-- dump date   	20140619_232159
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1218933000001	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
1218933000002	Walker A motif; other site
1218933000003	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1218933000004	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1218933000005	GTP binding site; other site
1218933000006	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
1218933000007	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
1218933000008	serine/threonine protein kinase; Provisional; Region: PRK11768
1218933000009	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
1218933000010	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1218933000011	catalytic residues [active]
1218933000012	hinge region; other site
1218933000013	alpha helical domain; other site
1218933000014	DNA polymerase I; Provisional; Region: PRK05755
1218933000015	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1218933000016	active site
1218933000017	putative 5' ssDNA interaction site; other site
1218933000018	metal binding site 3; metal-binding site
1218933000019	metal binding site 1 [ion binding]; metal-binding site
1218933000020	metal binding site 2 [ion binding]; metal-binding site
1218933000021	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1218933000022	putative DNA binding site [nucleotide binding]; other site
1218933000023	putative metal binding site [ion binding]; other site
1218933000024	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
1218933000025	active site
1218933000026	catalytic site [active]
1218933000027	substrate binding site [chemical binding]; other site
1218933000028	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1218933000029	active site
1218933000030	DNA binding site [nucleotide binding]
1218933000031	catalytic site [active]
1218933000032	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1218933000033	G1 box; other site
1218933000034	GTP/Mg2+ binding site [chemical binding]; other site
1218933000035	Switch I region; other site
1218933000036	G2 box; other site
1218933000037	G3 box; other site
1218933000038	Switch II region; other site
1218933000039	G4 box; other site
1218933000040	G5 box; other site
1218933000041	Der GTPase activator; Provisional; Region: PRK05244
1218933000042	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
1218933000043	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1218933000044	FeS/SAM binding site; other site
1218933000045	HemN C-terminal domain; Region: HemN_C; pfam06969
1218933000046	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
1218933000047	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933000048	active site
1218933000049	phosphorylation site [posttranslational modification]
1218933000050	intermolecular recognition site; other site
1218933000051	dimerization interface [polypeptide binding]; other site
1218933000052	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933000053	Walker A motif; other site
1218933000054	ATP binding site [chemical binding]; other site
1218933000055	Walker B motif; other site
1218933000056	arginine finger; other site
1218933000057	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1218933000058	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
1218933000059	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1218933000060	dimer interface [polypeptide binding]; other site
1218933000061	phosphorylation site [posttranslational modification]
1218933000062	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933000063	ATP binding site [chemical binding]; other site
1218933000064	Mg2+ binding site [ion binding]; other site
1218933000065	G-X-G motif; other site
1218933000066	glutamine synthetase; Provisional; Region: glnA; PRK09469
1218933000067	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1218933000068	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1218933000069	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1218933000070	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1218933000071	G1 box; other site
1218933000072	putative GEF interaction site [polypeptide binding]; other site
1218933000073	GTP/Mg2+ binding site [chemical binding]; other site
1218933000074	Switch I region; other site
1218933000075	G2 box; other site
1218933000076	G3 box; other site
1218933000077	Switch II region; other site
1218933000078	G4 box; other site
1218933000079	G5 box; other site
1218933000080	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1218933000081	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1218933000082	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1218933000083	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1218933000084	motif II; other site
1218933000085	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1218933000086	putative active site [active]
1218933000087	dimerization interface [polypeptide binding]; other site
1218933000088	putative tRNAtyr binding site [nucleotide binding]; other site
1218933000089	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933000090	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1218933000091	Coenzyme A binding pocket [chemical binding]; other site
1218933000092	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
1218933000093	AsmA family; Region: AsmA; pfam05170
1218933000094	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1218933000095	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1218933000096	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
1218933000097	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1218933000098	Y-family of DNA polymerases; Region: PolY; cl12025
1218933000099	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1218933000100	generic binding surface II; other site
1218933000101	ssDNA binding site; other site
1218933000102	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1218933000103	ATP binding site [chemical binding]; other site
1218933000104	putative Mg++ binding site [ion binding]; other site
1218933000105	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1218933000106	nucleotide binding region [chemical binding]; other site
1218933000107	ATP-binding site [chemical binding]; other site
1218933000108	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
1218933000109	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1218933000110	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
1218933000111	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
1218933000112	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1218933000113	Zn2+ binding site [ion binding]; other site
1218933000114	Mg2+ binding site [ion binding]; other site
1218933000115	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1218933000116	synthetase active site [active]
1218933000117	NTP binding site [chemical binding]; other site
1218933000118	metal binding site [ion binding]; metal-binding site
1218933000119	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1218933000120	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1218933000121	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
1218933000122	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1218933000123	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1218933000124	catalytic site [active]
1218933000125	G-X2-G-X-G-K; other site
1218933000126	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
1218933000127	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
1218933000128	nucleotide binding pocket [chemical binding]; other site
1218933000129	K-X-D-G motif; other site
1218933000130	catalytic site [active]
1218933000131	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1218933000132	phosphoethanolamine transferase; Provisional; Region: PRK11560
1218933000133	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
1218933000134	Sulfatase; Region: Sulfatase; pfam00884
1218933000135	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
1218933000136	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
1218933000137	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1218933000138	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1218933000139	Predicted flavoproteins [General function prediction only]; Region: COG2081
1218933000140	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1218933000141	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1218933000142	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1218933000143	universal stress protein UspB; Provisional; Region: PRK04960
1218933000144	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1218933000145	Ligand Binding Site [chemical binding]; other site
1218933000146	glutamate dehydrogenase; Provisional; Region: PRK09414
1218933000147	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1218933000148	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1218933000149	NAD(P) binding site [chemical binding]; other site
1218933000150	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1218933000151	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1218933000152	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1218933000153	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1218933000154	active site
1218933000155	metal binding site [ion binding]; metal-binding site
1218933000156	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1218933000157	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933000158	S-adenosylmethionine binding site [chemical binding]; other site
1218933000159	oligopeptidase A; Provisional; Region: PRK10911
1218933000160	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1218933000161	active site
1218933000162	Zn binding site [ion binding]; other site
1218933000163	Secretin and TonB N terminus short domain; Region: STN; smart00965
1218933000164	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
1218933000165	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933000166	N-terminal plug; other site
1218933000167	ligand-binding site [chemical binding]; other site
1218933000168	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
1218933000169	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1218933000170	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1218933000171	DNA binding residues [nucleotide binding]
1218933000172	fec operon regulator FecR; Reviewed; Region: PRK09774
1218933000173	FecR protein; Region: FecR; pfam04773
1218933000174	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1218933000175	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1218933000176	Protein of unknown function (DUF2623); Region: DUF2623; pfam11115
1218933000177	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
1218933000178	Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235
1218933000179	nucleotide binding site [chemical binding]; other site
1218933000180	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1218933000181	SBD interface [polypeptide binding]; other site
1218933000182	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1218933000183	HSP70 interaction site [polypeptide binding]; other site
1218933000184	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
1218933000185	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
1218933000186	TfoX N-terminal domain; Region: TfoX_N; pfam04993
1218933000187	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
1218933000188	glutathione reductase; Validated; Region: PRK06116
1218933000189	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1218933000190	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1218933000191	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1218933000192	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
1218933000193	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
1218933000194	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1218933000195	FAD binding pocket [chemical binding]; other site
1218933000196	FAD binding motif [chemical binding]; other site
1218933000197	phosphate binding motif [ion binding]; other site
1218933000198	NAD binding pocket [chemical binding]; other site
1218933000199	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
1218933000200	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
1218933000201	dimerization domain [polypeptide binding]; other site
1218933000202	dimer interface [polypeptide binding]; other site
1218933000203	catalytic residues [active]
1218933000204	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1218933000205	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
1218933000206	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1218933000207	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1218933000208	HipA N-terminal domain; Region: Couple_hipA; pfam13657
1218933000209	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1218933000210	non-specific DNA binding site [nucleotide binding]; other site
1218933000211	salt bridge; other site
1218933000212	sequence-specific DNA binding site [nucleotide binding]; other site
1218933000213	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933000214	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933000215	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1218933000216	dimerization interface [polypeptide binding]; other site
1218933000217	Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870
1218933000218	CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029
1218933000219	alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030
1218933000220	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
1218933000221	putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027
1218933000222	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1218933000223	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1218933000224	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933000225	Walker A/P-loop; other site
1218933000226	ATP binding site [chemical binding]; other site
1218933000227	Q-loop/lid; other site
1218933000228	ABC transporter signature motif; other site
1218933000229	Walker B; other site
1218933000230	D-loop; other site
1218933000231	H-loop/switch region; other site
1218933000232	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1218933000233	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933000234	Walker A/P-loop; other site
1218933000235	ATP binding site [chemical binding]; other site
1218933000236	Q-loop/lid; other site
1218933000237	ABC transporter signature motif; other site
1218933000238	Walker B; other site
1218933000239	D-loop; other site
1218933000240	H-loop/switch region; other site
1218933000241	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1218933000242	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1218933000243	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933000244	putative PBP binding loops; other site
1218933000245	dimer interface [polypeptide binding]; other site
1218933000246	ABC-ATPase subunit interface; other site
1218933000247	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1218933000248	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933000249	dimer interface [polypeptide binding]; other site
1218933000250	conserved gate region; other site
1218933000251	putative PBP binding loops; other site
1218933000252	ABC-ATPase subunit interface; other site
1218933000253	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1218933000254	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
1218933000255	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
1218933000256	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1218933000257	dimerization interface [polypeptide binding]; other site
1218933000258	ligand binding site [chemical binding]; other site
1218933000259	NADP binding site [chemical binding]; other site
1218933000260	catalytic site [active]
1218933000261	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1218933000262	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1218933000263	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933000264	dimerization interface [polypeptide binding]; other site
1218933000265	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933000266	dimer interface [polypeptide binding]; other site
1218933000267	putative CheW interface [polypeptide binding]; other site
1218933000268	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1218933000269	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933000270	Coenzyme A binding pocket [chemical binding]; other site
1218933000271	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1218933000272	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1218933000273	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1218933000274	dimer interface [polypeptide binding]; other site
1218933000275	motif 1; other site
1218933000276	active site
1218933000277	motif 2; other site
1218933000278	motif 3; other site
1218933000279	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1218933000280	DALR anticodon binding domain; Region: DALR_1; pfam05746
1218933000281	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
1218933000282	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
1218933000283	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1218933000284	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1218933000285	active site
1218933000286	P-loop; other site
1218933000287	phosphorylation site [posttranslational modification]
1218933000288	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1218933000289	active site
1218933000290	phosphorylation site [posttranslational modification]
1218933000291	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1218933000292	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1218933000293	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1218933000294	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
1218933000295	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
1218933000296	Protein of unknown function (DUF2810); Region: DUF2810; cl08159
1218933000297	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1218933000298	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933000299	dimerization interface [polypeptide binding]; other site
1218933000300	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933000301	dimer interface [polypeptide binding]; other site
1218933000302	putative CheW interface [polypeptide binding]; other site
1218933000303	superoxide dismutase; Provisional; Region: PRK10925
1218933000304	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1218933000305	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1218933000306	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1218933000307	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
1218933000308	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1218933000309	NAD(P) binding site [chemical binding]; other site
1218933000310	catalytic residues [active]
1218933000311	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
1218933000312	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1218933000313	xylulokinase; Provisional; Region: PRK15027
1218933000314	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
1218933000315	N- and C-terminal domain interface [polypeptide binding]; other site
1218933000316	active site
1218933000317	MgATP binding site [chemical binding]; other site
1218933000318	catalytic site [active]
1218933000319	metal binding site [ion binding]; metal-binding site
1218933000320	xylulose binding site [chemical binding]; other site
1218933000321	homodimer interface [polypeptide binding]; other site
1218933000322	xylose isomerase; Provisional; Region: PRK05474
1218933000323	xylose isomerase; Region: xylose_isom_A; TIGR02630
1218933000324	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
1218933000325	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
1218933000326	putative ligand binding site [chemical binding]; other site
1218933000327	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
1218933000328	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1218933000329	Walker A/P-loop; other site
1218933000330	ATP binding site [chemical binding]; other site
1218933000331	Q-loop/lid; other site
1218933000332	ABC transporter signature motif; other site
1218933000333	Walker B; other site
1218933000334	D-loop; other site
1218933000335	H-loop/switch region; other site
1218933000336	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1218933000337	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1218933000338	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1218933000339	TM-ABC transporter signature motif; other site
1218933000340	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
1218933000341	putative dimerization interface [polypeptide binding]; other site
1218933000342	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1218933000343	putative ligand binding site [chemical binding]; other site
1218933000344	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933000345	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1218933000346	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933000347	DJ-1 family protein; Region: not_thiJ; TIGR01383
1218933000348	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
1218933000349	conserved cys residue [active]
1218933000350	argininosuccinate synthase; Validated; Region: PRK05370
1218933000351	Autoinducer synthetase; Region: Autoind_synth; pfam00765
1218933000352	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1218933000353	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1218933000354	DNA binding residues [nucleotide binding]
1218933000355	dimerization interface [polypeptide binding]; other site
1218933000356	acyl-CoA thioesterase; Provisional; Region: PRK10531
1218933000357	putative pectinesterase; Region: PLN02432; cl01911
1218933000358	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
1218933000359	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1218933000360	conserved cys residue [active]
1218933000361	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933000362	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933000363	Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521
1218933000364	active site residue [active]
1218933000365	Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882
1218933000366	GlpM protein; Region: GlpM; pfam06942
1218933000367	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204
1218933000368	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1218933000369	dimer interface [polypeptide binding]; other site
1218933000370	active site
1218933000371	CoA binding pocket [chemical binding]; other site
1218933000372	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1218933000373	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1218933000374	NAD(P) binding site [chemical binding]; other site
1218933000375	active site
1218933000376	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1218933000377	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
1218933000378	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
1218933000379	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
1218933000380	active site
1218933000381	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1218933000382	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1218933000383	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1218933000384	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1218933000385	putative di-iron ligands [ion binding]; other site
1218933000386	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1218933000387	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
1218933000388	putative di-iron ligands [ion binding]; other site
1218933000389	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
1218933000390	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
1218933000391	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
1218933000392	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1218933000393	NAD binding site [chemical binding]; other site
1218933000394	catalytic residues [active]
1218933000395	substrate binding site [chemical binding]; other site
1218933000396	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
1218933000397	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1218933000398	phosphate binding site [ion binding]; other site
1218933000399	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1218933000400	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1218933000401	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1218933000402	Protein of unknown function, DUF596; Region: DUF596; pfam04591
1218933000403	HipA N-terminal domain; Region: Couple_hipA; cl11853
1218933000404	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1218933000405	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1218933000406	hypothetical protein; Provisional; Region: PRK11820
1218933000407	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1218933000408	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1218933000409	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933000410	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933000411	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1218933000412	dimerization interface [polypeptide binding]; other site
1218933000413	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
1218933000414	catalytic nucleophile [active]
1218933000415	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663
1218933000416	SxDxEG motif; other site
1218933000417	active site
1218933000418	metal binding site [ion binding]; metal-binding site
1218933000419	homopentamer interface [polypeptide binding]; other site
1218933000420	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
1218933000421	homodimer interface [polypeptide binding]; other site
1218933000422	homotetramer interface [polypeptide binding]; other site
1218933000423	active site pocket [active]
1218933000424	cleavage site
1218933000425	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
1218933000426	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1218933000427	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933000428	dimer interface [polypeptide binding]; other site
1218933000429	conserved gate region; other site
1218933000430	putative PBP binding loops; other site
1218933000431	ABC-ATPase subunit interface; other site
1218933000432	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
1218933000433	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933000434	dimer interface [polypeptide binding]; other site
1218933000435	conserved gate region; other site
1218933000436	putative PBP binding loops; other site
1218933000437	ABC-ATPase subunit interface; other site
1218933000438	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
1218933000439	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
1218933000440	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
1218933000441	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933000442	Walker A/P-loop; other site
1218933000443	ATP binding site [chemical binding]; other site
1218933000444	Q-loop/lid; other site
1218933000445	ABC transporter signature motif; other site
1218933000446	Walker B; other site
1218933000447	D-loop; other site
1218933000448	H-loop/switch region; other site
1218933000449	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1218933000450	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933000451	Walker A/P-loop; other site
1218933000452	ATP binding site [chemical binding]; other site
1218933000453	Q-loop/lid; other site
1218933000454	ABC transporter signature motif; other site
1218933000455	Walker B; other site
1218933000456	D-loop; other site
1218933000457	H-loop/switch region; other site
1218933000458	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1218933000459	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
1218933000460	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
1218933000461	active site
1218933000462	ribonuclease PH; Reviewed; Region: rph; PRK00173
1218933000463	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1218933000464	hexamer interface [polypeptide binding]; other site
1218933000465	active site
1218933000466	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1218933000467	active site
1218933000468	division inhibitor protein; Provisional; Region: slmA; PRK09480
1218933000469	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1218933000470	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1218933000471	trimer interface [polypeptide binding]; other site
1218933000472	active site
1218933000473	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1218933000474	Flavoprotein; Region: Flavoprotein; pfam02441
1218933000475	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1218933000476	hypothetical protein; Reviewed; Region: PRK00024
1218933000477	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1218933000478	MPN+ (JAMM) motif; other site
1218933000479	Zinc-binding site [ion binding]; other site
1218933000480	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1218933000481	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1218933000482	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1218933000483	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1218933000484	DNA binding site [nucleotide binding]
1218933000485	catalytic residue [active]
1218933000486	H2TH interface [polypeptide binding]; other site
1218933000487	putative catalytic residues [active]
1218933000488	turnover-facilitating residue; other site
1218933000489	intercalation triad [nucleotide binding]; other site
1218933000490	8OG recognition residue [nucleotide binding]; other site
1218933000491	putative reading head residues; other site
1218933000492	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1218933000493	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1218933000494	putative glycosyl transferase; Provisional; Region: PRK10073
1218933000495	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1218933000496	active site
1218933000497	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1218933000498	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1218933000499	active site
1218933000500	(T/H)XGH motif; other site
1218933000501	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
1218933000502	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
1218933000503	Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534
1218933000504	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1218933000505	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1218933000506	putative metal binding site; other site
1218933000507	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1218933000508	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
1218933000509	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422
1218933000510	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1218933000511	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1218933000512	putative active site [active]
1218933000513	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1218933000514	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1218933000515	putative active site [active]
1218933000516	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1218933000517	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1218933000518	putative active site [active]
1218933000519	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
1218933000520	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
1218933000521	NADP binding site [chemical binding]; other site
1218933000522	homopentamer interface [polypeptide binding]; other site
1218933000523	substrate binding site [chemical binding]; other site
1218933000524	active site
1218933000525	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1218933000526	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1218933000527	substrate-cofactor binding pocket; other site
1218933000528	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933000529	catalytic residue [active]
1218933000530	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
1218933000531	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1218933000532	NAD(P) binding site [chemical binding]; other site
1218933000533	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
1218933000534	NodB motif; other site
1218933000535	putative active site [active]
1218933000536	putative catalytic site [active]
1218933000537	Zn binding site [ion binding]; other site
1218933000538	AmiB activator; Provisional; Region: PRK11637
1218933000539	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
1218933000540	Peptidase family M23; Region: Peptidase_M23; pfam01551
1218933000541	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1218933000542	active site residue [active]
1218933000543	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
1218933000544	SecA binding site; other site
1218933000545	Preprotein binding site; other site
1218933000546	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1218933000547	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1218933000548	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1218933000549	serine acetyltransferase; Provisional; Region: cysE; PRK11132
1218933000550	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
1218933000551	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1218933000552	trimer interface [polypeptide binding]; other site
1218933000553	active site
1218933000554	substrate binding site [chemical binding]; other site
1218933000555	CoA binding site [chemical binding]; other site
1218933000556	phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045
1218933000557	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1218933000558	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
1218933000559	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933000560	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
1218933000561	putative dimerization interface [polypeptide binding]; other site
1218933000562	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1218933000563	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1218933000564	THF binding site; other site
1218933000565	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1218933000566	substrate binding site [chemical binding]; other site
1218933000567	THF binding site; other site
1218933000568	zinc-binding site [ion binding]; other site
1218933000569	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1218933000570	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933000571	dimerization interface [polypeptide binding]; other site
1218933000572	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933000573	dimer interface [polypeptide binding]; other site
1218933000574	putative CheW interface [polypeptide binding]; other site
1218933000575	CHASE3 domain; Region: CHASE3; cl05000
1218933000576	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1218933000577	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1218933000578	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933000579	dimerization interface [polypeptide binding]; other site
1218933000580	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933000581	dimer interface [polypeptide binding]; other site
1218933000582	putative CheW interface [polypeptide binding]; other site
1218933000583	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1218933000584	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1218933000585	uridine phosphorylase; Provisional; Region: PRK11178
1218933000586	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1218933000587	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1218933000588	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1218933000589	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
1218933000590	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
1218933000591	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1218933000592	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1218933000593	active site turn [active]
1218933000594	phosphorylation site [posttranslational modification]
1218933000595	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1218933000596	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
1218933000597	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
1218933000598	putative active site pocket [active]
1218933000599	putative metal binding site [ion binding]; other site
1218933000600	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1218933000601	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933000602	DNA-binding site [nucleotide binding]; DNA binding site
1218933000603	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1218933000604	acetylornithine deacetylase; Provisional; Region: PRK05111
1218933000605	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
1218933000606	metal binding site [ion binding]; metal-binding site
1218933000607	putative dimer interface [polypeptide binding]; other site
1218933000608	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1218933000609	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1218933000610	AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249
1218933000611	nucleotide binding site [chemical binding]; other site
1218933000612	N-acetyl-L-glutamate binding site [chemical binding]; other site
1218933000613	argininosuccinate lyase; Provisional; Region: PRK04833
1218933000614	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1218933000615	active sites [active]
1218933000616	tetramer interface [polypeptide binding]; other site
1218933000617	RmuC family; Region: RmuC; pfam02646
1218933000618	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
1218933000619	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933000620	S-adenosylmethionine binding site [chemical binding]; other site
1218933000621	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
1218933000622	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1218933000623	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
1218933000624	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
1218933000625	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1218933000626	sec-independent translocase; Provisional; Region: PRK01770
1218933000627	twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921
1218933000628	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1218933000629	active site
1218933000630	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
1218933000631	dimer interface [polypeptide binding]; other site
1218933000632	allosteric magnesium binding site [ion binding]; other site
1218933000633	active site
1218933000634	aspartate-rich active site metal binding site; other site
1218933000635	Schiff base residues; other site
1218933000636	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
1218933000637	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
1218933000638	3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922
1218933000639	FMN reductase; Validated; Region: fre; PRK08051
1218933000640	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
1218933000641	FAD binding pocket [chemical binding]; other site
1218933000642	FAD binding motif [chemical binding]; other site
1218933000643	phosphate binding motif [ion binding]; other site
1218933000644	beta-alpha-beta structure motif; other site
1218933000645	NAD binding pocket [chemical binding]; other site
1218933000646	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
1218933000647	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1218933000648	dimer interface [polypeptide binding]; other site
1218933000649	active site
1218933000650	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
1218933000651	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1218933000652	substrate binding site [chemical binding]; other site
1218933000653	oxyanion hole (OAH) forming residues; other site
1218933000654	trimer interface [polypeptide binding]; other site
1218933000655	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1218933000656	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1218933000657	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1218933000658	proline dipeptidase; Provisional; Region: PRK13607
1218933000659	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
1218933000660	active site
1218933000661	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
1218933000662	hypothetical protein; Provisional; Region: PRK11568
1218933000663	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1218933000664	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1218933000665	potassium transporter; Provisional; Region: PRK10750
1218933000666	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1218933000667	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
1218933000668	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
1218933000669	FAD binding domain; Region: FAD_binding_4; pfam01565
1218933000670	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1218933000671	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1218933000672	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
1218933000673	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1218933000674	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1218933000675	pantothenate kinase; Provisional; Region: PRK05439
1218933000676	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1218933000677	ATP-binding site [chemical binding]; other site
1218933000678	CoA-binding site [chemical binding]; other site
1218933000679	Mg2+-binding site [ion binding]; other site
1218933000680	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1218933000681	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933000682	Coenzyme A binding pocket [chemical binding]; other site
1218933000683	elongation factor Tu; Reviewed; Region: PRK00049
1218933000684	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1218933000685	G1 box; other site
1218933000686	GEF interaction site [polypeptide binding]; other site
1218933000687	GTP/Mg2+ binding site [chemical binding]; other site
1218933000688	Switch I region; other site
1218933000689	G2 box; other site
1218933000690	G3 box; other site
1218933000691	Switch II region; other site
1218933000692	G4 box; other site
1218933000693	G5 box; other site
1218933000694	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1218933000695	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1218933000696	Antibiotic Binding Site [chemical binding]; other site
1218933000697	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
1218933000698	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1218933000699	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1218933000700	putative homodimer interface [polypeptide binding]; other site
1218933000701	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1218933000702	heterodimer interface [polypeptide binding]; other site
1218933000703	homodimer interface [polypeptide binding]; other site
1218933000704	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1218933000705	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1218933000706	23S rRNA interface [nucleotide binding]; other site
1218933000707	L7/L12 interface [polypeptide binding]; other site
1218933000708	putative thiostrepton binding site; other site
1218933000709	L25 interface [polypeptide binding]; other site
1218933000710	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1218933000711	mRNA/rRNA interface [nucleotide binding]; other site
1218933000712	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1218933000713	23S rRNA interface [nucleotide binding]; other site
1218933000714	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1218933000715	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1218933000716	core dimer interface [polypeptide binding]; other site
1218933000717	peripheral dimer interface [polypeptide binding]; other site
1218933000718	L10 interface [polypeptide binding]; other site
1218933000719	L11 interface [polypeptide binding]; other site
1218933000720	putative EF-Tu interaction site [polypeptide binding]; other site
1218933000721	putative EF-G interaction site [polypeptide binding]; other site
1218933000722	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1218933000723	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1218933000724	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1218933000725	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1218933000726	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
1218933000727	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1218933000728	RPB3 interaction site [polypeptide binding]; other site
1218933000729	RPB1 interaction site [polypeptide binding]; other site
1218933000730	RPB11 interaction site [polypeptide binding]; other site
1218933000731	RPB10 interaction site [polypeptide binding]; other site
1218933000732	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1218933000733	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
1218933000734	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1218933000735	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1218933000736	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1218933000737	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
1218933000738	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1218933000739	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1218933000740	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1218933000741	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1218933000742	DNA binding site [nucleotide binding]
1218933000743	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1218933000744	shikimate transporter; Provisional; Region: PRK09952
1218933000745	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933000746	putative substrate translocation pore; other site
1218933000747	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
1218933000748	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1218933000749	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933000750	DNA-binding site [nucleotide binding]; DNA binding site
1218933000751	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1218933000752	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933000753	homodimer interface [polypeptide binding]; other site
1218933000754	catalytic residue [active]
1218933000755	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1218933000756	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1218933000757	FeS/SAM binding site; other site
1218933000758	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1218933000759	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1218933000760	ThiS interaction site; other site
1218933000761	putative active site [active]
1218933000762	tetramer interface [polypeptide binding]; other site
1218933000763	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1218933000764	thiS-thiF/thiG interaction site; other site
1218933000765	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
1218933000766	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1218933000767	ATP binding site [chemical binding]; other site
1218933000768	substrate interface [chemical binding]; other site
1218933000769	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1218933000770	thiamine phosphate binding site [chemical binding]; other site
1218933000771	active site
1218933000772	pyrophosphate binding site [ion binding]; other site
1218933000773	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1218933000774	ThiC-associated domain; Region: ThiC-associated; pfam13667
1218933000775	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
1218933000776	anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718
1218933000777	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
1218933000778	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
1218933000779	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
1218933000780	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1218933000781	putative NADH binding site [chemical binding]; other site
1218933000782	putative active site [active]
1218933000783	nudix motif; other site
1218933000784	putative metal binding site [ion binding]; other site
1218933000785	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1218933000786	substrate binding site [chemical binding]; other site
1218933000787	active site
1218933000788	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
1218933000789	Active_site [active]
1218933000790	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
1218933000791	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1218933000792	IHF dimer interface [polypeptide binding]; other site
1218933000793	IHF - DNA interface [nucleotide binding]; other site
1218933000794	Protein of unknown function (DUF1481); Region: DUF1481; pfam07356
1218933000795	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1218933000796	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1218933000797	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1218933000798	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1218933000799	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1218933000800	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1218933000801	purine monophosphate binding site [chemical binding]; other site
1218933000802	dimer interface [polypeptide binding]; other site
1218933000803	putative catalytic residues [active]
1218933000804	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1218933000805	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1218933000806	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1218933000807	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1218933000808	Walker A/P-loop; other site
1218933000809	ATP binding site [chemical binding]; other site
1218933000810	Q-loop/lid; other site
1218933000811	ABC transporter signature motif; other site
1218933000812	Walker B; other site
1218933000813	D-loop; other site
1218933000814	H-loop/switch region; other site
1218933000815	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933000816	dimer interface [polypeptide binding]; other site
1218933000817	conserved gate region; other site
1218933000818	putative PBP binding loops; other site
1218933000819	ABC-ATPase subunit interface; other site
1218933000820	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
1218933000821	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933000822	conserved gate region; other site
1218933000823	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933000824	dimer interface [polypeptide binding]; other site
1218933000825	ABC-ATPase subunit interface; other site
1218933000826	putative PBP binding loops; other site
1218933000827	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1218933000828	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1218933000829	substrate binding pocket [chemical binding]; other site
1218933000830	membrane-bound complex binding site; other site
1218933000831	hinge residues; other site
1218933000832	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1218933000833	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933000834	dimer interface [polypeptide binding]; other site
1218933000835	conserved gate region; other site
1218933000836	putative PBP binding loops; other site
1218933000837	ABC-ATPase subunit interface; other site
1218933000838	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1218933000839	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1218933000840	substrate binding pocket [chemical binding]; other site
1218933000841	membrane-bound complex binding site; other site
1218933000842	hinge residues; other site
1218933000843	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1218933000844	putative catalytic site [active]
1218933000845	putative metal binding site [ion binding]; other site
1218933000846	putative phosphate binding site [ion binding]; other site
1218933000847	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
1218933000848	active site
1218933000849	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
1218933000850	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1218933000851	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1218933000852	active site
1218933000853	ATP binding site [chemical binding]; other site
1218933000854	substrate binding site [chemical binding]; other site
1218933000855	activation loop (A-loop); other site
1218933000856	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
1218933000857	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
1218933000858	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
1218933000859	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1218933000860	FMN binding site [chemical binding]; other site
1218933000861	active site
1218933000862	catalytic residues [active]
1218933000863	substrate binding site [chemical binding]; other site
1218933000864	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
1218933000865	active site
1218933000866	zinc binding site [ion binding]; other site
1218933000867	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1218933000868	Methyltransferase domain; Region: Methyltransf_18; pfam12847
1218933000869	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
1218933000870	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1218933000871	Na binding site [ion binding]; other site
1218933000872	Protein of unknown function (DUF997); Region: DUF997; cl01614
1218933000873	molybdenum-pterin binding domain; Region: Mop; TIGR00638
1218933000874	molybdenum-pterin binding domain; Region: Mop; TIGR00638
1218933000875	2-isopropylmalate synthase; Validated; Region: PRK03739
1218933000876	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1218933000877	active site
1218933000878	catalytic residues [active]
1218933000879	metal binding site [ion binding]; metal-binding site
1218933000880	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1218933000881	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1218933000882	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1218933000883	DNA binding residues [nucleotide binding]
1218933000884	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933000885	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1218933000886	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1218933000887	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1218933000888	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1218933000889	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1218933000890	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1218933000891	carboxyltransferase (CT) interaction site; other site
1218933000892	biotinylation site [posttranslational modification]; other site
1218933000893	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1218933000894	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1218933000895	active site
1218933000896	trimer interface [polypeptide binding]; other site
1218933000897	dimer interface [polypeptide binding]; other site
1218933000898	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
1218933000899	TMAO/DMSO reductase; Reviewed; Region: PRK05363
1218933000900	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
1218933000901	Moco binding site; other site
1218933000902	metal coordination site [ion binding]; other site
1218933000903	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
1218933000904	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1218933000905	NADP binding site [chemical binding]; other site
1218933000906	dimer interface [polypeptide binding]; other site
1218933000907	regulatory protein CsrD; Provisional; Region: PRK11059
1218933000908	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1218933000909	metal binding site [ion binding]; metal-binding site
1218933000910	active site
1218933000911	I-site; other site
1218933000912	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1218933000913	rod shape-determining protein MreB; Provisional; Region: PRK13927
1218933000914	MreB and similar proteins; Region: MreB_like; cd10225
1218933000915	nucleotide binding site [chemical binding]; other site
1218933000916	Mg binding site [ion binding]; other site
1218933000917	putative protofilament interaction site [polypeptide binding]; other site
1218933000918	RodZ interaction site [polypeptide binding]; other site
1218933000919	rod shape-determining protein MreC; Region: mreC; TIGR00219
1218933000920	rod shape-determining protein MreC; Region: MreC; pfam04085
1218933000921	rod shape-determining protein MreD; Provisional; Region: PRK11060
1218933000922	Maf-like protein; Region: Maf; pfam02545
1218933000923	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1218933000924	active site
1218933000925	dimer interface [polypeptide binding]; other site
1218933000926	ribonuclease G; Provisional; Region: PRK11712
1218933000927	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1218933000928	homodimer interface [polypeptide binding]; other site
1218933000929	oligonucleotide binding site [chemical binding]; other site
1218933000930	hypothetical protein; Provisional; Region: PRK10899
1218933000931	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1218933000932	protease TldD; Provisional; Region: tldD; PRK10735
1218933000933	transcriptional regulator; Provisional; Region: PRK10632
1218933000934	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933000935	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1218933000936	putative effector binding pocket; other site
1218933000937	dimerization interface [polypeptide binding]; other site
1218933000938	efflux system membrane protein; Provisional; Region: PRK11594
1218933000939	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
1218933000940	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1218933000941	HlyD family secretion protein; Region: HlyD_3; pfam13437
1218933000942	p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631
1218933000943	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1218933000944	succinic semialdehyde dehydrogenase; Region: PLN02278
1218933000945	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1218933000946	tetramerization interface [polypeptide binding]; other site
1218933000947	NAD(P) binding site [chemical binding]; other site
1218933000948	catalytic residues [active]
1218933000949	hypothetical protein; Provisional; Region: PRK05255
1218933000950	peptidase PmbA; Provisional; Region: PRK11040
1218933000951	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
1218933000952	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1218933000953	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1218933000954	dimerization domain swap beta strand [polypeptide binding]; other site
1218933000955	regulatory protein interface [polypeptide binding]; other site
1218933000956	active site
1218933000957	regulatory phosphorylation site [posttranslational modification]; other site
1218933000958	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
1218933000959	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1218933000960	active site
1218933000961	phosphorylation site [posttranslational modification]
1218933000962	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1218933000963	30S subunit binding site; other site
1218933000964	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
1218933000965	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1218933000966	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1218933000967	lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895
1218933000968	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1218933000969	Walker A/P-loop; other site
1218933000970	ATP binding site [chemical binding]; other site
1218933000971	Q-loop/lid; other site
1218933000972	ABC transporter signature motif; other site
1218933000973	Walker B; other site
1218933000974	D-loop; other site
1218933000975	H-loop/switch region; other site
1218933000976	lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894
1218933000977	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
1218933000978	lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893
1218933000979	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
1218933000980	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
1218933000981	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
1218933000982	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
1218933000983	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1218933000984	putative active site [active]
1218933000985	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1218933000986	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
1218933000987	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1218933000988	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1218933000989	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
1218933000990	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1218933000991	Walker A/P-loop; other site
1218933000992	ATP binding site [chemical binding]; other site
1218933000993	Q-loop/lid; other site
1218933000994	ABC transporter signature motif; other site
1218933000995	Walker B; other site
1218933000996	D-loop; other site
1218933000997	H-loop/switch region; other site
1218933000998	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1218933000999	conserved hypothetical integral membrane protein; Region: TIGR00056
1218933001000	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1218933001001	mce related protein; Region: MCE; pfam02470
1218933001002	ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117
1218933001003	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1218933001004	anti sigma factor interaction site; other site
1218933001005	regulatory phosphorylation site [posttranslational modification]; other site
1218933001006	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
1218933001007	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1218933001008	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1218933001009	hinge; other site
1218933001010	active site
1218933001011	serine endoprotease; Provisional; Region: PRK10898
1218933001012	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1218933001013	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1218933001014	protein binding site [polypeptide binding]; other site
1218933001015	serine endoprotease; Provisional; Region: PRK10139
1218933001016	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1218933001017	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1218933001018	protein binding site [polypeptide binding]; other site
1218933001019	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1218933001020	hypothetical protein; Provisional; Region: PRK11677
1218933001021	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
1218933001022	Predicted ATPase [General function prediction only]; Region: COG1485
1218933001023	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1218933001024	23S rRNA interface [nucleotide binding]; other site
1218933001025	L3 interface [polypeptide binding]; other site
1218933001026	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1218933001027	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933001028	metabolite-proton symporter; Region: 2A0106; TIGR00883
1218933001029	putative substrate translocation pore; other site
1218933001030	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
1218933001031	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
1218933001032	putative NAD(P) binding site [chemical binding]; other site
1218933001033	catalytic Zn binding site [ion binding]; other site
1218933001034	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
1218933001035	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1218933001036	NADP binding site [chemical binding]; other site
1218933001037	homodimer interface [polypeptide binding]; other site
1218933001038	active site
1218933001039	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1218933001040	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933001041	DNA-binding site [nucleotide binding]; DNA binding site
1218933001042	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1218933001043	FCD domain; Region: FCD; pfam07729
1218933001044	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
1218933001045	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1218933001046	metal binding site [ion binding]; metal-binding site
1218933001047	substrate binding pocket [chemical binding]; other site
1218933001048	stringent starvation protein A; Provisional; Region: sspA; PRK09481
1218933001049	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
1218933001050	C-terminal domain interface [polypeptide binding]; other site
1218933001051	putative GSH binding site (G-site) [chemical binding]; other site
1218933001052	dimer interface [polypeptide binding]; other site
1218933001053	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
1218933001054	dimer interface [polypeptide binding]; other site
1218933001055	N-terminal domain interface [polypeptide binding]; other site
1218933001056	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
1218933001057	acetoin reductase; Validated; Region: PRK08643
1218933001058	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
1218933001059	NAD binding site [chemical binding]; other site
1218933001060	homotetramer interface [polypeptide binding]; other site
1218933001061	homodimer interface [polypeptide binding]; other site
1218933001062	active site
1218933001063	substrate binding site [chemical binding]; other site
1218933001064	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
1218933001065	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
1218933001066	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1218933001067	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1218933001068	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1218933001069	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1218933001070	active site
1218933001071	dimer interface [polypeptide binding]; other site
1218933001072	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1218933001073	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1218933001074	active site
1218933001075	FMN binding site [chemical binding]; other site
1218933001076	substrate binding site [chemical binding]; other site
1218933001077	3Fe-4S cluster binding site [ion binding]; other site
1218933001078	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1218933001079	domain interface; other site
1218933001080	radical SAM protein, TIGR01212 family; Region: TIGR01212
1218933001081	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
1218933001082	FeS/SAM binding site; other site
1218933001083	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
1218933001084	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1218933001085	putative active site [active]
1218933001086	heme pocket [chemical binding]; other site
1218933001087	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1218933001088	dimer interface [polypeptide binding]; other site
1218933001089	phosphorylation site [posttranslational modification]
1218933001090	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933001091	ATP binding site [chemical binding]; other site
1218933001092	Mg2+ binding site [ion binding]; other site
1218933001093	G-X-G motif; other site
1218933001094	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933001095	active site
1218933001096	phosphorylation site [posttranslational modification]
1218933001097	intermolecular recognition site; other site
1218933001098	dimerization interface [polypeptide binding]; other site
1218933001099	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1218933001100	putative binding surface; other site
1218933001101	active site
1218933001102	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
1218933001103	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
1218933001104	conserved cys residue [active]
1218933001105	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
1218933001106	Transglycosylase; Region: Transgly; cl17702
1218933001107	Alginate lyase; Region: Alginate_lyase; pfam05426
1218933001108	outer membrane lipoprotein; Provisional; Region: PRK11023
1218933001109	BON domain; Region: BON; pfam04972
1218933001110	BON domain; Region: BON; pfam04972
1218933001111	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1218933001112	dimer interface [polypeptide binding]; other site
1218933001113	active site
1218933001114	hypothetical protein; Reviewed; Region: PRK12497
1218933001115	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
1218933001116	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
1218933001117	putative ligand binding site [chemical binding]; other site
1218933001118	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
1218933001119	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1218933001120	putative SAM binding site [chemical binding]; other site
1218933001121	putative homodimer interface [polypeptide binding]; other site
1218933001122	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
1218933001123	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1218933001124	putative active site [active]
1218933001125	metal binding site [ion binding]; metal-binding site
1218933001126	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
1218933001127	hypothetical protein; Provisional; Region: PRK11653
1218933001128	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
1218933001129	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
1218933001130	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1218933001131	dimer interface [polypeptide binding]; other site
1218933001132	ADP-ribose binding site [chemical binding]; other site
1218933001133	active site
1218933001134	nudix motif; other site
1218933001135	metal binding site [ion binding]; metal-binding site
1218933001136	putative dehydrogenase; Provisional; Region: PRK11039
1218933001137	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1218933001138	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1218933001139	active site
1218933001140	metal binding site [ion binding]; metal-binding site
1218933001141	hexamer interface [polypeptide binding]; other site
1218933001142	esterase YqiA; Provisional; Region: PRK11071
1218933001143	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1218933001144	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1218933001145	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933001146	ATP binding site [chemical binding]; other site
1218933001147	Mg2+ binding site [ion binding]; other site
1218933001148	G-X-G motif; other site
1218933001149	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1218933001150	anchoring element; other site
1218933001151	dimer interface [polypeptide binding]; other site
1218933001152	ATP binding site [chemical binding]; other site
1218933001153	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1218933001154	active site
1218933001155	metal binding site [ion binding]; metal-binding site
1218933001156	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1218933001157	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1218933001158	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1218933001159	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1218933001160	classical (c) SDRs; Region: SDR_c; cd05233
1218933001161	NAD(P) binding site [chemical binding]; other site
1218933001162	active site
1218933001163	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933001164	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933001165	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1218933001166	dimerization interface [polypeptide binding]; other site
1218933001167	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1218933001168	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1218933001169	intersubunit interface [polypeptide binding]; other site
1218933001170	active site
1218933001171	zinc binding site [ion binding]; other site
1218933001172	Na+ binding site [ion binding]; other site
1218933001173	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1218933001174	intersubunit interface [polypeptide binding]; other site
1218933001175	active site
1218933001176	zinc binding site [ion binding]; other site
1218933001177	Na+ binding site [ion binding]; other site
1218933001178	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1218933001179	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1218933001180	active site
1218933001181	P-loop; other site
1218933001182	phosphorylation site [posttranslational modification]
1218933001183	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1218933001184	active site
1218933001185	phosphorylation site [posttranslational modification]
1218933001186	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1218933001187	HTH domain; Region: HTH_11; pfam08279
1218933001188	Mga helix-turn-helix domain; Region: Mga; pfam05043
1218933001189	PRD domain; Region: PRD; pfam00874
1218933001190	PRD domain; Region: PRD; pfam00874
1218933001191	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1218933001192	active site
1218933001193	P-loop; other site
1218933001194	phosphorylation site [posttranslational modification]
1218933001195	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
1218933001196	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933001197	N-terminal plug; other site
1218933001198	ligand-binding site [chemical binding]; other site
1218933001199	SUKH-3 immunity protein; Region: SUKH-3; pfam14433
1218933001200	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1218933001201	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1218933001202	CAP-like domain; other site
1218933001203	active site
1218933001204	primary dimer interface [polypeptide binding]; other site
1218933001205	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
1218933001206	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1218933001207	putative acyl-acceptor binding pocket; other site
1218933001208	FtsI repressor; Provisional; Region: PRK10883
1218933001209	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1218933001210	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1218933001211	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1218933001212	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933001213	DNA-binding site [nucleotide binding]; DNA binding site
1218933001214	UTRA domain; Region: UTRA; pfam07702
1218933001215	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1218933001216	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1218933001217	active site
1218933001218	catalytic tetrad [active]
1218933001219	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
1218933001220	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1218933001221	dimer interface [polypeptide binding]; other site
1218933001222	active site
1218933001223	metal binding site [ion binding]; metal-binding site
1218933001224	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1218933001225	dimer interface [polypeptide binding]; other site
1218933001226	FMN binding site [chemical binding]; other site
1218933001227	NADPH bind site [chemical binding]; other site
1218933001228	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1218933001229	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1218933001230	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933001231	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933001232	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1218933001233	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1218933001234	cystathionine beta-lyase; Provisional; Region: PRK08114
1218933001235	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1218933001236	homodimer interface [polypeptide binding]; other site
1218933001237	substrate-cofactor binding pocket; other site
1218933001238	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933001239	catalytic residue [active]
1218933001240	DctM-like transporters; Region: DctM; pfam06808
1218933001241	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1218933001242	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1218933001243	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1218933001244	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1218933001245	biopolymer transport protein ExbB; Provisional; Region: PRK10414
1218933001246	biopolymer transport protein ExbD; Provisional; Region: PRK11267
1218933001247	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1218933001248	D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417
1218933001249	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1218933001250	DNA binding site [nucleotide binding]
1218933001251	domain linker motif; other site
1218933001252	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
1218933001253	dimerization interface [polypeptide binding]; other site
1218933001254	ligand binding site [chemical binding]; other site
1218933001255	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
1218933001256	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1218933001257	substrate binding [chemical binding]; other site
1218933001258	active site
1218933001259	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1218933001260	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1218933001261	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1218933001262	active site turn [active]
