089005600	Switch I region; other site
1075089005601	G2 box; other site
1075089005602	G3 box; other site
1075089005603	Switch II region; other site
1075089005604	G4 box; other site
1075089005605	G5 box; other site
1075089005606	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990
1075089005607	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1075089005608	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1075089005609	TPR motif; other site
1075089005610	binding surface
1075089005611	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1075089005612	Protein of unknown function (DUF560); Region: DUF560; pfam04575
1075089005613	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
1075089005614	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089005615	S-adenosylmethionine binding site [chemical binding]; other site
1075089005616	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1075089005617	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1075089005618	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1075089005619	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1075089005620	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1075089005621	P loop; other site
1075089005622	GTP binding site [chemical binding]; other site
1075089005623	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1075089005624	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1075089005625	Walker A/P-loop; other site
1075089005626	ATP binding site [chemical binding]; other site
1075089005627	Q-loop/lid; other site
1075089005628	ABC transporter signature motif; other site
1075089005629	Walker B; other site
1075089005630	D-loop; other site
1075089005631	H-loop/switch region; other site
1075089005632	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1075089005633	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
1075089005634	4-hydroxyphenylacetate 3-monooxygenase, reductase component; Region: HpaC; TIGR02296
1075089005635	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
1075089005636	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
1075089005637	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
1075089005638	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1075089005639	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1075089005640	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1075089005641	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1075089005642	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
1075089005643	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1075089005644	DctM-like transporters; Region: DctM; pfam06808
1075089005645	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1075089005646	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit; Region: HpaG-N-term; TIGR02305
1075089005647	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
1075089005648	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1075089005649	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
1075089005650	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
1075089005651	NAD binding site [chemical binding]; other site
1075089005652	catalytic residues [active]
1075089005653	The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370
1075089005654	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1075089005655	putative active site [active]
1075089005656	putative metal binding site [ion binding]; other site
1075089005657	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
1075089005658	putative substrate binding pocket [chemical binding]; other site
1075089005659	trimer interface [polypeptide binding]; other site
1075089005660	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1075089005661	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1075089005662	putative substrate translocation pore; other site
1075089005663	2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312
1075089005664	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311
1075089005665	succinic semialdehyde dehydrogenase; Region: PLN02278
1075089005666	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1075089005667	tetramerization interface [polypeptide binding]; other site
1075089005668	NAD(P) binding site [chemical binding]; other site
1075089005669	catalytic residues [active]
1075089005670	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1075089005671	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1075089005672	active site
1075089005673	substrate-binding site [chemical binding]; other site
1075089005674	metal-binding site [ion binding]
1075089005675	ATP binding site [chemical binding]; other site
1075089005676	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
1075089005677	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1075089005678	ADP-ribose binding site [chemical binding]; other site
1075089005679	dimer interface [polypeptide binding]; other site
1075089005680	active site
1075089005681	nudix motif; other site
1075089005682	metal binding site [ion binding]; metal-binding site
1075089005683	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1075089005684	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
1075089005685	motif II; other site
1075089005686	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1075089005687	RNA binding surface [nucleotide binding]; other site
1075089005688	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1075089005689	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1075089005690	dimerization interface [polypeptide binding]; other site
1075089005691	domain crossover interface; other site
1075089005692	redox-dependent activation switch; other site
1075089005693	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1075089005694	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1075089005695	active site
1075089005696	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1075089005697	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1075089005698	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1075089005699	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1075089005700	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1075089005701	putative active site [active]
1075089005702	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1075089005703	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
1075089005704	putative C-terminal domain interface [polypeptide binding]; other site
1075089005705	putative GSH binding site (G-site) [chemical binding]; other site
1075089005706	putative dimer interface [polypeptide binding]; other site
1075089005707	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
1075089005708	putative N-terminal domain interface [polypeptide binding]; other site
1075089005709	putative dimer interface [polypeptide binding]; other site
1075089005710	putative substrate binding pocket (H-site) [chemical binding]; other site
1075089005711	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1075089005712	Coenzyme A binding pocket [chemical binding]; other site
1075089005713	6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362
1075089005714	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1075089005715	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1075089005716	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1075089005717	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1075089005718	active site
1075089005719	motif I; other site
1075089005720	motif II; other site
1075089005721	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1075089005722	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1075089005723	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1075089005724	active site
1075089005725	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1075089005726	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
1075089005727	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
1075089005728	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
1075089005729	TfoX C-terminal domain; Region: TfoX_C; pfam04994
1075089005730	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1075089005731	active site
1075089005732	catalytic residues [active]
1075089005733	metal binding site [ion binding]; metal-binding site
1075089005734	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1075089005735	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1075089005736	putative active site [active]
1075089005737	substrate binding site [chemical binding]; other site
1075089005738	putative cosubstrate binding site; other site
1075089005739	catalytic site [active]
1075089005740	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1075089005741	substrate binding site [chemical binding]; other site
1075089005742	16S rRNA methyltransferase B; Provisional; Region: PRK10901
1075089005743	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
1075089005744	putative RNA binding site [nucleotide binding]; other site
1075089005745	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089005746	S-adenosylmethionine binding site [chemical binding]; other site
1075089005747	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1075089005748	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1075089005749	active site
1075089005750	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
1075089005751	TrkA-N domain; Region: TrkA_N; pfam02254
1075089005752	TrkA-C domain; Region: TrkA_C; pfam02080
1075089005753	TrkA-N domain; Region: TrkA_N; pfam02254
1075089005754	TrkA-C domain; Region: TrkA_C; pfam02080
1075089005755	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
1075089005756	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1075089005757	RNase E inhibitor protein; Provisional; Region: PRK11191
1075089005758	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
1075089005759	Predicted periplasmic/secreted protein [Function unknown]; Region: COG3471
1075089005760	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737
1075089005761	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1075089005762	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1075089005763	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841
1075089005764	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1075089005765	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1075089005766	active site
1075089005767	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
1075089005768	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
1075089005769	trimer interface [polypeptide binding]; other site
1075089005770	YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820
1075089005771	trimer interface [polypeptide binding]; other site
1075089005772	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
1075089005773	trimer interface [polypeptide binding]; other site
