-- dump date 20140619_231822 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1132496000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1132496000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1132496000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1132496000004 Walker A motif; other site 1132496000005 ATP binding site [chemical binding]; other site 1132496000006 Walker B motif; other site 1132496000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1132496000008 arginine finger; other site 1132496000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1132496000010 DnaA box-binding interface [nucleotide binding]; other site 1132496000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 1132496000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1132496000013 putative DNA binding surface [nucleotide binding]; other site 1132496000014 dimer interface [polypeptide binding]; other site 1132496000015 beta-clamp/clamp loader binding surface; other site 1132496000016 beta-clamp/translesion DNA polymerase binding surface; other site 1132496000017 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 1132496000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496000019 Walker A/P-loop; other site 1132496000020 ATP binding site [chemical binding]; other site 1132496000021 Q-loop/lid; other site 1132496000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496000023 ABC transporter signature motif; other site 1132496000024 Walker B; other site 1132496000025 D-loop; other site 1132496000026 H-loop/switch region; other site 1132496000027 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1132496000028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496000029 S-adenosylmethionine binding site [chemical binding]; other site 1132496000030 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1132496000031 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1132496000032 ligand binding site [chemical binding]; other site 1132496000033 flexible hinge region; other site 1132496000034 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1132496000035 putative switch regulator; other site 1132496000036 non-specific DNA interactions [nucleotide binding]; other site 1132496000037 DNA binding site [nucleotide binding] 1132496000038 sequence specific DNA binding site [nucleotide binding]; other site 1132496000039 putative cAMP binding site [chemical binding]; other site 1132496000040 hypothetical protein; Provisional; Region: PRK04966 1132496000041 division inhibitor protein; Provisional; Region: slmA; PRK09480 1132496000042 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1132496000043 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1132496000044 trimer interface [polypeptide binding]; other site 1132496000045 active site 1132496000046 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1132496000047 Flavoprotein; Region: Flavoprotein; pfam02441 1132496000048 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1132496000049 hypothetical protein; Reviewed; Region: PRK00024 1132496000050 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1132496000051 MPN+ (JAMM) motif; other site 1132496000052 Zinc-binding site [ion binding]; other site 1132496000053 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1132496000054 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1132496000055 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1132496000056 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1132496000057 putative ligand binding residues [chemical binding]; other site 1132496000058 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1132496000059 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1132496000060 ABC-ATPase subunit interface; other site 1132496000061 dimer interface [polypeptide binding]; other site 1132496000062 putative PBP binding regions; other site 1132496000063 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1132496000064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496000065 Walker A/P-loop; other site 1132496000066 ATP binding site [chemical binding]; other site 1132496000067 Q-loop/lid; other site 1132496000068 ABC transporter signature motif; other site 1132496000069 Walker B; other site 1132496000070 D-loop; other site 1132496000071 H-loop/switch region; other site 1132496000072 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1132496000073 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 1132496000074 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1132496000075 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1132496000076 DNA binding site [nucleotide binding] 1132496000077 putative catalytic residues [active] 1132496000078 turnover-facilitating residue; other site 1132496000079 intercalation triad [nucleotide binding]; other site 1132496000080 8OG recognition residue [nucleotide binding]; other site 1132496000081 putative reading head residues; other site 1132496000082 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1132496000083 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1132496000084 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1132496000085 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1132496000086 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 1132496000087 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1132496000088 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 1132496000089 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1132496000090 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1132496000091 active site 1132496000092 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1132496000093 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1132496000094 active site 1132496000095 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1132496000096 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1132496000097 Ligand binding site; other site 1132496000098 metal-binding site 1132496000099 primosome assembly protein PriA; Validated; Region: PRK05580 1132496000100 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1132496000101 ATP binding site [chemical binding]; other site 1132496000102 putative Mg++ binding site [ion binding]; other site 1132496000103 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1132496000104 ATP-binding site [chemical binding]; other site 1132496000105 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 1132496000106 Sporulation related domain; Region: SPOR; pfam05036 1132496000107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1132496000108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1132496000109 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1132496000110 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1132496000111 HlyD family secretion protein; Region: HlyD_3; pfam13437 1132496000112 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1132496000113 GAF domain; Region: GAF_2; pfam13185 1132496000114 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1132496000115 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1132496000116 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1132496000117 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1132496000118 ArsC family; Region: ArsC; pfam03960 1132496000119 catalytic residues [active] 1132496000120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 1132496000121 argininosuccinate lyase; Provisional; Region: PRK04833 1132496000122 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1132496000123 active sites [active] 1132496000124 tetramer interface [polypeptide binding]; other site 1132496000125 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1132496000126 nucleotide binding site [chemical binding]; other site 1132496000127 N-acetyl-L-glutamate binding site [chemical binding]; other site 1132496000128 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1132496000129 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1132496000130 acetylornithine deacetylase; Provisional; Region: PRK05111 1132496000131 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1132496000132 metal binding site [ion binding]; metal-binding site 1132496000133 putative dimer interface [polypeptide binding]; other site 1132496000134 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 1132496000135 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1132496000136 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1132496000137 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1132496000138 HIGH motif; other site 1132496000139 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1132496000140 active site 1132496000141 KMSKS motif; other site 1132496000142 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1132496000143 active site 1132496000144 DNA binding site [nucleotide binding] 1132496000145 Int/Topo IB signature motif; other site 1132496000146 Protein of unknown function (DUF551); Region: DUF551; pfam04448 1132496000147 Putative exonuclease, RdgC; Region: RdgC; pfam04381 1132496000148 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u3; cd11540 1132496000149 putative metal binding site [ion binding]; other site 1132496000150 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1132496000151 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1132496000152 dimer interface [polypeptide binding]; other site 1132496000153 ssDNA binding site [nucleotide binding]; other site 1132496000154 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1132496000155 ERF superfamily; Region: ERF; pfam04404 1132496000156 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1132496000157 active site 1132496000158 catalytic site [active] 1132496000159 substrate binding site [chemical binding]; other site 1132496000160 Prophage antirepressor [Transcription]; Region: COG3617 1132496000161 BRO family, N-terminal domain; Region: Bro-N; smart01040 1132496000162 KilA-N domain; Region: KilA-N; pfam04383 1132496000163 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 1132496000164 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1132496000165 non-specific DNA binding site [nucleotide binding]; other site 1132496000166 salt bridge; other site 1132496000167 sequence-specific DNA binding site [nucleotide binding]; other site 1132496000168 Predicted transcriptional regulator [Transcription]; Region: COG2932 1132496000169 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1132496000170 Catalytic site [active] 1132496000171 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1132496000172 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1132496000173 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1132496000174 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1132496000175 active site 1132496000176 Helix-turn-helix domain; Region: HTH_36; pfam13730 1132496000177 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1132496000178 Replication protein P; Region: Phage_lambda_P; pfam06992 1132496000179 MT-A70; Region: MT-A70; cl01947 1132496000180 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 1132496000181 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1132496000182 KilA-N domain; Region: KilA-N; pfam04383 1132496000183 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1132496000184 catalytic residues [active] 1132496000185 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 1132496000186 Homeodomain-like domain; Region: HTH_23; pfam13384 1132496000187 Phage terminase large subunit; Region: Terminase_3; cl12054 1132496000188 Terminase-like family; Region: Terminase_6; pfam03237 1132496000189 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 1132496000190 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1132496000191 Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804 1132496000192 Phage major tail protein 2; Region: Phage_tail_2; cl11463 1132496000193 TM2 domain; Region: TM2; pfam05154 1132496000194 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1132496000195 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 1132496000196 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 1132496000197 Phage minor tail protein; Region: Phage_min_tail; cl01940 1132496000198 Phage-related protein [Function unknown]; Region: gp18; COG4672 1132496000199 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1132496000200 MPN+ (JAMM) motif; other site 1132496000201 Zinc-binding site [ion binding]; other site 1132496000202 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1132496000203 NlpC/P60 family; Region: NLPC_P60; cl17555 1132496000204 Phage-related protein, tail component [Function unknown]; Region: COG4723 1132496000205 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1132496000206 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1132496000207 RNase E interface [polypeptide binding]; other site 1132496000208 trimer interface [polypeptide binding]; other site 1132496000209 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1132496000210 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1132496000211 RNase E interface [polypeptide binding]; other site 1132496000212 trimer interface [polypeptide binding]; other site 1132496000213 active site 1132496000214 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1132496000215 putative nucleic acid binding region [nucleotide binding]; other site 1132496000216 G-X-X-G motif; other site 1132496000217 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1132496000218 RNA binding site [nucleotide binding]; other site 1132496000219 domain interface; other site 1132496000220 Lipoprotein NlpI, contains TPR repeats [General function prediction only]; Region: NlpI; COG4785 1132496000221 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1132496000222 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1132496000223 ATP binding site [chemical binding]; other site 1132496000224 Mg++ binding site [ion binding]; other site 1132496000225 motif III; other site 1132496000226 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1132496000227 nucleotide binding region [chemical binding]; other site 1132496000228 ATP-binding site [chemical binding]; other site 1132496000229 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1132496000230 putative RNA binding site [nucleotide binding]; other site 1132496000231 molybdenum transport protein ModD; Provisional; Region: PRK06096 1132496000232 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 1132496000233 dimerization interface [polypeptide binding]; other site 1132496000234 active site 1132496000235 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1132496000236 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496000237 Walker A/P-loop; other site 1132496000238 ATP binding site [chemical binding]; other site 1132496000239 Q-loop/lid; other site 1132496000240 ABC transporter signature motif; other site 1132496000241 Walker B; other site 1132496000242 D-loop; other site 1132496000243 H-loop/switch region; other site 1132496000244 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1132496000245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496000246 putative PBP binding loops; other site 1132496000247 ABC-ATPase subunit interface; other site 1132496000248 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1132496000249 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1132496000250 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1132496000251 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1132496000252 ring oligomerisation interface [polypeptide binding]; other site 1132496000253 ATP/Mg binding site [chemical binding]; other site 1132496000254 stacking interactions; other site 1132496000255 hinge regions; other site 1132496000256 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1132496000257 oligomerisation interface [polypeptide binding]; other site 1132496000258 mobile loop; other site 1132496000259 roof hairpin; other site 1132496000260 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1132496000261 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 1132496000262 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1132496000263 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1132496000264 Aspartase; Region: Aspartase; cd01357 1132496000265 active sites [active] 1132496000266 tetramer interface [polypeptide binding]; other site 1132496000267 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1132496000268 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1132496000269 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1132496000270 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1132496000271 putative C-terminal domain interface [polypeptide binding]; other site 1132496000272 putative GSH binding site (G-site) [chemical binding]; other site 1132496000273 putative dimer interface [polypeptide binding]; other site 1132496000274 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1132496000275 dimer interface [polypeptide binding]; other site 1132496000276 N-terminal domain interface [polypeptide binding]; other site 1132496000277 putative substrate binding pocket (H-site) [chemical binding]; other site 1132496000278 Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545 1132496000279 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1132496000280 dimer interface [polypeptide binding]; other site 1132496000281 motif 1; other site 1132496000282 active site 1132496000283 motif 2; other site 1132496000284 motif 3; other site 1132496000285 Predicted membrane protein [Function unknown]; Region: COG4325 1132496000286 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1132496000287 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1132496000288 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1132496000289 substrate binding site [chemical binding]; other site 1132496000290 oxyanion hole (OAH) forming residues; other site 1132496000291 trimer interface [polypeptide binding]; other site 1132496000292 O-succinylbenzoate synthase [Coenzyme metabolism]; Region: MenC; COG1441 1132496000293 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1132496000294 active site 1132496000295 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1132496000296 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1132496000297 active site 1132496000298 trimer interface [polypeptide binding]; other site 1132496000299 dimer interface [polypeptide binding]; other site 1132496000300 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1132496000301 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1132496000302 carboxyltransferase (CT) interaction site; other site 1132496000303 biotinylation site [posttranslational modification]; other site 1132496000304 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1132496000305 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1132496000306 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1132496000307 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1132496000308 Predicted membrane protein [Function unknown]; Region: COG3924 1132496000309 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1132496000310 Na binding site [ion binding]; other site 1132496000311 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1132496000312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496000313 S-adenosylmethionine binding site [chemical binding]; other site 1132496000314 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1132496000315 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1132496000316 FMN binding site [chemical binding]; other site 1132496000317 active site 1132496000318 catalytic residues [active] 1132496000319 substrate binding site [chemical binding]; other site 1132496000320 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1132496000321 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1132496000322 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1132496000323 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1132496000324 dimerization interface [polypeptide binding]; other site 1132496000325 ATP binding site [chemical binding]; other site 1132496000326 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1132496000327 dimerization interface [polypeptide binding]; other site 1132496000328 ATP binding site [chemical binding]; other site 1132496000329 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1132496000330 putative active site [active] 1132496000331 catalytic triad [active] 1132496000332 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1132496000333 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1132496000334 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1132496000335 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1132496000336 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1132496000337 Walker A/P-loop; other site 1132496000338 ATP binding site [chemical binding]; other site 1132496000339 Q-loop/lid; other site 1132496000340 ABC transporter signature motif; other site 1132496000341 Walker B; other site 1132496000342 D-loop; other site 1132496000343 H-loop/switch region; other site 1132496000344 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1132496000345 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1132496000346 dimer interface [polypeptide binding]; other site 1132496000347 ABC-ATPase subunit interface; other site 1132496000348 putative PBP binding regions; other site 1132496000349 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1132496000350 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1132496000351 intersubunit interface [polypeptide binding]; other site 1132496000352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3021 1132496000353 putative catalytic site [active] 1132496000354 putative metal binding site [ion binding]; other site 1132496000355 putative phosphate binding site [ion binding]; other site 1132496000356 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1132496000357 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1132496000358 active site 1132496000359 substrate binding site [chemical binding]; other site 1132496000360 metal binding site [ion binding]; metal-binding site 1132496000361 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1132496000362 ABC transporter transmembrane region 2; Region: ABC_membrane_2; pfam06472 1132496000363 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1132496000364 putative transporter; Validated; Region: PRK03818 1132496000365 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1132496000366 TrkA-C domain; Region: TrkA_C; pfam02080 1132496000367 TrkA-C domain; Region: TrkA_C; pfam02080 1132496000368 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1132496000369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1132496000370 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1132496000371 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1132496000372 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1132496000373 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1132496000374 DNA binding site [nucleotide binding] 1132496000375 active site 1132496000376 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1132496000377 putative DNA-binding cleft [nucleotide binding]; other site 1132496000378 putative DNA clevage site; other site 1132496000379 molecular lever; other site 1132496000380 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1132496000381 DNA polymerase I; Provisional; Region: PRK05755 1132496000382 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1132496000383 active site 1132496000384 metal binding site 1 [ion binding]; metal-binding site 1132496000385 putative 5' ssDNA interaction site; other site 1132496000386 metal binding site 3; metal-binding site 1132496000387 metal binding site 2 [ion binding]; metal-binding site 1132496000388 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1132496000389 putative DNA binding site [nucleotide binding]; other site 1132496000390 putative metal binding site [ion binding]; other site 1132496000391 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1132496000392 active site 1132496000393 catalytic site [active] 1132496000394 substrate binding site [chemical binding]; other site 1132496000395 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1132496000396 active site 1132496000397 DNA binding site [nucleotide binding] 1132496000398 catalytic site [active] 1132496000399 Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503 1132496000400 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1132496000401 Mannitol repressor; Region: MtlR; pfam05068 1132496000402 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1132496000403 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1132496000404 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1132496000405 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1132496000406 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1132496000407 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1132496000408 active site 1132496000409 P-loop; other site 1132496000410 phosphorylation site [posttranslational modification] 1132496000411 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1132496000412 active site 1132496000413 phosphorylation site [posttranslational modification] 1132496000414 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5645 1132496000415 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 1132496000416 Part of AAA domain; Region: AAA_19; pfam13245 1132496000417 Family description; Region: UvrD_C_2; pfam13538 1132496000418 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1132496000419 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1132496000420 motif II; other site 1132496000421 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1132496000422 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1132496000423 active site 1132496000424 substrate binding site [chemical binding]; other site 1132496000425 trimer interface [polypeptide binding]; other site 1132496000426 CoA binding site [chemical binding]; other site 1132496000427 Predicted membrane protein [Function unknown]; Region: COG1238 1132496000428 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1132496000429 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1132496000430 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1132496000431 ATP-grasp domain; Region: ATP-grasp; pfam02222 1132496000432 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1132496000433 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1132496000434 catalytic triad [active] 1132496000435 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1132496000436 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1132496000437 dimer interface [polypeptide binding]; other site 1132496000438 active site 1132496000439 catalytic residue [active] 1132496000440 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 1132496000441 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1132496000442 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1132496000443 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1132496000444 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 1132496000445 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1132496000446 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1132496000447 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1132496000448 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1132496000449 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1132496000450 PhoH-like protein; Region: PhoH; pfam02562 1132496000451 metal-binding heat shock protein; Provisional; Region: PRK00016 1132496000452 phosphodiesterase; Provisional; Region: PRK12704 1132496000453 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1132496000454 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 1132496000455 Helicase; Region: Helicase_RecD; pfam05127 1132496000456 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1132496000457 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1132496000458 putative metal dependent hydrolase; Provisional; Region: PRK11598 1132496000459 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1132496000460 Sulfatase; Region: Sulfatase; pfam00884 1132496000461 transcription-repair coupling factor; Provisional; Region: PRK10689 1132496000462 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1132496000463 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1132496000464 ATP binding site [chemical binding]; other site 1132496000465 putative Mg++ binding site [ion binding]; other site 1132496000466 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1132496000467 nucleotide binding region [chemical binding]; other site 1132496000468 ATP-binding site [chemical binding]; other site 1132496000469 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1132496000470 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1132496000471 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1132496000472 TM-ABC transporter signature motif; other site 1132496000473 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1132496000474 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 1132496000475 Walker A/P-loop; other site 1132496000476 ATP binding site [chemical binding]; other site 1132496000477 Q-loop/lid; other site 1132496000478 ABC transporter signature motif; other site 1132496000479 Walker B; other site 1132496000480 D-loop; other site 1132496000481 H-loop/switch region; other site 1132496000482 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1132496000483 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1132496000484 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1132496000485 ligand binding site [chemical binding]; other site 1132496000486 calcium binding site [ion binding]; other site 1132496000487 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 1132496000488 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1132496000489 DNA binding site [nucleotide binding] 1132496000490 domain linker motif; other site 1132496000491 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1132496000492 ligand binding site [chemical binding]; other site 1132496000493 dimerization interface (closed form) [polypeptide binding]; other site 1132496000494 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1132496000495 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1132496000496 dimer interface [polypeptide binding]; other site 1132496000497 active site 1132496000498 galactokinase; Provisional; Region: PRK05101 1132496000499 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1132496000500 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1132496000501 active site 1132496000502 catalytic residues [active] 1132496000503 FOG: CBS domain [General function prediction only]; Region: COG0517 1132496000504 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1132496000505 Transporter associated domain; Region: CorC_HlyC; smart01091 1132496000506 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1132496000507 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1132496000508 putative active site [active] 1132496000509 catalytic triad [active] 1132496000510 putative dimer interface [polypeptide binding]; other site 1132496000511 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1132496000512 rRNA binding site [nucleotide binding]; other site 1132496000513 predicted 30S ribosome binding site; other site 1132496000514 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1132496000515 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1132496000516 NAD binding site [chemical binding]; other site 1132496000517 substrate binding site [chemical binding]; other site 1132496000518 homodimer interface [polypeptide binding]; other site 1132496000519 active site 1132496000520 aminopeptidase B; Provisional; Region: PRK05015 1132496000521 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1132496000522 interface (dimer of trimers) [polypeptide binding]; other site 1132496000523 Substrate-binding/catalytic site; other site 1132496000524 Zn-binding sites [ion binding]; other site 1132496000525 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1132496000526 active site 1132496000527 multimer interface [polypeptide binding]; other site 1132496000528 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1132496000529 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1132496000530 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1132496000531 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1132496000532 hypothetical protein; Provisional; Region: PRK04860 1132496000533 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1132496000534 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1132496000535 heat shock protein 90; Provisional; Region: PRK05218 1132496000536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1132496000537 ATP binding site [chemical binding]; other site 1132496000538 Mg2+ binding site [ion binding]; other site 1132496000539 G-X-G motif; other site 1132496000540 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1132496000541 ArsC family; Region: ArsC; pfam03960 1132496000542 putative catalytic residues [active] 1132496000543 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1132496000544 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1132496000545 metal binding site [ion binding]; metal-binding site 1132496000546 dimer interface [polypeptide binding]; other site 1132496000547 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1132496000548 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1132496000549 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1132496000550 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1132496000551 dimer interface [polypeptide binding]; other site 1132496000552 ADP-ribose binding site [chemical binding]; other site 1132496000553 active site 1132496000554 nudix motif; other site 1132496000555 metal binding site [ion binding]; metal-binding site 1132496000556 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1132496000557 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1132496000558 active site 1132496000559 metal binding site [ion binding]; metal-binding site 1132496000560 hexamer interface [polypeptide binding]; other site 1132496000561 tyrosine kinase; Provisional; Region: PRK11519 1132496000562 Chain length determinant protein; Region: Wzz; pfam02706 1132496000563 Chain length determinant protein; Region: Wzz; cl15801 1132496000564 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1132496000565 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1132496000566 P loop; other site 1132496000567 Nucleotide binding site [chemical binding]; other site 1132496000568 DTAP/Switch II; other site 1132496000569 Switch I; other site 1132496000570 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1132496000571 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1132496000572 active site 1132496000573 polysaccharide export protein Wza; Provisional; Region: PRK15078 1132496000574 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1132496000575 SLBB domain; Region: SLBB; pfam10531 1132496000576 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1132496000577 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1132496000578 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1132496000579 NAD(P) binding site [chemical binding]; other site 1132496000580 homodimer interface [polypeptide binding]; other site 1132496000581 substrate binding site [chemical binding]; other site 1132496000582 active site 1132496000583 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1132496000584 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1132496000585 inhibitor-cofactor binding pocket; inhibition site 1132496000586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1132496000587 catalytic residue [active] 1132496000588 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1132496000589 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1132496000590 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1132496000591 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1132496000592 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1132496000593 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1132496000594 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1132496000595 active site 1132496000596 homodimer interface [polypeptide binding]; other site 1132496000597 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1132496000598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1132496000599 NAD(P) binding site [chemical binding]; other site 1132496000600 active site 1132496000601 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1132496000602 UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130 1132496000603 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1132496000604 NAD(P) binding site [chemical binding]; other site 1132496000605 homodimer interface [polypeptide binding]; other site 1132496000606 substrate binding site [chemical binding]; other site 1132496000607 active site 1132496000608 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 1132496000609 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1132496000610 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1132496000611 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1132496000612 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1132496000613 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 1132496000614 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1132496000615 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1132496000616 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1132496000617 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1132496000618 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1132496000619 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1132496000620 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1132496000621 FeS/SAM binding site; other site 1132496000622 TRAM domain; Region: TRAM; pfam01938 1132496000623 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 1132496000624 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1132496000625 catalytic site [active] 1132496000626 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1132496000627 Asp-box motif; other site 1132496000628 Asp-box motif; other site 1132496000629 catalytic site [active] 1132496000630 Autotransporter beta-domain; Region: Autotransporter; smart00869 1132496000631 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 1132496000632 Nicotinate phosphoribosyltransferase (NAPRTase) family; Region: NAPRTase; pfam04095 1132496000633 active site 1132496000634 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1132496000635 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1132496000636 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1132496000637 HlyD family secretion protein; Region: HlyD_3; pfam13437 1132496000638 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1132496000639 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1132496000640 Walker A/P-loop; other site 1132496000641 ATP binding site [chemical binding]; other site 1132496000642 Q-loop/lid; other site 1132496000643 ABC transporter signature motif; other site 1132496000644 Walker B; other site 1132496000645 D-loop; other site 1132496000646 H-loop/switch region; other site 1132496000647 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1132496000648 FtsX-like permease family; Region: FtsX; pfam02687 1132496000649 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1132496000650 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1132496000651 homodimer interface [polypeptide binding]; other site 1132496000652 substrate-cofactor binding pocket; other site 1132496000653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1132496000654 catalytic residue [active] 1132496000655 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1132496000656 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1132496000657 catalytic residues [active] 1132496000658 NAD-dependent deacetylase; Provisional; Region: PRK00481 1132496000659 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1132496000660 NAD+ binding site [chemical binding]; other site 1132496000661 substrate binding site [chemical binding]; other site 1132496000662 Zn binding site [ion binding]; other site 1132496000663 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1132496000664 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1132496000665 RNA binding surface [nucleotide binding]; other site 1132496000666 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1132496000667 active site 1132496000668 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1132496000669 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1132496000670 homodimer interface [polypeptide binding]; other site 1132496000671 oligonucleotide binding site [chemical binding]; other site 1132496000672 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1132496000673 Primosomal replication protein N'' [DNA replication, recombination, and repair]; Region: PriC; COG3923 1132496000674 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1132496000675 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1132496000676 ribonuclease T; Provisional; Region: PRK05168 1132496000677 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1132496000678 active site 1132496000679 catalytic site [active] 1132496000680 substrate binding site [chemical binding]; other site 1132496000681 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1132496000682 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1132496000683 dimer interface [polypeptide binding]; other site 1132496000684 active site 1132496000685 metal binding site [ion binding]; metal-binding site 1132496000686 glutathione binding site [chemical binding]; other site 1132496000687 Predicted membrane protein [Function unknown]; Region: COG4984 1132496000688 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 1132496000689 Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929 1132496000690 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1132496000691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496000692 S-adenosylmethionine binding site [chemical binding]; other site 1132496000693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1132496000694 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1132496000695 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1132496000696 dimer interface [polypeptide binding]; other site 1132496000697 anticodon binding site; other site 1132496000698 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1132496000699 homodimer interface [polypeptide binding]; other site 1132496000700 motif 1; other site 1132496000701 active site 1132496000702 motif 2; other site 1132496000703 GAD domain; Region: GAD; pfam02938 1132496000704 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1132496000705 active site 1132496000706 motif 3; other site 1132496000707 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1132496000708 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1132496000709 nudix motif; other site 1132496000710 hypothetical protein; Validated; Region: PRK00110 1132496000711 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1132496000712 active site 1132496000713 putative DNA-binding cleft [nucleotide binding]; other site 1132496000714 dimer interface [polypeptide binding]; other site 1132496000715 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1132496000716 RuvA N terminal domain; Region: RuvA_N; pfam01330 1132496000717 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1132496000718 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1132496000719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1132496000720 Walker A motif; other site 1132496000721 ATP binding site [chemical binding]; other site 1132496000722 Walker B motif; other site 1132496000723 arginine finger; other site 1132496000724 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1132496000725 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1132496000726 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1132496000727 cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203 1132496000728 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1132496000729 Predicted membrane protein [Function unknown]; Region: COG3790 1132496000730 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1132496000731 active site 1132496000732 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1132496000733 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1132496000734 colicin uptake protein TolR; Provisional; Region: PRK11024 1132496000735 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1132496000736 TolA C-terminal; Region: TolA; pfam06519 1132496000737 translocation protein TolB; Provisional; Region: tolB; PRK01742 1132496000738 TolB amino-terminal domain; Region: TolB_N; pfam04052 1132496000739 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1132496000740 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1132496000741 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1132496000742 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1132496000743 ligand binding site [chemical binding]; other site 1132496000744 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 1132496000745 Protein of unknown function (DUF2572); Region: DUF2572; pfam10833 1132496000746 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1132496000747 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1132496000748 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1132496000749 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1132496000750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1132496000751 Coenzyme A binding pocket [chemical binding]; other site 1132496000752 DNA polymerase III, psi subunit [DNA replication, recombination, and repair]; Region: HolD; COG3050 1132496000753 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1132496000754 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1132496000755 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496000756 S-adenosylmethionine binding site [chemical binding]; other site 1132496000757 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 1132496000758 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1132496000759 Walker A/P-loop; other site 1132496000760 ATP binding site [chemical binding]; other site 1132496000761 Q-loop/lid; other site 1132496000762 ABC transporter signature motif; other site 1132496000763 Walker B; other site 1132496000764 D-loop; other site 1132496000765 H-loop/switch region; other site 1132496000766 TOBE domain; Region: TOBE_2; pfam08402 1132496000767 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1132496000768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496000769 dimer interface [polypeptide binding]; other site 1132496000770 conserved gate region; other site 1132496000771 putative PBP binding loops; other site 1132496000772 ABC-ATPase subunit interface; other site 1132496000773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496000774 dimer interface [polypeptide binding]; other site 1132496000775 conserved gate region; other site 1132496000776 putative PBP binding loops; other site 1132496000777 ABC-ATPase subunit interface; other site 1132496000778 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1132496000779 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1132496000780 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1132496000781 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1132496000782 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1132496000783 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1132496000784 Sugar specificity; other site 1132496000785 Pyrimidine base specificity; other site 1132496000786 ATP-binding site [chemical binding]; other site 1132496000787 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1132496000788 trimer interface [polypeptide binding]; other site 1132496000789 active site 1132496000790 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1132496000791 putative arabinose transporter; Provisional; Region: PRK03545 1132496000792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1132496000793 putative substrate translocation pore; other site 1132496000794 putative transporter; Provisional; Region: PRK11660 1132496000795 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1132496000796 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1132496000797 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1132496000798 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1132496000799 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1132496000800 active site 1132496000801 intersubunit interface [polypeptide binding]; other site 1132496000802 catalytic residue [active] 1132496000803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1132496000804 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1132496000805 putative metal binding site [ion binding]; other site 1132496000806 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1132496000807 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1132496000808 active site 1132496000809 HIGH motif; other site 1132496000810 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1132496000811 KMSKS motif; other site 1132496000812 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1132496000813 tRNA binding surface [nucleotide binding]; other site 1132496000814 anticodon binding site; other site 1132496000815 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1132496000816 substrate binding site [chemical binding]; other site 1132496000817 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1132496000818 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1132496000819 substrate binding site [chemical binding]; other site 1132496000820 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1132496000821 active site 1132496000822 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1132496000823 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1132496000824 FeS/SAM binding site; other site 1132496000825 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1132496000826 ATP cone domain; Region: ATP-cone; pfam03477 1132496000827 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1132496000828 effector binding site; other site 1132496000829 active site 1132496000830 Zn binding site [ion binding]; other site 1132496000831 glycine loop; other site 1132496000832 Haem-binding domain; Region: Haem_bd; pfam14376 1132496000833 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1132496000834 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1132496000835 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1132496000836 GDP-binding site [chemical binding]; other site 1132496000837 ACT binding site; other site 1132496000838 IMP binding site; other site 1132496000839 aspartate kinase III; Validated; Region: PRK09084 1132496000840 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1132496000841 nucleotide binding site [chemical binding]; other site 1132496000842 substrate binding site [chemical binding]; other site 1132496000843 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 1132496000844 lysine allosteric regulatory site; other site 1132496000845 dimer interface [polypeptide binding]; other site 1132496000846 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1132496000847 dimer interface [polypeptide binding]; other site 1132496000848 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1132496000849 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1132496000850 putative catalytic cysteine [active] 1132496000851 Predicted membrane protein [Function unknown]; Region: COG2860 1132496000852 UPF0126 domain; Region: UPF0126; pfam03458 1132496000853 UPF0126 domain; Region: UPF0126; pfam03458 1132496000854 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1132496000855 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 1132496000856 hypothetical protein; Provisional; Region: PRK07338 1132496000857 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1132496000858 metal binding site [ion binding]; metal-binding site 1132496000859 dimer interface [polypeptide binding]; other site 1132496000860 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1132496000861 AMP binding site [chemical binding]; other site 1132496000862 metal binding site [ion binding]; metal-binding site 1132496000863 active site 1132496000864 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1132496000865 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1132496000866 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1132496000867 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1132496000868 MltA specific insert domain; Region: MltA; smart00925 1132496000869 3D domain; Region: 3D; pfam06725 1132496000870 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1132496000871 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1132496000872 putative ATP binding site [chemical binding]; other site 1132496000873 putative substrate interface [chemical binding]; other site 1132496000874 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1132496000875 intersubunit interface [polypeptide binding]; other site 1132496000876 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1132496000877 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1132496000878 metal binding site [ion binding]; metal-binding site 1132496000879 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1132496000880 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1132496000881 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1132496000882 acyl-activating enzyme (AAE) consensus motif; other site 1132496000883 putative AMP binding site [chemical binding]; other site 1132496000884 putative active site [active] 1132496000885 putative CoA binding site [chemical binding]; other site 1132496000886 Entericidin EcnA/B family; Region: Entericidin; cl02322 1132496000887 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1132496000888 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1132496000889 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1132496000890 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1132496000891 SelR domain; Region: SelR; pfam01641 1132496000892 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1132496000893 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1132496000894 catalytic site [active] 1132496000895 G-X2-G-X-G-K; other site 1132496000896 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1132496000897 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1132496000898 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1132496000899 Zn2+ binding site [ion binding]; other