1218933001263	phosphorylation site [posttranslational modification]
1218933001264	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1218933001265	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
1218933001266	trimer interface; other site
1218933001267	sugar binding site [chemical binding]; other site
1218933001268	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1218933001269	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1218933001270	putative substrate binding site [chemical binding]; other site
1218933001271	putative ATP binding site [chemical binding]; other site
1218933001272	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
1218933001273	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1218933001274	helicase Cas3; Provisional; Region: PRK09694
1218933001275	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
1218933001276	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1218933001277	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1218933001278	non-specific DNA binding site [nucleotide binding]; other site
1218933001279	salt bridge; other site
1218933001280	sequence-specific DNA binding site [nucleotide binding]; other site
1218933001281	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729
1218933001282	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731
1218933001283	CT1975-like protein; Region: Cas_CT1975; pfam09344
1218933001284	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cl17348
1218933001285	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
1218933001286	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
1218933001287	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
1218933001288	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648
1218933001289	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
1218933001290	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1218933001291	catalytic residue [active]
1218933001292	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1218933001293	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933001294	putative substrate translocation pore; other site
1218933001295	Predicted transcriptional regulators [Transcription]; Region: COG1733
1218933001296	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1218933001297	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897
1218933001298	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
1218933001299	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1218933001300	NAD binding site [chemical binding]; other site
1218933001301	active site
1218933001302	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
1218933001303	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1218933001304	FeS/SAM binding site; other site
1218933001305	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
1218933001306	ATP cone domain; Region: ATP-cone; pfam03477
1218933001307	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1218933001308	effector binding site; other site
1218933001309	active site
1218933001310	Zn binding site [ion binding]; other site
1218933001311	glycine loop; other site
1218933001312	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1218933001313	homotrimer interaction site [polypeptide binding]; other site
1218933001314	putative active site [active]
1218933001315	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
1218933001316	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
1218933001317	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
1218933001318	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
1218933001319	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1218933001320	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1218933001321	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
1218933001322	ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515
1218933001323	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1218933001324	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1218933001325	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076
1218933001326	RNase E inhibitor protein; Provisional; Region: PRK11191
1218933001327	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933001328	Coenzyme A binding pocket [chemical binding]; other site
1218933001329	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1218933001330	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
1218933001331	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1218933001332	hypothetical protein; Provisional; Region: PRK06489
1218933001333	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1218933001334	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
1218933001335	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933001336	dimerization interface [polypeptide binding]; other site
1218933001337	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1218933001338	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933001339	dimer interface [polypeptide binding]; other site
1218933001340	putative CheW interface [polypeptide binding]; other site
1218933001341	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
1218933001342	RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885
1218933001343	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1218933001344	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1218933001345	HIGH motif; other site
1218933001346	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1218933001347	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1218933001348	active site
1218933001349	KMSKS motif; other site
1218933001350	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1218933001351	tRNA binding surface [nucleotide binding]; other site
1218933001352	anticodon binding site; other site
1218933001353	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1218933001354	DNA polymerase III subunit chi; Validated; Region: PRK05728
1218933001355	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1218933001356	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1218933001357	interface (dimer of trimers) [polypeptide binding]; other site
1218933001358	Substrate-binding/catalytic site; other site
1218933001359	Zn-binding sites [ion binding]; other site
1218933001360	lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120
1218933001361	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1218933001362	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
1218933001363	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1218933001364	integrase; Provisional; Region: PRK09692
1218933001365	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1218933001366	active site
1218933001367	Int/Topo IB signature motif; other site
1218933001368	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1218933001369	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1218933001370	active site
1218933001371	ATP binding site [chemical binding]; other site
1218933001372	substrate binding site [chemical binding]; other site
1218933001373	activation loop (A-loop); other site
1218933001374	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1218933001375	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1218933001376	active site
1218933001377	ATP binding site [chemical binding]; other site
1218933001378	substrate binding site [chemical binding]; other site
1218933001379	activation loop (A-loop); other site
1218933001380	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
1218933001381	active site
1218933001382	Predicted transcriptional regulator [Transcription]; Region: COG3905
1218933001383	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
1218933001384	AAA domain; Region: AAA_33; pfam13671
1218933001385	AAA domain; Region: AAA_17; pfam13207
1218933001386	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1218933001387	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1218933001388	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1218933001389	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1218933001390	FtsX-like permease family; Region: FtsX; pfam02687
1218933001391	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1218933001392	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
1218933001393	Walker A/P-loop; other site
1218933001394	ATP binding site [chemical binding]; other site
1218933001395	Q-loop/lid; other site
1218933001396	ABC transporter signature motif; other site
1218933001397	Walker B; other site
1218933001398	D-loop; other site
1218933001399	H-loop/switch region; other site
1218933001400	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1218933001401	metal ion-dependent adhesion site (MIDAS); other site
1218933001402	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
1218933001403	Putative bacterial virulence factor; Region: Virul_Fac; pfam10139
1218933001404	Virulence factor SrfB; Region: SrfB; pfam07520
1218933001405	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1218933001406	metal ion-dependent adhesion site (MIDAS); other site
1218933001407	Uncharacterized conserved protein [Function unknown]; Region: COG2850
1218933001408	Secretory lipase; Region: LIP; pfam03583
1218933001409	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1218933001410	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1218933001411	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1218933001412	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1218933001413	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1218933001414	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1218933001415	HlyD family secretion protein; Region: HlyD_3; pfam13437
1218933001416	Outer membrane efflux protein; Region: OEP; pfam02321
1218933001417	Outer membrane efflux protein; Region: OEP; pfam02321
1218933001418	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1218933001419	Aspartase; Region: Aspartase; cd01357
1218933001420	active sites [active]
1218933001421	tetramer interface [polypeptide binding]; other site
1218933001422	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933001423	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933001424	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1218933001425	dimerization interface [polypeptide binding]; other site
1218933001426	FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244
1218933001427	dimer interface [polypeptide binding]; other site
1218933001428	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1218933001429	Mn binding site [ion binding]; other site
1218933001430	K binding site [ion binding]; other site
1218933001431	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
1218933001432	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
1218933001433	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933001434	Walker A motif; other site
1218933001435	ATP binding site [chemical binding]; other site
1218933001436	Walker B motif; other site
1218933001437	arginine finger; other site
1218933001438	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
1218933001439	hypothetical protein; Reviewed; Region: PRK09588
1218933001440	HEAT repeats; Region: HEAT_2; pfam13646
1218933001441	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
1218933001442	HNH endonuclease; Region: HNH_2; pfam13391
1218933001443	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
1218933001444	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1218933001445	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1218933001446	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
1218933001447	dimer interface [polypeptide binding]; other site
1218933001448	active site clefts [active]
1218933001449	zinc binding site [ion binding]; other site
1218933001450	Nitrate and nitrite sensing; Region: NIT; pfam08376
1218933001451	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1218933001452	HAMP domain; Region: HAMP; pfam00672
1218933001453	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933001454	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933001455	dimer interface [polypeptide binding]; other site
1218933001456	putative CheW interface [polypeptide binding]; other site
1218933001457	magnesium-transporting ATPase; Provisional; Region: PRK15122
1218933001458	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1218933001459	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1218933001460	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1218933001461	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1218933001462	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1218933001463	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1218933001464	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1218933001465	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1218933001466	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933001467	dimer interface [polypeptide binding]; other site
1218933001468	putative CheW interface [polypeptide binding]; other site
1218933001469	L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625
1218933001470	rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634
1218933001471	intersubunit interface [polypeptide binding]; other site
1218933001472	active site
1218933001473	Zn2+ binding site [ion binding]; other site
1218933001474	L-rhamnose isomerase; Provisional; Region: PRK01076
1218933001475	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
1218933001476	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
1218933001477	N- and C-terminal domain interface [polypeptide binding]; other site
1218933001478	active site
1218933001479	putative catalytic site [active]
1218933001480	metal binding site [ion binding]; metal-binding site
1218933001481	ATP binding site [chemical binding]; other site
1218933001482	rhamnulokinase; Provisional; Region: rhaB; PRK10640
1218933001483	carbohydrate binding site [chemical binding]; other site
1218933001484	transcriptional activator RhaS; Provisional; Region: PRK13503
1218933001485	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1218933001486	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933001487	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933001488	transcriptional activator RhaR; Provisional; Region: PRK13501
1218933001489	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1218933001490	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933001491	Predicted transcriptional regulator [Transcription]; Region: COG3905
1218933001492	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
1218933001493	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1218933001494	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933001495	Walker A/P-loop; other site
1218933001496	ATP binding site [chemical binding]; other site
1218933001497	Q-loop/lid; other site
1218933001498	ABC transporter signature motif; other site
1218933001499	Walker B; other site
1218933001500	D-loop; other site
1218933001501	H-loop/switch region; other site
1218933001502	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1218933001503	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933001504	Walker A/P-loop; other site
1218933001505	ATP binding site [chemical binding]; other site
1218933001506	Q-loop/lid; other site
1218933001507	ABC transporter signature motif; other site
1218933001508	Walker B; other site
1218933001509	D-loop; other site
1218933001510	H-loop/switch region; other site
1218933001511	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1218933001512	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1218933001513	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933001514	dimer interface [polypeptide binding]; other site
1218933001515	conserved gate region; other site
1218933001516	putative PBP binding loops; other site
1218933001517	ABC-ATPase subunit interface; other site
1218933001518	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1218933001519	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1218933001520	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1218933001521	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
1218933001522	Protein of unknown function (DUF1440); Region: DUF1440; pfam07274
1218933001523	Domain of unknown function (DUF4265); Region: DUF4265; pfam14085
1218933001524	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
1218933001525	RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776
1218933001526	hypothetical protein; Provisional; Region: PRK05208
1218933001527	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1218933001528	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1218933001529	NAD(P) binding site [chemical binding]; other site
1218933001530	substrate binding site [chemical binding]; other site
1218933001531	dimer interface [polypeptide binding]; other site
1218933001532	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
1218933001533	Protein of unknown function (DUF796); Region: DUF796; cl01226
1218933001534	oxidoreductase; Provisional; Region: PRK08013
1218933001535	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
1218933001536	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
1218933001537	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
1218933001538	proline aminopeptidase P II; Provisional; Region: PRK10879
1218933001539	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
1218933001540	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1218933001541	active site
1218933001542	hypothetical protein; Reviewed; Region: PRK01736
1218933001543	Z-ring-associated protein; Provisional; Region: PRK10972
1218933001544	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1218933001545	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
1218933001546	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1218933001547	non-specific DNA binding site [nucleotide binding]; other site
1218933001548	salt bridge; other site
1218933001549	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
1218933001550	sequence-specific DNA binding site [nucleotide binding]; other site
1218933001551	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
1218933001552	active site
1218933001553	(T/H)XGH motif; other site
1218933001554	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
1218933001555	DNA repair protein RadA; Region: sms; TIGR00416
1218933001556	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1218933001557	Walker A motif/ATP binding site; other site
1218933001558	ATP binding site [chemical binding]; other site
1218933001559	Walker B motif; other site
1218933001560	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1218933001561	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
1218933001562	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1218933001563	motif I; other site
1218933001564	motif II; other site
1218933001565	hypothetical protein; Provisional; Region: PRK11246
1218933001566	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1218933001567	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1218933001568	G1 box; other site
1218933001569	putative GEF interaction site [polypeptide binding]; other site
1218933001570	GTP/Mg2+ binding site [chemical binding]; other site
1218933001571	Switch I region; other site
1218933001572	G2 box; other site
1218933001573	G3 box; other site
1218933001574	Switch II region; other site
1218933001575	G4 box; other site
1218933001576	G5 box; other site
1218933001577	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1218933001578	periplasmic protein; Provisional; Region: PRK10568
1218933001579	BON domain; Region: BON; pfam04972
1218933001580	BON domain; Region: BON; pfam04972
1218933001581	CsbD-like; Region: CsbD; cl17424
1218933001582	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1218933001583	active site
1218933001584	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1218933001585	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1218933001586	Nucleoside recognition; Region: Gate; pfam07670
1218933001587	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1218933001588	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
1218933001589	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1218933001590	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
1218933001591	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933001592	N-terminal plug; other site
1218933001593	ligand-binding site [chemical binding]; other site
1218933001594	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933001595	putative substrate translocation pore; other site
1218933001596	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1218933001597	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
1218933001598	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1218933001599	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
1218933001600	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
1218933001601	acyl-activating enzyme (AAE) consensus motif; other site
1218933001602	active site
1218933001603	AMP binding site [chemical binding]; other site
1218933001604	substrate binding site [chemical binding]; other site
1218933001605	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
1218933001606	hydrophobic substrate binding pocket; other site
1218933001607	Isochorismatase family; Region: Isochorismatase; pfam00857
1218933001608	active site
1218933001609	conserved cis-peptide bond; other site
1218933001610	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
1218933001611	Condensation domain; Region: Condensation; pfam00668
1218933001612	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1218933001613	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1218933001614	acyl-activating enzyme (AAE) consensus motif; other site
1218933001615	AMP binding site [chemical binding]; other site
1218933001616	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1218933001617	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
1218933001618	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
1218933001619	putative NAD(P) binding site [chemical binding]; other site
1218933001620	active site
1218933001621	Condensation domain; Region: Condensation; pfam00668
1218933001622	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1218933001623	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1218933001624	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1218933001625	acyl-activating enzyme (AAE) consensus motif; other site
1218933001626	AMP binding site [chemical binding]; other site
1218933001627	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1218933001628	Condensation domain; Region: Condensation; pfam00668
1218933001629	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1218933001630	Condensation domain; Region: Condensation; pfam00668
1218933001631	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1218933001632	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
1218933001633	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1218933001634	acyl-activating enzyme (AAE) consensus motif; other site
1218933001635	AMP binding site [chemical binding]; other site
1218933001636	Domain of unknown function (DUF4034); Region: DUF4034; pfam13226
1218933001637	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1218933001638	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1218933001639	tetramer interface [polypeptide binding]; other site
1218933001640	active site
1218933001641	Mg2+/Mn2+ binding site [ion binding]; other site
1218933001642	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1218933001643	phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297
1218933001644	PYR/PP interface [polypeptide binding]; other site
1218933001645	dimer interface [polypeptide binding]; other site
1218933001646	TPP binding site [chemical binding]; other site
1218933001647	Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371
1218933001648	TPP-binding site; other site
1218933001649	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1218933001650	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
1218933001651	carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147
1218933001652	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
1218933001653	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
1218933001654	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
1218933001655	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933001656	Walker A/P-loop; other site
1218933001657	ATP binding site [chemical binding]; other site
1218933001658	Q-loop/lid; other site
1218933001659	ABC transporter signature motif; other site
1218933001660	Walker B; other site
1218933001661	D-loop; other site
1218933001662	H-loop/switch region; other site
1218933001663	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1218933001664	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
1218933001665	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933001666	Walker A/P-loop; other site
1218933001667	ATP binding site [chemical binding]; other site
1218933001668	Q-loop/lid; other site
1218933001669	ABC transporter signature motif; other site
1218933001670	Walker B; other site
1218933001671	D-loop; other site
1218933001672	H-loop/switch region; other site
1218933001673	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
1218933001674	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1218933001675	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
1218933001676	active site
1218933001677	ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078
1218933001678	active site
1218933001679	carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244
1218933001680	putative hydrolase; Provisional; Region: PRK02113
1218933001681	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933001682	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933001683	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1218933001684	putative effector binding pocket; other site
1218933001685	dimerization interface [polypeptide binding]; other site
1218933001686	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
1218933001687	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1218933001688	Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459
1218933001689	Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693
1218933001690	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1218933001691	Helix-turn-helix domain; Region: HTH_18; pfam12833
1218933001692	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933001693	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1218933001694	putative transcriptional regulator; Provisional; Region: PRK11640
1218933001695	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1218933001696	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
1218933001697	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
1218933001698	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1218933001699	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
1218933001700	DsbD alpha interface [polypeptide binding]; other site
1218933001701	catalytic residues [active]
1218933001702	divalent-cation tolerance protein CutA; Provisional; Region: PRK10645
1218933001703	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
1218933001704	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
1218933001705	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1218933001706	Aspartase; Region: Aspartase; cd01357
1218933001707	active sites [active]
1218933001708	tetramer interface [polypeptide binding]; other site
1218933001709	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
1218933001710	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1218933001711	oligomerisation interface [polypeptide binding]; other site
1218933001712	mobile loop; other site
1218933001713	roof hairpin; other site
1218933001714	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1218933001715	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1218933001716	ring oligomerisation interface [polypeptide binding]; other site
1218933001717	ATP/Mg binding site [chemical binding]; other site
1218933001718	stacking interactions; other site
1218933001719	hinge regions; other site
1218933001720	chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655
1218933001721	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
1218933001722	UbiA prenyltransferase family; Region: UbiA; pfam01040
1218933001723	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
1218933001724	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
1218933001725	putative acyl-acceptor binding pocket; other site
1218933001726	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1218933001727	LexA repressor; Validated; Region: PRK00215
1218933001728	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1218933001729	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1218933001730	Catalytic site [active]
1218933001731	hypothetical protein; Provisional; Region: PRK10428
1218933001732	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1218933001733	metal binding site 2 [ion binding]; metal-binding site
1218933001734	putative DNA binding helix; other site
1218933001735	metal binding site 1 [ion binding]; metal-binding site
1218933001736	dimer interface [polypeptide binding]; other site
1218933001737	structural Zn2+ binding site [ion binding]; other site
1218933001738	Pirin-related protein [General function prediction only]; Region: COG1741
1218933001739	Pirin; Region: Pirin; pfam02678
1218933001740	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933001741	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
1218933001742	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1218933001743	dimerization interface [polypeptide binding]; other site
1218933001744	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
1218933001745	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
1218933001746	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
1218933001747	putative dimer interface [polypeptide binding]; other site
1218933001748	N-terminal domain interface [polypeptide binding]; other site
1218933001749	putative substrate binding pocket (H-site) [chemical binding]; other site
1218933001750	Predicted membrane protein [Function unknown]; Region: COG2259
1218933001751	YqjK-like protein; Region: YqjK; pfam13997
1218933001752	Predicted membrane protein [Function unknown]; Region: COG5393
1218933001753	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
1218933001754	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
1218933001755	SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136
1218933001756	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1218933001757	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1218933001758	DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523
1218933001759	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933001760	DNA-binding site [nucleotide binding]; DNA binding site
1218933001761	FCD domain; Region: FCD; pfam07729
1218933001762	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933001763	D-galactonate transporter; Region: 2A0114; TIGR00893
1218933001764	putative substrate translocation pore; other site
1218933001765	Glucuronate isomerase; Region: UxaC; pfam02614
1218933001766	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
1218933001767	altronate oxidoreductase; Provisional; Region: PRK03643
1218933001768	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1218933001769	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1218933001770	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1218933001771	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1218933001772	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1218933001773	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
1218933001774	serine/threonine transporter SstT; Provisional; Region: PRK13628
1218933001775	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1218933001776	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
1218933001777	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1218933001778	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1218933001779	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
1218933001780	Methyltransferase small domain; Region: MTS; pfam05175
1218933001781	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1218933001782	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
1218933001783	active site
1218933001784	FMN binding site [chemical binding]; other site
1218933001785	2,4-decadienoyl-CoA binding site; other site
1218933001786	catalytic residue [active]
1218933001787	4Fe-4S cluster binding site [ion binding]; other site
1218933001788	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1218933001789	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1218933001790	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
1218933001791	dimer interface [polypeptide binding]; other site
1218933001792	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1218933001793	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1218933001794	metal binding site [ion binding]; metal-binding site
1218933001795	active site
1218933001796	I-site; other site
1218933001797	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544
1218933001798	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
1218933001799	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1218933001800	active site turn [active]
1218933001801	phosphorylation site [posttranslational modification]
1218933001802	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1218933001803	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1218933001804	HPr interaction site; other site
1218933001805	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1218933001806	active site
1218933001807	phosphorylation site [posttranslational modification]
1218933001808	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1218933001809	beta-galactosidase; Region: BGL; TIGR03356
1218933001810	Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566
1218933001811	Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566
1218933001812	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
1218933001813	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1218933001814	molybdopterin cofactor binding site; other site
1218933001815	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1218933001816	molybdopterin cofactor binding site; other site
1218933001817	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
1218933001818	Flavodoxin; Region: Flavodoxin_1; pfam00258
1218933001819	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
1218933001820	FAD binding pocket [chemical binding]; other site
1218933001821	FAD binding motif [chemical binding]; other site
1218933001822	catalytic residues [active]
1218933001823	NAD binding pocket [chemical binding]; other site
1218933001824	phosphate binding motif [ion binding]; other site
1218933001825	beta-alpha-beta structure motif; other site
1218933001826	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
1218933001827	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1218933001828	potential catalytic triad [active]
1218933001829	conserved cys residue [active]
1218933001830	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933001831	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933001832	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
1218933001833	putative effector binding pocket; other site
1218933001834	putative dimerization interface [polypeptide binding]; other site
1218933001835	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1218933001836	integrase; Provisional; Region: int; PHA02601
1218933001837	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1218933001838	active site
1218933001839	DNA binding site [nucleotide binding]
1218933001840	Int/Topo IB signature motif; other site
1218933001841	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
1218933001842	active site
1218933001843	SUMO-1 interface [polypeptide binding]; other site
1218933001844	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
1218933001845	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1218933001846	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1218933001847	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
1218933001848	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1218933001849	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1218933001850	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1218933001851	DNA binding residues [nucleotide binding]
1218933001852	DNA primase; Validated; Region: dnaG; PRK05667
1218933001853	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1218933001854	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1218933001855	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1218933001856	active site
1218933001857	metal binding site [ion binding]; metal-binding site
1218933001858	interdomain interaction site; other site
1218933001859	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1218933001860	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
1218933001861	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1218933001862	UGMP family protein; Validated; Region: PRK09604
1218933001863	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1218933001864	arginine repressor; Provisional; Region: PRK05066
1218933001865	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1218933001866	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1218933001867	malate dehydrogenase; Provisional; Region: PRK05086
1218933001868	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
1218933001869	NAD binding site [chemical binding]; other site
1218933001870	dimerization interface [polypeptide binding]; other site
1218933001871	Substrate binding site [chemical binding]; other site
1218933001872	Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693
1218933001873	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
1218933001874	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
1218933001875	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1218933001876	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1218933001877	substrate binding pocket [chemical binding]; other site
1218933001878	chain length determination region; other site
1218933001879	substrate-Mg2+ binding site; other site
1218933001880	catalytic residues [active]
1218933001881	aspartate-rich region 1; other site
1218933001882	active site lid residues [active]
1218933001883	aspartate-rich region 2; other site
1218933001884	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1218933001885	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1218933001886	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1218933001887	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1218933001888	EamA-like transporter family; Region: EamA; pfam00892
1218933001889	EamA-like transporter family; Region: EamA; cl17759
1218933001890	GTPase CgtA; Reviewed; Region: obgE; PRK12298
1218933001891	GTP1/OBG; Region: GTP1_OBG; pfam01018
1218933001892	Obg GTPase; Region: Obg; cd01898
1218933001893	G1 box; other site
1218933001894	GTP/Mg2+ binding site [chemical binding]; other site
1218933001895	Switch I region; other site
1218933001896	G2 box; other site
1218933001897	G3 box; other site
1218933001898	Switch II region; other site
1218933001899	G4 box; other site
1218933001900	G5 box; other site
1218933001901	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
1218933001902	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1218933001903	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1218933001904	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1218933001905	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1218933001906	RNA-binding protein YhbY; Provisional; Region: PRK10343
1218933001907	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
1218933001908	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933001909	S-adenosylmethionine binding site [chemical binding]; other site
1218933001910	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
1218933001911	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933001912	Walker A motif; other site
1218933001913	ATP binding site [chemical binding]; other site
1218933001914	Walker B motif; other site
1218933001915	arginine finger; other site
1218933001916	Peptidase family M41; Region: Peptidase_M41; pfam01434
1218933001917	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1218933001918	dihydropteroate synthase; Region: DHPS; TIGR01496
1218933001919	substrate binding pocket [chemical binding]; other site
1218933001920	dimer interface [polypeptide binding]; other site
1218933001921	inhibitor binding site; inhibition site
1218933001922	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
1218933001923	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1218933001924	active site
1218933001925	substrate binding site [chemical binding]; other site
1218933001926	metal binding site [ion binding]; metal-binding site
1218933001927	Preprotein translocase SecG subunit; Region: SecG; pfam03840
1218933001928	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1218933001929	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1218933001930	NAD(P) binding site [chemical binding]; other site
1218933001931	substrate binding site [chemical binding]; other site
1218933001932	dimer interface [polypeptide binding]; other site
1218933001933	Condensation domain; Region: Condensation; pfam00668
1218933001934	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1218933001935	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1218933001936	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1218933001937	acyl-activating enzyme (AAE) consensus motif; other site
1218933001938	AMP binding site [chemical binding]; other site
1218933001939	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1218933001940	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1218933001941	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1218933001942	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1218933001943	KR domain; Region: KR; pfam08659
1218933001944	putative NADP binding site [chemical binding]; other site
1218933001945	active site
1218933001946	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1218933001947	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1218933001948	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1218933001949	active site
1218933001950	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1218933001951	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1218933001952	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1218933001953	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1218933001954	acyl-activating enzyme (AAE) consensus motif; other site
1218933001955	AMP binding site [chemical binding]; other site
1218933001956	Protein of unknown function (DUF2589); Region: DUF2589; pfam11655
1218933001957	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1218933001958	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1218933001959	acyl-activating enzyme (AAE) consensus motif; other site
1218933001960	AMP binding site [chemical binding]; other site
1218933001961	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1218933001962	Condensation domain; Region: Condensation; pfam00668
1218933001963	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1218933001964	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1218933001965	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
1218933001966	catalytic residues [active]
1218933001967	Protein of unknown function (DUF2589); Region: DUF2589; pfam11655
1218933001968	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1218933001969	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1218933001970	DNA binding residues [nucleotide binding]
1218933001971	dimerization interface [polypeptide binding]; other site
1218933001972	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1218933001973	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1218933001974	putative oligomer interface [polypeptide binding]; other site
1218933001975	putative RNA binding site [nucleotide binding]; other site
1218933001976	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
1218933001977	NusA N-terminal domain; Region: NusA_N; pfam08529
1218933001978	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1218933001979	RNA binding site [nucleotide binding]; other site
1218933001980	homodimer interface [polypeptide binding]; other site
1218933001981	NusA-like KH domain; Region: KH_5; pfam13184
1218933001982	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1218933001983	G-X-X-G motif; other site
1218933001984	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1218933001985	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1218933001986	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1218933001987	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
1218933001988	translation initiation factor IF-2; Region: IF-2; TIGR00487
1218933001989	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1218933001990	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1218933001991	G1 box; other site
1218933001992	putative GEF interaction site [polypeptide binding]; other site
1218933001993	GTP/Mg2+ binding site [chemical binding]; other site
1218933001994	Switch I region; other site
1218933001995	G2 box; other site
1218933001996	G3 box; other site
1218933001997	Switch II region; other site
1218933001998	G4 box; other site
1218933001999	G5 box; other site
1218933002000	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1218933002001	Translation-initiation factor 2; Region: IF-2; pfam11987
1218933002002	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1218933002003	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1218933002004	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
1218933002005	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1218933002006	RNA binding site [nucleotide binding]; other site
1218933002007	active site
1218933002008	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
1218933002009	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1218933002010	16S/18S rRNA binding site [nucleotide binding]; other site
1218933002011	S13e-L30e interaction site [polypeptide binding]; other site
1218933002012	25S rRNA binding site [nucleotide binding]; other site
1218933002013	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1218933002014	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1218933002015	RNase E interface [polypeptide binding]; other site
1218933002016	trimer interface [polypeptide binding]; other site
1218933002017	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1218933002018	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1218933002019	RNase E interface [polypeptide binding]; other site
1218933002020	trimer interface [polypeptide binding]; other site
1218933002021	active site
1218933002022	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1218933002023	putative nucleic acid binding region [nucleotide binding]; other site
1218933002024	G-X-X-G motif; other site
1218933002025	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1218933002026	RNA binding site [nucleotide binding]; other site
1218933002027	domain interface; other site
1218933002028	lipoprotein NlpI; Provisional; Region: PRK11189
1218933002029	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1218933002030	binding surface
1218933002031	TPR motif; other site
1218933002032	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1218933002033	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1218933002034	ATP binding site [chemical binding]; other site
1218933002035	Mg++ binding site [ion binding]; other site
1218933002036	motif III; other site
1218933002037	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1218933002038	nucleotide binding region [chemical binding]; other site
1218933002039	ATP-binding site [chemical binding]; other site
1218933002040	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
1218933002041	putative RNA binding site [nucleotide binding]; other site
1218933002042	hypothetical protein; Provisional; Region: PRK10508
1218933002043	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1218933002044	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1218933002045	putative protease; Provisional; Region: PRK15447
1218933002046	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1218933002047	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1218933002048	Peptidase family U32; Region: Peptidase_U32; pfam01136
1218933002049	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
1218933002050	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933002051	Coenzyme A binding pocket [chemical binding]; other site
1218933002052	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
1218933002053	amidohydrolase; Region: amidohydrolases; TIGR01891
1218933002054	putative metal binding site [ion binding]; other site
1218933002055	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1218933002056	intersubunit interface [polypeptide binding]; other site
1218933002057	active site
1218933002058	catalytic residue [active]
1218933002059	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
1218933002060	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1218933002061	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1218933002062	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
1218933002063	phosphopentomutase; Provisional; Region: PRK05362
1218933002064	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1218933002065	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1218933002066	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1218933002067	putative monooxygenase; Provisional; Region: PRK11118
1218933002068	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
1218933002069	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
1218933002070	catalytic residues [active]
1218933002071	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933002072	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933002073	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1218933002074	dimerization interface [polypeptide binding]; other site
1218933002075	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1218933002076	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
1218933002077	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
1218933002078	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
1218933002079	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933002080	N-terminal plug; other site
1218933002081	ligand-binding site [chemical binding]; other site
1218933002082	fec operon regulator FecR; Reviewed; Region: PRK09774
1218933002083	FecR protein; Region: FecR; pfam04773
1218933002084	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
1218933002085	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1218933002086	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1218933002087	DNA binding residues [nucleotide binding]
1218933002088	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933002089	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1218933002090	dimerization interface [polypeptide binding]; other site
1218933002091	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1218933002092	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1218933002093	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1218933002094	sugar binding site [chemical binding]; other site
1218933002095	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
1218933002096	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933002097	Coenzyme A binding pocket [chemical binding]; other site
1218933002098	DNA polymerase III subunit psi; Validated; Region: PRK06856
1218933002099	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
1218933002100	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
1218933002101	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933002102	S-adenosylmethionine binding site [chemical binding]; other site
1218933002103	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1218933002104	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1218933002105	active site
1218933002106	catalytic tetrad [active]
1218933002107	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933002108	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933002109	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1218933002110	putative effector binding pocket; other site
1218933002111	putative dimerization interface [polypeptide binding]; other site
1218933002112	Protein of unknown function (DUF1435); Region: DUF1435; pfam07256
1218933002113	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933002114	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933002115	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
1218933002116	putative dimerization interface [polypeptide binding]; other site
1218933002117	putative substrate binding pocket [chemical binding]; other site
1218933002118	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
1218933002119	acetolactate synthase; Reviewed; Region: PRK08617
1218933002120	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1218933002121	PYR/PP interface [polypeptide binding]; other site
1218933002122	dimer interface [polypeptide binding]; other site
1218933002123	TPP binding site [chemical binding]; other site
1218933002124	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1218933002125	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1218933002126	TPP-binding site [chemical binding]; other site
1218933002127	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1218933002128	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
1218933002129	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
1218933002130	dimer interface [polypeptide binding]; other site
1218933002131	active site
1218933002132	metal binding site [ion binding]; metal-binding site
1218933002133	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1218933002134	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1218933002135	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1218933002136	lipoyl attachment site [posttranslational modification]; other site
1218933002137	glycine dehydrogenase; Provisional; Region: PRK05367
1218933002138	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1218933002139	tetramer interface [polypeptide binding]; other site
1218933002140	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933002141	catalytic residue [active]
1218933002142	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1218933002143	tetramer interface [polypeptide binding]; other site
1218933002144	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933002145	catalytic residue [active]
1218933002146	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1218933002147	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933002148	Coenzyme A binding pocket [chemical binding]; other site
1218933002149	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933002150	dimer interface [polypeptide binding]; other site
1218933002151	conserved gate region; other site
1218933002152	putative PBP binding loops; other site
1218933002153	ABC-ATPase subunit interface; other site
1218933002154	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1218933002155	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933002156	dimer interface [polypeptide binding]; other site
1218933002157	conserved gate region; other site
1218933002158	putative PBP binding loops; other site
1218933002159	ABC-ATPase subunit interface; other site
1218933002160	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1218933002161	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1218933002162	active site
1218933002163	metal binding site [ion binding]; metal-binding site
1218933002164	hexamer interface [polypeptide binding]; other site
1218933002165	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1218933002166	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1218933002167	Walker A/P-loop; other site
1218933002168	ATP binding site [chemical binding]; other site
1218933002169	Q-loop/lid; other site
1218933002170	ABC transporter signature motif; other site
1218933002171	Walker B; other site
1218933002172	D-loop; other site
1218933002173	H-loop/switch region; other site
1218933002174	TOBE domain; Region: TOBE_2; pfam08402
1218933002175	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1218933002176	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1218933002177	galactoside permease; Reviewed; Region: lacY; PRK09528
1218933002178	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933002179	putative substrate translocation pore; other site
1218933002180	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
1218933002181	Melibiase; Region: Melibiase; pfam02065
1218933002182	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1218933002183	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1218933002184	DNA binding site [nucleotide binding]
1218933002185	domain linker motif; other site
1218933002186	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
1218933002187	ligand binding site [chemical binding]; other site
1218933002188	HD domain; Region: HD_3; pfam13023
1218933002189	hemolysin; Provisional; Region: PRK15087
1218933002190	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1218933002191	putative global regulator; Reviewed; Region: PRK09559
1218933002192	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1218933002193	hypothetical protein; Provisional; Region: PRK10878
1218933002194	Protein of unknown function (DUF1434); Region: DUF1434; pfam07254
1218933002195	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
1218933002196	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933002197	S-adenosylmethionine binding site [chemical binding]; other site
1218933002198	flavodoxin FldB; Provisional; Region: PRK12359
1218933002199	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1218933002200	active site
1218933002201	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933002202	metabolite-proton symporter; Region: 2A0106; TIGR00883
1218933002203	putative substrate translocation pore; other site
1218933002204	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1218933002205	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1218933002206	active site
1218933002207	Int/Topo IB signature motif; other site
1218933002208	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
1218933002209	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
1218933002210	dimerization domain [polypeptide binding]; other site
1218933002211	dimer interface [polypeptide binding]; other site
1218933002212	catalytic residues [active]
1218933002213	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
1218933002214	DHH family; Region: DHH; pfam01368
1218933002215	DHHA1 domain; Region: DHHA1; pfam02272
1218933002216	peptide chain release factor 2; Validated; Region: prfB; PRK00578
1218933002217	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1218933002218	RF-1 domain; Region: RF-1; pfam00472
1218933002219	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1218933002220	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1218933002221	dimer interface [polypeptide binding]; other site
1218933002222	putative anticodon binding site; other site
1218933002223	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1218933002224	motif 1; other site
1218933002225	active site
1218933002226	motif 2; other site
1218933002227	motif 3; other site
1218933002228	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1218933002229	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1218933002230	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933002231	LysE type translocator; Region: LysE; cl00565
1218933002232	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1218933002233	V-type ATP synthase subunit I; Validated; Region: PRK05771
1218933002234	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
1218933002235	SnoaL-like domain; Region: SnoaL_3; pfam13474
1218933002236	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
1218933002237	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1218933002238	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1218933002239	putative acyl-acceptor binding pocket; other site
1218933002240	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
1218933002241	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1218933002242	Na binding site [ion binding]; other site
1218933002243	putative substrate binding site [chemical binding]; other site
1218933002244	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1218933002245	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933002246	DNA-binding site [nucleotide binding]; DNA binding site
1218933002247	FCD domain; Region: FCD; pfam07729
1218933002248	Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126
1218933002249	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
1218933002250	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
1218933002251	active site
1218933002252	catalytic site [active]
1218933002253	tetramer interface [polypeptide binding]; other site
1218933002254	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1218933002255	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
1218933002256	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1218933002257	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1218933002258	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933002259	active site
1218933002260	phosphorylation site [posttranslational modification]
1218933002261	intermolecular recognition site; other site
1218933002262	dimerization interface [polypeptide binding]; other site
1218933002263	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1218933002264	DNA binding site [nucleotide binding]
1218933002265	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1218933002266	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1218933002267	dimer interface [polypeptide binding]; other site
1218933002268	phosphorylation site [posttranslational modification]
1218933002269	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933002270	ATP binding site [chemical binding]; other site
1218933002271	Mg2+ binding site [ion binding]; other site
1218933002272	G-X-G motif; other site
1218933002273	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
1218933002274	Flp pilus assembly protein CpaB; Region: pilus_cpaB; TIGR03177
1218933002275	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
1218933002276	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
1218933002277	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1218933002278	pilus (Caulobacter type) biogenesis lipoprotein CpaD; Region: pilus_cpaD; TIGR02522
1218933002279	Type IV pili component [Cell motility and secretion]; Region: COG5461
1218933002280	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1218933002281	intermolecular recognition site; other site
1218933002282	active site
1218933002283	dimerization interface [polypeptide binding]; other site
1218933002284	AAA domain; Region: AAA_31; pfam13614
1218933002285	Type II/IV secretion system protein; Region: T2SE; pfam00437
1218933002286	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1218933002287	ATP binding site [chemical binding]; other site
1218933002288	Walker A motif; other site
1218933002289	hexamer interface [polypeptide binding]; other site
1218933002290	Walker B motif; other site
1218933002291	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1218933002292	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1218933002293	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
1218933002294	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1218933002295	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1218933002296	binding surface
1218933002297	TPR motif; other site
1218933002298	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1218933002299	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1218933002300	binding surface
1218933002301	TPR motif; other site
1218933002302	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1218933002303	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1218933002304	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
1218933002305	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1218933002306	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1218933002307	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1218933002308	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1218933002309	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
1218933002310	Putative Ig domain; Region: He_PIG; pfam05345
1218933002311	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1218933002312	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1218933002313	Cadherin repeat-like domain; Region: CA_like; cl15786
1218933002314	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
1218933002315	Ca2+ binding site [ion binding]; other site
1218933002316	Outer membrane efflux protein; Region: OEP; pfam02321
1218933002317	Outer membrane efflux protein; Region: OEP; pfam02321
1218933002318	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1218933002319	HlyD family secretion protein; Region: HlyD_3; pfam13437
1218933002320	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1218933002321	HlyD family secretion protein; Region: HlyD_3; pfam13437
1218933002322	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1218933002323	active site
1218933002324	putative substrate binding region [chemical binding]; other site
1218933002325	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1218933002326	HlyD family secretion protein; Region: HlyD_3; pfam13437
1218933002327	N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cd10320
1218933002328	active site
1218933002329	catalytic site [active]
1218933002330	Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316
1218933002331	C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317
1218933002332	Ca binding site [ion binding]; other site
1218933002333	substrate binding site [chemical binding]; other site
1218933002334	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1218933002335	putative transposase; Provisional; Region: PRK09857
1218933002336	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1218933002337	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1218933002338	Na binding site [ion binding]; other site
1218933002339	Predicted membrane protein [Function unknown]; Region: COG3162
1218933002340	acetyl-CoA synthetase; Provisional; Region: PRK00174
1218933002341	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1218933002342	active site
1218933002343	CoA binding site [chemical binding]; other site
1218933002344	acyl-activating enzyme (AAE) consensus motif; other site
1218933002345	AMP binding site [chemical binding]; other site
1218933002346	acetate binding site [chemical binding]; other site
1218933002347	Secretin and TonB N terminus short domain; Region: STN; smart00965
1218933002348	ferrichrome receptor precursor protein; Provisional; Region: PRK14050
1218933002349	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933002350	N-terminal plug; other site
1218933002351	ligand-binding site [chemical binding]; other site
1218933002352	RNA polymerase sigma factor; Provisional; Region: PRK12528
1218933002353	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1218933002354	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1218933002355	DNA binding residues [nucleotide binding]
1218933002356	fec operon regulator FecR; Reviewed; Region: PRK09774
1218933002357	FecR protein; Region: FecR; pfam04773
1218933002358	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1218933002359	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1218933002360	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1218933002361	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1218933002362	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1218933002363	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1218933002364	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
1218933002365	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1218933002366	homodimer interface [polypeptide binding]; other site
1218933002367	substrate-cofactor binding pocket; other site
1218933002368	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933002369	catalytic residue [active]
1218933002370	L,D-transpeptidase; Provisional; Region: PRK10260
1218933002371	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1218933002372	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1218933002373	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
1218933002374	putative active site [active]
1218933002375	catalytic triad [active]
1218933002376	putative dimer interface [polypeptide binding]; other site
1218933002377	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1218933002378	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
1218933002379	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1218933002380	dimer interface [polypeptide binding]; other site
1218933002381	PYR/PP interface [polypeptide binding]; other site
1218933002382	TPP binding site [chemical binding]; other site
1218933002383	substrate binding site [chemical binding]; other site
1218933002384	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1218933002385	Domain of unknown function; Region: EKR; pfam10371
1218933002386	4Fe-4S binding domain; Region: Fer4_6; pfam12837
1218933002387	4Fe-4S binding domain; Region: Fer4; pfam00037
1218933002388	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
1218933002389	TPP-binding site [chemical binding]; other site
1218933002390	dimer interface [polypeptide binding]; other site
1218933002391	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
1218933002392	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933002393	The C-terminal substrate biniding domain of an uncharacterized LysR-like transcriptional regulator Pa0477 related to DntR, contains the type 2 periplasmic binding fold; Region: PBP2_Pa0477; cd08468
1218933002394	putative substrate binding pocket [chemical binding]; other site
1218933002395	dimerization interface [polypeptide binding]; other site
1218933002396	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1218933002397	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933002398	Coenzyme A binding pocket [chemical binding]; other site
1218933002399	LysE type translocator; Region: LysE; cl00565
1218933002400	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1218933002401	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1218933002402	substrate binding pocket [chemical binding]; other site
1218933002403	membrane-bound complex binding site; other site
1218933002404	hinge residues; other site
1218933002405	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
1218933002406	Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547
1218933002407	Fic/DOC family; Region: Fic; cl00960
1218933002408	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1218933002409	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
1218933002410	putative coenzyme Q binding site [chemical binding]; other site
1218933002411	hypothetical protein; Validated; Region: PRK01777
1218933002412	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
1218933002413	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
1218933002414	recombination and repair protein; Provisional; Region: PRK10869
1218933002415	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1218933002416	Walker A/P-loop; other site
1218933002417	ATP binding site [chemical binding]; other site
1218933002418	Q-loop/lid; other site
1218933002419	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1218933002420	ABC transporter signature motif; other site
1218933002421	Walker B; other site
1218933002422	D-loop; other site
1218933002423	H-loop/switch region; other site
1218933002424	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
1218933002425	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
1218933002426	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
1218933002427	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1218933002428	dimer interface [polypeptide binding]; other site
1218933002429	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1218933002430	manganese transport protein MntH; Reviewed; Region: PRK00701
1218933002431	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1218933002432	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
1218933002433	active site 1 [active]
1218933002434	dimer interface [polypeptide binding]; other site
1218933002435	hexamer interface [polypeptide binding]; other site
1218933002436	active site 2 [active]
1218933002437	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
1218933002438	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933002439	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1218933002440	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
1218933002441	dimer interface [polypeptide binding]; other site
1218933002442	active site
1218933002443	metal binding site [ion binding]; metal-binding site
1218933002444	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
1218933002445	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1218933002446	dimer interface [polypeptide binding]; other site
1218933002447	ADP-ribose binding site [chemical binding]; other site
1218933002448	active site
1218933002449	nudix motif; other site
1218933002450	metal binding site [ion binding]; metal-binding site
1218933002451	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1218933002452	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1218933002453	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933002454	dimer interface [polypeptide binding]; other site
1218933002455	conserved gate region; other site
1218933002456	putative PBP binding loops; other site
1218933002457	ABC-ATPase subunit interface; other site
1218933002458	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1218933002459	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933002460	dimer interface [polypeptide binding]; other site
1218933002461	conserved gate region; other site
1218933002462	putative PBP binding loops; other site
1218933002463	ABC-ATPase subunit interface; other site
1218933002464	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1218933002465	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1218933002466	Walker A/P-loop; other site
1218933002467	ATP binding site [chemical binding]; other site
1218933002468	Q-loop/lid; other site
1218933002469	ABC transporter signature motif; other site
1218933002470	Walker B; other site
1218933002471	D-loop; other site
1218933002472	H-loop/switch region; other site
1218933002473	TOBE domain; Region: TOBE_2; pfam08402
1218933002474	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
1218933002475	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1218933002476	Ricin-type beta-trefoil; Region: RICIN; smart00458
1218933002477	putative sugar binding sites [chemical binding]; other site
1218933002478	Q-X-W motif; other site
1218933002479	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
1218933002480	putative dimerization interface [polypeptide binding]; other site
1218933002481	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1218933002482	putative ligand binding site [chemical binding]; other site
1218933002483	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1218933002484	CAT RNA binding domain; Region: CAT_RBD; smart01061
1218933002485	PRD domain; Region: PRD; pfam00874
1218933002486	PRD domain; Region: PRD; pfam00874
1218933002487	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1218933002488	beta-galactosidase; Region: BGL; TIGR03356
1218933002489	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
1218933002490	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1218933002491	active site turn [active]
1218933002492	phosphorylation site [posttranslational modification]
1218933002493	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1218933002494	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1218933002495	HPr interaction site; other site
1218933002496	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1218933002497	active site
1218933002498	phosphorylation site [posttranslational modification]
1218933002499	transketolase; Reviewed; Region: PRK12753
1218933002500	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1218933002501	TPP-binding site [chemical binding]; other site
1218933002502	dimer interface [polypeptide binding]; other site
1218933002503	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1218933002504	PYR/PP interface [polypeptide binding]; other site
1218933002505	dimer interface [polypeptide binding]; other site
1218933002506	TPP binding site [chemical binding]; other site
1218933002507	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1218933002508	transaldolase-like protein; Provisional; Region: PTZ00411
1218933002509	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
1218933002510	active site
1218933002511	dimer interface [polypeptide binding]; other site
1218933002512	catalytic residue [active]
1218933002513	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1218933002514	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933002515	D-galactonate transporter; Region: 2A0114; TIGR00893