1075089005774	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
1075089005775	trimer interface [polypeptide binding]; other site
1075089005776	Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295
1075089005777	YadA-like C-terminal region; Region: YadA; pfam03895
1075089005778	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
1075089005779	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1075089005780	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1075089005781	FeS/SAM binding site; other site
1075089005782	TRAM domain; Region: TRAM; cl01282
1075089005783	uridine phosphorylase; Provisional; Region: PRK11178
1075089005784	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1075089005785	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
1075089005786	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1075089005787	putative DNA binding site [nucleotide binding]; other site
1075089005788	putative Zn2+ binding site [ion binding]; other site
1075089005789	AsnC family; Region: AsnC_trans_reg; pfam01037
1075089005790	Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502
1075089005791	motif 1; other site
1075089005792	dimer interface [polypeptide binding]; other site
1075089005793	active site
1075089005794	motif 2; other site
1075089005795	motif 3; other site
1075089005796	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
1075089005797	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1075089005798	active site turn [active]
1075089005799	phosphorylation site [posttranslational modification]
1075089005800	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1075089005801	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
1075089005802	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1075089005803	putative active site [active]
1075089005804	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1075089005805	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
1075089005806	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1075089005807	putative active site [active]
1075089005808	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
1075089005809	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1075089005810	substrate binding pocket [chemical binding]; other site
1075089005811	membrane-bound complex binding site; other site
1075089005812	Uncharacterized conserved protein [Function unknown]; Region: COG4729
1075089005813	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
1075089005814	DctM-like transporters; Region: DctM; pfam06808
1075089005815	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
1075089005816	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
1075089005817	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1075089005818	Walker A/P-loop; other site
1075089005819	ATP binding site [chemical binding]; other site
1075089005820	Q-loop/lid; other site
1075089005821	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1075089005822	ABC transporter; Region: ABC_tran_2; pfam12848
1075089005823	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1075089005824	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
1075089005825	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1075089005826	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1075089005827	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1075089005828	DNA binding residues [nucleotide binding]
1075089005829	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1075089005830	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1075089005831	transmembrane helices; other site
1075089005832	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
1075089005833	PLD-like domain; Region: PLDc_2; pfam13091
1075089005834	putative active site [active]
1075089005835	catalytic site [active]
1075089005836	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
1075089005837	PLD-like domain; Region: PLDc_2; pfam13091
1075089005838	putative active site [active]
1075089005839	catalytic site [active]
1075089005840	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
1075089005841	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
1075089005842	gating phenylalanine in ion channel; other site
1075089005843	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4390
1075089005844	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
1075089005845	FAD binding domain; Region: FAD_binding_4; pfam01565
1075089005846	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1075089005847	Peptidase E [Amino acid transport and metabolism]; Region: PepE; COG3340
1075089005848	conserved cys residue [active]
1075089005849	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
1075089005850	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
1075089005851	HAMP domain; Region: HAMP; pfam00672
1075089005852	Histidine kinase; Region: HisKA_3; pfam07730
1075089005853	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1075089005854	ATP binding site [chemical binding]; other site
1075089005855	Mg2+ binding site [ion binding]; other site
1075089005856	G-X-G motif; other site
1075089005857	ferredoxin-type protein NapF; Region: napF; TIGR00402
1075089005858	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1075089005859	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1075089005860	Uncharacterized protein involved in formation of periplasmic nitrate reductase [Inorganic ion transport and metabolism]; Region: NapD; COG3062
1075089005861	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
1075089005862	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1075089005863	[4Fe-4S] binding site [ion binding]; other site
1075089005864	molybdopterin cofactor binding site; other site
1075089005865	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1075089005866	molybdopterin cofactor binding site; other site
1075089005867	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
1075089005868	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
1075089005869	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1075089005870	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1075089005871	Nitrate reductase cytochrome c-type subunit [Energy production and conversion]; Region: NapB; COG3043
1075089005872	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
1075089005873	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
1075089005874	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
1075089005875	DNA protecting protein DprA; Region: dprA; TIGR00732
1075089005876	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
1075089005877	OstA-like protein; Region: OstA; pfam03968
1075089005878	Organic solvent tolerance protein; Region: OstA_C; pfam04453
1075089005879	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1075089005880	transaldolase-like protein; Provisional; Region: PTZ00411
1075089005881	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
1075089005882	active site
1075089005883	dimer interface [polypeptide binding]; other site
1075089005884	catalytic residue [active]
1075089005885	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
1075089005886	nudix motif; other site
1075089005887	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
1075089005888	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
1075089005889	probable active site [active]
1075089005890	isocitrate dehydrogenase; Validated; Region: PRK07362
1075089005891	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1075089005892	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
1075089005893	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1075089005894	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1075089005895	substrate binding site; other site
1075089005896	dimer interface; other site
1075089005897	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1075089005898	homotrimer interaction site [polypeptide binding]; other site
1075089005899	zinc binding site [ion binding]; other site
1075089005900	CDP-binding sites; other site
1075089005901	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
1075089005902	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
1075089005903	Permutation of conserved domain; other site
1075089005904	active site
1075089005905	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1075089005906	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1075089005907	Sel1-like repeats; Region: SEL1; smart00671
1075089005908	Sel1-like repeats; Region: SEL1; smart00671
1075089005909	Sel1-like repeats; Region: SEL1; smart00671
1075089005910	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
1075089005911	Predicted membrane protein [Function unknown]; Region: COG1238
1075089005912	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1075089005913	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1075089005914	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1075089005915	Peptidase family M23; Region: Peptidase_M23; pfam01551
1075089005916	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1075089005917	putative active site [active]
1075089005918	dimerization interface [polypeptide binding]; other site
1075089005919	putative tRNAtyr binding site [nucleotide binding]; other site
1075089005920	hypothetical protein; Reviewed; Region: PRK01637
1075089005921	hypothetical protein; Provisional; Region: PRK01752
1075089005922	SEC-C motif; Region: SEC-C; pfam02810
1075089005923	Lysine efflux permease [General function prediction only]; Region: COG1279
1075089005924	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1075089005925	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
1075089005926	substrate binding site [chemical binding]; other site
1075089005927	hexamer interface [polypeptide binding]; other site
1075089005928	metal binding site [ion binding]; metal-binding site
1075089005929	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1075089005930	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1075089005931	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1075089005932	motif II; other site
1075089005933	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1075089005934	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1075089005935	active site
1075089005936	HIGH motif; other site
1075089005937	dimer interface [polypeptide binding]; other site
1075089005938	KMSKS motif; other site
1075089005939	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
1075089005940	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
1075089005941	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1075089005942	threonine dehydratase; Reviewed; Region: PRK09224
1075089005943	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1075089005944	tetramer interface [polypeptide binding]; other site
1075089005945	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1075089005946	catalytic residue [active]