site 1132496000900 Mg2+ binding site [ion binding]; other site 1132496000901 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1132496000902 synthetase active site [active] 1132496000903 NTP binding site [chemical binding]; other site 1132496000904 metal binding site [ion binding]; metal-binding site 1132496000905 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1132496000906 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1132496000907 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1132496000908 Pathogenicity locus; Region: Cdd1; pfam11731 1132496000909 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1132496000910 generic binding surface II; other site 1132496000911 ssDNA binding site; other site 1132496000912 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1132496000913 ATP binding site [chemical binding]; other site 1132496000914 putative Mg++ binding site [ion binding]; other site 1132496000915 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1132496000916 nucleotide binding region [chemical binding]; other site 1132496000917 ATP-binding site [chemical binding]; other site 1132496000918 Chorismate lyase; Region: Chor_lyase; cl01230 1132496000919 glutamate racemase; Provisional; Region: PRK00865 1132496000920 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 1132496000921 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 1132496000922 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1132496000923 TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776 1132496000924 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1132496000925 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1132496000926 ligand-binding site [chemical binding]; other site 1132496000927 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1132496000928 16S/18S rRNA binding site [nucleotide binding]; other site 1132496000929 S13e-L30e interaction site [polypeptide binding]; other site 1132496000930 25S rRNA binding site [nucleotide binding]; other site 1132496000931 antiporter inner membrane protein; Provisional; Region: PRK11670 1132496000932 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1132496000933 Walker A motif; other site 1132496000934 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1132496000935 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1132496000936 active site 1132496000937 HIGH motif; other site 1132496000938 KMSKS motif; other site 1132496000939 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1132496000940 tRNA binding surface [nucleotide binding]; other site 1132496000941 anticodon binding site; other site 1132496000942 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1132496000943 dimer interface [polypeptide binding]; other site 1132496000944 putative tRNA-binding site [nucleotide binding]; other site 1132496000945 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1132496000946 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1132496000947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496000948 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1132496000949 putative RNA binding site [nucleotide binding]; other site 1132496000950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496000951 S-adenosylmethionine binding site [chemical binding]; other site 1132496000952 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829 1132496000953 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09676 1132496000954 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09677 1132496000955 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09674 1132496000956 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 1132496000957 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 1132496000958 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 1132496000959 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1132496000960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1132496000961 dimer interface [polypeptide binding]; other site 1132496000962 phosphorylation site [posttranslational modification] 1132496000963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1132496000964 ATP binding site [chemical binding]; other site 1132496000965 Mg2+ binding site [ion binding]; other site 1132496000966 G-X-G motif; other site 1132496000967 Response regulator receiver domain; Region: Response_reg; pfam00072 1132496000968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1132496000969 active site 1132496000970 phosphorylation site [posttranslational modification] 1132496000971 intermolecular recognition site; other site 1132496000972 dimerization interface [polypeptide binding]; other site 1132496000973 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1132496000974 putative binding surface; other site 1132496000975 active site 1132496000976 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1132496000977 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1132496000978 active site 1132496000979 dimerization interface [polypeptide binding]; other site 1132496000980 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1132496000981 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1132496000982 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 1132496000983 Rrf2 family protein; Region: rrf2_super; TIGR00738 1132496000984 cysteine desulfurase; Provisional; Region: PRK14012 1132496000985 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1132496000986 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1132496000987 catalytic residue [active] 1132496000988 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1132496000989 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1132496000990 trimerization site [polypeptide binding]; other site 1132496000991 active site 1132496000992 iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011 1132496000993 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1132496000994 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1132496000995 HSP70 interaction site [polypeptide binding]; other site 1132496000996 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1132496000997 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1132496000998 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1132496000999 nucleotide binding site [chemical binding]; other site 1132496001000 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1132496001001 SBD interface [polypeptide binding]; other site 1132496001002 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1132496001003 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1132496001004 catalytic loop [active] 1132496001005 iron binding site [ion binding]; other site 1132496001006 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1132496001007 Transglycosylase; Region: Transgly; cl17702 1132496001008 Trp operon repressor; Provisional; Region: PRK01381 1132496001009 lytic murein transglycosylase; Provisional; Region: PRK11619 1132496001010 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1132496001011 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1132496001012 catalytic residue [active] 1132496001013 YciI-like protein; Reviewed; Region: PRK11370 1132496001014 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1132496001015 intracellular septation protein A; Reviewed; Region: PRK00259 1132496001016 OmpW family; Region: OmpW; cl17427 1132496001017 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1132496001018 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1132496001019 Walker A/P-loop; other site 1132496001020 ATP binding site [chemical binding]; other site 1132496001021 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1132496001022 Q-loop/lid; other site 1132496001023 ABC transporter signature motif; other site 1132496001024 Walker B; other site 1132496001025 D-loop; other site 1132496001026 H-loop/switch region; other site 1132496001027 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1132496001028 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1132496001029 GrpE; Region: GrpE; pfam01025 1132496001030 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1132496001031 dimer interface [polypeptide binding]; other site 1132496001032 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1132496001033 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1132496001034 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1132496001035 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1132496001036 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1132496001037 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1132496001038 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1132496001039 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1132496001040 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1132496001041 dimer interface [polypeptide binding]; other site 1132496001042 active site 1132496001043 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1132496001044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496001045 S-adenosylmethionine binding site [chemical binding]; other site 1132496001046 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1132496001047 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1132496001048 Na binding site [ion binding]; other site 1132496001049 ribonuclease G; Provisional; Region: PRK11712 1132496001050 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1132496001051 homodimer interface [polypeptide binding]; other site 1132496001052 oligonucleotide binding site [chemical binding]; other site 1132496001053 protease TldD; Provisional; Region: tldD; PRK10735 1132496001054 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1132496001055 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1132496001056 inhibitor-cofactor binding pocket; inhibition site 1132496001057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1132496001058 catalytic residue [active] 1132496001059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 1132496001060 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1132496001061 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1132496001062 substrate binding pocket [chemical binding]; other site 1132496001063 chain length determination region; other site 1132496001064 substrate-Mg2+ binding site; other site 1132496001065 catalytic residues [active] 1132496001066 aspartate-rich region 1; other site 1132496001067 active site lid residues [active] 1132496001068 aspartate-rich region 2; other site 1132496001069 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1132496001070 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1132496001071 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1132496001072 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1132496001073 EamA-like transporter family; Region: EamA; pfam00892 1132496001074 EamA-like transporter family; Region: EamA; pfam00892 1132496001075 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1132496001076 EamA-like transporter family; Region: EamA; pfam00892 1132496001077 EamA-like transporter family; Region: EamA; pfam00892 1132496001078 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1132496001079 GTP1/OBG; Region: GTP1_OBG; pfam01018 1132496001080 Obg GTPase; Region: Obg; cd01898 1132496001081 G1 box; other site 1132496001082 GTP/Mg2+ binding site [chemical binding]; other site 1132496001083 Switch I region; other site 1132496001084 G2 box; other site 1132496001085 G3 box; other site 1132496001086 Switch II region; other site 1132496001087 G4 box; other site 1132496001088 G5 box; other site 1132496001089 ferric uptake regulator; Provisional; Region: fur; PRK09462 1132496001090 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1132496001091 metal binding site 2 [ion binding]; metal-binding site 1132496001092 putative DNA binding helix; other site 1132496001093 metal binding site 1 [ion binding]; metal-binding site 1132496001094 dimer interface [polypeptide binding]; other site 1132496001095 structural Zn2+ binding site [ion binding]; other site 1132496001096 flavodoxin FldA; Validated; Region: PRK09267 1132496001097 LexA regulated protein; Provisional; Region: PRK11675 1132496001098 acyl-CoA esterase; Provisional; Region: PRK10673 1132496001099 PGAP1-like protein; Region: PGAP1; pfam07819 1132496001100 replication initiation regulator SeqA; Provisional; Region: PRK11187 1132496001101 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1132496001102 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1132496001103 acyl-activating enzyme (AAE) consensus motif; other site 1132496001104 putative AMP binding site [chemical binding]; other site 1132496001105 putative active site [active] 1132496001106 putative CoA binding site [chemical binding]; other site 1132496001107 hypothetical protein; Provisional; Region: PRK11281 1132496001108 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1132496001109 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1132496001110 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1132496001111 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1132496001112 Tetramer interface [polypeptide binding]; other site 1132496001113 active site 1132496001114 FMN-binding site [chemical binding]; other site 1132496001115 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1132496001116 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1132496001117 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1132496001118 hypothetical protein; Provisional; Region: PRK10621 1132496001119 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1132496001120 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1132496001121 putative acyl-acceptor binding pocket; other site 1132496001122 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1132496001123 active site 1132496001124 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1132496001125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1132496001126 Walker A motif; other site 1132496001127 ATP binding site [chemical binding]; other site 1132496001128 Walker B motif; other site 1132496001129 arginine finger; other site 1132496001130 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1132496001131 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1132496001132 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1132496001133 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1132496001134 homotrimer interaction site [polypeptide binding]; other site 1132496001135 putative active site [active] 1132496001136 YwiC-like protein; Region: YwiC; pfam14256 1132496001137 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1132496001138 Sel1-like repeats; Region: SEL1; smart00671 1132496001139 Sel1 repeat; Region: Sel1; cl02723 1132496001140 Sel1-like repeats; Region: SEL1; smart00671 1132496001141 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1132496001142 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1132496001143 CAP-like domain; other site 1132496001144 active site 1132496001145 primary dimer interface [polypeptide binding]; other site 1132496001146 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1132496001147 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1132496001148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1132496001149 ATP binding site [chemical binding]; other site 1132496001150 Mg2+ binding site [ion binding]; other site 1132496001151 G-X-G motif; other site 1132496001152 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1132496001153 anchoring element; other site 1132496001154 dimer interface [polypeptide binding]; other site 1132496001155 ATP binding site [chemical binding]; other site 1132496001156 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 1132496001157 active site 1132496001158 putative metal-binding site [ion binding]; other site 1132496001159 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1132496001160 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 1132496001161 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 1132496001162 dimer interface [polypeptide binding]; other site 1132496001163 active site 1132496001164 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1132496001165 catalytic residues [active] 1132496001166 substrate binding site [chemical binding]; other site 1132496001167 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1132496001168 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1132496001169 NAD(P) binding pocket [chemical binding]; other site 1132496001170 BtpA family; Region: BtpA; cl00440 1132496001171 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 1132496001172 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1132496001173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496001174 S-adenosylmethionine binding site [chemical binding]; other site 1132496001175 Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797 1132496001176 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1132496001177 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1132496001178 metal binding triad; other site 1132496001179 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1132496001180 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1132496001181 metal binding triad; other site 1132496001182 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1132496001183 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1132496001184 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1132496001185 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1132496001186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496001187 dimer interface [polypeptide binding]; other site 1132496001188 conserved gate region; other site 1132496001189 putative PBP binding loops; other site 1132496001190 ABC-ATPase subunit interface; other site 1132496001191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496001192 dimer interface [polypeptide binding]; other site 1132496001193 conserved gate region; other site 1132496001194 putative PBP binding loops; other site 1132496001195 ABC-ATPase subunit interface; other site 1132496001196 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 1132496001197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496001198 Walker A/P-loop; other site 1132496001199 ATP binding site [chemical binding]; other site 1132496001200 Q-loop/lid; other site 1132496001201 ABC transporter signature motif; other site 1132496001202 Walker B; other site 1132496001203 D-loop; other site 1132496001204 H-loop/switch region; other site 1132496001205 biotin synthase; Region: bioB; TIGR00433 1132496001206 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1132496001207 FeS/SAM binding site; other site 1132496001208 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1132496001209 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1132496001210 Na2 binding site [ion binding]; other site 1132496001211 putative substrate binding site 1 [chemical binding]; other site 1132496001212 Na binding site 1 [ion binding]; other site 1132496001213 putative substrate binding site 2 [chemical binding]; other site 1132496001214 endonuclease III; Provisional; Region: PRK10702 1132496001215 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1132496001216 minor groove reading motif; other site 1132496001217 helix-hairpin-helix signature motif; other site 1132496001218 substrate binding pocket [chemical binding]; other site 1132496001219 active site 1132496001220 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1132496001221 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1132496001222 electron transport complex protein RnfG; Validated; Region: PRK01908 1132496001223 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1132496001224 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 1132496001225 SLBB domain; Region: SLBB; pfam10531 1132496001226 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1132496001227 electron transport complex protein RnfB; Provisional; Region: PRK05113 1132496001228 Putative Fe-S cluster; Region: FeS; pfam04060 1132496001229 4Fe-4S binding domain; Region: Fer4; pfam00037 1132496001230 4Fe-4S binding domain; Region: Fer4; cl02805 1132496001231 electron transport complex protein RsxA; Provisional; Region: PRK05151 1132496001232 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1132496001233 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1132496001234 trimer interface [polypeptide binding]; other site 1132496001235 eyelet of channel; other site 1132496001236 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1132496001237 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1132496001238 trimer interface [polypeptide binding]; other site 1132496001239 eyelet of channel; other site 1132496001240 HemK family putative methylases; Region: hemK_fam; TIGR00536 1132496001241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496001242 S-adenosylmethionine binding site [chemical binding]; other site 1132496001243 hypothetical protein; Provisional; Region: PRK04946 1132496001244 Smr domain; Region: Smr; pfam01713 1132496001245 TIGR01666 family membrane protein; Region: YCCS 1132496001246 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1132496001247 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1132496001248 Predicted membrane protein [Function unknown]; Region: COG3304 1132496001249 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1132496001250 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1132496001251 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1132496001252 active site 1132496001253 dimer interfaces [polypeptide binding]; other site 1132496001254 catalytic residues [active] 1132496001255 hypothetical protein; Provisional; Region: PRK01904 1132496001256 acylphosphatase; Provisional; Region: PRK14448 1132496001257 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1132496001258 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1132496001259 ABC-ATPase subunit interface; other site 1132496001260 dimer interface [polypeptide binding]; other site 1132496001261 putative PBP binding regions; other site 1132496001262 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1132496001263 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1132496001264 ABC-ATPase subunit interface; other site 1132496001265 dimer interface [polypeptide binding]; other site 1132496001266 putative PBP binding regions; other site 1132496001267 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 1132496001268 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1132496001269 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1132496001270 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1132496001271 metal binding site [ion binding]; metal-binding site 1132496001272 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1132496001273 DsrC like protein; Region: DsrC; pfam04358 1132496001274 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1132496001275 YccA-like proteins; Region: YccA_like; cd10433 1132496001276 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1132496001277 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1132496001278 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1132496001279 dimerization interface [polypeptide binding]; other site 1132496001280 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 1132496001281 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1132496001282 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1132496001283 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1132496001284 Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864 1132496001285 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1132496001286 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1132496001287 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1132496001288 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1132496001289 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1132496001290 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1132496001291 molybdopterin cofactor binding site; other site 1132496001292 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1132496001293 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1132496001294 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1132496001295 Part of AAA domain; Region: AAA_19; pfam13245 1132496001296 Family description; Region: UvrD_C_2; pfam13538 1132496001297 replicative DNA helicase; Validated; Region: PRK06904 1132496001298 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1132496001299 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1132496001300 Walker A motif; other site 1132496001301 ATP binding site [chemical binding]; other site 1132496001302 Walker B motif; other site 1132496001303 DNA binding loops [nucleotide binding] 1132496001304 alanine racemase; Reviewed; Region: alr; PRK00053 1132496001305 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1132496001306 active site 1132496001307 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1132496001308 substrate binding site [chemical binding]; other site 1132496001309 catalytic residues [active] 1132496001310 dimer interface [polypeptide binding]; other site 1132496001311 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1132496001312 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1132496001313 active site 1132496001314 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1132496001315 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1132496001316 active site 1132496001317 dimer interface [polypeptide binding]; other site 1132496001318 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1132496001319 dimer interface [polypeptide binding]; other site 1132496001320 active site 1132496001321 Predicted transcriptional regulator [Transcription]; Region: COG2932 1132496001322 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 1132496001323 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1132496001324 Catalytic site [active] 1132496001325 Predicted transcriptional regulator [Transcription]; Region: Nlp; COG3423 1132496001326 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1132496001327 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1132496001328 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1132496001329 THF binding site; other site 1132496001330 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1132496001331 substrate binding site [chemical binding]; other site 1132496001332 THF binding site; other site 1132496001333 zinc-binding site [ion binding]; other site 1132496001334 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1132496001335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1132496001336 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1132496001337 putative dimerization interface [polypeptide binding]; other site 1132496001338 AzlC protein; Region: AzlC; cl00570 1132496001339 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 1132496001340 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1132496001341 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1132496001342 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1132496001343 ABC transporter; Region: ABC_tran_2; pfam12848 1132496001344 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1132496001345 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 1132496001346 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1132496001347 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1132496001348 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1132496001349 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1132496001350 excinuclease ABC subunit B; Provisional; Region: PRK05298 1132496001351 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 1132496001352 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1132496001353 ATP-binding site [chemical binding]; other site 1132496001354 ATP binding site [chemical binding]; other site 1132496001355 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1132496001356 nucleotide binding region [chemical binding]; other site 1132496001357 ATP-binding site [chemical binding]; other site 1132496001358 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1132496001359 UvrB/uvrC motif; Region: UVR; pfam02151 1132496001360 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1132496001361 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1132496001362 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1132496001363 putative active site [active] 1132496001364 heme pocket [chemical binding]; other site 1132496001365 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1132496001366 dimer interface [polypeptide binding]; other site 1132496001367 phosphorylation site [posttranslational modification] 1132496001368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1132496001369 ATP binding site [chemical binding]; other site 1132496001370 Mg2+ binding site [ion binding]; other site 1132496001371 G-X-G motif; other site 1132496001372 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1132496001373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1132496001374 active site 1132496001375 phosphorylation site [posttranslational modification] 1132496001376 intermolecular recognition site; other site 1132496001377 dimerization interface [polypeptide binding]; other site 1132496001378 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1132496001379 DNA binding site [nucleotide binding] 1132496001380 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1132496001381 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1132496001382 Walker A/P-loop; other site 1132496001383 ATP binding site [chemical binding]; other site 1132496001384 Q-loop/lid; other site 1132496001385 ABC transporter signature motif; other site 1132496001386 Walker B; other site 1132496001387 D-loop; other site 1132496001388 H-loop/switch region; other site 1132496001389 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1132496001390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496001391 dimer interface [polypeptide binding]; other site 1132496001392 conserved gate region; other site 1132496001393 putative PBP binding loops; other site 1132496001394 ABC-ATPase subunit interface; other site 1132496001395 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1132496001396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496001397 dimer interface [polypeptide binding]; other site 1132496001398 conserved gate region; other site 1132496001399 putative PBP binding loops; other site 1132496001400 ABC-ATPase subunit interface; other site 1132496001401 PBP superfamily domain; Region: PBP_like_2; cl17296 1132496001402 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1132496001403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496001404 S-adenosylmethionine binding site [chemical binding]; other site 1132496001405 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1132496001406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1132496001407 Walker A motif; other site 1132496001408 ATP binding site [chemical binding]; other site 1132496001409 Walker B motif; other site 1132496001410 arginine finger; other site 1132496001411 Peptidase family M41; Region: Peptidase_M41; pfam01434 1132496001412 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1132496001413 dihydropteroate synthase; Region: DHPS; TIGR01496 1132496001414 substrate binding pocket [chemical binding]; other site 1132496001415 dimer interface [polypeptide binding]; other site 1132496001416 inhibitor binding site; inhibition site 1132496001417 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1132496001418 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1132496001419 active site 1132496001420 substrate binding site [chemical binding]; other site 1132496001421 metal binding site [ion binding]; metal-binding site 1132496001422 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1132496001423 catalytic core [active] 1132496001424 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1132496001425 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 1132496001426 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1132496001427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 1132496001428 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 1132496001429 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1132496001430 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1132496001431 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1132496001432 catalytic residues [active] 1132496001433 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1132496001434 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1132496001435 Walker A/P-loop; other site 1132496001436 ATP binding site [chemical binding]; other site 1132496001437 Q-loop/lid; other site 1132496001438 ABC transporter signature motif; other site 1132496001439 Walker B; other site 1132496001440 D-loop; other site 1132496001441 H-loop/switch region; other site 1132496001442 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1132496001443 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1132496001444 FtsX-like permease family; Region: FtsX; pfam02687 1132496001445 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1132496001446 FtsX-like permease family; Region: FtsX; pfam02687 1132496001447 Predicted membrane protein [Function unknown]; Region: COG4393 1132496001448 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 1132496001449 Uncharacterized conserved protein [Function unknown]; Region: COG3350 1132496001450 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 1132496001451 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1132496001452 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1132496001453 active site pocket [active] 1132496001454 oxyanion hole [active] 1132496001455 catalytic triad [active] 1132496001456 active site nucleophile [active] 1132496001457 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1132496001458 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 1132496001459 Transglycosylase; Region: Transgly; pfam00912 1132496001460 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1132496001461 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1132496001462 Uncharacterized protein family (UPF0231); Region: UPF0231; cl11474 1132496001463 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1132496001464 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1132496001465 active site 1132496001466 PII uridylyl-transferase; Provisional; Region: glnD; PRK01759 1132496001467 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1132496001468 metal binding triad; other site 1132496001469 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1132496001470 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1132496001471 Zn2+ binding site [ion binding]; other site 1132496001472 Mg2+ binding site [ion binding]; other site 1132496001473 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1132496001474 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1132496001475 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1132496001476 EamA-like transporter family; Region: EamA; pfam00892 1132496001477 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1132496001478 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1132496001479 inhibitor-cofactor binding pocket; inhibition site 1132496001480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1132496001481 catalytic residue [active] 1132496001482 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 1132496001483 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1132496001484 Mg++ binding site [ion binding]; other site 1132496001485 putative catalytic motif [active] 1132496001486 substrate binding site [chemical binding]; other site 1132496001487 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 1132496001488 Predicted membrane protein [Function unknown]; Region: COG2431 1132496001489 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1132496001490 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1132496001491 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1132496001492 putative active site [active] 1132496001493 putative metal-binding site [ion binding]; other site 1132496001494 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1132496001495 active site 1132496001496 DNA polymerase IV; Validated; Region: PRK02406 1132496001497 DNA binding site [nucleotide binding] 1132496001498 heat shock protein HtpX; Provisional; Region: PRK05457 1132496001499 Protein of unknown function, DUF462; Region: DUF462; cl01190 1132496001500 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1132496001501 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1132496001502 Walker A/P-loop; other site 1132496001503 ATP binding site [chemical binding]; other site 1132496001504 Q-loop/lid; other site 1132496001505 ABC transporter signature motif; other site 1132496001506 Walker B; other site 1132496001507 D-loop; other site 1132496001508 H-loop/switch region; other site 1132496001509 inner membrane transport permease; Provisional; Region: PRK15066 1132496001510 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1132496001511 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1132496001512 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1132496001513 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 1132496001514 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 1132496001515 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 1132496001516 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1132496001517 Ligand Binding Site [chemical binding]; other site 1132496001518 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1132496001519 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1132496001520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1132496001521 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1132496001522 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1132496001523 Zn-ribbon-containing, possibly nucleic-acid-binding protein [General function prediction only]; Region: COG5595 1132496001524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 1132496001525 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1132496001526 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1132496001527 probable active site [active] 1132496001528 Uncharacterized protein family (UPF0181); Region: UPF0181; pfam03701 1132496001529 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1132496001530 DNA-binding site [nucleotide binding]; DNA binding site 1132496001531 RNA-binding motif; other site 1132496001532 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1132496001533 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1132496001534 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1132496001535 active site 1 [active] 1132496001536 dimer interface [polypeptide binding]; other site 1132496001537 active site 2 [active] 1132496001538 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1132496001539 putative deacylase active site [active] 1132496001540 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06901 1132496001541 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1132496001542 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1132496001543 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1132496001544 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1132496001545 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1132496001546 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1132496001547 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1132496001548 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1132496001549 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1132496001550 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1132496001551 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1132496001552 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1132496001553 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1132496001554 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1132496001555 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1132496001556 protein-splicing catalytic site; other site 1132496001557 thioester formation/cholesterol transfer; other site 1132496001558 Pretoxin HINT domain; Region: PT-HINT; pfam07591 1132496001559 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 1132496001560 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1132496001561 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1132496001562 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1132496001563 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1132496001564 Protein of unknown function (DUF1436); Region: DUF1436; pfam07262 1132496001565 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1132496001566 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1132496001567 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1132496001568 putative active site [active] 1132496001569 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1132496001570 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1132496001571 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 1132496001572 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 1132496001573 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1132496001574 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1132496001575 active site 1132496001576 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1132496001577 GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; Region: GT2_AmsE_like; cd04195 1132496001578 lytic murein transglycosylase; Region: MltB_2; TIGR02283 1132496001579 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1132496001580 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1132496001581 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1132496001582 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 1132496001583 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1132496001584 Part of AAA domain; Region: AAA_19; pfam13245 1132496001585 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1132496001586 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1132496001587 AAA domain; Region: AAA_30; pfam13604 1132496001588 Family description; Region: UvrD_C_2; pfam13538 1132496001589 Glutaredoxin 2 [Posttranslational modification, protein turnover, chaperones]; Region: GrxB; COG2999 1132496001590 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 1132496001591 C-terminal domain interface [polypeptide binding]; other site 1132496001592 GSH binding site (G-site) [chemical binding]; other site 1132496001593 catalytic residues [active] 1132496001594 putative dimer interface [polypeptide binding]; other site 1132496001595 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1132496001596 N-terminal domain interface [polypeptide binding]; other site 1132496001597 Uncharacterized conserved protein [Function unknown]; Region: COG3422 1132496001598 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1132496001599 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1132496001600 23S rRNA interface [nucleotide binding]; other site 1132496001601 L3 interface [polypeptide binding]; other site 1132496001602 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1132496001603 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1132496001604 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1132496001605 C-terminal domain interface [polypeptide binding]; other site 1132496001606 putative GSH binding site (G-site) [chemical binding]; other site 1132496001607 dimer interface [polypeptide binding]; other site 1132496001608 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1132496001609 dimer interface [polypeptide binding]; other site 1132496001610 N-terminal domain interface [polypeptide binding]; other site 1132496001611 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 1132496001612 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1132496001613 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1132496001614 active site 1132496001615 motif I; other site 1132496001616 motif II; other site 1132496001617 KpsF/GutQ family protein; Region: kpsF; TIGR00393 1132496001618 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1132496001619 putative active site [active] 1132496001620 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1132496001621 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 1132496001622 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1132496001623 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1132496001624 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1132496001625 active site 1132496001626 HIGH motif; other site 1132496001627 nucleotide binding site [chemical binding]; other site 1132496001628 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1132496001629 KMSKS motif; other site 1132496001630 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1132496001631 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1132496001632 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1132496001633 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1132496001634 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1132496001635 Coenzyme A binding pocket [chemical binding]; other site 1132496001636 hypothetical protein; Provisional; Region: PRK06762 1132496001637 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1132496001638 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1132496001639 TPP-binding site; other site 1132496001640 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1132496001641 PYR/PP interface [polypeptide binding]; other site 1132496001642 dimer interface [polypeptide binding]; other site 1132496001643 TPP binding site [chemical binding]; other site 1132496001644 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1132496001645 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1132496001646 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1132496001647 substrate binding pocket [chemical binding]; other site 1132496001648 chain length determination region; other site 1132496001649 substrate-Mg2+ binding site; other site 1132496001650 catalytic residues [active] 1132496001651 aspartate-rich region 1; other site 1132496001652 active site lid residues [active] 1132496001653 aspartate-rich region 2; other site 1132496001654 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1132496001655 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1132496001656 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1132496001657 molybdopterin cofactor binding site [chemical binding]; other site 1132496001658 substrate binding site [chemical binding]; other site 1132496001659 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1132496001660 molybdopterin cofactor binding site; other site 1132496001661 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1132496001662 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 1132496001663 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1132496001664 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1132496001665 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1132496001666 Ligand Binding Site [chemical binding]; other site 1132496001667 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1132496001668 active site residue [active] 1132496001669 dsDNA-mimic protein; Reviewed; Region: PRK05094 1132496001670 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1132496001671 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1132496001672 Moco binding site; other site 1132496001673 metal coordination site [ion binding]; other site 1132496001674 Predicted membrane protein [Function unknown]; Region: COG2717 1132496001675 hypothetical protein; Provisional; Region: PRK05170 1132496001676 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1132496001677 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1132496001678 glycogen branching enzyme; Provisional; Region: PRK05402 1132496001679 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1132496001680 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1132496001681 active site 1132496001682 catalytic site [active] 1132496001683 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1132496001684 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 1132496001685 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1132496001686 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1132496001687 active site 1132496001688 catalytic site [active] 1132496001689 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1132496001690 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1132496001691 ligand binding site; other site 1132496001692 oligomer interface; other site 1132496001693 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1132496001694 N-terminal domain interface [polypeptide binding]; other site 1132496001695 sulfate 1 binding site; other site 1132496001696 glycogen synthase; Provisional; Region: glgA; PRK00654 1132496001697 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1132496001698 ADP-binding pocket [chemical binding]; other site 1132496001699 homodimer interface [polypeptide binding]; other site 1132496001700 glycogen phosphorylase; Provisional; Region: PRK14986 1132496001701 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1132496001702 homodimer interface [polypeptide binding]; other site 1132496001703 active site pocket [active] 1132496001704 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1132496001705 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1132496001706 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1132496001707 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1132496001708 DNA binding site [nucleotide binding] 1132496001709 domain linker motif; other site 1132496001710 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1132496001711 dimerization interface [polypeptide binding]; other site 1132496001712 ligand binding site [chemical binding]; other site 1132496001713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1132496001714 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1132496001715 NAD(P) binding site [chemical binding]; other site 1132496001716 active site 1132496001717 arginine repressor; Provisional; Region: PRK05066 1132496001718 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1132496001719 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1132496001720 malate dehydrogenase; Provisional; Region: PRK05086 1132496001721 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1132496001722 NAD binding site [chemical binding]; other site 1132496001723 dimerization interface [polypeptide binding]; other site 1132496001724 Substrate binding site [chemical binding]; other site 1132496001725 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1132496001726 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1132496001727 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1132496001728 active site 1132496001729 HIGH motif; other site 1132496001730 KMSK motif region; other site 1132496001731 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1132496001732 tRNA binding surface [nucleotide binding]; other site 1132496001733 anticodon binding site; other site 1132496001734 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1132496001735 putative metal binding site [ion binding]; other site 1132496001736 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1132496001737 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1132496001738 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1132496001739 RF-1 domain; Region: RF-1; pfam00472 1132496001740 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1132496001741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1132496001742 Uncharacterized conserved protein [Function unknown]; Region: COG2912 1132496001743 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1132496001744 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1132496001745 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1132496001746 glycerate dehydrogenase; Provisional; Region: PRK06932 1132496001747 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1132496001748 putative ligand binding site [chemical binding]; other site 1132496001749 putative NAD binding site [chemical binding]; other site 1132496001750 catalytic site [active] 1132496001751 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1132496001752 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1132496001753 FtsX-like permease family; Region: FtsX; pfam02687 1132496001754 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1132496001755 Walker A/P-loop; other site 1132496001756 ATP binding site [chemical binding]; other site 1132496001757 ABC transporter; Region: ABC_tran; pfam00005 1132496001758 Q-loop/lid; other site 1132496001759 ABC transporter signature motif; other site 1132496001760 Walker B; other site 1132496001761 D-loop; other site 1132496001762 H-loop/switch region; other site 1132496001763 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1132496001764 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1132496001765 FtsX-like permease family; Region: FtsX; pfam02687 1132496001766 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1132496001767 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1132496001768 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 1132496001769 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1132496001770 Na binding site [ion binding]; other site 1132496001771 putative substrate binding site [chemical binding]; other site 1132496001772 cytosine deaminase; Provisional; Region: PRK09230 1132496001773 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1132496001774 active site 1132496001775 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1132496001776 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1132496001777 homodimer interface [polypeptide binding]; other site 1132496001778 substrate-cofactor binding pocket; other site 1132496001779 catalytic residue [active] 1132496001780 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1132496001781 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1132496001782 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1132496001783 dimerization interface [polypeptide binding]; other site 1132496001784 substrate binding pocket [chemical binding]; other site 1132496001785 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1132496001786 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 1132496001787 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1132496001788 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1132496001789 dinuclear metal binding motif [ion binding]; other site 1132496001790 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1132496001791 