1218933002516	putative substrate translocation pore; other site
1218933002517	dihydroxyacetone kinase; Provisional; Region: PRK14479
1218933002518	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
1218933002519	DAK2 domain; Region: Dak2; pfam02734
1218933002520	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1218933002521	substrate binding site [chemical binding]; other site
1218933002522	dimer interface [polypeptide binding]; other site
1218933002523	catalytic triad [active]
1218933002524	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1218933002525	prephenate dehydrogenase; Provisional; Region: PRK08655
1218933002526	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1218933002527	Homeodomain-like domain; Region: HTH_23; pfam13384
1218933002528	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1218933002529	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
1218933002530	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1218933002531	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1218933002532	putative NAD(P) binding site [chemical binding]; other site
1218933002533	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
1218933002534	tryptophan permease; Provisional; Region: PRK10483
1218933002535	aromatic amino acid transport protein; Region: araaP; TIGR00837
1218933002536	hypothetical protein; Validated; Region: PRK00124
1218933002537	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
1218933002538	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
1218933002539	putative acetyltransferase; Provisional; Region: PRK03624
1218933002540	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933002541	Coenzyme A binding pocket [chemical binding]; other site
1218933002542	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1218933002543	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
1218933002544	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1218933002545	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1218933002546	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1218933002547	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1218933002548	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1218933002549	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
1218933002550	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
1218933002551	Protein of unknown function (DUF1131); Region: DUF1131; pfam06572
1218933002552	RpoE-regulated lipoprotein; Provisional; Region: PRK10718
1218933002553	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
1218933002554	thiosulfate transporter subunit; Provisional; Region: PRK10852
1218933002555	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1218933002556	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1218933002557	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933002558	dimer interface [polypeptide binding]; other site
1218933002559	conserved gate region; other site
1218933002560	putative PBP binding loops; other site
1218933002561	ABC-ATPase subunit interface; other site
1218933002562	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1218933002563	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933002564	dimer interface [polypeptide binding]; other site
1218933002565	conserved gate region; other site
1218933002566	putative PBP binding loops; other site
1218933002567	ABC-ATPase subunit interface; other site
1218933002568	cysteine synthase B; Region: cysM; TIGR01138
1218933002569	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1218933002570	dimer interface [polypeptide binding]; other site
1218933002571	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933002572	catalytic residue [active]
1218933002573	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
1218933002574	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1218933002575	Walker A/P-loop; other site
1218933002576	ATP binding site [chemical binding]; other site
1218933002577	Q-loop/lid; other site
1218933002578	ABC transporter signature motif; other site
1218933002579	Walker B; other site
1218933002580	D-loop; other site
1218933002581	H-loop/switch region; other site
1218933002582	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1218933002583	FtsX-like permease family; Region: FtsX; pfam02687
1218933002584	macrolide transporter subunit MacA; Provisional; Region: PRK11578
1218933002585	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1218933002586	HlyD family secretion protein; Region: HlyD_3; pfam13437
1218933002587	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1218933002588	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933002589	active site
1218933002590	phosphorylation site [posttranslational modification]
1218933002591	intermolecular recognition site; other site
1218933002592	dimerization interface [polypeptide binding]; other site
1218933002593	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1218933002594	DNA binding site [nucleotide binding]
1218933002595	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1218933002596	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933002597	dimerization interface [polypeptide binding]; other site
1218933002598	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1218933002599	dimer interface [polypeptide binding]; other site
1218933002600	phosphorylation site [posttranslational modification]
1218933002601	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933002602	ATP binding site [chemical binding]; other site
1218933002603	Mg2+ binding site [ion binding]; other site
1218933002604	G-X-G motif; other site
1218933002605	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1218933002606	HPr interaction site; other site
1218933002607	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1218933002608	active site
1218933002609	phosphorylation site [posttranslational modification]
1218933002610	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
1218933002611	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1218933002612	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1218933002613	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1218933002614	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1218933002615	dimerization domain swap beta strand [polypeptide binding]; other site
1218933002616	regulatory protein interface [polypeptide binding]; other site
1218933002617	active site
1218933002618	regulatory phosphorylation site [posttranslational modification]; other site
1218933002619	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1218933002620	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1218933002621	dimer interface [polypeptide binding]; other site
1218933002622	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933002623	catalytic residue [active]
1218933002624	putative sulfate transport protein CysZ; Validated; Region: PRK04949
1218933002625	cell division protein ZipA; Provisional; Region: PRK03427
1218933002626	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
1218933002627	FtsZ protein binding site [polypeptide binding]; other site
1218933002628	putative transporter; Provisional; Region: PRK11021
1218933002629	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
1218933002630	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
1218933002631	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
1218933002632	tellurite resistance protein TehB; Provisional; Region: PRK12335
1218933002633	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
1218933002634	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933002635	S-adenosylmethionine binding site [chemical binding]; other site
1218933002636	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
1218933002637	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1218933002638	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1218933002639	anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452
1218933002640	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1218933002641	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1218933002642	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1218933002643	iron binding site [ion binding]; other site
1218933002644	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
1218933002645	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1218933002646	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933002647	Walker A motif; other site
1218933002648	ATP binding site [chemical binding]; other site
1218933002649	Walker B motif; other site
1218933002650	arginine finger; other site
1218933002651	fumarate hydratase; Provisional; Region: PRK15389
1218933002652	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
1218933002653	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1218933002654	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1218933002655	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1218933002656	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1218933002657	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933002658	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933002659	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1218933002660	dimerization interface [polypeptide binding]; other site
1218933002661	Predicted membrane protein [Function unknown]; Region: COG4125
1218933002662	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
1218933002663	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
1218933002664	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1218933002665	endonuclease III; Region: ENDO3c; smart00478
1218933002666	minor groove reading motif; other site
1218933002667	helix-hairpin-helix signature motif; other site
1218933002668	substrate binding pocket [chemical binding]; other site
1218933002669	active site
1218933002670	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1218933002671	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
1218933002672	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1218933002673	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933002674	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1218933002675	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1218933002676	DNA binding site [nucleotide binding]
1218933002677	active site
1218933002678	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
1218933002679	hypothetical protein; Validated; Region: PRK07121
1218933002680	Predicted oxidoreductase [General function prediction only]; Region: COG3573
1218933002681	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1218933002682	FMN-binding domain; Region: FMN_bind; pfam04205
1218933002683	putative transporter; Provisional; Region: PRK10504
1218933002684	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933002685	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
1218933002686	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
1218933002687	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1218933002688	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1218933002689	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1218933002690	substrate binding pocket [chemical binding]; other site
1218933002691	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1218933002692	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933002693	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933002694	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1218933002695	dimerization interface [polypeptide binding]; other site
1218933002696	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
1218933002697	Uncharacterized conserved protein [Function unknown]; Region: COG4104
1218933002698	S-type Pyocin; Region: Pyocin_S; pfam06958
1218933002699	DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639
1218933002700	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
1218933002701	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
1218933002702	putative active site pocket [active]
1218933002703	putative metal binding site [ion binding]; other site
1218933002704	putative oxidoreductase; Provisional; Region: PRK10083
1218933002705	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
1218933002706	putative NAD(P) binding site [chemical binding]; other site
1218933002707	catalytic Zn binding site [ion binding]; other site
1218933002708	structural Zn binding site [ion binding]; other site
1218933002709	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933002710	metabolite-proton symporter; Region: 2A0106; TIGR00883
1218933002711	putative substrate translocation pore; other site
1218933002712	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1218933002713	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1218933002714	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1218933002715	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1218933002716	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933002717	DNA-binding site [nucleotide binding]; DNA binding site
1218933002718	FCD domain; Region: FCD; pfam07729
1218933002719	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
1218933002720	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1218933002721	PLD-like domain; Region: PLDc_2; pfam13091
1218933002722	putative active site [active]
1218933002723	catalytic site [active]
1218933002724	Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107
1218933002725	PLD-like domain; Region: PLDc_2; pfam13091
1218933002726	putative active site [active]
1218933002727	putative catalytic site [active]
1218933002728	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1218933002729	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1218933002730	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1218933002731	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933002732	Gram-negative bacterial tonB protein; Region: TonB; cl10048
1218933002733	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1218933002734	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1218933002735	drug efflux system protein MdtG; Provisional; Region: PRK09874
1218933002736	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933002737	putative substrate translocation pore; other site
1218933002738	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
1218933002739	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1218933002740	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1218933002741	Na binding site [ion binding]; other site
1218933002742	PAS fold; Region: PAS_4; pfam08448
1218933002743	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1218933002744	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1218933002745	DNA binding residues [nucleotide binding]
1218933002746	dimerization interface [polypeptide binding]; other site
1218933002747	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933002748	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933002749	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
1218933002750	Predicted permeases [General function prediction only]; Region: COG0679
1218933002751	ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003
1218933002752	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933002753	N-terminal plug; other site
1218933002754	ligand-binding site [chemical binding]; other site
1218933002755	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
1218933002756	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
1218933002757	active site
1218933002758	tetramer interface [polypeptide binding]; other site
1218933002759	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1218933002760	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933002761	putative substrate translocation pore; other site
1218933002762	Predicted ATPase [General function prediction only]; Region: COG3910
1218933002763	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
1218933002764	Walker A/P-loop; other site
1218933002765	ATP binding site [chemical binding]; other site
1218933002766	Q-loop/lid; other site
1218933002767	ABC transporter signature motif; other site
1218933002768	Walker B; other site
1218933002769	D-loop; other site
1218933002770	H-loop/switch region; other site
1218933002771	Protein of unknown function (DUF2569); Region: DUF2569; pfam10754
1218933002772	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1218933002773	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1218933002774	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1218933002775	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1218933002776	putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284
1218933002777	PapC N-terminal domain; Region: PapC_N; pfam13954
1218933002778	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1218933002779	PapC C-terminal domain; Region: PapC_C; pfam13953
1218933002780	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1218933002781	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
1218933002782	DNA binding site [nucleotide binding]
1218933002783	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1218933002784	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1218933002785	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1218933002786	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1218933002787	ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748
1218933002788	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
1218933002789	putative dimer interface [polypeptide binding]; other site
1218933002790	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1218933002791	ligand binding site [chemical binding]; other site
1218933002792	Zn binding site [ion binding]; other site
1218933002793	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1218933002794	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1218933002795	HPP family; Region: HPP; pfam04982
1218933002796	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1218933002797	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1218933002798	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1218933002799	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1218933002800	O-methyltransferase; Region: Methyltransf_2; pfam00891
1218933002801	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1218933002802	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1218933002803	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1218933002804	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1218933002805	MarR family; Region: MarR; pfam01047
1218933002806	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
1218933002807	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933002808	putative substrate translocation pore; other site
1218933002809	Cupin; Region: Cupin_6; pfam12852
1218933002810	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933002811	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1218933002812	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933002813	Protein of unknown function (DUF1778); Region: DUF1778; cl01845
1218933002814	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
1218933002815	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1218933002816	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
1218933002817	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
1218933002818	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1218933002819	SLBB domain; Region: SLBB; pfam10531
1218933002820	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
1218933002821	Chain length determinant protein; Region: Wzz; pfam02706
1218933002822	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1218933002823	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1218933002824	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
1218933002825	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1218933002826	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1218933002827	active site
1218933002828	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1218933002829	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1218933002830	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1218933002831	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1218933002832	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
1218933002833	putative acyl transferase; Provisional; Region: PRK10191
1218933002834	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1218933002835	trimer interface [polypeptide binding]; other site
1218933002836	active site
1218933002837	substrate binding site [chemical binding]; other site
1218933002838	CoA binding site [chemical binding]; other site
1218933002839	HTH-like domain; Region: HTH_21; pfam13276
1218933002840	Transposase; Region: HTH_Tnp_1; pfam01527
1218933002841	CVNH domain; Region: CVNH; pfam08881
1218933002842	Post-segregation antitoxin CcdA; Region: CcdA; cl02188
1218933002843	ornithine decarboxylase; Provisional; Region: PRK13578
1218933002844	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
1218933002845	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1218933002846	homodimer interface [polypeptide binding]; other site
1218933002847	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933002848	catalytic residue [active]
1218933002849	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1218933002850	L-asparagine permease; Provisional; Region: PRK15049
1218933002851	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1218933002852	classical (c) SDRs; Region: SDR_c; cd05233
1218933002853	NAD(P) binding site [chemical binding]; other site
1218933002854	active site
1218933002855	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1218933002856	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1218933002857	hypothetical protein; Provisional; Region: PRK02399
1218933002858	Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792
1218933002859	TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370
1218933002860	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1218933002861	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1218933002862	Helix-turn-helix domain; Region: HTH_18; pfam12833
1218933002863	murein transglycosylase C; Provisional; Region: mltC; PRK11671
1218933002864	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
1218933002865	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1218933002866	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1218933002867	catalytic residue [active]
1218933002868	oxidative damage protection protein; Provisional; Region: PRK05408
1218933002869	adenine DNA glycosylase; Provisional; Region: PRK10880
1218933002870	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1218933002871	minor groove reading motif; other site
1218933002872	helix-hairpin-helix signature motif; other site
1218933002873	substrate binding pocket [chemical binding]; other site
1218933002874	active site
1218933002875	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1218933002876	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1218933002877	DNA binding and oxoG recognition site [nucleotide binding]
1218933002878	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
1218933002879	hypothetical protein; Provisional; Region: PRK11702
1218933002880	hypothetical protein; Provisional; Region: PRK10626
1218933002881	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
1218933002882	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
1218933002883	catalytic triad [active]
1218933002884	putative active site [active]
1218933002885	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
1218933002886	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
1218933002887	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1218933002888	phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079
1218933002889	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933002890	DNA-binding site [nucleotide binding]; DNA binding site
1218933002891	UTRA domain; Region: UTRA; pfam07702
1218933002892	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
1218933002893	carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147
1218933002894	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
1218933002895	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627
1218933002896	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
1218933002897	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933002898	Walker A/P-loop; other site
1218933002899	ATP binding site [chemical binding]; other site
1218933002900	Q-loop/lid; other site
1218933002901	ABC transporter signature motif; other site
1218933002902	Walker B; other site
1218933002903	D-loop; other site
1218933002904	H-loop/switch region; other site
1218933002905	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1218933002906	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
1218933002907	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933002908	Walker A/P-loop; other site
1218933002909	ATP binding site [chemical binding]; other site
1218933002910	Q-loop/lid; other site
1218933002911	ABC transporter signature motif; other site
1218933002912	Walker B; other site
1218933002913	D-loop; other site
1218933002914	H-loop/switch region; other site
1218933002915	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
1218933002916	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
1218933002917	active site
1218933002918	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1218933002919	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1218933002920	Walker A/P-loop; other site
1218933002921	ATP binding site [chemical binding]; other site
1218933002922	Q-loop/lid; other site
1218933002923	ABC transporter signature motif; other site
1218933002924	Walker B; other site
1218933002925	D-loop; other site
1218933002926	H-loop/switch region; other site
1218933002927	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
1218933002928	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1218933002929	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1218933002930	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933002931	dimer interface [polypeptide binding]; other site
1218933002932	conserved gate region; other site
1218933002933	putative PBP binding loops; other site
1218933002934	ABC-ATPase subunit interface; other site
1218933002935	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1218933002936	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1218933002937	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1218933002938	active site
1218933002939	catalytic tetrad [active]
1218933002940	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
1218933002941	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1218933002942	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
1218933002943	putative DNA-binding cleft [nucleotide binding]; other site
1218933002944	putative DNA clevage site; other site
1218933002945	molecular lever; other site
1218933002946	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
1218933002947	putative active site [active]
1218933002948	Ap4A binding site [chemical binding]; other site
1218933002949	nudix motif; other site
1218933002950	putative metal binding site [ion binding]; other site
1218933002951	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
1218933002952	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1218933002953	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1218933002954	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1218933002955	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1218933002956	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1218933002957	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1218933002958	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1218933002959	dimerization interface [polypeptide binding]; other site
1218933002960	active site
1218933002961	hypothetical protein; Provisional; Region: PRK10506
1218933002962	hypothetical protein; Provisional; Region: PRK10557
1218933002963	Protein of unknown function (DUF2509); Region: DUF2509; pfam10713
1218933002964	hypothetical protein; Provisional; Region: PRK10332
1218933002965	Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528
1218933002966	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
1218933002967	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
1218933002968	protease3; Provisional; Region: PRK15101
1218933002969	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1218933002970	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1218933002971	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1218933002972	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
1218933002973	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1218933002974	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
1218933002975	AAA domain; Region: AAA_30; pfam13604
1218933002976	Family description; Region: UvrD_C_2; pfam13538
1218933002977	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1218933002978	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1218933002979	DNA binding site [nucleotide binding]
1218933002980	domain linker motif; other site
1218933002981	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1218933002982	putative dimerization interface [polypeptide binding]; other site
1218933002983	putative ligand binding site [chemical binding]; other site
1218933002984	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1218933002985	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1218933002986	active site pocket [active]
1218933002987	N-acetylglutamate synthase; Validated; Region: PRK05279
1218933002988	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
1218933002989	putative feedback inhibition sensing region; other site
1218933002990	putative nucleotide binding site [chemical binding]; other site
1218933002991	putative substrate binding site [chemical binding]; other site
1218933002992	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933002993	Coenzyme A binding pocket [chemical binding]; other site
1218933002994	AMIN domain; Region: AMIN; pfam11741
1218933002995	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1218933002996	active site
1218933002997	metal binding site [ion binding]; metal-binding site
1218933002998	murein transglycosylase A; Provisional; Region: mltA; PRK11162
1218933002999	MltA specific insert domain; Region: MltA; smart00925
1218933003000	3D domain; Region: 3D; pfam06725
1218933003001	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1218933003002	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1218933003003	dimer interface [polypeptide binding]; other site
1218933003004	active site
1218933003005	catalytic residue [active]
1218933003006	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1218933003007	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1218933003008	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1218933003009	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1218933003010	metal binding site [ion binding]; metal-binding site
1218933003011	putative dimer interface [polypeptide binding]; other site
1218933003012	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1218933003013	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933003014	Walker A/P-loop; other site
1218933003015	ATP binding site [chemical binding]; other site
1218933003016	Q-loop/lid; other site
1218933003017	ABC transporter signature motif; other site
1218933003018	Walker B; other site
1218933003019	D-loop; other site
1218933003020	H-loop/switch region; other site
1218933003021	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933003022	Walker A/P-loop; other site
1218933003023	ATP binding site [chemical binding]; other site
1218933003024	Q-loop/lid; other site
1218933003025	ABC transporter signature motif; other site
1218933003026	Walker B; other site
1218933003027	D-loop; other site
1218933003028	H-loop/switch region; other site
1218933003029	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1218933003030	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1218933003031	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1218933003032	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933003033	dimer interface [polypeptide binding]; other site
1218933003034	conserved gate region; other site
1218933003035	putative PBP binding loops; other site
1218933003036	ABC-ATPase subunit interface; other site
1218933003037	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1218933003038	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933003039	dimer interface [polypeptide binding]; other site
1218933003040	conserved gate region; other site
1218933003041	putative PBP binding loops; other site
1218933003042	ABC-ATPase subunit interface; other site
1218933003043	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1218933003044	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
1218933003045	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
1218933003046	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
1218933003047	molybdopterin cofactor binding site [chemical binding]; other site
1218933003048	substrate binding site [chemical binding]; other site
1218933003049	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
1218933003050	molybdopterin cofactor binding site; other site
1218933003051	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
1218933003052	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1218933003053	putative ATP binding site [chemical binding]; other site
1218933003054	putative substrate interface [chemical binding]; other site
1218933003055	Fe-S metabolism associated domain; Region: SufE; cl00951
1218933003056	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1218933003057	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1218933003058	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1218933003059	catalytic residue [active]
1218933003060	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
1218933003061	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1218933003062	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933003063	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1218933003064	dimerization interface [polypeptide binding]; other site
1218933003065	substrate binding pocket [chemical binding]; other site
1218933003066	hypothetical protein; Provisional; Region: PRK10873
1218933003067	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
1218933003068	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1218933003069	flap endonuclease-like protein; Provisional; Region: PRK09482
1218933003070	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1218933003071	active site
1218933003072	metal binding site 1 [ion binding]; metal-binding site
1218933003073	putative 5' ssDNA interaction site; other site
1218933003074	metal binding site 3; metal-binding site
1218933003075	metal binding site 2 [ion binding]; metal-binding site
1218933003076	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1218933003077	putative DNA binding site [nucleotide binding]; other site
1218933003078	putative metal binding site [ion binding]; other site
1218933003079	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1218933003080	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
1218933003081	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
1218933003082	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
1218933003083	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
1218933003084	SecY interacting protein Syd; Provisional; Region: PRK04968
1218933003085	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1218933003086	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1218933003087	active site
1218933003088	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1218933003089	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1218933003090	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
1218933003091	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
1218933003092	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1218933003093	probable active site [active]
1218933003094	flavodoxin; Provisional; Region: PRK08105
1218933003095	hypothetical protein; Provisional; Region: PRK13677
1218933003096	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
1218933003097	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1218933003098	trimer interface [polypeptide binding]; other site
1218933003099	active site
1218933003100	substrate binding site [chemical binding]; other site
1218933003101	CoA binding site [chemical binding]; other site
1218933003102	PII uridylyl-transferase; Provisional; Region: PRK05007
1218933003103	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1218933003104	metal binding triad; other site
1218933003105	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1218933003106	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
1218933003107	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
1218933003108	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
1218933003109	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1218933003110	active site
1218933003111	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1218933003112	rRNA interaction site [nucleotide binding]; other site
1218933003113	S8 interaction site; other site
1218933003114	putative laminin-1 binding site; other site
1218933003115	elongation factor Ts; Provisional; Region: tsf; PRK09377
1218933003116	UBA/TS-N domain; Region: UBA; pfam00627
1218933003117	Elongation factor TS; Region: EF_TS; pfam00889
1218933003118	Elongation factor TS; Region: EF_TS; pfam00889
1218933003119	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1218933003120	putative nucleotide binding site [chemical binding]; other site
1218933003121	uridine monophosphate binding site [chemical binding]; other site
1218933003122	homohexameric interface [polypeptide binding]; other site
1218933003123	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1218933003124	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1218933003125	hinge region; other site
1218933003126	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1218933003127	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1218933003128	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1218933003129	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1218933003130	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1218933003131	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1218933003132	catalytic residue [active]
1218933003133	putative FPP diphosphate  binding site; other site
1218933003134	putative FPP binding hydrophobic cleft; other site
1218933003135	dimer interface [polypeptide binding]; other site
1218933003136	putative IPP diphosphate binding site; other site
1218933003137	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
1218933003138	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1218933003139	zinc metallopeptidase RseP; Provisional; Region: PRK10779
1218933003140	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1218933003141	active site
1218933003142	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1218933003143	protein binding site [polypeptide binding]; other site
1218933003144	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1218933003145	protein binding site [polypeptide binding]; other site
1218933003146	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1218933003147	putative substrate binding region [chemical binding]; other site
1218933003148	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
1218933003149	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1218933003150	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1218933003151	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1218933003152	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1218933003153	Surface antigen; Region: Bac_surface_Ag; pfam01103
1218933003154	periplasmic chaperone; Provisional; Region: PRK10780
1218933003155	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
1218933003156	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1218933003157	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1218933003158	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1218933003159	trimer interface [polypeptide binding]; other site
1218933003160	active site
1218933003161	UDP-GlcNAc binding site [chemical binding]; other site
1218933003162	lipid binding site [chemical binding]; lipid-binding site
1218933003163	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1218933003164	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1218933003165	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1218933003166	active site
1218933003167	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
1218933003168	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1218933003169	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1218933003170	RNA/DNA hybrid binding site [nucleotide binding]; other site
1218933003171	active site
1218933003172	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1218933003173	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
1218933003174	putative active site [active]
1218933003175	putative PHP Thumb interface [polypeptide binding]; other site
1218933003176	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1218933003177	generic binding surface II; other site
1218933003178	generic binding surface I; other site
1218933003179	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1218933003180	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1218933003181	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
1218933003182	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1218933003183	putative metal binding site [ion binding]; other site
1218933003184	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
1218933003185	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1218933003186	Ligand Binding Site [chemical binding]; other site
1218933003187	TilS substrate binding domain; Region: TilS; pfam09179
1218933003188	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
1218933003189	Rho-binding antiterminator; Provisional; Region: PRK11625
1218933003190	hypothetical protein; Provisional; Region: PRK04964
1218933003191	YaeQ protein; Region: YaeQ; pfam07152
1218933003192	lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523
1218933003193	NlpE N-terminal domain; Region: NlpE; pfam04170
1218933003194	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1218933003195	MutS domain I; Region: MutS_I; pfam01624
1218933003196	MutS domain II; Region: MutS_II; pfam05188
1218933003197	MutS domain III; Region: MutS_III; pfam05192
1218933003198	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1218933003199	Walker A/P-loop; other site
1218933003200	ATP binding site [chemical binding]; other site
1218933003201	Q-loop/lid; other site
1218933003202	ABC transporter signature motif; other site
1218933003203	Walker B; other site
1218933003204	D-loop; other site
1218933003205	H-loop/switch region; other site
1218933003206	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
1218933003207	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1218933003208	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1218933003209	putative C-terminal domain interface [polypeptide binding]; other site
1218933003210	putative GSH binding site (G-site) [chemical binding]; other site
1218933003211	putative dimer interface [polypeptide binding]; other site
1218933003212	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
1218933003213	putative N-terminal domain interface [polypeptide binding]; other site
1218933003214	putative dimer interface [polypeptide binding]; other site
1218933003215	putative substrate binding pocket (H-site) [chemical binding]; other site
1218933003216	iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231
1218933003217	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1218933003218	Walker A/P-loop; other site
1218933003219	ATP binding site [chemical binding]; other site
1218933003220	Q-loop/lid; other site
1218933003221	ABC transporter signature motif; other site
1218933003222	Walker B; other site
1218933003223	D-loop; other site
1218933003224	H-loop/switch region; other site
1218933003225	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1218933003226	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1218933003227	ABC-ATPase subunit  interface; other site
1218933003228	dimer interface [polypeptide binding]; other site
1218933003229	putative PBP binding regions; other site
1218933003230	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1218933003231	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1218933003232	ABC-ATPase subunit  interface; other site
1218933003233	dimer interface [polypeptide binding]; other site
1218933003234	putative PBP binding regions; other site
1218933003235	iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411
1218933003236	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1218933003237	siderophore binding site; other site
1218933003238	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
1218933003239	Secretin and TonB N terminus short domain; Region: STN; smart00965
1218933003240	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933003241	N-terminal plug; other site
1218933003242	ligand-binding site [chemical binding]; other site
1218933003243	fec operon regulator FecR; Reviewed; Region: PRK09774
1218933003244	FecR protein; Region: FecR; pfam04773
1218933003245	RNA polymerase sigma factor FecI; Provisional; Region: PRK09651
1218933003246	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1218933003247	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1218933003248	DNA binding residues [nucleotide binding]
1218933003249	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1218933003250	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
1218933003251	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1218933003252	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1218933003253	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1218933003254	PhnA protein; Region: PhnA; pfam03831
1218933003255	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1218933003256	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1218933003257	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1218933003258	catalytic residue [active]
1218933003259	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1218933003260	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933003261	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933003262	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
1218933003263	putative dimerization interface [polypeptide binding]; other site
1218933003264	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1218933003265	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1218933003266	metal binding site [ion binding]; metal-binding site
1218933003267	active site
1218933003268	I-site; other site
1218933003269	Domain of unknown function (DUF1987); Region: DUF1987; pfam09345
1218933003270	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
1218933003271	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1218933003272	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1218933003273	Esterase/lipase [General function prediction only]; Region: COG1647
1218933003274	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
1218933003275	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933003276	DNA-binding site [nucleotide binding]; DNA binding site
1218933003277	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1218933003278	mannonate dehydratase; Provisional; Region: PRK03906
1218933003279	mannonate dehydratase; Region: uxuA; TIGR00695
1218933003280	Pectate lyase; Region: Pectate_lyase; pfam03211
1218933003281	Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295
1218933003282	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
1218933003283	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1218933003284	HlyD family secretion protein; Region: HlyD_3; pfam13437
1218933003285	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
1218933003286	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1218933003287	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
1218933003288	Walker A/P-loop; other site
1218933003289	ATP binding site [chemical binding]; other site
1218933003290	Q-loop/lid; other site
1218933003291	ABC transporter signature motif; other site
1218933003292	Walker B; other site
1218933003293	D-loop; other site
1218933003294	H-loop/switch region; other site
1218933003295	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1218933003296	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933003297	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1218933003298	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1218933003299	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1218933003300	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933003301	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1218933003302	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933003303	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1218933003304	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933003305	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1218933003306	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933003307	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1218933003308	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1218933003309	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933003310	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1218933003311	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933003312	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1218933003313	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1218933003314	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933003315	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1218933003316	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933003317	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1218933003318	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933003319	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1218933003320	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933003321	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1218933003322	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933003323	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933003324	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933003325	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1218933003326	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
1218933003327	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1218933003328	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933003329	Walker A/P-loop; other site
1218933003330	ATP binding site [chemical binding]; other site
1218933003331	Q-loop/lid; other site
1218933003332	ABC transporter signature motif; other site
1218933003333	Walker B; other site
1218933003334	D-loop; other site
1218933003335	H-loop/switch region; other site
1218933003336	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1218933003337	active site
1218933003338	homodimer interface [polypeptide binding]; other site
1218933003339	homotetramer interface [polypeptide binding]; other site
1218933003340	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
1218933003341	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1218933003342	ADP binding site [chemical binding]; other site
1218933003343	magnesium binding site [ion binding]; other site
1218933003344	putative shikimate binding site; other site
1218933003345	hypothetical protein; Provisional; Region: PRK10579
1218933003346	nucleoside transporter; Region: 2A0110; TIGR00889
1218933003347	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933003348	putative substrate translocation pore; other site
1218933003349	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
1218933003350	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1218933003351	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1218933003352	substrate binding site [chemical binding]; other site
1218933003353	ATP binding site [chemical binding]; other site
1218933003354	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1218933003355	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933003356	DNA-binding site [nucleotide binding]; DNA binding site
1218933003357	UTRA domain; Region: UTRA; pfam07702
1218933003358	Cache domain; Region: Cache_1; pfam02743
1218933003359	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1218933003360	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933003361	dimerization interface [polypeptide binding]; other site
1218933003362	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933003363	dimer interface [polypeptide binding]; other site
1218933003364	putative CheW interface [polypeptide binding]; other site
1218933003365	recombination associated protein; Reviewed; Region: rdgC; PRK00321
1218933003366	fructokinase; Reviewed; Region: PRK09557
1218933003367	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1218933003368	nucleotide binding site [chemical binding]; other site
1218933003369	Acetokinase family; Region: Acetate_kinase; cl17229
1218933003370	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933003371	AAA domain; Region: AAA_23; pfam13476
1218933003372	Walker A/P-loop; other site
1218933003373	ATP binding site [chemical binding]; other site
1218933003374	Q-loop/lid; other site
1218933003375	exonuclease subunit SbcC; Provisional; Region: PRK10246
1218933003376	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933003377	Q-loop/lid; other site
1218933003378	ABC transporter signature motif; other site
1218933003379	Walker B; other site
1218933003380	D-loop; other site
1218933003381	H-loop/switch region; other site
1218933003382	exonuclease subunit SbcD; Provisional; Region: PRK10966
1218933003383	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1218933003384	active site
1218933003385	metal binding site [ion binding]; metal-binding site
1218933003386	DNA binding site [nucleotide binding]
1218933003387	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1218933003388	transcriptional regulator PhoB; Provisional; Region: PRK10161
1218933003389	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933003390	active site
1218933003391	phosphorylation site [posttranslational modification]
1218933003392	intermolecular recognition site; other site
1218933003393	dimerization interface [polypeptide binding]; other site
1218933003394	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1218933003395	DNA binding site [nucleotide binding]
1218933003396	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
1218933003397	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
1218933003398	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1218933003399	putative active site [active]
1218933003400	heme pocket [chemical binding]; other site
1218933003401	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1218933003402	dimer interface [polypeptide binding]; other site
1218933003403	phosphorylation site [posttranslational modification]
1218933003404	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437
1218933003405	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933003406	ATP binding site [chemical binding]; other site
1218933003407	Mg2+ binding site [ion binding]; other site
1218933003408	G-X-G motif; other site
1218933003409	PBP superfamily domain; Region: PBP_like_2; cl17296
1218933003410	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1218933003411	substrate binding site [chemical binding]; other site
1218933003412	THF binding site; other site
1218933003413	zinc-binding site [ion binding]; other site
1218933003414	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
1218933003415	putative proline-specific permease; Provisional; Region: proY; PRK10580
1218933003416	Spore germination protein; Region: Spore_permease; cl17796
1218933003417	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1218933003418	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1218933003419	peroxidase; Provisional; Region: PRK15000
1218933003420	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1218933003421	dimer interface [polypeptide binding]; other site
1218933003422	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1218933003423	catalytic triad [active]
1218933003424	peroxidatic and resolving cysteines [active]
1218933003425	Protein of unknown function, DUF479; Region: DUF479; cl01203
1218933003426	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1218933003427	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1218933003428	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1218933003429	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1218933003430	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
1218933003431	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
1218933003432	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1218933003433	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1218933003434	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1218933003435	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1218933003436	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1218933003437	Protein export membrane protein; Region: SecD_SecF; pfam02355
1218933003438	hypothetical protein; Provisional; Region: PRK11530
1218933003439	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1218933003440	ATP cone domain; Region: ATP-cone; pfam03477
1218933003441	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
1218933003442	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1218933003443	catalytic motif [active]
1218933003444	Zn binding site [ion binding]; other site
1218933003445	RibD C-terminal domain; Region: RibD_C; cl17279
1218933003446	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1218933003447	homopentamer interface [polypeptide binding]; other site
1218933003448	active site
1218933003449	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
1218933003450	putative RNA binding site [nucleotide binding]; other site
1218933003451	thiamine monophosphate kinase; Provisional; Region: PRK05731
1218933003452	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1218933003453	ATP binding site [chemical binding]; other site
1218933003454	dimerization interface [polypeptide binding]; other site
1218933003455	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1218933003456	tetramer interfaces [polypeptide binding]; other site
1218933003457	binuclear metal-binding site [ion binding]; other site
1218933003458	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1218933003459	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1218933003460	TPP-binding site; other site
1218933003461	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1218933003462	PYR/PP interface [polypeptide binding]; other site
1218933003463	dimer interface [polypeptide binding]; other site
1218933003464	TPP binding site [chemical binding]; other site
1218933003465	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1218933003466	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1218933003467	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1218933003468	substrate binding pocket [chemical binding]; other site
1218933003469	chain length determination region; other site
1218933003470	substrate-Mg2+ binding site; other site
1218933003471	catalytic residues [active]
1218933003472	aspartate-rich region 1; other site
1218933003473	active site lid residues [active]
1218933003474	aspartate-rich region 2; other site
1218933003475	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1218933003476	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
1218933003477	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1218933003478	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1218933003479	Ligand Binding Site [chemical binding]; other site
1218933003480	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1218933003481	active site residue [active]
1218933003482	oxidative-stress-resistance chaperone; Provisional; Region: PRK11574
1218933003483	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
1218933003484	conserved cys residue [active]
1218933003485	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1218933003486	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1218933003487	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1218933003488	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1218933003489	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1218933003490	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933003491	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1218933003492	putative substrate translocation pore; other site
1218933003493	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
1218933003494	UbiA prenyltransferase family; Region: UbiA; pfam01040
1218933003495	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
1218933003496	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1218933003497	Subunit I/III interface [polypeptide binding]; other site
1218933003498	Subunit III/IV interface [polypeptide binding]; other site
1218933003499	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1218933003500	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1218933003501	D-pathway; other site
1218933003502	Putative ubiquinol binding site [chemical binding]; other site
1218933003503	Low-spin heme (heme b) binding site [chemical binding]; other site
1218933003504	Putative water exit pathway; other site
1218933003505	Binuclear center (heme o3/CuB) [ion binding]; other site
1218933003506	K-pathway; other site
1218933003507	Putative proton exit pathway; other site
1218933003508	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
1218933003509	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1218933003510	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1218933003511	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933003512	muropeptide transporter; Reviewed; Region: ampG; PRK11902
1218933003513	putative substrate translocation pore; other site
1218933003514	hypothetical protein; Provisional; Region: PRK11627
1218933003515	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
1218933003516	transcriptional regulator BolA; Provisional; Region: PRK11628
1218933003517	trigger factor; Provisional; Region: tig; PRK01490
1218933003518	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1218933003519	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1218933003520	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1218933003521	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1218933003522	oligomer interface [polypeptide binding]; other site
1218933003523	active site residues [active]
1218933003524	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1218933003525	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1218933003526	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933003527	Walker A motif; other site
1218933003528	ATP binding site [chemical binding]; other site
1218933003529	Walker B motif; other site
1218933003530	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1218933003531	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
1218933003532	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1218933003533	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1218933003534	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933003535	Walker A motif; other site
1218933003536	ATP binding site [chemical binding]; other site
1218933003537	Walker B motif; other site
1218933003538	arginine finger; other site
1218933003539	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1218933003540	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1218933003541	IHF dimer interface [polypeptide binding]; other site
1218933003542	IHF - DNA interface [nucleotide binding]; other site
1218933003543	periplasmic folding chaperone; Provisional; Region: PRK10788
1218933003544	SurA N-terminal domain; Region: SurA_N_3; cl07813
1218933003545	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
1218933003546	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
1218933003547	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1218933003548	active site
1218933003549	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1218933003550	Ligand Binding Site [chemical binding]; other site
1218933003551	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1218933003552	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1218933003553	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1218933003554	catalytic residue [active]
1218933003555	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1218933003556	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1218933003557	putative DNA binding site [nucleotide binding]; other site
1218933003558	putative Zn2+ binding site [ion binding]; other site
1218933003559	AsnC family; Region: AsnC_trans_reg; pfam01037
1218933003560	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1218933003561	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1218933003562	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933003563	Walker A/P-loop; other site
1218933003564	ATP binding site [chemical binding]; other site
1218933003565	Q-loop/lid; other site
1218933003566	ABC transporter signature motif; other site
1218933003567	Walker B; other site
1218933003568	D-loop; other site
1218933003569	H-loop/switch region; other site
1218933003570	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
1218933003571	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1218933003572	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1218933003573	Walker A/P-loop; other site
1218933003574	ATP binding site [chemical binding]; other site
1218933003575	Q-loop/lid; other site
1218933003576	ABC transporter signature motif; other site
1218933003577	Walker B; other site
1218933003578	D-loop; other site
1218933003579	H-loop/switch region; other site
1218933003580	nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665
1218933003581	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1218933003582	ammonium transporter; Provisional; Region: PRK10666
1218933003583	acyl-CoA thioesterase II; Provisional; Region: PRK10526
1218933003584	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1218933003585	active site
1218933003586	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1218933003587	catalytic triad [active]
1218933003588	dimer interface [polypeptide binding]; other site
1218933003589	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; pfam09619
1218933003590	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1218933003591	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1218933003592	DNA binding site [nucleotide binding]
1218933003593	active site
1218933003594	Haemolysin expression modulating protein; Region: HHA; cl11501
1218933003595	Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757
1218933003596	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1218933003597	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
1218933003598	Protein export membrane protein; Region: SecD_SecF; cl14618
1218933003599	Protein export membrane protein; Region: SecD_SecF; cl14618
1218933003600	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
1218933003601	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1218933003602	HlyD family secretion protein; Region: HlyD_3; pfam13437
1218933003603	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
1218933003604	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1218933003605	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
1218933003606	hypothetical protein; Provisional; Region: PRK11038
1218933003607	Primosomal replication protein priB and priC; Region: priB_priC; pfam07445
1218933003608	hypothetical protein; Provisional; Region: PRK10527
1218933003609	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1218933003610	active site
1218933003611	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
1218933003612	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933003613	Walker A motif; other site
1218933003614	ATP binding site [chemical binding]; other site
1218933003615	Walker B motif; other site
1218933003616	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1218933003617	arginine finger; other site
1218933003618	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1218933003619	DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168
1218933003620	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
1218933003621	hypothetical protein; Validated; Region: PRK00153
1218933003622	recombination protein RecR; Reviewed; Region: recR; PRK00076
1218933003623	RecR protein; Region: RecR; pfam02132
1218933003624	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1218933003625	putative active site [active]
1218933003626	putative metal-binding site [ion binding]; other site
1218933003627	tetramer interface [polypeptide binding]; other site
1218933003628	heat shock protein 90; Provisional; Region: PRK05218
1218933003629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933003630	ATP binding site [chemical binding]; other site
1218933003631	Mg2+ binding site [ion binding]; other site
1218933003632	G-X-G motif; other site
1218933003633	adenylate kinase; Reviewed; Region: adk; PRK00279
1218933003634	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1218933003635	AMP-binding site [chemical binding]; other site
1218933003636	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1218933003637	ferrochelatase; Reviewed; Region: hemH; PRK00035
1218933003638	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1218933003639	C-terminal domain interface [polypeptide binding]; other site
1218933003640	active site
1218933003641	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1218933003642	active site
1218933003643	N-terminal domain interface [polypeptide binding]; other site
1218933003644	putative cation:proton antiport protein; Provisional; Region: PRK10669
1218933003645	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
1218933003646	TrkA-N domain; Region: TrkA_N; pfam02254
1218933003647	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
1218933003648	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
1218933003649	active site
1218933003650	metal binding site [ion binding]; metal-binding site
1218933003651	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1218933003652	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1218933003653	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1218933003654	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1218933003655	sugar binding site [chemical binding]; other site
1218933003656	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1218933003657	sugar binding site [chemical binding]; other site
1218933003658	carbon starvation protein A; Provisional; Region: PRK15015
1218933003659	Carbon starvation protein CstA; Region: CstA; pfam02554
1218933003660	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1218933003661	Uncharacterized small protein [Function unknown]; Region: COG2879
1218933003662	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
1218933003663	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
1218933003664	P-loop, Walker A motif; other site
1218933003665	Base recognition motif; other site
1218933003666	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1218933003667	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
1218933003668	Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295
1218933003669	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1218933003670	putative deacylase active site [active]
1218933003671	TraB family; Region: TraB; cl12050
1218933003672	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
1218933003673	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1218933003674	metal-binding site [ion binding]
1218933003675	copper exporting ATPase; Provisional; Region: copA; PRK10671
1218933003676	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1218933003677	metal-binding site [ion binding]
1218933003678	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1218933003679	metal-binding site [ion binding]
1218933003680	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1218933003681	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1218933003682	motif II; other site
1218933003683	DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227
1218933003684	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
1218933003685	DNA binding residues [nucleotide binding]
1218933003686	dimer interface [polypeptide binding]; other site
1218933003687	copper binding site [ion binding]; other site
1218933003688	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
1218933003689	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1218933003690	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1218933003691	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1218933003692	catalytic loop [active]
1218933003693	iron binding site [ion binding]; other site
1218933003694	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1218933003695	dimer interface [polypeptide binding]; other site
1218933003696	putative radical transfer pathway; other site
1218933003697	diiron center [ion binding]; other site
1218933003698	tyrosyl radical; other site
1218933003699	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
1218933003700	ATP cone domain; Region: ATP-cone; pfam03477
1218933003701	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1218933003702	active site
1218933003703	dimer interface [polypeptide binding]; other site
1218933003704	catalytic residues [active]
1218933003705	effector binding site; other site
1218933003706	R2 peptide binding site; other site
1218933003707	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
1218933003708	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933003709	S-adenosylmethionine binding site [chemical binding]; other site
1218933003710	DNA gyrase subunit A; Validated; Region: PRK05560
1218933003711	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1218933003712	CAP-like domain; other site
1218933003713	active site
1218933003714	primary dimer interface [polypeptide binding]; other site
1218933003715	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1218933003716	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1218933003717	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1218933003718	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1218933003719	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1218933003720	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1218933003721	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
1218933003722	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1218933003723	dimer interface [polypeptide binding]; other site
1218933003724	phosphorylation site [posttranslational modification]
1218933003725	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933003726	ATP binding site [chemical binding]; other site
1218933003727	Mg2+ binding site [ion binding]; other site
1218933003728	G-X-G motif; other site
1218933003729	RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456
1218933003730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933003731	active site
1218933003732	phosphorylation site [posttranslational modification]
1218933003733	intermolecular recognition site; other site
1218933003734	dimerization interface [polypeptide binding]; other site
1218933003735	transcriptional regulator RcsB; Provisional; Region: PRK10840
1218933003736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933003737	active site
1218933003738	phosphorylation site [posttranslational modification]
1218933003739	intermolecular recognition site; other site
1218933003740	dimerization interface [polypeptide binding]; other site
1218933003741	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1218933003742	DNA binding residues [nucleotide binding]
1218933003743	dimerization interface [polypeptide binding]; other site
1218933003744	phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618
1218933003745	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933003746	ATP binding site [chemical binding]; other site
1218933003747	G-X-G motif; other site
1218933003748	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1218933003749	putative binding surface; other site
1218933003750	active site
1218933003751	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933003752	menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012
1218933003753	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1218933003754	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
1218933003755	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1218933003756	dimer interface [polypeptide binding]; other site
1218933003757	tetramer interface [polypeptide binding]; other site
1218933003758	PYR/PP interface [polypeptide binding]; other site
1218933003759	TPP binding site [chemical binding]; other site
1218933003760	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1218933003761	TPP-binding site; other site
1218933003762	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
1218933003763	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1218933003764	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1218933003765	substrate binding site [chemical binding]; other site