1075089005947	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
1075089005948	putative Ile/Val binding site [chemical binding]; other site
1075089005949	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1075089005950	putative Ile/Val binding site [chemical binding]; other site
1075089005951	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
1075089005952	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
1075089005953	aspartate racemase; Region: asp_race; TIGR00035
1075089005954	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
1075089005955	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
1075089005956	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1075089005957	PYR/PP interface [polypeptide binding]; other site
1075089005958	dimer interface [polypeptide binding]; other site
1075089005959	TPP binding site [chemical binding]; other site
1075089005960	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1075089005961	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1075089005962	TPP-binding site [chemical binding]; other site
1075089005963	dimer interface [polypeptide binding]; other site
1075089005964	putative hydrolase; Provisional; Region: PRK10976
1075089005965	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1075089005966	active site
1075089005967	motif I; other site
1075089005968	motif II; other site
1075089005969	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1075089005970	chromosome condensation membrane protein; Provisional; Region: PRK14196
1075089005971	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1075089005972	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1075089005973	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
1075089005974	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1075089005975	transketolase; Reviewed; Region: PRK12753
1075089005976	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1075089005977	TPP-binding site [chemical binding]; other site
1075089005978	dimer interface [polypeptide binding]; other site
1075089005979	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1075089005980	PYR/PP interface [polypeptide binding]; other site
1075089005981	dimer interface [polypeptide binding]; other site
1075089005982	TPP binding site [chemical binding]; other site
1075089005983	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1075089005984	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
1075089005985	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1075089005986	active site
1075089005987	motif I; other site
1075089005988	motif II; other site
1075089005989	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1075089005990	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
1075089005991	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
1075089005992	intersubunit interface [polypeptide binding]; other site
1075089005993	active site
1075089005994	Zn2+ binding site [ion binding]; other site
1075089005995	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
1075089005996	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1075089005997	AP (apurinic/apyrimidinic) site pocket; other site
1075089005998	DNA interaction; other site
1075089005999	Metal-binding active site; metal-binding site
1075089006000	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1075089006001	active site
1075089006002	dimer interface [polypeptide binding]; other site
1075089006003	magnesium binding site [ion binding]; other site
1075089006004	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1075089006005	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
1075089006006	putative N- and C-terminal domain interface [polypeptide binding]; other site
1075089006007	putative active site [active]
1075089006008	MgATP binding site [chemical binding]; other site
1075089006009	catalytic site [active]
1075089006010	metal binding site [ion binding]; metal-binding site
1075089006011	putative xylulose binding site [chemical binding]; other site
1075089006012	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1075089006013	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315
1075089006014	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1075089006015	putative ligand binding site [chemical binding]; other site
1075089006016	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1075089006017	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1075089006018	TM-ABC transporter signature motif; other site
1075089006019	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1075089006020	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1075089006021	Walker A/P-loop; other site
1075089006022	ATP binding site [chemical binding]; other site
1075089006023	Q-loop/lid; other site
1075089006024	ABC transporter signature motif; other site
1075089006025	Walker B; other site
1075089006026	D-loop; other site
1075089006027	H-loop/switch region; other site
1075089006028	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1075089006029	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1075089006030	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1075089006031	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1075089006032	DctM-like transporters; Region: DctM; pfam06808
1075089006033	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1075089006034	Domain of unknown function (DUF386); Region: DUF386; pfam04074
1075089006035	2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260
1075089006036	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1075089006037	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1075089006038	Bacterial transcriptional regulator; Region: IclR; pfam01614
1075089006039	hypothetical protein; Provisional; Region: PRK05208
1075089006040	metabolite-proton symporter; Region: 2A0106; TIGR00883
1075089006041	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1075089006042	putative substrate translocation pore; other site
1075089006043	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1075089006044	active site
1075089006045	thiamine phosphate binding site [chemical binding]; other site
1075089006046	pyrophosphate binding site [ion binding]; other site
1075089006047	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1075089006048	dimer interface [polypeptide binding]; other site
1075089006049	substrate binding site [chemical binding]; other site
1075089006050	ATP binding site [chemical binding]; other site
1075089006051	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1075089006052	multimerization interface [polypeptide binding]; other site
1075089006053	substrate binding site [chemical binding]; other site
1075089006054	ATP binding site [chemical binding]; other site
1075089006055	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1075089006056	NMT1/THI5 like; Region: NMT1; pfam09084
1075089006057	Putative transcription activator [Transcription]; Region: TenA; COG0819
1075089006058	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1075089006059	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089006060	dimer interface [polypeptide binding]; other site
1075089006061	conserved gate region; other site
1075089006062	putative PBP binding loops; other site
1075089006063	ABC-ATPase subunit interface; other site
1075089006064	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1075089006065	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1075089006066	Walker A/P-loop; other site
1075089006067	ATP binding site [chemical binding]; other site
1075089006068	Q-loop/lid; other site
1075089006069	ABC transporter signature motif; other site
1075089006070	Walker B; other site
1075089006071	D-loop; other site
1075089006072	H-loop/switch region; other site
1075089006073	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
1075089006074	RmuC family; Region: RmuC; pfam02646
1075089006075	Maf-like protein; Region: Maf; pfam02545
1075089006076	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1075089006077	active site
1075089006078	dimer interface [polypeptide binding]; other site
1075089006079	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
1075089006080	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1075089006081	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1075089006082	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1075089006083	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1075089006084	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1075089006085	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1075089006086	shikimate binding site; other site
1075089006087	NAD(P) binding site [chemical binding]; other site
1075089006088	autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939
1075089006089	Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775
1075089006090	putative N- and C-terminal domain interface [polypeptide binding]; other site
1075089006091	putative active site [active]
1075089006092	putative MgATP binding site [chemical binding]; other site
1075089006093	catalytic site [active]
1075089006094	metal binding site [ion binding]; metal-binding site
1075089006095	putative carbohydrate binding site [chemical binding]; other site
1075089006096	transcriptional regulator LsrR; Provisional; Region: PRK15418
1075089006097	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1075089006098	non-specific DNA interactions [nucleotide binding]; other site
1075089006099	DNA binding site [nucleotide binding]
1075089006100	sequence specific DNA binding site [nucleotide binding]; other site
1075089006101	putative cAMP binding site [chemical binding]; other site
1075089006102	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1075089006103	autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439
1075089006104	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1075089006105	Walker A/P-loop; other site
1075089006106	ATP binding site [chemical binding]; other site
1075089006107	Q-loop/lid; other site
1075089006108	ABC transporter signature motif; other site
1075089006109	Walker B; other site
1075089006110	D-loop; other site
1075089006111	H-loop/switch region; other site
1075089006112	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1075089006113	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1075089006114	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1075089006115	TM-ABC transporter signature motif; other site
1075089006116	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1075089006117	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1075089006118	TM-ABC transporter signature motif; other site
1075089006119	autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408
1075089006120	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
1075089006121	ligand binding site [chemical binding]; other site