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1132496001792 active site 1132496001793 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1132496001794 catalytic triad [active] 1132496001795 dimer interface [polypeptide binding]; other site 1132496001796 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1132496001797 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1132496001798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496001799 Walker A/P-loop; other site 1132496001800 ATP binding site [chemical binding]; other site 1132496001801 Q-loop/lid; other site 1132496001802 ABC transporter signature motif; other site 1132496001803 Walker B; other site 1132496001804 D-loop; other site 1132496001805 H-loop/switch region; other site 1132496001806 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1132496001807 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1132496001808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496001809 Walker A/P-loop; other site 1132496001810 ATP binding site [chemical binding]; other site 1132496001811 Q-loop/lid; other site 1132496001812 ABC transporter signature motif; other site 1132496001813 Walker B; other site 1132496001814 D-loop; other site 1132496001815 H-loop/switch region; other site 1132496001816 thioredoxin reductase; Provisional; Region: PRK10262 1132496001817 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1132496001818 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1132496001819 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1132496001820 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1132496001821 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1132496001822 active site clefts [active] 1132496001823 zinc binding site [ion binding]; other site 1132496001824 dimer interface [polypeptide binding]; other site 1132496001825 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1132496001826 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1132496001827 N-terminal plug; other site 1132496001828 ligand-binding site [chemical binding]; other site 1132496001829 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1132496001830 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1132496001831 substrate binding site [chemical binding]; other site 1132496001832 active site 1132496001833 catalytic residues [active] 1132496001834 heterodimer interface [polypeptide binding]; other site 1132496001835 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1132496001836 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1132496001837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1132496001838 catalytic residue [active] 1132496001839 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1132496001840 malonic semialdehyde reductase; Provisional; Region: PRK10538 1132496001841 putative NAD(P) binding site [chemical binding]; other site 1132496001842 homotetramer interface [polypeptide binding]; other site 1132496001843 homodimer interface [polypeptide binding]; other site 1132496001844 active site 1132496001845 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1132496001846 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1132496001847 active site 1132496001848 ribulose/triose binding site [chemical binding]; other site 1132496001849 phosphate binding site [ion binding]; other site 1132496001850 substrate (anthranilate) binding pocket [chemical binding]; other site 1132496001851 product (indole) binding pocket [chemical binding]; other site 1132496001852 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1132496001853 active site 1132496001854 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1132496001855 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1132496001856 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1132496001857 Membrane transport protein; Region: Mem_trans; cl09117 1132496001858 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1132496001859 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1132496001860 glutamine binding [chemical binding]; other site 1132496001861 catalytic triad [active] 1132496001862 anthranilate synthase component I; Provisional; Region: PRK13564 1132496001863 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1132496001864 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1132496001865 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1132496001866 putative inner membrane peptidase; Provisional; Region: PRK11778 1132496001867 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1132496001868 tandem repeat interface [polypeptide binding]; other site 1132496001869 oligomer interface [polypeptide binding]; other site 1132496001870 active site residues [active] 1132496001871 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1132496001872 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1132496001873 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1132496001874 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1132496001875 ligand binding site [chemical binding]; other site 1132496001876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3001 1132496001877 Phosphotransferase enzyme family; Region: APH; pfam01636 1132496001878 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1132496001879 Na binding site [ion binding]; other site 1132496001880 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 1132496001881 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1132496001882 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1132496001883 Glutamate binding site [chemical binding]; other site 1132496001884 NAD binding site [chemical binding]; other site 1132496001885 catalytic residues [active] 1132496001886 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1132496001887 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1132496001888 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1132496001889 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1132496001890 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1132496001891 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1132496001892 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1132496001893 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1132496001894 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1132496001895 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1132496001896 peptide binding site [polypeptide binding]; other site 1132496001897 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1132496001898 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1132496001899 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1132496001900 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1132496001901 active site 1132496001902 dimer interface [polypeptide binding]; other site 1132496001903 motif 1; other site 1132496001904 motif 2; other site 1132496001905 motif 3; other site 1132496001906 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1132496001907 anticodon binding site; other site 1132496001908 Predicted permeases [General function prediction only]; Region: COG0730 1132496001909 putative transporter; Provisional; Region: PRK10484 1132496001910 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 1132496001911 Na binding site [ion binding]; other site 1132496001912 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1132496001913 Sulfatase; Region: Sulfatase; cl17466 1132496001914 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1132496001915 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1132496001916 ligand binding site [chemical binding]; other site 1132496001917 flexible hinge region; other site 1132496001918 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1132496001919 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1132496001920 FeS/SAM binding site; other site 1132496001921 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1132496001922 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1132496001923 active site 1132496001924 phosphate binding residues; other site 1132496001925 catalytic residues [active] 1132496001926 translation initiation factor IF-3; Region: infC; TIGR00168 1132496001927 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1132496001928 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1132496001929 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1132496001930 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1132496001931 23S rRNA binding site [nucleotide binding]; other site 1132496001932 L21 binding site [polypeptide binding]; other site 1132496001933 L13 binding site [polypeptide binding]; other site 1132496001934 YadA-like C-terminal region; Region: YadA; pfam03895 1132496001935 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1132496001936 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1132496001937 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1132496001938 Ligand Binding Site [chemical binding]; other site 1132496001939 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukF; COG3006 1132496001940 condesin subunit E; Provisional; Region: PRK05256 1132496001941 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 1132496001942 P-loop containing region of AAA domain; Region: AAA_29; cl17516 1132496001943 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1132496001944 exonuclease I; Provisional; Region: sbcB; PRK11779 1132496001945 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1132496001946 active site 1132496001947 catalytic site [active] 1132496001948 substrate binding site [chemical binding]; other site 1132496001949 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1132496001950 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1132496001951 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1132496001952 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1132496001953 active site 1132496001954 interdomain interaction site; other site 1132496001955 putative metal-binding site [ion binding]; other site 1132496001956 nucleotide binding site [chemical binding]; other site 1132496001957 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1132496001958 domain I; other site 1132496001959 DNA binding groove [nucleotide binding] 1132496001960 phosphate binding site [ion binding]; other site 1132496001961 domain II; other site 1132496001962 domain III; other site 1132496001963 nucleotide binding site [chemical binding]; other site 1132496001964 catalytic site [active] 1132496001965 domain IV; other site 1132496001966 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1132496001967 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1132496001968 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1132496001969 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1132496001970 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1132496001971 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1132496001972 active site 1132496001973 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1132496001974 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1132496001975 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1132496001976 quinone interaction residues [chemical binding]; other site 1132496001977 active site 1132496001978 catalytic residues [active] 1132496001979 FMN binding site [chemical binding]; other site 1132496001980 substrate binding site [chemical binding]; other site 1132496001981 aminopeptidase N; Provisional; Region: pepN; PRK14015 1132496001982 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1132496001983 active site 1132496001984 Zn binding site [ion binding]; other site 1132496001985 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1132496001986 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 1132496001987 CUT domain; Region: CUT; pfam02376 1132496001988 ATP-grasp domain; Region: ATP-grasp; pfam02222 1132496001989 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1132496001990 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1132496001991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1132496001992 homodimer interface [polypeptide binding]; other site 1132496001993 catalytic residue [active] 1132496001994 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1132496001995 MoaE homodimer interface [polypeptide binding]; other site 1132496001996 MoaD interaction [polypeptide binding]; other site 1132496001997 active site residues [active] 1132496001998 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1132496001999 MoaE interaction surface [polypeptide binding]; other site 1132496002000 MoeB interaction surface [polypeptide binding]; other site 1132496002001 thiocarboxylated glycine; other site 1132496002002 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1132496002003 trimer interface [polypeptide binding]; other site 1132496002004 dimer interface [polypeptide binding]; other site 1132496002005 putative active site [active] 1132496002006 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1132496002007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1132496002008 FeS/SAM binding site; other site 1132496002009 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1132496002010 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1132496002011 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1132496002012 phosphate binding site [ion binding]; other site 1132496002013 putative substrate binding pocket [chemical binding]; other site 1132496002014 dimer interface [polypeptide binding]; other site 1132496002015 NlpC/P60 family; Region: NLPC_P60; pfam00877 1132496002016 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1132496002017 IHF dimer interface [polypeptide binding]; other site 1132496002018 IHF - DNA interface [nucleotide binding]; other site 1132496002019 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1132496002020 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1132496002021 putative tRNA-binding site [nucleotide binding]; other site 1132496002022 B3/4 domain; Region: B3_4; pfam03483 1132496002023 tRNA synthetase B5 domain; Region: B5; smart00874 1132496002024 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1132496002025 dimer interface [polypeptide binding]; other site 1132496002026 motif 1; other site 1132496002027 motif 3; other site 1132496002028 motif 2; other site 1132496002029 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 1132496002030 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1132496002031 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1132496002032 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1132496002033 dimer interface [polypeptide binding]; other site 1132496002034 motif 1; other site 1132496002035 active site 1132496002036 motif 2; other site 1132496002037 motif 3; other site 1132496002038 Uncharacterized conserved protein [Function unknown]; Region: COG4283 1132496002039 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1132496002040 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1132496002041 active site 1132496002042 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1132496002043 catalytic core [active] 1132496002044 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1132496002045 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1132496002046 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1132496002047 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1132496002048 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1132496002049 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1132496002050 dimerization interface 3.5A [polypeptide binding]; other site 1132496002051 active site 1132496002052 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1132496002053 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1132496002054 active site 1132496002055 nucleophile elbow; other site 1132496002056 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1132496002057 5S rRNA interface [nucleotide binding]; other site 1132496002058 CTC domain interface [polypeptide binding]; other site 1132496002059 L16 interface [polypeptide binding]; other site 1132496002060 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1132496002061 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1132496002062 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1132496002063 AAA domain; Region: AAA_26; pfam13500 1132496002064 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1132496002065 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1132496002066 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1132496002067 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1132496002068 putative dimer interface [polypeptide binding]; other site 1132496002069 putative anticodon binding site; other site 1132496002070 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1132496002071 homodimer interface [polypeptide binding]; other site 1132496002072 motif 1; other site 1132496002073 motif 2; other site 1132496002074 active site 1132496002075 motif 3; other site 1132496002076 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 1132496002077 Transglycosylase; Region: Transgly; pfam00912 1132496002078 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1132496002079 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1132496002080 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1132496002081 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1132496002082 putative SAM binding site [chemical binding]; other site 1132496002083 putative homodimer interface [polypeptide binding]; other site 1132496002084 LppC putative lipoprotein; Region: LppC; pfam04348 1132496002085 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1132496002086 putative ligand binding site [chemical binding]; other site 1132496002087 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1132496002088 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1132496002089 dimer interface [polypeptide binding]; other site 1132496002090 active site 1132496002091 outer membrane lipoprotein; Provisional; Region: PRK11023 1132496002092 BON domain; Region: BON; pfam04972 1132496002093 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1132496002094 Lumazine binding domain; Region: Lum_binding; pfam00677 1132496002095 Lumazine binding domain; Region: Lum_binding; pfam00677 1132496002096 multidrug efflux protein; Reviewed; Region: PRK01766 1132496002097 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1132496002098 cation binding site [ion binding]; other site 1132496002099 putative oxidoreductase; Provisional; Region: PRK11579 1132496002100 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1132496002101 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1132496002102 pyruvate kinase; Provisional; Region: PRK05826 1132496002103 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1132496002104 domain interfaces; other site 1132496002105 active site 1132496002106 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1132496002107 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1132496002108 RecX family; Region: RecX; cl00936 1132496002109 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 1132496002110 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1132496002111 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 1132496002112 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1132496002113 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1132496002114 non-specific DNA binding site [nucleotide binding]; other site 1132496002115 salt bridge; other site 1132496002116 sequence-specific DNA binding site [nucleotide binding]; other site 1132496002117 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1132496002118 non-specific DNA binding site [nucleotide binding]; other site 1132496002119 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1132496002120 salt bridge; other site 1132496002121 sequence-specific DNA binding site [nucleotide binding]; other site 1132496002122 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1132496002123 Catalytic site [active] 1132496002124 Protein of unknown function DUF262; Region: DUF262; pfam03235 1132496002125 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1132496002126 Prophage antirepressor [Transcription]; Region: COG3617 1132496002127 BRO family, N-terminal domain; Region: Bro-N; smart01040 1132496002128 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1132496002129 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1132496002130 DNA-binding site [nucleotide binding]; DNA binding site 1132496002131 RNA-binding motif; other site 1132496002132 tellurite resistance protein TehB; Provisional; Region: PRK12335 1132496002133 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1132496002134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496002135 S-adenosylmethionine binding site [chemical binding]; other site 1132496002136 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1132496002137 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1132496002138 trimer interface [polypeptide binding]; other site 1132496002139 active site 1132496002140 substrate binding site [chemical binding]; other site 1132496002141 CoA binding site [chemical binding]; other site 1132496002142 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1132496002143 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1132496002144 MG2 domain; Region: A2M_N; pfam01835 1132496002145 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1132496002146 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1132496002147 surface patch; other site 1132496002148 thioester region; other site 1132496002149 specificity defining residues; other site 1132496002150 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1132496002151 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1132496002152 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1132496002153 substrate binding site [chemical binding]; other site 1132496002154 dimerization interface [polypeptide binding]; other site 1132496002155 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1132496002156 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1132496002157 RNA binding surface [nucleotide binding]; other site 1132496002158 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1132496002159 probable active site [active] 1132496002160 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1132496002161 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 1132496002162 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1132496002163 catalytic site [active] 1132496002164 Asp-box motif; other site 1132496002165 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1132496002166 Chorismate mutase type II; Region: CM_2; cl00693 1132496002167 prephenate dehydrogenase; Validated; Region: PRK08507 1132496002168 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1132496002169 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1132496002170 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1132496002171 Ferritin-like domain; Region: Ferritin; pfam00210 1132496002172 ferroxidase diiron center [ion binding]; other site 1132496002173 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1132496002174 Ferritin-like domain; Region: Ferritin; pfam00210 1132496002175 ferroxidase diiron center [ion binding]; other site 1132496002176 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1132496002177 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1132496002178 ligand binding site [chemical binding]; other site 1132496002179 flexible hinge region; other site 1132496002180 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1132496002181 putative switch regulator; other site 1132496002182 non-specific DNA interactions [nucleotide binding]; other site 1132496002183 DNA binding site [nucleotide binding] 1132496002184 sequence specific DNA binding site [nucleotide binding]; other site 1132496002185 putative cAMP binding site [chemical binding]; other site 1132496002186 universal stress protein UspE; Provisional; Region: PRK11175 1132496002187 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1132496002188 Ligand Binding Site [chemical binding]; other site 1132496002189 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1132496002190 Ligand Binding Site [chemical binding]; other site 1132496002191 Soluble cytochrome b562 [Energy production and conversion]; Region: CybC; COG3783 1132496002192 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 1132496002193 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1132496002194 tandem repeat interface [polypeptide binding]; other site 1132496002195 oligomer interface [polypeptide binding]; other site 1132496002196 active site residues [active] 1132496002197 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1132496002198 tandem repeat interface [polypeptide binding]; other site 1132496002199 oligomer interface [polypeptide binding]; other site 1132496002200 active site residues [active] 1132496002201 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1132496002202 putative FMN binding site [chemical binding]; other site 1132496002203 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 1132496002204 ATP binding site [chemical binding]; other site 1132496002205 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1132496002206 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1132496002207 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1132496002208 active site 1132496002209 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1132496002210 dimerization interface [polypeptide binding]; other site 1132496002211 active site 1132496002212 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1132496002213 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1132496002214 peptide binding site [polypeptide binding]; other site 1132496002215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1132496002216 oligopeptidase A; Provisional; Region: PRK10911 1132496002217 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1132496002218 active site 1132496002219 Zn binding site [ion binding]; other site 1132496002220 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1132496002221 MarR family; Region: MarR_2; cl17246 1132496002222 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1132496002223 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1132496002224 nucleotide binding site [chemical binding]; other site 1132496002225 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1132496002226 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1132496002227 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1132496002228 tRNA; other site 1132496002229 putative tRNA binding site [nucleotide binding]; other site 1132496002230 putative NADP binding site [chemical binding]; other site 1132496002231 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1132496002232 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1132496002233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496002234 uncharacterized domain; Region: TIGR00702 1132496002235 YcaO-like family; Region: YcaO; pfam02624 1132496002236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1132496002237 Protein of unknown function (DUF1043); Region: DUF1043; pfam06295 1132496002238 TIGR01619 family protein; Region: hyp_HI0040 1132496002239 Family of unknown function (DUF695); Region: DUF695; pfam05117 1132496002240 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1132496002241 putative catalytic site [active] 1132496002242 putative phosphate binding site [ion binding]; other site 1132496002243 active site 1132496002244 metal binding site A [ion binding]; metal-binding site 1132496002245 DNA binding site [nucleotide binding] 1132496002246 putative AP binding site [nucleotide binding]; other site 1132496002247 putative metal binding site B [ion binding]; other site 1132496002248 acetyl-CoA synthetase; Provisional; Region: PRK00174 1132496002249 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1132496002250 active site 1132496002251 CoA binding site [chemical binding]; other site 1132496002252 acyl-activating enzyme (AAE) consensus motif; other site 1132496002253 AMP binding site [chemical binding]; other site 1132496002254 acetate binding site [chemical binding]; other site 1132496002255 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1132496002256 homodecamer interface [polypeptide binding]; other site 1132496002257 GTP cyclohydrolase I; Provisional; Region: PLN03044 1132496002258 active site 1132496002259 putative catalytic site residues [active] 1132496002260 zinc binding site [ion binding]; other site 1132496002261 GTP-CH-I/GFRP interaction surface; other site 1132496002262 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1132496002263 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1132496002264 dimer interface [polypeptide binding]; other site 1132496002265 putative functional site; other site 1132496002266 putative MPT binding site; other site 1132496002267 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1132496002268 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1132496002269 ATP binding site [chemical binding]; other site 1132496002270 substrate interface [chemical binding]; other site 1132496002271 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1132496002272 Flavoprotein; Region: Flavoprotein; pfam02441 1132496002273 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1132496002274 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1132496002275 active site 1132496002276 tetramer interface [polypeptide binding]; other site 1132496002277 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1132496002278 active site 1132496002279 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1132496002280 Colicin V production protein; Region: Colicin_V; cl00567 1132496002281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3092 1132496002282 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1132496002283 propionate/acetate kinase; Provisional; Region: PRK12379 1132496002284 phosphate acetyltransferase; Reviewed; Region: PRK05632 1132496002285 DRTGG domain; Region: DRTGG; pfam07085 1132496002286 phosphate acetyltransferase; Region: pta; TIGR00651 1132496002287 ribonuclease D; Provisional; Region: PRK10829 1132496002288 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1132496002289 catalytic site [active] 1132496002290 putative active site [active] 1132496002291 putative substrate binding site [chemical binding]; other site 1132496002292 HRDC domain; Region: HRDC; pfam00570 1132496002293 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1132496002294 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1132496002295 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1132496002296 acyl-activating enzyme (AAE) consensus motif; other site 1132496002297 putative AMP binding site [chemical binding]; other site 1132496002298 putative active site [active] 1132496002299 putative CoA binding site [chemical binding]; other site 1132496002300 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 1132496002301 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1132496002302 Glycoprotease family; Region: Peptidase_M22; pfam00814 1132496002303 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1132496002304 DEAD_2; Region: DEAD_2; pfam06733 1132496002305 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1132496002306 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1132496002307 active site 1132496002308 phosphate binding residues; other site 1132496002309 catalytic residues [active] 1132496002310 Predicted permeases [General function prediction only]; Region: COG0679 1132496002311 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1132496002312 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1132496002313 trimer interface [polypeptide binding]; other site 1132496002314 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 1132496002315 YadA-like C-terminal region; Region: YadA; pfam03895 1132496002316 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1132496002317 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1132496002318 trimer interface [polypeptide binding]; other site 1132496002319 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1132496002320 trimer interface [polypeptide binding]; other site 1132496002321 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1132496002322 trimer interface [polypeptide binding]; other site 1132496002323 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1132496002324 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1132496002325 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1132496002326 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1132496002327 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1132496002328 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1132496002329 ATP cone domain; Region: ATP-cone; pfam03477 1132496002330 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1132496002331 active site 1132496002332 dimer interface [polypeptide binding]; other site 1132496002333 catalytic residues [active] 1132496002334 effector binding site; other site 1132496002335 R2 peptide binding site; other site 1132496002336 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1132496002337 Na2 binding site [ion binding]; other site 1132496002338 putative substrate binding site 1 [chemical binding]; other site 1132496002339 Na binding site 1 [ion binding]; other site 1132496002340 putative substrate binding site 2 [chemical binding]; other site 1132496002341 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1132496002342 dimer interface [polypeptide binding]; other site 1132496002343 putative radical transfer pathway; other site 1132496002344 diiron center [ion binding]; other site 1132496002345 tyrosyl radical; other site 1132496002346 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1132496002347 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1132496002348 catalytic loop [active] 1132496002349 iron binding site [ion binding]; other site 1132496002350 tetrathionate reductase subunit A; Provisional; Region: PRK14991 1132496002351 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1132496002352 molybdopterin cofactor binding site; other site 1132496002353 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 1132496002354 putative molybdopterin cofactor binding site [chemical binding]; other site 1132496002355 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 1132496002356 putative molybdopterin cofactor binding site; other site 1132496002357 tetrathionate reductase subunit C; Provisional; Region: PRK14992 1132496002358 tetrathionate reductase subunit B; Provisional; Region: PRK14993 1132496002359 4Fe-4S binding domain; Region: Fer4; pfam00037 1132496002360 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1132496002361 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1132496002362 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1132496002363 dimer interface [polypeptide binding]; other site 1132496002364 phosphorylation site [posttranslational modification] 1132496002365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1132496002366 ATP binding site [chemical binding]; other site 1132496002367 Mg2+ binding site [ion binding]; other site 1132496002368 G-X-G motif; other site 1132496002369 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1132496002370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1132496002371 active site 1132496002372 phosphorylation site [posttranslational modification] 1132496002373 intermolecular recognition site; other site 1132496002374 dimerization interface [polypeptide binding]; other site 1132496002375 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1132496002376 DNA binding residues [nucleotide binding] 1132496002377 dimerization interface [polypeptide binding]; other site 1132496002378 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1132496002379 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1132496002380 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1132496002381 LysE type translocator; Region: LysE; cl00565 1132496002382 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1132496002383 tetramer interfaces [polypeptide binding]; other site 1132496002384 binuclear metal-binding site [ion binding]; other site 1132496002385 Thiamine monophosphate kinase [Coenzyme metabolism]; Region: ThiL; COG0611 1132496002386 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1132496002387 ATP binding site [chemical binding]; other site 1132496002388 dimerization interface [polypeptide binding]; other site 1132496002389 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1132496002390 putative RNA binding site [nucleotide binding]; other site 1132496002391 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1132496002392 homopentamer interface [polypeptide binding]; other site 1132496002393 active site 1132496002394 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1132496002395 aromatic amino acid transport protein; Region: araaP; TIGR00837 1132496002396 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1132496002397 dimer interface [polypeptide binding]; other site 1132496002398 FMN binding site [chemical binding]; other site 1132496002399 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1132496002400 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1132496002401 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1132496002402 protein binding site [polypeptide binding]; other site 1132496002403 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1132496002404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1132496002405 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1132496002406 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1132496002407 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1132496002408 nucleotide binding site [chemical binding]; other site 1132496002409 photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042 1132496002410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1132496002411 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 1132496002412 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1132496002413 homodimer interface [polypeptide binding]; other site 1132496002414 substrate-cofactor binding pocket; other site 1132496002415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1132496002416 catalytic residue [active] 1132496002417 chaperone protein DnaJ; Provisional; Region: PRK10767 1132496002418 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1132496002419 HSP70 interaction site [polypeptide binding]; other site 1132496002420 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1132496002421 substrate binding site [polypeptide binding]; other site 1132496002422 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1132496002423 Zn binding sites [ion binding]; other site 1132496002424 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1132496002425 dimer interface [polypeptide binding]; other site 1132496002426 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1132496002427 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1132496002428 N-terminal plug; other site 1132496002429 ligand-binding site [chemical binding]; other site 1132496002430 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1132496002431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496002432 Walker A/P-loop; other site 1132496002433 ATP binding site [chemical binding]; other site 1132496002434 Q-loop/lid; other site 1132496002435 ABC transporter signature motif; other site 1132496002436 Walker B; other site 1132496002437 D-loop; other site 1132496002438 H-loop/switch region; other site 1132496002439 TOBE domain; Region: TOBE; pfam03459 1132496002440 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1132496002441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496002442 dimer interface [polypeptide binding]; other site 1132496002443 conserved gate region; other site 1132496002444 putative PBP binding loops; other site 1132496002445 ABC-ATPase subunit interface; other site 1132496002446 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1132496002447 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1132496002448 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1132496002449 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1132496002450 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1132496002451 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 1132496002452 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1132496002453 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1132496002454 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1132496002455 TOBE domain; Region: TOBE; pfam03459 1132496002456 5'-nucleotidase; Provisional; Region: PRK03826 1132496002457 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1132496002458 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1132496002459 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1132496002460 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1132496002461 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1132496002462 catalytic motif [active] 1132496002463 Zn binding site [ion binding]; other site 1132496002464 RibD C-terminal domain; Region: RibD_C; cl17279 1132496002465 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1132496002466 ATP cone domain; Region: ATP-cone; pfam03477 1132496002467 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 1132496002468 putative active site [active] 1132496002469 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1132496002470 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1132496002471 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1132496002472 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1132496002473 ligand binding site [chemical binding]; other site 1132496002474 homodimer interface [polypeptide binding]; other site 1132496002475 NAD(P) binding site [chemical binding]; other site 1132496002476 trimer interface B [polypeptide binding]; other site 1132496002477 trimer interface A [polypeptide binding]; other site 1132496002478 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1132496002479 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1132496002480 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1132496002481 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1132496002482 active site 1132496002483 HIGH motif; other site 1132496002484 dimer interface [polypeptide binding]; other site 1132496002485 KMSKS motif; other site 1132496002486 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1132496002487 RNA binding surface [nucleotide binding]; other site 1132496002488 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1132496002489 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1132496002490 RNA binding site [nucleotide binding]; other site 1132496002491 active site 1132496002492 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1132496002493 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1132496002494 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1132496002495 translation initiation factor IF-2; Region: IF-2; TIGR00487 1132496002496 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1132496002497 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1132496002498 G1 box; other site 1132496002499 putative GEF interaction site [polypeptide binding]; other site 1132496002500 GTP/Mg2+ binding site [chemical binding]; other site 1132496002501 Switch I region; other site 1132496002502 G2 box; other site 1132496002503 G3 box; other site 1132496002504 Switch II region; other site 1132496002505 G4 box; other site 1132496002506 G5 box; other site 1132496002507 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1132496002508 Translation-initiation factor 2; Region: IF-2; pfam11987 1132496002509 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1132496002510 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1132496002511 NusA N-terminal domain; Region: NusA_N; pfam08529 1132496002512 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1132496002513 RNA binding site [nucleotide binding]; other site 1132496002514 homodimer interface [polypeptide binding]; other site 1132496002515 NusA-like KH domain; Region: KH_5; pfam13184 1132496002516 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1132496002517 G-X-X-G motif; other site 1132496002518 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1132496002519 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1132496002520 Sm and related proteins; Region: Sm_like; cl00259 1132496002521 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 1132496002522 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1132496002523 putative oligomer interface [polypeptide binding]; other site 1132496002524 putative RNA binding site [nucleotide binding]; other site 1132496002525 transcriptional repressor UlaR; Provisional; Region: PRK13509 1132496002526 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1132496002527 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1132496002528 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1132496002529 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1132496002530 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 1132496002531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 1132496002532 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1132496002533 active site 1132496002534 P-loop; other site 1132496002535 phosphorylation site [posttranslational modification] 1132496002536 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1132496002537 active site 1132496002538 phosphorylation site [posttranslational modification] 1132496002539 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1132496002540 active site 1132496002541 dimer interface [polypeptide binding]; other site 1132496002542 magnesium binding site [ion binding]; other site 1132496002543 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 1132496002544 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1132496002545 Transposase IS200 like; Region: Y1_Tnp; cl00848 1132496002546 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1132496002547 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 1132496002548 active site 1132496002549 catalytic triad [active] 1132496002550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1132496002551 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1132496002552 Walker A motif; other site 1132496002553 ATP binding site [chemical binding]; other site 1132496002554 Walker B motif; other site 1132496002555 arginine finger; other site 1132496002556 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1132496002557 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1132496002558 ATP binding site [chemical binding]; other site 1132496002559 putative Mg++ binding site [ion binding]; other site 1132496002560 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1132496002561 nucleotide binding region [chemical binding]; other site 1132496002562 ATP-binding site [chemical binding]; other site 1132496002563 Helicase associated domain (HA2); Region: HA2; pfam04408 1132496002564 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1132496002565 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1132496002566 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1132496002567 Predicted membrane protein [Function unknown]; Region: COG2707 1132496002568 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 1132496002569 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1132496002570 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 1132496002571 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1132496002572 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1132496002573 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1132496002574 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1132496002575 active site 1132496002576 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1132496002577 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1132496002578 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1132496002579 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1132496002580 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1132496002581 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1132496002582 active site 1132496002583 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1132496002584 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1132496002585 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 1132496002586 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1132496002587 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1132496002588 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1132496002589 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1132496002590 Walker A/P-loop; other site 1132496002591 ATP binding site [chemical binding]; other site 1132496002592 Q-loop/lid; other site 1132496002593 ABC transporter signature motif; other site 1132496002594 Walker B; other site 1132496002595 D-loop; other site 1132496002596 H-loop/switch region; other site 1132496002597 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1132496002598 putative GSH binding site [chemical binding]; other site 1132496002599 catalytic residues [active] 1132496002600 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1132496002601 Repair protein; Region: Repair_PSII; pfam04536 1132496002602 Predicted membrane protein [Function unknown]; Region: COG3762 1132496002603 LemA family; Region: LemA; pfam04011 1132496002604 outer membrane protein A; Reviewed; Region: PRK10808 1132496002605 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1132496002606 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1132496002607 ligand binding site [chemical binding]; other site 1132496002608 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1132496002609 FAD binding domain; Region: FAD_binding_4; pfam01565 1132496002610 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1132496002611 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1132496002612 CoenzymeA binding site [chemical binding]; other site 1132496002613 subunit interaction site [polypeptide binding]; other site 1132496002614 PHB binding site; other site 1132496002615 ferrochelatase; Reviewed; Region: hemH; PRK00035 1132496002616 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1132496002617 C-terminal domain interface [polypeptide binding]; other site 1132496002618 active site 1132496002619 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1132496002620 active site 1132496002621 N-terminal domain interface [polypeptide binding]; other site 1132496002622 selenophosphate synthetase; Provisional; Region: PRK00943 1132496002623 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1132496002624 dimerization interface [polypeptide binding]; other site 1132496002625 putative ATP binding site [chemical binding]; other site 1132496002626 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1132496002627 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1132496002628 DNA binding site [nucleotide binding] 1132496002629 domain linker motif; other site 1132496002630 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1132496002631 putative ligand binding site [chemical binding]; other site 1132496002632 putative dimerization interface [polypeptide binding]; other site 1132496002633 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1132496002634 Shikimate kinase; Region: SKI; pfam01202 1132496002635 ATP-binding site [chemical binding]; other site 1132496002636 Gluconate-6-phosphate binding site [chemical binding]; other site 1132496002637 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1132496002638 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1132496002639 cystathionine beta-lyase; Provisional; Region: PRK08114 1132496002640 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1132496002641 homodimer interface [polypeptide binding]; other site 1132496002642 substrate-cofactor binding pocket; other site 1132496002643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1132496002644 catalytic residue [active] 1132496002645 peroxidase; Provisional; Region: PRK15000 1132496002646 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1132496002647 dimer interface [polypeptide binding]; other site 1132496002648 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1132496002649 catalytic triad [active] 1132496002650 peroxidatic and resolving cysteines [active] 1132496002651 translation initiation factor Sui1; Validated; Region: PRK06824 1132496002652 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1132496002653 putative rRNA binding site [nucleotide binding]; other site 1132496002654 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1132496002655 active site 1132496002656 dimer interface [polypeptide binding]; other site 1132496002657 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 1132496002658 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 1132496002659 iron binding site [ion binding]; other site 1132496002660 Predicted membrane protein [Function unknown]; Region: COG3771 1132496002661 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1132496002662 IHF dimer interface [polypeptide binding]; other site 1132496002663 IHF - DNA interface [nucleotide binding]; other site 1132496002664 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1132496002665 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1132496002666 RNA binding site [nucleotide binding]; other site 1132496002667 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1132496002668 RNA binding site [nucleotide binding]; other site 1132496002669 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1132496002670 RNA binding site [nucleotide binding]; other site 1132496002671 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1132496002672 RNA binding site [nucleotide binding]; other site 1132496002673 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1132496002674 RNA binding site [nucleotide binding]; other site 1132496002675 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1132496002676 RNA binding site [nucleotide binding]; other site 1132496002677 cytidylate kinase; Provisional; Region: cmk; PRK00023 1132496002678 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1132496002679 CMP-binding site; other site 1132496002680 The sites determining sugar specificity; other site 1132496002681 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1132496002682 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1132496002683 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 1132496002684 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1132496002685 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1132496002686 