1218933003766	oxyanion hole (OAH) forming residues; other site
1218933003767	trimer interface [polypeptide binding]; other site
1218933003768	O-succinylbenzoate synthase; Provisional; Region: PRK05105
1218933003769	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
1218933003770	active site
1218933003771	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
1218933003772	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
1218933003773	acyl-activating enzyme (AAE) consensus motif; other site
1218933003774	putative AMP binding site [chemical binding]; other site
1218933003775	putative active site [active]
1218933003776	putative CoA binding site [chemical binding]; other site
1218933003777	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
1218933003778	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
1218933003779	tyrosine transporter TyrP; Provisional; Region: PRK15132
1218933003780	aromatic amino acid transport protein; Region: araaP; TIGR00837
1218933003781	hypothetical protein; Provisional; Region: PRK03673
1218933003782	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1218933003783	putative MPT binding site; other site
1218933003784	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1218933003785	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
1218933003786	oxidoreductase; Provisional; Region: PRK08017
1218933003787	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1218933003788	NADP binding site [chemical binding]; other site
1218933003789	active site
1218933003790	steroid binding site; other site
1218933003791	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
1218933003792	active site
1218933003793	catalytic triad [active]
1218933003794	oxyanion hole [active]
1218933003795	switch loop; other site
1218933003796	putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584
1218933003797	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1218933003798	Walker A/P-loop; other site
1218933003799	ATP binding site [chemical binding]; other site
1218933003800	Q-loop/lid; other site
1218933003801	ABC transporter signature motif; other site
1218933003802	Walker B; other site
1218933003803	D-loop; other site
1218933003804	H-loop/switch region; other site
1218933003805	FtsX-like permease family; Region: FtsX; pfam02687
1218933003806	spermidine N1-acetyltransferase; Provisional; Region: PRK15130
1218933003807	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933003808	Coenzyme A binding pocket [chemical binding]; other site
1218933003809	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1218933003810	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933003811	N-terminal plug; other site
1218933003812	ligand-binding site [chemical binding]; other site
1218933003813	Periplasmic binding protein TroA_f.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139
1218933003814	putative ligand binding residues [chemical binding]; other site
1218933003815	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1218933003816	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1218933003817	active site
1218933003818	substrate binding site [chemical binding]; other site
1218933003819	cosubstrate binding site; other site
1218933003820	catalytic site [active]
1218933003821	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1218933003822	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1218933003823	dimerization interface [polypeptide binding]; other site
1218933003824	putative ATP binding site [chemical binding]; other site
1218933003825	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1218933003826	active site
1218933003827	uracil transporter; Provisional; Region: PRK10720
1218933003828	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
1218933003829	DNA replication initiation factor; Provisional; Region: PRK08084
1218933003830	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1218933003831	ArsC family; Region: ArsC; pfam03960
1218933003832	catalytic residues [active]
1218933003833	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
1218933003834	Peptidase family M48; Region: Peptidase_M48; pfam01435
1218933003835	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1218933003836	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1218933003837	catalytic triad [active]
1218933003838	glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589
1218933003839	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
1218933003840	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1218933003841	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1218933003842	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1218933003843	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1218933003844	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1218933003845	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1218933003846	dimer interface [polypeptide binding]; other site
1218933003847	active site
1218933003848	catalytic residue [active]
1218933003849	lipoprotein; Provisional; Region: PRK11679
1218933003850	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
1218933003851	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1218933003852	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1218933003853	ATP binding site [chemical binding]; other site
1218933003854	active site
1218933003855	substrate binding site [chemical binding]; other site
1218933003856	Predicted membrane protein [Function unknown]; Region: COG2707
1218933003857	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
1218933003858	Domain of unknown function (DUF1726); Region: DUF1726; pfam08351
1218933003859	Helicase; Region: Helicase_RecD; pfam05127
1218933003860	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
1218933003861	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
1218933003862	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1218933003863	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1218933003864	catalytic residues [active]
1218933003865	protease TldD; Provisional; Region: tldD; PRK10735
1218933003866	peptidase PmbA; Provisional; Region: PRK11040
1218933003867	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1218933003868	TolR protein; Region: tolR; TIGR02801
1218933003869	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1218933003870	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1218933003871	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1218933003872	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
1218933003873	FecR protein; Region: FecR; pfam04773
1218933003874	RNA polymerase sigma factor; Provisional; Region: PRK12525
1218933003875	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1218933003876	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1218933003877	DNA binding residues [nucleotide binding]
1218933003878	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1218933003879	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933003880	N-terminal plug; other site
1218933003881	ligand-binding site [chemical binding]; other site
1218933003882	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1218933003883	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
1218933003884	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
1218933003885	Predicted ATPase [General function prediction only]; Region: COG3910
1218933003886	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933003887	Walker A/P-loop; other site
1218933003888	ATP binding site [chemical binding]; other site
1218933003889	Q-loop/lid; other site
1218933003890	ABC transporter signature motif; other site
1218933003891	Walker B; other site
1218933003892	D-loop; other site
1218933003893	H-loop/switch region; other site
1218933003894	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
1218933003895	catalytic triad [active]
1218933003896	putative active site [active]
1218933003897	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1218933003898	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
1218933003899	Autotransporter beta-domain; Region: Autotransporter; smart00869
1218933003900	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
1218933003901	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
1218933003902	putative hydrolase; Provisional; Region: PRK11460
1218933003903	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
1218933003904	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
1218933003905	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
1218933003906	dimer interface [polypeptide binding]; other site
1218933003907	ligand binding site [chemical binding]; other site
1218933003908	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933003909	dimerization interface [polypeptide binding]; other site
1218933003910	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933003911	dimer interface [polypeptide binding]; other site
1218933003912	putative CheW interface [polypeptide binding]; other site
1218933003913	Uncharacterized protein family (UPF0370); Region: UPF0370; pfam13980
1218933003914	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1218933003915	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1218933003916	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
1218933003917	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
1218933003918	metal binding site [ion binding]; metal-binding site
1218933003919	dimer interface [polypeptide binding]; other site
1218933003920	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
1218933003921	ArsC family; Region: ArsC; pfam03960
1218933003922	putative catalytic residues [active]
1218933003923	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
1218933003924	aspartate racemase; Region: asp_race; TIGR00035
1218933003925	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1218933003926	DNA-binding site [nucleotide binding]; DNA binding site
1218933003927	RNA-binding motif; other site
1218933003928	chromosome condensation membrane protein; Provisional; Region: PRK14196
1218933003929	twin arginine translocase protein A; Validated; Region: tatE; PRK01614
1218933003930	lipoyl synthase; Provisional; Region: PRK05481
1218933003931	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1218933003932	FeS/SAM binding site; other site
1218933003933	lipoate-protein ligase B; Provisional; Region: PRK14342
1218933003934	hypothetical protein; Provisional; Region: PRK04998
1218933003935	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
1218933003936	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1218933003937	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1218933003938	rare lipoprotein A; Provisional; Region: PRK10672
1218933003939	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1218933003940	Sporulation related domain; Region: SPOR; pfam05036
1218933003941	cell wall shape-determining protein; Provisional; Region: PRK10794
1218933003942	penicillin-binding protein 2; Provisional; Region: PRK10795
1218933003943	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1218933003944	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1218933003945	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
1218933003946	ribosome-associated protein; Provisional; Region: PRK11538
1218933003947	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1218933003948	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1218933003949	active site
1218933003950	(T/H)XGH motif; other site
1218933003951	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1218933003952	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1218933003953	LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796
1218933003954	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1218933003955	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1218933003956	HIGH motif; other site
1218933003957	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1218933003958	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1218933003959	active site
1218933003960	KMSKS motif; other site
1218933003961	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1218933003962	tRNA binding surface [nucleotide binding]; other site
1218933003963	hypothetical protein; Provisional; Region: PRK11032
1218933003964	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1218933003965	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1218933003966	Walker A/P-loop; other site
1218933003967	ATP binding site [chemical binding]; other site
1218933003968	Q-loop/lid; other site
1218933003969	ABC transporter signature motif; other site
1218933003970	Walker B; other site
1218933003971	D-loop; other site
1218933003972	H-loop/switch region; other site
1218933003973	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1218933003974	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933003975	dimer interface [polypeptide binding]; other site
1218933003976	conserved gate region; other site
1218933003977	putative PBP binding loops; other site
1218933003978	ABC-ATPase subunit interface; other site
1218933003979	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1218933003980	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933003981	dimer interface [polypeptide binding]; other site
1218933003982	conserved gate region; other site
1218933003983	putative PBP binding loops; other site
1218933003984	ABC-ATPase subunit interface; other site
1218933003985	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
1218933003986	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1218933003987	substrate binding pocket [chemical binding]; other site
1218933003988	membrane-bound complex binding site; other site
1218933003989	hinge residues; other site
1218933003990	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
1218933003991	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1218933003992	putative active site [active]
1218933003993	catalytic triad [active]
1218933003994	putative dimer interface [polypeptide binding]; other site
1218933003995	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
1218933003996	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1218933003997	Transporter associated domain; Region: CorC_HlyC; smart01091
1218933003998	metal-binding heat shock protein; Provisional; Region: PRK00016
1218933003999	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1218933004000	PhoH-like protein; Region: PhoH; pfam02562
1218933004001	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
1218933004002	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1218933004003	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1218933004004	FeS/SAM binding site; other site
1218933004005	TRAM domain; Region: TRAM; pfam01938
1218933004006	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1218933004007	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
1218933004008	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
1218933004009	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
1218933004010	asparagine synthetase B; Provisional; Region: asnB; PRK09431
1218933004011	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1218933004012	dimer interface [polypeptide binding]; other site
1218933004013	active site
1218933004014	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1218933004015	Ligand Binding Site [chemical binding]; other site
1218933004016	Molecular Tunnel; other site
1218933004017	MarR family; Region: MarR; pfam01047
1218933004018	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1218933004019	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1218933004020	nucleotide binding site [chemical binding]; other site
1218933004021	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1218933004022	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1218933004023	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1218933004024	active site
1218933004025	dimer interface [polypeptide binding]; other site
1218933004026	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1218933004027	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1218933004028	active site
1218933004029	trimer interface [polypeptide binding]; other site
1218933004030	allosteric site; other site
1218933004031	active site lid [active]
1218933004032	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1218933004033	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1218933004034	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1218933004035	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1218933004036	active site turn [active]
1218933004037	phosphorylation site [posttranslational modification]
1218933004038	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
1218933004039	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1218933004040	active site
1218933004041	HIGH motif; other site
1218933004042	nucleotide binding site [chemical binding]; other site
1218933004043	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
1218933004044	KMSKS motif; other site
1218933004045	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
1218933004046	ferric uptake regulator; Provisional; Region: fur; PRK09462
1218933004047	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1218933004048	metal binding site 2 [ion binding]; metal-binding site
1218933004049	putative DNA binding helix; other site
1218933004050	metal binding site 1 [ion binding]; metal-binding site
1218933004051	dimer interface [polypeptide binding]; other site
1218933004052	structural Zn2+ binding site [ion binding]; other site
1218933004053	flavodoxin FldA; Validated; Region: PRK09267
1218933004054	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
1218933004055	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933004056	dimer interface [polypeptide binding]; other site
1218933004057	putative CheW interface [polypeptide binding]; other site
1218933004058	LexA regulated protein; Provisional; Region: PRK11675
1218933004059	acyl-CoA esterase; Provisional; Region: PRK10673
1218933004060	PGAP1-like protein; Region: PGAP1; pfam07819
1218933004061	replication initiation regulator SeqA; Provisional; Region: PRK11187
1218933004062	phosphoglucomutase; Validated; Region: PRK07564
1218933004063	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
1218933004064	active site
1218933004065	substrate binding site [chemical binding]; other site
1218933004066	metal binding site [ion binding]; metal-binding site
1218933004067	Predicted membrane protein [Function unknown]; Region: COG2510
1218933004068	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
1218933004069	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933004070	active site
1218933004071	phosphorylation site [posttranslational modification]
1218933004072	intermolecular recognition site; other site
1218933004073	dimerization interface [polypeptide binding]; other site
1218933004074	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1218933004075	DNA binding site [nucleotide binding]
1218933004076	sensor protein KdpD; Provisional; Region: PRK10490
1218933004077	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1218933004078	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1218933004079	Ligand Binding Site [chemical binding]; other site
1218933004080	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
1218933004081	GAF domain; Region: GAF_3; pfam13492
1218933004082	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1218933004083	dimer interface [polypeptide binding]; other site
1218933004084	phosphorylation site [posttranslational modification]
1218933004085	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933004086	ATP binding site [chemical binding]; other site
1218933004087	Mg2+ binding site [ion binding]; other site
1218933004088	G-X-G motif; other site
1218933004089	K+-transporting ATPase, c chain; Region: KdpC; cl00944
1218933004090	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1218933004091	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1218933004092	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
1218933004093	Protein of unknown function (DUF2517); Region: DUF2517; pfam10725
1218933004094	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1218933004095	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1218933004096	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933004097	dimer interface [polypeptide binding]; other site
1218933004098	conserved gate region; other site
1218933004099	putative PBP binding loops; other site
1218933004100	ABC-ATPase subunit interface; other site
1218933004101	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1218933004102	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1218933004103	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1218933004104	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1218933004105	Walker A/P-loop; other site
1218933004106	ATP binding site [chemical binding]; other site
1218933004107	Q-loop/lid; other site
1218933004108	ABC transporter signature motif; other site
1218933004109	Walker B; other site
1218933004110	D-loop; other site
1218933004111	H-loop/switch region; other site
1218933004112	Protein of unknown function (DUF523); Region: DUF523; pfam04463
1218933004113	Uncharacterized conserved protein [Function unknown]; Region: COG3272
1218933004114	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
1218933004115	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
1218933004116	DNA photolyase; Region: DNA_photolyase; pfam00875
1218933004117	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1218933004118	metal-binding protein; Provisional; Region: PRK10799
1218933004119	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1218933004120	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1218933004121	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1218933004122	LamB/YcsF family protein; Provisional; Region: PRK05406
1218933004123	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
1218933004124	putative substrate binding pocket [chemical binding]; other site
1218933004125	AC domain interface; other site
1218933004126	catalytic triad [active]
1218933004127	AB domain interface; other site
1218933004128	interchain disulfide; other site
1218933004129	endonuclease VIII; Provisional; Region: PRK10445
1218933004130	N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119
1218933004131	DNA binding site [nucleotide binding]
1218933004132	catalytic residue [active]
1218933004133	H2TH interface [polypeptide binding]; other site
1218933004134	putative catalytic residues [active]
1218933004135	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1218933004136	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1218933004137	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
1218933004138	dimer interface [polypeptide binding]; other site
1218933004139	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1218933004140	ligand binding site [chemical binding]; other site
1218933004141	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1218933004142	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1218933004143	dimer interface [polypeptide binding]; other site
1218933004144	active site
1218933004145	citrylCoA binding site [chemical binding]; other site
1218933004146	NADH binding [chemical binding]; other site
1218933004147	cationic pore residues; other site
1218933004148	oxalacetate/citrate binding site [chemical binding]; other site
1218933004149	coenzyme A binding site [chemical binding]; other site
1218933004150	catalytic triad [active]
1218933004151	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
1218933004152	Iron-sulfur protein interface; other site
1218933004153	proximal quinone binding site [chemical binding]; other site
1218933004154	SdhD (CybS) interface [polypeptide binding]; other site
1218933004155	proximal heme binding site [chemical binding]; other site
1218933004156	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
1218933004157	SdhC subunit interface [polypeptide binding]; other site
1218933004158	proximal heme binding site [chemical binding]; other site
1218933004159	cardiolipin binding site; other site
1218933004160	Iron-sulfur protein interface; other site
1218933004161	proximal quinone binding site [chemical binding]; other site
1218933004162	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
1218933004163	L-aspartate oxidase; Provisional; Region: PRK06175
1218933004164	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1218933004165	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
1218933004166	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1218933004167	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1218933004168	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1218933004169	TPP-binding site [chemical binding]; other site
1218933004170	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1218933004171	dimer interface [polypeptide binding]; other site
1218933004172	PYR/PP interface [polypeptide binding]; other site
1218933004173	TPP binding site [chemical binding]; other site
1218933004174	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1218933004175	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1218933004176	E3 interaction surface; other site
1218933004177	lipoyl attachment site [posttranslational modification]; other site
1218933004178	e3 binding domain; Region: E3_binding; pfam02817
1218933004179	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1218933004180	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1218933004181	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1218933004182	CoA-ligase; Region: Ligase_CoA; pfam00549
1218933004183	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1218933004184	CoA binding domain; Region: CoA_binding; smart00881
1218933004185	CoA-ligase; Region: Ligase_CoA; pfam00549
1218933004186	TPR repeat; Region: TPR_11; pfam13414
1218933004187	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1218933004188	TPR motif; other site
1218933004189	binding surface
1218933004190	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1218933004191	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1218933004192	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
1218933004193	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1218933004194	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1218933004195	Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173
1218933004196	hypothetical protein; Provisional; Region: PRK10588
1218933004197	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1218933004198	active site
1218933004199	colicin uptake protein TolQ; Provisional; Region: PRK10801
1218933004200	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1218933004201	colicin uptake protein TolR; Provisional; Region: PRK11024
1218933004202	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
1218933004203	TolA C-terminal; Region: TolA; pfam06519
1218933004204	translocation protein TolB; Provisional; Region: tolB; PRK03629
1218933004205	TolB amino-terminal domain; Region: TolB_N; pfam04052
1218933004206	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1218933004207	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1218933004208	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
1218933004209	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1218933004210	ligand binding site [chemical binding]; other site
1218933004211	tol-pal system protein YbgF; Provisional; Region: PRK10803
1218933004212	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1218933004213	TPR motif; other site
1218933004214	binding surface
1218933004215	Protein of unknown function (DUF554); Region: DUF554; pfam04474
1218933004216	hypothetical protein; Provisional; Region: PRK10039
1218933004217	quinolinate synthetase; Provisional; Region: PRK09375
1218933004218	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
1218933004219	zinc transporter ZitB; Provisional; Region: PRK03557
1218933004220	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
1218933004221	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1218933004222	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1218933004223	catalytic core [active]
1218933004224	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1218933004225	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
1218933004226	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
1218933004227	HlyD family secretion protein; Region: HlyD_3; pfam13437
1218933004228	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
1218933004229	Outer membrane efflux protein; Region: OEP; pfam02321
1218933004230	Outer membrane efflux protein; Region: OEP; pfam02321
1218933004231	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
1218933004232	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1218933004233	active site
1218933004234	catalytic residues [active]
1218933004235	UDP-galactose-4-epimerase; Provisional; Region: PRK10675
1218933004236	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1218933004237	NAD binding site [chemical binding]; other site
1218933004238	homodimer interface [polypeptide binding]; other site
1218933004239	active site
1218933004240	substrate binding site [chemical binding]; other site
1218933004241	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
1218933004242	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
1218933004243	Walker A/P-loop; other site
1218933004244	ATP binding site [chemical binding]; other site
1218933004245	Q-loop/lid; other site
1218933004246	ABC transporter signature motif; other site
1218933004247	Walker B; other site
1218933004248	D-loop; other site
1218933004249	H-loop/switch region; other site
1218933004250	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933004251	Walker A/P-loop; other site
1218933004252	ATP binding site [chemical binding]; other site
1218933004253	Q-loop/lid; other site
1218933004254	ABC transporter signature motif; other site
1218933004255	Walker B; other site
1218933004256	D-loop; other site
1218933004257	H-loop/switch region; other site
1218933004258	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
1218933004259	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
1218933004260	molybdenum-pterin binding domain; Region: Mop; TIGR00638
1218933004261	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
1218933004262	Protein of unknown function (DUF2592); Region: DUF2592; pfam10766
1218933004263	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
1218933004264	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1218933004265	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1218933004266	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933004267	dimer interface [polypeptide binding]; other site
1218933004268	conserved gate region; other site
1218933004269	putative PBP binding loops; other site
1218933004270	ABC-ATPase subunit interface; other site
1218933004271	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
1218933004272	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933004273	Walker A/P-loop; other site
1218933004274	ATP binding site [chemical binding]; other site
1218933004275	Q-loop/lid; other site
1218933004276	ABC transporter signature motif; other site
1218933004277	Walker B; other site
1218933004278	D-loop; other site
1218933004279	H-loop/switch region; other site
1218933004280	molybdenum-pterin binding domain; Region: Mop; TIGR00638
1218933004281	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1218933004282	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
1218933004283	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1218933004284	ligand binding site [chemical binding]; other site
1218933004285	dimerization interface [polypeptide binding]; other site
1218933004286	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1218933004287	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1218933004288	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1218933004289	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1218933004290	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1218933004291	Metal-binding active site; metal-binding site
1218933004292	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1218933004293	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
1218933004294	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
1218933004295	putative substrate translocation pore; other site
1218933004296	glucokinase; Provisional; Region: glk; PRK00292
1218933004297	glucokinase, proteobacterial type; Region: glk; TIGR00749
1218933004298	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
1218933004299	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1218933004300	active site
1218933004301	motif I; other site
1218933004302	motif II; other site
1218933004303	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1218933004304	6-phosphogluconolactonase; Provisional; Region: PRK11028
1218933004305	Uncharacterized conserved protein [Function unknown]; Region: COG5276
1218933004306	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
1218933004307	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1218933004308	putative ligand binding site [chemical binding]; other site
1218933004309	formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179
1218933004310	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
1218933004311	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
1218933004312	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
1218933004313	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
1218933004314	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
1218933004315	[4Fe-4S] binding site [ion binding]; other site
1218933004316	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1218933004317	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
1218933004318	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1218933004319	molybdopterin cofactor binding site; other site
1218933004320	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
1218933004321	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1218933004322	active site
1218933004323	HIGH motif; other site
1218933004324	KMSKS motif; other site
1218933004325	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1218933004326	tRNA binding surface [nucleotide binding]; other site
1218933004327	anticodon binding site; other site
1218933004328	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1218933004329	dimer interface [polypeptide binding]; other site
1218933004330	putative tRNA-binding site [nucleotide binding]; other site
1218933004331	antiporter inner membrane protein; Provisional; Region: PRK11670
1218933004332	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1218933004333	Walker A motif; other site
1218933004334	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1218933004335	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1218933004336	Sugar specificity; other site
1218933004337	Pyrimidine base specificity; other site
1218933004338	ATP-binding site [chemical binding]; other site
1218933004339	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1218933004340	trimer interface [polypeptide binding]; other site
1218933004341	active site
1218933004342	putative assembly protein; Provisional; Region: PRK10833
1218933004343	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1218933004344	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
1218933004345	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1218933004346	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1218933004347	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
1218933004348	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1218933004349	Transporter associated domain; Region: CorC_HlyC; smart01091
1218933004350	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
1218933004351	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1218933004352	Mg++ binding site [ion binding]; other site
1218933004353	putative catalytic motif [active]
1218933004354	substrate binding site [chemical binding]; other site
1218933004355	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1218933004356	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
1218933004357	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1218933004358	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1218933004359	active site
1218933004360	tyrosine kinase; Provisional; Region: PRK11519
1218933004361	Chain length determinant protein; Region: Wzz; pfam02706
1218933004362	Chain length determinant protein; Region: Wzz; cl15801
1218933004363	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1218933004364	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1218933004365	Nucleotide binding site [chemical binding]; other site
1218933004366	DTAP/Switch II; other site
1218933004367	Switch I; other site
1218933004368	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1218933004369	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1218933004370	substrate binding site; other site
1218933004371	tetramer interface; other site
1218933004372	WxcM-like, C-terminal; Region: FdtA; pfam05523
1218933004373	Formyltransferase, catalytic core domain; Region: FMT_core; cd08369
1218933004374	active site
1218933004375	substrate binding site [chemical binding]; other site
1218933004376	cosubstrate binding site; other site
1218933004377	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
1218933004378	catalytic site [active]
1218933004379	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
1218933004380	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
1218933004381	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1218933004382	inhibitor-cofactor binding pocket; inhibition site
1218933004383	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933004384	catalytic residue [active]
1218933004385	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1218933004386	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
1218933004387	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1218933004388	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1218933004389	active site
1218933004390	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1218933004391	putative trimer interface [polypeptide binding]; other site
1218933004392	putative CoA binding site [chemical binding]; other site
1218933004393	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1218933004394	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1218933004395	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1218933004396	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1218933004397	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1218933004398	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1218933004399	NADP-binding site; other site
1218933004400	homotetramer interface [polypeptide binding]; other site
1218933004401	substrate binding site [chemical binding]; other site
1218933004402	homodimer interface [polypeptide binding]; other site
1218933004403	active site
1218933004404	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
1218933004405	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
1218933004406	NADP binding site [chemical binding]; other site
1218933004407	active site
1218933004408	putative substrate binding site [chemical binding]; other site
1218933004409	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
1218933004410	active site
1218933004411	GDP-Mannose binding site [chemical binding]; other site
1218933004412	dimer interface [polypeptide binding]; other site
1218933004413	modified nudix motif
1218933004414	metal binding site [ion binding]; metal-binding site
1218933004415	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1218933004416	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1218933004417	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
1218933004418	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1218933004419	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
1218933004420	metal-binding site
1218933004421	phosphomannomutase CpsG; Provisional; Region: PRK15414
1218933004422	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1218933004423	active site
1218933004424	substrate binding site [chemical binding]; other site
1218933004425	metal binding site [ion binding]; metal-binding site
1218933004426	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1218933004427	active site
1218933004428	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1218933004429	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1218933004430	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1218933004431	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
1218933004432	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
1218933004433	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
1218933004434	chorismate mutase; Provisional; Region: PRK08055
1218933004435	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
1218933004436	peptidase domain interface [polypeptide binding]; other site
1218933004437	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
1218933004438	active site
1218933004439	catalytic triad [active]
1218933004440	calcium binding site [ion binding]; other site
1218933004441	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1218933004442	beta-galactosidase; Region: BGL; TIGR03356
1218933004443	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1218933004444	CAT RNA binding domain; Region: CAT_RBD; smart01061
1218933004445	PRD domain; Region: PRD; pfam00874
1218933004446	PRD domain; Region: PRD; pfam00874
1218933004447	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
1218933004448	MASE2 domain; Region: MASE2; pfam05230
1218933004449	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1218933004450	metal binding site [ion binding]; metal-binding site
1218933004451	active site
1218933004452	I-site; other site
1218933004453	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1218933004454	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1218933004455	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1218933004456	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1218933004457	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1218933004458	putative active site [active]
1218933004459	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1218933004460	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1218933004461	tetrameric interface [polypeptide binding]; other site
1218933004462	NAD binding site [chemical binding]; other site
1218933004463	catalytic residues [active]
1218933004464	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1218933004465	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1218933004466	PYR/PP interface [polypeptide binding]; other site
1218933004467	dimer interface [polypeptide binding]; other site
1218933004468	TPP binding site [chemical binding]; other site
1218933004469	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1218933004470	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
1218933004471	TPP-binding site; other site
1218933004472	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1218933004473	FMN binding site [chemical binding]; other site
1218933004474	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1218933004475	dimer interface [polypeptide binding]; other site
1218933004476	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933004477	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933004478	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1218933004479	putative effector binding pocket; other site
1218933004480	putative dimerization interface [polypeptide binding]; other site
1218933004481	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1218933004482	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1218933004483	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1218933004484	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1218933004485	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1218933004486	ligand binding site [chemical binding]; other site
1218933004487	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1218933004488	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1218933004489	Walker A/P-loop; other site
1218933004490	ATP binding site [chemical binding]; other site
1218933004491	Q-loop/lid; other site
1218933004492	ABC transporter signature motif; other site
1218933004493	Walker B; other site
1218933004494	D-loop; other site
1218933004495	H-loop/switch region; other site
1218933004496	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1218933004497	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1218933004498	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1218933004499	TM-ABC transporter signature motif; other site
1218933004500	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1218933004501	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1218933004502	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1218933004503	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1218933004504	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1218933004505	substrate binding site [chemical binding]; other site
1218933004506	ATP binding site [chemical binding]; other site
1218933004507	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
1218933004508	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
1218933004509	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1218933004510	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1218933004511	Metal-binding active site; metal-binding site
1218933004512	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
1218933004513	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
1218933004514	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
1218933004515	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
1218933004516	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933004517	Walker A/P-loop; other site
1218933004518	ATP binding site [chemical binding]; other site
1218933004519	Q-loop/lid; other site
1218933004520	ABC transporter signature motif; other site
1218933004521	Walker B; other site
1218933004522	D-loop; other site
1218933004523	H-loop/switch region; other site
1218933004524	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1218933004525	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933004526	dimer interface [polypeptide binding]; other site
1218933004527	conserved gate region; other site
1218933004528	putative PBP binding loops; other site
1218933004529	ABC-ATPase subunit interface; other site
1218933004530	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933004531	dimer interface [polypeptide binding]; other site
1218933004532	conserved gate region; other site
1218933004533	putative PBP binding loops; other site
1218933004534	ABC-ATPase subunit interface; other site
1218933004535	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1218933004536	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1218933004537	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1218933004538	CAT RNA binding domain; Region: CAT_RBD; smart01061
1218933004539	PRD domain; Region: PRD; pfam00874
1218933004540	PRD domain; Region: PRD; pfam00874
1218933004541	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1218933004542	beta-galactosidase; Region: BGL; TIGR03356
1218933004543	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1218933004544	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
1218933004545	active site turn [active]
1218933004546	phosphorylation site [posttranslational modification]
1218933004547	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1218933004548	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1218933004549	HPr interaction site; other site
1218933004550	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1218933004551	active site
1218933004552	phosphorylation site [posttranslational modification]
1218933004553	GAF domain; Region: GAF; cl17456
1218933004554	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1218933004555	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1218933004556	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1218933004557	metal binding site [ion binding]; metal-binding site
1218933004558	active site
1218933004559	I-site; other site
1218933004560	Domain of unknown function (DUF1869); Region: DUF1869; pfam08956
1218933004561	Domain of unknown function (DUF1971); Region: DUF1971; cl17717
1218933004562	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1218933004563	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
1218933004564	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
1218933004565	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933004566	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933004567	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1218933004568	putative effector binding pocket; other site
1218933004569	dimerization interface [polypeptide binding]; other site
1218933004570	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1218933004571	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1218933004572	NAD binding site [chemical binding]; other site
1218933004573	substrate binding site [chemical binding]; other site
1218933004574	putative active site [active]
1218933004575	galactoside permease; Reviewed; Region: lacY; PRK09528
1218933004576	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933004577	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
1218933004578	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1218933004579	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1218933004580	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1218933004581	Beta galactosidase small chain; Region: Bgal_small_N; pfam02929
1218933004582	lac repressor; Reviewed; Region: lacI; PRK09526
1218933004583	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1218933004584	DNA binding site [nucleotide binding]
1218933004585	domain linker motif; other site
1218933004586	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
1218933004587	ligand binding site [chemical binding]; other site
1218933004588	dimerization interface (open form) [polypeptide binding]; other site
1218933004589	dimerization interface (closed form) [polypeptide binding]; other site
1218933004590	ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432
1218933004591	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1218933004592	Walker A/P-loop; other site
1218933004593	ATP binding site [chemical binding]; other site
1218933004594	Q-loop/lid; other site
1218933004595	ABC transporter signature motif; other site
1218933004596	Walker B; other site
1218933004597	D-loop; other site
1218933004598	H-loop/switch region; other site
1218933004599	TOBE domain; Region: TOBE_2; pfam08402
1218933004600	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1218933004601	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933004602	dimer interface [polypeptide binding]; other site
1218933004603	conserved gate region; other site
1218933004604	putative PBP binding loops; other site
1218933004605	ABC-ATPase subunit interface; other site
1218933004606	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933004607	dimer interface [polypeptide binding]; other site
1218933004608	conserved gate region; other site
1218933004609	putative PBP binding loops; other site
1218933004610	ABC-ATPase subunit interface; other site
1218933004611	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1218933004612	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1218933004613	regulatory protein UhpC; Provisional; Region: PRK11663
1218933004614	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933004615	putative substrate translocation pore; other site
1218933004616	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933004617	MASE1; Region: MASE1; pfam05231
1218933004618	Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851
1218933004619	Histidine kinase; Region: HisKA_3; pfam07730
1218933004620	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933004621	ATP binding site [chemical binding]; other site
1218933004622	Mg2+ binding site [ion binding]; other site
1218933004623	G-X-G motif; other site
1218933004624	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1218933004625	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933004626	active site
1218933004627	phosphorylation site [posttranslational modification]
1218933004628	intermolecular recognition site; other site
1218933004629	dimerization interface [polypeptide binding]; other site
1218933004630	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1218933004631	DNA binding residues [nucleotide binding]
1218933004632	dimerization interface [polypeptide binding]; other site
1218933004633	cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861
1218933004634	lipoprotein, YaeC family; Region: TIGR00363
1218933004635	Pectate lyase; Region: Pec_lyase_C; pfam00544
1218933004636	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1218933004637	aspartate racemase; Region: asp_race; TIGR00035
1218933004638	cell density-dependent motility repressor; Provisional; Region: PRK10082
1218933004639	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933004640	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1218933004641	dimerization interface [polypeptide binding]; other site
1218933004642	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1218933004643	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1218933004644	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933004645	DNA-binding site [nucleotide binding]; DNA binding site
1218933004646	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1218933004647	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1218933004648	DNA-binding site [nucleotide binding]; DNA binding site
1218933004649	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1218933004650	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
1218933004651	Citrate transporter; Region: CitMHS; pfam03600
1218933004652	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
1218933004653	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1218933004654	[4Fe-4S] binding site [ion binding]; other site
1218933004655	molybdopterin cofactor binding site; other site
1218933004656	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
1218933004657	molybdopterin cofactor binding site; other site
1218933004658	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
1218933004659	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1218933004660	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933004661	dimer interface [polypeptide binding]; other site
1218933004662	putative CheW interface [polypeptide binding]; other site
1218933004663	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
1218933004664	Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470
1218933004665	Predicted membrane protein [Function unknown]; Region: COG4393
1218933004666	Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080
1218933004667	Uncharacterized conserved protein [Function unknown]; Region: COG3350
1218933004668	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1218933004669	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1218933004670	FtsX-like permease family; Region: FtsX; pfam02687
1218933004671	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1218933004672	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1218933004673	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1218933004674	Walker A/P-loop; other site
1218933004675	ATP binding site [chemical binding]; other site
1218933004676	Q-loop/lid; other site
1218933004677	ABC transporter signature motif; other site
1218933004678	Walker B; other site
1218933004679	D-loop; other site
1218933004680	H-loop/switch region; other site
1218933004681	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1218933004682	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1218933004683	catalytic residues [active]
1218933004684	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1218933004685	EamA-like transporter family; Region: EamA; pfam00892
1218933004686	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1218933004687	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933004688	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1218933004689	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933004690	transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679
1218933004691	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
1218933004692	substrate binding site [chemical binding]; other site
1218933004693	dimerization interface [polypeptide binding]; other site
1218933004694	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
1218933004695	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1218933004696	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
1218933004697	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
1218933004698	putative active site [active]
1218933004699	metal binding site [ion binding]; metal-binding site
1218933004700	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
1218933004701	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
1218933004702	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1218933004703	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1218933004704	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1218933004705	HlyD family secretion protein; Region: HlyD_3; pfam13437
1218933004706	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
1218933004707	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
1218933004708	Walker A/P-loop; other site
1218933004709	ATP binding site [chemical binding]; other site
1218933004710	Q-loop/lid; other site
1218933004711	ABC transporter signature motif; other site
1218933004712	Walker B; other site
1218933004713	D-loop; other site
1218933004714	H-loop/switch region; other site
1218933004715	Heme-binding protein A (HasA); Region: HasA; pfam06438
1218933004716	Secretin and TonB N terminus short domain; Region: STN; smart00965
1218933004717	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
1218933004718	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933004719	N-terminal plug; other site
1218933004720	ligand-binding site [chemical binding]; other site
1218933004721	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
1218933004722	Src homology 2 (SH2) domain; Region: SH2; cl15255
1218933004723	phosphotyrosine binding pocket [polypeptide binding]; other site
1218933004724	FecR protein; Region: FecR; pfam04773
1218933004725	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1218933004726	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1218933004727	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1218933004728	DNA binding residues [nucleotide binding]
1218933004729	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
1218933004730	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
1218933004731	tetrameric interface [polypeptide binding]; other site
1218933004732	NAD binding site [chemical binding]; other site
1218933004733	catalytic residues [active]
1218933004734	substrate binding site [chemical binding]; other site
1218933004735	putrescine aminotransferase; Region: putres_am_tran; TIGR03372
1218933004736	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1218933004737	inhibitor-cofactor binding pocket; inhibition site
1218933004738	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933004739	catalytic residue [active]
1218933004740	Carboxylesterase family; Region: COesterase; pfam00135
1218933004741	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1218933004742	substrate binding pocket [chemical binding]; other site
1218933004743	catalytic triad [active]
1218933004744	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933004745	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1218933004746	S-adenosylmethionine binding site [chemical binding]; other site
1218933004747	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1218933004748	proline/glycine betaine transporter; Provisional; Region: PRK10642
1218933004749	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933004750	putative substrate translocation pore; other site
1218933004751	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
1218933004752	AMP nucleosidase; Provisional; Region: PRK08292
1218933004753	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
1218933004754	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
1218933004755	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1218933004756	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1218933004757	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
1218933004758	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1218933004759	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933004760	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1218933004761	putative substrate translocation pore; other site
1218933004762	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1218933004763	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933004764	Walker A/P-loop; other site
1218933004765	ATP binding site [chemical binding]; other site
1218933004766	Q-loop/lid; other site
1218933004767	ABC transporter signature motif; other site
1218933004768	Walker B; other site
1218933004769	D-loop; other site
1218933004770	H-loop/switch region; other site
1218933004771	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1218933004772	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933004773	Walker A/P-loop; other site
1218933004774	ATP binding site [chemical binding]; other site
1218933004775	Q-loop/lid; other site
1218933004776	ABC transporter signature motif; other site
1218933004777	Walker B; other site
1218933004778	D-loop; other site
1218933004779	H-loop/switch region; other site
1218933004780	hypothetical protein; Provisional; Region: PRK09956
1218933004781	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1218933004782	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1218933004783	catalytic residues [active]
1218933004784	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1218933004785	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1218933004786	Walker A/P-loop; other site
1218933004787	ATP binding site [chemical binding]; other site
1218933004788	Q-loop/lid; other site
1218933004789	ABC transporter signature motif; other site
1218933004790	Walker B; other site
1218933004791	D-loop; other site
1218933004792	H-loop/switch region; other site
1218933004793	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1218933004794	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1218933004795	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1218933004796	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933004797	dimer interface [polypeptide binding]; other site
1218933004798	conserved gate region; other site
1218933004799	putative PBP binding loops; other site
1218933004800	ABC-ATPase subunit interface; other site
1218933004801	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1218933004802	NMT1-like family; Region: NMT1_2; pfam13379
1218933004803	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933004804	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933004805	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1218933004806	dimerization interface [polypeptide binding]; other site
1218933004807	CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471
1218933004808	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1218933004809	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933004810	N-terminal plug; other site
1218933004811	ligand-binding site [chemical binding]; other site
1218933004812	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
1218933004813	muropeptide transporter; Validated; Region: ampG; cl17669
1218933004814	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1218933004815	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933004816	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1218933004817	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1218933004818	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933004819	Walker A/P-loop; other site
1218933004820	ATP binding site [chemical binding]; other site
1218933004821	Q-loop/lid; other site
1218933004822	ABC transporter signature motif; other site
1218933004823	Walker B; other site
1218933004824	D-loop; other site
1218933004825	H-loop/switch region; other site
1218933004826	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
1218933004827	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1218933004828	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933004829	Walker A/P-loop; other site
1218933004830	ATP binding site [chemical binding]; other site
1218933004831	Q-loop/lid; other site
1218933004832	ABC transporter signature motif; other site
1218933004833	Walker B; other site
1218933004834	D-loop; other site
1218933004835	H-loop/switch region; other site
1218933004836	transcriptional regulator TraR; Provisional; Region: PRK13870
1218933004837	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1218933004838	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1218933004839	DNA binding residues [nucleotide binding]
1218933004840	dimerization interface [polypeptide binding]; other site
1218933004841	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1218933004842	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1218933004843	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
1218933004844	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
1218933004845	Protein of unknown function (DUF330); Region: DUF330; pfam03886
1218933004846	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
1218933004847	mce related protein; Region: MCE; pfam02470
1218933004848	mce related protein; Region: MCE; pfam02470
1218933004849	mce related protein; Region: MCE; pfam02470
1218933004850	Paraquat-inducible protein A; Region: PqiA; pfam04403
1218933004851	Paraquat-inducible protein A; Region: PqiA; pfam04403
1218933004852	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
1218933004853	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1218933004854	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933004855	Response regulator receiver domain; Region: Response_reg; pfam00072
1218933004856	active site
1218933004857	phosphorylation site [posttranslational modification]
1218933004858	intermolecular recognition site; other site
1218933004859	dimerization interface [polypeptide binding]; other site
1218933004860	outer membrane receptor FepA; Provisional; Region: PRK13528
1218933004861	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933004862	N-terminal plug; other site
1218933004863	ligand-binding site [chemical binding]; other site
1218933004864	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1218933004865	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1218933004866	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
1218933004867	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1218933004868	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933004869	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1218933004870	putative substrate translocation pore; other site
1218933004871	putative S-transferase; Provisional; Region: PRK11752
1218933004872	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1218933004873	C-terminal domain interface [polypeptide binding]; other site
1218933004874	GSH binding site (G-site) [chemical binding]; other site
1218933004875	dimer interface [polypeptide binding]; other site
1218933004876	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
1218933004877	dimer interface [polypeptide binding]; other site
1218933004878	N-terminal domain interface [polypeptide binding]; other site
1218933004879	active site
1218933004880	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1218933004881	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1218933004882	NAD binding site [chemical binding]; other site
1218933004883	substrate binding site [chemical binding]; other site
1218933004884	putative active site [active]
1218933004885	Predicted transcriptional regulators [Transcription]; Region: COG1733
1218933004886	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1218933004887	dimerization interface [polypeptide binding]; other site
1218933004888	putative DNA binding site [nucleotide binding]; other site
1218933004889	putative Zn2+ binding site [ion binding]; other site
1218933004890	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
1218933004891	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1218933004892	non-specific DNA binding site [nucleotide binding]; other site
1218933004893	salt bridge; other site
1218933004894	sequence-specific DNA binding site [nucleotide binding]; other site
1218933004895	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1218933004896	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1218933004897	tetramer interface [polypeptide binding]; other site
1218933004898	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933004899	catalytic residue [active]
1218933004900	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1218933004901	dimerization interface [polypeptide binding]; other site
1218933004902	putative DNA binding site [nucleotide binding]; other site
1218933004903	putative Zn2+ binding site [ion binding]; other site
1218933004904	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933004905	putative substrate translocation pore; other site
1218933004906	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1218933004907	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
1218933004908	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781
1218933004909	DNA binding residues [nucleotide binding]
1218933004910	putative dimer interface [polypeptide binding]; other site
1218933004911	putative metal binding residues [ion binding]; other site
1218933004912	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1218933004913	beta-galactosidase; Region: BGL; TIGR03356
1218933004914	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
1218933004915	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1218933004916	TPR motif; other site
1218933004917	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1218933004918	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1218933004919	binding surface
1218933004920	TPR motif; other site
1218933004921	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1218933004922	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1218933004923	Tetratricopeptide repeat; Region: TPR_10; cl17452
1218933004924	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1218933004925	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1218933004926	binding surface
1218933004927	TPR motif; other site
1218933004928	TPR repeat; Region: TPR_11; pfam13414
1218933004929	TPR repeat; Region: TPR_11; pfam13414
1218933004930	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1218933004931	binding surface
1218933004932	TPR motif; other site
1218933004933	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1218933004934	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1218933004935	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1218933004936	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1218933004937	binding surface
1218933004938	TPR motif; other site
1218933004939	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1218933004940	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1218933004941	binding surface
1218933004942	TPR motif; other site
1218933004943	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1218933004944	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1218933004945	DNA-binding site [nucleotide binding]; DNA binding site
1218933004946	RNA-binding motif; other site
1218933004947	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122
1218933004948	methionine synthase; Provisional; Region: PRK01207
1218933004949	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1218933004950	substrate binding site [chemical binding]; other site
1218933004951	THF binding site; other site
1218933004952	zinc-binding site [ion binding]; other site
1218933004953	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
1218933004954	Protein of unknown function (DUF2543); Region: DUF2543; pfam10820
1218933004955	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1218933004956	putative active site pocket [active]
1218933004957	dimerization interface [polypeptide binding]; other site
1218933004958	putative catalytic residue [active]
1218933004959	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
1218933004960	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1218933004961	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1218933004962	transcriptional regulator MirA; Provisional; Region: PRK15043
1218933004963	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
1218933004964	DNA binding residues [nucleotide binding]
1218933004965	SnoaL-like domain; Region: SnoaL_2; pfam12680
1218933004966	short chain dehydrogenase; Provisional; Region: PRK06101
1218933004967	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1218933004968	NAD(P) binding site [chemical binding]; other site
1218933004969	active site
1218933004970	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
1218933004971	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1218933004972	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
1218933004973	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1218933004974	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933004975	S-adenosylmethionine binding site [chemical binding]; other site
1218933004976	Protein of unknown function (DUF2878); Region: DUF2878; pfam11086
1218933004977	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
1218933004978	Protein of unknown function (DUF523); Region: DUF523; pfam04463
1218933004979	Uncharacterized conserved protein [Function unknown]; Region: COG3272
1218933004980	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
1218933004981	Transposase; Region: HTH_Tnp_1; pfam01527
1218933004982	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
1218933004983	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1218933004984	ATP binding site [chemical binding]; other site
1218933004985	putative Mg++ binding site [ion binding]; other site
1218933004986	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1218933004987	nucleotide binding region [chemical binding]; other site
1218933004988	ATP-binding site [chemical binding]; other site
1218933004989	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
1218933004990	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1218933004991	Domain of unknown function (DUF4016); Region: DUF4016; pfam13208
1218933004992	tellurite resistance protein terB; Region: terB; cd07176
1218933004993	putative metal binding site [ion binding]; other site
1218933004994	Post-segregation antitoxin CcdA; Region: CcdA; pfam07362
1218933004995	CcdB protein; Region: CcdB; cl03380
1218933004996	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
1218933004997	DgsA anti-repressor MtfA; Provisional; Region: PRK15410
1218933004998	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
1218933004999	Proteolipid membrane potential modulator; Region: Pmp3; cl00431
1218933005000	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1218933005001	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1218933005002	metal binding site [ion binding]; metal-binding site
1218933005003	active site
1218933005004	I-site; other site
1218933005005	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1218933005006	putative lipid kinase; Reviewed; Region: PRK13057
1218933005007	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1218933005008	dimer interface [polypeptide binding]; other site
1218933005009	FMN binding site [chemical binding]; other site
1218933005010	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
1218933005011	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1218933005012	ATP binding site [chemical binding]; other site
1218933005013	substrate interface [chemical binding]; other site
1218933005014	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
1218933005015	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1218933005016	dimer interface [polypeptide binding]; other site
1218933005017	putative functional site; other site
1218933005018	putative MPT binding site; other site
1218933005019	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
1218933005020	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933005021	Walker A/P-loop; other site
1218933005022	ATP binding site [chemical binding]; other site
1218933005023	Q-loop/lid; other site
1218933005024	ABC transporter signature motif; other site
1218933005025	Walker B; other site
1218933005026	D-loop; other site
1218933005027	H-loop/switch region; other site
1218933005028	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1218933005029	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933005030	Walker A/P-loop; other site
1218933005031	ATP binding site [chemical binding]; other site
1218933005032	Q-loop/lid; other site
1218933005033	ABC transporter signature motif; other site
1218933005034	Walker B; other site
1218933005035	D-loop; other site