1075089006122	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
1075089006123	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
1075089006124	putative active site; other site
1075089006125	catalytic residue [active]
1075089006126	autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486
1075089006127	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1075089006128	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1075089006129	substrate binding site [chemical binding]; other site
1075089006130	hexamer interface [polypeptide binding]; other site
1075089006131	metal binding site [ion binding]; metal-binding site
1075089006132	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1075089006133	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1075089006134	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1075089006135	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1075089006136	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
1075089006137	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
1075089006138	putative dimerization interface [polypeptide binding]; other site
1075089006139	ketol-acid reductoisomerase; Validated; Region: PRK05225
1075089006140	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1075089006141	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1075089006142	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1075089006143	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
1075089006144	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1075089006145	homodimer interface [polypeptide binding]; other site
1075089006146	metal binding site [ion binding]; metal-binding site
1075089006147	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1075089006148	homodimer interface [polypeptide binding]; other site
1075089006149	active site
1075089006150	putative chemical substrate binding site [chemical binding]; other site
1075089006151	metal binding site [ion binding]; metal-binding site
1075089006152	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1075089006153	Ligand Binding Site [chemical binding]; other site
1075089006154	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1075089006155	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1075089006156	motif 1; other site
1075089006157	active site
1075089006158	motif 2; other site
1075089006159	motif 3; other site
1075089006160	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1075089006161	DHHA1 domain; Region: DHHA1; pfam02272
1075089006162	carbon storage regulator; Provisional; Region: PRK01712
1075089006163	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1075089006164	active site
1075089006165	tetramer interface; other site
1075089006166	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
1075089006167	dimerization interface [polypeptide binding]; other site
1075089006168	DNA binding site [nucleotide binding]
1075089006169	corepressor binding sites; other site
1075089006170	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1075089006171	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1075089006172	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1075089006173	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1075089006174	Nucleoside recognition; Region: Gate; pfam07670
1075089006175	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1075089006176	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1075089006177	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1075089006178	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1075089006179	putative active site [active]
1075089006180	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1075089006181	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1075089006182	RimM N-terminal domain; Region: RimM; pfam01782
1075089006183	PRC-barrel domain; Region: PRC; pfam05239
1075089006184	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1075089006185	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1075089006186	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069
1075089006187	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1075089006188	M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665
1075089006189	putative metal binding site [ion binding]; other site
1075089006190	dimer interface [polypeptide binding]; other site
1075089006191	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
1075089006192	Autotransporter beta-domain; Region: Autotransporter; smart00869
1075089006193	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
1075089006194	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1075089006195	N-terminal plug; other site
1075089006196	ligand-binding site [chemical binding]; other site
1075089006197	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1075089006198	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1075089006199	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1075089006200	Walker A/P-loop; other site
1075089006201	ATP binding site [chemical binding]; other site
1075089006202	Q-loop/lid; other site
1075089006203	ABC transporter signature motif; other site
1075089006204	Walker B; other site
1075089006205	D-loop; other site
1075089006206	H-loop/switch region; other site
1075089006207	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1075089006208	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1075089006209	putative active site [active]
1075089006210	3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723
1075089006211	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1075089006212	active site
1075089006213	ATP binding site [chemical binding]; other site
1075089006214	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1075089006215	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1075089006216	active site
1075089006217	(T/H)XGH motif; other site
1075089006218	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
1075089006219	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
1075089006220	Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534
1075089006221	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1075089006222	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1075089006223	putative metal binding site; other site
1075089006224	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1075089006225	Metal binding protein HemV-2.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
1075089006226	putative metal binding site [ion binding]; other site
1075089006227	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1075089006228	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1075089006229	ABC-ATPase subunit  interface; other site
1075089006230	dimer interface [polypeptide binding]; other site
1075089006231	putative PBP binding regions; other site
1075089006232	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1075089006233	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1075089006234	Walker A/P-loop; other site
1075089006235	ATP binding site [chemical binding]; other site
1075089006236	Q-loop/lid; other site
1075089006237	ABC transporter signature motif; other site
1075089006238	Walker B; other site
1075089006239	D-loop; other site
1075089006240	H-loop/switch region; other site
1075089006241	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1075089006242	Methyltransferase domain; Region: Methyltransf_18; pfam12847
1075089006243	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1075089006244	triosephosphate isomerase; Provisional; Region: PRK14567
1075089006245	substrate binding site [chemical binding]; other site
1075089006246	dimer interface [polypeptide binding]; other site
1075089006247	catalytic triad [active]
1075089006248	hypothetical protein; Validated; Region: PRK05090
1075089006249	YGGT family; Region: YGGT; pfam02325
1075089006250	YGGT family; Region: YGGT; pfam02325
1075089006251	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1075089006252	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
1075089006253	Cl binding site [ion binding]; other site
1075089006254	oligomer interface [polypeptide binding]; other site
1075089006255	hypothetical protein; Provisional; Region: PRK11702
1075089006256	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
1075089006257	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1075089006258	adenine DNA glycosylase; Provisional; Region: PRK10880
1075089006259	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1075089006260	minor groove reading motif; other site
1075089006261	helix-hairpin-helix signature motif; other site
1075089006262	substrate binding pocket [chemical binding]; other site
1075089006263	active site
1075089006264	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1075089006265	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1075089006266	DNA binding and oxoG recognition site [nucleotide binding]
1075089006267	oxidative damage protection protein; Provisional; Region: PRK05408
1075089006268	murein transglycosylase C; Provisional; Region: mltC; PRK11671
1075089006269	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
1075089006270	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1075089006271	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1075089006272	catalytic residue [active]
1075089006273	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1075089006274	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1075089006275	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG3056
1075089006276	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
1075089006277	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
1075089006278	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1075089006279	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1075089006280	ligand binding site [chemical binding]; other site
1075089006281	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1075089006282	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1075089006283	Walker A/P-loop; other site
1075089006284	ATP binding site [chemical binding]; other site
1075089006285	Q-loop/lid; other site
1075089006286	ABC transporter signature motif; other site
1075089006287	Walker B; other site
1075089006288	D-loop; other site
1075089006289	H-loop/switch region; other site
1075089006290	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1075089006291	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1075089006292	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1075089006293	TM-ABC transporter signature motif; other site
1075089006294	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
1075089006295	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1075089006296	E3 interaction surface; other site
1075089006297	lipoyl attachment site [posttranslational modification]; other site
1075089006298	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