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1132496002687 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1132496002688 ornithine decarboxylase; Provisional; Region: PRK13578 1132496002689 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1132496002690 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1132496002691 homodimer interface [polypeptide binding]; other site 1132496002692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1132496002693 catalytic residue [active] 1132496002694 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1132496002695 putrescine transporter; Provisional; Region: potE; PRK10655 1132496002696 ornithine carbamoyltransferase; Validated; Region: PRK02102 1132496002697 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1132496002698 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1132496002699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 1132496002700 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1132496002701 tyrosine phenol-lyase; Provisional; Region: PRK13237 1132496002702 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 1132496002703 substrate binding site [chemical binding]; other site 1132496002704 tetramer interface [polypeptide binding]; other site 1132496002705 catalytic residue [active] 1132496002706 argininosuccinate synthase; Validated; Region: PRK05370 1132496002707 argininosuccinate synthase; Provisional; Region: PRK13820 1132496002708 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1132496002709 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1132496002710 putative NAD(P) binding site [chemical binding]; other site 1132496002711 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1132496002712 ATP binding site [chemical binding]; other site 1132496002713 active site 1132496002714 substrate binding site [chemical binding]; other site 1132496002715 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1132496002716 Sulfatase; Region: Sulfatase; pfam00884 1132496002717 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1132496002718 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1132496002719 G1 box; other site 1132496002720 putative GEF interaction site [polypeptide binding]; other site 1132496002721 GTP/Mg2+ binding site [chemical binding]; other site 1132496002722 Switch I region; other site 1132496002723 G2 box; other site 1132496002724 G3 box; other site 1132496002725 Switch II region; other site 1132496002726 G4 box; other site 1132496002727 G5 box; other site 1132496002728 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1132496002729 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1132496002730 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1132496002731 dimerization interface [polypeptide binding]; other site 1132496002732 DPS ferroxidase diiron center [ion binding]; other site 1132496002733 ion pore; other site 1132496002734 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1132496002735 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1132496002736 HIGH motif; other site 1132496002737 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1132496002738 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1132496002739 active site 1132496002740 KMSKS motif; other site 1132496002741 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1132496002742 tRNA binding surface [nucleotide binding]; other site 1132496002743 anticodon binding site; other site 1132496002744 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1132496002745 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1132496002746 dimer interface [polypeptide binding]; other site 1132496002747 catalytic triad [active] 1132496002748 peroxidatic and resolving cysteines [active] 1132496002749 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 1132496002750 oligomer interface [polypeptide binding]; other site 1132496002751 DNA polymerase III subunit chi; Validated; Region: PRK05728 1132496002752 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1132496002753 Class II fumarases; Region: Fumarase_classII; cd01362 1132496002754 active site 1132496002755 tetramer interface [polypeptide binding]; other site 1132496002756 hypothetical protein; Provisional; Region: PRK04940 1132496002757 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1132496002758 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1132496002759 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1132496002760 GSH binding site [chemical binding]; other site 1132496002761 catalytic residues [active] 1132496002762 N-acetylglutamate synthase; Validated; Region: PRK05279 1132496002763 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1132496002764 putative feedback inhibition sensing region; other site 1132496002765 putative nucleotide binding site [chemical binding]; other site 1132496002766 putative substrate binding site [chemical binding]; other site 1132496002767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1132496002768 Coenzyme A binding pocket [chemical binding]; other site 1132496002769 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1132496002770 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1132496002771 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1132496002772 Protein of unknown function (DUF986); Region: DUF986; cl01983 1132496002773 potential frameshift: common BLAST hit: gi|15602696|ref|NP_245768.1| OmpH porin-like protein 1132496002774 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1132496002775 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1132496002776 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1132496002777 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1132496002778 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1132496002779 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1132496002780 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1132496002781 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1132496002782 active pocket/dimerization site; other site 1132496002783 active site 1132496002784 phosphorylation site [posttranslational modification] 1132496002785 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1132496002786 active site 1132496002787 phosphorylation site [posttranslational modification] 1132496002788 benzoate transport; Region: 2A0115; TIGR00895 1132496002789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1132496002790 putative substrate translocation pore; other site 1132496002791 hypothetical protein; Provisional; Region: PRK05423 1132496002792 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1132496002793 homodimer interface [polypeptide binding]; other site 1132496002794 substrate-cofactor binding pocket; other site 1132496002795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1132496002796 catalytic residue [active] 1132496002797 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1132496002798 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1132496002799 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1132496002800 homodimer interface [polypeptide binding]; other site 1132496002801 catalytic residue [active] 1132496002802 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1132496002803 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1132496002804 hinge; other site 1132496002805 active site 1132496002806 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1132496002807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496002808 S-adenosylmethionine binding site [chemical binding]; other site 1132496002809 DNA gyrase subunit A; Validated; Region: PRK05560 1132496002810 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1132496002811 CAP-like domain; other site 1132496002812 active site 1132496002813 primary dimer interface [polypeptide binding]; other site 1132496002814 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1132496002815 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1132496002816 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1132496002817 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1132496002818 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1132496002819 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1132496002820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3094 1132496002821 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1132496002822 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 1132496002823 TadE-like protein; Region: TadE; pfam07811 1132496002824 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1132496002825 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1132496002826 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1132496002827 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1132496002828 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1132496002829 ATP binding site [chemical binding]; other site 1132496002830 Walker A motif; other site 1132496002831 hexamer interface [polypeptide binding]; other site 1132496002832 Walker B motif; other site 1132496002833 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 1132496002834 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1132496002835 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1132496002836 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1132496002837 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1132496002838 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 1132496002839 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1132496002840 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1132496002841 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1132496002842 active site 1132496002843 catalytic site [active] 1132496002844 putative DNA binding site [nucleotide binding]; other site 1132496002845 GIY-YIG motif/motif A; other site 1132496002846 metal binding site [ion binding]; metal-binding site 1132496002847 UvrB/uvrC motif; Region: UVR; pfam02151 1132496002848 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1132496002849 Helix-hairpin-helix motif; Region: HHH; pfam00633 1132496002850 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1132496002851 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1132496002852 Ligand binding site; other site 1132496002853 oligomer interface; other site 1132496002854 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1132496002855 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1132496002856 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1132496002857 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1132496002858 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1132496002859 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1132496002860 Walker A/P-loop; other site 1132496002861 ATP binding site [chemical binding]; other site 1132496002862 Q-loop/lid; other site 1132496002863 ABC transporter signature motif; other site 1132496002864 Walker B; other site 1132496002865 D-loop; other site 1132496002866 H-loop/switch region; other site 1132496002867 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1132496002868 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1132496002869 Competence protein; Region: Competence; pfam03772 1132496002870 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1132496002871 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1132496002872 poly(A) polymerase; Region: pcnB; TIGR01942 1132496002873 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1132496002874 active site 1132496002875 NTP binding site [chemical binding]; other site 1132496002876 metal binding triad [ion binding]; metal-binding site 1132496002877 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1132496002878 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1132496002879 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1132496002880 catalytic center binding site [active] 1132496002881 ATP binding site [chemical binding]; other site 1132496002882 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1132496002883 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1132496002884 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1132496002885 putative active site [active] 1132496002886 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1132496002887 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1132496002888 DNA binding site [nucleotide binding] 1132496002889 domain linker motif; other site 1132496002890 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1132496002891 dimerization interface [polypeptide binding]; other site 1132496002892 ligand binding site [chemical binding]; other site 1132496002893 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1132496002894 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1132496002895 putative valine binding site [chemical binding]; other site 1132496002896 dimer interface [polypeptide binding]; other site 1132496002897 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1132496002898 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06882 1132496002899 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1132496002900 PYR/PP interface [polypeptide binding]; other site 1132496002901 dimer interface [polypeptide binding]; other site 1132496002902 TPP binding site [chemical binding]; other site 1132496002903 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1132496002904 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1132496002905 TPP-binding site [chemical binding]; other site 1132496002906 dimer interface [polypeptide binding]; other site 1132496002907 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1132496002908 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 1132496002909 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1132496002910 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1132496002911 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1132496002912 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1132496002913 putative active site [active] 1132496002914 putative substrate binding site [chemical binding]; other site 1132496002915 putative cosubstrate binding site; other site 1132496002916 catalytic site [active] 1132496002917 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1132496002918 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1132496002919 active site 1132496002920 dimer interface [polypeptide binding]; other site 1132496002921 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1132496002922 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1132496002923 active site 1132496002924 trimer interface [polypeptide binding]; other site 1132496002925 allosteric site; other site 1132496002926 active site lid [active] 1132496002927 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1132496002928 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1132496002929 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1132496002930 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1132496002931 active site turn [active] 1132496002932 phosphorylation site [posttranslational modification] 1132496002933 ABC transporter ATPase component; Reviewed; Region: PRK11147 1132496002934 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1132496002935 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1132496002936 ABC transporter; Region: ABC_tran_2; pfam12848 1132496002937 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1132496002938 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 1132496002939 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1132496002940 Zn2+ binding site [ion binding]; other site 1132496002941 Mg2+ binding site [ion binding]; other site 1132496002942 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1132496002943 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1132496002944 hypothetical protein; Provisional; Region: PRK01821 1132496002945 Staphylococcal nuclease homologues; Region: SNc; smart00318 1132496002946 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1132496002947 Catalytic site; other site 1132496002948 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1132496002949 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1132496002950 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1132496002951 catalytic residue [active] 1132496002952 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1132496002953 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1132496002954 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1132496002955 putative ribose interaction site [chemical binding]; other site 1132496002956 putative ADP binding site [chemical binding]; other site 1132496002957 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1132496002958 active site 1132496002959 nucleotide binding site [chemical binding]; other site 1132496002960 HIGH motif; other site 1132496002961 KMSKS motif; other site 1132496002962 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1132496002963 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1132496002964 putative acyl-acceptor binding pocket; other site 1132496002965 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1132496002966 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1132496002967 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1132496002968 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1132496002969 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1132496002970 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1132496002971 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496002972 Walker A/P-loop; other site 1132496002973 ATP binding site [chemical binding]; other site 1132496002974 Q-loop/lid; other site 1132496002975 ABC transporter signature motif; other site 1132496002976 Walker B; other site 1132496002977 D-loop; other site 1132496002978 H-loop/switch region; other site 1132496002979 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496002980 Walker A/P-loop; other site 1132496002981 ATP binding site [chemical binding]; other site 1132496002982 Q-loop/lid; other site 1132496002983 ABC transporter signature motif; other site 1132496002984 Walker B; other site 1132496002985 D-loop; other site 1132496002986 H-loop/switch region; other site 1132496002987 serine/threonine transporter SstT; Provisional; Region: PRK13628 1132496002988 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1132496002989 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1132496002990 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 1132496002991 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1132496002992 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1132496002993 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1132496002994 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1132496002995 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1132496002996 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1132496002997 E3 interaction surface; other site 1132496002998 lipoyl attachment site [posttranslational modification]; other site 1132496002999 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1132496003000 E3 interaction surface; other site 1132496003001 lipoyl attachment site [posttranslational modification]; other site 1132496003002 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1132496003003 E3 interaction surface; other site 1132496003004 lipoyl attachment site [posttranslational modification]; other site 1132496003005 e3 binding domain; Region: E3_binding; pfam02817 1132496003006 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1132496003007 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1132496003008 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1132496003009 dimer interface [polypeptide binding]; other site 1132496003010 TPP-binding site [chemical binding]; other site 1132496003011 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1132496003012 PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439 1132496003013 HPr interaction site; other site 1132496003014 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1132496003015 active site 1132496003016 phosphorylation site [posttranslational modification] 1132496003017 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1132496003018 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1132496003019 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1132496003020 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1132496003021 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1132496003022 dimerization domain swap beta strand [polypeptide binding]; other site 1132496003023 regulatory protein interface [polypeptide binding]; other site 1132496003024 active site 1132496003025 regulatory phosphorylation site [posttranslational modification]; other site 1132496003026 GTPase RsgA; Reviewed; Region: PRK12288 1132496003027 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1132496003028 RNA binding site [nucleotide binding]; other site 1132496003029 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1132496003030 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1132496003031 GTP/Mg2+ binding site [chemical binding]; other site 1132496003032 G4 box; other site 1132496003033 G5 box; other site 1132496003034 G1 box; other site 1132496003035 Switch I region; other site 1132496003036 G2 box; other site 1132496003037 G3 box; other site 1132496003038 Switch II region; other site 1132496003039 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1132496003040 catalytic site [active] 1132496003041 putative active site [active] 1132496003042 putative substrate binding site [chemical binding]; other site 1132496003043 dimer interface [polypeptide binding]; other site 1132496003044 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1132496003045 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1132496003046 active site 1132496003047 metal binding site [ion binding]; metal-binding site 1132496003048 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1132496003049 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1132496003050 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1132496003051 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 1132496003052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1132496003053 ATP binding site [chemical binding]; other site 1132496003054 Mg2+ binding site [ion binding]; other site 1132496003055 G-X-G motif; other site 1132496003056 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1132496003057 ATP binding site [chemical binding]; other site 1132496003058 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1132496003059 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1132496003060 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1132496003061 bacterial Hfq-like; Region: Hfq; cd01716 1132496003062 hexamer interface [polypeptide binding]; other site 1132496003063 Sm1 motif; other site 1132496003064 RNA binding site [nucleotide binding]; other site 1132496003065 Sm2 motif; other site 1132496003066 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 1132496003067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1132496003068 Walker A motif; other site 1132496003069 ATP binding site [chemical binding]; other site 1132496003070 Walker B motif; other site 1132496003071 arginine finger; other site 1132496003072 Predicted membrane protein [Function unknown]; Region: COG3768 1132496003073 Domain of unknown function (DUF697); Region: DUF697; cl12064 1132496003074 Predicted ATPase [General function prediction only]; Region: COG3106 1132496003075 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1132496003076 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1132496003077 peptide binding site [polypeptide binding]; other site 1132496003078 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168 1132496003079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496003080 dimer interface [polypeptide binding]; other site 1132496003081 conserved gate region; other site 1132496003082 putative PBP binding loops; other site 1132496003083 ABC-ATPase subunit interface; other site 1132496003084 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 1132496003085 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1132496003086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496003087 dimer interface [polypeptide binding]; other site 1132496003088 conserved gate region; other site 1132496003089 putative PBP binding loops; other site 1132496003090 ABC-ATPase subunit interface; other site 1132496003091 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170 1132496003092 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1132496003093 Walker A/P-loop; other site 1132496003094 ATP binding site [chemical binding]; other site 1132496003095 Q-loop/lid; other site 1132496003096 ABC transporter signature motif; other site 1132496003097 Walker B; other site 1132496003098 D-loop; other site 1132496003099 H-loop/switch region; other site 1132496003100 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1132496003101 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167 1132496003102 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1132496003103 Walker A/P-loop; other site 1132496003104 ATP binding site [chemical binding]; other site 1132496003105 Q-loop/lid; other site 1132496003106 ABC transporter signature motif; other site 1132496003107 Walker B; other site 1132496003108 D-loop; other site 1132496003109 H-loop/switch region; other site 1132496003110 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1132496003111 classical (c) SDRs; Region: SDR_c; cd05233 1132496003112 NAD(P) binding site [chemical binding]; other site 1132496003113 active site 1132496003114 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1132496003115 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1132496003116 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1132496003117 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1132496003118 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1132496003119 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1132496003120 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1132496003121 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1132496003122 active site 1132496003123 GMP synthase; Reviewed; Region: guaA; PRK00074 1132496003124 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1132496003125 AMP/PPi binding site [chemical binding]; other site 1132496003126 candidate oxyanion hole; other site 1132496003127 catalytic triad [active] 1132496003128 potential glutamine specificity residues [chemical binding]; other site 1132496003129 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1132496003130 ATP Binding subdomain [chemical binding]; other site 1132496003131 Ligand Binding sites [chemical binding]; other site 1132496003132 Dimerization subdomain; other site 1132496003133 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 1132496003134 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1132496003135 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1132496003136 pyridoxamine kinase; Validated; Region: PRK05756 1132496003137 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1132496003138 pyridoxal binding site [chemical binding]; other site 1132496003139 dimer interface [polypeptide binding]; other site 1132496003140 ATP binding site [chemical binding]; other site 1132496003141 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1132496003142 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1132496003143 Ligand Binding Site [chemical binding]; other site 1132496003144 TilS substrate binding domain; Region: TilS; pfam09179 1132496003145 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1132496003146 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1132496003147 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1132496003148 phosphate binding site [ion binding]; other site 1132496003149 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1132496003150 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1132496003151 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1132496003152 NAD binding site [chemical binding]; other site 1132496003153 homodimer interface [polypeptide binding]; other site 1132496003154 active site 1132496003155 substrate binding site [chemical binding]; other site 1132496003156 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1132496003157 AmpG-like permease; Region: 2A0125; TIGR00901 1132496003158 adenylate kinase; Reviewed; Region: adk; PRK00279 1132496003159 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1132496003160 AMP-binding site [chemical binding]; other site 1132496003161 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1132496003162 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1132496003163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1132496003164 motif II; other site 1132496003165 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1132496003166 CoA binding domain; Region: CoA_binding; smart00881 1132496003167 CoA-ligase; Region: Ligase_CoA; pfam00549 1132496003168 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1132496003169 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1132496003170 CoA-ligase; Region: Ligase_CoA; pfam00549 1132496003171 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1132496003172 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1132496003173 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1132496003174 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1132496003175 E3 interaction surface; other site 1132496003176 lipoyl attachment site [posttranslational modification]; other site 1132496003177 e3 binding domain; Region: E3_binding; pfam02817 1132496003178 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1132496003179 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1132496003180 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1132496003181 TPP-binding site [chemical binding]; other site 1132496003182 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1132496003183 dimer interface [polypeptide binding]; other site 1132496003184 PYR/PP interface [polypeptide binding]; other site 1132496003185 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1132496003186 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1132496003187 dimer interface [polypeptide binding]; other site 1132496003188 active site 1132496003189 citrylCoA binding site [chemical binding]; other site 1132496003190 NADH binding [chemical binding]; other site 1132496003191 cationic pore residues; other site 1132496003192 oxalacetate/citrate binding site [chemical binding]; other site 1132496003193 coenzyme A binding site [chemical binding]; other site 1132496003194 catalytic triad [active] 1132496003195 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1132496003196 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1132496003197 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1132496003198 DctM-like transporters; Region: DctM; pfam06808 1132496003199 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1132496003200 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1132496003201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1132496003202 Peptidase M15; Region: Peptidase_M15_3; cl01194 1132496003203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 1132496003204 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1132496003205 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1132496003206 carboxy-terminal protease; Provisional; Region: PRK11186 1132496003207 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1132496003208 protein binding site [polypeptide binding]; other site 1132496003209 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1132496003210 Catalytic dyad [active] 1132496003211 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1132496003212 ProP expression regulator; Provisional; Region: PRK04950 1132496003213 ProQ/FINO family; Region: ProQ; pfam04352 1132496003214 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 1132496003215 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1132496003216 Paraquat-inducible protein A; Region: PqiA; pfam04403 1132496003217 Paraquat-inducible protein A; Region: PqiA; pfam04403 1132496003218 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1132496003219 mce related protein; Region: MCE; pfam02470 1132496003220 mce related protein; Region: MCE; pfam02470 1132496003221 mce related protein; Region: MCE; pfam02470 1132496003222 mce related protein; Region: MCE; pfam02470 1132496003223 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1132496003224 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1132496003225 metal binding site [ion binding]; metal-binding site 1132496003226 dimer interface [polypeptide binding]; other site 1132496003227 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 1132496003228 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1132496003229 Walker A/P-loop; other site 1132496003230 ATP binding site [chemical binding]; other site 1132496003231 Q-loop/lid; other site 1132496003232 ABC transporter signature motif; other site 1132496003233 Walker B; other site 1132496003234 D-loop; other site 1132496003235 H-loop/switch region; other site 1132496003236 TOBE domain; Region: TOBE_2; pfam08402 1132496003237 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1132496003238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496003239 dimer interface [polypeptide binding]; other site 1132496003240 conserved gate region; other site 1132496003241 putative PBP binding loops; other site 1132496003242 ABC-ATPase subunit interface; other site 1132496003243 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1132496003244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496003245 dimer interface [polypeptide binding]; other site 1132496003246 conserved gate region; other site 1132496003247 ABC-ATPase subunit interface; other site 1132496003248 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1132496003249 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1132496003250 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1132496003251 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1132496003252 cytidine deaminase; Provisional; Region: PRK09027 1132496003253 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1132496003254 active site 1132496003255 catalytic motif [active] 1132496003256 Zn binding site [ion binding]; other site 1132496003257 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1132496003258 active site 1132496003259 catalytic motif [active] 1132496003260 Zn binding site [ion binding]; other site 1132496003261 seryl-tRNA synthetase; Provisional; Region: PRK05431 1132496003262 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1132496003263 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1132496003264 dimer interface [polypeptide binding]; other site 1132496003265 active site 1132496003266 motif 1; other site 1132496003267 motif 2; other site 1132496003268 motif 3; other site 1132496003269 recombination factor protein RarA; Reviewed; Region: PRK13342 1132496003270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1132496003271 Walker A motif; other site 1132496003272 ATP binding site [chemical binding]; other site 1132496003273 Walker B motif; other site 1132496003274 arginine finger; other site 1132496003275 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1132496003276 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1132496003277 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1132496003278 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1132496003279 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1132496003280 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1132496003281 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1132496003282 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1132496003283 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1132496003284 putative DNA binding site [nucleotide binding]; other site 1132496003285 dimerization interface [polypeptide binding]; other site 1132496003286 putative Zn2+ binding site [ion binding]; other site 1132496003287 AsnC family; Region: AsnC_trans_reg; pfam01037 1132496003288 DNA repair protein RadA; Provisional; Region: PRK11823 1132496003289 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1132496003290 Walker A motif; other site 1132496003291 ATP binding site [chemical binding]; other site 1132496003292 Walker B motif; other site 1132496003293 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1132496003294 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1132496003295 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1132496003296 putative active site [active] 1132496003297 putative metal binding residues [ion binding]; other site 1132496003298 signature motif; other site 1132496003299 putative triphosphate binding site [ion binding]; other site 1132496003300 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1132496003301 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1132496003302 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1132496003303 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1132496003304 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1132496003305 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1132496003306 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1132496003307 active site 1132496003308 NTP binding site [chemical binding]; other site 1132496003309 metal binding triad [ion binding]; metal-binding site 1132496003310 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1132496003311 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1132496003312 Zn2+ binding site [ion binding]; other site 1132496003313 Mg2+ binding site [ion binding]; other site 1132496003314 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 1132496003315 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1132496003316 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1132496003317 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1132496003318 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1132496003319 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1132496003320 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1132496003321 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1132496003322 active site 1132496003323 putative peptidase; Provisional; Region: PRK11649 1132496003324 Peptidase family M23; Region: Peptidase_M23; pfam01551 1132496003325 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1132496003326 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1132496003327 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1132496003328 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1132496003329 ABC-ATPase subunit interface; other site 1132496003330 dimer interface [polypeptide binding]; other site 1132496003331 putative PBP binding regions; other site 1132496003332 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1132496003333 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1132496003334 Walker A/P-loop; other site 1132496003335 ATP binding site [chemical binding]; other site 1132496003336 Q-loop/lid; other site 1132496003337 ABC transporter signature motif; other site 1132496003338 Walker B; other site 1132496003339 D-loop; other site 1132496003340 H-loop/switch region; other site 1132496003341 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1132496003342 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1132496003343 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1132496003344 Walker A/P-loop; other site 1132496003345 ATP binding site [chemical binding]; other site 1132496003346 Q-loop/lid; other site 1132496003347 ABC transporter signature motif; other site 1132496003348 Walker B; other site 1132496003349 D-loop; other site 1132496003350 H-loop/switch region; other site 1132496003351 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1132496003352 dipeptide transporter; Provisional; Region: PRK10913 1132496003353 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1132496003354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496003355 dimer interface [polypeptide binding]; other site 1132496003356 conserved gate region; other site 1132496003357 putative PBP binding loops; other site 1132496003358 ABC-ATPase subunit interface; other site 1132496003359 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1132496003360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496003361 dimer interface [polypeptide binding]; other site 1132496003362 conserved gate region; other site 1132496003363 putative PBP binding loops; other site 1132496003364 ABC-ATPase subunit interface; other site 1132496003365 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1132496003366 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1132496003367 peptide binding site [polypeptide binding]; other site 1132496003368 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1132496003369 FAD binding site [chemical binding]; other site 1132496003370 putative protease; Provisional; Region: PRK15452 1132496003371 Peptidase family U32; Region: Peptidase_U32; pfam01136 1132496003372 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1132496003373 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1132496003374 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1132496003375 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1132496003376 active site 1132496003377 motif I; other site 1132496003378 motif II; other site 1132496003379 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1132496003380 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1132496003381 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1132496003382 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1132496003383 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1132496003384 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1132496003385 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1132496003386 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1132496003387 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1132496003388 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1132496003389 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1132496003390 Protein export membrane protein; Region: SecD_SecF; pfam02355 1132496003391 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1132496003392 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1132496003393 dimer interface [polypeptide binding]; other site 1132496003394 active site 1132496003395 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1132496003396 folate binding site [chemical binding]; other site 1132496003397 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1132496003398 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1132496003399 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1132496003400 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1132496003401 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1132496003402 Sulfatase; Region: Sulfatase; pfam00884 1132496003403 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1132496003404 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1132496003405 purine monophosphate binding site [chemical binding]; other site 1132496003406 dimer interface [polypeptide binding]; other site 1132496003407 putative catalytic residues [active] 1132496003408 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1132496003409 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1132496003410 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1132496003411 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1132496003412 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1132496003413 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1132496003414 DsbD alpha interface [polypeptide binding]; other site 1132496003415 catalytic residues [active] 1132496003416 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1132496003417 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1132496003418 two-component response regulator; Provisional; Region: PRK11173 1132496003419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1132496003420 active site 1132496003421 phosphorylation site [posttranslational modification] 1132496003422 intermolecular recognition site; other site 1132496003423 dimerization interface [polypeptide binding]; other site 1132496003424 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1132496003425 DNA binding site [nucleotide binding] 1132496003426 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1132496003427 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1132496003428 SmpB-tmRNA interface; other site 1132496003429 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1132496003430 sensor protein QseC; Provisional; Region: PRK10337 1132496003431 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1132496003432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1132496003433 dimer interface [polypeptide binding]; other site 1132496003434 phosphorylation site [posttranslational modification] 1132496003435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1132496003436 ATP binding site [chemical binding]; other site 1132496003437 Mg2+ binding site [ion binding]; other site 1132496003438 G-X-G motif; other site 1132496003439 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1132496003440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1132496003441 active site 1132496003442 phosphorylation site [posttranslational modification] 1132496003443 intermolecular recognition site; other site 1132496003444 dimerization interface [polypeptide binding]; other site 1132496003445 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1132496003446 DNA binding site [nucleotide binding] 1132496003447 Predicted membrane protein [Function unknown]; Region: COG2259 1132496003448 Uncharacterized low-complexity protein [Function unknown]; Region: COG3767 1132496003449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3220 1132496003450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3219 1132496003451 RNA polymerase sigma factor; Provisional; Region: PRK12530 1132496003452 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1132496003453 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1132496003454 DNA binding residues [nucleotide binding] 1132496003455 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1132496003456 DNA topoisomerase III; Provisional; Region: PRK07726 1132496003457 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1132496003458 active site 1132496003459 putative interdomain interaction site [polypeptide binding]; other site 1132496003460 putative metal-binding site [ion binding]; other site 1132496003461 putative nucleotide binding site [chemical binding]; other site 1132496003462 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1132496003463 domain I; other site 1132496003464 phosphate binding site [ion binding]; other site 1132496003465 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1132496003466 domain II; other site 1132496003467 domain III; other site 1132496003468 nucleotide binding site [chemical binding]; other site 1132496003469 DNA binding groove [nucleotide binding] 1132496003470 catalytic site [active] 1132496003471 domain IV; other site 1132496003472 recombination protein RecR; Reviewed; Region: recR; PRK00076 1132496003473 RecR protein; Region: RecR; pfam02132 1132496003474 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1132496003475 putative active site [active] 1132496003476 putative metal-binding site [ion binding]; other site 1132496003477 tetramer interface [polypeptide binding]; other site 1132496003478 hypothetical protein; Validated; Region: PRK00153 1132496003479 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1132496003480 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1132496003481 substrate binding site [chemical binding]; other site 1132496003482 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1132496003483 substrate binding site [chemical binding]; other site 1132496003484 ligand binding site [chemical binding]; other site 1132496003485 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1132496003486 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1132496003487 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1132496003488 poxB regulator PoxA; Provisional; Region: PRK09350 1132496003489 motif 1; other site 1132496003490 dimer interface [polypeptide binding]; other site 1132496003491 active site 1132496003492 motif 2; other site 1132496003493 motif 3; other site 1132496003494 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1132496003495 L-aspartate oxidase; Provisional; Region: PRK06175 1132496003496 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1132496003497 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1132496003498 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1132496003499 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1132496003500 D-subunit interface [polypeptide binding]; other site 1132496003501 Iron-sulfur protein interface; other site 1132496003502 proximal quinone binding site [chemical binding]; other site 1132496003503 distal quinone binding site [chemical binding]; other site 1132496003504 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1132496003505 Iron-sulfur protein interface; other site 1132496003506 proximal quinone binding site [chemical binding]; other site 1132496003507 C-subunit interface; other site 1132496003508 distal quinone binding site; other site 1132496003509 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1132496003510 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1132496003511 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1132496003512 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1132496003513 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1132496003514 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1132496003515 interface (dimer of trimers) [polypeptide binding]; other site 1132496003516 Substrate-binding/catalytic site; other site 1132496003517 Zn-binding sites [ion binding]; other site 1132496003518 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1132496003519 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1132496003520 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1132496003521 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1132496003522 catalytic residues [active] 1132496003523 alpha helical domain; other site 1132496003524 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1132496003525 DHH family; Region: DHH; pfam01368 1132496003526 DHHA1 domain; Region: DHHA1; pfam02272 1132496003527 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1132496003528 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1132496003529 dimerization domain [polypeptide binding]; other site 1132496003530 dimer interface [polypeptide binding]; other site 1132496003531 catalytic residues [active] 1132496003532 peptide chain release factor 2; Provisional; Region: PRK08787 1132496003533 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1132496003534 RF-1 domain; Region: RF-1; pfam00472 1132496003535 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1132496003536 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1132496003537 dimer interface [polypeptide binding]; other site 1132496003538 putative anticodon binding site; other site 1132496003539 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1132496003540 motif 1; other site 1132496003541 active site 1132496003542 motif 2; other site 1132496003543 motif 3; other site 1132496003544 Sialyltransferase PMO188; Region: PM0188; pfam11477 1132496003545 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1132496003546 ligand binding site; other site 1132496003547 tetramer interface; other site 1132496003548 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1132496003549 Ligand Binding Site [chemical binding]; other site 1132496003550 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1132496003551 active site 1132496003552 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1132496003553 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1132496003554 FeS/SAM binding site; other site 1132496003555 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1132496003556 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1132496003557 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1132496003558 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1132496003559 NAD binding site [chemical binding]; other site 1132496003560 homotetramer interface [polypeptide binding]; other site 1132496003561 homodimer interface [polypeptide binding]; other site 1132496003562 substrate binding site [chemical binding]; other site 1132496003563 active site 1132496003564 exoribonuclease II; Provisional; Region: PRK05054 1132496003565 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1132496003566 RNB domain; Region: RNB; pfam00773 1132496003567 S1 RNA binding domain; Region: S1; pfam00575 1132496003568 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1132496003569 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1132496003570 hinge; other site 1132496003571 active site 1132496003572 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1132496003573 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1132496003574 anti sigma factor interaction site; other site 1132496003575 regulatory phosphorylation site [posttranslational modification]; other site 1132496003576 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; COG2854 1132496003577 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1132496003578 mce related protein; Region: MCE; pfam02470 1132496003579 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1132496003580 conserved hypothetical integral membrane protein; Region: TIGR00056 1132496003581 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1132496003582 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1132496003583 Walker A/P-loop; other site 1132496003584 ATP binding site [chemical binding]; other site 1132496003585 Q-loop/lid; other site 1132496003586 ABC transporter signature motif; other site 1132496003587 Walker B; other site 1132496003588 D-loop; other site 1132496003589 H-loop/switch region; other site 1132496003590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 1132496003591 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1132496003592 OstA-like protein; Region: OstA; cl00844 1132496003593 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1132496003594 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1132496003595 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1132496003596 Walker A/P-loop; other site 1132496003597 ATP binding site [chemical