1218933005036	H-loop/switch region; other site
1218933005037	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1218933005038	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
1218933005039	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
1218933005040	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
1218933005041	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933005042	dimer interface [polypeptide binding]; other site
1218933005043	conserved gate region; other site
1218933005044	putative PBP binding loops; other site
1218933005045	ABC-ATPase subunit interface; other site
1218933005046	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
1218933005047	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1218933005048	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933005049	dimer interface [polypeptide binding]; other site
1218933005050	conserved gate region; other site
1218933005051	putative PBP binding loops; other site
1218933005052	ABC-ATPase subunit interface; other site
1218933005053	malate dehydrogenase; Provisional; Region: PRK13529
1218933005054	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1218933005055	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1218933005056	NAD(P) binding site [chemical binding]; other site
1218933005057	cytidine deaminase; Provisional; Region: PRK09027
1218933005058	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1218933005059	active site
1218933005060	catalytic motif [active]
1218933005061	Zn binding site [ion binding]; other site
1218933005062	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1218933005063	active site
1218933005064	catalytic motif [active]
1218933005065	Zn binding site [ion binding]; other site
1218933005066	hypothetical protein; Provisional; Region: PRK10711
1218933005067	hypothetical protein; Provisional; Region: PRK01821
1218933005068	Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302
1218933005069	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
1218933005070	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1218933005071	inhibitor-cofactor binding pocket; inhibition site
1218933005072	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933005073	catalytic residue [active]
1218933005074	biotin synthase; Provisional; Region: PRK15108
1218933005075	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1218933005076	FeS/SAM binding site; other site
1218933005077	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
1218933005078	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
1218933005079	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1218933005080	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1218933005081	catalytic residue [active]
1218933005082	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1218933005083	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933005084	S-adenosylmethionine binding site [chemical binding]; other site
1218933005085	AAA domain; Region: AAA_26; pfam13500
1218933005086	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1218933005087	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
1218933005088	ADP binding site [chemical binding]; other site
1218933005089	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
1218933005090	excinuclease ABC subunit B; Provisional; Region: PRK05298
1218933005091	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1218933005092	ATP binding site [chemical binding]; other site
1218933005093	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1218933005094	nucleotide binding region [chemical binding]; other site
1218933005095	ATP-binding site [chemical binding]; other site
1218933005096	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1218933005097	UvrB/uvrC motif; Region: UVR; pfam02151
1218933005098	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1218933005099	active site
1218933005100	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1218933005101	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1218933005102	putative substrate binding pocket [chemical binding]; other site
1218933005103	dimer interface [polypeptide binding]; other site
1218933005104	phosphate binding site [ion binding]; other site
1218933005105	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1218933005106	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1218933005107	FeS/SAM binding site; other site
1218933005108	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1218933005109	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1218933005110	MPT binding site; other site
1218933005111	trimer interface [polypeptide binding]; other site
1218933005112	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1218933005113	trimer interface [polypeptide binding]; other site
1218933005114	dimer interface [polypeptide binding]; other site
1218933005115	putative active site [active]
1218933005116	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1218933005117	MoaE interaction surface [polypeptide binding]; other site
1218933005118	MoeB interaction surface [polypeptide binding]; other site
1218933005119	thiocarboxylated glycine; other site
1218933005120	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1218933005121	MoaE homodimer interface [polypeptide binding]; other site
1218933005122	MoaD interaction [polypeptide binding]; other site
1218933005123	active site residues [active]
1218933005124	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1218933005125	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1218933005126	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1218933005127	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1218933005128	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1218933005129	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
1218933005130	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1218933005131	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1218933005132	Walker A/P-loop; other site
1218933005133	ATP binding site [chemical binding]; other site
1218933005134	Q-loop/lid; other site
1218933005135	ABC transporter signature motif; other site
1218933005136	Walker B; other site
1218933005137	D-loop; other site
1218933005138	H-loop/switch region; other site
1218933005139	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1218933005140	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1218933005141	Walker A/P-loop; other site
1218933005142	ATP binding site [chemical binding]; other site
1218933005143	Q-loop/lid; other site
1218933005144	ABC transporter signature motif; other site
1218933005145	Walker B; other site
1218933005146	D-loop; other site
1218933005147	H-loop/switch region; other site
1218933005148	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
1218933005149	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1218933005150	HlyD family secretion protein; Region: HlyD_3; pfam13437
1218933005151	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1218933005152	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933005153	N-terminal plug; other site
1218933005154	ligand-binding site [chemical binding]; other site
1218933005155	iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411
1218933005156	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1218933005157	siderophore binding site; other site
1218933005158	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1218933005159	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1218933005160	ABC-ATPase subunit  interface; other site
1218933005161	dimer interface [polypeptide binding]; other site
1218933005162	putative PBP binding regions; other site
1218933005163	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1218933005164	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1218933005165	ABC-ATPase subunit  interface; other site
1218933005166	dimer interface [polypeptide binding]; other site
1218933005167	putative PBP binding regions; other site
1218933005168	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1218933005169	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1218933005170	Walker A/P-loop; other site
1218933005171	ATP binding site [chemical binding]; other site
1218933005172	Q-loop/lid; other site
1218933005173	ABC transporter signature motif; other site
1218933005174	Walker B; other site
1218933005175	D-loop; other site
1218933005176	H-loop/switch region; other site
1218933005177	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1218933005178	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
1218933005179	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
1218933005180	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
1218933005181	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1218933005182	ATP binding site [chemical binding]; other site
1218933005183	Mg++ binding site [ion binding]; other site
1218933005184	motif III; other site
1218933005185	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1218933005186	nucleotide binding region [chemical binding]; other site
1218933005187	ATP-binding site [chemical binding]; other site
1218933005188	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1218933005189	EamA-like transporter family; Region: EamA; pfam00892
1218933005190	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933005191	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1218933005192	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933005193	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
1218933005194	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1218933005195	metal binding site [ion binding]; metal-binding site
1218933005196	dimer interface [polypeptide binding]; other site
1218933005197	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1218933005198	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1218933005199	peptide binding site [polypeptide binding]; other site
1218933005200	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
1218933005201	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
1218933005202	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1218933005203	FMN binding site [chemical binding]; other site
1218933005204	active site
1218933005205	catalytic residues [active]
1218933005206	substrate binding site [chemical binding]; other site
1218933005207	S-methylmethionine transporter; Provisional; Region: PRK11387
1218933005208	homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485
1218933005209	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1218933005210	aminopeptidase B; Provisional; Region: PRK05015
1218933005211	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
1218933005212	putative active site [active]
1218933005213	putative metal binding residues [ion binding]; other site
1218933005214	signature motif; other site
1218933005215	putative triphosphate binding site [ion binding]; other site
1218933005216	dimer interface [polypeptide binding]; other site
1218933005217	FMN-binding domain; Region: FMN_bind; cl01081
1218933005218	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
1218933005219	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1218933005220	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
1218933005221	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1218933005222	putative C-terminal domain interface [polypeptide binding]; other site
1218933005223	putative GSH binding site (G-site) [chemical binding]; other site
1218933005224	putative dimer interface [polypeptide binding]; other site
1218933005225	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
1218933005226	putative substrate binding pocket (H-site) [chemical binding]; other site
1218933005227	putative N-terminal domain interface [polypeptide binding]; other site
1218933005228	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
1218933005229	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1218933005230	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1218933005231	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
1218933005232	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
1218933005233	active site
1218933005234	metal binding site [ion binding]; metal-binding site
1218933005235	nudix motif; other site
1218933005236	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1218933005237	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1218933005238	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1218933005239	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
1218933005240	DEAD_2; Region: DEAD_2; pfam06733
1218933005241	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1218933005242	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
1218933005243	active site
1218933005244	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1218933005245	Protease inhibitor Inh; Region: Inh; pfam02974
1218933005246	type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842
1218933005247	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
1218933005248	Walker A/P-loop; other site
1218933005249	ATP binding site [chemical binding]; other site
1218933005250	Q-loop/lid; other site
1218933005251	ABC transporter signature motif; other site
1218933005252	Walker B; other site
1218933005253	D-loop; other site
1218933005254	H-loop/switch region; other site
1218933005255	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1218933005256	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1218933005257	HlyD family secretion protein; Region: HlyD_3; pfam13437
1218933005258	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1218933005259	Protein of unknown function (DUF4063); Region: DUF4063; pfam13272
1218933005260	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1218933005261	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1218933005262	catalytic residue [active]
1218933005263	Gp37 protein; Region: Gp37; pfam09646
1218933005264	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
1218933005265	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
1218933005266	Phage tail tube protein FII; Region: Phage_tube; cl01390
1218933005267	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1218933005268	catalytic loop [active]
1218933005269	iron binding site [ion binding]; other site
1218933005270	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
1218933005271	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
1218933005272	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
1218933005273	Phage Tail Protein X; Region: Phage_tail_X; cl02088
1218933005274	Phage protein D [General function prediction only]; Region: COG3500
1218933005275	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
1218933005276	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
1218933005277	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
1218933005278	Baseplate J-like protein; Region: Baseplate_J; cl01294
1218933005279	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684
1218933005280	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
1218933005281	glycosyl transferase family protein; Provisional; Region: PRK08136
1218933005282	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1218933005283	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
1218933005284	Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258
1218933005285	active site
1218933005286	Zn binding site [ion binding]; other site
1218933005287	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
1218933005288	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1218933005289	Walker A/P-loop; other site
1218933005290	ATP binding site [chemical binding]; other site
1218933005291	Q-loop/lid; other site
1218933005292	ABC transporter signature motif; other site
1218933005293	Walker B; other site
1218933005294	D-loop; other site
1218933005295	H-loop/switch region; other site
1218933005296	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1218933005297	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933005298	dimer interface [polypeptide binding]; other site
1218933005299	conserved gate region; other site
1218933005300	putative PBP binding loops; other site
1218933005301	ABC-ATPase subunit interface; other site
1218933005302	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
1218933005303	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1218933005304	substrate binding pocket [chemical binding]; other site
1218933005305	membrane-bound complex binding site; other site
1218933005306	hinge residues; other site
1218933005307	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1218933005308	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1218933005309	dimerization interface [polypeptide binding]; other site
1218933005310	DPS ferroxidase diiron center [ion binding]; other site
1218933005311	ion pore; other site
1218933005312	topology modulation protein; Reviewed; Region: PRK08118
1218933005313	AAA domain; Region: AAA_17; pfam13207
1218933005314	threonine and homoserine efflux system; Provisional; Region: PRK10532
1218933005315	EamA-like transporter family; Region: EamA; pfam00892
1218933005316	outer membrane protein X; Provisional; Region: ompX; PRK09408
1218933005317	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1218933005318	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933005319	putative substrate translocation pore; other site
1218933005320	MATE family multidrug exporter; Provisional; Region: PRK10189
1218933005321	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
1218933005322	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1218933005323	active site residue [active]
1218933005324	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
1218933005325	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
1218933005326	Domain of unknown function (DUF3315); Region: DUF3315; cl02275
1218933005327	RelB antitoxin; Region: RelB; cl01171
1218933005328	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
1218933005329	Predicted transcriptional regulator [Transcription]; Region: COG3905
1218933005330	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
1218933005331	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778
1218933005332	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
1218933005333	active site
1218933005334	metal binding site [ion binding]; metal-binding site
1218933005335	interdomain interaction site; other site
1218933005336	Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519
1218933005337	Domain of unknown function (DUF3950); Region: DUF3950; pfam13132
1218933005338	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
1218933005339	integrase; Provisional; Region: PRK09692
1218933005340	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1218933005341	active site
1218933005342	Int/Topo IB signature motif; other site
1218933005343	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
1218933005344	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
1218933005345	Sulfatase; Region: Sulfatase; cl17466
1218933005346	hypothetical protein; Provisional; Region: PRK13689
1218933005347	Nucleoid-associated protein [General function prediction only]; Region: COG3081
1218933005348	nucleoid-associated protein NdpA; Validated; Region: PRK00378
1218933005349	Predicted membrane protein [Function unknown]; Region: COG3503
1218933005350	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1218933005351	5S rRNA interface [nucleotide binding]; other site
1218933005352	CTC domain interface [polypeptide binding]; other site
1218933005353	L16 interface [polypeptide binding]; other site
1218933005354	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1218933005355	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1218933005356	ATP binding site [chemical binding]; other site
1218933005357	putative Mg++ binding site [ion binding]; other site
1218933005358	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1218933005359	nucleotide binding region [chemical binding]; other site
1218933005360	ATP-binding site [chemical binding]; other site
1218933005361	Double zinc ribbon; Region: DZR; pfam12773
1218933005362	Ribosomal L40e family; Region: Ribosomal_L40e; cl00671
1218933005363	probable metal-binding protein; Region: matur_matur; TIGR03853
1218933005364	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
1218933005365	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1218933005366	RNA binding surface [nucleotide binding]; other site
1218933005367	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1218933005368	active site
1218933005369	uracil binding [chemical binding]; other site
1218933005370	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933005371	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1218933005372	putative substrate translocation pore; other site
1218933005373	hypothetical protein; Provisional; Region: PRK11835
1218933005374	microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134
1218933005375	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933005376	Walker A/P-loop; other site
1218933005377	ATP binding site [chemical binding]; other site
1218933005378	Q-loop/lid; other site
1218933005379	ABC transporter signature motif; other site
1218933005380	Walker B; other site
1218933005381	D-loop; other site
1218933005382	H-loop/switch region; other site
1218933005383	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1218933005384	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933005385	Walker A/P-loop; other site
1218933005386	ATP binding site [chemical binding]; other site
1218933005387	Q-loop/lid; other site
1218933005388	ABC transporter signature motif; other site
1218933005389	Walker B; other site
1218933005390	D-loop; other site
1218933005391	H-loop/switch region; other site
1218933005392	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
1218933005393	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1218933005394	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933005395	dimer interface [polypeptide binding]; other site
1218933005396	conserved gate region; other site
1218933005397	putative PBP binding loops; other site
1218933005398	ABC-ATPase subunit interface; other site
1218933005399	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
1218933005400	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933005401	dimer interface [polypeptide binding]; other site
1218933005402	conserved gate region; other site
1218933005403	putative PBP binding loops; other site
1218933005404	ABC-ATPase subunit interface; other site
1218933005405	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1218933005406	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
1218933005407	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
1218933005408	NlpC/P60 family; Region: NLPC_P60; pfam00877
1218933005409	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1218933005410	active site
1218933005411	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1218933005412	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1218933005413	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1218933005414	elongation factor P; Provisional; Region: PRK04542
1218933005415	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1218933005416	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1218933005417	RNA binding site [nucleotide binding]; other site
1218933005418	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1218933005419	RNA binding site [nucleotide binding]; other site
1218933005420	sugar efflux transporter B; Provisional; Region: PRK15011
1218933005421	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933005422	putative substrate translocation pore; other site
1218933005423	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
1218933005424	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1218933005425	active site
1218933005426	phosphorylation site [posttranslational modification]
1218933005427	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1218933005428	dimerization domain swap beta strand [polypeptide binding]; other site
1218933005429	regulatory protein interface [polypeptide binding]; other site
1218933005430	active site
1218933005431	regulatory phosphorylation site [posttranslational modification]; other site
1218933005432	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1218933005433	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1218933005434	putative substrate binding site [chemical binding]; other site
1218933005435	putative ATP binding site [chemical binding]; other site
1218933005436	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
1218933005437	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
1218933005438	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1218933005439	active site
1218933005440	P-loop; other site
1218933005441	phosphorylation site [posttranslational modification]
1218933005442	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
1218933005443	endonuclease IV; Provisional; Region: PRK01060
1218933005444	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1218933005445	AP (apurinic/apyrimidinic) site pocket; other site
1218933005446	DNA interaction; other site
1218933005447	Metal-binding active site; metal-binding site
1218933005448	Predicted membrane protein [Function unknown]; Region: COG2855
1218933005449	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
1218933005450	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933005451	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1218933005452	putative dimerization interface [polypeptide binding]; other site
1218933005453	lysine transporter; Provisional; Region: PRK10836
1218933005454	bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486
1218933005455	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933005456	N-terminal plug; other site
1218933005457	ligand-binding site [chemical binding]; other site
1218933005458	glycerate dehydrogenase; Provisional; Region: PRK06932
1218933005459	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
1218933005460	putative ligand binding site [chemical binding]; other site
1218933005461	putative NAD binding site [chemical binding]; other site
1218933005462	catalytic site [active]
1218933005463	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1218933005464	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1218933005465	TM-ABC transporter signature motif; other site
1218933005466	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1218933005467	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1218933005468	Walker A/P-loop; other site
1218933005469	ATP binding site [chemical binding]; other site
1218933005470	Q-loop/lid; other site
1218933005471	ABC transporter signature motif; other site
1218933005472	Walker B; other site
1218933005473	D-loop; other site
1218933005474	H-loop/switch region; other site
1218933005475	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1218933005476	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1218933005477	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
1218933005478	putative active site [active]
1218933005479	metal binding site [ion binding]; metal-binding site
1218933005480	KTSC domain; Region: KTSC; pfam13619
1218933005481	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1218933005482	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1218933005483	putative C-terminal domain interface [polypeptide binding]; other site
1218933005484	putative GSH binding site (G-site) [chemical binding]; other site
1218933005485	putative dimer interface [polypeptide binding]; other site
1218933005486	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
1218933005487	putative N-terminal domain interface [polypeptide binding]; other site
1218933005488	putative dimer interface [polypeptide binding]; other site
1218933005489	putative substrate binding pocket (H-site) [chemical binding]; other site
1218933005490	S-formylglutathione hydrolase; Region: PLN02442
1218933005491	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
1218933005492	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
1218933005493	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
1218933005494	substrate binding site [chemical binding]; other site
1218933005495	catalytic Zn binding site [ion binding]; other site
1218933005496	NAD binding site [chemical binding]; other site
1218933005497	structural Zn binding site [ion binding]; other site
1218933005498	dimer interface [polypeptide binding]; other site
1218933005499	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933005500	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933005501	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
1218933005502	putative dimerization interface [polypeptide binding]; other site
1218933005503	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933005504	dimer interface [polypeptide binding]; other site
1218933005505	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1218933005506	putative CheW interface [polypeptide binding]; other site
1218933005507	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
1218933005508	active site
1218933005509	hypothetical protein; Provisional; Region: PRK10835
1218933005510	Predicted membrane protein [Function unknown]; Region: COG2311
1218933005511	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1218933005512	putative active site [active]
1218933005513	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
1218933005514	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1218933005515	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1218933005516	FeS/SAM binding site; other site
1218933005517	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
1218933005518	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
1218933005519	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1218933005520	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
1218933005521	putative C-terminal domain interface [polypeptide binding]; other site
1218933005522	putative GSH binding site (G-site) [chemical binding]; other site
1218933005523	putative dimer interface [polypeptide binding]; other site
1218933005524	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
1218933005525	putative N-terminal domain interface [polypeptide binding]; other site
1218933005526	putative dimer interface [polypeptide binding]; other site
1218933005527	putative substrate binding pocket (H-site) [chemical binding]; other site
1218933005528	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1218933005529	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1218933005530	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1218933005531	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1218933005532	Walker A/P-loop; other site
1218933005533	ATP binding site [chemical binding]; other site
1218933005534	Q-loop/lid; other site
1218933005535	ABC transporter signature motif; other site
1218933005536	Walker B; other site
1218933005537	D-loop; other site
1218933005538	H-loop/switch region; other site
1218933005539	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1218933005540	NIL domain; Region: NIL; pfam09383
1218933005541	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933005542	dimer interface [polypeptide binding]; other site
1218933005543	conserved gate region; other site
1218933005544	ABC-ATPase subunit interface; other site
1218933005545	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1218933005546	D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001
1218933005547	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1218933005548	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
1218933005549	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1218933005550	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1218933005551	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1218933005552	intersubunit interface [polypeptide binding]; other site
1218933005553	active site
1218933005554	catalytic residue [active]
1218933005555	putative transporter; Provisional; Region: PRK04972
1218933005556	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1218933005557	TrkA-C domain; Region: TrkA_C; pfam02080
1218933005558	TrkA-C domain; Region: TrkA_C; pfam02080
1218933005559	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
1218933005560	Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045
1218933005561	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
1218933005562	GSH binding site [chemical binding]; other site
1218933005563	catalytic residues [active]
1218933005564	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1218933005565	dimer interface [polypeptide binding]; other site
1218933005566	FMN binding site [chemical binding]; other site
1218933005567	NADPH bind site [chemical binding]; other site
1218933005568	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
1218933005569	RimK-like ATP-grasp domain; Region: RimK; pfam08443
1218933005570	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1218933005571	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
1218933005572	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1218933005573	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
1218933005574	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1218933005575	Walker A/P-loop; other site
1218933005576	ATP binding site [chemical binding]; other site
1218933005577	Q-loop/lid; other site
1218933005578	ABC transporter signature motif; other site
1218933005579	Walker B; other site
1218933005580	D-loop; other site
1218933005581	H-loop/switch region; other site
1218933005582	TOBE domain; Region: TOBE_2; pfam08402
1218933005583	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1218933005584	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933005585	dimer interface [polypeptide binding]; other site
1218933005586	conserved gate region; other site
1218933005587	putative PBP binding loops; other site
1218933005588	ABC-ATPase subunit interface; other site
1218933005589	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1218933005590	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933005591	dimer interface [polypeptide binding]; other site
1218933005592	conserved gate region; other site
1218933005593	putative PBP binding loops; other site
1218933005594	ABC-ATPase subunit interface; other site
1218933005595	Protein of unknown function (DUF2593); Region: DUF2593; pfam10767
1218933005596	23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522
1218933005597	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933005598	S-adenosylmethionine binding site [chemical binding]; other site
1218933005599	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
1218933005600	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1218933005601	substrate binding pocket [chemical binding]; other site
1218933005602	membrane-bound complex binding site; other site
1218933005603	hinge residues; other site
1218933005604	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933005605	dimer interface [polypeptide binding]; other site
1218933005606	conserved gate region; other site
1218933005607	putative PBP binding loops; other site
1218933005608	ABC-ATPase subunit interface; other site
1218933005609	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1218933005610	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933005611	dimer interface [polypeptide binding]; other site
1218933005612	conserved gate region; other site
1218933005613	putative PBP binding loops; other site
1218933005614	ABC-ATPase subunit interface; other site
1218933005615	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
1218933005616	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1218933005617	substrate binding pocket [chemical binding]; other site
1218933005618	membrane-bound complex binding site; other site
1218933005619	hinge residues; other site
1218933005620	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
1218933005621	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933005622	Walker A/P-loop; other site
1218933005623	ATP binding site [chemical binding]; other site
1218933005624	Q-loop/lid; other site
1218933005625	ABC transporter signature motif; other site
1218933005626	Walker B; other site
1218933005627	D-loop; other site
1218933005628	H-loop/switch region; other site
1218933005629	hypothetical protein; Provisional; Region: PRK02877
1218933005630	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1218933005631	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1218933005632	amidase catalytic site [active]
1218933005633	Zn binding residues [ion binding]; other site
1218933005634	substrate binding site [chemical binding]; other site
1218933005635	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1218933005636	atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245
1218933005637	putative NAD(P) binding site [chemical binding]; other site
1218933005638	putative active site [active]
1218933005639	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
1218933005640	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
1218933005641	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
1218933005642	FAD binding pocket [chemical binding]; other site
1218933005643	FAD binding motif [chemical binding]; other site
1218933005644	phosphate binding motif [ion binding]; other site
1218933005645	beta-alpha-beta structure motif; other site
1218933005646	NAD binding pocket [chemical binding]; other site
1218933005647	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1218933005648	catalytic loop [active]
1218933005649	iron binding site [ion binding]; other site
1218933005650	hybrid cluster protein; Provisional; Region: PRK05290
1218933005651	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1218933005652	ACS interaction site; other site
1218933005653	CODH interaction site; other site
1218933005654	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
1218933005655	hybrid metal cluster; other site
1218933005656	Predicted membrane protein [Function unknown]; Region: COG2431
1218933005657	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
1218933005658	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
1218933005659	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
1218933005660	putative active site [active]
1218933005661	putative metal-binding site [ion binding]; other site
1218933005662	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1218933005663	DNA-binding site [nucleotide binding]; DNA binding site
1218933005664	RNA-binding motif; other site
1218933005665	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
1218933005666	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
1218933005667	Clp amino terminal domain; Region: Clp_N; pfam02861
1218933005668	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933005669	Walker A motif; other site
1218933005670	ATP binding site [chemical binding]; other site
1218933005671	Walker B motif; other site
1218933005672	arginine finger; other site
1218933005673	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933005674	Walker A motif; other site
1218933005675	ATP binding site [chemical binding]; other site
1218933005676	Walker B motif; other site
1218933005677	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1218933005678	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1218933005679	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1218933005680	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1218933005681	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1218933005682	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933005683	homodimer interface [polypeptide binding]; other site
1218933005684	catalytic residue [active]
1218933005685	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1218933005686	rRNA binding site [nucleotide binding]; other site
1218933005687	predicted 30S ribosome binding site; other site
1218933005688	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
1218933005689	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
1218933005690	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1218933005691	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
1218933005692	Walker A/P-loop; other site
1218933005693	ATP binding site [chemical binding]; other site
1218933005694	Q-loop/lid; other site
1218933005695	ABC transporter signature motif; other site
1218933005696	Walker B; other site
1218933005697	D-loop; other site
1218933005698	H-loop/switch region; other site
1218933005699	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
1218933005700	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1218933005701	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933005702	Walker A/P-loop; other site
1218933005703	ATP binding site [chemical binding]; other site
1218933005704	Q-loop/lid; other site
1218933005705	ABC transporter signature motif; other site
1218933005706	Walker B; other site
1218933005707	D-loop; other site
1218933005708	H-loop/switch region; other site
1218933005709	thioredoxin reductase; Provisional; Region: PRK10262
1218933005710	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1218933005711	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1218933005712	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
1218933005713	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1218933005714	putative DNA binding site [nucleotide binding]; other site
1218933005715	putative Zn2+ binding site [ion binding]; other site
1218933005716	AsnC family; Region: AsnC_trans_reg; pfam01037
1218933005717	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1218933005718	DNA translocase FtsK; Provisional; Region: PRK10263
1218933005719	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1218933005720	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1218933005721	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
1218933005722	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
1218933005723	recombination factor protein RarA; Reviewed; Region: PRK13342
1218933005724	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933005725	Walker A motif; other site
1218933005726	ATP binding site [chemical binding]; other site
1218933005727	Walker B motif; other site
1218933005728	arginine finger; other site
1218933005729	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1218933005730	seryl-tRNA synthetase; Provisional; Region: PRK05431
1218933005731	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1218933005732	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1218933005733	dimer interface [polypeptide binding]; other site
1218933005734	active site
1218933005735	motif 1; other site
1218933005736	motif 2; other site
1218933005737	motif 3; other site
1218933005738	putative MFS family transporter protein; Provisional; Region: PRK03633
1218933005739	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933005740	putative substrate translocation pore; other site
1218933005741	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933005742	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933005743	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1218933005744	dimerization interface [polypeptide binding]; other site
1218933005745	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1218933005746	Na binding site [ion binding]; other site
1218933005747	Protein of unknown function (DUF917); Region: DUF917; pfam06032
1218933005748	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1218933005749	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1218933005750	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1218933005751	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
1218933005752	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1218933005753	FeS/SAM binding site; other site
1218933005754	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1218933005755	Pyruvate formate lyase 1; Region: PFL1; cd01678
1218933005756	coenzyme A binding site [chemical binding]; other site
1218933005757	active site
1218933005758	catalytic residues [active]
1218933005759	glycine loop; other site
1218933005760	formate transporter; Provisional; Region: PRK10805
1218933005761	uncharacterized domain; Region: TIGR00702
1218933005762	YcaO-like family; Region: YcaO; pfam02624
1218933005763	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
1218933005764	homodimer interface [polypeptide binding]; other site
1218933005765	substrate-cofactor binding pocket; other site
1218933005766	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933005767	catalytic residue [active]
1218933005768	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1218933005769	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1218933005770	hinge; other site
1218933005771	active site
1218933005772	cytidylate kinase; Provisional; Region: cmk; PRK00023
1218933005773	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1218933005774	CMP-binding site; other site
1218933005775	The sites determining sugar specificity; other site
1218933005776	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
1218933005777	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1218933005778	RNA binding site [nucleotide binding]; other site
1218933005779	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1218933005780	RNA binding site [nucleotide binding]; other site
1218933005781	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1218933005782	RNA binding site [nucleotide binding]; other site
1218933005783	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
1218933005784	RNA binding site [nucleotide binding]; other site
1218933005785	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1218933005786	RNA binding site [nucleotide binding]; other site
1218933005787	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
1218933005788	RNA binding site [nucleotide binding]; other site
1218933005789	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1218933005790	IHF dimer interface [polypeptide binding]; other site
1218933005791	IHF - DNA interface [nucleotide binding]; other site
1218933005792	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1218933005793	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1218933005794	active site
1218933005795	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
1218933005796	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1218933005797	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1218933005798	metal binding site [ion binding]; metal-binding site
1218933005799	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1218933005800	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1218933005801	substrate binding site [chemical binding]; other site
1218933005802	glutamase interaction surface [polypeptide binding]; other site
1218933005803	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1218933005804	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1218933005805	catalytic residues [active]
1218933005806	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
1218933005807	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1218933005808	putative active site [active]
1218933005809	oxyanion strand; other site
1218933005810	catalytic triad [active]
1218933005811	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
1218933005812	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1218933005813	active site
1218933005814	motif I; other site
1218933005815	motif II; other site
1218933005816	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1218933005817	putative active site pocket [active]
1218933005818	4-fold oligomerization interface [polypeptide binding]; other site
1218933005819	metal binding residues [ion binding]; metal-binding site
1218933005820	3-fold/trimer interface [polypeptide binding]; other site
1218933005821	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
1218933005822	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1218933005823	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933005824	homodimer interface [polypeptide binding]; other site
1218933005825	catalytic residue [active]
1218933005826	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1218933005827	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1218933005828	NAD binding site [chemical binding]; other site
1218933005829	dimerization interface [polypeptide binding]; other site
1218933005830	product binding site; other site
1218933005831	substrate binding site [chemical binding]; other site
1218933005832	zinc binding site [ion binding]; other site
1218933005833	catalytic residues [active]
1218933005834	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
1218933005835	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
1218933005836	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
1218933005837	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1218933005838	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
1218933005839	putative NAD(P) binding site [chemical binding]; other site
1218933005840	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933005841	dimerization interface [polypeptide binding]; other site
1218933005842	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1218933005843	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933005844	dimer interface [polypeptide binding]; other site
1218933005845	putative CheW interface [polypeptide binding]; other site
1218933005846	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933005847	dimerization interface [polypeptide binding]; other site
1218933005848	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1218933005849	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933005850	dimer interface [polypeptide binding]; other site
1218933005851	putative CheW interface [polypeptide binding]; other site
1218933005852	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1218933005853	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933005854	active site
1218933005855	phosphorylation site [posttranslational modification]
1218933005856	intermolecular recognition site; other site
1218933005857	dimerization interface [polypeptide binding]; other site
1218933005858	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1218933005859	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1218933005860	PAS domain; Region: PAS; smart00091
1218933005861	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933005862	ATP binding site [chemical binding]; other site
1218933005863	Mg2+ binding site [ion binding]; other site
1218933005864	G-X-G motif; other site
1218933005865	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
1218933005866	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1218933005867	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1218933005868	[citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124
1218933005869	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
1218933005870	putative active site [active]
1218933005871	(T/H)XGH motif; other site
1218933005872	citrate lyase subunit gamma; Provisional; Region: PRK13253
1218933005873	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
1218933005874	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
1218933005875	holo-ACP synthase CitX; Region: citrate_citX; TIGR03124
1218933005876	triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125
1218933005877	Flagellar regulator YcgR; Region: YcgR; pfam07317
1218933005878	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
1218933005879	PilZ domain; Region: PilZ; pfam07238
1218933005880	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1218933005881	exonuclease I; Provisional; Region: sbcB; PRK11779
1218933005882	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
1218933005883	active site
1218933005884	catalytic site [active]
1218933005885	substrate binding site [chemical binding]; other site
1218933005886	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
1218933005887	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
1218933005888	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
1218933005889	putative ligand binding residues [chemical binding]; other site
1218933005890	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1218933005891	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1218933005892	ABC-ATPase subunit  interface; other site
1218933005893	dimer interface [polypeptide binding]; other site
1218933005894	putative PBP binding regions; other site
1218933005895	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1218933005896	ABC-ATPase subunit  interface; other site
1218933005897	dimer interface [polypeptide binding]; other site
1218933005898	putative PBP binding regions; other site
1218933005899	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
1218933005900	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1218933005901	Walker A/P-loop; other site
1218933005902	ATP binding site [chemical binding]; other site
1218933005903	Q-loop/lid; other site
1218933005904	ABC transporter signature motif; other site
1218933005905	Walker B; other site
1218933005906	D-loop; other site
1218933005907	H-loop/switch region; other site
1218933005908	hypothetical protein; Provisional; Region: PRK05423
1218933005909	ComEC family competence protein; Provisional; Region: PRK11539
1218933005910	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1218933005911	Competence protein; Region: Competence; pfam03772
1218933005912	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1218933005913	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
1218933005914	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1218933005915	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1218933005916	Walker A/P-loop; other site
1218933005917	ATP binding site [chemical binding]; other site
1218933005918	Q-loop/lid; other site
1218933005919	ABC transporter signature motif; other site
1218933005920	Walker B; other site
1218933005921	D-loop; other site
1218933005922	H-loop/switch region; other site
1218933005923	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
1218933005924	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
1218933005925	Trm112p-like protein; Region: Trm112p; cl01066
1218933005926	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1218933005927	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1218933005928	Ligand binding site; other site
1218933005929	oligomer interface; other site
1218933005930	Right handed beta helix region; Region: Beta_helix; pfam13229
1218933005931	hypothetical protein; Provisional; Region: PRK10593
1218933005932	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1218933005933	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1218933005934	putative active site [active]
1218933005935	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1218933005936	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933005937	S-adenosylmethionine binding site [chemical binding]; other site
1218933005938	condesin subunit F; Provisional; Region: PRK05260
1218933005939	condesin subunit E; Provisional; Region: PRK05256
1218933005940	cell division protein MukB; Provisional; Region: mukB; PRK04863
1218933005941	P-loop containing region of AAA domain; Region: AAA_29; cl17516
1218933005942	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
1218933005943	murein L,D-transpeptidase; Provisional; Region: PRK10594
1218933005944	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1218933005945	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1218933005946	Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181
1218933005947	active site
1218933005948	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
1218933005949	Peptidase M15; Region: Peptidase_M15_3; cl01194
1218933005950	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1218933005951	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
1218933005952	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1218933005953	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933005954	homodimer interface [polypeptide binding]; other site
1218933005955	catalytic residue [active]
1218933005956	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1218933005957	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1218933005958	trimer interface [polypeptide binding]; other site
1218933005959	eyelet of channel; other site
1218933005960	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1218933005961	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
1218933005962	putative dimer interface [polypeptide binding]; other site
1218933005963	putative anticodon binding site; other site
1218933005964	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1218933005965	homodimer interface [polypeptide binding]; other site
1218933005966	motif 1; other site
1218933005967	motif 2; other site
1218933005968	active site
1218933005969	motif 3; other site
1218933005970	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
1218933005971	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
1218933005972	active site
1218933005973	aminopeptidase N; Provisional; Region: pepN; PRK14015
1218933005974	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
1218933005975	active site
1218933005976	Zn binding site [ion binding]; other site
1218933005977	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1218933005978	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1218933005979	quinone interaction residues [chemical binding]; other site
1218933005980	active site
1218933005981	catalytic residues [active]
1218933005982	FMN binding site [chemical binding]; other site
1218933005983	substrate binding site [chemical binding]; other site
1218933005984	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
1218933005985	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
1218933005986	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
1218933005987	MOSC domain; Region: MOSC; pfam03473
1218933005988	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1218933005989	catalytic loop [active]
1218933005990	iron binding site [ion binding]; other site
1218933005991	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
1218933005992	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1218933005993	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
1218933005994	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933005995	S-adenosylmethionine binding site [chemical binding]; other site
1218933005996	ABC transporter ATPase component; Reviewed; Region: PRK11147
1218933005997	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933005998	Walker A/P-loop; other site
1218933005999	ATP binding site [chemical binding]; other site
1218933006000	Q-loop/lid; other site
1218933006001	ABC transporter signature motif; other site
1218933006002	Walker B; other site
1218933006003	D-loop; other site
1218933006004	H-loop/switch region; other site
1218933006005	ABC transporter; Region: ABC_tran_2; pfam12848
1218933006006	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1218933006007	paraquat-inducible membrane protein A; Provisional; Region: PRK15103
1218933006008	Paraquat-inducible protein A; Region: PqiA; pfam04403
1218933006009	Paraquat-inducible protein A; Region: PqiA; pfam04403
1218933006010	paraquat-inducible protein B; Provisional; Region: PRK10807
1218933006011	mce related protein; Region: MCE; pfam02470
1218933006012	mce related protein; Region: MCE; pfam02470
1218933006013	mce related protein; Region: MCE; pfam02470
1218933006014	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
1218933006015	Protein of unknown function (DUF330); Region: DUF330; pfam03886
1218933006016	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
1218933006017	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1218933006018	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933006019	dimer interface [polypeptide binding]; other site
1218933006020	putative CheW interface [polypeptide binding]; other site
1218933006021	putative hydrolase; Validated; Region: PRK09248
1218933006022	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
1218933006023	active site
1218933006024	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
1218933006025	lipoprotein; Provisional; Region: PRK10598
1218933006026	glutaredoxin 2; Provisional; Region: PRK10387
1218933006027	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
1218933006028	C-terminal domain interface [polypeptide binding]; other site
1218933006029	GSH binding site (G-site) [chemical binding]; other site
1218933006030	catalytic residues [active]
1218933006031	putative dimer interface [polypeptide binding]; other site
1218933006032	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
1218933006033	N-terminal domain interface [polypeptide binding]; other site
1218933006034	multidrug resistance protein MdtH; Provisional; Region: PRK11646
1218933006035	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933006036	putative substrate translocation pore; other site
1218933006037	ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809
1218933006038	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1218933006039	hypothetical protein; Provisional; Region: PRK11239
1218933006040	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132
1218933006041	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1218933006042	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1218933006043	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1218933006044	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1218933006045	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
1218933006046	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1218933006047	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1218933006048	active site
1218933006049	HIGH motif; other site
1218933006050	KMSK motif region; other site
1218933006051	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1218933006052	tRNA binding surface [nucleotide binding]; other site
1218933006053	anticodon binding site; other site
1218933006054	hypothetical protein; Provisional; Region: PRK11700
1218933006055	active site
1218933006056	copper homeostasis protein CutC; Provisional; Region: PRK11572
1218933006057	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1218933006058	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933006059	S-adenosylmethionine binding site [chemical binding]; other site
1218933006060	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933006061	S-adenosylmethionine binding site [chemical binding]; other site
1218933006062	Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788
1218933006063	hypothetical protein; Provisional; Region: PRK10302
1218933006064	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
1218933006065	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1218933006066	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1218933006067	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1218933006068	dimer interface [polypeptide binding]; other site
1218933006069	anticodon binding site; other site
1218933006070	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1218933006071	homodimer interface [polypeptide binding]; other site
1218933006072	motif 1; other site
1218933006073	active site
1218933006074	motif 2; other site
1218933006075	GAD domain; Region: GAD; pfam02938
1218933006076	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1218933006077	active site
1218933006078	motif 3; other site
1218933006079	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
1218933006080	nudix motif; other site
1218933006081	hypothetical protein; Validated; Region: PRK00110
1218933006082	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1218933006083	active site
1218933006084	putative DNA-binding cleft [nucleotide binding]; other site
1218933006085	dimer interface [polypeptide binding]; other site
1218933006086	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1218933006087	RuvA N terminal domain; Region: RuvA_N; pfam01330
1218933006088	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1218933006089	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1218933006090	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933006091	Walker A motif; other site
1218933006092	ATP binding site [chemical binding]; other site
1218933006093	Walker B motif; other site
1218933006094	arginine finger; other site
1218933006095	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1218933006096	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1218933006097	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1218933006098	active site
1218933006099	methionine cluster; other site
1218933006100	phosphorylation site [posttranslational modification]
1218933006101	metal binding site [ion binding]; metal-binding site
1218933006102	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1218933006103	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1218933006104	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1218933006105	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402
1218933006106	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1218933006107	ligand binding site [chemical binding]; other site
1218933006108	dimerization interface [polypeptide binding]; other site
1218933006109	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1218933006110	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1218933006111	ABC-ATPase subunit  interface; other site
1218933006112	dimer interface [polypeptide binding]; other site
1218933006113	putative PBP binding regions; other site
1218933006114	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
1218933006115	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1218933006116	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
1218933006117	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
1218933006118	metal binding site [ion binding]; metal-binding site
1218933006119	putative peptidase; Provisional; Region: PRK11649
1218933006120	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
1218933006121	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1218933006122	Peptidase family M23; Region: Peptidase_M23; pfam01551
1218933006123	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1218933006124	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1218933006125	putative acyl-acceptor binding pocket; other site
1218933006126	pyruvate kinase; Provisional; Region: PRK05826
1218933006127	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1218933006128	domain interfaces; other site
1218933006129	active site
1218933006130	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
1218933006131	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1218933006132	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1218933006133	putative active site [active]
1218933006134	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1218933006135	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1218933006136	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1218933006137	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
1218933006138	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1218933006139	active site
1218933006140	intersubunit interface [polypeptide binding]; other site
1218933006141	catalytic residue [active]
1218933006142	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1218933006143	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1218933006144	ATP-grasp domain; Region: ATP-grasp; pfam02222
1218933006145	protease 2; Provisional; Region: PRK10115
1218933006146	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1218933006147	DNA polymerase III subunit theta; Reviewed; Region: PRK10969
1218933006148	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1218933006149	Ferritin-like domain; Region: Ferritin; pfam00210
1218933006150	ferroxidase diiron center [ion binding]; other site
1218933006151	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
1218933006152	Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003
1218933006153	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1218933006154	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
1218933006155	dimer interface [polypeptide binding]; other site
1218933006156	active site
1218933006157	Int/Topo IB signature motif; other site
1218933006158	Excisionase-like protein; Region: Exc; pfam07825
1218933006159	RecT family; Region: RecT; pfam03837
1218933006160	exonuclease VIII; Reviewed; Region: PRK09709
1218933006161	Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630
1218933006162	Protein of unknown function (DUF1482); Region: DUF1482; pfam07358
1218933006163	Protein of unknown function (DUF1019); Region: DUF1019; pfam06254
1218933006164	ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020
1218933006165	primosomal protein DnaI; Provisional; Region: PRK02854
1218933006166	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1218933006167	Methyltransferase domain; Region: Methyltransf_25; pfam13649
1218933006168	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1218933006169	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1218933006170	cofactor binding site; other site
1218933006171	DNA binding site [nucleotide binding]
1218933006172	substrate interaction site [chemical binding]; other site
1218933006173	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1218933006174	NinB protein; Region: NinB; pfam05772
1218933006175	Bacteriophage Lambda NinG protein; Region: NinG; pfam05766
1218933006176	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1218933006177	active site
1218933006178	Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323
1218933006179	Lysis protein S; Region: Lysis_S; pfam04971
1218933006180	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
1218933006181	catalytic residues [active]
1218933006182	Terminase small subunit; Region: Terminase_2; cl01513
1218933006183	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
1218933006184	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
1218933006185	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
1218933006186	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
1218933006187	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834
1218933006188	Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950
1218933006189	Protein of unknown function (DUF4054); Region: DUF4054; pfam13262
1218933006190	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
1218933006191	Protein of unknown function (DUF3277); Region: DUF3277; pfam11681
1218933006192	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1218933006193	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1218933006194	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1218933006195	catalytic residue [active]
1218933006196	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
1218933006197	Baseplate J-like protein; Region: Baseplate_J; cl01294
1218933006198	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
1218933006199	Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406
1218933006200	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
1218933006201	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1218933006202	DNA-binding site [nucleotide binding]; DNA binding site
1218933006203	RNA-binding motif; other site
1218933006204	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
1218933006205	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
1218933006206	Protein of unknown function (DUF1482); Region: DUF1482; pfam07358
1218933006207	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
1218933006208	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933006209	S-adenosylmethionine binding site [chemical binding]; other site
1218933006210	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
1218933006211	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
1218933006212	mce related protein; Region: MCE; pfam02470
1218933006213	mce related protein; Region: MCE; pfam02470
1218933006214	mce related protein; Region: MCE; pfam02470
1218933006215	mce related protein; Region: MCE; pfam02470
1218933006216	mce related protein; Region: MCE; pfam02470
1218933006217	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
1218933006218	Paraquat-inducible protein A; Region: PqiA; pfam04403
1218933006219	Paraquat-inducible protein A; Region: PqiA; pfam04403
1218933006220	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1218933006221	GAF domain; Region: GAF_2; pfam13185
1218933006222	ProP expression regulator; Provisional; Region: PRK04950
1218933006223	ProQ/FINO family; Region: ProQ; smart00945
1218933006224	carboxy-terminal protease; Provisional; Region: PRK11186
1218933006225	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1218933006226	protein binding site [polypeptide binding]; other site
1218933006227	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1218933006228	Catalytic dyad [active]
1218933006229	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
1218933006230	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1218933006231	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933006232	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1218933006233	substrate binding site [chemical binding]; other site
1218933006234	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1218933006235	Helix-turn-helix domain; Region: HTH_18; pfam12833
1218933006236	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933006237	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933006238	putative substrate translocation pore; other site
1218933006239	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1218933006240	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1218933006241	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1218933006242	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1218933006243	DNA binding site [nucleotide binding]
1218933006244	active site
1218933006245	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
1218933006246	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
1218933006247	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1218933006248	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933006249	dimer interface [polypeptide binding]; other site
1218933006250	conserved gate region; other site
1218933006251	putative PBP binding loops; other site
1218933006252	ABC-ATPase subunit interface; other site
1218933006253	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1218933006254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933006255	dimer interface [polypeptide binding]; other site
1218933006256	conserved gate region; other site
1218933006257	putative PBP binding loops; other site
1218933006258	ABC-ATPase subunit interface; other site
1218933006259	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
1218933006260	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1218933006261	Walker A/P-loop; other site
1218933006262	ATP binding site [chemical binding]; other site
1218933006263	Q-loop/lid; other site
1218933006264	ABC transporter signature motif; other site
1218933006265	Walker B; other site
1218933006266	D-loop; other site
1218933006267	H-loop/switch region; other site
1218933006268	TOBE domain; Region: TOBE_2; pfam08402
1218933006269	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
1218933006270	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1218933006271	metal binding site [ion binding]; metal-binding site
1218933006272	dimer interface [polypeptide binding]; other site
1218933006273	Uncharacterized conserved protein [Function unknown]; Region: COG2850
1218933006274	sensor protein PhoQ; Provisional; Region: PRK10815
1218933006275	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
1218933006276	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
1218933006277	dimer interface [polypeptide binding]; other site
1218933006278	phosphorylation site [posttranslational modification]
1218933006279	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933006280	ATP binding site [chemical binding]; other site
1218933006281	Mg2+ binding site [ion binding]; other site
1218933006282	G-X-G motif; other site
1218933006283	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
1218933006284	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933006285	active site
1218933006286	phosphorylation site [posttranslational modification]
1218933006287	intermolecular recognition site; other site
1218933006288	dimerization interface [polypeptide binding]; other site
1218933006289	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1218933006290	DNA binding site [nucleotide binding]
1218933006291	adenylosuccinate lyase; Provisional; Region: PRK09285
1218933006292	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
1218933006293	tetramer interface [polypeptide binding]; other site
1218933006294	active site
1218933006295	putative lysogenization regulator; Reviewed; Region: PRK00218
1218933006296	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1218933006297	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
1218933006298	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
1218933006299	nudix motif; other site
1218933006300	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
1218933006301	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1218933006302	active site
1218933006303	isocitrate dehydrogenase; Validated; Region: PRK07362
1218933006304	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1218933006305	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1218933006306	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1218933006307	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1218933006308	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