1075089006299	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
1075089006300	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869
1075089006301	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
1075089006302	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
1075089006303	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
1075089006304	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
1075089006305	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1075089006306	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
1075089006307	FAD binding pocket [chemical binding]; other site
1075089006308	FAD binding motif [chemical binding]; other site
1075089006309	phosphate binding motif [ion binding]; other site
1075089006310	beta-alpha-beta structure motif; other site
1075089006311	NAD binding pocket [chemical binding]; other site
1075089006312	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1075089006313	ApbE family; Region: ApbE; pfam02424
1075089006314	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991
1075089006315	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1075089006316	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1075089006317	Ligand Binding Site [chemical binding]; other site
1075089006318	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1075089006319	regulatory protein UhpC; Provisional; Region: PRK11663
1075089006320	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1075089006321	putative substrate translocation pore; other site
1075089006322	Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851
1075089006323	MASE1; Region: MASE1; pfam05231
1075089006324	Histidine kinase; Region: HisKA_3; pfam07730
1075089006325	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1075089006326	ATP binding site [chemical binding]; other site
1075089006327	G-X-G motif; other site
1075089006328	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
1075089006329	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1075089006330	active site
1075089006331	phosphorylation site [posttranslational modification]
1075089006332	intermolecular recognition site; other site
1075089006333	dimerization interface [polypeptide binding]; other site
1075089006334	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1075089006335	DNA binding residues [nucleotide binding]
1075089006336	dimerization interface [polypeptide binding]; other site
1075089006337	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
1075089006338	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1075089006339	putative substrate translocation pore; other site
1075089006340	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
1075089006341	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
1075089006342	NADP binding site [chemical binding]; other site
1075089006343	homopentamer interface [polypeptide binding]; other site
1075089006344	substrate binding site [chemical binding]; other site
1075089006345	active site
1075089006346	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1075089006347	intersubunit interface [polypeptide binding]; other site
1075089006348	active site
1075089006349	catalytic residue [active]
1075089006350	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
1075089006351	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1075089006352	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
1075089006353	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1075089006354	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1075089006355	dimerization interface [polypeptide binding]; other site
1075089006356	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1075089006357	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
1075089006358	catalytic triad [active]
1075089006359	dimer interface [polypeptide binding]; other site
1075089006360	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1075089006361	hypothetical protein; Provisional; Region: PRK02119
1075089006362	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1075089006363	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1075089006364	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1075089006365	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
1075089006366	YheO-like PAS domain; Region: PAS_6; pfam08348
1075089006367	HTH domain; Region: HTH_22; pfam13309
1075089006368	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
1075089006369	sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010
1075089006370	Uncharacterized conserved protein involved in oxidation of intracellular sulfur [Inorganic ion transport and metabolism]; Region: DsrH; COG2168
1075089006371	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1075089006372	S17 interaction site [polypeptide binding]; other site
1075089006373	S8 interaction site; other site
1075089006374	16S rRNA interaction site [nucleotide binding]; other site
1075089006375	streptomycin interaction site [chemical binding]; other site
1075089006376	23S rRNA interaction site [nucleotide binding]; other site
1075089006377	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1075089006378	30S ribosomal protein S7; Validated; Region: PRK05302
1075089006379	elongation factor G; Reviewed; Region: PRK00007
1075089006380	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1075089006381	G1 box; other site
1075089006382	putative GEF interaction site [polypeptide binding]; other site
1075089006383	GTP/Mg2+ binding site [chemical binding]; other site
1075089006384	Switch I region; other site
1075089006385	G2 box; other site
1075089006386	G3 box; other site
1075089006387	Switch II region; other site
1075089006388	G4 box; other site
1075089006389	G5 box; other site
1075089006390	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1075089006391	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1075089006392	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1075089006393	elongation factor Tu; Reviewed; Region: PRK00049
1075089006394	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1075089006395	G1 box; other site
1075089006396	GEF interaction site [polypeptide binding]; other site
1075089006397	GTP/Mg2+ binding site [chemical binding]; other site
1075089006398	Switch I region; other site
1075089006399	G2 box; other site
1075089006400	G3 box; other site
1075089006401	Switch II region; other site
1075089006402	G4 box; other site
1075089006403	G5 box; other site
1075089006404	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1075089006405	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1075089006406	Antibiotic Binding Site [chemical binding]; other site
1075089006407	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
1075089006408	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1075089006409	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1075089006410	putative homodimer interface [polypeptide binding]; other site
1075089006411	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1075089006412	heterodimer interface [polypeptide binding]; other site
1075089006413	homodimer interface [polypeptide binding]; other site
1075089006414	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1075089006415	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1075089006416	23S rRNA interface [nucleotide binding]; other site
1075089006417	L7/L12 interface [polypeptide binding]; other site
1075089006418	putative thiostrepton binding site; other site
1075089006419	L25 interface [polypeptide binding]; other site
1075089006420	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1075089006421	mRNA/rRNA interface [nucleotide binding]; other site
1075089006422	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1075089006423	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1075089006424	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1075089006425	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1075089006426	23S rRNA interface [nucleotide binding]; other site
1075089006427	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1075089006428	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1075089006429	core dimer interface [polypeptide binding]; other site
1075089006430	peripheral dimer interface [polypeptide binding]; other site
1075089006431	L10 interface [polypeptide binding]; other site
1075089006432	L11 interface [polypeptide binding]; other site
1075089006433	putative EF-Tu interaction site [polypeptide binding]; other site
1075089006434	putative EF-G interaction site [polypeptide binding]; other site
1075089006435	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1075089006436	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1075089006437	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1075089006438	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1075089006439	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
1075089006440	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1075089006441	RPB1 interaction site [polypeptide binding]; other site
1075089006442	RPB11 interaction site [polypeptide binding]; other site
1075089006443	RPB10 interaction site [polypeptide binding]; other site
1075089006444	RPB3 interaction site [polypeptide binding]; other site
1075089006445	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
1075089006446	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1075089006447	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1075089006448	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1075089006449	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1075089006450	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
1075089006451	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1075089006452	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1075089006453	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1075089006454	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1075089006455	DNA binding site [nucleotide binding]
1075089006456	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1075089006457	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
1075089006458	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
1075089006459	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
1075089006460	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1075089006461	putative NADH binding site [chemical binding]; other site
1075089006462	putative active site [active]
1075089006463	nudix motif; other site
1075089006464	putative metal binding site [ion binding]; other site
1075089006465	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1075089006466	substrate binding site [chemical binding]; other site
1075089006467	active site
1075089006468	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
1075089006469	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1075089006470	IHF dimer interface [polypeptide binding]; other site