binding]; other site 1132496003598 Q-loop/lid; other site 1132496003599 ABC transporter signature motif; other site 1132496003600 Walker B; other site 1132496003601 D-loop; other site 1132496003602 H-loop/switch region; other site 1132496003603 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1132496003604 active site 1132496003605 phosphorylation site [posttranslational modification] 1132496003606 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1132496003607 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1132496003608 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1132496003609 generic binding surface II; other site 1132496003610 generic binding surface I; other site 1132496003611 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1132496003612 hypothetical protein; Validated; Region: PRK01777 1132496003613 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1132496003614 putative coenzyme Q binding site [chemical binding]; other site 1132496003615 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1132496003616 putative active site [active] 1132496003617 catalytic residue [active] 1132496003618 GTP-binding protein YchF; Reviewed; Region: PRK09601 1132496003619 YchF GTPase; Region: YchF; cd01900 1132496003620 G1 box; other site 1132496003621 GTP/Mg2+ binding site [chemical binding]; other site 1132496003622 Switch I region; other site 1132496003623 G2 box; other site 1132496003624 Switch II region; other site 1132496003625 G3 box; other site 1132496003626 G4 box; other site 1132496003627 G5 box; other site 1132496003628 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1132496003629 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1132496003630 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1132496003631 dimer interface [polypeptide binding]; other site 1132496003632 FMN binding site [chemical binding]; other site 1132496003633 allantoate amidohydrolase; Reviewed; Region: PRK09290 1132496003634 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1132496003635 active site 1132496003636 metal binding site [ion binding]; metal-binding site 1132496003637 dimer interface [polypeptide binding]; other site 1132496003638 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 1132496003639 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1132496003640 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1132496003641 PhnA protein; Region: PhnA; pfam03831 1132496003642 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 1132496003643 D-ribose pyranase; Provisional; Region: PRK11797 1132496003644 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1132496003645 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1132496003646 Walker A/P-loop; other site 1132496003647 ATP binding site [chemical binding]; other site 1132496003648 Q-loop/lid; other site 1132496003649 ABC transporter signature motif; other site 1132496003650 Walker B; other site 1132496003651 D-loop; other site 1132496003652 H-loop/switch region; other site 1132496003653 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1132496003654 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1132496003655 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1132496003656 TM-ABC transporter signature motif; other site 1132496003657 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1132496003658 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1132496003659 ligand binding site [chemical binding]; other site 1132496003660 dimerization interface [polypeptide binding]; other site 1132496003661 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1132496003662 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1132496003663 substrate binding site [chemical binding]; other site 1132496003664 dimer interface [polypeptide binding]; other site 1132496003665 ATP binding site [chemical binding]; other site 1132496003666 transcriptional repressor RbsR; Provisional; Region: PRK10423 1132496003667 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1132496003668 DNA binding site [nucleotide binding] 1132496003669 domain linker motif; other site 1132496003670 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1132496003671 dimerization interface [polypeptide binding]; other site 1132496003672 ligand binding site [chemical binding]; other site 1132496003673 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1132496003674 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1132496003675 Prephenate dehydratase; Region: PDT; pfam00800 1132496003676 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1132496003677 putative L-Phe binding site [chemical binding]; other site 1132496003678 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1132496003679 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1132496003680 dimer interface [polypeptide binding]; other site 1132496003681 active site 1132496003682 metal binding site [ion binding]; metal-binding site 1132496003683 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1132496003684 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1132496003685 cell division protein FtsZ; Validated; Region: PRK09330 1132496003686 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1132496003687 nucleotide binding site [chemical binding]; other site 1132496003688 SulA interaction site; other site 1132496003689 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1132496003690 Cell division protein FtsA; Region: FtsA; smart00842 1132496003691 Cell division protein FtsA; Region: FtsA; pfam14450 1132496003692 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1132496003693 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1132496003694 Cell division protein FtsQ; Region: FtsQ; pfam03799 1132496003695 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1132496003696 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1132496003697 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1132496003698 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1132496003699 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1132496003700 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1132496003701 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1132496003702 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1132496003703 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1132496003704 active site 1132496003705 homodimer interface [polypeptide binding]; other site 1132496003706 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1132496003707 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1132496003708 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 1132496003709 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1132496003710 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1132496003711 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1132496003712 Mg++ binding site [ion binding]; other site 1132496003713 putative catalytic motif [active] 1132496003714 putative substrate binding site [chemical binding]; other site 1132496003715 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1132496003716 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1132496003717 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1132496003718 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1132496003719 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1132496003720 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1132496003721 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1132496003722 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1132496003723 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1132496003724 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1132496003725 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1132496003726 Cell division protein [Cell division and chromosome partitioning]; Region: FtsL; COG3116 1132496003727 MraW methylase family; Region: Methyltransf_5; pfam01795 1132496003728 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1132496003729 cell division protein MraZ; Reviewed; Region: PRK00326 1132496003730 MraZ protein; Region: MraZ; pfam02381 1132496003731 MraZ protein; Region: MraZ; pfam02381 1132496003732 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1132496003733 Carbon starvation protein CstA; Region: CstA; pfam02554 1132496003734 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1132496003735 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 1132496003736 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1132496003737 siderophore binding site; other site 1132496003738 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1132496003739 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1132496003740 ABC-ATPase subunit interface; other site 1132496003741 dimer interface [polypeptide binding]; other site 1132496003742 putative PBP binding regions; other site 1132496003743 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1132496003744 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1132496003745 ABC-ATPase subunit interface; other site 1132496003746 dimer interface [polypeptide binding]; other site 1132496003747 putative PBP binding regions; other site 1132496003748 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 1132496003749 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1132496003750 Walker A/P-loop; other site 1132496003751 ATP binding site [chemical binding]; other site 1132496003752 Q-loop/lid; other site 1132496003753 ABC transporter signature motif; other site 1132496003754 Walker B; other site 1132496003755 D-loop; other site 1132496003756 H-loop/switch region; other site 1132496003757 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 1132496003758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496003759 dimer interface [polypeptide binding]; other site 1132496003760 conserved gate region; other site 1132496003761 putative PBP binding loops; other site 1132496003762 ABC-ATPase subunit interface; other site 1132496003763 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1132496003764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496003765 dimer interface [polypeptide binding]; other site 1132496003766 conserved gate region; other site 1132496003767 putative PBP binding loops; other site 1132496003768 ABC-ATPase subunit interface; other site 1132496003769 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1132496003770 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1132496003771 substrate binding pocket [chemical binding]; other site 1132496003772 membrane-bound complex binding site; other site 1132496003773 hinge residues; other site 1132496003774 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1132496003775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496003776 Walker A/P-loop; other site 1132496003777 ATP binding site [chemical binding]; other site 1132496003778 Q-loop/lid; other site 1132496003779 ABC transporter signature motif; other site 1132496003780 Walker B; other site 1132496003781 D-loop; other site 1132496003782 H-loop/switch region; other site 1132496003783 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1132496003784 dimer interface [polypeptide binding]; other site 1132496003785 active site 1132496003786 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1132496003787 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1132496003788 active site 1132496003789 peptidase PmbA; Provisional; Region: PRK11040 1132496003790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3028 1132496003791 FtsH protease regulator HflC; Provisional; Region: PRK11029 1132496003792 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1132496003793 FtsH protease regulator HflK; Provisional; Region: PRK10930 1132496003794 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1132496003795 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1132496003796 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1132496003797 threonine synthase; Validated; Region: PRK09225 1132496003798 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1132496003799 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1132496003800 catalytic residue [active] 1132496003801 homoserine kinase; Provisional; Region: PRK01212 1132496003802 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1132496003803 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1132496003804 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1132496003805 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1132496003806 nucleotide binding site [chemical binding]; other site 1132496003807 substrate binding site [chemical binding]; other site 1132496003808 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1132496003809 dimer interface [polypeptide binding]; other site 1132496003810 putative threonine allosteric regulatory site; other site 1132496003811 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1132496003812 putative threonine allosteric regulatory site; other site 1132496003813 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1132496003814 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1132496003815 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1132496003816 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1132496003817 catalytic residue [active] 1132496003818 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1132496003819 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1132496003820 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1132496003821 RNA/DNA hybrid binding site [nucleotide binding]; other site 1132496003822 active site 1132496003823 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1132496003824 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1132496003825 active site 1132496003826 catalytic site [active] 1132496003827 substrate binding site [chemical binding]; other site 1132496003828 GTP-binding protein Der; Reviewed; Region: PRK00093 1132496003829 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1132496003830 G1 box; other site 1132496003831 GTP/Mg2+ binding site [chemical binding]; other site 1132496003832 Switch I region; other site 1132496003833 G2 box; other site 1132496003834 Switch II region; other site 1132496003835 G3 box; other site 1132496003836 G4 box; other site 1132496003837 G5 box; other site 1132496003838 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1132496003839 G1 box; other site 1132496003840 GTP/Mg2+ binding site [chemical binding]; other site 1132496003841 Switch I region; other site 1132496003842 G2 box; other site 1132496003843 G3 box; other site 1132496003844 Switch II region; other site 1132496003845 G4 box; other site 1132496003846 G5 box; other site 1132496003847 FtsI repressor; Provisional; Region: PRK10883 1132496003848 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1132496003849 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1132496003850 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1132496003851 putative acyl-acceptor binding pocket; other site 1132496003852 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1132496003853 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1132496003854 putative active site [active] 1132496003855 putative metal binding site [ion binding]; other site 1132496003856 Uncharacterized integral membrane protein [Function unknown]; Region: COG5413 1132496003857 elongation factor P; Validated; Region: PRK00529 1132496003858 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1132496003859 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1132496003860 RNA binding site [nucleotide binding]; other site 1132496003861 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1132496003862 RNA binding site [nucleotide binding]; other site 1132496003863 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1132496003864 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1132496003865 FeS/SAM binding site; other site 1132496003866 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 1132496003867 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1132496003868 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1132496003869 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 1132496003870 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1132496003871 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1132496003872 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1132496003873 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1132496003874 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1132496003875 active site 1132496003876 Int/Topo IB signature motif; other site 1132496003877 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1132496003878 30S subunit binding site; other site 1132496003879 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1132496003880 amino acid carrier protein; Region: agcS; TIGR00835 1132496003881 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1132496003882 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1132496003883 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1132496003884 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1132496003885 CoA-binding site [chemical binding]; other site 1132496003886 ATP-binding [chemical binding]; other site 1132496003887 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1132496003888 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1132496003889 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1132496003890 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1132496003891 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1132496003892 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1132496003893 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1132496003894 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1132496003895 Walker A motif; other site 1132496003896 ATP binding site [chemical binding]; other site 1132496003897 Walker B motif; other site 1132496003898 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 1132496003899 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1132496003900 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1132496003901 amidase catalytic site [active] 1132496003902 Zn binding residues [ion binding]; other site 1132496003903 substrate binding site [chemical binding]; other site 1132496003904 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1132496003905 putative active site [active] 1132496003906 Ap4A binding site [chemical binding]; other site 1132496003907 nudix motif; other site 1132496003908 putative metal binding site [ion binding]; other site 1132496003909 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1132496003910 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1132496003911 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1132496003912 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1132496003913 dimerization interface [polypeptide binding]; other site 1132496003914 active site 1132496003915 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1132496003916 nucleoside/Zn binding site; other site 1132496003917 dimer interface [polypeptide binding]; other site 1132496003918 catalytic motif [active] 1132496003919 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1132496003920 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1132496003921 FeS/SAM binding site; other site 1132496003922 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1132496003923 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 1132496003924 active site 1132496003925 oxyanion hole [active] 1132496003926 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1132496003927 catalytic triad [active] 1132496003928 Autotransporter beta-domain; Region: Autotransporter; cl17461 1132496003929 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1132496003930 Pyruvate formate lyase 1; Region: PFL1; cd01678 1132496003931 coenzyme A binding site [chemical binding]; other site 1132496003932 active site 1132496003933 catalytic residues [active] 1132496003934 glycine loop; other site 1132496003935 formate transporter FocA; Region: formate_focA; TIGR04060 1132496003936 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1132496003937 nucleotide binding site/active site [active] 1132496003938 HIT family signature motif; other site 1132496003939 catalytic residue [active] 1132496003940 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 1132496003941 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1132496003942 putative dimer interface [polypeptide binding]; other site 1132496003943 beta-hexosaminidase; Provisional; Region: PRK05337 1132496003944 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1132496003945 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 1132496003946 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1132496003947 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1132496003948 active site 1132496003949 ADP/pyrophosphate binding site [chemical binding]; other site 1132496003950 dimerization interface [polypeptide binding]; other site 1132496003951 allosteric effector site; other site 1132496003952 fructose-1,6-bisphosphate binding site; other site 1132496003953 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1132496003954 Cation efflux family; Region: Cation_efflux; cl00316 1132496003955 hypothetical protein; Validated; Region: PRK02101 1132496003956 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1132496003957 ligand binding site [chemical binding]; other site 1132496003958 active site 1132496003959 UGI interface [polypeptide binding]; other site 1132496003960 catalytic site [active] 1132496003961 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1132496003962 GTP-binding protein LepA; Provisional; Region: PRK05433 1132496003963 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1132496003964 G1 box; other site 1132496003965 putative GEF interaction site [polypeptide binding]; other site 1132496003966 GTP/Mg2+ binding site [chemical binding]; other site 1132496003967 Switch I region; other site 1132496003968 G2 box; other site 1132496003969 G3 box; other site 1132496003970 Switch II region; other site 1132496003971 G4 box; other site 1132496003972 G5 box; other site 1132496003973 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1132496003974 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1132496003975 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1132496003976 signal peptidase I; Provisional; Region: PRK10861 1132496003977 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1132496003978 Catalytic site [active] 1132496003979 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1132496003980 ribonuclease III; Reviewed; Region: rnc; PRK00102 1132496003981 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1132496003982 dimerization interface [polypeptide binding]; other site 1132496003983 active site 1132496003984 metal binding site [ion binding]; metal-binding site 1132496003985 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1132496003986 dsRNA binding site [nucleotide binding]; other site 1132496003987 GTPase Era; Reviewed; Region: era; PRK00089 1132496003988 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1132496003989 G1 box; other site 1132496003990 GTP/Mg2+ binding site [chemical binding]; other site 1132496003991 Switch I region; other site 1132496003992 G2 box; other site 1132496003993 Switch II region; other site 1132496003994 G3 box; other site 1132496003995 G4 box; other site 1132496003996 G5 box; other site 1132496003997 KH domain; Region: KH_2; pfam07650 1132496003998 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1132496003999 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1132496004000 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1132496004001 dimer interface [polypeptide binding]; other site 1132496004002 tetramer interface [polypeptide binding]; other site 1132496004003 PYR/PP interface [polypeptide binding]; other site 1132496004004 TPP binding site [chemical binding]; other site 1132496004005 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1132496004006 TPP-binding site; other site 1132496004007 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1132496004008 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1132496004009 aminotransferase AlaT; Validated; Region: PRK09265 1132496004010 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1132496004011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1132496004012 homodimer interface [polypeptide binding]; other site 1132496004013 catalytic residue [active] 1132496004014 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1132496004015 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1132496004016 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1132496004017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496004018 dimer interface [polypeptide binding]; other site 1132496004019 conserved gate region; other site 1132496004020 putative PBP binding loops; other site 1132496004021 ABC-ATPase subunit interface; other site 1132496004022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496004023 dimer interface [polypeptide binding]; other site 1132496004024 conserved gate region; other site 1132496004025 putative PBP binding loops; other site 1132496004026 ABC-ATPase subunit interface; other site 1132496004027 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1132496004028 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1132496004029 Walker A/P-loop; other site 1132496004030 ATP binding site [chemical binding]; other site 1132496004031 Q-loop/lid; other site 1132496004032 ABC transporter signature motif; other site 1132496004033 Walker B; other site 1132496004034 D-loop; other site 1132496004035 H-loop/switch region; other site 1132496004036 fatty acid metabolism regulator; Provisional; Region: PRK04984 1132496004037 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1132496004038 DNA-binding site [nucleotide binding]; DNA binding site 1132496004039 FadR C-terminal domain; Region: FadR_C; pfam07840 1132496004040 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 1132496004041 disulfide bond formation protein B; Provisional; Region: PRK01749 1132496004042 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1132496004043 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1132496004044 substrate binding pocket [chemical binding]; other site 1132496004045 membrane-bound complex binding site; other site 1132496004046 hinge residues; other site 1132496004047 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1132496004048 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1132496004049 catalytic residue [active] 1132496004050 hypothetical protein; Provisional; Region: PRK11111 1132496004051 glutamate dehydrogenase; Provisional; Region: PRK09414 1132496004052 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1132496004053 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1132496004054 NAD(P) binding site [chemical binding]; other site 1132496004055 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 1132496004056 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1132496004057 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1132496004058 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1132496004059 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1132496004060 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1132496004061 N-terminal plug; other site 1132496004062 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1132496004063 ligand-binding site [chemical binding]; other site 1132496004064 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1132496004065 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1132496004066 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1132496004067 putative active site [active] 1132496004068 putative dimer interface [polypeptide binding]; other site 1132496004069 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1132496004070 serine transporter; Region: stp; TIGR00814 1132496004071 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1132496004072 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1132496004073 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1132496004074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 1132496004075 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1132496004076 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1132496004077 putative active site [active] 1132496004078 putative PHP Thumb interface [polypeptide binding]; other site 1132496004079 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1132496004080 generic binding surface II; other site 1132496004081 generic binding surface I; other site 1132496004082 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1132496004083 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1132496004084 tetramer interface [polypeptide binding]; other site 1132496004085 heme binding pocket [chemical binding]; other site 1132496004086 NADPH binding site [chemical binding]; other site 1132496004087 Predicted flavoproteins [General function prediction only]; Region: COG2081 1132496004088 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1132496004089 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1132496004090 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1132496004091 binding surface 1132496004092 TPR motif; other site 1132496004093 cytochrome c nitrite reductase, accessory protein NrfF; Region: cyt_nit_nrfF; TIGR03147 1132496004094 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 1132496004095 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1132496004096 catalytic residues [active] 1132496004097 central insert; other site 1132496004098 cytochrome c nitrate reductase biogenesis protein NrfE; Region: cyt_nit_nrfE; TIGR03145 1132496004099 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 1132496004100 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 1132496004101 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 1132496004102 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 1132496004103 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 1132496004104 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1132496004105 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1132496004106 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1132496004107 dimerization interface [polypeptide binding]; other site 1132496004108 putative ATP binding site [chemical binding]; other site 1132496004109 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1132496004110 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1132496004111 active site 1132496004112 substrate binding site [chemical binding]; other site 1132496004113 cosubstrate binding site; other site 1132496004114 catalytic site [active] 1132496004115 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1132496004116 active site 1132496004117 uracil-xanthine permease; Region: ncs2; TIGR00801 1132496004118 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1132496004119 DNA replication initiation factor; Validated; Region: PRK06893 1132496004120 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1132496004121 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1132496004122 putative metal binding site [ion binding]; other site 1132496004123 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1132496004124 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1132496004125 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1132496004126 TPR motif; other site 1132496004127 binding surface 1132496004128 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1132496004129 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1132496004130 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1132496004131 catalytic residues [active] 1132496004132 central insert; other site 1132496004133 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 1132496004134 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 1132496004135 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1132496004136 heme exporter protein CcmC; Region: ccmC; TIGR01191 1132496004137 heme exporter protein CcmB; Region: ccmB; TIGR01190 1132496004138 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1132496004139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496004140 Walker A/P-loop; other site 1132496004141 ATP binding site [chemical binding]; other site 1132496004142 Q-loop/lid; other site 1132496004143 ABC transporter signature motif; other site 1132496004144 Walker B; other site 1132496004145 D-loop; other site 1132496004146 H-loop/switch region; other site 1132496004147 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1132496004148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1132496004149 putative substrate translocation pore; other site 1132496004150 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1132496004151 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1132496004152 RNA binding surface [nucleotide binding]; other site 1132496004153 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1132496004154 active site 1132496004155 uracil binding [chemical binding]; other site 1132496004156 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1132496004157 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1132496004158 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1132496004159 putative NAD(P) binding site [chemical binding]; other site 1132496004160 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1132496004161 superoxide dismutase; Provisional; Region: PRK10925 1132496004162 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1132496004163 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1132496004164 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1132496004165 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1132496004166 active site 1132496004167 metal binding site [ion binding]; metal-binding site 1132496004168 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1132496004169 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1132496004170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1132496004171 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1132496004172 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1132496004173 dimer interface [polypeptide binding]; other site 1132496004174 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 1132496004175 active site 1132496004176 motif 2; other site 1132496004177 motif 3; other site 1132496004178 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1132496004179 anticodon binding site; other site 1132496004180 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1132496004181 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1132496004182 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1132496004183 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1132496004184 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1132496004185 non-specific DNA binding site [nucleotide binding]; other site 1132496004186 salt bridge; other site 1132496004187 sequence-specific DNA binding site [nucleotide binding]; other site 1132496004188 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1132496004189 TPR repeat; Region: TPR_11; pfam13414 1132496004190 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1132496004191 binding surface 1132496004192 TPR motif; other site 1132496004193 TPR repeat; Region: TPR_11; pfam13414 1132496004194 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1132496004195 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1132496004196 FeS/SAM binding site; other site 1132496004197 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1132496004198 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1132496004199 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1132496004200 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1132496004201 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1132496004202 MPT binding site; other site 1132496004203 trimer interface [polypeptide binding]; other site 1132496004204 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 1132496004205 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1132496004206 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1132496004207 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1132496004208 putative acyl-acceptor binding pocket; other site 1132496004209 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1132496004210 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1132496004211 transmembrane helices; other site 1132496004212 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1132496004213 TrkA-C domain; Region: TrkA_C; pfam02080 1132496004214 TrkA-C domain; Region: TrkA_C; pfam02080 1132496004215 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1132496004216 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1132496004217 RNA/DNA hybrid binding site [nucleotide binding]; other site 1132496004218 active site 1132496004219 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1132496004220 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1132496004221 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1132496004222 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1132496004223 active site 1132496004224 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1132496004225 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1132496004226 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1132496004227 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1132496004228 trimer interface [polypeptide binding]; other site 1132496004229 active site 1132496004230 UDP-GlcNAc binding site [chemical binding]; other site 1132496004231 lipid binding site [chemical binding]; lipid-binding site 1132496004232 periplasmic chaperone; Provisional; Region: PRK10780 1132496004233 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1132496004234 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1132496004235 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1132496004236 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1132496004237 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1132496004238 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1132496004239 Surface antigen; Region: Bac_surface_Ag; pfam01103 1132496004240 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1132496004241 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1132496004242 active site 1132496004243 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1132496004244 protein binding site [polypeptide binding]; other site 1132496004245 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1132496004246 protein binding site [polypeptide binding]; other site 1132496004247 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1132496004248 putative substrate binding region [chemical binding]; other site 1132496004249 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1132496004250 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1132496004251 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1132496004252 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1132496004253 putative FPP binding hydrophobic cleft; other site 1132496004254 dimer interface [polypeptide binding]; other site 1132496004255 putative IPP diphosphate binding site; other site 1132496004256 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1132496004257 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1132496004258 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1132496004259 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1132496004260 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1132496004261 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1132496004262 hinge region; other site 1132496004263 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1132496004264 putative nucleotide binding site [chemical binding]; other site 1132496004265 uridine monophosphate binding site [chemical binding]; other site 1132496004266 homohexameric interface [polypeptide binding]; other site 1132496004267 elongation factor Ts; Provisional; Region: tsf; PRK09377 1132496004268 UBA/TS-N domain; Region: UBA; pfam00627 1132496004269 Elongation factor TS; Region: EF_TS; pfam00889 1132496004270 Elongation factor TS; Region: EF_TS; pfam00889 1132496004271 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1132496004272 rRNA interaction site [nucleotide binding]; other site 1132496004273 S8 interaction site; other site 1132496004274 putative laminin-1 binding site; other site 1132496004275 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1132496004276 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1132496004277 HlyD family secretion protein; Region: HlyD_3; pfam13437 1132496004278 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1132496004279 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1132496004280 Walker A/P-loop; other site 1132496004281 ATP binding site [chemical binding]; other site 1132496004282 Q-loop/lid; other site 1132496004283 ABC transporter signature motif; other site 1132496004284 Walker B; other site 1132496004285 D-loop; other site 1132496004286 H-loop/switch region; other site 1132496004287 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496004288 Walker A/P-loop; other site 1132496004289 ATP binding site [chemical binding]; other site 1132496004290 Q-loop/lid; other site 1132496004291 ABC transporter signature motif; other site 1132496004292 Walker B; other site 1132496004293 D-loop; other site 1132496004294 H-loop/switch region; other site 1132496004295 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1132496004296 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1132496004297 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1132496004298 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1132496004299 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1132496004300 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1132496004301 periplasmic folding chaperone; Provisional; Region: PRK10788 1132496004302 SurA N-terminal domain; Region: SurA_N_3; cl07813 1132496004303 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1132496004304 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1132496004305 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1132496004306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1132496004307 Walker A motif; other site 1132496004308 ATP binding site [chemical binding]; other site 1132496004309 Walker B motif; other site 1132496004310 arginine finger; other site 1132496004311 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1132496004312 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1132496004313 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1132496004314 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1132496004315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1132496004316 Walker A motif; other site 1132496004317 ATP binding site [chemical binding]; other site 1132496004318 Walker B motif; other site 1132496004319 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1132496004320 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1132496004321 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1132496004322 oligomer interface [polypeptide binding]; other site 1132496004323 active site residues [active] 1132496004324 trigger factor; Provisional; Region: tig; PRK01490 1132496004325 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1132496004326 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1132496004327 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1132496004328 BON domain; Region: BON; pfam04972 1132496004329 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1132496004330 Predicted metalloprotease [General function prediction only]; Region: COG2321 1132496004331 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1132496004332 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 1132496004333 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 1132496004334 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1132496004335 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1132496004336 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 1132496004337 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 1132496004338 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 1132496004339 putative NAD(P) binding site [chemical binding]; other site 1132496004340 active site 1132496004341 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 1132496004342 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1132496004343 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1132496004344 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1132496004345 2-isopropylmalate synthase; Validated; Region: PRK00915 1132496004346 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1132496004347 active site 1132496004348 catalytic residues [active] 1132496004349 metal binding site [ion binding]; metal-binding site 1132496004350 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1132496004351 tartrate dehydrogenase; Region: TTC; TIGR02089 1132496004352 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1132496004353 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1132496004354 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1132496004355 substrate binding site [chemical binding]; other site 1132496004356 ligand binding site [chemical binding]; other site 1132496004357 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1132496004358 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1132496004359 substrate binding site [chemical binding]; other site 1132496004360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787 1132496004361 rod shape-determining protein MreD; Region: MreD; cl01087 1132496004362 rod shape-determining protein MreC; Region: mreC; TIGR00219 1132496004363 rod shape-determining protein MreC; Region: MreC; pfam04085 1132496004364 rod shape-determining protein MreB; Provisional; Region: PRK13927 1132496004365 MreB and similar proteins; Region: MreB_like; cd10225 1132496004366 nucleotide binding site [chemical binding]; other site 1132496004367 Mg binding site [ion binding]; other site 1132496004368 putative protofilament interaction site [polypeptide binding]; other site 1132496004369 RodZ interaction site [polypeptide binding]; other site 1132496004370 exoribonuclease R; Provisional; Region: PRK11642 1132496004371 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1132496004372 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1132496004373 RNB domain; Region: RNB; pfam00773 1132496004374 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1132496004375 RNA binding site [nucleotide binding]; other site 1132496004376 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1132496004377 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1132496004378 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1132496004379 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1132496004380 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1132496004381 E-class dimer interface [polypeptide binding]; other site 1132496004382 P-class dimer interface [polypeptide binding]; other site 1132496004383 active site 1132496004384 Cu2+ binding site [ion binding]; other site 1132496004385 Zn2+ binding site [ion binding]; other site 1132496004386 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1132496004387 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1132496004388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496004389 ABC transporter signature motif; other site 1132496004390 Walker B; other site 1132496004391 D-loop; other site 1132496004392 H-loop/switch region; other site 1132496004393 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1132496004394 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1132496004395 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1132496004396 dimer interface [polypeptide binding]; other site 1132496004397 ssDNA binding site [nucleotide binding]; other site 1132496004398 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1132496004399 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1132496004400 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1132496004401 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1132496004402 homodimer interface [polypeptide binding]; other site 1132496004403 NADP binding site [chemical binding]; other site 1132496004404 substrate binding site [chemical binding]; other site 1132496004405 integrase; Provisional; Region: int; PHA02601 1132496004406 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1132496004407 active site 1132496004408 DNA binding site [nucleotide binding] 1132496004409 Int/Topo IB signature motif; other site 1132496004410 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1132496004411 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1132496004412 Protein of unknown function (DUF551); Region: DUF551; pfam04448 1132496004413 HD domain; Region: HD_3; cl17350 1132496004414 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 1132496004415 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1132496004416 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1132496004417 dimer interface [polypeptide binding]; other site 1132496004418 ssDNA binding site [nucleotide binding]; other site 1132496004419 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1132496004420 RecT family; Region: RecT; cl04285 1132496004421 BRO family, N-terminal domain; Region: Bro-N; smart01040 1132496004422 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1132496004423 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1132496004424 non-specific DNA binding site [nucleotide binding]; other site 1132496004425 salt bridge; other site 1132496004426 sequence-specific DNA binding site [nucleotide binding]; other site 1132496004427 Predicted transcriptional regulator [Transcription]; Region: COG2932 1132496004428 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1132496004429 Catalytic site [active] 1132496004430 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1132496004431 non-specific DNA binding site [nucleotide binding]; other site 1132496004432 salt bridge; other site 1132496004433 sequence-specific DNA binding site [nucleotide binding]; other site 1132496004434 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 1132496004435 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 1132496004436 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 1132496004437 Replication protein P; Region: Phage_lambda_P; pfam06992 1132496004438 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 1132496004439 NinB protein; Region: NinB; pfam05772 1132496004440 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1132496004441 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 1132496004442 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1132496004443 catalytic residues [active] 1132496004444 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1132496004445 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1132496004446 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1132496004447 non-specific DNA binding site [nucleotide binding]; other site 1132496004448 salt bridge; other site 1132496004449 sequence-specific DNA binding site [nucleotide binding]; other site 1132496004450 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1132496004451 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 1132496004452 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 1132496004453 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 1132496004454 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1132496004455 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1132496004456 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1132496004457 oligomer interface [polypeptide binding]; other site 1132496004458 active site residues [active] 1132496004459 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 1132496004460 Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956 1132496004461 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 1132496004462 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 1132496004463 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 1132496004464 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1132496004465 ribonuclease Y; Region: RNase_Y; TIGR03319 1132496004466 Phage minor tail protein; Region: Phage_min_tail; pfam05939 1132496004467 Phage-related protein [Function unknown]; Region: gp18; COG4672 1132496004468 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1132496004469 MPN+ (JAMM) motif; other site 1132496004470 Zinc-binding site [ion binding]; other site 1132496004471 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1132496004472 NlpC/P60 family; Region: NLPC_P60; cl17555 1132496004473 Phage-related protein, tail component [Function unknown]; Region: COG4723 1132496004474 Phage-related protein, tail component [Function unknown]; Region: COG4733 1132496004475 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1132496004476 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1132496004477 Fibronectin type III protein; Region: DUF3672; pfam12421 1132496004478 Protein of unknown function, DUF417; Region: DUF417; pfam04224 1132496004479 Lipoate synthase [Coenzyme metabolism]; Region: LipA; COG0320 1132496004480 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1132496004481 FeS/SAM binding site; other site 1132496004482 lipoate-protein ligase B; Provisional; Region: PRK14342 1132496004483 hypothetical protein; Provisional; Region: PRK04998 1132496004484 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1132496004485 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1132496004486 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1132496004487 rare lipoprotein A; Region: rlpA; TIGR00413 1132496004488 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1132496004489 Sporulation related domain; Region: SPOR; pfam05036 1132496004490 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1132496004491 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1132496004492 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1132496004493 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1132496004494 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1132496004495 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1132496004496 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1132496004497 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1132496004498 ATP binding site [chemical binding]; other site 1132496004499 Mg++ binding site [ion binding]; other site 1132496004500 motif III; other site 1132496004501 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1132496004502 nucleotide binding region [chemical binding]; other site 