1218933006309	Mor transcription activator family; Region: Mor; pfam08765
1218933006310	Predicted transcriptional regulator [Transcription]; Region: COG2932
1218933006311	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1218933006312	Catalytic site [active]
1218933006313	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1218933006314	GAF domain; Region: GAF; pfam01590
1218933006315	PAS domain S-box; Region: sensory_box; TIGR00229
1218933006316	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1218933006317	putative active site [active]
1218933006318	heme pocket [chemical binding]; other site
1218933006319	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1218933006320	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1218933006321	metal binding site [ion binding]; metal-binding site
1218933006322	active site
1218933006323	I-site; other site
1218933006324	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1218933006325	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1218933006326	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1218933006327	GAF domain; Region: GAF_3; pfam13492
1218933006328	Histidine kinase; Region: His_kinase; pfam06580
1218933006329	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933006330	ATP binding site [chemical binding]; other site
1218933006331	Mg2+ binding site [ion binding]; other site
1218933006332	G-X-G motif; other site
1218933006333	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1218933006334	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933006335	active site
1218933006336	phosphorylation site [posttranslational modification]
1218933006337	intermolecular recognition site; other site
1218933006338	dimerization interface [polypeptide binding]; other site
1218933006339	LytTr DNA-binding domain; Region: LytTR; pfam04397
1218933006340	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
1218933006341	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933006342	putative substrate translocation pore; other site
1218933006343	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1218933006344	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1218933006345	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1218933006346	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
1218933006347	putative active site [active]
1218933006348	catalytic site [active]
1218933006349	putative metal binding site [ion binding]; other site
1218933006350	oligomer interface [polypeptide binding]; other site
1218933006351	heat shock protein HtpX; Provisional; Region: PRK05457
1218933006352	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
1218933006353	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1218933006354	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
1218933006355	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1218933006356	dimerization interface [polypeptide binding]; other site
1218933006357	putative Zn2+ binding site [ion binding]; other site
1218933006358	putative DNA binding site [nucleotide binding]; other site
1218933006359	Bacterial transcriptional regulator; Region: IclR; pfam01614
1218933006360	YebO-like protein; Region: YebO; pfam13974
1218933006361	aromatic amino acid transporter; Provisional; Region: PRK10238
1218933006362	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1218933006363	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1218933006364	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
1218933006365	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1218933006366	active site
1218933006367	dimer interface [polypeptide binding]; other site
1218933006368	motif 1; other site
1218933006369	motif 2; other site
1218933006370	motif 3; other site
1218933006371	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1218933006372	anticodon binding site; other site
1218933006373	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1218933006374	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1218933006375	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1218933006376	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1218933006377	23S rRNA binding site [nucleotide binding]; other site
1218933006378	L21 binding site [polypeptide binding]; other site
1218933006379	L13 binding site [polypeptide binding]; other site
1218933006380	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1218933006381	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1218933006382	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1218933006383	dimer interface [polypeptide binding]; other site
1218933006384	motif 1; other site
1218933006385	active site
1218933006386	motif 2; other site
1218933006387	motif 3; other site
1218933006388	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1218933006389	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1218933006390	putative tRNA-binding site [nucleotide binding]; other site
1218933006391	B3/4 domain; Region: B3_4; pfam03483
1218933006392	tRNA synthetase B5 domain; Region: B5; smart00874
1218933006393	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1218933006394	dimer interface [polypeptide binding]; other site
1218933006395	motif 1; other site
1218933006396	motif 3; other site
1218933006397	motif 2; other site
1218933006398	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1218933006399	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1218933006400	IHF dimer interface [polypeptide binding]; other site
1218933006401	IHF - DNA interface [nucleotide binding]; other site
1218933006402	Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756
1218933006403	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1218933006404	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1218933006405	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1218933006406	Walker A/P-loop; other site
1218933006407	ATP binding site [chemical binding]; other site
1218933006408	Q-loop/lid; other site
1218933006409	ABC transporter signature motif; other site
1218933006410	Walker B; other site
1218933006411	D-loop; other site
1218933006412	H-loop/switch region; other site
1218933006413	aromatic amino acid exporter; Provisional; Region: PRK11689
1218933006414	EamA-like transporter family; Region: EamA; pfam00892
1218933006415	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1218933006416	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1218933006417	homodimer interface [polypeptide binding]; other site
1218933006418	NAD binding pocket [chemical binding]; other site
1218933006419	ATP binding pocket [chemical binding]; other site
1218933006420	Mg binding site [ion binding]; other site
1218933006421	active-site loop [active]
1218933006422	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
1218933006423	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
1218933006424	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1218933006425	inner membrane protein; Provisional; Region: PRK11648
1218933006426	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
1218933006427	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1218933006428	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629
1218933006429	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1218933006430	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1218933006431	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1218933006432	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933006433	Walker A/P-loop; other site
1218933006434	ATP binding site [chemical binding]; other site
1218933006435	Q-loop/lid; other site
1218933006436	ABC transporter signature motif; other site
1218933006437	Walker B; other site
1218933006438	D-loop; other site
1218933006439	H-loop/switch region; other site
1218933006440	TOBE domain; Region: TOBE; pfam03459
1218933006441	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1218933006442	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933006443	dimer interface [polypeptide binding]; other site
1218933006444	conserved gate region; other site
1218933006445	putative PBP binding loops; other site
1218933006446	ABC-ATPase subunit interface; other site
1218933006447	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933006448	dimer interface [polypeptide binding]; other site
1218933006449	conserved gate region; other site
1218933006450	putative PBP binding loops; other site
1218933006451	ABC-ATPase subunit interface; other site
1218933006452	Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917
1218933006453	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
1218933006454	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1218933006455	NADP binding site [chemical binding]; other site
1218933006456	homodimer interface [polypeptide binding]; other site
1218933006457	active site
1218933006458	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1218933006459	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
1218933006460	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1218933006461	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1218933006462	motif II; other site
1218933006463	YniB-like protein; Region: YniB; pfam14002
1218933006464	Phosphotransferase enzyme family; Region: APH; pfam01636
1218933006465	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1218933006466	active site
1218933006467	ATP binding site [chemical binding]; other site
1218933006468	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1218933006469	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1218933006470	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1218933006471	ABC-ATPase subunit  interface; other site
1218933006472	dimer interface [polypeptide binding]; other site
1218933006473	putative PBP binding regions; other site
1218933006474	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1218933006475	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1218933006476	ABC-ATPase subunit  interface; other site
1218933006477	dimer interface [polypeptide binding]; other site
1218933006478	putative PBP binding regions; other site
1218933006479	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
1218933006480	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1218933006481	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1218933006482	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1218933006483	metal binding site [ion binding]; metal-binding site
1218933006484	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1218933006485	DNA-binding site [nucleotide binding]; DNA binding site
1218933006486	RNA-binding motif; other site
1218933006487	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
1218933006488	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933006489	S-adenosylmethionine binding site [chemical binding]; other site
1218933006490	hypothetical protein; Provisional; Region: PRK11469
1218933006491	Domain of unknown function DUF; Region: DUF204; pfam02659
1218933006492	Domain of unknown function DUF; Region: DUF204; pfam02659
1218933006493	hypothetical protein; Provisional; Region: PRK02913
1218933006494	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
1218933006495	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
1218933006496	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
1218933006497	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1218933006498	active pocket/dimerization site; other site
1218933006499	active site
1218933006500	phosphorylation site [posttranslational modification]
1218933006501	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1218933006502	active site
1218933006503	phosphorylation site [posttranslational modification]
1218933006504	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1218933006505	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
1218933006506	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1218933006507	Transporter associated domain; Region: CorC_HlyC; smart01091
1218933006508	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1218933006509	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1218933006510	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1218933006511	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1218933006512	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1218933006513	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
1218933006514	active site
1218933006515	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
1218933006516	RNAase interaction site [polypeptide binding]; other site
1218933006517	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1218933006518	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1218933006519	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1218933006520	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1218933006521	putative active site [active]
1218933006522	putative CoA binding site [chemical binding]; other site
1218933006523	nudix motif; other site
1218933006524	metal binding site [ion binding]; metal-binding site
1218933006525	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
1218933006526	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1218933006527	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1218933006528	hypothetical protein; Provisional; Region: PRK05114
1218933006529	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1218933006530	homotrimer interaction site [polypeptide binding]; other site
1218933006531	putative active site [active]
1218933006532	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1218933006533	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1218933006534	DEAD_2; Region: DEAD_2; pfam06733
1218933006535	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1218933006536	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1218933006537	Glycoprotease family; Region: Peptidase_M22; pfam00814
1218933006538	Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065
1218933006539	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
1218933006540	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1218933006541	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1218933006542	acyl-activating enzyme (AAE) consensus motif; other site
1218933006543	putative AMP binding site [chemical binding]; other site
1218933006544	putative active site [active]
1218933006545	putative CoA binding site [chemical binding]; other site
1218933006546	ribonuclease D; Provisional; Region: PRK10829
1218933006547	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1218933006548	catalytic site [active]
1218933006549	putative active site [active]
1218933006550	putative substrate binding site [chemical binding]; other site
1218933006551	HRDC domain; Region: HRDC; pfam00570
1218933006552	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
1218933006553	cell division inhibitor MinD; Provisional; Region: PRK10818
1218933006554	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1218933006555	Switch I; other site
1218933006556	Switch II; other site
1218933006557	septum formation inhibitor; Reviewed; Region: minC; PRK03511
1218933006558	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
1218933006559	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1218933006560	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100
1218933006561	hypothetical protein; Provisional; Region: PRK10691
1218933006562	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1218933006563	hypothetical protein; Provisional; Region: PRK05170
1218933006564	Glycogen synthesis protein; Region: GlgS; cl11663
1218933006565	disulfide bond formation protein B; Provisional; Region: PRK01749
1218933006566	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
1218933006567	fatty acid metabolism regulator; Provisional; Region: PRK04984
1218933006568	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933006569	DNA-binding site [nucleotide binding]; DNA binding site
1218933006570	FadR C-terminal domain; Region: FadR_C; pfam07840
1218933006571	SpoVR family protein; Provisional; Region: PRK11767
1218933006572	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
1218933006573	Class I aldolases; Region: Aldolase_Class_I; cl17187
1218933006574	catalytic residue [active]
1218933006575	AAA domain; Region: AAA_33; pfam13671
1218933006576	AAA domain; Region: AAA_17; pfam13207
1218933006577	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1218933006578	active site
1218933006579	phosphorylation site [posttranslational modification]
1218933006580	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
1218933006581	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1218933006582	active site
1218933006583	P-loop; other site
1218933006584	phosphorylation site [posttranslational modification]
1218933006585	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
1218933006586	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1218933006587	active site
1218933006588	ADP/pyrophosphate binding site [chemical binding]; other site
1218933006589	dimerization interface [polypeptide binding]; other site
1218933006590	allosteric effector site; other site
1218933006591	fructose-1,6-bisphosphate binding site; other site
1218933006592	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1218933006593	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1218933006594	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933006595	putative substrate translocation pore; other site
1218933006596	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
1218933006597	hypothetical protein; Provisional; Region: PRK05325
1218933006598	PrkA family serine protein kinase; Provisional; Region: PRK15455
1218933006599	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933006600	Walker A motif; other site
1218933006601	ATP binding site [chemical binding]; other site
1218933006602	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
1218933006603	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
1218933006604	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1218933006605	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1218933006606	active site
1218933006607	catalytic tetrad [active]
1218933006608	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
1218933006609	active site
1218933006610	phosphate binding residues; other site
1218933006611	catalytic residues [active]
1218933006612	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
1218933006613	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1218933006614	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1218933006615	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1218933006616	SelR domain; Region: SelR; pfam01641
1218933006617	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139
1218933006618	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
1218933006619	Isochorismatase family; Region: Isochorismatase; pfam00857
1218933006620	catalytic triad [active]
1218933006621	metal binding site [ion binding]; metal-binding site
1218933006622	conserved cis-peptide bond; other site
1218933006623	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
1218933006624	active site
1218933006625	homodimer interface [polypeptide binding]; other site
1218933006626	protease 4; Provisional; Region: PRK10949
1218933006627	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
1218933006628	tandem repeat interface [polypeptide binding]; other site
1218933006629	oligomer interface [polypeptide binding]; other site
1218933006630	active site residues [active]
1218933006631	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019
1218933006632	tandem repeat interface [polypeptide binding]; other site
1218933006633	oligomer interface [polypeptide binding]; other site
1218933006634	active site residues [active]
1218933006635	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1218933006636	putative FMN binding site [chemical binding]; other site
1218933006637	DNA topoisomerase III; Provisional; Region: PRK07726
1218933006638	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1218933006639	active site
1218933006640	putative interdomain interaction site [polypeptide binding]; other site
1218933006641	putative metal-binding site [ion binding]; other site
1218933006642	putative nucleotide binding site [chemical binding]; other site
1218933006643	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1218933006644	domain I; other site
1218933006645	DNA binding groove [nucleotide binding]
1218933006646	phosphate binding site [ion binding]; other site
1218933006647	domain II; other site
1218933006648	domain III; other site
1218933006649	nucleotide binding site [chemical binding]; other site
1218933006650	catalytic site [active]
1218933006651	domain IV; other site
1218933006652	Protein of unknown function (DUF1496); Region: DUF1496; pfam07383
1218933006653	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1218933006654	putative catalytic site [active]
1218933006655	putative phosphate binding site [ion binding]; other site
1218933006656	active site
1218933006657	metal binding site A [ion binding]; metal-binding site
1218933006658	DNA binding site [nucleotide binding]
1218933006659	putative AP binding site [nucleotide binding]; other site
1218933006660	putative metal binding site B [ion binding]; other site
1218933006661	Predicted membrane protein [Function unknown]; Region: COG2860
1218933006662	UPF0126 domain; Region: UPF0126; pfam03458
1218933006663	UPF0126 domain; Region: UPF0126; pfam03458
1218933006664	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1218933006665	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1218933006666	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1218933006667	putative active site [active]
1218933006668	putative substrate binding site [chemical binding]; other site
1218933006669	putative cosubstrate binding site; other site
1218933006670	catalytic site [active]
1218933006671	hypothetical protein; Provisional; Region: PRK10279
1218933006672	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
1218933006673	active site
1218933006674	nucleophile elbow; other site
1218933006675	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933006676	active site
1218933006677	response regulator of RpoS; Provisional; Region: PRK10693
1218933006678	phosphorylation site [posttranslational modification]
1218933006679	intermolecular recognition site; other site
1218933006680	dimerization interface [polypeptide binding]; other site
1218933006681	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1218933006682	active site
1218933006683	tetramer interface; other site
1218933006684	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
1218933006685	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1218933006686	thymidine kinase; Provisional; Region: PRK04296
1218933006687	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1218933006688	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1218933006689	putative catalytic cysteine [active]
1218933006690	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1218933006691	putative active site [active]
1218933006692	metal binding site [ion binding]; metal-binding site
1218933006693	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
1218933006694	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1218933006695	peptide binding site [polypeptide binding]; other site
1218933006696	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
1218933006697	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1218933006698	peptide binding site [polypeptide binding]; other site
1218933006699	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
1218933006700	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933006701	dimer interface [polypeptide binding]; other site
1218933006702	conserved gate region; other site
1218933006703	putative PBP binding loops; other site
1218933006704	ABC-ATPase subunit interface; other site
1218933006705	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
1218933006706	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1218933006707	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933006708	dimer interface [polypeptide binding]; other site
1218933006709	conserved gate region; other site
1218933006710	ABC-ATPase subunit interface; other site
1218933006711	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
1218933006712	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933006713	Walker A/P-loop; other site
1218933006714	ATP binding site [chemical binding]; other site
1218933006715	Q-loop/lid; other site
1218933006716	ABC transporter signature motif; other site
1218933006717	Walker B; other site
1218933006718	D-loop; other site
1218933006719	H-loop/switch region; other site
1218933006720	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1218933006721	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
1218933006722	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933006723	Walker A/P-loop; other site
1218933006724	ATP binding site [chemical binding]; other site
1218933006725	Q-loop/lid; other site
1218933006726	ABC transporter signature motif; other site
1218933006727	Walker B; other site
1218933006728	D-loop; other site
1218933006729	H-loop/switch region; other site
1218933006730	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1218933006731	dsDNA-mimic protein; Reviewed; Region: PRK05094
1218933006732	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1218933006733	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1218933006734	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
1218933006735	putative active site [active]
1218933006736	catalytic site [active]
1218933006737	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
1218933006738	putative active site [active]
1218933006739	catalytic site [active]
1218933006740	methyl-accepting protein IV; Provisional; Region: PRK09793
1218933006741	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
1218933006742	dimer interface [polypeptide binding]; other site
1218933006743	ligand binding site [chemical binding]; other site
1218933006744	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933006745	dimer interface [polypeptide binding]; other site
1218933006746	putative CheW interface [polypeptide binding]; other site
1218933006747	YciI-like protein; Reviewed; Region: PRK11370
1218933006748	transport protein TonB; Provisional; Region: PRK10819
1218933006749	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1218933006750	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1218933006751	intracellular septation protein A; Reviewed; Region: PRK00259
1218933006752	hypothetical protein; Provisional; Region: PRK02868
1218933006753	outer membrane protein W; Provisional; Region: PRK10959
1218933006754	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629
1218933006755	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1218933006756	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1218933006757	substrate binding site [chemical binding]; other site
1218933006758	active site
1218933006759	catalytic residues [active]
1218933006760	heterodimer interface [polypeptide binding]; other site
1218933006761	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1218933006762	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1218933006763	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933006764	catalytic residue [active]
1218933006765	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
1218933006766	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1218933006767	active site
1218933006768	ribulose/triose binding site [chemical binding]; other site
1218933006769	phosphate binding site [ion binding]; other site
1218933006770	substrate (anthranilate) binding pocket [chemical binding]; other site
1218933006771	product (indole) binding pocket [chemical binding]; other site
1218933006772	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1218933006773	active site
1218933006774	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1218933006775	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1218933006776	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1218933006777	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1218933006778	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1218933006779	glutamine binding [chemical binding]; other site
1218933006780	catalytic triad [active]
1218933006781	anthranilate synthase component I; Provisional; Region: PRK13564
1218933006782	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1218933006783	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1218933006784	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
1218933006785	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1218933006786	active site
1218933006787	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1218933006788	hypothetical protein; Provisional; Region: PRK11630
1218933006789	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
1218933006790	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1218933006791	RNA binding surface [nucleotide binding]; other site
1218933006792	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
1218933006793	probable active site [active]
1218933006794	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1218933006795	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
1218933006796	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
1218933006797	homodimer interface [polypeptide binding]; other site
1218933006798	Walker A motif; other site
1218933006799	ATP binding site [chemical binding]; other site
1218933006800	hydroxycobalamin binding site [chemical binding]; other site
1218933006801	Walker B motif; other site
1218933006802	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
1218933006803	Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340
1218933006804	NADP binding site [chemical binding]; other site
1218933006805	homodimer interface [polypeptide binding]; other site
1218933006806	active site
1218933006807	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
1218933006808	putative inner membrane peptidase; Provisional; Region: PRK11778
1218933006809	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1218933006810	tandem repeat interface [polypeptide binding]; other site
1218933006811	oligomer interface [polypeptide binding]; other site
1218933006812	active site residues [active]
1218933006813	hypothetical protein; Provisional; Region: PRK11037
1218933006814	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1218933006815	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1218933006816	active site
1218933006817	interdomain interaction site; other site
1218933006818	putative metal-binding site [ion binding]; other site
1218933006819	nucleotide binding site [chemical binding]; other site
1218933006820	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1218933006821	domain I; other site
1218933006822	DNA binding groove [nucleotide binding]
1218933006823	phosphate binding site [ion binding]; other site
1218933006824	domain II; other site
1218933006825	domain III; other site
1218933006826	nucleotide binding site [chemical binding]; other site
1218933006827	catalytic site [active]
1218933006828	domain IV; other site
1218933006829	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1218933006830	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1218933006831	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
1218933006832	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
1218933006833	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
1218933006834	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933006835	The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443
1218933006836	substrate binding site [chemical binding]; other site
1218933006837	putative dimerization interface [polypeptide binding]; other site
1218933006838	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
1218933006839	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933006840	putative substrate translocation pore; other site
1218933006841	POT family; Region: PTR2; pfam00854
1218933006842	endonuclease III; Provisional; Region: PRK10702
1218933006843	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1218933006844	minor groove reading motif; other site
1218933006845	helix-hairpin-helix signature motif; other site
1218933006846	substrate binding pocket [chemical binding]; other site
1218933006847	active site
1218933006848	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1218933006849	electron transport complex RsxE subunit; Provisional; Region: PRK12405
1218933006850	electron transport complex protein RnfG; Validated; Region: PRK01908
1218933006851	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
1218933006852	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
1218933006853	SLBB domain; Region: SLBB; pfam10531
1218933006854	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1218933006855	electron transport complex protein RnfB; Provisional; Region: PRK05113
1218933006856	Putative Fe-S cluster; Region: FeS; pfam04060
1218933006857	4Fe-4S binding domain; Region: Fer4; pfam00037
1218933006858	electron transport complex protein RsxA; Provisional; Region: PRK05151
1218933006859	oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391
1218933006860	L-arabinose isomerase; Provisional; Region: PRK02929
1218933006861	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
1218933006862	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
1218933006863	trimer interface [polypeptide binding]; other site
1218933006864	putative substrate binding site [chemical binding]; other site
1218933006865	putative metal binding site [ion binding]; other site
1218933006866	ribulokinase; Provisional; Region: PRK04123
1218933006867	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
1218933006868	N- and C-terminal domain interface [polypeptide binding]; other site
1218933006869	active site
1218933006870	MgATP binding site [chemical binding]; other site
1218933006871	catalytic site [active]
1218933006872	metal binding site [ion binding]; metal-binding site
1218933006873	carbohydrate binding site [chemical binding]; other site
1218933006874	homodimer interface [polypeptide binding]; other site
1218933006875	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
1218933006876	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
1218933006877	ligand binding site [chemical binding]; other site
1218933006878	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
1218933006879	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1218933006880	Walker A/P-loop; other site
1218933006881	ATP binding site [chemical binding]; other site
1218933006882	Q-loop/lid; other site
1218933006883	ABC transporter signature motif; other site
1218933006884	Walker B; other site
1218933006885	D-loop; other site
1218933006886	H-loop/switch region; other site
1218933006887	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1218933006888	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1218933006889	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1218933006890	TM-ABC transporter signature motif; other site
1218933006891	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
1218933006892	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1218933006893	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933006894	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933006895	putative oxidoreductase; Provisional; Region: PRK11579
1218933006896	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1218933006897	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1218933006898	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1218933006899	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
1218933006900	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
1218933006901	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1218933006902	adenosine deaminase; Provisional; Region: PRK09358
1218933006903	active site
1218933006904	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1218933006905	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
1218933006906	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
1218933006907	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
1218933006908	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1218933006909	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1218933006910	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1218933006911	Class II fumarases; Region: Fumarase_classII; cd01362
1218933006912	active site
1218933006913	tetramer interface [polypeptide binding]; other site
1218933006914	DNA replication terminus site-binding protein; Provisional; Region: PRK02951
1218933006915	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1218933006916	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933006917	putative substrate translocation pore; other site
1218933006918	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933006919	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933006920	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1218933006921	dimerization interface [polypeptide binding]; other site
1218933006922	substrate binding pocket [chemical binding]; other site
1218933006923	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1218933006924	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1218933006925	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1218933006926	putative dithiobiotin synthetase; Provisional; Region: PRK12374
1218933006927	AAA domain; Region: AAA_26; pfam13500
1218933006928	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933006929	putative substrate translocation pore; other site
1218933006930	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1218933006931	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933006932	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
1218933006933	hypothetical protein; Provisional; Region: PRK13659
1218933006934	malonic semialdehyde reductase; Provisional; Region: PRK10538
1218933006935	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
1218933006936	putative NAD(P) binding site [chemical binding]; other site
1218933006937	homodimer interface [polypeptide binding]; other site
1218933006938	homotetramer interface [polypeptide binding]; other site
1218933006939	active site
1218933006940	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1218933006941	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1218933006942	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933006943	homodimer interface [polypeptide binding]; other site
1218933006944	catalytic residue [active]
1218933006945	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
1218933006946	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669
1218933006947	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1218933006948	active site
1218933006949	motif I; other site
1218933006950	motif II; other site
1218933006951	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1218933006952	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1218933006953	conserved cys residue [active]
1218933006954	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933006955	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1218933006956	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1218933006957	4-oxalocrotonate tautomerase; Provisional; Region: PRK01271
1218933006958	aromatic amino acid exporter; Provisional; Region: PRK11689
1218933006959	EamA-like transporter family; Region: EamA; cl17759
1218933006960	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1218933006961	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1218933006962	catalytic residue [active]
1218933006963	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931
1218933006964	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1218933006965	inhibitor-cofactor binding pocket; inhibition site
1218933006966	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933006967	catalytic residue [active]
1218933006968	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
1218933006969	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
1218933006970	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
1218933006971	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
1218933006972	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933006973	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1218933006974	substrate binding pocket [chemical binding]; other site
1218933006975	dimerization interface [polypeptide binding]; other site
1218933006976	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1218933006977	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1218933006978	hypothetical protein; Provisional; Region: PRK10515
1218933006979	chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348
1218933006980	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933006981	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1218933006982	dimerization interface [polypeptide binding]; other site
1218933006983	Cache domain; Region: Cache_1; pfam02743
1218933006984	HAMP domain; Region: HAMP; pfam00672
1218933006985	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1218933006986	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933006987	dimer interface [polypeptide binding]; other site
1218933006988	putative CheW interface [polypeptide binding]; other site
1218933006989	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1218933006990	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933006991	Coenzyme A binding pocket [chemical binding]; other site
1218933006992	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933006993	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1218933006994	putative substrate translocation pore; other site
1218933006995	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
1218933006996	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1218933006997	Cytochrome b562; Region: Cytochrom_B562; pfam07361
1218933006998	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
1218933006999	Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305
1218933007000	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1218933007001	Virulence factor SrfB; Region: SrfB; pfam07520
1218933007002	Putative bacterial virulence factor; Region: Virul_Fac; pfam10139
1218933007003	SnoaL-like domain; Region: SnoaL_2; pfam12680
1218933007004	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
1218933007005	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1218933007006	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933007007	S-adenosylmethionine binding site [chemical binding]; other site
1218933007008	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
1218933007009	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1218933007010	E-class dimer interface [polypeptide binding]; other site
1218933007011	P-class dimer interface [polypeptide binding]; other site
1218933007012	active site
1218933007013	Cu2+ binding site [ion binding]; other site
1218933007014	Zn2+ binding site [ion binding]; other site
1218933007015	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1218933007016	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1218933007017	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1218933007018	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1218933007019	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1218933007020	O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286
1218933007021	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1218933007022	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1218933007023	DNA binding site [nucleotide binding]
1218933007024	active site
1218933007025	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
1218933007026	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1218933007027	ligand binding site [chemical binding]; other site
1218933007028	flexible hinge region; other site
1218933007029	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1218933007030	putative switch regulator; other site
1218933007031	non-specific DNA interactions [nucleotide binding]; other site
1218933007032	DNA binding site [nucleotide binding]
1218933007033	sequence specific DNA binding site [nucleotide binding]; other site
1218933007034	putative cAMP binding site [chemical binding]; other site
1218933007035	universal stress protein UspE; Provisional; Region: PRK11175
1218933007036	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1218933007037	Ligand Binding Site [chemical binding]; other site
1218933007038	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1218933007039	Ligand Binding Site [chemical binding]; other site
1218933007040	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
1218933007041	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1218933007042	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1218933007043	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
1218933007044	ligand binding site [chemical binding]; other site
1218933007045	homodimer interface [polypeptide binding]; other site
1218933007046	NAD(P) binding site [chemical binding]; other site
1218933007047	trimer interface B [polypeptide binding]; other site
1218933007048	trimer interface A [polypeptide binding]; other site
1218933007049	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1218933007050	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1218933007051	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1218933007052	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
1218933007053	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
1218933007054	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1218933007055	hypothetical protein; Provisional; Region: PRK10941
1218933007056	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
1218933007057	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1218933007058	binding surface
1218933007059	TPR motif; other site
1218933007060	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
1218933007061	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1218933007062	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933007063	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1218933007064	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1218933007065	RF-1 domain; Region: RF-1; pfam00472
1218933007066	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1218933007067	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1218933007068	tRNA; other site
1218933007069	putative tRNA binding site [nucleotide binding]; other site
1218933007070	putative NADP binding site [chemical binding]; other site
1218933007071	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1218933007072	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
1218933007073	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
1218933007074	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
1218933007075	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1218933007076	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1218933007077	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1218933007078	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1218933007079	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1218933007080	active site
1218933007081	hypothetical protein; Provisional; Region: PRK10692
1218933007082	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1218933007083	putative active site [active]
1218933007084	catalytic residue [active]
1218933007085	GTP-binding protein YchF; Reviewed; Region: PRK09601
1218933007086	YchF GTPase; Region: YchF; cd01900
1218933007087	G1 box; other site
1218933007088	GTP/Mg2+ binding site [chemical binding]; other site
1218933007089	Switch I region; other site
1218933007090	G2 box; other site
1218933007091	Switch II region; other site
1218933007092	G3 box; other site
1218933007093	G4 box; other site
1218933007094	G5 box; other site
1218933007095	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1218933007096	integrase; Provisional; Region: PRK09692
1218933007097	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1218933007098	active site
1218933007099	Int/Topo IB signature motif; other site
1218933007100	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1218933007101	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1218933007102	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
1218933007103	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
1218933007104	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1218933007105	cofactor binding site; other site
1218933007106	DNA binding site [nucleotide binding]
1218933007107	substrate interaction site [chemical binding]; other site
1218933007108	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1218933007109	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1218933007110	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
1218933007111	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1218933007112	active site
1218933007113	catalytic residues [active]
1218933007114	DNA binding site [nucleotide binding]
1218933007115	Int/Topo IB signature motif; other site
1218933007116	hypothetical protein; Reviewed; Region: PRK00024
1218933007117	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1218933007118	MPN+ (JAMM) motif; other site
1218933007119	Zinc-binding site [ion binding]; other site
1218933007120	Protein of unknown function (DUF2787); Region: DUF2787; pfam10980
1218933007121	Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423
1218933007122	Phage minor structural protein GP20; Region: Phage_GP20; pfam06810
1218933007123	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
1218933007124	Predicted transcriptional regulator [Transcription]; Region: COG2378
1218933007125	HTH domain; Region: HTH_11; pfam08279
1218933007126	WYL domain; Region: WYL; pfam13280
1218933007127	Ycf46; Provisional; Region: ycf46; CHL00195
1218933007128	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933007129	Walker A motif; other site
1218933007130	ATP binding site [chemical binding]; other site
1218933007131	Walker B motif; other site
1218933007132	arginine finger; other site
1218933007133	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933007134	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1218933007135	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
1218933007136	transmembrane helices; other site
1218933007137	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1218933007138	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933007139	putative substrate translocation pore; other site
1218933007140	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1218933007141	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933007142	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933007143	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
1218933007144	putative effector binding pocket; other site
1218933007145	putative dimerization interface [polypeptide binding]; other site
1218933007146	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933007147	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1218933007148	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1218933007149	dimerization interface [polypeptide binding]; other site
1218933007150	substrate binding pocket [chemical binding]; other site
1218933007151	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933007152	D-galactonate transporter; Region: 2A0114; TIGR00893
1218933007153	putative substrate translocation pore; other site
1218933007154	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933007155	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1218933007156	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1218933007157	NAD(P) binding site [chemical binding]; other site
1218933007158	active site
1218933007159	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1218933007160	TPP-binding site [chemical binding]; other site
1218933007161	dimer interface [polypeptide binding]; other site
1218933007162	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1218933007163	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1218933007164	PYR/PP interface [polypeptide binding]; other site
1218933007165	dimer interface [polypeptide binding]; other site
1218933007166	TPP binding site [chemical binding]; other site
1218933007167	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1218933007168	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1218933007169	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1218933007170	RNA ligase; Region: RNA_ligase; pfam09414
1218933007171	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1218933007172	Zn2+ binding site [ion binding]; other site
1218933007173	Mg2+ binding site [ion binding]; other site
1218933007174	AAA domain; Region: AAA_33; pfam13671
1218933007175	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1218933007176	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1218933007177	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1218933007178	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1218933007179	ABC-ATPase subunit  interface; other site
1218933007180	dimer interface [polypeptide binding]; other site
1218933007181	putative PBP binding regions; other site
1218933007182	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1218933007183	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1218933007184	metal binding site [ion binding]; metal-binding site
1218933007185	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1218933007186	active site
1218933007187	catalytic triad [active]
1218933007188	Protein of unknown function DUF262; Region: DUF262; pfam03235
1218933007189	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1218933007190	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1218933007191	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1218933007192	YodA lipocalin-like domain; Region: YodA; cl01365
1218933007193	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1218933007194	active site
1218933007195	metal binding site [ion binding]; metal-binding site
1218933007196	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1218933007197	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1218933007198	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
1218933007199	active site
1218933007200	cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852
1218933007201	beta-galactosidase; Region: BGL; TIGR03356
1218933007202	PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796
1218933007203	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1218933007204	active site turn [active]
1218933007205	phosphorylation site [posttranslational modification]
1218933007206	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
1218933007207	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1218933007208	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1218933007209	DNA binding site [nucleotide binding]
1218933007210	domain linker motif; other site
1218933007211	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
1218933007212	dimerization interface (closed form) [polypeptide binding]; other site
1218933007213	ligand binding site [chemical binding]; other site
1218933007214	alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199
1218933007215	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
1218933007216	metal binding site [ion binding]; metal-binding site
1218933007217	Autotransporter beta-domain; Region: Autotransporter; cl17461
1218933007218	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
1218933007219	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1218933007220	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1218933007221	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1218933007222	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
1218933007223	metal binding site [ion binding]; metal-binding site
1218933007224	dimer interface [polypeptide binding]; other site
1218933007225	Flavin Reductases; Region: FlaRed; cl00801
1218933007226	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1218933007227	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1218933007228	active site
1218933007229	non-prolyl cis peptide bond; other site
1218933007230	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1218933007231	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1218933007232	substrate binding pocket [chemical binding]; other site
1218933007233	membrane-bound complex binding site; other site
1218933007234	hinge residues; other site
1218933007235	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1218933007236	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1218933007237	substrate binding pocket [chemical binding]; other site
1218933007238	membrane-bound complex binding site; other site
1218933007239	hinge residues; other site
1218933007240	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933007241	Coenzyme A binding pocket [chemical binding]; other site
1218933007242	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933007243	dimer interface [polypeptide binding]; other site
1218933007244	conserved gate region; other site
1218933007245	putative PBP binding loops; other site
1218933007246	ABC-ATPase subunit interface; other site
1218933007247	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1218933007248	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1218933007249	Walker A/P-loop; other site
1218933007250	ATP binding site [chemical binding]; other site
1218933007251	Q-loop/lid; other site
1218933007252	ABC transporter signature motif; other site
1218933007253	Walker B; other site
1218933007254	D-loop; other site
1218933007255	H-loop/switch region; other site
1218933007256	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1218933007257	ArsC family; Region: ArsC; pfam03960
1218933007258	catalytic residues [active]
1218933007259	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1218933007260	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
1218933007261	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
1218933007262	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
1218933007263	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1218933007264	Walker A/P-loop; other site
1218933007265	ATP binding site [chemical binding]; other site
1218933007266	Q-loop/lid; other site
1218933007267	ABC transporter signature motif; other site
1218933007268	Walker B; other site
1218933007269	D-loop; other site
1218933007270	H-loop/switch region; other site
1218933007271	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
1218933007272	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1218933007273	Walker A/P-loop; other site
1218933007274	ATP binding site [chemical binding]; other site
1218933007275	Q-loop/lid; other site
1218933007276	ABC transporter signature motif; other site
1218933007277	Walker B; other site
1218933007278	D-loop; other site
1218933007279	H-loop/switch region; other site
1218933007280	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1218933007281	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1218933007282	TM-ABC transporter signature motif; other site
1218933007283	HEAT repeats; Region: HEAT_2; pfam13646
1218933007284	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1218933007285	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1218933007286	TM-ABC transporter signature motif; other site
1218933007287	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1218933007288	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
1218933007289	putative ligand binding site [chemical binding]; other site
1218933007290	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1218933007291	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933007292	DNA-binding site [nucleotide binding]; DNA binding site
1218933007293	FCD domain; Region: FCD; pfam07729
1218933007294	urea carboxylase; Region: urea_carbox; TIGR02712
1218933007295	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1218933007296	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1218933007297	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1218933007298	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
1218933007299	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1218933007300	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1218933007301	carboxyltransferase (CT) interaction site; other site
1218933007302	biotinylation site [posttranslational modification]; other site
1218933007303	allophanate hydrolase; Provisional; Region: PRK08186
1218933007304	Amidase; Region: Amidase; cl11426
1218933007305	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1218933007306	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1218933007307	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1218933007308	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629
1218933007309	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629
1218933007310	Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917
1218933007311	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
1218933007312	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1218933007313	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1218933007314	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
1218933007315	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1218933007316	active site
1218933007317	catalytic triad [active]
1218933007318	dimer interface [polypeptide binding]; other site
1218933007319	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1218933007320	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1218933007321	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1218933007322	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1218933007323	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1218933007324	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1218933007325	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1218933007326	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
1218933007327	colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414
1218933007328	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933007329	DNA-binding site [nucleotide binding]; DNA binding site
1218933007330	FCD domain; Region: FCD; pfam07729
1218933007331	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
1218933007332	Pathogenicity factor; Region: AvrE; pfam11725
1218933007333	Pectate lyase; Region: Pectate_lyase; pfam03211
1218933007334	HrpZ; Region: Hairpins; pfam04877
1218933007335	type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516
1218933007336	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1218933007337	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1218933007338	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1218933007339	HrpF protein; Region: HrpF; pfam06266
1218933007340	HrpE/YscL/FliH and V-type ATPase subunit E; Region: HrpE; pfam06188
1218933007341	type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544
1218933007342	Type III secretion needle MxiH like; Region: MxiH; pfam09392
1218933007343	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1218933007344	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1218933007345	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933007346	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1218933007347	Walker A motif; other site
1218933007348	ATP binding site [chemical binding]; other site
1218933007349	Walker B motif; other site
1218933007350	arginine finger; other site
1218933007351	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
1218933007352	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1218933007353	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933007354	active site
1218933007355	phosphorylation site [posttranslational modification]
1218933007356	intermolecular recognition site; other site
1218933007357	dimerization interface [polypeptide binding]; other site
1218933007358	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1218933007359	DNA binding residues [nucleotide binding]
1218933007360	dimerization interface [polypeptide binding]; other site
1218933007361	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1218933007362	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1218933007363	putative active site [active]
1218933007364	heme pocket [chemical binding]; other site
1218933007365	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1218933007366	putative active site [active]
1218933007367	heme pocket [chemical binding]; other site
1218933007368	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1218933007369	Histidine kinase; Region: HisKA_3; pfam07730
1218933007370	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933007371	ATP binding site [chemical binding]; other site
1218933007372	Mg2+ binding site [ion binding]; other site
1218933007373	G-X-G motif; other site
1218933007374	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1218933007375	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1218933007376	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1218933007377	DNA binding residues [nucleotide binding]
1218933007378	type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568
1218933007379	TyeA; Region: TyeA; cl07611
1218933007380	type III secretion protein, HrcV family; Region: hrcV; TIGR01399
1218933007381	FHIPEP family; Region: FHIPEP; pfam00771
1218933007382	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
1218933007383	type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546
1218933007384	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1218933007385	Walker A motif; other site
1218933007386	ATP binding site [chemical binding]; other site
1218933007387	Walker B motif; other site
1218933007388	type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551
1218933007389	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1218933007390	type III secretion system protein YscR; Provisional; Region: PRK12797
1218933007391	type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403
1218933007392	Bacterial export proteins, family 1; Region: Bac_export_1; pfam01311
1218933007393	type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404
1218933007394	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
1218933007395	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933007396	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933007397	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1218933007398	dimerization interface [polypeptide binding]; other site
1218933007399	hypothetical protein; Provisional; Region: PRK07079
1218933007400	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679
1218933007401	metal binding site [ion binding]; metal-binding site
1218933007402	putative dimer interface [polypeptide binding]; other site
1218933007403	Bor protein; Region: Lambda_Bor; pfam06291
1218933007404	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1218933007405	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1218933007406	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
1218933007407	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
1218933007408	active site
1218933007409	octamer interface [polypeptide binding]; other site
1218933007410	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933007411	dimer interface [polypeptide binding]; other site
1218933007412	conserved gate region; other site
1218933007413	ABC-ATPase subunit interface; other site
1218933007414	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1218933007415	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1218933007416	Walker A/P-loop; other site
1218933007417	ATP binding site [chemical binding]; other site
1218933007418	Q-loop/lid; other site
1218933007419	ABC transporter signature motif; other site
1218933007420	Walker B; other site
1218933007421	D-loop; other site
1218933007422	H-loop/switch region; other site
1218933007423	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1218933007424	NIL domain; Region: NIL; pfam09383
1218933007425	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
1218933007426	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1218933007427	active site
1218933007428	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
1218933007429	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1218933007430	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933007431	dimerization interface [polypeptide binding]; other site
1218933007432	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933007433	dimer interface [polypeptide binding]; other site
1218933007434	putative CheW interface [polypeptide binding]; other site
1218933007435	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
1218933007436	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1218933007437	inhibitor-cofactor binding pocket; inhibition site
1218933007438	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933007439	catalytic residue [active]
1218933007440	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1218933007441	active site
1218933007442	ATP binding site [chemical binding]; other site
1218933007443	substrate binding site [chemical binding]; other site
1218933007444	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1218933007445	classical (c) SDRs; Region: SDR_c; cd05233
1218933007446	NAD(P) binding site [chemical binding]; other site
1218933007447	active site
1218933007448	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1218933007449	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933007450	dimer interface [polypeptide binding]; other site
1218933007451	conserved gate region; other site
1218933007452	putative PBP binding loops; other site
1218933007453	ABC-ATPase subunit interface; other site
1218933007454	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933007455	dimer interface [polypeptide binding]; other site
1218933007456	conserved gate region; other site
1218933007457	putative PBP binding loops; other site
1218933007458	ABC-ATPase subunit interface; other site
1218933007459	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1218933007460	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1218933007461	succinic semialdehyde dehydrogenase; Region: PLN02278
1218933007462	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1218933007463	tetramerization interface [polypeptide binding]; other site
1218933007464	NAD(P) binding site [chemical binding]; other site
1218933007465	catalytic residues [active]
1218933007466	4-aminobutyrate aminotransferase; Provisional; Region: PRK06777
1218933007467	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1218933007468	inhibitor-cofactor binding pocket; inhibition site
1218933007469	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933007470	catalytic residue [active]
1218933007471	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1218933007472	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933007473	DNA-binding site [nucleotide binding]; DNA binding site
1218933007474	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1218933007475	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933007476	homodimer interface [polypeptide binding]; other site
1218933007477	catalytic residue [active]
1218933007478	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1218933007479	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1218933007480	Walker A/P-loop; other site
1218933007481	ATP binding site [chemical binding]; other site
1218933007482	Q-loop/lid; other site
1218933007483	ABC transporter signature motif; other site
1218933007484	Walker B; other site
1218933007485	D-loop; other site
1218933007486	H-loop/switch region; other site
1218933007487	TOBE domain; Region: TOBE_2; pfam08402
1218933007488	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
1218933007489	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1218933007490	NAD(P) binding site [chemical binding]; other site
1218933007491	active site
1218933007492	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
1218933007493	active site
1218933007494	iron coordination sites [ion binding]; other site
1218933007495	substrate binding pocket [chemical binding]; other site
1218933007496	Stf0 sulphotransferase; Region: Sulphotransf; cl01835
1218933007497	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1218933007498	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
1218933007499	inhibitor-cofactor binding pocket; inhibition site
1218933007500	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933007501	catalytic residue [active]
1218933007502	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
1218933007503	AAA domain; Region: AAA_17; pfam13207
1218933007504	AAA domain; Region: AAA_18; pfam13238
1218933007505	hypothetical protein; Provisional; Region: PRK10457
1218933007506	O-methyltransferase; Region: Methyltransf_2; pfam00891
1218933007507	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
1218933007508	YheO-like PAS domain; Region: PAS_6; pfam08348
1218933007509	HTH domain; Region: HTH_22; pfam13309
1218933007510	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1218933007511	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1218933007512	tetramer interface [polypeptide binding]; other site
1218933007513	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933007514	catalytic residue [active]
1218933007515	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1218933007516	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
1218933007517	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812
1218933007518	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1218933007519	dimer interface [polypeptide binding]; other site
1218933007520	active site
1218933007521	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1218933007522	substrate binding site [chemical binding]; other site
1218933007523	catalytic residue [active]
1218933007524	OsmC-like protein; Region: OsmC; cl00767
1218933007525	MarR family; Region: MarR_2; cl17246
1218933007526	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1218933007527	EamA-like transporter family; Region: EamA; pfam00892
1218933007528	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1218933007529	EamA-like transporter family; Region: EamA; pfam00892
1218933007530	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
1218933007531	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
1218933007532	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1218933007533	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1218933007534	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1218933007535	[4Fe-4S] binding site [ion binding]; other site
1218933007536	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1218933007537	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1218933007538	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1218933007539	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1218933007540	molybdopterin cofactor binding site; other site
1218933007541	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
1218933007542	nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600
1218933007543	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
1218933007544	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933007545	dimerization interface [polypeptide binding]; other site
1218933007546	Histidine kinase; Region: HisKA_3; pfam07730
1218933007547	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933007548	ATP binding site [chemical binding]; other site
1218933007549	Mg2+ binding site [ion binding]; other site
1218933007550	G-X-G motif; other site
1218933007551	transcriptional regulator NarL; Provisional; Region: PRK10651
1218933007552	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933007553	active site
1218933007554	phosphorylation site [posttranslational modification]
1218933007555	intermolecular recognition site; other site
1218933007556	dimerization interface [polypeptide binding]; other site
1218933007557	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1218933007558	DNA binding residues [nucleotide binding]
1218933007559	dimerization interface [polypeptide binding]; other site
1218933007560	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1218933007561	Protein of unknown function, DUF481; Region: DUF481; pfam04338
1218933007562	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
1218933007563	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1218933007564	putative active site pocket [active]
1218933007565	dimerization interface [polypeptide binding]; other site
1218933007566	putative catalytic residue [active]
1218933007567	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1218933007568	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1218933007569	FAD binding pocket [chemical binding]; other site
1218933007570	FAD binding motif [chemical binding]; other site
1218933007571	phosphate binding motif [ion binding]; other site
1218933007572	NAD binding pocket [chemical binding]; other site
1218933007573	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
1218933007574	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1218933007575	putative transporter; Provisional; Region: PRK11660