1075089006471	IHF - DNA interface [nucleotide binding]; other site
1075089006472	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1075089006473	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1075089006474	glutaminase active site [active]
1075089006475	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1075089006476	dimer interface [polypeptide binding]; other site
1075089006477	active site
1075089006478	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1075089006479	dimer interface [polypeptide binding]; other site
1075089006480	active site
1075089006481	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
1075089006482	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
1075089006483	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
1075089006484	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1075089006485	dimer interface [polypeptide binding]; other site
1075089006486	conserved gate region; other site
1075089006487	ABC-ATPase subunit interface; other site
1075089006488	D-methionine ABC transporter, ATP-binding protein; Region: ABC_MetN; TIGR02314
1075089006489	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1075089006490	Walker A/P-loop; other site
1075089006491	ATP binding site [chemical binding]; other site
1075089006492	Q-loop/lid; other site
1075089006493	ABC transporter signature motif; other site
1075089006494	Walker B; other site
1075089006495	D-loop; other site
1075089006496	H-loop/switch region; other site
1075089006497	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1075089006498	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
1075089006499	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1075089006500	active site
1075089006501	motif I; other site
1075089006502	motif II; other site
1075089006503	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1075089006504	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
1075089006505	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
1075089006506	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
1075089006507	proline aminopeptidase P II; Provisional; Region: PRK10879
1075089006508	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
1075089006509	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1075089006510	active site
1075089006511	hypothetical protein; Reviewed; Region: PRK01736
1075089006512	Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division,    chromosome partitioning]; Region: zapA; COG3027
1075089006513	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1075089006514	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
1075089006515	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
1075089006516	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
1075089006517	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1075089006518	RNA binding surface [nucleotide binding]; other site
1075089006519	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1075089006520	active site
1075089006521	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1075089006522	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
1075089006523	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
1075089006524	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
1075089006525	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1075089006526	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1075089006527	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1075089006528	nucleotide binding pocket [chemical binding]; other site
1075089006529	K-X-D-G motif; other site
1075089006530	catalytic site [active]
1075089006531	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1075089006532	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1075089006533	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1075089006534	Dimer interface [polypeptide binding]; other site
1075089006535	N-acetylneuraminate lyase; Provisional; Region: PRK04147
1075089006536	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
1075089006537	inhibitor site; inhibition site
1075089006538	active site
1075089006539	dimer interface [polypeptide binding]; other site
1075089006540	catalytic residue [active]
1075089006541	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1075089006542	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1075089006543	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1075089006544	putative active site [active]
1075089006545	Domain of unknown function (DUF386); Region: DUF386; pfam04074
1075089006546	N-acetylmannosamine kinase; Provisional; Region: PRK05082
1075089006547	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1075089006548	nucleotide binding site [chemical binding]; other site
1075089006549	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
1075089006550	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
1075089006551	putative active site cavity [active]
1075089006552	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1075089006553	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1075089006554	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1075089006555	DctM-like transporters; Region: DctM; pfam06808
1075089006556	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
1075089006557	N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131
1075089006558	Kelch motif; Region: Kelch_1; pfam01344
1075089006559	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1075089006560	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1075089006561	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1075089006562	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1075089006563	catalytic residues [active]
1075089006564	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1075089006565	Clp amino terminal domain; Region: Clp_N; pfam02861
1075089006566	Clp amino terminal domain; Region: Clp_N; pfam02861
1075089006567	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1075089006568	Walker A motif; other site
1075089006569	ATP binding site [chemical binding]; other site
1075089006570	Walker B motif; other site
1075089006571	arginine finger; other site
1075089006572	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1075089006573	Walker A motif; other site
1075089006574	ATP binding site [chemical binding]; other site
1075089006575	Walker B motif; other site
1075089006576	arginine finger; other site
1075089006577	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1075089006578	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1075089006579	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1075089006580	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1075089006581	Protein of unknown function, DUF484; Region: DUF484; cl17449
1075089006582	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
1075089006583	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1075089006584	active site
1075089006585	Int/Topo IB signature motif; other site
1075089006586	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
1075089006587	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1075089006588	motif II; other site
1075089006589	SnoaL-like domain; Region: SnoaL_2; pfam12680
1075089006590	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1075089006591	EamA-like transporter family; Region: EamA; pfam00892
1075089006592	EamA-like transporter family; Region: EamA; pfam00892
1075089006593	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1075089006594	homooctamer interface [polypeptide binding]; other site
1075089006595	active site
1075089006596	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1075089006597	cell division protein ZipA; Provisional; Region: PRK01741
1075089006598	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
1075089006599	FtsZ protein binding site [polypeptide binding]; other site
1075089006600	putative sulfate transport protein CysZ; Validated; Region: PRK04949
1075089006601	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1075089006602	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1075089006603	dimer interface [polypeptide binding]; other site
1075089006604	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1075089006605	catalytic residue [active]
1075089006606	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
1075089006607	dimer interface [polypeptide binding]; other site
1075089006608	allosteric magnesium binding site [ion binding]; other site
1075089006609	active site
1075089006610	aspartate-rich active site metal binding site; other site
1075089006611	Schiff base residues; other site
1075089006612	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
1075089006613	sec-independent translocase; Provisional; Region: PRK01770
1075089006614	twin arginine translocase protein A; Provisional; Region: tatA; PRK01833
1075089006615	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
1075089006616	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
1075089006617	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
1075089006618	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1075089006619	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1075089006620	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089006621	S-adenosylmethionine binding site [chemical binding]; other site
1075089006622	Pirin-related protein [General function prediction only]; Region: COG1741
1075089006623	Pirin; Region: Pirin; pfam02678
1075089006624	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
1075089006625	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1075089006626	Sulfatase; Region: Sulfatase; pfam00884
1075089006627	Sulfatase; Region: Sulfatase; cl17466
1075089006628	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1075089006629	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
1075089006630	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
1075089006631	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1075089006632	membrane-bound complex binding site; other site
1075089006633	hinge residues; other site
1075089006634	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
1075089006635	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1075089006636	FeS/SAM binding site; other site
1075089006637	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1075089006638	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1075089006639	Domain of unknown function DUF21; Region: DUF21; pfam01595
1075089006640	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1075089006641	Transporter associated domain; Region: CorC_HlyC; smart01091
1075089006642	Protein of unknown function (DUF1523); Region: DUF1523; pfam07509
1075089006643	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1075089006644	active site
1075089006645	DNA polymerase III subunit delta'; Validated; Region: PRK06871