1132496004503 ATP-binding site [chemical binding]; other site 1132496004504 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1132496004505 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1132496004506 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1132496004507 RNA binding site [nucleotide binding]; other site 1132496004508 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1132496004509 multimer interface [polypeptide binding]; other site 1132496004510 Walker A motif; other site 1132496004511 ATP binding site [chemical binding]; other site 1132496004512 Walker B motif; other site 1132496004513 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4714 1132496004514 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1132496004515 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1132496004516 acyl carrier protein; Provisional; Region: acpP; PRK00982 1132496004517 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1132496004518 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1132496004519 NAD(P) binding site [chemical binding]; other site 1132496004520 homotetramer interface [polypeptide binding]; other site 1132496004521 homodimer interface [polypeptide binding]; other site 1132496004522 active site 1132496004523 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1132496004524 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1132496004525 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1132496004526 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1132496004527 dimer interface [polypeptide binding]; other site 1132496004528 active site 1132496004529 CoA binding pocket [chemical binding]; other site 1132496004530 Fatty acid/phospholipid biosynthesis enzyme [Lipid metabolism]; Region: PlsX; COG0416 1132496004531 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1132496004532 hypothetical protein; Provisional; Region: PRK11193 1132496004533 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1132496004534 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1132496004535 peptide binding site [polypeptide binding]; other site 1132496004536 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1132496004537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496004538 dimer interface [polypeptide binding]; other site 1132496004539 conserved gate region; other site 1132496004540 putative PBP binding loops; other site 1132496004541 ABC-ATPase subunit interface; other site 1132496004542 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1132496004543 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1132496004544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496004545 dimer interface [polypeptide binding]; other site 1132496004546 conserved gate region; other site 1132496004547 ABC-ATPase subunit interface; other site 1132496004548 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1132496004549 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1132496004550 Walker A/P-loop; other site 1132496004551 ATP binding site [chemical binding]; other site 1132496004552 Q-loop/lid; other site 1132496004553 ABC transporter signature motif; other site 1132496004554 Walker B; other site 1132496004555 D-loop; other site 1132496004556 H-loop/switch region; other site 1132496004557 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1132496004558 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1132496004559 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1132496004560 Walker A/P-loop; other site 1132496004561 ATP binding site [chemical binding]; other site 1132496004562 Q-loop/lid; other site 1132496004563 ABC transporter signature motif; other site 1132496004564 Walker B; other site 1132496004565 D-loop; other site 1132496004566 H-loop/switch region; other site 1132496004567 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1132496004568 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 1132496004569 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1132496004570 active site 1132496004571 zinc binding site [ion binding]; other site 1132496004572 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1132496004573 AAA domain; Region: AAA_26; pfam13500 1132496004574 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1132496004575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496004576 S-adenosylmethionine binding site [chemical binding]; other site 1132496004577 Protein of unknown function (DUF452); Region: DUF452; pfam04301 1132496004578 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1132496004579 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1132496004580 substrate-cofactor binding pocket; other site 1132496004581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1132496004582 catalytic residue [active] 1132496004583 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173 1132496004584 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1132496004585 inhibitor-cofactor binding pocket; inhibition site 1132496004586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1132496004587 catalytic residue [active] 1132496004588 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1132496004589 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1132496004590 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1132496004591 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1132496004592 gamma-glutamyl kinase; Provisional; Region: PRK05429 1132496004593 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1132496004594 nucleotide binding site [chemical binding]; other site 1132496004595 homotetrameric interface [polypeptide binding]; other site 1132496004596 putative phosphate binding site [ion binding]; other site 1132496004597 putative allosteric binding site; other site 1132496004598 PUA domain; Region: PUA; pfam01472 1132496004599 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1132496004600 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1132496004601 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1132496004602 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1132496004603 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1132496004604 folate binding site [chemical binding]; other site 1132496004605 NADP+ binding site [chemical binding]; other site 1132496004606 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1132496004607 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1132496004608 metal-binding site [ion binding] 1132496004609 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1132496004610 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1132496004611 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1132496004612 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1132496004613 metal-binding site [ion binding] 1132496004614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1132496004615 hypothetical protein; Provisional; Region: PRK11212 1132496004616 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1132496004617 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1132496004618 dimerization interface [polypeptide binding]; other site 1132496004619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1132496004620 ATP binding site [chemical binding]; other site 1132496004621 Mg2+ binding site [ion binding]; other site 1132496004622 G-X-G motif; other site 1132496004623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1132496004624 active site 1132496004625 phosphorylation site [posttranslational modification] 1132496004626 intermolecular recognition site; other site 1132496004627 dimerization interface [polypeptide binding]; other site 1132496004628 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1132496004629 DNA binding site [nucleotide binding] 1132496004630 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1132496004631 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1132496004632 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1132496004633 hypothetical protein; Provisional; Region: PRK13689 1132496004634 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1132496004635 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1132496004636 Sulfatase; Region: Sulfatase; cl17466 1132496004637 hypothetical protein; Validated; Region: PRK06886 1132496004638 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1132496004639 active site 1132496004640 dUMP phosphatase; Provisional; Region: PRK09449 1132496004641 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1132496004642 motif II; other site 1132496004643 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1132496004644 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1132496004645 FMN binding site [chemical binding]; other site 1132496004646 active site 1132496004647 catalytic residues [active] 1132496004648 substrate binding site [chemical binding]; other site 1132496004649 Predicted membrane protein [Function unknown]; Region: COG3647 1132496004650 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1132496004651 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1132496004652 putative metal binding site [ion binding]; other site 1132496004653 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1132496004654 HSP70 interaction site [polypeptide binding]; other site 1132496004655 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1132496004656 active site 1132496004657 ribonuclease PH; Reviewed; Region: rph; PRK00173 1132496004658 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1132496004659 hexamer interface [polypeptide binding]; other site 1132496004660 active site 1132496004661 hypothetical protein; Provisional; Region: PRK11820 1132496004662 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1132496004663 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1132496004664 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1132496004665 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1132496004666 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1132496004667 CTP synthetase; Validated; Region: pyrG; PRK05380 1132496004668 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1132496004669 Catalytic site [active] 1132496004670 active site 1132496004671 UTP binding site [chemical binding]; other site 1132496004672 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1132496004673 active site 1132496004674 putative oxyanion hole; other site 1132496004675 catalytic triad [active] 1132496004676 enolase; Provisional; Region: eno; PRK00077 1132496004677 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1132496004678 dimer interface [polypeptide binding]; other site 1132496004679 metal binding site [ion binding]; metal-binding site 1132496004680 substrate binding pocket [chemical binding]; other site 1132496004681 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1132496004682 hypothetical protein; Validated; Region: PRK00228 1132496004683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1132496004684 RNA methyltransferase, RsmE family; Region: TIGR00046 1132496004685 Recombination protein O N terminal; Region: RecO_N; pfam11967 1132496004686 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 1132496004687 Recombination protein O C terminal; Region: RecO_C; pfam02565 1132496004688 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1132496004689 TRAM domain; Region: TRAM; pfam01938 1132496004690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496004691 S-adenosylmethionine binding site [chemical binding]; other site 1132496004692 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1132496004693 HD domain; Region: HD_4; pfam13328 1132496004694 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1132496004695 synthetase active site [active] 1132496004696 NTP binding site [chemical binding]; other site 1132496004697 metal binding site [ion binding]; metal-binding site 1132496004698 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1132496004699 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1132496004700 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1132496004701 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1132496004702 O-Antigen ligase; Region: Wzy_C; pfam04932 1132496004703 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1132496004704 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1132496004705 active site 1132496004706 intersubunit interface [polypeptide binding]; other site 1132496004707 zinc binding site [ion binding]; other site 1132496004708 Na+ binding site [ion binding]; other site 1132496004709 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1132496004710 Phosphoglycerate kinase; Region: PGK; pfam00162 1132496004711 substrate binding site [chemical binding]; other site 1132496004712 hinge regions; other site 1132496004713 ADP binding site [chemical binding]; other site 1132496004714 catalytic site [active] 1132496004715 Ribonuclease I [Translation, ribosomal structure and biogenesis]; Region: Rna; COG3719 1132496004716 CAS motifs; other site 1132496004717 active site 1132496004718 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1132496004719 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1132496004720 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1132496004721 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1132496004722 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1132496004723 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1132496004724 domain interface [polypeptide binding]; other site 1132496004725 putative active site [active] 1132496004726 catalytic site [active] 1132496004727 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1132496004728 domain interface [polypeptide binding]; other site 1132496004729 putative active site [active] 1132496004730 catalytic site [active] 1132496004731 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1132496004732 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1132496004733 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1132496004734 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1132496004735 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1132496004736 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1132496004737 Cysteine-rich domain; Region: CCG; pfam02754 1132496004738 Cysteine-rich domain; Region: CCG; pfam02754 1132496004739 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1132496004740 L-lactate permease; Region: Lactate_perm; cl00701 1132496004741 adenylosuccinate lyase; Provisional; Region: PRK09285 1132496004742 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1132496004743 tetramer interface [polypeptide binding]; other site 1132496004744 active site 1132496004745 Uncharacterized protein involved in purine metabolism [General function prediction only]; Region: COG2915 1132496004746 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1132496004747 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1132496004748 putative substrate binding site [chemical binding]; other site 1132496004749 putative ATP binding site [chemical binding]; other site 1132496004750 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1132496004751 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1132496004752 substrate binding [chemical binding]; other site 1132496004753 active site 1132496004754 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1132496004755 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 1132496004756 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1132496004757 DNA binding site [nucleotide binding] 1132496004758 domain linker motif; other site 1132496004759 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1132496004760 dimerization interface [polypeptide binding]; other site 1132496004761 ligand binding site [chemical binding]; other site 1132496004762 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1132496004763 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1132496004764 active site turn [active] 1132496004765 phosphorylation site [posttranslational modification] 1132496004766 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1132496004767 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 1132496004768 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1132496004769 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1132496004770 putative active site [active] 1132496004771 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1132496004772 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1132496004773 putative active site [active] 1132496004774 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1132496004775 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1132496004776 ATP binding site [chemical binding]; other site 1132496004777 Mg++ binding site [ion binding]; other site 1132496004778 motif III; other site 1132496004779 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1132496004780 nucleotide binding region [chemical binding]; other site 1132496004781 ATP-binding site [chemical binding]; other site 1132496004782 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1132496004783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496004784 S-adenosylmethionine binding site [chemical binding]; other site 1132496004785 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 1132496004786 ATP-dependent helicase HepA; Validated; Region: PRK04914 1132496004787 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1132496004788 ATP binding site [chemical binding]; other site 1132496004789 putative Mg++ binding site [ion binding]; other site 1132496004790 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1132496004791 nucleotide binding region [chemical binding]; other site 1132496004792 ATP-binding site [chemical binding]; other site 1132496004793 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1132496004794 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1132496004795 active site 1132496004796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 1132496004797 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 1132496004798 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1132496004799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1132496004800 FeS/SAM binding site; other site 1132496004801 HemN C-terminal domain; Region: HemN_C; pfam06969 1132496004802 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1132496004803 dimer interface [polypeptide binding]; other site 1132496004804 FMN binding site [chemical binding]; other site 1132496004805 potential frameshift: common BLAST hit: gi|15603696|ref|NP_246770.1| anhydro-N-acetylmuramic acid kinase 1132496004806 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 1132496004807 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 1132496004808 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1132496004809 MutS domain I; Region: MutS_I; pfam01624 1132496004810 MutS domain II; Region: MutS_II; pfam05188 1132496004811 MutS domain III; Region: MutS_III; pfam05192 1132496004812 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1132496004813 Walker A/P-loop; other site 1132496004814 ATP binding site [chemical binding]; other site 1132496004815 Q-loop/lid; other site 1132496004816 ABC transporter signature motif; other site 1132496004817 Walker B; other site 1132496004818 D-loop; other site 1132496004819 H-loop/switch region; other site 1132496004820 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1132496004821 metal ion-dependent adhesion site (MIDAS); other site 1132496004822 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1132496004823 metal ion-dependent adhesion site (MIDAS); other site 1132496004824 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1132496004825 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1132496004826 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1132496004827 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1132496004828 FtsX-like permease family; Region: FtsX; pfam02687 1132496004829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496004830 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1132496004831 Walker A/P-loop; other site 1132496004832 ATP binding site [chemical binding]; other site 1132496004833 Q-loop/lid; other site 1132496004834 ABC transporter signature motif; other site 1132496004835 Walker B; other site 1132496004836 D-loop; other site 1132496004837 H-loop/switch region; other site 1132496004838 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1132496004839 metal ion-dependent adhesion site (MIDAS); other site 1132496004840 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 1132496004841 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 1132496004842 recombinase A; Provisional; Region: recA; PRK09354 1132496004843 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1132496004844 hexamer interface [polypeptide binding]; other site 1132496004845 Walker A motif; other site 1132496004846 ATP binding site [chemical binding]; other site 1132496004847 Walker B motif; other site 1132496004848 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1132496004849 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 1132496004850 HemY protein N-terminus; Region: HemY_N; pfam07219 1132496004851 HemX; Region: HemX; pfam04375 1132496004852 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1132496004853 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1132496004854 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1132496004855 active site 1132496004856 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1132496004857 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1132496004858 domain interfaces; other site 1132496004859 active site 1132496004860 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 1132496004861 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1132496004862 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1132496004863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1132496004864 active site 1132496004865 phosphorylation site [posttranslational modification] 1132496004866 intermolecular recognition site; other site 1132496004867 dimerization interface [polypeptide binding]; other site 1132496004868 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1132496004869 DNA binding residues [nucleotide binding] 1132496004870 dimerization interface [polypeptide binding]; other site 1132496004871 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1132496004872 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1132496004873 Surface antigen; Region: Bac_surface_Ag; pfam01103 1132496004874 LysE type translocator; Region: LysE; cl00565 1132496004875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1132496004876 Family of unknown function (DUF490); Region: DUF490; pfam04357 1132496004877 Family of unknown function (DUF490); Region: DUF490; pfam04357 1132496004878 exopolyphosphatase; Provisional; Region: PRK10854 1132496004879 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1132496004880 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1132496004881 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1132496004882 Substrate binding site; other site 1132496004883 Mg++ binding site; other site 1132496004884 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1132496004885 active site 1132496004886 substrate binding site [chemical binding]; other site 1132496004887 CoA binding site [chemical binding]; other site 1132496004888 Putative SAM-dependent methyltransferase; Region: SAM_MT; pfam04445 1132496004889 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1132496004890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496004891 S-adenosylmethionine binding site [chemical binding]; other site 1132496004892 hypothetical protein; Provisional; Region: PRK11027 1132496004893 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1132496004894 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1132496004895 catalytic residues [active] 1132496004896 hinge region; other site 1132496004897 alpha helical domain; other site 1132496004898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3084 1132496004899 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1132496004900 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1132496004901 GTP binding site; other site 1132496004902 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1132496004903 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1132496004904 active site 1132496004905 phosphorylation site [posttranslational modification] 1132496004906 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1132496004907 dimerization domain swap beta strand [polypeptide binding]; other site 1132496004908 regulatory protein interface [polypeptide binding]; other site 1132496004909 active site 1132496004910 regulatory phosphorylation site [posttranslational modification]; other site 1132496004911 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1132496004912 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1132496004913 putative substrate binding site [chemical binding]; other site 1132496004914 putative ATP binding site [chemical binding]; other site 1132496004915 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1132496004916 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1132496004917 active site 1132496004918 P-loop; other site 1132496004919 phosphorylation site [posttranslational modification] 1132496004920 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1132496004921 active site 1132496004922 P-loop; other site 1132496004923 phosphorylation site [posttranslational modification] 1132496004924 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1132496004925 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 1132496004926 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 1132496004927 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1132496004928 molybdopterin cofactor binding site [chemical binding]; other site 1132496004929 substrate binding site [chemical binding]; other site 1132496004930 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1132496004931 molybdopterin cofactor binding site; other site 1132496004932 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 1132496004933 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1132496004934 Periplasmic nitrate reductase protein NapE; Region: NapE; cl01848 1132496004935 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 1132496004936 Uncharacterized conserved protein [Function unknown]; Region: COG2938 1132496004937 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1132496004938 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1132496004939 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1132496004940 DNA binding residues [nucleotide binding] 1132496004941 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 1132496004942 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1132496004943 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1132496004944 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1132496004945 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1132496004946 Positive regulator of sigma E activity [Signal transduction mechanisms]; Region: RseC; COG3086 1132496004947 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1132496004948 Walker A motif; other site 1132496004949 putative transporter; Provisional; Region: PRK10504 1132496004950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1132496004951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1132496004952 selenocysteine synthase; Provisional; Region: PRK04311 1132496004953 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1132496004954 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1132496004955 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1132496004956 catalytic residue [active] 1132496004957 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1132496004958 active site 1132496004959 tetramer interface [polypeptide binding]; other site 1132496004960 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1132496004961 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1132496004962 G1 box; other site 1132496004963 putative GEF interaction site [polypeptide binding]; other site 1132496004964 GTP/Mg2+ binding site [chemical binding]; other site 1132496004965 Switch I region; other site 1132496004966 G2 box; other site 1132496004967 G3 box; other site 1132496004968 Switch II region; other site 1132496004969 G4 box; other site 1132496004970 G5 box; other site 1132496004971 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1132496004972 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1132496004973 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1132496004974 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cl02442 1132496004975 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1132496004976 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1132496004977 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1132496004978 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 1132496004979 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1132496004980 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1132496004981 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1132496004982 MgtC family; Region: MgtC; pfam02308 1132496004983 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1132496004984 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1132496004985 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1132496004986 active site turn [active] 1132496004987 phosphorylation site [posttranslational modification] 1132496004988 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1132496004989 UbiA prenyltransferase family; Region: UbiA; pfam01040 1132496004990 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 1132496004991 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1132496004992 DNA methylase; Region: N6_N4_Mtase; pfam01555 1132496004993 DNA methylase; Region: N6_N4_Mtase; cl17433 1132496004994 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 1132496004995 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1132496004996 HslU subunit interaction site [polypeptide binding]; other site 1132496004997 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1132496004998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1132496004999 Walker A motif; other site 1132496005000 ATP binding site [chemical binding]; other site 1132496005001 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1132496005002 Walker B motif; other site 1132496005003 arginine finger; other site 1132496005004 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1132496005005 pantothenate kinase; Provisional; Region: PRK05439 1132496005006 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1132496005007 ATP-binding site [chemical binding]; other site 1132496005008 CoA-binding site [chemical binding]; other site 1132496005009 Mg2+-binding site [ion binding]; other site 1132496005010 elongation factor Tu; Reviewed; Region: PRK00049 1132496005011 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1132496005012 G1 box; other site 1132496005013 GEF interaction site [polypeptide binding]; other site 1132496005014 GTP/Mg2+ binding site [chemical binding]; other site 1132496005015 Switch I region; other site 1132496005016 G2 box; other site 1132496005017 G3 box; other site 1132496005018 Switch II region; other site 1132496005019 G4 box; other site 1132496005020 G5 box; other site 1132496005021 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1132496005022 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1132496005023 Antibiotic Binding Site [chemical binding]; other site 1132496005024 Predicted peptidase [General function prediction only]; Region: COG4099 1132496005025 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1132496005026 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1132496005027 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 1132496005028 putative NAD(P) binding site [chemical binding]; other site 1132496005029 active site 1132496005030 putative substrate binding site [chemical binding]; other site 1132496005031 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1132496005032 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1132496005033 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1132496005034 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1132496005035 putative aldolase; Validated; Region: PRK08130 1132496005036 intersubunit interface [polypeptide binding]; other site 1132496005037 active site 1132496005038 Zn2+ binding site [ion binding]; other site 1132496005039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1132496005040 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1132496005041 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1132496005042 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1132496005043 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1132496005044 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1132496005045 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1132496005046 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1132496005047 metal binding site [ion binding]; metal-binding site 1132496005048 dimer interface [polypeptide binding]; other site 1132496005049 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1132496005050 active site 1132496005051 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1132496005052 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1132496005053 dimer interface [polypeptide binding]; other site 1132496005054 motif 1; other site 1132496005055 active site 1132496005056 motif 2; other site 1132496005057 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1132496005058 putative deacylase active site [active] 1132496005059 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1132496005060 active site 1132496005061 motif 3; other site 1132496005062 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1132496005063 anticodon binding site; other site 1132496005064 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 1132496005065 N- and C-terminal domain interface [polypeptide binding]; other site 1132496005066 D-xylulose kinase; Region: XylB; TIGR01312 1132496005067 active site 1132496005068 MgATP binding site [chemical binding]; other site 1132496005069 catalytic site [active] 1132496005070 metal binding site [ion binding]; metal-binding site 1132496005071 xylulose binding site [chemical binding]; other site 1132496005072 putative homodimer interface [polypeptide binding]; other site 1132496005073 xylose isomerase; Provisional; Region: PRK05474 1132496005074 xylose isomerase; Region: xylose_isom_A; TIGR02630 1132496005075 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1132496005076 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1132496005077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1132496005078 homodimer interface [polypeptide binding]; other site 1132496005079 catalytic residue [active] 1132496005080 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1132496005081 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 1132496005082 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1132496005083 putative ligand binding site [chemical binding]; other site 1132496005084 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1132496005085 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1132496005086 Walker A/P-loop; other site 1132496005087 ATP binding site [chemical binding]; other site 1132496005088 Q-loop/lid; other site 1132496005089 ABC transporter signature motif; other site 1132496005090 Walker B; other site 1132496005091 D-loop; other site 1132496005092 H-loop/switch region; other site 1132496005093 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1132496005094 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1132496005095 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1132496005096 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1132496005097 TM-ABC transporter signature motif; other site 1132496005098 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1132496005099 putative dimerization interface [polypeptide binding]; other site 1132496005100 putative ligand binding site [chemical binding]; other site 1132496005101 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1132496005102 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1132496005103 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1132496005104 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 1132496005105 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1132496005106 substrate binding site [chemical binding]; other site 1132496005107 ATP binding site [chemical binding]; other site 1132496005108 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1132496005109 intersubunit interface [polypeptide binding]; other site 1132496005110 active site 1132496005111 zinc binding site [ion binding]; other site 1132496005112 Na+ binding site [ion binding]; other site 1132496005113 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1132496005114 fructokinase; Reviewed; Region: PRK09557 1132496005115 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1132496005116 nucleotide binding site [chemical binding]; other site 1132496005117 Acetokinase family; Region: Acetate_kinase; cl17229 1132496005118 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1132496005119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1132496005120 active site 1132496005121 phosphorylation site [posttranslational modification] 1132496005122 intermolecular recognition site; other site 1132496005123 dimerization interface [polypeptide binding]; other site 1132496005124 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1132496005125 DNA binding site [nucleotide binding] 1132496005126 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1132496005127 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 1132496005128 putative ligand binding site [chemical binding]; other site 1132496005129 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1132496005130 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1132496005131 TM-ABC transporter signature motif; other site 1132496005132 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1132496005133 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1132496005134 Walker A/P-loop; other site 1132496005135 ATP binding site [chemical binding]; other site 1132496005136 Q-loop/lid; other site 1132496005137 ABC transporter signature motif; other site 1132496005138 Walker B; other site 1132496005139 D-loop; other site 1132496005140 H-loop/switch region; other site 1132496005141 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1132496005142 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1132496005143 dimerization interface [polypeptide binding]; other site 1132496005144 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1132496005145 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1132496005146 dimer interface [polypeptide binding]; other site 1132496005147 phosphorylation site [posttranslational modification] 1132496005148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1132496005149 ATP binding site [chemical binding]; other site 1132496005150 Mg2+ binding site [ion binding]; other site 1132496005151 G-X-G motif; other site 1132496005152 Response regulator receiver domain; Region: Response_reg; pfam00072 1132496005153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1132496005154 active site 1132496005155 phosphorylation site [posttranslational modification] 1132496005156 intermolecular recognition site; other site 1132496005157 dimerization interface [polypeptide binding]; other site 1132496005158 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1132496005159 agmatinase; Region: agmatinase; TIGR01230 1132496005160 oligomer interface [polypeptide binding]; other site 1132496005161 putative active site [active] 1132496005162 Mn binding site [ion binding]; other site 1132496005163 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 1132496005164 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1132496005165 dimer interface [polypeptide binding]; other site 1132496005166 active site 1132496005167 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1132496005168 catalytic residues [active] 1132496005169 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1132496005170 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1132496005171 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1132496005172 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1132496005173 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1132496005174 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK01792 1132496005175 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1132496005176 Membrane fusogenic activity; Region: BMFP; cl01115 1132496005177 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1132496005178 non-specific DNA binding site [nucleotide binding]; other site 1132496005179 salt bridge; other site 1132496005180 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1132496005181 sequence-specific DNA binding site [nucleotide binding]; other site 1132496005182 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1132496005183 active site 1132496005184 (T/H)XGH motif; other site 1132496005185 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1132496005186 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1132496005187 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1132496005188 active site 1132496005189 metal binding site [ion binding]; metal-binding site 1132496005190 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 1132496005191 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1132496005192 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1132496005193 alphaNTD homodimer interface [polypeptide binding]; other site 1132496005194 alphaNTD - beta interaction site [polypeptide binding]; other site 1132496005195 alphaNTD - beta' interaction site [polypeptide binding]; other site 1132496005196 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1132496005197 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1132496005198 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1132496005199 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1132496005200 RNA binding surface [nucleotide binding]; other site 1132496005201 30S ribosomal protein S11; Validated; Region: PRK05309 1132496005202 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1132496005203 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1132496005204 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1132496005205 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1132496005206 SecY translocase; Region: SecY; pfam00344 1132496005207 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1132496005208 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1132496005209 23S rRNA binding site [nucleotide binding]; other site 1132496005210 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1132496005211 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1132496005212 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1132496005213 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1132496005214 5S rRNA interface [nucleotide binding]; other site 1132496005215 L27 interface [polypeptide binding]; other site 1132496005216 23S rRNA interface [nucleotide binding]; other site 1132496005217 L5 interface [polypeptide binding]; other site 1132496005218 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1132496005219 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1132496005220 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1132496005221 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1132496005222 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1132496005223 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1132496005224 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1132496005225 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1132496005226 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1132496005227 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1132496005228 RNA binding site [nucleotide binding]; other site 1132496005229 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1132496005230 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1132496005231 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1132496005232 23S rRNA interface [nucleotide binding]; other site 1132496005233 putative translocon interaction site; other site 1132496005234 signal recognition particle (SRP54) interaction site; other site 1132496005235 L23 interface [polypeptide binding]; other site 1132496005236 trigger factor interaction site; other site 1132496005237 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1132496005238 23S rRNA interface [nucleotide binding]; other site 1132496005239 5S rRNA interface [nucleotide binding]; other site 1132496005240 putative antibiotic binding site [chemical binding]; other site 1132496005241 L25 interface [polypeptide binding]; other site 1132496005242 L27 interface [polypeptide binding]; other site 1132496005243 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1132496005244 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1132496005245 G-X-X-G motif; other site 1132496005246 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1132496005247 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1132496005248 protein-rRNA interface [nucleotide binding]; other site 1132496005249 putative translocon binding site; other site 1132496005250 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1132496005251 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1132496005252 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1132496005253 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1132496005254 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1132496005255 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1132496005256 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1132496005257 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1132496005258 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1132496005259 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 1132496005260 putative ion selectivity filter; other site 1132496005261 putative pore gating glutamate residue; other site 1132496005262 putative H+/Cl- coupling transport residue; other site 1132496005263 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1132496005264 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1132496005265 FMN binding site [chemical binding]; other site 1132496005266 active site 1132496005267 catalytic residues [active] 1132496005268 substrate binding site [chemical binding]; other site 1132496005269 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 1132496005270 aromatic amino acid transport protein; Region: araaP; TIGR00837 1132496005271 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 1132496005272 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1132496005273 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1132496005274 catalytic residue [active] 1132496005275 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 1132496005276 oxaloacetate decarboxylase; Provisional; Region: PRK14040 1132496005277 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1132496005278 active site 1132496005279 catalytic residues [active] 1132496005280 metal binding site [ion binding]; metal-binding site 1132496005281 homodimer binding site [polypeptide binding]; other site 1132496005282 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1132496005283 carboxyltransferase (CT) interaction site; other site 1132496005284 biotinylation site [posttranslational modification]; other site 1132496005285 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 1132496005286 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1132496005287 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1132496005288 active site 1132496005289 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1132496005290 substrate binding site [chemical binding]; other site 1132496005291 catalytic residues [active] 1132496005292 dimer interface [polypeptide binding]; other site 1132496005293 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 1132496005294 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1132496005295 putative iron binding site [ion binding]; other site 1132496005296 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1132496005297 dimerization interface [polypeptide binding]; other site 1132496005298 substrate binding site [chemical binding]; other site 1132496005299 active site 1132496005300 calcium binding site [ion binding]; other site 1132496005301 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1132496005302 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1132496005303 ATP binding site [chemical binding]; other site 1132496005304 putative Mg++ binding site [ion binding]; other site 1132496005305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1132496005306 nucleotide binding region [chemical binding]; other site 1132496005307 ATP-binding site [chemical binding]; other site 1132496005308 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1132496005309 HRDC domain; Region: HRDC; pfam00570 1132496005310 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1132496005311 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1132496005312 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 1132496005313 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1132496005314 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1132496005315 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1132496005316 shikimate binding site; other site 1132496005317 NAD(P) binding site [chemical binding]; other site 1132496005318 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1132496005319 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1132496005320 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1132496005321 trimer interface [polypeptide binding]; other site 1132496005322 active site 1132496005323 substrate binding site [chemical binding]; other site 1132496005324 CoA binding site [chemical binding]; other site 1132496005325 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1132496005326 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1132496005327 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1132496005328 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1132496005329 SecA binding site; other site 1132496005330 Preprotein binding site; other site 1132496005331 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1132496005332 active site residue [active] 1132496005333 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1132496005334 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1132496005335 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1132496005336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1132496005337 Walker A motif; other site 1132496005338 ATP binding site [chemical binding]; other site 1132496005339 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1132496005340 active site residue [active] 1132496005341 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1132496005342 rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239 1132496005343 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1132496005344 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1132496005345 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1132496005346 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1132496005347 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 1132496005348 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1132496005349 Cysteine-rich domain; Region: CCG; pfam02754 1132496005350 Cysteine-rich domain; Region: CCG; pfam02754 1132496005351 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 1132496005352 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1132496005353 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 1132496005354 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1132496005355 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 1132496005356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1132496005357 putative substrate translocation pore; other site 1132496005358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1132496005359 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1132496005360 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1132496005361 active site 1132496005362 catalytic site [active] 1132496005363 metal binding site [ion binding]; metal-binding site 1132496005364 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1132496005365 amphipathic channel; other site 1132496005366 Asn-Pro-Ala signature motifs; other site 1132496005367 glycerol kinase; Provisional; Region: glpK; PRK00047 1132496005368 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1132496005369 N- and C-terminal domain interface [polypeptide binding]; other site 1132496005370 active site 1132496005371 MgATP binding site [chemical binding]; other site 1132496005372 catalytic site [active] 1132496005373 metal binding site [ion binding]; metal-binding site 1132496005374 glycerol binding site [chemical binding]; other site 1132496005375 homotetramer interface [polypeptide binding]; other site 1132496005376 homodimer interface [polypeptide binding]; other site 1132496005377 FBP binding site [chemical binding]; other site 1132496005378 protein IIAGlc interface [polypeptide binding]; other site 1132496005379 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 1132496005380 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1132496005381 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1132496005382 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1132496005383 ATP binding site [chemical binding]; other site 1132496005384 putative Mg++ binding site [ion binding]; other site 1132496005385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694 1132496005386 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1132496005387 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1132496005388 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1132496005389 Virulence protein [General function prediction only]; Region: COG3943 1132496005390 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 1132496005391 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 1132496005392 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1132496005393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496005394 S-adenosylmethionine binding site [chemical binding]; other site 1132496005395 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1132496005396 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1132496005397 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1132496005398 