1218933007576	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1218933007577	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1218933007578	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1218933007579	dihydromonapterin reductase; Provisional; Region: PRK06483
1218933007580	pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357
1218933007581	NADP binding site [chemical binding]; other site
1218933007582	substrate binding pocket [chemical binding]; other site
1218933007583	active site
1218933007584	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1218933007585	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1218933007586	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1218933007587	DNA binding residues [nucleotide binding]
1218933007588	YceI-like domain; Region: YceI; cl01001
1218933007589	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1218933007590	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1218933007591	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
1218933007592	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933007593	active site
1218933007594	phosphorylation site [posttranslational modification]
1218933007595	intermolecular recognition site; other site
1218933007596	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1218933007597	DNA binding site [nucleotide binding]
1218933007598	sensor protein RstB; Provisional; Region: PRK10604
1218933007599	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933007600	dimerization interface [polypeptide binding]; other site
1218933007601	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1218933007602	dimer interface [polypeptide binding]; other site
1218933007603	phosphorylation site [posttranslational modification]
1218933007604	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933007605	ATP binding site [chemical binding]; other site
1218933007606	Mg2+ binding site [ion binding]; other site
1218933007607	G-X-G motif; other site
1218933007608	acid shock protein precursor; Provisional; Region: PRK03577
1218933007609	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1218933007610	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1218933007611	GAF domain; Region: GAF; pfam01590
1218933007612	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1218933007613	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1218933007614	metal binding site [ion binding]; metal-binding site
1218933007615	I-site; other site
1218933007616	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1218933007617	EcsC protein family; Region: EcsC; pfam12787
1218933007618	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
1218933007619	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1218933007620	ATP binding site [chemical binding]; other site
1218933007621	putative Mg++ binding site [ion binding]; other site
1218933007622	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1218933007623	nucleotide binding region [chemical binding]; other site
1218933007624	ATP-binding site [chemical binding]; other site
1218933007625	Helicase associated domain (HA2); Region: HA2; pfam04408
1218933007626	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
1218933007627	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
1218933007628	azoreductase; Reviewed; Region: PRK00170
1218933007629	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1218933007630	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
1218933007631	hypothetical protein; Provisional; Region: PRK10695
1218933007632	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1218933007633	PAS domain; Region: PAS_9; pfam13426
1218933007634	putative active site [active]
1218933007635	heme pocket [chemical binding]; other site
1218933007636	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1218933007637	HAMP domain; Region: HAMP; pfam00672
1218933007638	dimerization interface [polypeptide binding]; other site
1218933007639	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933007640	dimer interface [polypeptide binding]; other site
1218933007641	putative CheW interface [polypeptide binding]; other site
1218933007642	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1218933007643	PAS domain; Region: PAS_9; pfam13426
1218933007644	putative active site [active]
1218933007645	heme pocket [chemical binding]; other site
1218933007646	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1218933007647	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1218933007648	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933007649	dimer interface [polypeptide binding]; other site
1218933007650	putative CheW interface [polypeptide binding]; other site
1218933007651	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
1218933007652	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1218933007653	putative ligand binding site [chemical binding]; other site
1218933007654	putative NAD binding site [chemical binding]; other site
1218933007655	catalytic site [active]
1218933007656	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
1218933007657	Domain of unknown function (DUF333); Region: DUF333; pfam03891
1218933007658	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1218933007659	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1218933007660	catalytic loop [active]
1218933007661	iron binding site [ion binding]; other site
1218933007662	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
1218933007663	Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400
1218933007664	Protein of unknown function (DUF4043); Region: DUF4043; pfam13252
1218933007665	Colicin-like bacteriocin tRNase domain; Region: Cloacin; pfam03515
1218933007666	S-type Pyocin; Region: Pyocin_S; pfam06958
1218933007667	large terminase protein; Provisional; Region: 17; PHA02533
1218933007668	large terminase protein; Provisional; Region: 17; PHA02533
1218933007669	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
1218933007670	uncharacterized phage protein; Region: phage_xxxx; TIGR02642
1218933007671	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1218933007672	VRR-NUC domain; Region: VRR_NUC; pfam08774
1218933007673	Protein of unknown function (DUF1367); Region: DUF1367; pfam07105
1218933007674	Putative exonuclease, RdgC; Region: RdgC; cl01122
1218933007675	Helix-turn-helix domain; Region: HTH_36; pfam13730
1218933007676	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1218933007677	non-specific DNA binding site [nucleotide binding]; other site
1218933007678	salt bridge; other site
1218933007679	sequence-specific DNA binding site [nucleotide binding]; other site
1218933007680	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1218933007681	non-specific DNA binding site [nucleotide binding]; other site
1218933007682	Predicted transcriptional regulator [Transcription]; Region: COG2932
1218933007683	salt bridge; other site
1218933007684	sequence-specific DNA binding site [nucleotide binding]; other site
1218933007685	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1218933007686	Catalytic site [active]
1218933007687	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
1218933007688	KTSC domain; Region: KTSC; pfam13619
1218933007689	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1218933007690	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1218933007691	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
1218933007692	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
1218933007693	Ligand Binding Site [chemical binding]; other site
1218933007694	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1218933007695	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
1218933007696	Cl binding site [ion binding]; other site
1218933007697	oligomer interface [polypeptide binding]; other site
1218933007698	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
1218933007699	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1218933007700	peptide binding site [polypeptide binding]; other site
1218933007701	murein peptide amidase A; Provisional; Region: PRK10602
1218933007702	active site
1218933007703	Zn binding site [ion binding]; other site
1218933007704	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1218933007705	dimer interface [polypeptide binding]; other site
1218933007706	catalytic triad [active]
1218933007707	peroxidatic and resolving cysteines [active]
1218933007708	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
1218933007709	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
1218933007710	putative aromatic amino acid binding site; other site
1218933007711	PAS domain; Region: PAS; smart00091
1218933007712	putative active site [active]
1218933007713	heme pocket [chemical binding]; other site
1218933007714	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933007715	Walker A motif; other site
1218933007716	ATP binding site [chemical binding]; other site
1218933007717	Walker B motif; other site
1218933007718	arginine finger; other site
1218933007719	hypothetical protein; Provisional; Region: PRK08201
1218933007720	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_1; cd05678
1218933007721	putative metal binding site [ion binding]; other site
1218933007722	putative dimer interface [polypeptide binding]; other site
1218933007723	hypothetical protein; Provisional; Region: PRK05415
1218933007724	Domain of unknown function (DUF697); Region: DUF697; cl12064
1218933007725	Predicted ATPase [General function prediction only]; Region: COG3106
1218933007726	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1218933007727	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1218933007728	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
1218933007729	RTX toxin acyltransferase family; Region: HlyC; pfam02794
1218933007730	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
1218933007731	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1218933007732	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1218933007733	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1218933007734	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1218933007735	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1218933007736	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1218933007737	DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697
1218933007738	phage shock protein C; Region: phageshock_pspC; TIGR02978
1218933007739	phage shock protein B; Provisional; Region: pspB; PRK09458
1218933007740	phage shock protein PspA; Provisional; Region: PRK10698
1218933007741	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
1218933007742	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933007743	Walker A motif; other site
1218933007744	ATP binding site [chemical binding]; other site
1218933007745	Walker B motif; other site
1218933007746	arginine finger; other site
1218933007747	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1218933007748	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1218933007749	Cellulose binding domain; Region: CBM_3; pfam00942
1218933007750	RES domain; Region: RES; pfam08808
1218933007751	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
1218933007752	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
1218933007753	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1218933007754	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1218933007755	peptide binding site [polypeptide binding]; other site
1218933007756	antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110
1218933007757	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933007758	putative PBP binding loops; other site
1218933007759	dimer interface [polypeptide binding]; other site
1218933007760	ABC-ATPase subunit interface; other site
1218933007761	antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111
1218933007762	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933007763	dimer interface [polypeptide binding]; other site
1218933007764	conserved gate region; other site
1218933007765	putative PBP binding loops; other site
1218933007766	ABC-ATPase subunit interface; other site
1218933007767	antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093
1218933007768	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933007769	Walker A/P-loop; other site
1218933007770	ATP binding site [chemical binding]; other site
1218933007771	Q-loop/lid; other site
1218933007772	ABC transporter signature motif; other site
1218933007773	Walker B; other site
1218933007774	D-loop; other site
1218933007775	H-loop/switch region; other site
1218933007776	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1218933007777	antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112
1218933007778	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933007779	Walker A/P-loop; other site
1218933007780	ATP binding site [chemical binding]; other site
1218933007781	Q-loop/lid; other site
1218933007782	ABC transporter signature motif; other site
1218933007783	Walker B; other site
1218933007784	D-loop; other site
1218933007785	H-loop/switch region; other site
1218933007786	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1218933007787	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984
1218933007788	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1218933007789	NAD binding site [chemical binding]; other site
1218933007790	homotetramer interface [polypeptide binding]; other site
1218933007791	homodimer interface [polypeptide binding]; other site
1218933007792	substrate binding site [chemical binding]; other site
1218933007793	active site
1218933007794	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1218933007795	ApbE family; Region: ApbE; pfam02424
1218933007796	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1218933007797	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1218933007798	putative active site [active]
1218933007799	putative FMN binding site [chemical binding]; other site
1218933007800	putative substrate binding site [chemical binding]; other site
1218933007801	putative catalytic residue [active]
1218933007802	FMN-binding domain; Region: FMN_bind; cl01081
1218933007803	fumarate reductase flavoprotein subunit; Validated; Region: PRK06481
1218933007804	L-aspartate oxidase; Provisional; Region: PRK06175
1218933007805	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
1218933007806	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
1218933007807	Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599
1218933007808	putative active site [active]
1218933007809	putative catalytic site [active]
1218933007810	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933007811	D-galactonate transporter; Region: 2A0114; TIGR00893
1218933007812	putative substrate translocation pore; other site
1218933007813	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1218933007814	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1218933007815	DNA binding site [nucleotide binding]
1218933007816	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1218933007817	ligand binding site [chemical binding]; other site
1218933007818	dimerization interface [polypeptide binding]; other site
1218933007819	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933007820	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933007821	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1218933007822	dimerization interface [polypeptide binding]; other site
1218933007823	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1218933007824	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1218933007825	putative molybdopterin cofactor binding site [chemical binding]; other site
1218933007826	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1218933007827	putative molybdopterin cofactor binding site; other site
1218933007828	exoribonuclease II; Provisional; Region: PRK05054
1218933007829	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1218933007830	RNB domain; Region: RNB; pfam00773
1218933007831	S1 RNA binding domain; Region: S1; pfam00575
1218933007832	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1218933007833	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1218933007834	active site
1218933007835	catalytic tetrad [active]
1218933007836	carbon starvation protein A; Provisional; Region: PRK15015
1218933007837	Carbon starvation protein CstA; Region: CstA; pfam02554
1218933007838	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1218933007839	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
1218933007840	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
1218933007841	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
1218933007842	intersubunit interface [polypeptide binding]; other site
1218933007843	active site
1218933007844	Zn2+ binding site [ion binding]; other site
1218933007845	lipoprotein; Provisional; Region: PRK10540
1218933007846	translation initiation factor Sui1; Validated; Region: PRK06824
1218933007847	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
1218933007848	putative rRNA binding site [nucleotide binding]; other site
1218933007849	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1218933007850	active site
1218933007851	dimer interface [polypeptide binding]; other site
1218933007852	tetratricopeptide repeat protein; Provisional; Region: PRK11788
1218933007853	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1218933007854	TPR motif; other site
1218933007855	binding surface
1218933007856	Predicted membrane protein [Function unknown]; Region: COG3771
1218933007857	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1218933007858	MarR family; Region: MarR_2; pfam12802
1218933007859	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1218933007860	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
1218933007861	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1218933007862	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
1218933007863	bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791
1218933007864	N- and C-terminal domain interface [polypeptide binding]; other site
1218933007865	active site
1218933007866	MgATP binding site [chemical binding]; other site
1218933007867	catalytic site [active]
1218933007868	metal binding site [ion binding]; metal-binding site
1218933007869	putative homotetramer interface [polypeptide binding]; other site
1218933007870	putative homodimer interface [polypeptide binding]; other site
1218933007871	glycerol binding site [chemical binding]; other site
1218933007872	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1218933007873	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1218933007874	PYR/PP interface [polypeptide binding]; other site
1218933007875	dimer interface [polypeptide binding]; other site
1218933007876	TPP binding site [chemical binding]; other site
1218933007877	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1218933007878	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1218933007879	TPP-binding site [chemical binding]; other site
1218933007880	dimer interface [polypeptide binding]; other site
1218933007881	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1218933007882	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1218933007883	TM-ABC transporter signature motif; other site
1218933007884	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1218933007885	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1218933007886	Walker A/P-loop; other site
1218933007887	ATP binding site [chemical binding]; other site
1218933007888	Q-loop/lid; other site
1218933007889	ABC transporter signature motif; other site
1218933007890	Walker B; other site
1218933007891	D-loop; other site
1218933007892	H-loop/switch region; other site
1218933007893	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1218933007894	Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054
1218933007895	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1218933007896	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
1218933007897	ligand binding site [chemical binding]; other site
1218933007898	dimerization interface [polypeptide binding]; other site
1218933007899	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1218933007900	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1218933007901	active site
1218933007902	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1218933007903	dimerization interface [polypeptide binding]; other site
1218933007904	active site
1218933007905	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
1218933007906	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1218933007907	peptide binding site [polypeptide binding]; other site
1218933007908	aconitate hydratase; Validated; Region: PRK09277
1218933007909	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1218933007910	substrate binding site [chemical binding]; other site
1218933007911	ligand binding site [chemical binding]; other site
1218933007912	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1218933007913	substrate binding site [chemical binding]; other site
1218933007914	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1218933007915	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1218933007916	glutathionine S-transferase; Provisional; Region: PRK10542
1218933007917	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
1218933007918	C-terminal domain interface [polypeptide binding]; other site
1218933007919	GSH binding site (G-site) [chemical binding]; other site
1218933007920	dimer interface [polypeptide binding]; other site
1218933007921	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
1218933007922	N-terminal domain interface [polypeptide binding]; other site
1218933007923	dimer interface [polypeptide binding]; other site
1218933007924	substrate binding pocket (H-site) [chemical binding]; other site
1218933007925	pyridoxamine kinase; Validated; Region: PRK05756
1218933007926	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1218933007927	dimer interface [polypeptide binding]; other site
1218933007928	pyridoxal binding site [chemical binding]; other site
1218933007929	ATP binding site [chemical binding]; other site
1218933007930	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1218933007931	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1218933007932	active site
1218933007933	HIGH motif; other site
1218933007934	dimer interface [polypeptide binding]; other site
1218933007935	KMSKS motif; other site
1218933007936	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1218933007937	RNA binding surface [nucleotide binding]; other site
1218933007938	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
1218933007939	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1218933007940	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1218933007941	lysozyme inhibitor; Provisional; Region: PRK11372
1218933007942	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
1218933007943	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
1218933007944	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
1218933007945	transcriptional regulator SlyA; Provisional; Region: PRK03573
1218933007946	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1218933007947	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1218933007948	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1218933007949	dimer interface [polypeptide binding]; other site
1218933007950	active site
1218933007951	metal binding site [ion binding]; metal-binding site
1218933007952	glutathione binding site [chemical binding]; other site
1218933007953	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1218933007954	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
1218933007955	dimer interface [polypeptide binding]; other site
1218933007956	catalytic site [active]
1218933007957	putative active site [active]
1218933007958	putative substrate binding site [chemical binding]; other site
1218933007959	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
1218933007960	putative GSH binding site [chemical binding]; other site
1218933007961	catalytic residues [active]
1218933007962	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1218933007963	NlpC/P60 family; Region: NLPC_P60; pfam00877
1218933007964	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
1218933007965	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1218933007966	DNA binding site [nucleotide binding]
1218933007967	domain linker motif; other site
1218933007968	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
1218933007969	dimerization interface [polypeptide binding]; other site
1218933007970	ligand binding site [chemical binding]; other site
1218933007971	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
1218933007972	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933007973	S-adenosylmethionine binding site [chemical binding]; other site
1218933007974	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
1218933007975	Lumazine binding domain; Region: Lum_binding; pfam00677
1218933007976	Lumazine binding domain; Region: Lum_binding; pfam00677
1218933007977	multidrug efflux protein; Reviewed; Region: PRK01766
1218933007978	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1218933007979	cation binding site [ion binding]; other site
1218933007980	urea carboxylase; Region: urea_carbox; TIGR02712
1218933007981	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1218933007982	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1218933007983	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1218933007984	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
1218933007985	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1218933007986	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1218933007987	carboxyltransferase (CT) interaction site; other site
1218933007988	biotinylation site [posttranslational modification]; other site
1218933007989	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
1218933007990	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
1218933007991	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
1218933007992	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
1218933007993	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1218933007994	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1218933007995	Walker A/P-loop; other site
1218933007996	ATP binding site [chemical binding]; other site
1218933007997	Q-loop/lid; other site
1218933007998	ABC transporter signature motif; other site
1218933007999	Walker B; other site
1218933008000	D-loop; other site
1218933008001	H-loop/switch region; other site
1218933008002	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1218933008003	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1218933008004	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
1218933008005	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1218933008006	MarR family; Region: MarR_2; cl17246
1218933008007	Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977
1218933008008	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
1218933008009	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
1218933008010	dimer interface [polypeptide binding]; other site
1218933008011	active site
1218933008012	heme binding site [chemical binding]; other site
1218933008013	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
1218933008014	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1218933008015	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1218933008016	putative active site [active]
1218933008017	putative metal binding site [ion binding]; other site
1218933008018	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1218933008019	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1218933008020	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1218933008021	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1218933008022	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1218933008023	active site
1218933008024	motif I; other site
1218933008025	motif II; other site
1218933008026	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1218933008027	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1218933008028	transcriptional regulator NarP; Provisional; Region: PRK10403
1218933008029	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933008030	active site
1218933008031	phosphorylation site [posttranslational modification]
1218933008032	intermolecular recognition site; other site
1218933008033	dimerization interface [polypeptide binding]; other site
1218933008034	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1218933008035	DNA binding residues [nucleotide binding]
1218933008036	dimerization interface [polypeptide binding]; other site
1218933008037	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
1218933008038	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
1218933008039	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933008040	dimerization interface [polypeptide binding]; other site
1218933008041	Histidine kinase; Region: HisKA_3; pfam07730
1218933008042	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933008043	ATP binding site [chemical binding]; other site
1218933008044	Mg2+ binding site [ion binding]; other site
1218933008045	G-X-G motif; other site
1218933008046	ferredoxin-type protein; Provisional; Region: PRK10194
1218933008047	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1218933008048	NapD protein; Region: NapD; cl01163
1218933008049	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
1218933008050	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1218933008051	[4Fe-4S] binding site [ion binding]; other site
1218933008052	molybdopterin cofactor binding site; other site
1218933008053	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1218933008054	molybdopterin cofactor binding site; other site
1218933008055	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
1218933008056	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
1218933008057	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
1218933008058	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1218933008059	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1218933008060	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153
1218933008061	cytochrome c-type protein NapC; Provisional; Region: PRK10617
1218933008062	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
1218933008063	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
1218933008064	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
1218933008065	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1218933008066	binding surface
1218933008067	TPR motif; other site
1218933008068	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
1218933008069	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
1218933008070	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1218933008071	catalytic residues [active]
1218933008072	central insert; other site
1218933008073	c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353
1218933008074	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165
1218933008075	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
1218933008076	heme exporter protein CcmC; Region: ccmC; TIGR01191
1218933008077	heme exporter protein CcmB; Region: ccmB; TIGR01190
1218933008078	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
1218933008079	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
1218933008080	Walker A/P-loop; other site
1218933008081	ATP binding site [chemical binding]; other site
1218933008082	Q-loop/lid; other site
1218933008083	ABC transporter signature motif; other site
1218933008084	Walker B; other site
1218933008085	D-loop; other site
1218933008086	H-loop/switch region; other site
1218933008087	formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370
1218933008088	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1218933008089	binding surface
1218933008090	TPR motif; other site
1218933008091	formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144
1218933008092	heme lyase subunit NrfE; Provisional; Region: PRK10369
1218933008093	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
1218933008094	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
1218933008095	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
1218933008096	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
1218933008097	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
1218933008098	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
1218933008099	active site
1218933008100	N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294
1218933008101	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
1218933008102	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1218933008103	Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471
1218933008104	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
1218933008105	trimer interface; other site
1218933008106	sugar binding site [chemical binding]; other site
1218933008107	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1218933008108	beta-galactosidase; Region: BGL; TIGR03356
1218933008109	PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824
1218933008110	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1218933008111	active site turn [active]
1218933008112	phosphorylation site [posttranslational modification]
1218933008113	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1218933008114	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1218933008115	HPr interaction site; other site
1218933008116	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1218933008117	active site
1218933008118	phosphorylation site [posttranslational modification]
1218933008119	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1218933008120	CAT RNA binding domain; Region: CAT_RBD; smart01061
1218933008121	PRD domain; Region: PRD; pfam00874
1218933008122	PRD domain; Region: PRD; pfam00874
1218933008123	pyruvate kinase; Provisional; Region: PRK09206
1218933008124	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
1218933008125	domain interfaces; other site
1218933008126	active site
1218933008127	murein lipoprotein; Provisional; Region: PRK15396
1218933008128	L,D-transpeptidase; Provisional; Region: PRK10190
1218933008129	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1218933008130	cysteine desufuration protein SufE; Provisional; Region: PRK09296
1218933008131	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1218933008132	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1218933008133	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1218933008134	catalytic residue [active]
1218933008135	cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948
1218933008136	FeS assembly protein SufD; Region: sufD; TIGR01981
1218933008137	cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580
1218933008138	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1218933008139	Walker A/P-loop; other site
1218933008140	ATP binding site [chemical binding]; other site
1218933008141	Q-loop/lid; other site
1218933008142	ABC transporter signature motif; other site
1218933008143	Walker B; other site
1218933008144	D-loop; other site
1218933008145	H-loop/switch region; other site
1218933008146	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
1218933008147	putative ABC transporter; Region: ycf24; CHL00085
1218933008148	iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504
1218933008149	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1218933008150	CoenzymeA binding site [chemical binding]; other site
1218933008151	subunit interaction site [polypeptide binding]; other site
1218933008152	PHB binding site; other site
1218933008153	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1218933008154	FAD binding domain; Region: FAD_binding_4; pfam01565
1218933008155	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1218933008156	putative inner membrane protein; Provisional; Region: PRK10983
1218933008157	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1218933008158	thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461
1218933008159	ApbE family; Region: ApbE; pfam02424
1218933008160	phosphoenolpyruvate synthase; Validated; Region: PRK06464
1218933008161	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1218933008162	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1218933008163	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1218933008164	PEP synthetase regulatory protein; Provisional; Region: PRK05339
1218933008165	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
1218933008166	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1218933008167	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
1218933008168	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
1218933008169	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
1218933008170	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
1218933008171	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1218933008172	putative hemin binding site; other site
1218933008173	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1218933008174	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1218933008175	ABC-ATPase subunit  interface; other site
1218933008176	dimer interface [polypeptide binding]; other site
1218933008177	putative PBP binding regions; other site
1218933008178	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
1218933008179	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1218933008180	Walker A/P-loop; other site
1218933008181	ATP binding site [chemical binding]; other site
1218933008182	Q-loop/lid; other site
1218933008183	ABC transporter signature motif; other site
1218933008184	Walker B; other site
1218933008185	D-loop; other site
1218933008186	H-loop/switch region; other site
1218933008187	hypothetical protein; Validated; Region: PRK00029
1218933008188	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1218933008189	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
1218933008190	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
1218933008191	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1218933008192	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1218933008193	NlpC/P60 family; Region: NLPC_P60; pfam00877
1218933008194	vitamin B12-transporter ATPase; Provisional; Region: PRK03695
1218933008195	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1218933008196	Walker A/P-loop; other site
1218933008197	ATP binding site [chemical binding]; other site
1218933008198	Q-loop/lid; other site
1218933008199	ABC transporter signature motif; other site
1218933008200	Walker B; other site
1218933008201	D-loop; other site
1218933008202	H-loop/switch region; other site
1218933008203	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1218933008204	catalytic residues [active]
1218933008205	dimer interface [polypeptide binding]; other site
1218933008206	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1218933008207	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1218933008208	ABC-ATPase subunit  interface; other site
1218933008209	dimer interface [polypeptide binding]; other site
1218933008210	putative PBP binding regions; other site
1218933008211	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1218933008212	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933008213	S-adenosylmethionine binding site [chemical binding]; other site
1218933008214	Cupin domain; Region: Cupin_2; cl17218
1218933008215	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1218933008216	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1218933008217	ligand binding site [chemical binding]; other site
1218933008218	flexible hinge region; other site
1218933008219	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1218933008220	NAD-dependent deacetylase; Provisional; Region: PRK00481
1218933008221	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
1218933008222	NAD+ binding site [chemical binding]; other site
1218933008223	substrate binding site [chemical binding]; other site
1218933008224	Zn binding site [ion binding]; other site
1218933008225	fructokinase; Reviewed; Region: PRK09557
1218933008226	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1218933008227	nucleotide binding site [chemical binding]; other site
1218933008228	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
1218933008229	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1218933008230	FtsX-like permease family; Region: FtsX; pfam02687
1218933008231	lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629
1218933008232	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1218933008233	Walker A/P-loop; other site
1218933008234	ATP binding site [chemical binding]; other site
1218933008235	Q-loop/lid; other site
1218933008236	ABC transporter signature motif; other site
1218933008237	Walker B; other site
1218933008238	D-loop; other site
1218933008239	H-loop/switch region; other site
1218933008240	outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814
1218933008241	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1218933008242	FtsX-like permease family; Region: FtsX; pfam02687
1218933008243	transcription-repair coupling factor; Provisional; Region: PRK10689
1218933008244	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1218933008245	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1218933008246	ATP binding site [chemical binding]; other site
1218933008247	putative Mg++ binding site [ion binding]; other site
1218933008248	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1218933008249	nucleotide binding region [chemical binding]; other site
1218933008250	ATP-binding site [chemical binding]; other site
1218933008251	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1218933008252	putative chaperone; Provisional; Region: PRK11678
1218933008253	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
1218933008254	nucleotide binding site [chemical binding]; other site
1218933008255	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1218933008256	SBD interface [polypeptide binding]; other site
1218933008257	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1218933008258	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1218933008259	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933008260	putative substrate translocation pore; other site
1218933008261	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1218933008262	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1218933008263	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933008264	putative substrate translocation pore; other site
1218933008265	hypothetical protein; Provisional; Region: PRK11280
1218933008266	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1218933008267	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1218933008268	hypothetical protein; Provisional; Region: PRK04940
1218933008269	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1218933008270	beta-hexosaminidase; Provisional; Region: PRK05337
1218933008271	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1218933008272	thiamine kinase; Region: ycfN_thiK; TIGR02721
1218933008273	active site
1218933008274	substrate binding site [chemical binding]; other site
1218933008275	ATP binding site [chemical binding]; other site
1218933008276	Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417
1218933008277	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
1218933008278	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
1218933008279	putative dimer interface [polypeptide binding]; other site
1218933008280	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
1218933008281	nucleotide binding site/active site [active]
1218933008282	HIT family signature motif; other site
1218933008283	catalytic residue [active]
1218933008284	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933008285	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1218933008286	putative substrate translocation pore; other site
1218933008287	Helix-turn-helix domain; Region: HTH_31; pfam13560
1218933008288	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
1218933008289	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1218933008290	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1218933008291	active site turn [active]
1218933008292	phosphorylation site [posttranslational modification]
1218933008293	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1218933008294	active site
1218933008295	DNA polymerase III subunit delta'; Validated; Region: PRK07993
1218933008296	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
1218933008297	thymidylate kinase; Validated; Region: tmk; PRK00698
1218933008298	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1218933008299	TMP-binding site; other site
1218933008300	ATP-binding site [chemical binding]; other site
1218933008301	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
1218933008302	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1218933008303	dimerization interface [polypeptide binding]; other site
1218933008304	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1218933008305	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
1218933008306	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933008307	catalytic residue [active]
1218933008308	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
1218933008309	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1218933008310	dimer interface [polypeptide binding]; other site
1218933008311	active site
1218933008312	acyl carrier protein; Provisional; Region: acpP; PRK00982
1218933008313	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1218933008314	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1218933008315	NAD(P) binding site [chemical binding]; other site
1218933008316	homotetramer interface [polypeptide binding]; other site
1218933008317	homodimer interface [polypeptide binding]; other site
1218933008318	active site
1218933008319	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1218933008320	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1218933008321	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1218933008322	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1218933008323	dimer interface [polypeptide binding]; other site
1218933008324	active site
1218933008325	CoA binding pocket [chemical binding]; other site
1218933008326	putative phosphate acyltransferase; Provisional; Region: PRK05331
1218933008327	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
1218933008328	hypothetical protein; Provisional; Region: PRK11193
1218933008329	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1218933008330	dimer interface [polypeptide binding]; other site
1218933008331	active site
1218933008332	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
1218933008333	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1218933008334	RNA binding surface [nucleotide binding]; other site
1218933008335	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1218933008336	active site
1218933008337	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
1218933008338	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1218933008339	homodimer interface [polypeptide binding]; other site
1218933008340	oligonucleotide binding site [chemical binding]; other site
1218933008341	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
1218933008342	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1218933008343	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
1218933008344	active site
1218933008345	substrate binding pocket [chemical binding]; other site
1218933008346	dimer interface [polypeptide binding]; other site
1218933008347	DNA damage-inducible protein I; Provisional; Region: PRK10597
1218933008348	biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301
1218933008349	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1218933008350	hypothetical protein; Provisional; Region: PRK03757
1218933008351	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
1218933008352	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1218933008353	active site residue [active]
1218933008354	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1218933008355	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1218933008356	active site
1218933008357	FMN binding site [chemical binding]; other site
1218933008358	substrate binding site [chemical binding]; other site
1218933008359	homotetramer interface [polypeptide binding]; other site
1218933008360	catalytic residue [active]
1218933008361	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1218933008362	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1218933008363	putative acyl-acceptor binding pocket; other site
1218933008364	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1218933008365	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
1218933008366	Ligand binding site; other site
1218933008367	DXD motif; other site
1218933008368	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
1218933008369	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433
1218933008370	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1218933008371	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1218933008372	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1218933008373	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1218933008374	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1218933008375	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933008376	dimer interface [polypeptide binding]; other site
1218933008377	putative CheW interface [polypeptide binding]; other site
1218933008378	Protein of unknown function (DUF2566); Region: DUF2566; pfam10753
1218933008379	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1218933008380	Ligand Binding Site [chemical binding]; other site
1218933008381	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933008382	Coenzyme A binding pocket [chemical binding]; other site
1218933008383	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1218933008384	Isochorismatase family; Region: Isochorismatase; pfam00857
1218933008385	catalytic triad [active]
1218933008386	conserved cis-peptide bond; other site
1218933008387	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
1218933008388	nudix motif; other site
1218933008389	Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798
1218933008390	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1218933008391	YccA-like proteins; Region: YccA_like; cd10433
1218933008392	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
1218933008393	sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342
1218933008394	acylphosphatase; Provisional; Region: PRK14426
1218933008395	heat shock protein HspQ; Provisional; Region: PRK14129
1218933008396	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
1218933008397	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437
1218933008398	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
1218933008399	active site
1218933008400	dimer interfaces [polypeptide binding]; other site
1218933008401	catalytic residues [active]
1218933008402	DNA helicase IV; Provisional; Region: helD; PRK11054
1218933008403	DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462
1218933008404	Part of AAA domain; Region: AAA_19; pfam13245
1218933008405	Family description; Region: UvrD_C_2; pfam13538
1218933008406	Predicted membrane protein [Function unknown]; Region: COG3304
1218933008407	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1218933008408	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1218933008409	TIGR01666 family membrane protein; Region: YCCS
1218933008410	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
1218933008411	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1218933008412	TfoX N-terminal domain; Region: TfoX_N; pfam04993
1218933008413	TfoX C-terminal domain; Region: TfoX_C; pfam04994
1218933008414	SOS cell division inhibitor; Provisional; Region: PRK10595
1218933008415	outer membrane protein A; Reviewed; Region: PRK10808
1218933008416	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
1218933008417	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1218933008418	ligand binding site [chemical binding]; other site
1218933008419	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
1218933008420	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
1218933008421	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1218933008422	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
1218933008423	active site 1 [active]
1218933008424	dimer interface [polypeptide binding]; other site
1218933008425	active site 2 [active]
1218933008426	Protein of unknown function (DUF533); Region: DUF533; pfam04391
1218933008427	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
1218933008428	putative metal binding site [ion binding]; other site
1218933008429	choline dehydrogenase; Validated; Region: PRK02106
1218933008430	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1218933008431	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
1218933008432	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
1218933008433	tetrameric interface [polypeptide binding]; other site
1218933008434	NAD binding site [chemical binding]; other site
1218933008435	catalytic residues [active]
1218933008436	transcriptional regulator BetI; Validated; Region: PRK00767
1218933008437	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1218933008438	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1218933008439	choline transport protein BetT; Provisional; Region: PRK09928
1218933008440	hypothetical protein; Provisional; Region: PRK09273
1218933008441	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
1218933008442	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
1218933008443	hypothetical protein; Provisional; Region: PRK10536
1218933008444	flagella biosynthesis protein FliZ; Provisional; Region: PRK11582
1218933008445	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
1218933008446	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1218933008447	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1218933008448	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1218933008449	DNA binding residues [nucleotide binding]
1218933008450	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1218933008451	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933008452	S-adenosylmethionine binding site [chemical binding]; other site
1218933008453	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933008454	Coenzyme A binding pocket [chemical binding]; other site
1218933008455	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1218933008456	active site
1218933008457	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1218933008458	active site
1218933008459	WbqC-like protein family; Region: WbqC; pfam08889
1218933008460	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1218933008461	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1218933008462	inhibitor-cofactor binding pocket; inhibition site
1218933008463	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933008464	catalytic residue [active]
1218933008465	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933008466	S-adenosylmethionine binding site [chemical binding]; other site
1218933008467	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
1218933008468	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1218933008469	TPR motif; other site
1218933008470	binding surface
1218933008471	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
1218933008472	flagellin; Reviewed; Region: PRK08869
1218933008473	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1218933008474	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1218933008475	flagellar capping protein; Reviewed; Region: fliD; PRK08032
1218933008476	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
1218933008477	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
1218933008478	flagellar protein FliS; Validated; Region: fliS; PRK05685
1218933008479	Flagellar protein FliT; Region: FliT; cl05125
1218933008480	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
1218933008481	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
1218933008482	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
1218933008483	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
1218933008484	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
1218933008485	FliG C-terminal domain; Region: FliG_C; pfam01706
1218933008486	flagellar assembly protein H; Validated; Region: fliH; PRK05687
1218933008487	Flagellar assembly protein FliH; Region: FliH; pfam02108
1218933008488	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960
1218933008489	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
1218933008490	Walker A motif/ATP binding site; other site
1218933008491	Walker B motif; other site
1218933008492	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
1218933008493	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
1218933008494	Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777
1218933008495	Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144
1218933008496	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
1218933008497	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
1218933008498	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1218933008499	flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963
1218933008500	flagellar motor switch protein; Validated; Region: fliN; PRK05698
1218933008501	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
1218933008502	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
1218933008503	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
1218933008504	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
1218933008505	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027
1218933008506	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1218933008507	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147
1218933008508	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1218933008509	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
1218933008510	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
1218933008511	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1218933008512	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
1218933008513	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
1218933008514	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
1218933008515	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
1218933008516	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
1218933008517	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1218933008518	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1218933008519	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
1218933008520	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1218933008521	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1218933008522	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
1218933008523	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1218933008524	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
1218933008525	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1218933008526	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
1218933008527	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
1218933008528	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
1218933008529	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
1218933008530	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1218933008531	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1218933008532	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
1218933008533	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
1218933008534	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
1218933008535	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1218933008536	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
1218933008537	anti-sigma28 factor FlgM; Provisional; Region: PRK10810
1218933008538	Flagellar biosynthesis/type III secretory pathway chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3418
1218933008539	Flagellar protein FlhE; Region: FlhE; pfam06366
1218933008540	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
1218933008541	FHIPEP family; Region: FHIPEP; pfam00771
1218933008542	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK12468
1218933008543	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
1218933008544	chemotaxis regulator CheZ; Provisional; Region: PRK11166
1218933008545	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
1218933008546	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933008547	active site
1218933008548	phosphorylation site [posttranslational modification]
1218933008549	intermolecular recognition site; other site
1218933008550	dimerization interface [polypeptide binding]; other site
1218933008551	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
1218933008552	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933008553	active site
1218933008554	phosphorylation site [posttranslational modification]
1218933008555	intermolecular recognition site; other site
1218933008556	dimerization interface [polypeptide binding]; other site
1218933008557	CheB methylesterase; Region: CheB_methylest; pfam01339
1218933008558	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
1218933008559	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1218933008560	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933008561	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
1218933008562	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
1218933008563	dimer interface [polypeptide binding]; other site
1218933008564	ligand binding site [chemical binding]; other site
1218933008565	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933008566	dimerization interface [polypeptide binding]; other site
1218933008567	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933008568	dimer interface [polypeptide binding]; other site
1218933008569	putative CheW interface [polypeptide binding]; other site
1218933008570	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1218933008571	putative CheA interaction surface; other site
1218933008572	chemotaxis protein CheA; Provisional; Region: PRK10547
1218933008573	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1218933008574	putative binding surface; other site
1218933008575	active site
1218933008576	CheY binding; Region: CheY-binding; pfam09078
1218933008577	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1218933008578	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933008579	ATP binding site [chemical binding]; other site
1218933008580	Mg2+ binding site [ion binding]; other site
1218933008581	G-X-G motif; other site
1218933008582	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1218933008583	flagellar motor protein MotB; Validated; Region: motB; PRK09041
1218933008584	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1218933008585	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1218933008586	ligand binding site [chemical binding]; other site
1218933008587	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
1218933008588	flagellar motor protein MotA; Validated; Region: PRK09110
1218933008589	transcriptional activator FlhC; Provisional; Region: PRK12722
1218933008590	transcriptional activator FlhD; Provisional; Region: PRK02909
1218933008591	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1218933008592	EamA-like transporter family; Region: EamA; pfam00892
1218933008593	EamA-like transporter family; Region: EamA; pfam00892
1218933008594	Tar ligand binding domain homologue; Region: TarH; pfam02203
1218933008595	ligand binding site [chemical binding]; other site
1218933008596	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933008597	dimerization interface [polypeptide binding]; other site
1218933008598	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933008599	dimer interface [polypeptide binding]; other site
1218933008600	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1218933008601	putative CheW interface [polypeptide binding]; other site
1218933008602	hypothetical protein; Provisional; Region: PRK10708
1218933008603	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
1218933008604	heme-binding site [chemical binding]; other site
1218933008605	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1218933008606	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1218933008607	metal binding site [ion binding]; metal-binding site
1218933008608	active site
1218933008609	I-site; other site
1218933008610	KTSC domain; Region: KTSC; pfam13619
1218933008611	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933008612	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933008613	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1218933008614	putative effector binding pocket; other site
1218933008615	dimerization interface [polypeptide binding]; other site
1218933008616	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1218933008617	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1218933008618	Phage P2 GpU; Region: Phage_P2_GpU; cl01391
1218933008619	Phage tail tube protein FII; Region: Phage_tube; cl01390
1218933008620	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1218933008621	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1218933008622	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1218933008623	GIY-YIG motif/motif A; other site
1218933008624	active site
1218933008625	catalytic site [active]
1218933008626	putative DNA binding site [nucleotide binding]; other site
1218933008627	metal binding site [ion binding]; metal-binding site
1218933008628	UvrB/uvrC motif; Region: UVR; pfam02151
1218933008629	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1218933008630	response regulator; Provisional; Region: PRK09483
1218933008631	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933008632	active site
1218933008633	phosphorylation site [posttranslational modification]
1218933008634	intermolecular recognition site; other site
1218933008635	dimerization interface [polypeptide binding]; other site
1218933008636	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1218933008637	DNA binding residues [nucleotide binding]
1218933008638	dimerization interface [polypeptide binding]; other site
1218933008639	hypothetical protein; Provisional; Region: PRK10613
1218933008640	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
1218933008641	Sigma-S stabilisation anti-adaptor protein; Region: Anti-adapt_IraP; cl11681
1218933008642	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933008643	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1218933008644	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1218933008645	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1218933008646	catalytic site [active]
1218933008647	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933008648	putative substrate translocation pore; other site
1218933008649	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
1218933008650	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1218933008651	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1218933008652	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1218933008653	HlyD family secretion protein; Region: HlyD_3; pfam13437
1218933008654	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1218933008655	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1218933008656	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1218933008657	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1218933008658	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1218933008659	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1218933008660	catalytic residue [active]
1218933008661	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1218933008662	GTP-binding protein LepA; Provisional; Region: PRK05433
1218933008663	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1218933008664	G1 box; other site
1218933008665	putative GEF interaction site [polypeptide binding]; other site
1218933008666	GTP/Mg2+ binding site [chemical binding]; other site
1218933008667	Switch I region; other site
1218933008668	G2 box; other site
1218933008669	G3 box; other site
1218933008670	Switch II region; other site
1218933008671	G4 box; other site
1218933008672	G5 box; other site
1218933008673	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1218933008674	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1218933008675	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1218933008676	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1218933008677	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1218933008678	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1218933008679	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1218933008680	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
1218933008681	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1218933008682	galactonate dehydratase; Provisional; Region: PRK14017
1218933008683	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1218933008684	active site pocket [active]
1218933008685	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1218933008686	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1218933008687	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1218933008688	HlyD family secretion protein; Region: HlyD_3; pfam13437
1218933008689	MltA-interacting protein MipA; Region: MipA; cl01504
1218933008690	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1218933008691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933008692	active site
1218933008693	phosphorylation site [posttranslational modification]
1218933008694	intermolecular recognition site; other site
1218933008695	dimerization interface [polypeptide binding]; other site
1218933008696	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1218933008697	DNA binding site [nucleotide binding]
1218933008698	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1218933008699	HAMP domain; Region: HAMP; pfam00672
1218933008700	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1218933008701	dimer interface [polypeptide binding]; other site
1218933008702	phosphorylation site [posttranslational modification]
1218933008703	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933008704	ATP binding site [chemical binding]; other site
1218933008705	Mg2+ binding site [ion binding]; other site
1218933008706	G-X-G motif; other site
1218933008707	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1218933008708	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1218933008709	substrate binding pocket [chemical binding]; other site
1218933008710	membrane-bound complex binding site; other site
1218933008711	hinge residues; other site
1218933008712	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
1218933008713	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1218933008714	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933008715	dimer interface [polypeptide binding]; other site
1218933008716	conserved gate region; other site
1218933008717	putative PBP binding loops; other site
1218933008718	ABC-ATPase subunit interface; other site
1218933008719	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1218933008720	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933008721	dimer interface [polypeptide binding]; other site
1218933008722	conserved gate region; other site
1218933008723	putative PBP binding loops; other site
1218933008724	ABC-ATPase subunit interface; other site
1218933008725	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1218933008726	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933008727	Walker A/P-loop; other site
1218933008728	ATP binding site [chemical binding]; other site
1218933008729	Q-loop/lid; other site
1218933008730	ABC transporter signature motif; other site
1218933008731	Walker B; other site
1218933008732	D-loop; other site
1218933008733	H-loop/switch region; other site
1218933008734	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1218933008735	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
1218933008736	homodimer interface [polypeptide binding]; other site
1218933008737	substrate-cofactor binding pocket; other site
1218933008738	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933008739	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
1218933008740	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1218933008741	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1218933008742	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1218933008743	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1218933008744	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1218933008745	dimer interface [polypeptide binding]; other site
1218933008746	phosphorylation site [posttranslational modification]
1218933008747	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933008748	ATP binding site [chemical binding]; other site
1218933008749	Mg2+ binding site [ion binding]; other site
1218933008750	G-X-G motif; other site
1218933008751	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
1218933008752	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933008753	active site
1218933008754	phosphorylation site [posttranslational modification]
1218933008755	intermolecular recognition site; other site
1218933008756	dimerization interface [polypeptide binding]; other site
1218933008757	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1218933008758	DNA binding site [nucleotide binding]
1218933008759	MltA-interacting protein MipA; Region: MipA; cl01504
1218933008760	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1218933008761	active site
1218933008762	iron coordination sites [ion binding]; other site
1218933008763	substrate binding pocket [chemical binding]; other site
1218933008764	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1218933008765	Helix-turn-helix domain; Region: HTH_18; pfam12833
1218933008766	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933008767	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1218933008768	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1218933008769	catalytic triad [active]
1218933008770	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
1218933008771	putative transcriptional regulator; Provisional; Region: PRK11640
1218933008772	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1218933008773	N-acetyltransferase; Region: Acetyltransf_2; cl00949
1218933008774	HAMP domain; Region: HAMP; pfam00672
1218933008775	dimerization interface [polypeptide binding]; other site
1218933008776	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1218933008777	dimer interface [polypeptide binding]; other site
1218933008778	phosphorylation site [posttranslational modification]
1218933008779	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933008780	ATP binding site [chemical binding]; other site
1218933008781	Mg2+ binding site [ion binding]; other site
1218933008782	G-X-G motif; other site
1218933008783	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1218933008784	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933008785	intermolecular recognition site; other site
1218933008786	active site
1218933008787	dimerization interface [polypeptide binding]; other site
1218933008788	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1218933008789	DNA binding site [nucleotide binding]
1218933008790	multidrug efflux system protein MdtE; Provisional; Region: PRK09859
1218933008791	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1218933008792	HlyD family secretion protein; Region: HlyD_3; pfam13437
1218933008793	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1218933008794	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933008795	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1218933008796	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1218933008797	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1218933008798	active site
1218933008799	FMN binding site [chemical binding]; other site
1218933008800	substrate binding site [chemical binding]; other site
1218933008801	homotetramer interface [polypeptide binding]; other site
1218933008802	catalytic residue [active]
1218933008803	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1218933008804	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
1218933008805	putative N- and C-terminal domain interface [polypeptide binding]; other site
1218933008806	putative active site [active]
1218933008807	MgATP binding site [chemical binding]; other site
1218933008808	catalytic site [active]
1218933008809	metal binding site [ion binding]; metal-binding site
1218933008810	putative xylulose binding site [chemical binding]; other site
1218933008811	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1218933008812	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171
1218933008813	putative ligand binding site [chemical binding]; other site
1218933008814	putative NAD binding site [chemical binding]; other site
1218933008815	catalytic site [active]
1218933008816	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1218933008817	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1218933008818	substrate binding site [chemical binding]; other site
1218933008819	ATP binding site [chemical binding]; other site
1218933008820	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1218933008821	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1218933008822	TM-ABC transporter signature motif; other site