1075089006646	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1075089006647	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
1075089006648	thymidylate kinase; Validated; Region: tmk; PRK00698
1075089006649	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1075089006650	TMP-binding site; other site
1075089006651	ATP-binding site [chemical binding]; other site
1075089006652	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
1075089006653	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1075089006654	dimerization interface [polypeptide binding]; other site
1075089006655	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
1075089006656	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
1075089006657	ligand binding site [chemical binding]; other site
1075089006658	NAD binding site [chemical binding]; other site
1075089006659	tetramer interface [polypeptide binding]; other site
1075089006660	catalytic site [active]
1075089006661	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
1075089006662	L-serine binding site [chemical binding]; other site
1075089006663	ACT domain interface; other site
1075089006664	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1075089006665	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1075089006666	active site
1075089006667	dimer interface [polypeptide binding]; other site
1075089006668	HemN family oxidoreductase; Provisional; Region: PRK05660
1075089006669	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1075089006670	FeS/SAM binding site; other site
1075089006671	HemN C-terminal domain; Region: HemN_C; pfam06969
1075089006672	Uncharacterized conserved protein [Function unknown]; Region: COG0393
1075089006673	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1075089006674	active site
1075089006675	dimerization interface [polypeptide binding]; other site
1075089006676	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1075089006677	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1075089006678	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1075089006679	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1075089006680	lipoprotein signal peptidase; Provisional; Region: PRK14787
1075089006681	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1075089006682	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1075089006683	active site
1075089006684	HIGH motif; other site
1075089006685	nucleotide binding site [chemical binding]; other site
1075089006686	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1075089006687	active site
1075089006688	KMSKS motif; other site
1075089006689	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1075089006690	tRNA binding surface [nucleotide binding]; other site
1075089006691	anticodon binding site; other site
1075089006692	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1075089006693	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1075089006694	active site
1075089006695	Riboflavin kinase; Region: Flavokinase; smart00904
1075089006696	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1075089006697	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1075089006698	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1075089006699	Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726
1075089006700	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
1075089006701	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1075089006702	motif II; other site
1075089006703	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1075089006704	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1075089006705	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
1075089006706	DctM-like transporters; Region: DctM; pfam06808
1075089006707	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1075089006708	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1075089006709	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1075089006710	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1075089006711	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
1075089006712	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1075089006713	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
1075089006714	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1075089006715	DAK2 domain; Region: Dak2; pfam02734
1075089006716	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1075089006717	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1075089006718	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1075089006719	DNA binding residues [nucleotide binding]
1075089006720	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1075089006721	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
1075089006722	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1075089006723	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1075089006724	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1075089006725	DctM-like transporters; Region: DctM; pfam06808
1075089006726	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1075089006727	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1075089006728	triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; Provisional; Region: PRK14905
1075089006729	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1075089006730	substrate binding site [chemical binding]; other site
1075089006731	dimer interface [polypeptide binding]; other site
1075089006732	catalytic triad [active]
1075089006733	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1075089006734	active site turn [active]
1075089006735	phosphorylation site [posttranslational modification]
1075089006736	transaldolase-like protein; Provisional; Region: PTZ00411
1075089006737	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
1075089006738	active site
1075089006739	dimer interface [polypeptide binding]; other site
1075089006740	catalytic residue [active]
1075089006741	transketolase; Reviewed; Region: PRK12753
1075089006742	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1075089006743	TPP-binding site [chemical binding]; other site
1075089006744	dimer interface [polypeptide binding]; other site
1075089006745	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1075089006746	PYR/PP interface [polypeptide binding]; other site
1075089006747	dimer interface [polypeptide binding]; other site
1075089006748	TPP binding site [chemical binding]; other site
1075089006749	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1075089006750	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
1075089006751	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1075089006752	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1075089006753	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
1075089006754	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1075089006755	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1075089006756	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1075089006757	DNA binding residues [nucleotide binding]
1075089006758	DNA primase; Validated; Region: dnaG; PRK05667
1075089006759	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1075089006760	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1075089006761	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1075089006762	active site
1075089006763	metal binding site [ion binding]; metal-binding site
1075089006764	interdomain interaction site; other site
1075089006765	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1075089006766	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
1075089006767	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1075089006768	UGMP family protein; Validated; Region: PRK09604
1075089006769	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1075089006770	thymidine kinase; Provisional; Region: PRK04296
1075089006771	glutathione reductase; Validated; Region: PRK06116
1075089006772	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1075089006773	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1075089006774	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1075089006775	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
1075089006776	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1075089006777	predicted active site [active]
1075089006778	catalytic triad [active]
1075089006779	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1075089006780	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1075089006781	active site
1075089006782	multimer interface [polypeptide binding]; other site
1075089006783	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1075089006784	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1075089006785	DNA-binding site [nucleotide binding]; DNA binding site
1075089006786	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1075089006787	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1075089006788	homodimer interface [polypeptide binding]; other site
1075089006789	catalytic residue [active]
1075089006790	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
1075089006791	Transglycosylase; Region: Transgly; pfam00912
1075089006792	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1075089006793	Competence protein A; Region: Competence_A; pfam11104
1075089006794	Pilus assembly protein, PilP; Region: PilP; pfam04351
1075089006795	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
1075089006796	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1075089006797	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1075089006798	shikimate kinase; Reviewed; Region: aroK; PRK00131
1075089006799	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1075089006800	ADP binding site [chemical binding]; other site
1075089006801	magnesium binding site [ion binding]; other site
1075089006802	putative shikimate binding site; other site
1075089006803	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1075089006804	active site
1075089006805	dimer interface [polypeptide binding]; other site
1075089006806	metal binding site [ion binding]; metal-binding site
1075089006807	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
1075089006808	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4701
1075089006809	Protein of unknown function (DUF2547); Region: DUF2547; pfam10818
1075089006810	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1075089006811	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1075089006812	SEC-C motif; Region: SEC-C; pfam02810
1075089006813	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1075089006814	active site
1075089006815	8-oxo-dGMP binding site [chemical binding]; other site
1075089006816	nudix motif; other site
1075089006817	metal binding site [ion binding]; metal-binding site