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1132496005399 RNA binding site [nucleotide binding]; other site 1132496005400 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1132496005401 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1132496005402 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1132496005403 Predicted esterase [General function prediction only]; Region: COG0627 1132496005404 S-formylglutathione hydrolase; Region: PLN02442 1132496005405 Predicted membrane protein [Function unknown]; Region: COG1584 1132496005406 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1132496005407 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1132496005408 putative catalytic cysteine [active] 1132496005409 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1132496005410 putative active site [active] 1132496005411 metal binding site [ion binding]; metal-binding site 1132496005412 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1132496005413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496005414 Walker A/P-loop; other site 1132496005415 ATP binding site [chemical binding]; other site 1132496005416 Q-loop/lid; other site 1132496005417 ABC transporter signature motif; other site 1132496005418 Walker B; other site 1132496005419 D-loop; other site 1132496005420 H-loop/switch region; other site 1132496005421 TOBE domain; Region: TOBE_2; pfam08402 1132496005422 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1132496005423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496005424 dimer interface [polypeptide binding]; other site 1132496005425 conserved gate region; other site 1132496005426 putative PBP binding loops; other site 1132496005427 ABC-ATPase subunit interface; other site 1132496005428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496005429 dimer interface [polypeptide binding]; other site 1132496005430 conserved gate region; other site 1132496005431 putative PBP binding loops; other site 1132496005432 ABC-ATPase subunit interface; other site 1132496005433 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1132496005434 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496005435 Walker A/P-loop; other site 1132496005436 ATP binding site [chemical binding]; other site 1132496005437 Q-loop/lid; other site 1132496005438 ABC transporter signature motif; other site 1132496005439 Walker B; other site 1132496005440 D-loop; other site 1132496005441 H-loop/switch region; other site 1132496005442 TOBE domain; Region: TOBE_2; pfam08402 1132496005443 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1132496005444 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1132496005445 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1132496005446 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1132496005447 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 1132496005448 HAMP domain; Region: HAMP; pfam00672 1132496005449 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1132496005450 dimer interface [polypeptide binding]; other site 1132496005451 phosphorylation site [posttranslational modification] 1132496005452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1132496005453 ATP binding site [chemical binding]; other site 1132496005454 Mg2+ binding site [ion binding]; other site 1132496005455 G-X-G motif; other site 1132496005456 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1132496005457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1132496005458 active site 1132496005459 phosphorylation site [posttranslational modification] 1132496005460 intermolecular recognition site; other site 1132496005461 dimerization interface [polypeptide binding]; other site 1132496005462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1132496005463 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1132496005464 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1132496005465 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1132496005466 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1132496005467 glutamine binding [chemical binding]; other site 1132496005468 catalytic triad [active] 1132496005469 para-aminobenzoate synthase component I; Validated; Region: PRK07093 1132496005470 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1132496005471 hypothetical protein; Provisional; Region: PRK07101 1132496005472 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1132496005473 substrate-cofactor binding pocket; other site 1132496005474 homodimer interface [polypeptide binding]; other site 1132496005475 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1132496005476 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1132496005477 homotrimer interaction site [polypeptide binding]; other site 1132496005478 putative active site [active] 1132496005479 NIPSNAP; Region: NIPSNAP; pfam07978 1132496005480 Site-specific recombinase [DNA replication, recombination, and repair]; Region: COG4389 1132496005481 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 1132496005482 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1132496005483 substrate binding site [chemical binding]; other site 1132496005484 Predicted transcriptional regulators [Transcription]; Region: COG1733 1132496005485 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1132496005486 Predicted flavoprotein [General function prediction only]; Region: COG0431 1132496005487 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1132496005488 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1132496005489 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1132496005490 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496005491 Walker A/P-loop; other site 1132496005492 ATP binding site [chemical binding]; other site 1132496005493 Q-loop/lid; other site 1132496005494 ABC transporter signature motif; other site 1132496005495 Walker B; other site 1132496005496 D-loop; other site 1132496005497 H-loop/switch region; other site 1132496005498 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1132496005499 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1132496005500 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496005501 Walker A/P-loop; other site 1132496005502 ATP binding site [chemical binding]; other site 1132496005503 Q-loop/lid; other site 1132496005504 ABC transporter signature motif; other site 1132496005505 Walker B; other site 1132496005506 D-loop; other site 1132496005507 H-loop/switch region; other site 1132496005508 EamA-like transporter family; Region: EamA; pfam00892 1132496005509 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1132496005510 EamA-like transporter family; Region: EamA; pfam00892 1132496005511 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1132496005512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1132496005513 ATP binding site [chemical binding]; other site 1132496005514 Mg2+ binding site [ion binding]; other site 1132496005515 G-X-G motif; other site 1132496005516 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1132496005517 anchoring element; other site 1132496005518 dimer interface [polypeptide binding]; other site 1132496005519 ATP binding site [chemical binding]; other site 1132496005520 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1132496005521 active site 1132496005522 putative metal-binding site [ion binding]; other site 1132496005523 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1132496005524 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1132496005525 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1132496005526 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 1132496005527 active site residue [active] 1132496005528 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1132496005529 dimerization interface [polypeptide binding]; other site 1132496005530 putative DNA binding site [nucleotide binding]; other site 1132496005531 putative Zn2+ binding site [ion binding]; other site 1132496005532 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1132496005533 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1132496005534 putative active site [active] 1132496005535 Protein of unknown function (DUF904); Region: DUF904; pfam06005 1132496005536 FMN-binding protein MioC; Provisional; Region: PRK09004 1132496005537 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1132496005538 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1132496005539 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1132496005540 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1132496005541 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1132496005542 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1132496005543 F0F1 ATP synthase subunit I; Validated; Region: PRK06099 1132496005544 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1132496005545 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1132496005546 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1132496005547 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1132496005548 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1132496005549 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1132496005550 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1132496005551 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1132496005552 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1132496005553 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1132496005554 beta subunit interaction interface [polypeptide binding]; other site 1132496005555 Walker A motif; other site 1132496005556 ATP binding site [chemical binding]; other site 1132496005557 Walker B motif; other site 1132496005558 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1132496005559 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1132496005560 core domain interface [polypeptide binding]; other site 1132496005561 delta subunit interface [polypeptide binding]; other site 1132496005562 epsilon subunit interface [polypeptide binding]; other site 1132496005563 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1132496005564 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1132496005565 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1132496005566 alpha subunit interaction interface [polypeptide binding]; other site 1132496005567 Walker A motif; other site 1132496005568 ATP binding site [chemical binding]; other site 1132496005569 Walker B motif; other site 1132496005570 inhibitor binding site; inhibition site 1132496005571 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1132496005572 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1132496005573 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1132496005574 gamma subunit interface [polypeptide binding]; other site 1132496005575 epsilon subunit interface [polypeptide binding]; other site 1132496005576 LBP interface [polypeptide binding]; other site 1132496005577 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1132496005578 CPxP motif; other site 1132496005579 hypothetical protein; Provisional; Region: PRK11568 1132496005580 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1132496005581 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1132496005582 Cation transport protein; Region: TrkH; cl17365 1132496005583 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1132496005584 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 1132496005585 hypothetical protein; Validated; Region: PRK05445 1132496005586 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 1132496005587 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1132496005588 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1132496005589 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1132496005590 catalytic site [active] 1132496005591 subunit interface [polypeptide binding]; other site 1132496005592 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1132496005593 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1132496005594 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1132496005595 conserved cys residue [active] 1132496005596 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1132496005597 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1132496005598 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1132496005599 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1132496005600 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1132496005601 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1132496005602 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1132496005603 IMP binding site; other site 1132496005604 dimer interface [polypeptide binding]; other site 1132496005605 interdomain contacts; other site 1132496005606 partial ornithine binding site; other site 1132496005607 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1132496005608 catalytic core [active] 1132496005609 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1132496005610 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1132496005611 Peptidase family M23; Region: Peptidase_M23; pfam01551 1132496005612 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1132496005613 NodB motif; other site 1132496005614 putative active site [active] 1132496005615 putative catalytic site [active] 1132496005616 Zn binding site [ion binding]; other site 1132496005617 Mg chelatase-related protein; Region: TIGR00368 1132496005618 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1132496005619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1132496005620 Walker A motif; other site 1132496005621 ATP binding site [chemical binding]; other site 1132496005622 Walker B motif; other site 1132496005623 arginine finger; other site 1132496005624 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1132496005625 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1132496005626 G1 box; other site 1132496005627 GTP/Mg2+ binding site [chemical binding]; other site 1132496005628 Switch I region; other site 1132496005629 G2 box; other site 1132496005630 G3 box; other site 1132496005631 Switch II region; other site 1132496005632 G4 box; other site 1132496005633 G5 box; other site 1132496005634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 1132496005635 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1132496005636 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1132496005637 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1132496005638 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1132496005639 sequence-specific DNA binding site [nucleotide binding]; other site 1132496005640 salt bridge; other site 1132496005641 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1132496005642 TPR motif; other site 1132496005643 binding surface 1132496005644 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1132496005645 Protein of unknown function (DUF560); Region: DUF560; pfam04575 1132496005646 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1132496005647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496005648 S-adenosylmethionine binding site [chemical binding]; other site 1132496005649 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1132496005650 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1132496005651 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1132496005652 P loop; other site 1132496005653 GTP binding site [chemical binding]; other site 1132496005654 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1132496005655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496005656 Walker A/P-loop; other site 1132496005657 ATP binding site [chemical binding]; other site 1132496005658 Q-loop/lid; other site 1132496005659 ABC transporter signature motif; other site 1132496005660 Walker B; other site 1132496005661 D-loop; other site 1132496005662 H-loop/switch region; other site 1132496005663 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1132496005664 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1132496005665 Flavin Reductases; Region: FlaRed; cl00801 1132496005666 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1132496005667 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1132496005668 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1132496005669 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1132496005670 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1132496005671 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1132496005672 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1132496005673 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1132496005674 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1132496005675 DctM-like transporters; Region: DctM; pfam06808 1132496005676 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1132496005677 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit; Region: HpaG-N-term; TIGR02305 1132496005678 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1132496005679 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1132496005680 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1132496005681 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1132496005682 NAD binding site [chemical binding]; other site 1132496005683 catalytic residues [active] 1132496005684 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1132496005685 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1132496005686 putative active site [active] 1132496005687 putative metal binding site [ion binding]; other site 1132496005688 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1132496005689 putative substrate binding pocket [chemical binding]; other site 1132496005690 trimer interface [polypeptide binding]; other site 1132496005691 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1132496005692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1132496005693 putative substrate translocation pore; other site 1132496005694 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 1132496005695 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Region: HpaI; TIGR02311 1132496005696 succinic semialdehyde dehydrogenase; Region: PLN02278 1132496005697 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1132496005698 tetramerization interface [polypeptide binding]; other site 1132496005699 NAD(P) binding site [chemical binding]; other site 1132496005700 catalytic residues [active] 1132496005701 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1132496005702 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1132496005703 active site 1132496005704 substrate-binding site [chemical binding]; other site 1132496005705 metal-binding site [ion binding] 1132496005706 ATP binding site [chemical binding]; other site 1132496005707 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1132496005708 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1132496005709 ADP-ribose binding site [chemical binding]; other site 1132496005710 dimer interface [polypeptide binding]; other site 1132496005711 active site 1132496005712 nudix motif; other site 1132496005713 metal binding site [ion binding]; metal-binding site 1132496005714 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1132496005715 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1132496005716 motif II; other site 1132496005717 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1132496005718 RNA binding surface [nucleotide binding]; other site 1132496005719 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1132496005720 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1132496005721 dimerization interface [polypeptide binding]; other site 1132496005722 domain crossover interface; other site 1132496005723 redox-dependent activation switch; other site 1132496005724 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1132496005725 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1132496005726 active site 1132496005727 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1132496005728 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1132496005729 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1132496005730 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1132496005731 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1132496005732 putative active site [active] 1132496005733 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1132496005734 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1132496005735 putative C-terminal domain interface [polypeptide binding]; other site 1132496005736 putative GSH binding site (G-site) [chemical binding]; other site 1132496005737 putative dimer interface [polypeptide binding]; other site 1132496005738 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1132496005739 putative N-terminal domain interface [polypeptide binding]; other site 1132496005740 putative dimer interface [polypeptide binding]; other site 1132496005741 putative substrate binding pocket (H-site) [chemical binding]; other site 1132496005742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1132496005743 Coenzyme A binding pocket [chemical binding]; other site 1132496005744 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 1132496005745 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1132496005746 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1132496005747 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1132496005748 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1132496005749 active site 1132496005750 motif I; other site 1132496005751 motif II; other site 1132496005752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1132496005753 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1132496005754 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1132496005755 active site 1132496005756 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1132496005757 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1132496005758 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1132496005759 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 1132496005760 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1132496005761 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1132496005762 active site 1132496005763 catalytic residues [active] 1132496005764 metal binding site [ion binding]; metal-binding site 1132496005765 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1132496005766 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1132496005767 putative active site [active] 1132496005768 substrate binding site [chemical binding]; other site 1132496005769 putative cosubstrate binding site; other site 1132496005770 catalytic site [active] 1132496005771 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1132496005772 substrate binding site [chemical binding]; other site 1132496005773 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1132496005774 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1132496005775 putative RNA binding site [nucleotide binding]; other site 1132496005776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496005777 S-adenosylmethionine binding site [chemical binding]; other site 1132496005778 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1132496005779 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1132496005780 active site 1132496005781 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1132496005782 TrkA-N domain; Region: TrkA_N; pfam02254 1132496005783 TrkA-C domain; Region: TrkA_C; pfam02080 1132496005784 TrkA-N domain; Region: TrkA_N; pfam02254 1132496005785 TrkA-C domain; Region: TrkA_C; pfam02080 1132496005786 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1132496005787 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1132496005788 RNase E inhibitor protein; Provisional; Region: PRK11191 1132496005789 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1132496005790 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3471 1132496005791 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 1132496005792 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1132496005793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 1132496005794 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1132496005795 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1132496005796 active site 1132496005797 potential frameshift: common BLAST hit: gi|378775421|ref|YP_005177664.1| autotransporter adhesin 1132496005798 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 1132496005799 YadA-like C-terminal region; Region: YadA; pfam03895 1132496005800 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1132496005801 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1132496005802 trimer interface [polypeptide binding]; other site 1132496005803 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1132496005804 trimer interface [polypeptide binding]; other site 1132496005805 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1132496005806 trimer interface [polypeptide binding]; other site 1132496005807 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1132496005808 trimer interface [polypeptide binding]; other site 1132496005809 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1132496005810 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1132496005811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1132496005812 FeS/SAM binding site; other site 1132496005813 TRAM domain; Region: TRAM; cl01282 1132496005814 uridine phosphorylase; Provisional; Region: PRK11178 1132496005815 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1132496005816 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1132496005817 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1132496005818 putative DNA binding site [nucleotide binding]; other site 1132496005819 putative Zn2+ binding site [ion binding]; other site 1132496005820 AsnC family; Region: AsnC_trans_reg; pfam01037 1132496005821 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1132496005822 dimer interface [polypeptide binding]; other site 1132496005823 active site 1132496005824 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1132496005825 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1132496005826 active site turn [active] 1132496005827 phosphorylation site [posttranslational modification] 1132496005828 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1132496005829 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1132496005830 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1132496005831 putative active site [active] 1132496005832 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1132496005833 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1132496005834 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1132496005835 putative active site [active] 1132496005836 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1132496005837 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1132496005838 substrate binding pocket [chemical binding]; other site 1132496005839 membrane-bound complex binding site; other site 1132496005840 Uncharacterized conserved protein [Function unknown]; Region: COG4729 1132496005841 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 1132496005842 DctM-like transporters; Region: DctM; pfam06808 1132496005843 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 1132496005844 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1132496005845 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496005846 Walker A/P-loop; other site 1132496005847 ATP binding site [chemical binding]; other site 1132496005848 Q-loop/lid; other site 1132496005849 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1132496005850 ABC transporter; Region: ABC_tran_2; pfam12848 1132496005851 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1132496005852 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1132496005853 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1132496005854 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1132496005855 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1132496005856 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1132496005857 DNA binding residues [nucleotide binding] 1132496005858 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1132496005859 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1132496005860 transmembrane helices; other site 1132496005861 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1132496005862 PLD-like domain; Region: PLDc_2; pfam13091 1132496005863 putative active site [active] 1132496005864 catalytic site [active] 1132496005865 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1132496005866 PLD-like domain; Region: PLDc_2; pfam13091 1132496005867 putative active site [active] 1132496005868 catalytic site [active] 1132496005869 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1132496005870 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 1132496005871 gating phenylalanine in ion channel; other site 1132496005872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4390 1132496005873 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1132496005874 FAD binding domain; Region: FAD_binding_4; pfam01565 1132496005875 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1132496005876 Peptidase E [Amino acid transport and metabolism]; Region: PepE; COG3340 1132496005877 conserved cys residue [active] 1132496005878 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 1132496005879 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1132496005880 HAMP domain; Region: HAMP; pfam00672 1132496005881 Histidine kinase; Region: HisKA_3; pfam07730 1132496005882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1132496005883 ATP binding site [chemical binding]; other site 1132496005884 Mg2+ binding site [ion binding]; other site 1132496005885 G-X-G motif; other site 1132496005886 ferredoxin-type protein NapF; Region: napF; TIGR00402 1132496005887 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1132496005888 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1132496005889 Uncharacterized protein involved in formation of periplasmic nitrate reductase [Inorganic ion transport and metabolism]; Region: NapD; COG3062 1132496005890 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1132496005891 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1132496005892 [4Fe-4S] binding site [ion binding]; other site 1132496005893 molybdopterin cofactor binding site; other site 1132496005894 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1132496005895 molybdopterin cofactor binding site; other site 1132496005896 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 1132496005897 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 1132496005898 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1132496005899 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1132496005900 Nitrate reductase cytochrome c-type subunit [Energy production and conversion]; Region: NapB; COG3043 1132496005901 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 1132496005902 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 1132496005903 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1132496005904 DNA protecting protein DprA; Region: dprA; TIGR00732 1132496005905 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1132496005906 OstA-like protein; Region: OstA; pfam03968 1132496005907 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1132496005908 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1132496005909 transaldolase-like protein; Provisional; Region: PTZ00411 1132496005910 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1132496005911 active site 1132496005912 dimer interface [polypeptide binding]; other site 1132496005913 catalytic residue [active] 1132496005914 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1132496005915 nudix motif; other site 1132496005916 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 1132496005917 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1132496005918 probable active site [active] 1132496005919 isocitrate dehydrogenase; Validated; Region: PRK07362 1132496005920 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1132496005921 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1132496005922 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1132496005923 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1132496005924 substrate binding site; other site 1132496005925 dimer interface; other site 1132496005926 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1132496005927 homotrimer interaction site [polypeptide binding]; other site 1132496005928 zinc binding site [ion binding]; other site 1132496005929 CDP-binding sites; other site 1132496005930 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1132496005931 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1132496005932 Permutation of conserved domain; other site 1132496005933 active site 1132496005934 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1132496005935 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1132496005936 Sel1-like repeats; Region: SEL1; smart00671 1132496005937 Sel1-like repeats; Region: SEL1; smart00671 1132496005938 Sel1-like repeats; Region: SEL1; smart00671 1132496005939 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1132496005940 Predicted membrane protein [Function unknown]; Region: COG1238 1132496005941 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1132496005942 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1132496005943 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1132496005944 Peptidase family M23; Region: Peptidase_M23; pfam01551 1132496005945 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1132496005946 putative active site [active] 1132496005947 dimerization interface [polypeptide binding]; other site 1132496005948 putative tRNAtyr binding site [nucleotide binding]; other site 1132496005949 hypothetical protein; Reviewed; Region: PRK01637 1132496005950 hypothetical protein; Provisional; Region: PRK01752 1132496005951 SEC-C motif; Region: SEC-C; pfam02810 1132496005952 Lysine efflux permease [General function prediction only]; Region: COG1279 1132496005953 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1132496005954 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1132496005955 substrate binding site [chemical binding]; other site 1132496005956 hexamer interface [polypeptide binding]; other site 1132496005957 metal binding site [ion binding]; metal-binding site 1132496005958 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1132496005959 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1132496005960 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1132496005961 motif II; other site 1132496005962 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1132496005963 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1132496005964 active site 1132496005965 HIGH motif; other site 1132496005966 dimer interface [polypeptide binding]; other site 1132496005967 KMSKS motif; other site 1132496005968 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1132496005969 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1132496005970 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1132496005971 threonine dehydratase; Reviewed; Region: PRK09224 1132496005972 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1132496005973 tetramer interface [polypeptide binding]; other site 1132496005974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1132496005975 catalytic residue [active] 1132496005976 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1132496005977 putative Ile/Val binding site [chemical binding]; other site 1132496005978 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1132496005979 putative Ile/Val binding site [chemical binding]; other site 1132496005980 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1132496005981 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1132496005982 aspartate racemase; Region: asp_race; TIGR00035 1132496005983 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1132496005984 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1132496005985 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1132496005986 PYR/PP interface [polypeptide binding]; other site 1132496005987 dimer interface [polypeptide binding]; other site 1132496005988 TPP binding site [chemical binding]; other site 1132496005989 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1132496005990 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1132496005991 TPP-binding site [chemical binding]; other site 1132496005992 dimer interface [polypeptide binding]; other site 1132496005993 putative hydrolase; Provisional; Region: PRK10976 1132496005994 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1132496005995 active site 1132496005996 motif I; other site 1132496005997 motif II; other site 1132496005998 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1132496005999 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1132496006000 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1132496006001 hypothetical protein; Provisional; Region: PRK11622 1132496006002 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1132496006003 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1132496006004 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1132496006005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496006006 dimer interface [polypeptide binding]; other site 1132496006007 conserved gate region; other site 1132496006008 putative PBP binding loops; other site 1132496006009 ABC-ATPase subunit interface; other site 1132496006010 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1132496006011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496006012 dimer interface [polypeptide binding]; other site 1132496006013 conserved gate region; other site 1132496006014 putative PBP binding loops; other site 1132496006015 ABC-ATPase subunit interface; other site 1132496006016 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1132496006017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496006018 Walker A/P-loop; other site 1132496006019 ATP binding site [chemical binding]; other site 1132496006020 Q-loop/lid; other site 1132496006021 ABC transporter signature motif; other site 1132496006022 Walker B; other site 1132496006023 D-loop; other site 1132496006024 H-loop/switch region; other site 1132496006025 TOBE domain; Region: TOBE_2; pfam08402 1132496006026 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1132496006027 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1132496006028 active site 1132496006029 catalytic site [active] 1132496006030 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1132496006031 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1132496006032 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1132496006033 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1132496006034 transketolase; Reviewed; Region: PRK12753 1132496006035 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1132496006036 TPP-binding site [chemical binding]; other site 1132496006037 dimer interface [polypeptide binding]; other site 1132496006038 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1132496006039 PYR/PP interface [polypeptide binding]; other site 1132496006040 dimer interface [polypeptide binding]; other site 1132496006041 TPP binding site [chemical binding]; other site 1132496006042 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1132496006043 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1132496006044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1132496006045 active site 1132496006046 motif I; other site 1132496006047 motif II; other site 1132496006048 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1132496006049 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1132496006050 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1132496006051 intersubunit interface [polypeptide binding]; other site 1132496006052 active site 1132496006053 Zn2+ binding site [ion binding]; other site 1132496006054 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1132496006055 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1132496006056 AP (apurinic/apyrimidinic) site pocket; other site 1132496006057 DNA interaction; other site 1132496006058 Metal-binding active site; metal-binding site 1132496006059 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1132496006060 active site 1132496006061 dimer interface [polypeptide binding]; other site 1132496006062 magnesium binding site [ion binding]; other site 1132496006063 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1132496006064 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1132496006065 putative N- and C-terminal domain interface [polypeptide binding]; other site 1132496006066 putative active site [active] 1132496006067 MgATP binding site [chemical binding]; other site 1132496006068 catalytic site [active] 1132496006069 metal binding site [ion binding]; metal-binding site 1132496006070 putative xylulose binding site [chemical binding]; other site 1132496006071 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1132496006072 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_6; cd06315 1132496006073 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1132496006074 putative ligand binding site [chemical binding]; other site 1132496006075 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1132496006076 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1132496006077 TM-ABC transporter signature motif; other site 1132496006078 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1132496006079 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1132496006080 Walker A/P-loop; other site 1132496006081 ATP binding site [chemical binding]; other site 1132496006082 Q-loop/lid; other site 1132496006083 ABC transporter signature motif; other site 1132496006084 Walker B; other site 1132496006085 D-loop; other site 1132496006086 H-loop/switch region; other site 1132496006087 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1132496006088 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1132496006089 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1132496006090 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1132496006091 DctM-like transporters; Region: DctM; pfam06808 1132496006092 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1132496006093 Domain of unknown function (DUF386); Region: DUF386; pfam04074 1132496006094 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 1132496006095 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1132496006096 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1132496006097 Bacterial transcriptional regulator; Region: IclR; pfam01614 1132496006098 hypothetical protein; Provisional; Region: PRK05208 1132496006099 metabolite-proton symporter; Region: 2A0106; TIGR00883 1132496006100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1132496006101 putative substrate translocation pore; other site 1132496006102 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1132496006103 active site 1132496006104 thiamine phosphate binding site [chemical binding]; other site 1132496006105 pyrophosphate binding site [ion binding]; other site 1132496006106 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1132496006107 dimer interface [polypeptide binding]; other site 1132496006108 substrate binding site [chemical binding]; other site 1132496006109 ATP binding site [chemical binding]; other site 1132496006110 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1132496006111 substrate binding site [chemical binding]; other site 1132496006112 multimerization interface [polypeptide binding]; other site 1132496006113 ATP binding site [chemical binding]; other site 1132496006114 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1132496006115 NMT1/THI5 like; Region: NMT1; pfam09084 1132496006116 Putative transcription activator [Transcription]; Region: TenA; COG0819 1132496006117 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1132496006118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496006119 dimer interface [polypeptide binding]; other site 1132496006120 conserved gate region; other site 1132496006121 putative PBP binding loops; other site 1132496006122 ABC-ATPase subunit interface; other site 1132496006123 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1132496006124 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496006125 Walker A/P-loop; other site 1132496006126 ATP binding site [chemical binding]; other site 1132496006127 Q-loop/lid; other site 1132496006128 ABC transporter signature motif; other site 1132496006129 Walker B; other site 1132496006130 D-loop; other site 1132496006131 H-loop/switch region; other site 1132496006132 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 1132496006133 RmuC family; Region: RmuC; pfam02646 1132496006134 Maf-like protein; Region: Maf; pfam02545 1132496006135 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1132496006136 active site 1132496006137 dimer interface [polypeptide binding]; other site 1132496006138 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1132496006139 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1132496006140 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1132496006141 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1132496006142 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1132496006143 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1132496006144 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1132496006145 shikimate binding site; other site 1132496006146 NAD(P) binding site [chemical binding]; other site 1132496006147 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 1132496006148 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 1132496006149 putative N- and C-terminal domain interface [polypeptide binding]; other site 1132496006150 putative active site [active] 1132496006151 putative MgATP binding site [chemical binding]; other site 1132496006152 catalytic site [active] 1132496006153 metal binding site [ion binding]; metal-binding site 1132496006154 putative carbohydrate binding site [chemical binding]; other site 1132496006155 transcriptional regulator LsrR; Provisional; Region: PRK15418 1132496006156 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1132496006157 non-specific DNA interactions [nucleotide binding]; other site 1132496006158 DNA binding site [nucleotide binding] 1132496006159 sequence specific DNA binding site [nucleotide binding]; other site 1132496006160 putative cAMP binding site [chemical binding]; other site 1132496006161 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1132496006162 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 1132496006163 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1132496006164 Walker A/P-loop; other site 1132496006165 ATP binding site [chemical binding]; other site 1132496006166 Q-loop/lid; other site 1132496006167 ABC transporter signature motif; other site 1132496006168 Walker B; other site 1132496006169 D-loop; other site 1132496006170 H-loop/switch region; other site 1132496006171 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1132496006172 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1132496006173 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1132496006174 TM-ABC transporter signature motif; other site 1132496006175 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1132496006176 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1132496006177 TM-ABC transporter signature motif; other site 1132496006178 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 1132496006179 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1132496006180 ligand binding site [chemical binding]; other site 1132496006181 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1132496006182 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1132496006183 putative active site; other site 1132496006184 catalytic residue [active] 1132496006185 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 1132496006186 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1132496006187 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1132496006188 substrate binding site [chemical binding]; other site 1132496006189 hexamer interface [polypeptide binding]; other site 1132496006190 metal binding site [ion binding]; metal-binding site 1132496006191 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1132496006192 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1132496006193 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1132496006194 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1132496006195 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1132496006196 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1132496006197 putative dimerization interface [polypeptide binding]; other site 1132496006198 ketol-acid reductoisomerase; Validated; Region: PRK05225 1132496006199 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1132496006200 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1132496006201 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1132496006202 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1132496006203 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1132496006204 homodimer interface [polypeptide binding]; other site 1132496006205 metal binding site [ion binding]; metal-binding site 1132496006206 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1132496006207 homodimer interface [polypeptide binding]; other site 1132496006208 active site 1132496006209 putative chemical substrate binding site [chemical binding]; other site 1132496006210 metal binding site [ion binding]; metal-binding site 1132496006211 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1132496006212 Ligand Binding Site [chemical binding]; other site 1132496006213 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1132496006214 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1132496006215 motif 1; other site 1132496006216 active site 1132496006217 motif 2; other site 1132496006218 motif 3; other site 1132496006219 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1132496006220 DHHA1 domain; Region: DHHA1; pfam02272 1132496006221 carbon storage regulator; Provisional; Region: PRK01712 1132496006222 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1132496006223 active site 1132496006224 tetramer interface; other site 1132496006225 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1132496006226 dimerization interface [polypeptide binding]; other site 1132496006227 DNA binding site [nucleotide binding] 1132496006228 corepressor binding sites; other site 1132496006229 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1132496006230 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1132496006231 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1132496006232 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1132496006233 Nucleoside recognition; Region: Gate; pfam07670 1132496006234 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1132496006235 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1132496006236 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1132496006237 putative active site [active] 1132496006238 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1132496006239 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1132496006240 RimM N-terminal domain; Region: RimM; pfam01782 1132496006241 PRC-barrel domain; Region: PRC; pfam05239 1132496006242 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1132496006243 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1132496006244 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 1132496006245 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1132496006246 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 1132496006247 putative metal binding site [ion binding]; other site 1132496006248 dimer interface [polypeptide binding]; other site 1132496006249 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 1132496006250 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 1132496006251 Autotransporter beta-domain; Region: Autotransporter; smart00869 1132496006252 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 1132496006253 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1132496006254 N-terminal plug; other site 1132496006255 ligand-binding site [chemical binding]; other site 1132496006256 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1132496006257 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1132496006258 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1132496006259 Walker A/P-loop; other site 1132496006260 ATP binding site [chemical binding]; other site 1132496006261 Q-loop/lid; other site 1132496006262 ABC transporter signature motif; other site 1132496006263 Walker B; other site 1132496006264 D-loop; other site 1132496006265 H-loop/switch region; other site 1132496006266 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1132496006267 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1132496006268 putative active site [active] 1132496006269 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 1132496006270 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1132496006271 active site 1132496006272 ATP binding site [chemical binding]; other site 1132496006273 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1132496006274 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1132496006275 active site 1132496006276 (T/H)XGH motif; other site 1132496006277 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1132496006278 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1132496006279 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 1132496006280 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1132496006281 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1132496006282 putative metal binding site; other site 1132496006283 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1132496006284 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 1132496006285 putative metal binding site [ion binding]; other site 1132496006286 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1132496006287 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1132496006288 ABC-ATPase subunit interface; other site 1132496006289 dimer interface [polypeptide binding]; other site 1132496006290 putative PBP binding regions; other site 1132496006291 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1132496006292 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1132496006293 Walker A/P-loop; other site 1132496006294 ATP binding site [chemical binding]; other site 1132496006295 Q-loop/lid; other site 1132496006296 ABC transporter signature motif; other site 1132496006297 Walker B; other site 1132496006298 D-loop; other site 