1075089006818	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1075089006819	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1075089006820	Rare lipoprotein B [Cell envelope biogenesis, outer membrane]; Region: RlpB; COG2980
1075089006821	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1075089006822	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1075089006823	HIGH motif; other site
1075089006824	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1075089006825	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1075089006826	active site
1075089006827	KMSKS motif; other site
1075089006828	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1075089006829	tRNA binding surface [nucleotide binding]; other site
1075089006830	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
1075089006831	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1075089006832	N-terminal plug; other site
1075089006833	ligand-binding site [chemical binding]; other site
1075089006834	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
1075089006835	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1075089006836	active site
1075089006837	DNA binding site [nucleotide binding]
1075089006838	Int/Topo IB signature motif; other site
1075089006839	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1075089006840	metal-binding site [ion binding]
1075089006841	MerT mercuric transport protein; Region: MerT; cl03578
1075089006842	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1075089006843	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1075089006844	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
1075089006845	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
1075089006846	active site
1075089006847	metal binding site [ion binding]; metal-binding site
1075089006848	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1075089006849	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
1075089006850	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1075089006851	SurA N-terminal domain; Region: SurA_N; pfam09312
1075089006852	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1075089006853	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1075089006854	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1075089006855	active site
1075089006856	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1075089006857	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
1075089006858	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1075089006859	metal binding site [ion binding]; metal-binding site
1075089006860	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1075089006861	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1075089006862	substrate binding site [chemical binding]; other site
1075089006863	glutamase interaction surface [polypeptide binding]; other site
1075089006864	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1075089006865	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1075089006866	catalytic residues [active]
1075089006867	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
1075089006868	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1075089006869	putative active site [active]
1075089006870	oxyanion strand; other site
1075089006871	catalytic triad [active]
1075089006872	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
1075089006873	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1075089006874	active site
1075089006875	motif I; other site
1075089006876	motif II; other site
1075089006877	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1075089006878	putative active site pocket [active]
1075089006879	4-fold oligomerization interface [polypeptide binding]; other site
1075089006880	metal binding residues [ion binding]; metal-binding site
1075089006881	3-fold/trimer interface [polypeptide binding]; other site
1075089006882	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
1075089006883	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1075089006884	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1075089006885	homodimer interface [polypeptide binding]; other site
1075089006886	catalytic residue [active]
1075089006887	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
1075089006888	Fic/DOC family; Region: Fic; pfam02661
1075089006889	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1075089006890	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1075089006891	NAD binding site [chemical binding]; other site
1075089006892	dimerization interface [polypeptide binding]; other site
1075089006893	product binding site; other site
1075089006894	substrate binding site [chemical binding]; other site
1075089006895	zinc binding site [ion binding]; other site
1075089006896	catalytic residues [active]
1075089006897	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1075089006898	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1075089006899	trimer interface [polypeptide binding]; other site
1075089006900	active site
1075089006901	substrate binding site [chemical binding]; other site
1075089006902	CoA binding site [chemical binding]; other site
1075089006903	Y-family of DNA polymerases; Region: PolY; cl12025
1075089006904	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
1075089006905	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
1075089006906	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
1075089006907	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1075089006908	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1075089006909	S-adenosylmethionine binding site [chemical binding]; other site
1075089006910	aromatic amino acid transport protein; Region: araaP; TIGR00837
1075089006911	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1075089006912	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1075089006913	dimer interface [polypeptide binding]; other site
1075089006914	substrate binding site [chemical binding]; other site
1075089006915	metal binding sites [ion binding]; metal-binding site
1075089006916	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1075089006917	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1075089006918	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
1075089006919	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1075089006920	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
1075089006921	tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805
1075089006922	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
1075089006923	Domain of unknown function DUF21; Region: DUF21; pfam01595
1075089006924	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1075089006925	Transporter associated domain; Region: CorC_HlyC; smart01091
1075089006926	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
1075089006927	signal recognition particle protein; Provisional; Region: PRK10867
1075089006928	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1075089006929	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1075089006930	P loop; other site
1075089006931	GTP binding site [chemical binding]; other site
1075089006932	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1075089006933	Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937
1075089006934	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
1075089006935	putative acyl-acceptor binding pocket; other site
1075089006936	LexA repressor; Validated; Region: PRK00215
1075089006937	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1075089006938	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1075089006939	Catalytic site [active]
1075089006940	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1075089006941	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1075089006942	dimer interface [polypeptide binding]; other site
1075089006943	ssDNA binding site [nucleotide binding]; other site
1075089006944	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1075089006945	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1075089006946	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1075089006947	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1075089006948	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1075089006949	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604
1075089006950	glutamine synthetase; Provisional; Region: glnA; PRK09469
1075089006951	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1075089006952	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1075089006953	Alpha-2,3-sialyltransferase (CST-I); Region: CST-I; pfam06002
1075089006954	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1075089006955	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1075089006956	G1 box; other site
1075089006957	putative GEF interaction site [polypeptide binding]; other site
1075089006958	GTP/Mg2+ binding site [chemical binding]; other site
1075089006959	Switch I region; other site
1075089006960	G2 box; other site
1075089006961	G3 box; other site
1075089006962	Switch II region; other site
1075089006963	G4 box; other site
1075089006964	G5 box; other site
1075089006965	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1075089006966	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1075089006967	Uncharacterized integral membrane protein [Function unknown]; Region: COG3739
1075089006968	Periplasmic protein with OB-fold [Function unknown]; Region: COG3111
1075089006969	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
1075089006970	homodimer interaction site [polypeptide binding]; other site
1075089006971	cofactor binding site; other site
1075089006972	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1075089006973	UbiA prenyltransferase family; Region: UbiA; pfam01040
1075089006974	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
1075089006975	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1075089006976	transmembrane helices; other site
1075089006977	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1075089006978	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1075089006979	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1075089006980	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1075089006981	G1 box; other site
1075089006982	GTP/Mg2+ binding site [chemical binding]; other site
1075089006983	Switch I region; other site
1075089006984	G2 box; other site
1075089006985	Switch II region; other site
1075089006986	G3 box; other site
1075089006987	G4 box; other site
1075089006988	G5 box; other site
1075089006989	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1075089006990	membrane protein insertase; Provisional; Region: PRK01318
1075089006991	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1075089006992	hypothetical protein; Validated; Region: PRK00041
1075089006993	ribonuclease P; Reviewed; Region: rnpA; PRK01732
1075089006994	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399