1132496006299 H-loop/switch region; other site 1132496006300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1132496006301 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1132496006302 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1132496006303 triosephosphate isomerase; Provisional; Region: PRK14567 1132496006304 substrate binding site [chemical binding]; other site 1132496006305 dimer interface [polypeptide binding]; other site 1132496006306 catalytic triad [active] 1132496006307 hypothetical protein; Validated; Region: PRK05090 1132496006308 YGGT family; Region: YGGT; pfam02325 1132496006309 YGGT family; Region: YGGT; pfam02325 1132496006310 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1132496006311 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1132496006312 Cl binding site [ion binding]; other site 1132496006313 oligomer interface [polypeptide binding]; other site 1132496006314 hypothetical protein; Provisional; Region: PRK11702 1132496006315 Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220 1132496006316 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1132496006317 adenine DNA glycosylase; Provisional; Region: PRK10880 1132496006318 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1132496006319 minor groove reading motif; other site 1132496006320 helix-hairpin-helix signature motif; other site 1132496006321 substrate binding pocket [chemical binding]; other site 1132496006322 active site 1132496006323 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1132496006324 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1132496006325 DNA binding and oxoG recognition site [nucleotide binding] 1132496006326 oxidative damage protection protein; Provisional; Region: PRK05408 1132496006327 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1132496006328 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1132496006329 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1132496006330 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1132496006331 catalytic residue [active] 1132496006332 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1132496006333 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1132496006334 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG3056 1132496006335 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1132496006336 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1132496006337 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1132496006338 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1132496006339 ligand binding site [chemical binding]; other site 1132496006340 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1132496006341 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1132496006342 Walker A/P-loop; other site 1132496006343 ATP binding site [chemical binding]; other site 1132496006344 Q-loop/lid; other site 1132496006345 ABC transporter signature motif; other site 1132496006346 Walker B; other site 1132496006347 D-loop; other site 1132496006348 H-loop/switch region; other site 1132496006349 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1132496006350 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1132496006351 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1132496006352 TM-ABC transporter signature motif; other site 1132496006353 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 1132496006354 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1132496006355 E3 interaction surface; other site 1132496006356 lipoyl attachment site [posttranslational modification]; other site 1132496006357 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 1132496006358 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 1132496006359 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 1132496006360 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 1132496006361 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 1132496006362 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 1132496006363 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 1132496006364 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1132496006365 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 1132496006366 FAD binding pocket [chemical binding]; other site 1132496006367 FAD binding motif [chemical binding]; other site 1132496006368 phosphate binding motif [ion binding]; other site 1132496006369 beta-alpha-beta structure motif; other site 1132496006370 NAD binding pocket [chemical binding]; other site 1132496006371 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1132496006372 ApbE family; Region: ApbE; pfam02424 1132496006373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 1132496006374 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1132496006375 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1132496006376 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1132496006377 regulatory protein UhpC; Provisional; Region: PRK11663 1132496006378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1132496006379 putative substrate translocation pore; other site 1132496006380 Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851 1132496006381 MASE1; Region: MASE1; pfam05231 1132496006382 Histidine kinase; Region: HisKA_3; pfam07730 1132496006383 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1132496006384 ATP binding site [chemical binding]; other site 1132496006385 G-X-G motif; other site 1132496006386 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 1132496006387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1132496006388 active site 1132496006389 phosphorylation site [posttranslational modification] 1132496006390 intermolecular recognition site; other site 1132496006391 dimerization interface [polypeptide binding]; other site 1132496006392 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1132496006393 DNA binding residues [nucleotide binding] 1132496006394 dimerization interface [polypeptide binding]; other site 1132496006395 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1132496006396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1132496006397 putative substrate translocation pore; other site 1132496006398 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1132496006399 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1132496006400 NADP binding site [chemical binding]; other site 1132496006401 homopentamer interface [polypeptide binding]; other site 1132496006402 substrate binding site [chemical binding]; other site 1132496006403 active site 1132496006404 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1132496006405 intersubunit interface [polypeptide binding]; other site 1132496006406 active site 1132496006407 catalytic residue [active] 1132496006408 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1132496006409 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1132496006410 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1132496006411 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1132496006412 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1132496006413 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1132496006414 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1132496006415 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1132496006416 dimerization interface [polypeptide binding]; other site 1132496006417 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1132496006418 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1132496006419 catalytic triad [active] 1132496006420 dimer interface [polypeptide binding]; other site 1132496006421 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1132496006422 hypothetical protein; Provisional; Region: PRK02119 1132496006423 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1132496006424 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1132496006425 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1132496006426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1132496006427 YheO-like PAS domain; Region: PAS_6; pfam08348 1132496006428 HTH domain; Region: HTH_22; pfam13309 1132496006429 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1132496006430 sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010 1132496006431 Uncharacterized conserved protein involved in oxidation of intracellular sulfur [Inorganic ion transport and metabolism]; Region: DsrH; COG2168 1132496006432 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1132496006433 S17 interaction site [polypeptide binding]; other site 1132496006434 S8 interaction site; other site 1132496006435 16S rRNA interaction site [nucleotide binding]; other site 1132496006436 streptomycin interaction site [chemical binding]; other site 1132496006437 23S rRNA interaction site [nucleotide binding]; other site 1132496006438 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1132496006439 30S ribosomal protein S7; Validated; Region: PRK05302 1132496006440 elongation factor G; Reviewed; Region: PRK00007 1132496006441 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1132496006442 G1 box; other site 1132496006443 putative GEF interaction site [polypeptide binding]; other site 1132496006444 GTP/Mg2+ binding site [chemical binding]; other site 1132496006445 Switch I region; other site 1132496006446 G2 box; other site 1132496006447 G3 box; other site 1132496006448 Switch II region; other site 1132496006449 G4 box; other site 1132496006450 G5 box; other site 1132496006451 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1132496006452 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1132496006453 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1132496006454 elongation factor Tu; Reviewed; Region: PRK00049 1132496006455 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1132496006456 G1 box; other site 1132496006457 GEF interaction site [polypeptide binding]; other site 1132496006458 GTP/Mg2+ binding site [chemical binding]; other site 1132496006459 Switch I region; other site 1132496006460 G2 box; other site 1132496006461 G3 box; other site 1132496006462 Switch II region; other site 1132496006463 G4 box; other site 1132496006464 G5 box; other site 1132496006465 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1132496006466 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1132496006467 Antibiotic Binding Site [chemical binding]; other site 1132496006468 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1132496006469 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1132496006470 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1132496006471 putative homodimer interface [polypeptide binding]; other site 1132496006472 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1132496006473 heterodimer interface [polypeptide binding]; other site 1132496006474 homodimer interface [polypeptide binding]; other site 1132496006475 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1132496006476 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1132496006477 23S rRNA interface [nucleotide binding]; other site 1132496006478 L7/L12 interface [polypeptide binding]; other site 1132496006479 putative thiostrepton binding site; other site 1132496006480 L25 interface [polypeptide binding]; other site 1132496006481 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1132496006482 mRNA/rRNA interface [nucleotide binding]; other site 1132496006483 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1132496006484 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1132496006485 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1132496006486 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1132496006487 23S rRNA interface [nucleotide binding]; other site 1132496006488 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1132496006489 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1132496006490 core dimer interface [polypeptide binding]; other site 1132496006491 peripheral dimer interface [polypeptide binding]; other site 1132496006492 L10 interface [polypeptide binding]; other site 1132496006493 L11 interface [polypeptide binding]; other site 1132496006494 putative EF-Tu interaction site [polypeptide binding]; other site 1132496006495 putative EF-G interaction site [polypeptide binding]; other site 1132496006496 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1132496006497 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1132496006498 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1132496006499 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1132496006500 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1132496006501 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1132496006502 RPB1 interaction site [polypeptide binding]; other site 1132496006503 RPB11 interaction site [polypeptide binding]; other site 1132496006504 RPB10 interaction site [polypeptide binding]; other site 1132496006505 RPB3 interaction site [polypeptide binding]; other site 1132496006506 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1132496006507 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1132496006508 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1132496006509 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1132496006510 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1132496006511 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1132496006512 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1132496006513 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1132496006514 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1132496006515 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1132496006516 DNA binding site [nucleotide binding] 1132496006517 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1132496006518 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1132496006519 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1132496006520 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1132496006521 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1132496006522 putative NADH binding site [chemical binding]; other site 1132496006523 putative active site [active] 1132496006524 nudix motif; other site 1132496006525 putative metal binding site [ion binding]; other site 1132496006526 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1132496006527 substrate binding site [chemical binding]; other site 1132496006528 active site 1132496006529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1132496006530 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1132496006531 IHF dimer interface [polypeptide binding]; other site 1132496006532 IHF - DNA interface [nucleotide binding]; other site 1132496006533 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1132496006534 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1132496006535 glutaminase active site [active] 1132496006536 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1132496006537 dimer interface [polypeptide binding]; other site 1132496006538 active site 1132496006539 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1132496006540 dimer interface [polypeptide binding]; other site 1132496006541 active site 1132496006542 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1132496006543 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1132496006544 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1132496006545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1132496006546 dimer interface [polypeptide binding]; other site 1132496006547 conserved gate region; other site 1132496006548 ABC-ATPase subunit interface; other site 1132496006549 D-methionine ABC transporter, ATP-binding protein; Region: ABC_MetN; TIGR02314 1132496006550 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1132496006551 Walker A/P-loop; other site 1132496006552 ATP binding site [chemical binding]; other site 1132496006553 Q-loop/lid; other site 1132496006554 ABC transporter signature motif; other site 1132496006555 Walker B; other site 1132496006556 D-loop; other site 1132496006557 H-loop/switch region; other site 1132496006558 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1132496006559 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1132496006560 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1132496006561 active site 1132496006562 motif I; other site 1132496006563 motif II; other site 1132496006564 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1132496006565 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1132496006566 active site 1132496006567 DNA binding site [nucleotide binding] 1132496006568 Int/Topo IB signature motif; other site 1132496006569 Helix-turn-helix domain; Region: HTH_17; pfam12728 1132496006570 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1132496006571 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1132496006572 P63C domain; Region: P63C; pfam10546 1132496006573 Protein of unknown function (DUF551); Region: DUF551; pfam04448 1132496006574 Putative exonuclease, RdgC; Region: RdgC; pfam04381 1132496006575 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1132496006576 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1132496006577 dimer interface [polypeptide binding]; other site 1132496006578 ssDNA binding site [nucleotide binding]; other site 1132496006579 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1132496006580 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1132496006581 RecT family; Region: RecT; cl04285 1132496006582 LabA_like proteins; Region: LabA_like; cd06167 1132496006583 putative metal binding site [ion binding]; other site 1132496006584 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1132496006585 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1132496006586 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1132496006587 non-specific DNA binding site [nucleotide binding]; other site 1132496006588 salt bridge; other site 1132496006589 sequence-specific DNA binding site [nucleotide binding]; other site 1132496006590 Predicted transcriptional regulator [Transcription]; Region: COG2932 1132496006591 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1132496006592 Catalytic site [active] 1132496006593 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1132496006594 non-specific DNA binding site [nucleotide binding]; other site 1132496006595 salt bridge; other site 1132496006596 sequence-specific DNA binding site [nucleotide binding]; other site 1132496006597 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 1132496006598 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 1132496006599 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1132496006600 replicative DNA helicase; Region: DnaB; TIGR00665 1132496006601 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1132496006602 Walker A motif; other site 1132496006603 ATP binding site [chemical binding]; other site 1132496006604 Walker B motif; other site 1132496006605 DNA binding loops [nucleotide binding] 1132496006606 MT-A70; Region: MT-A70; cl01947 1132496006607 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 1132496006608 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1132496006609 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1132496006610 active site 1132496006611 metal binding site [ion binding]; metal-binding site 1132496006612 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 1132496006613 DNA Polymerase alpha zinc finger; Region: zf-DNA_Pol; pfam08996 1132496006614 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1132496006615 catalytic residues [active] 1132496006616 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 1132496006617 Homeodomain-like domain; Region: HTH_23; pfam13384 1132496006618 Phage terminase large subunit; Region: Terminase_3; cl12054 1132496006619 Terminase-like family; Region: Terminase_6; pfam03237 1132496006620 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 1132496006621 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1132496006622 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1132496006623 metal binding triad [ion binding]; metal-binding site 1132496006624 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1132496006625 HD domain; Region: HD_4; pfam13328 1132496006626 hypothetical protein; Region: PHA02451 1132496006627 phage lambda Rz-like lysis protein; Region: PHA00276 1132496006628 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 1132496006629 LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins; Region: LEM_like; cd12935 1132496006630 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 1132496006631 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 1132496006632 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 1132496006633 Phage minor tail protein; Region: Phage_min_tail; pfam05939 1132496006634 Phage-related minor tail protein [Function unknown]; Region: COG5281 1132496006635 tape measure domain; Region: tape_meas_nterm; TIGR02675 1132496006636 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 1132496006637 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 1132496006638 Phage-related protein [Function unknown]; Region: gp18; COG4672 1132496006639 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 1132496006640 MPN+ (JAMM) motif; other site 1132496006641 Zinc-binding site [ion binding]; other site 1132496006642 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1132496006643 NlpC/P60 family; Region: NLPC_P60; cl17555 1132496006644 Phage-related protein, tail component [Function unknown]; Region: COG4723 1132496006645 Phage-related protein, tail component [Function unknown]; Region: COG4733 1132496006646 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1132496006647 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1132496006648 Fibronectin type III protein; Region: DUF3672; pfam12421 1132496006649 TIR domain; Region: TIR_2; pfam13676 1132496006650 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1132496006651 DNA binding site [nucleotide binding] 1132496006652 active site 1132496006653 Int/Topo IB signature motif; other site 1132496006654 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 1132496006655 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1132496006656 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1132496006657 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1132496006658 non-specific DNA binding site [nucleotide binding]; other site 1132496006659 salt bridge; other site 1132496006660 sequence-specific DNA binding site [nucleotide binding]; other site 1132496006661 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 1132496006662 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 1132496006663 C-terminal region of Pasteurella multocida toxin residues 569-1285; Region: PMT_C; pfam11647 1132496006664 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 1132496006665 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1132496006666 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1132496006667 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1132496006668 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1132496006669 proline aminopeptidase P II; Provisional; Region: PRK10879 1132496006670 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1132496006671 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1132496006672 active site 1132496006673 hypothetical protein; Reviewed; Region: PRK01736 1132496006674 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 1132496006675 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1132496006676 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1132496006677 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 1132496006678 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1132496006679 binding surface 1132496006680 TPR motif; other site 1132496006681 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1132496006682 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1132496006683 RNA binding surface [nucleotide binding]; other site 1132496006684 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1132496006685 active site 1132496006686 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1132496006687 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1132496006688 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 1132496006689 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1132496006690 non-specific DNA binding site [nucleotide binding]; other site 1132496006691 salt bridge; other site 1132496006692 sequence-specific DNA binding site [nucleotide binding]; other site 1132496006693 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496006694 Walker A/P-loop; other site 1132496006695 ATP binding site [chemical binding]; other site 1132496006696 AAA domain; Region: AAA_21; pfam13304 1132496006697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1132496006698 Walker B; other site 1132496006699 D-loop; other site 1132496006700 H-loop/switch region; other site 1132496006701 potential frameshift: common BLAST hit: gi|378775633|ref|YP_005177876.1| protein YdeU 1132496006702 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1132496006703 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1132496006704 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1132496006705 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1132496006706 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1132496006707 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1132496006708 nucleotide binding pocket [chemical binding]; other site 1132496006709 K-X-D-G motif; other site 1132496006710 catalytic site [active] 1132496006711 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1132496006712 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1132496006713 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1132496006714 Dimer interface [polypeptide binding]; other site 1132496006715 N-acetylneuraminate lyase; Provisional; Region: PRK04147 1132496006716 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1132496006717 inhibitor site; inhibition site 1132496006718 active site 1132496006719 dimer interface [polypeptide binding]; other site 1132496006720 catalytic residue [active] 1132496006721 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1132496006722 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1132496006723 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1132496006724 putative active site [active] 1132496006725 Domain of unknown function (DUF386); Region: DUF386; pfam04074 1132496006726 N-acetylmannosamine kinase; Provisional; Region: PRK05082 1132496006727 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1132496006728 nucleotide binding site [chemical binding]; other site 1132496006729 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1132496006730 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1132496006731 putative active site cavity [active] 1132496006732 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 1132496006733 active site 1132496006734 catalytic triad [active] 1132496006735 oxyanion hole [active] 1132496006736 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1132496006737 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1132496006738 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1132496006739 DctM-like transporters; Region: DctM; pfam06808 1132496006740 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 1132496006741 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 1132496006742 Kelch motif; Region: Kelch_1; pfam01344 1132496006743 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1132496006744 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1132496006745 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1132496006746 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1132496006747 catalytic residues [active] 1132496006748 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1132496006749 Clp amino terminal domain; Region: Clp_N; pfam02861 1132496006750 Clp amino terminal domain; Region: Clp_N; pfam02861 1132496006751 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1132496006752 Walker A motif; other site 1132496006753 ATP binding site [chemical binding]; other site 1132496006754 Walker B motif; other site 1132496006755 arginine finger; other site 1132496006756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1132496006757 Walker A motif; other site 1132496006758 ATP binding site [chemical binding]; other site 1132496006759 Walker B motif; other site 1132496006760 arginine finger; other site 1132496006761 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1132496006762 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1132496006763 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1132496006764 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1132496006765 Protein of unknown function, DUF484; Region: DUF484; cl17449 1132496006766 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1132496006767 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1132496006768 active site 1132496006769 Int/Topo IB signature motif; other site 1132496006770 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1132496006771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1132496006772 motif II; other site 1132496006773 SnoaL-like domain; Region: SnoaL_2; pfam12680 1132496006774 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1132496006775 EamA-like transporter family; Region: EamA; pfam00892 1132496006776 EamA-like transporter family; Region: EamA; pfam00892 1132496006777 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1132496006778 homooctamer interface [polypeptide binding]; other site 1132496006779 active site 1132496006780 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1132496006781 cell division protein ZipA; Provisional; Region: PRK01741 1132496006782 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1132496006783 FtsZ protein binding site [polypeptide binding]; other site 1132496006784 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1132496006785 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1132496006786 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1132496006787 dimer interface [polypeptide binding]; other site 1132496006788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1132496006789 catalytic residue [active] 1132496006790 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1132496006791 dimer interface [polypeptide binding]; other site 1132496006792 allosteric magnesium binding site [ion binding]; other site 1132496006793 active site 1132496006794 aspartate-rich active site metal binding site; other site 1132496006795 Schiff base residues; other site 1132496006796 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1132496006797 sec-independent translocase; Provisional; Region: PRK01770 1132496006798 twin arginine translocase protein A; Provisional; Region: tatA; PRK01833 1132496006799 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1132496006800 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1132496006801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1132496006802 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1132496006803 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1132496006804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496006805 S-adenosylmethionine binding site [chemical binding]; other site 1132496006806 Pirin-related protein [General function prediction only]; Region: COG1741 1132496006807 Pirin; Region: Pirin; pfam02678 1132496006808 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 1132496006809 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1132496006810 Sulfatase; Region: Sulfatase; pfam00884 1132496006811 Sulfatase; Region: Sulfatase; cl17466 1132496006812 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1132496006813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1132496006814 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1132496006815 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1132496006816 membrane-bound complex binding site; other site 1132496006817 hinge residues; other site 1132496006818 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1132496006819 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1132496006820 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1132496006821 Domain of unknown function DUF21; Region: DUF21; pfam01595 1132496006822 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1132496006823 Transporter associated domain; Region: CorC_HlyC; smart01091 1132496006824 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 1132496006825 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1132496006826 active site 1132496006827 DNA polymerase III subunit delta'; Validated; Region: PRK06871 1132496006828 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1132496006829 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1132496006830 thymidylate kinase; Validated; Region: tmk; PRK00698 1132496006831 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1132496006832 TMP-binding site; other site 1132496006833 ATP-binding site [chemical binding]; other site 1132496006834 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1132496006835 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1132496006836 dimerization interface [polypeptide binding]; other site 1132496006837 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1132496006838 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1132496006839 ligand binding site [chemical binding]; other site 1132496006840 NAD binding site [chemical binding]; other site 1132496006841 tetramer interface [polypeptide binding]; other site 1132496006842 catalytic site [active] 1132496006843 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1132496006844 L-serine binding site [chemical binding]; other site 1132496006845 ACT domain interface; other site 1132496006846 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1132496006847 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1132496006848 active site 1132496006849 dimer interface [polypeptide binding]; other site 1132496006850 HemN family oxidoreductase; Provisional; Region: PRK05660 1132496006851 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1132496006852 FeS/SAM binding site; other site 1132496006853 HemN C-terminal domain; Region: HemN_C; pfam06969 1132496006854 Uncharacterized conserved protein [Function unknown]; Region: COG0393 1132496006855 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1132496006856 dimerization interface [polypeptide binding]; other site 1132496006857 active site 1132496006858 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1132496006859 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1132496006860 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1132496006861 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1132496006862 lipoprotein signal peptidase; Provisional; Region: PRK14787 1132496006863 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1132496006864 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1132496006865 active site 1132496006866 HIGH motif; other site 1132496006867 nucleotide binding site [chemical binding]; other site 1132496006868 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1132496006869 active site 1132496006870 KMSKS motif; other site 1132496006871 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1132496006872 tRNA binding surface [nucleotide binding]; other site 1132496006873 anticodon binding site; other site 1132496006874 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1132496006875 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1132496006876 active site 1132496006877 Riboflavin kinase; Region: Flavokinase; smart00904 1132496006878 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1132496006879 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1132496006880 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1132496006881 Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726 1132496006882 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1132496006883 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1132496006884 motif II; other site 1132496006885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1132496006886 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1132496006887 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1132496006888 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1132496006889 DctM-like transporters; Region: DctM; pfam06808 1132496006890 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1132496006891 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1132496006892 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1132496006893 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1132496006894 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1132496006895 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1132496006896 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1132496006897 DAK2 domain; Region: Dak2; pfam02734 1132496006898 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1132496006899 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1132496006900 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1132496006901 DNA binding residues [nucleotide binding] 1132496006902 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1132496006903 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1132496006904 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1132496006905 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1132496006906 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1132496006907 DctM-like transporters; Region: DctM; pfam06808 1132496006908 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1132496006909 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1132496006910 triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; Provisional; Region: PRK14905 1132496006911 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1132496006912 substrate binding site [chemical binding]; other site 1132496006913 dimer interface [polypeptide binding]; other site 1132496006914 catalytic triad [active] 1132496006915 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1132496006916 active site turn [active] 1132496006917 phosphorylation site [posttranslational modification] 1132496006918 transaldolase-like protein; Provisional; Region: PTZ00411 1132496006919 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1132496006920 active site 1132496006921 dimer interface [polypeptide binding]; other site 1132496006922 catalytic residue [active] 1132496006923 transketolase; Reviewed; Region: PRK12753 1132496006924 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1132496006925 TPP-binding site [chemical binding]; other site 1132496006926 dimer interface [polypeptide binding]; other site 1132496006927 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1132496006928 PYR/PP interface [polypeptide binding]; other site 1132496006929 dimer interface [polypeptide binding]; other site 1132496006930 TPP binding site [chemical binding]; other site 1132496006931 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1132496006932 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1132496006933 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1132496006934 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1132496006935 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1132496006936 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1132496006937 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1132496006938 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1132496006939 DNA binding residues [nucleotide binding] 1132496006940 DNA primase; Validated; Region: dnaG; PRK05667 1132496006941 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1132496006942 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1132496006943 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1132496006944 active site 1132496006945 metal binding site [ion binding]; metal-binding site 1132496006946 interdomain interaction site; other site 1132496006947 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1132496006948 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1132496006949 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1132496006950 UGMP family protein; Validated; Region: PRK09604 1132496006951 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1132496006952 thymidine kinase; Provisional; Region: PRK04296 1132496006953 glutathione reductase; Validated; Region: PRK06116 1132496006954 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1132496006955 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1132496006956 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1132496006957 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1132496006958 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1132496006959 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 1132496006960 predicted active site [active] 1132496006961 catalytic triad [active] 1132496006962 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1132496006963 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1132496006964 active site 1132496006965 multimer interface [polypeptide binding]; other site 1132496006966 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1132496006967 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1132496006968 DNA-binding site [nucleotide binding]; DNA binding site 1132496006969 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1132496006970 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1132496006971 homodimer interface [polypeptide binding]; other site 1132496006972 catalytic residue [active] 1132496006973 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1132496006974 Transglycosylase; Region: Transgly; pfam00912 1132496006975 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1132496006976 Competence protein A; Region: Competence_A; pfam11104 1132496006977 Pilus assembly protein, PilP; Region: PilP; pfam04351 1132496006978 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1132496006979 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1132496006980 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1132496006981 shikimate kinase; Reviewed; Region: aroK; PRK00131 1132496006982 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1132496006983 ADP binding site [chemical binding]; other site 1132496006984 magnesium binding site [ion binding]; other site 1132496006985 putative shikimate binding site; other site 1132496006986 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1132496006987 active site 1132496006988 dimer interface [polypeptide binding]; other site 1132496006989 metal binding site [ion binding]; metal-binding site 1132496006990 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1132496006991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4701 1132496006992 Protein of unknown function (DUF2547); Region: DUF2547; pfam10818 1132496006993 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1132496006994 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1132496006995 SEC-C motif; Region: SEC-C; pfam02810 1132496006996 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1132496006997 active site 1132496006998 8-oxo-dGMP binding site [chemical binding]; other site 1132496006999 nudix motif; other site 1132496007000 metal binding site [ion binding]; metal-binding site 1132496007001 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1132496007002 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1132496007003 Rare lipoprotein B [Cell envelope biogenesis, outer membrane]; Region: RlpB; COG2980 1132496007004 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1132496007005 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1132496007006 HIGH motif; other site 1132496007007 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1132496007008 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1132496007009 active site 1132496007010 KMSKS motif; other site 1132496007011 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1132496007012 tRNA binding surface [nucleotide binding]; other site 1132496007013 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1132496007014 metal-binding site [ion binding] 1132496007015 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1132496007016 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1132496007017 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1132496007018 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1132496007019 active site 1132496007020 metal binding site [ion binding]; metal-binding site 1132496007021 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1132496007022 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1132496007023 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1132496007024 SurA N-terminal domain; Region: SurA_N; pfam09312 1132496007025 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1132496007026 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1132496007027 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1132496007028 active site 1132496007029 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1132496007030 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1132496007031 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1132496007032 metal binding site [ion binding]; metal-binding site 1132496007033 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1132496007034 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1132496007035 substrate binding site [chemical binding]; other site 1132496007036 glutamase interaction surface [polypeptide binding]; other site 1132496007037 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1132496007038 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1132496007039 catalytic residues [active] 1132496007040 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1132496007041 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1132496007042 putative active site [active] 1132496007043 oxyanion strand; other site 1132496007044 catalytic triad [active] 1132496007045 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1132496007046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1132496007047 active site 1132496007048 motif I; other site 1132496007049 motif II; other site 1132496007050 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1132496007051 putative active site pocket [active] 1132496007052 4-fold oligomerization interface [polypeptide binding]; other site 1132496007053 metal binding residues [ion binding]; metal-binding site 1132496007054 3-fold/trimer interface [polypeptide binding]; other site 1132496007055 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1132496007056 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1132496007057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1132496007058 homodimer interface [polypeptide binding]; other site 1132496007059 catalytic residue [active] 1132496007060 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 1132496007061 Fic/DOC family; Region: Fic; pfam02661 1132496007062 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1132496007063 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1132496007064 NAD binding site [chemical binding]; other site 1132496007065 dimerization interface [polypeptide binding]; other site 1132496007066 product binding site; other site 1132496007067 substrate binding site [chemical binding]; other site 1132496007068 zinc binding site [ion binding]; other site 1132496007069 catalytic residues [active] 1132496007070 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1132496007071 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1132496007072 trimer interface [polypeptide binding]; other site 1132496007073 active site 1132496007074 substrate binding site [chemical binding]; other site 1132496007075 CoA binding site [chemical binding]; other site 1132496007076 Y-family of DNA polymerases; Region: PolY; cl12025 1132496007077 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1132496007078 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1132496007079 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1132496007080 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1132496007081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1132496007082 S-adenosylmethionine binding site [chemical binding]; other site 1132496007083 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1132496007084 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1132496007085 active site 1132496007086 metal binding site [ion binding]; metal-binding site 1132496007087 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1132496007088 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1132496007089 aromatic amino acid transport protein; Region: araaP; TIGR00837 1132496007090 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1132496007091 dimer interface [polypeptide binding]; other site 1132496007092 substrate binding site [chemical binding]; other site 1132496007093 metal binding sites [ion binding]; metal-binding site 1132496007094 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1132496007095 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1132496007096 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1132496007097 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1132496007098 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1132496007099 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 1132496007100 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1132496007101 Domain of unknown function DUF21; Region: DUF21; pfam01595 1132496007102 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1132496007103 Transporter associated domain; Region: CorC_HlyC; smart01091 1132496007104 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1132496007105 signal recognition particle protein; Provisional; Region: PRK10867 1132496007106 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1132496007107 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1132496007108 P loop; other site 1132496007109 GTP binding site [chemical binding]; other site 1132496007110 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1132496007111 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 1132496007112 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1132496007113 putative acyl-acceptor binding pocket; other site 1132496007114 LexA repressor; Validated; Region: PRK00215 1132496007115 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1132496007116 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1132496007117 Catalytic site [active] 1132496007118 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1132496007119 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1132496007120 dimer interface [polypeptide binding]; other site 1132496007121 ssDNA binding site [nucleotide binding]; other site 1132496007122 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1132496007123 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1132496007124 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1132496007125 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1132496007126 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1132496007127 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 1132496007128 glutamine synthetase; Provisional; Region: glnA; PRK09469 1132496007129 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1132496007130 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1132496007131 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1132496007132 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1132496007133 Switch I region; other site 1132496007134 G2 box; other site 1132496007135 putative GEF interaction site [polypeptide binding]; other site 1132496007136 G3 box; other site 1132496007137 Switch II region; other site 1132496007138 GTP/Mg2+ binding site [chemical binding]; other site 1132496007139 G4 box; other site 1132496007140 G5 box; other site 1132496007141 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1132496007142 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1132496007143 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 1132496007144 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1132496007145 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1132496007146 homodimer interaction site [polypeptide binding]; other site 1132496007147 cofactor binding site; other site 1132496007148 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1132496007149 UbiA prenyltransferase family; Region: UbiA; pfam01040 1132496007150 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1132496007151 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1132496007152 transmembrane helices; other site 1132496007153 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1132496007154 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1132496007155 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1132496007156 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1132496007157 G1 box; other site 1132496007158 GTP/Mg2+ binding site [chemical binding]; other site 1132496007159 Switch I region; other site 1132496007160 G2 box; other site 1132496007161 Switch II region; other site 1132496007162 G3 box; other site 1132496007163 G4 box; other site 1132496007164 G5 box; other site 1132496007165 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1132496007166 membrane protein insertase; Provisional; Region: PRK01318 1132496007167 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1132496007168 hypothetical protein; Validated; Region: PRK00041 1132496007169 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1132496007170 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1132496007171 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1132496007172 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1132496007173 FAD binding pocket [chemical binding]; other site 1132496007174 phosphate binding motif [ion binding]; other site 1132496007175 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1132496007176 Phosphotransferase enzyme family; Region: APH; pfam01636 1132496007177 active site 1132496007178 ATP binding site [chemical binding]; other site 1132496007179 antibiotic binding site [chemical binding]; other site 1132496007180 dihydropteroate synthase; Region: DHPS; TIGR01496 1132496007181 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1132496007182 substrate binding pocket [chemical binding]; other site 1132496007183 dimer interface [polypeptide binding]; other site 1132496007184 inhibitor binding site; inhibition site 1132496007185 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 1132496007186 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 1132496007187 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432