1218933008823	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1218933008824	TM-ABC transporter signature motif; other site
1218933008825	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1218933008826	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1218933008827	Walker A/P-loop; other site
1218933008828	ATP binding site [chemical binding]; other site
1218933008829	Q-loop/lid; other site
1218933008830	ABC transporter signature motif; other site
1218933008831	Walker B; other site
1218933008832	D-loop; other site
1218933008833	H-loop/switch region; other site
1218933008834	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1218933008835	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
1218933008836	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1218933008837	putative ligand binding site [chemical binding]; other site
1218933008838	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
1218933008839	Cupin domain; Region: Cupin_2; cl17218
1218933008840	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
1218933008841	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1218933008842	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1218933008843	hypothetical protein; Provisional; Region: PRK09956
1218933008844	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1218933008845	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1218933008846	active site
1218933008847	SAM binding site [chemical binding]; other site
1218933008848	homodimer interface [polypeptide binding]; other site
1218933008849	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1218933008850	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1218933008851	[4Fe-4S] binding site [ion binding]; other site
1218933008852	molybdopterin cofactor binding site; other site
1218933008853	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1218933008854	molybdopterin cofactor binding site; other site
1218933008855	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1218933008856	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1218933008857	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1218933008858	nitrite reductase subunit NirD; Provisional; Region: PRK14989
1218933008859	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1218933008860	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1218933008861	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
1218933008862	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1218933008863	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1218933008864	Walker A/P-loop; other site
1218933008865	ATP binding site [chemical binding]; other site
1218933008866	Q-loop/lid; other site
1218933008867	ABC transporter signature motif; other site
1218933008868	Walker B; other site
1218933008869	D-loop; other site
1218933008870	H-loop/switch region; other site
1218933008871	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1218933008872	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933008873	dimer interface [polypeptide binding]; other site
1218933008874	conserved gate region; other site
1218933008875	putative PBP binding loops; other site
1218933008876	ABC-ATPase subunit interface; other site
1218933008877	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1218933008878	NMT1-like family; Region: NMT1_2; pfam13379
1218933008879	Nitrate and nitrite sensing; Region: NIT; pfam08376
1218933008880	ANTAR domain; Region: ANTAR; pfam03861
1218933008881	Phage Tail Collar Domain; Region: Collar; pfam07484
1218933008882	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
1218933008883	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1218933008884	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
1218933008885	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1218933008886	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1218933008887	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
1218933008888	Domain of unknown function (DUF202); Region: DUF202; cl09954
1218933008889	Domain of unknown function (DUF202); Region: DUF202; pfam02656
1218933008890	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
1218933008891	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
1218933008892	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1218933008893	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933008894	DNA-binding site [nucleotide binding]; DNA binding site
1218933008895	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1218933008896	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933008897	homodimer interface [polypeptide binding]; other site
1218933008898	catalytic residue [active]
1218933008899	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1218933008900	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1218933008901	catalytic triad [active]
1218933008902	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
1218933008903	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
1218933008904	Trp docking motif [polypeptide binding]; other site
1218933008905	putative active site [active]
1218933008906	sigma70 family sigma factor YlaC; Region: YlaC; pfam10777
1218933008907	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1218933008908	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1218933008909	NAD(P) binding site [chemical binding]; other site
1218933008910	putative active site [active]
1218933008911	putative heme utilization carrier protein HutX; Region: HutX; TIGR04108
1218933008912	coproporphyrinogen III oxidase; Provisional; Region: PRK09058
1218933008913	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1218933008914	FeS/SAM binding site; other site
1218933008915	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
1218933008916	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933008917	N-terminal plug; other site
1218933008918	ligand-binding site [chemical binding]; other site
1218933008919	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1218933008920	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1218933008921	intersubunit interface [polypeptide binding]; other site
1218933008922	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1218933008923	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933008924	Walker A/P-loop; other site
1218933008925	ATP binding site [chemical binding]; other site
1218933008926	Q-loop/lid; other site
1218933008927	ABC transporter signature motif; other site
1218933008928	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1218933008929	Walker B; other site
1218933008930	D-loop; other site
1218933008931	H-loop/switch region; other site
1218933008932	ABC transporter; Region: ABC_tran_2; pfam12848
1218933008933	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1218933008934	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1218933008935	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1218933008936	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1218933008937	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1218933008938	PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007
1218933008939	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1218933008940	active site turn [active]
1218933008941	phosphorylation site [posttranslational modification]
1218933008942	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1218933008943	trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933
1218933008944	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1218933008945	Ca binding site [ion binding]; other site
1218933008946	active site
1218933008947	catalytic site [active]
1218933008948	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1218933008949	hypothetical protein; Provisional; Region: PRK10404
1218933008950	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1218933008951	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1218933008952	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1218933008953	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1218933008954	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1218933008955	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1218933008956	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1218933008957	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1218933008958	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
1218933008959	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1218933008960	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
1218933008961	4Fe-4S binding domain; Region: Fer4; pfam00037
1218933008962	4Fe-4S binding domain; Region: Fer4; pfam00037
1218933008963	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1218933008964	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1218933008965	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
1218933008966	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1218933008967	catalytic loop [active]
1218933008968	iron binding site [ion binding]; other site
1218933008969	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1218933008970	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
1218933008971	[4Fe-4S] binding site [ion binding]; other site
1218933008972	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
1218933008973	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
1218933008974	SLBB domain; Region: SLBB; pfam10531
1218933008975	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
1218933008976	NADH dehydrogenase subunit E; Validated; Region: PRK07539
1218933008977	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1218933008978	putative dimer interface [polypeptide binding]; other site
1218933008979	[2Fe-2S] cluster binding site [ion binding]; other site
1218933008980	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
1218933008981	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
1218933008982	NADH dehydrogenase subunit D; Validated; Region: PRK06075
1218933008983	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
1218933008984	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
1218933008985	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
1218933008986	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933008987	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
1218933008988	putative dimerization interface [polypeptide binding]; other site
1218933008989	aminotransferase AlaT; Validated; Region: PRK09265
1218933008990	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1218933008991	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933008992	homodimer interface [polypeptide binding]; other site
1218933008993	catalytic residue [active]
1218933008994	5'-nucleotidase; Provisional; Region: PRK03826
1218933008995	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1218933008996	transmembrane helices; other site
1218933008997	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1218933008998	TrkA-C domain; Region: TrkA_C; pfam02080
1218933008999	TrkA-C domain; Region: TrkA_C; pfam02080
1218933009000	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1218933009001	putative phosphatase; Provisional; Region: PRK11587
1218933009002	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1218933009003	motif II; other site
1218933009004	hypothetical protein; Validated; Region: PRK05445
1218933009005	hypothetical protein; Provisional; Region: PRK01816
1218933009006	propionate/acetate kinase; Provisional; Region: PRK12379
1218933009007	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1218933009008	phosphate acetyltransferase; Reviewed; Region: PRK05632
1218933009009	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1218933009010	DRTGG domain; Region: DRTGG; pfam07085
1218933009011	phosphate acetyltransferase; Region: pta; TIGR00651
1218933009012	Uncharacterized integral membrane protein [Function unknown]; Region: COG3739
1218933009013	NUDIX hydrolase YfcD; Provisional; Region: PRK15393
1218933009014	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697
1218933009015	nudix motif; other site
1218933009016	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1218933009017	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1218933009018	active site
1218933009019	metal binding site [ion binding]; metal-binding site
1218933009020	homotetramer interface [polypeptide binding]; other site
1218933009021	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
1218933009022	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1218933009023	C-terminal domain interface [polypeptide binding]; other site
1218933009024	GSH binding site (G-site) [chemical binding]; other site
1218933009025	dimer interface [polypeptide binding]; other site
1218933009026	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
1218933009027	N-terminal domain interface [polypeptide binding]; other site
1218933009028	putative dimer interface [polypeptide binding]; other site
1218933009029	active site
1218933009030	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1218933009031	homooctamer interface [polypeptide binding]; other site
1218933009032	active site
1218933009033	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1218933009034	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
1218933009035	putative NAD(P) binding site [chemical binding]; other site
1218933009036	putative active site [active]
1218933009037	histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619
1218933009038	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1218933009039	Walker A/P-loop; other site
1218933009040	ATP binding site [chemical binding]; other site
1218933009041	Q-loop/lid; other site
1218933009042	ABC transporter signature motif; other site
1218933009043	Walker B; other site
1218933009044	D-loop; other site
1218933009045	H-loop/switch region; other site
1218933009046	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1218933009047	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933009048	dimer interface [polypeptide binding]; other site
1218933009049	conserved gate region; other site
1218933009050	putative PBP binding loops; other site
1218933009051	ABC-ATPase subunit interface; other site
1218933009052	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1218933009053	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933009054	dimer interface [polypeptide binding]; other site
1218933009055	conserved gate region; other site
1218933009056	putative PBP binding loops; other site
1218933009057	ABC-ATPase subunit interface; other site
1218933009058	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
1218933009059	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1218933009060	substrate binding pocket [chemical binding]; other site
1218933009061	membrane-bound complex binding site; other site
1218933009062	hinge residues; other site
1218933009063	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
1218933009064	Flavoprotein; Region: Flavoprotein; pfam02441
1218933009065	amidophosphoribosyltransferase; Provisional; Region: PRK09246
1218933009066	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1218933009067	active site
1218933009068	tetramer interface [polypeptide binding]; other site
1218933009069	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1218933009070	active site
1218933009071	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1218933009072	colicin V production protein; Provisional; Region: PRK10845
1218933009073	cell division protein DedD; Provisional; Region: PRK11633
1218933009074	Sporulation related domain; Region: SPOR; pfam05036
1218933009075	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
1218933009076	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1218933009077	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1218933009078	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1218933009079	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1218933009080	hypothetical protein; Provisional; Region: PRK10847
1218933009081	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1218933009082	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1218933009083	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1218933009084	dimerization interface 3.5A [polypeptide binding]; other site
1218933009085	active site
1218933009086	putative semialdehyde dehydrogenase; Provisional; Region: PRK08040
1218933009087	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1218933009088	erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438
1218933009089	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
1218933009090	ligand binding site [chemical binding]; other site
1218933009091	NAD binding site [chemical binding]; other site
1218933009092	catalytic site [active]
1218933009093	homodimer interface [polypeptide binding]; other site
1218933009094	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1218933009095	EamA-like transporter family; Region: EamA; pfam00892
1218933009096	flagella biosynthesis regulator; Provisional; Region: flk; PRK10715
1218933009097	flagella biosynthesis regulator; Provisional; Region: flk; PRK10715
1218933009098	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
1218933009099	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1218933009100	dimer interface [polypeptide binding]; other site
1218933009101	active site
1218933009102	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
1218933009103	Uncharacterized conserved protein [Function unknown]; Region: COG4121
1218933009104	YfcL protein; Region: YfcL; pfam08891
1218933009105	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101
1218933009106	hypothetical protein; Provisional; Region: PRK10621
1218933009107	Predicted permeases [General function prediction only]; Region: COG0730
1218933009108	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
1218933009109	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
1218933009110	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1218933009111	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1218933009112	Tetramer interface [polypeptide binding]; other site
1218933009113	active site
1218933009114	FMN-binding site [chemical binding]; other site
1218933009115	HemK family putative methylases; Region: hemK_fam; TIGR00536
1218933009116	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933009117	S-adenosylmethionine binding site [chemical binding]; other site
1218933009118	hypothetical protein; Provisional; Region: PRK04946
1218933009119	Smr domain; Region: Smr; pfam01713
1218933009120	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1218933009121	catalytic core [active]
1218933009122	Spore Coat Protein U domain; Region: SCPU; pfam05229
1218933009123	Spore Coat Protein U domain; Region: SCPU; pfam05229
1218933009124	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1218933009125	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1218933009126	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1218933009127	PapC N-terminal domain; Region: PapC_N; pfam13954
1218933009128	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1218933009129	PapC C-terminal domain; Region: PapC_C; pfam13953
1218933009130	Spore Coat Protein U domain; Region: SCPU; pfam05229
1218933009131	Spore Coat Protein U domain; Region: SCPU; pfam05229
1218933009132	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
1218933009133	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1218933009134	substrate binding site [chemical binding]; other site
1218933009135	oxyanion hole (OAH) forming residues; other site
1218933009136	trimer interface [polypeptide binding]; other site
1218933009137	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1218933009138	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1218933009139	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1218933009140	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
1218933009141	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1218933009142	dimer interface [polypeptide binding]; other site
1218933009143	active site
1218933009144	MarR family; Region: MarR_2; cl17246
1218933009145	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1218933009146	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933009147	S-adenosylmethionine binding site [chemical binding]; other site
1218933009148	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691
1218933009149	long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716
1218933009150	short chain dehydrogenase; Provisional; Region: PRK06500
1218933009151	classical (c) SDRs; Region: SDR_c; cd05233
1218933009152	NAD(P) binding site [chemical binding]; other site
1218933009153	active site
1218933009154	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933009155	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933009156	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1218933009157	putative effector binding pocket; other site
1218933009158	dimerization interface [polypeptide binding]; other site
1218933009159	malate:quinone oxidoreductase; Validated; Region: PRK05257
1218933009160	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1218933009161	ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091
1218933009162	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1218933009163	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1218933009164	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933009165	Coenzyme A binding pocket [chemical binding]; other site
1218933009166	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
1218933009167	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1218933009168	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1218933009169	putative DNA binding site [nucleotide binding]; other site
1218933009170	putative Zn2+ binding site [ion binding]; other site
1218933009171	AsnC family; Region: AsnC_trans_reg; pfam01037
1218933009172	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1218933009173	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933009174	putative substrate translocation pore; other site
1218933009175	Necrosis inducing protein (NPP1); Region: NPP1; pfam05630
1218933009176	Serine hydrolase; Region: Ser_hydrolase; pfam06821
1218933009177	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1218933009178	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
1218933009179	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1218933009180	ATP binding site [chemical binding]; other site
1218933009181	putative Mg++ binding site [ion binding]; other site
1218933009182	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1218933009183	nucleotide binding region [chemical binding]; other site
1218933009184	ATP-binding site [chemical binding]; other site
1218933009185	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
1218933009186	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1218933009187	molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537
1218933009188	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1218933009189	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933009190	Walker A/P-loop; other site
1218933009191	ATP binding site [chemical binding]; other site
1218933009192	Q-loop/lid; other site
1218933009193	ABC transporter signature motif; other site
1218933009194	Walker B; other site
1218933009195	D-loop; other site
1218933009196	H-loop/switch region; other site
1218933009197	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1218933009198	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1218933009199	ABC-ATPase subunit  interface; other site
1218933009200	dimer interface [polypeptide binding]; other site
1218933009201	putative PBP binding regions; other site
1218933009202	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
1218933009203	putative ligand binding residues [chemical binding]; other site
1218933009204	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1218933009205	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1218933009206	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1218933009207	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1218933009208	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1218933009209	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1218933009210	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
1218933009211	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
1218933009212	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
1218933009213	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
1218933009214	GspL periplasmic domain; Region: GspL_C; pfam12693
1218933009215	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
1218933009216	type II secretion system protein J; Region: gspJ; TIGR01711
1218933009217	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
1218933009218	type II secretion system protein I; Region: gspI; TIGR01707
1218933009219	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
1218933009220	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
1218933009221	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
1218933009222	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
1218933009223	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
1218933009224	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
1218933009225	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
1218933009226	type II secretion system protein F; Region: GspF; TIGR02120
1218933009227	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1218933009228	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1218933009229	type II secretion system protein E; Region: type_II_gspE; TIGR02533
1218933009230	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1218933009231	Walker A motif; other site
1218933009232	ATP binding site [chemical binding]; other site
1218933009233	Walker B motif; other site
1218933009234	type II secretion system protein D; Region: type_II_gspD; TIGR02517
1218933009235	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1218933009236	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1218933009237	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1218933009238	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1218933009239	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
1218933009240	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
1218933009241	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1218933009242	Interdomain contacts; other site
1218933009243	Cytokine receptor motif; other site
1218933009244	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1218933009245	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
1218933009246	Amb_all domain; Region: Amb_all; smart00656
1218933009247	Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898
1218933009248	aminotransferase; Validated; Region: PRK08175
1218933009249	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1218933009250	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933009251	homodimer interface [polypeptide binding]; other site
1218933009252	catalytic residue [active]
1218933009253	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
1218933009254	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
1218933009255	active site
1218933009256	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1218933009257	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1218933009258	homodimer interface [polypeptide binding]; other site
1218933009259	substrate-cofactor binding pocket; other site
1218933009260	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933009261	catalytic residue [active]
1218933009262	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
1218933009263	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
1218933009264	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1218933009265	Methyltransferase domain; Region: Methyltransf_27; pfam13708
1218933009266	hypothetical protein; Provisional; Region: PRK07190
1218933009267	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1218933009268	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1218933009269	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1218933009270	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1218933009271	substrate binding pocket [chemical binding]; other site
1218933009272	active site
1218933009273	iron coordination sites [ion binding]; other site
1218933009274	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
1218933009275	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1218933009276	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
1218933009277	acyl-activating enzyme (AAE) consensus motif; other site
1218933009278	AMP binding site [chemical binding]; other site
1218933009279	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
1218933009280	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
1218933009281	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933009282	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933009283	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
1218933009284	putative effector binding pocket; other site
1218933009285	putative dimerization interface [polypeptide binding]; other site
1218933009286	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1218933009287	PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255
1218933009288	active site
1218933009289	methionine cluster; other site
1218933009290	phosphorylation site [posttranslational modification]
1218933009291	metal binding site [ion binding]; metal-binding site
1218933009292	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1218933009293	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1218933009294	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1218933009295	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933009296	dimer interface [polypeptide binding]; other site
1218933009297	conserved gate region; other site
1218933009298	ABC-ATPase subunit interface; other site
1218933009299	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933009300	dimer interface [polypeptide binding]; other site
1218933009301	conserved gate region; other site
1218933009302	putative PBP binding loops; other site
1218933009303	ABC-ATPase subunit interface; other site
1218933009304	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1218933009305	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1218933009306	Walker A/P-loop; other site
1218933009307	ATP binding site [chemical binding]; other site
1218933009308	Q-loop/lid; other site
1218933009309	ABC transporter signature motif; other site
1218933009310	Walker B; other site
1218933009311	D-loop; other site
1218933009312	H-loop/switch region; other site
1218933009313	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
1218933009314	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
1218933009315	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
1218933009316	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1218933009317	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
1218933009318	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
1218933009319	putative active site [active]
1218933009320	putative catalytic site [active]
1218933009321	putative Zn binding site [ion binding]; other site
1218933009322	bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125
1218933009323	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
1218933009324	active site
1218933009325	substrate binding site [chemical binding]; other site
1218933009326	cosubstrate binding site; other site
1218933009327	catalytic site [active]
1218933009328	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
1218933009329	active site
1218933009330	hexamer interface [polypeptide binding]; other site
1218933009331	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
1218933009332	NAD binding site [chemical binding]; other site
1218933009333	substrate binding site [chemical binding]; other site
1218933009334	active site
1218933009335	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1218933009336	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1218933009337	Ligand binding site; other site
1218933009338	Putative Catalytic site; other site
1218933009339	DXD motif; other site
1218933009340	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1218933009341	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1218933009342	inhibitor-cofactor binding pocket; inhibition site
1218933009343	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933009344	catalytic residue [active]
1218933009345	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
1218933009346	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1218933009347	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1218933009348	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1218933009349	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1218933009350	metal binding site [ion binding]; metal-binding site
1218933009351	active site
1218933009352	I-site; other site
1218933009353	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
1218933009354	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1218933009355	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1218933009356	homodimer interface [polypeptide binding]; other site
1218933009357	NADP binding site [chemical binding]; other site
1218933009358	substrate binding site [chemical binding]; other site
1218933009359	ribosome-associated protein; Provisional; Region: PRK11507
1218933009360	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1218933009361	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1218933009362	active site
1218933009363	HIGH motif; other site
1218933009364	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1218933009365	KMSKS motif; other site
1218933009366	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
1218933009367	tRNA binding surface [nucleotide binding]; other site
1218933009368	anticodon binding site; other site
1218933009369	DoxX; Region: DoxX; pfam07681
1218933009370	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
1218933009371	substrate binding site [chemical binding]; other site
1218933009372	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1218933009373	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1218933009374	putative active site [active]
1218933009375	putative metal binding site [ion binding]; other site
1218933009376	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1218933009377	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1218933009378	ATP-grasp domain; Region: ATP-grasp; pfam02222
1218933009379	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1218933009380	serine transporter; Region: stp; TIGR00814
1218933009381	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1218933009382	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1218933009383	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1218933009384	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1218933009385	non-specific DNA binding site [nucleotide binding]; other site
1218933009386	salt bridge; other site
1218933009387	sequence-specific DNA binding site [nucleotide binding]; other site
1218933009388	phosphate transporter ATP-binding protein; Provisional; Region: PRK14236
1218933009389	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1218933009390	Walker A/P-loop; other site
1218933009391	ATP binding site [chemical binding]; other site
1218933009392	Q-loop/lid; other site
1218933009393	ABC transporter signature motif; other site
1218933009394	Walker B; other site
1218933009395	D-loop; other site
1218933009396	H-loop/switch region; other site
1218933009397	ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985
1218933009398	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1218933009399	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933009400	dimer interface [polypeptide binding]; other site
1218933009401	conserved gate region; other site
1218933009402	putative PBP binding loops; other site
1218933009403	ABC-ATPase subunit interface; other site
1218933009404	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
1218933009405	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933009406	dimer interface [polypeptide binding]; other site
1218933009407	conserved gate region; other site
1218933009408	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933009409	dimer interface [polypeptide binding]; other site
1218933009410	conserved gate region; other site
1218933009411	putative PBP binding loops; other site
1218933009412	ABC-ATPase subunit interface; other site
1218933009413	polyphosphate kinase; Provisional; Region: PRK05443
1218933009414	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1218933009415	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1218933009416	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
1218933009417	domain interface [polypeptide binding]; other site
1218933009418	active site
1218933009419	catalytic site [active]
1218933009420	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
1218933009421	domain interface [polypeptide binding]; other site
1218933009422	active site
1218933009423	catalytic site [active]
1218933009424	exopolyphosphatase; Provisional; Region: PRK10854
1218933009425	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1218933009426	nucleotide binding site [chemical binding]; other site
1218933009427	Putative motility protein; Region: YjfB_motility; pfam14070
1218933009428	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1218933009429	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1218933009430	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1218933009431	putative Zn2+ binding site [ion binding]; other site
1218933009432	putative DNA binding site [nucleotide binding]; other site
1218933009433	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1218933009434	MgtE intracellular N domain; Region: MgtE_N; smart00924
1218933009435	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1218933009436	Divalent cation transporter; Region: MgtE; cl00786
1218933009437	galactokinase; Provisional; Region: PRK05101
1218933009438	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1218933009439	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1218933009440	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
1218933009441	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
1218933009442	dimer interface [polypeptide binding]; other site
1218933009443	active site
1218933009444	DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727
1218933009445	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1218933009446	DNA binding site [nucleotide binding]
1218933009447	domain linker motif; other site
1218933009448	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
1218933009449	dimerization interface (closed form) [polypeptide binding]; other site
1218933009450	ligand binding site [chemical binding]; other site
1218933009451	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
1218933009452	trimer interface; other site
1218933009453	sugar binding site [chemical binding]; other site
1218933009454	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1218933009455	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1218933009456	Walker A/P-loop; other site
1218933009457	ATP binding site [chemical binding]; other site
1218933009458	Q-loop/lid; other site
1218933009459	ABC transporter signature motif; other site
1218933009460	Walker B; other site
1218933009461	D-loop; other site
1218933009462	H-loop/switch region; other site
1218933009463	TOBE domain; Region: TOBE_2; pfam08402
1218933009464	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1218933009465	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1218933009466	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933009467	dimer interface [polypeptide binding]; other site
1218933009468	conserved gate region; other site
1218933009469	ABC-ATPase subunit interface; other site
1218933009470	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1218933009471	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933009472	dimer interface [polypeptide binding]; other site
1218933009473	conserved gate region; other site
1218933009474	putative PBP binding loops; other site
1218933009475	ABC-ATPase subunit interface; other site
1218933009476	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
1218933009477	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1218933009478	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1218933009479	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1218933009480	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
1218933009481	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1218933009482	active site turn [active]
1218933009483	phosphorylation site [posttranslational modification]
1218933009484	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1218933009485	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1218933009486	active site
1218933009487	catalytic tetrad [active]
1218933009488	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1218933009489	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1218933009490	Nucleoside recognition; Region: Gate; pfam07670
1218933009491	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1218933009492	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
1218933009493	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1218933009494	HlyD family secretion protein; Region: HlyD_3; pfam13437
1218933009495	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
1218933009496	Protein export membrane protein; Region: SecD_SecF; cl14618
1218933009497	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
1218933009498	putative transporter; Provisional; Region: PRK10504
1218933009499	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933009500	putative substrate translocation pore; other site
1218933009501	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
1218933009502	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933009503	dimerization interface [polypeptide binding]; other site
1218933009504	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1218933009505	dimer interface [polypeptide binding]; other site
1218933009506	phosphorylation site [posttranslational modification]
1218933009507	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933009508	ATP binding site [chemical binding]; other site
1218933009509	Mg2+ binding site [ion binding]; other site
1218933009510	G-X-G motif; other site
1218933009511	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
1218933009512	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933009513	active site
1218933009514	phosphorylation site [posttranslational modification]
1218933009515	intermolecular recognition site; other site
1218933009516	dimerization interface [polypeptide binding]; other site
1218933009517	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1218933009518	DNA binding site [nucleotide binding]
1218933009519	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1218933009520	trimer interface [polypeptide binding]; other site
1218933009521	active site
1218933009522	substrate binding site [chemical binding]; other site
1218933009523	CoA binding site [chemical binding]; other site
1218933009524	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1218933009525	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1218933009526	Coenzyme A binding pocket [chemical binding]; other site
1218933009527	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
1218933009528	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
1218933009529	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
1218933009530	putative dimer interface [polypeptide binding]; other site
1218933009531	N-terminal domain interface [polypeptide binding]; other site
1218933009532	putative substrate binding pocket (H-site) [chemical binding]; other site
1218933009533	putative protease; Provisional; Region: PRK15452
1218933009534	Peptidase family U32; Region: Peptidase_U32; pfam01136
1218933009535	lipid kinase; Reviewed; Region: PRK13054
1218933009536	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1218933009537	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
1218933009538	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1218933009539	dimer interface [polypeptide binding]; other site
1218933009540	substrate binding site [chemical binding]; other site
1218933009541	ATP binding site [chemical binding]; other site
1218933009542	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1218933009543	substrate binding site [chemical binding]; other site
1218933009544	multimerization interface [polypeptide binding]; other site
1218933009545	ATP binding site [chemical binding]; other site
1218933009546	Superfamily II helicase [General function prediction only]; Region: COG1204
1218933009547	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1218933009548	ATP binding site [chemical binding]; other site
1218933009549	putative Mg++ binding site [ion binding]; other site
1218933009550	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1218933009551	nucleotide binding region [chemical binding]; other site
1218933009552	ATP-binding site [chemical binding]; other site
1218933009553	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
1218933009554	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1218933009555	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1218933009556	putative NAD(P) binding site [chemical binding]; other site
1218933009557	putative substrate binding site [chemical binding]; other site
1218933009558	catalytic Zn binding site [ion binding]; other site
1218933009559	structural Zn binding site [ion binding]; other site
1218933009560	dimer interface [polypeptide binding]; other site
1218933009561	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1218933009562	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1218933009563	metal binding site [ion binding]; metal-binding site
1218933009564	active site
1218933009565	I-site; other site
1218933009566	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1218933009567	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933009568	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933009569	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
1218933009570	putative dimerization interface [polypeptide binding]; other site
1218933009571	Protein of unknown function (DUF3750); Region: DUF3750; pfam12570
1218933009572	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
1218933009573	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1218933009574	YCII-related domain; Region: YCII; cl00999
1218933009575	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
1218933009576	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1218933009577	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
1218933009578	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1218933009579	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1218933009580	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
1218933009581	conserved cys residue [active]
1218933009582	HTH domain; Region: HTH_11; cl17392
1218933009583	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933009584	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1218933009585	non-specific DNA binding site [nucleotide binding]; other site
1218933009586	salt bridge; other site
1218933009587	sequence-specific DNA binding site [nucleotide binding]; other site
1218933009588	Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693
1218933009589	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
1218933009590	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
1218933009591	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1218933009592	GMP synthase; Reviewed; Region: guaA; PRK00074
1218933009593	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1218933009594	AMP/PPi binding site [chemical binding]; other site
1218933009595	candidate oxyanion hole; other site
1218933009596	catalytic triad [active]
1218933009597	potential glutamine specificity residues [chemical binding]; other site
1218933009598	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1218933009599	ATP Binding subdomain [chemical binding]; other site
1218933009600	Ligand Binding sites [chemical binding]; other site
1218933009601	Dimerization subdomain; other site
1218933009602	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1218933009603	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1218933009604	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1218933009605	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1218933009606	active site
1218933009607	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1218933009608	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1218933009609	generic binding surface II; other site
1218933009610	generic binding surface I; other site
1218933009611	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1218933009612	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1218933009613	active site
1218933009614	Zn binding site [ion binding]; other site
1218933009615	Protein of unknown function (DUF1407); Region: DUF1407; pfam07191
1218933009616	Cupin domain; Region: Cupin_2; cl17218
1218933009617	Predicted permeases [General function prediction only]; Region: COG0679
1218933009618	GTP-binding protein Der; Reviewed; Region: PRK00093
1218933009619	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1218933009620	G1 box; other site
1218933009621	GTP/Mg2+ binding site [chemical binding]; other site
1218933009622	Switch I region; other site
1218933009623	G2 box; other site
1218933009624	Switch II region; other site
1218933009625	G3 box; other site
1218933009626	G4 box; other site
1218933009627	G5 box; other site
1218933009628	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1218933009629	G1 box; other site
1218933009630	GTP/Mg2+ binding site [chemical binding]; other site
1218933009631	Switch I region; other site
1218933009632	G2 box; other site
1218933009633	G3 box; other site
1218933009634	Switch II region; other site
1218933009635	G4 box; other site
1218933009636	G5 box; other site
1218933009637	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
1218933009638	Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276
1218933009639	Trp docking motif [polypeptide binding]; other site
1218933009640	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
1218933009641	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
1218933009642	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1218933009643	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1218933009644	dimer interface [polypeptide binding]; other site
1218933009645	motif 1; other site
1218933009646	active site
1218933009647	motif 2; other site
1218933009648	motif 3; other site
1218933009649	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1218933009650	anticodon binding site; other site
1218933009651	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1218933009652	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1218933009653	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1218933009654	cytoskeletal protein RodZ; Provisional; Region: PRK10856
1218933009655	Helix-turn-helix domain; Region: HTH_25; pfam13413
1218933009656	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1218933009657	Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063
1218933009658	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1218933009659	binding surface
1218933009660	TPR motif; other site
1218933009661	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1218933009662	binding surface
1218933009663	TPR motif; other site
1218933009664	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
1218933009665	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1218933009666	FeS/SAM binding site; other site
1218933009667	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1218933009668	active site
1218933009669	multimer interface [polypeptide binding]; other site
1218933009670	PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005
1218933009671	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1218933009672	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1218933009673	active site turn [active]
1218933009674	phosphorylation site [posttranslational modification]
1218933009675	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1218933009676	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
1218933009677	NAD binding site [chemical binding]; other site
1218933009678	sugar binding site [chemical binding]; other site
1218933009679	divalent metal binding site [ion binding]; other site
1218933009680	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1218933009681	dimer interface [polypeptide binding]; other site
1218933009682	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
1218933009683	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1218933009684	active site residue [active]
1218933009685	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1218933009686	active site residue [active]
1218933009687	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1218933009688	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557
1218933009689	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1218933009690	putative active site [active]
1218933009691	enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611
1218933009692	aminopeptidase B; Provisional; Region: PRK05015
1218933009693	Peptidase; Region: DUF3663; pfam12404
1218933009694	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1218933009695	interface (dimer of trimers) [polypeptide binding]; other site
1218933009696	Substrate-binding/catalytic site; other site
1218933009697	Zn-binding sites [ion binding]; other site
1218933009698	hypothetical protein; Provisional; Region: PRK10721
1218933009699	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1218933009700	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1218933009701	catalytic loop [active]
1218933009702	iron binding site [ion binding]; other site
1218933009703	chaperone protein HscA; Provisional; Region: hscA; PRK05183
1218933009704	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
1218933009705	nucleotide binding site [chemical binding]; other site
1218933009706	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1218933009707	SBD interface [polypeptide binding]; other site
1218933009708	co-chaperone HscB; Provisional; Region: hscB; PRK05014
1218933009709	DnaJ domain; Region: DnaJ; pfam00226
1218933009710	HSP70 interaction site [polypeptide binding]; other site
1218933009711	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
1218933009712	iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502
1218933009713	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1218933009714	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1218933009715	trimerization site [polypeptide binding]; other site
1218933009716	active site
1218933009717	cysteine desulfurase; Provisional; Region: PRK14012
1218933009718	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1218933009719	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1218933009720	catalytic residue [active]
1218933009721	DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857
1218933009722	Rrf2 family protein; Region: rrf2_super; TIGR00738
1218933009723	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
1218933009724	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1218933009725	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1218933009726	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1218933009727	active site
1218933009728	dimerization interface [polypeptide binding]; other site
1218933009729	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1218933009730	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1218933009731	intersubunit interface [polypeptide binding]; other site
1218933009732	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1218933009733	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1218933009734	ABC-ATPase subunit  interface; other site
1218933009735	dimer interface [polypeptide binding]; other site
1218933009736	putative PBP binding regions; other site
1218933009737	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1218933009738	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1218933009739	Walker A/P-loop; other site
1218933009740	ATP binding site [chemical binding]; other site
1218933009741	Q-loop/lid; other site
1218933009742	ABC transporter signature motif; other site
1218933009743	Walker B; other site
1218933009744	D-loop; other site
1218933009745	H-loop/switch region; other site
1218933009746	HAMP domain; Region: HAMP; pfam00672
1218933009747	dimerization interface [polypeptide binding]; other site
1218933009748	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933009749	dimer interface [polypeptide binding]; other site
1218933009750	putative CheW interface [polypeptide binding]; other site
1218933009751	ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048
1218933009752	Periplasmic binding protein TroA_f.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139
1218933009753	putative ligand binding residues [chemical binding]; other site
1218933009754	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
1218933009755	Protein of unknown function (DUF1007); Region: DUF1007; pfam06226
1218933009756	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
1218933009757	MFS_1 like family; Region: MFS_1_like; pfam12832
1218933009758	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1218933009759	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1218933009760	dimer interface [polypeptide binding]; other site
1218933009761	active site
1218933009762	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1218933009763	folate binding site [chemical binding]; other site
1218933009764	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1218933009765	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1218933009766	heme-binding site [chemical binding]; other site
1218933009767	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1218933009768	FAD binding pocket [chemical binding]; other site
1218933009769	FAD binding motif [chemical binding]; other site
1218933009770	phosphate binding motif [ion binding]; other site
1218933009771	beta-alpha-beta structure motif; other site
1218933009772	NAD binding pocket [chemical binding]; other site
1218933009773	Heme binding  pocket [chemical binding]; other site
1218933009774	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1218933009775	active site
1218933009776	catalytic triad [active]
1218933009777	oxyanion hole [active]
1218933009778	Pectinesterase; Region: Pectinesterase; pfam01095
1218933009779	putative pectinesterase; Region: PLN02432; cl01911
1218933009780	nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858
1218933009781	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1218933009782	response regulator GlrR; Provisional; Region: PRK15115
1218933009783	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933009784	active site
1218933009785	phosphorylation site [posttranslational modification]
1218933009786	intermolecular recognition site; other site
1218933009787	dimerization interface [polypeptide binding]; other site
1218933009788	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933009789	Walker A motif; other site
1218933009790	ATP binding site [chemical binding]; other site
1218933009791	Walker B motif; other site
1218933009792	arginine finger; other site
1218933009793	hypothetical protein; Provisional; Region: PRK10722
1218933009794	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1218933009795	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1218933009796	dimer interface [polypeptide binding]; other site
1218933009797	phosphorylation site [posttranslational modification]
1218933009798	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933009799	ATP binding site [chemical binding]; other site
1218933009800	Mg2+ binding site [ion binding]; other site
1218933009801	G-X-G motif; other site
1218933009802	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
1218933009803	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1218933009804	dimerization interface [polypeptide binding]; other site
1218933009805	ATP binding site [chemical binding]; other site
1218933009806	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
1218933009807	dimerization interface [polypeptide binding]; other site
1218933009808	ATP binding site [chemical binding]; other site
1218933009809	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1218933009810	putative active site [active]
1218933009811	catalytic triad [active]
1218933009812	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
1218933009813	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1218933009814	substrate binding pocket [chemical binding]; other site
1218933009815	membrane-bound complex binding site; other site
1218933009816	hinge residues; other site
1218933009817	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1218933009818	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1218933009819	catalytic residue [active]
1218933009820	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1218933009821	nucleoside/Zn binding site; other site
1218933009822	dimer interface [polypeptide binding]; other site
1218933009823	catalytic motif [active]
1218933009824	hypothetical protein; Provisional; Region: PRK11590
1218933009825	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1218933009826	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
1218933009827	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1218933009828	putative active site [active]
1218933009829	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1218933009830	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
1218933009831	HAMP domain; Region: HAMP; pfam00672
1218933009832	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1218933009833	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1218933009834	metal binding site [ion binding]; metal-binding site
1218933009835	active site
1218933009836	I-site; other site
1218933009837	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1218933009838	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933009839	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933009840	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933009841	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933009842	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933009843	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933009844	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933009845	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933009846	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933009847	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933009848	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933009849	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933009850	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1218933009851	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
1218933009852	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1218933009853	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
1218933009854	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1218933009855	putative active site [active]
1218933009856	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1218933009857	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
1218933009858	Walker A/P-loop; other site
1218933009859	ATP binding site [chemical binding]; other site
1218933009860	Q-loop/lid; other site
1218933009861	ABC transporter signature motif; other site
1218933009862	Walker B; other site
1218933009863	D-loop; other site
1218933009864	H-loop/switch region; other site
1218933009865	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1218933009866	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1218933009867	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
1218933009868	HlyD family secretion protein; Region: HlyD_3; pfam13437
1218933009869	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1218933009870	PAS domain; Region: PAS_9; pfam13426
1218933009871	putative active site [active]
1218933009872	heme pocket [chemical binding]; other site
1218933009873	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1218933009874	GAF domain; Region: GAF; pfam01590
1218933009875	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1218933009876	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1218933009877	metal binding site [ion binding]; metal-binding site
1218933009878	active site
1218933009879	I-site; other site
1218933009880	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1218933009881	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1218933009882	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1218933009883	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
1218933009884	active site
1218933009885	hydrophilic channel; other site
1218933009886	dimerization interface [polypeptide binding]; other site
1218933009887	catalytic residues [active]
1218933009888	active site lid [active]
1218933009889	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1218933009890	Recombination protein O N terminal; Region: RecO_N; pfam11967
1218933009891	Recombination protein O C terminal; Region: RecO_C; pfam02565
1218933009892	GTPase Era; Reviewed; Region: era; PRK00089
1218933009893	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1218933009894	G1 box; other site
1218933009895	GTP/Mg2+ binding site [chemical binding]; other site
1218933009896	Switch I region; other site
1218933009897	G2 box; other site
1218933009898	Switch II region; other site
1218933009899	G3 box; other site
1218933009900	G4 box; other site
1218933009901	G5 box; other site
1218933009902	KH domain; Region: KH_2; pfam07650
1218933009903	ribonuclease III; Reviewed; Region: rnc; PRK00102
1218933009904	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1218933009905	dimerization interface [polypeptide binding]; other site
1218933009906	active site
1218933009907	metal binding site [ion binding]; metal-binding site
1218933009908	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1218933009909	dsRNA binding site [nucleotide binding]; other site
1218933009910	signal peptidase I; Provisional; Region: PRK10861
1218933009911	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1218933009912	Catalytic site [active]
1218933009913	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1218933009914	GTP-binding protein LepA; Provisional; Region: PRK05433
1218933009915	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1218933009916	G1 box; other site
1218933009917	putative GEF interaction site [polypeptide binding]; other site
1218933009918	GTP/Mg2+ binding site [chemical binding]; other site
1218933009919	Switch I region; other site
1218933009920	G2 box; other site
1218933009921	G3 box; other site
1218933009922	Switch II region; other site
1218933009923	G4 box; other site
1218933009924	G5 box; other site
1218933009925	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1218933009926	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1218933009927	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1218933009928	SoxR reducing system protein RseC; Provisional; Region: PRK10862
1218933009929	anti-sigma E factor; Provisional; Region: rseB; PRK09455
1218933009930	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
1218933009931	anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863
1218933009932	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
1218933009933	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
1218933009934	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
1218933009935	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1218933009936	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1218933009937	DNA binding residues [nucleotide binding]
1218933009938	L-aspartate oxidase; Provisional; Region: PRK09077
1218933009939	L-aspartate oxidase; Provisional; Region: PRK06175
1218933009940	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1218933009941	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1218933009942	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933009943	S-adenosylmethionine binding site [chemical binding]; other site
1218933009944	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
1218933009945	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1218933009946	ATP binding site [chemical binding]; other site
1218933009947	Mg++ binding site [ion binding]; other site
1218933009948	motif III; other site
1218933009949	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1218933009950	nucleotide binding region [chemical binding]; other site
1218933009951	ATP-binding site [chemical binding]; other site
1218933009952	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
1218933009953	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1218933009954	ligand binding site [chemical binding]; other site
1218933009955	active site
1218933009956	UGI interface [polypeptide binding]; other site
1218933009957	catalytic site [active]
1218933009958	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1218933009959	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1218933009960	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1218933009961	active site
1218933009962	HIGH motif; other site
1218933009963	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1218933009964	active site
1218933009965	KMSKS motif; other site
1218933009966	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1218933009967	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
1218933009968	putative active site [active]
1218933009969	putative FMN binding site [chemical binding]; other site
1218933009970	putative substrate binding site [chemical binding]; other site
1218933009971	putative catalytic residue [active]
1218933009972	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1218933009973	active site
1218933009974	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1218933009975	catalytic tetrad [active]
1218933009976	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1218933009977	DoxX; Region: DoxX; pfam07681
1218933009978	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
1218933009979	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
1218933009980	Walker A/P-loop; other site
1218933009981	ATP binding site [chemical binding]; other site
1218933009982	Q-loop/lid; other site
1218933009983	ABC transporter signature motif; other site
1218933009984	Walker B; other site
1218933009985	D-loop; other site
1218933009986	H-loop/switch region; other site
1218933009987	TOBE-like domain; Region: TOBE_3; pfam12857
1218933009988	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1218933009989	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933009990	dimer interface [polypeptide binding]; other site
1218933009991	conserved gate region; other site
1218933009992	putative PBP binding loops; other site
1218933009993	ABC-ATPase subunit interface; other site
1218933009994	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1218933009995	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933009996	dimer interface [polypeptide binding]; other site
1218933009997	conserved gate region; other site
1218933009998	putative PBP binding loops; other site
1218933009999	ABC-ATPase subunit interface; other site
1218933010000	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1218933010001	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1218933010002	substrate binding pocket [chemical binding]; other site
1218933010003	membrane-bound complex binding site; other site
1218933010004	hinge residues; other site
1218933010005	carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477
1218933010006	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
1218933010007	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1218933010008	serine endoprotease; Provisional; Region: PRK10942
1218933010009	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1218933010010	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1218933010011	protein binding site [polypeptide binding]; other site
1218933010012	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1218933010013	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
1218933010014	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1218933010015	Zn2+ binding site [ion binding]; other site
1218933010016	Mg2+ binding site [ion binding]; other site
1218933010017	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1218933010018	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1218933010019	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1218933010020	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
1218933010021	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
1218933010022	cobalamin binding residues [chemical binding]; other site
1218933010023	putative BtuC binding residues; other site
1218933010024	dimer interface [polypeptide binding]; other site
1218933010025	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
1218933010026	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1218933010027	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1218933010028	inhibitor-cofactor binding pocket; inhibition site
1218933010029	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933010030	catalytic residue [active]
1218933010031	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1218933010032	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
1218933010033	putative C-terminal domain interface [polypeptide binding]; other site
1218933010034	putative GSH binding site (G-site) [chemical binding]; other site
1218933010035	putative dimer interface [polypeptide binding]; other site
1218933010036	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
1218933010037	putative N-terminal domain interface [polypeptide binding]; other site
1218933010038	putative dimer interface [polypeptide binding]; other site
1218933010039	putative substrate binding pocket (H-site) [chemical binding]; other site
1218933010040	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1218933010041	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933010042	DNA-binding site [nucleotide binding]; DNA binding site
1218933010043	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1218933010044	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933010045	homodimer interface [polypeptide binding]; other site
1218933010046	catalytic residue [active]
1218933010047	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1218933010048	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1218933010049	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1218933010050	ABC-ATPase subunit  interface; other site
1218933010051	dimer interface [polypeptide binding]; other site
1218933010052	putative PBP binding regions; other site
1218933010053	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1218933010054	ABC-ATPase subunit  interface; other site
1218933010055	dimer interface [polypeptide binding]; other site
1218933010056	putative PBP binding regions; other site
1218933010057	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1218933010058	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1218933010059	siderophore binding site; other site
1218933010060	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
1218933010061	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1218933010062	Walker A/P-loop; other site
1218933010063	ATP binding site [chemical binding]; other site
1218933010064	Q-loop/lid; other site
1218933010065	ABC transporter signature motif; other site
1218933010066	Walker B; other site
1218933010067	D-loop; other site
1218933010068	H-loop/switch region; other site
1218933010069	bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506
1218933010070	Transglycosylase; Region: Transgly; pfam00912
1218933010071	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1218933010072	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
1218933010073	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1218933010074	ATP binding site [chemical binding]; other site
1218933010075	putative Mg++ binding site [ion binding]; other site
1218933010076	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1218933010077	nucleotide binding region [chemical binding]; other site
1218933010078	ATP-binding site [chemical binding]; other site
1218933010079	Helicase associated domain (HA2); Region: HA2; pfam04408
1218933010080	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
1218933010081	2'-5' RNA ligase; Provisional; Region: PRK15124
1218933010082	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1218933010083	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1218933010084	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
1218933010085	RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778
1218933010086	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
1218933010087	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
1218933010088	active site
1218933010089	nucleotide binding site [chemical binding]; other site
1218933010090	HIGH motif; other site
1218933010091	KMSKS motif; other site
1218933010092	poly(A) polymerase I; Provisional; Region: pcnB; PRK11623
1218933010093	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1218933010094	active site
1218933010095	NTP binding site [chemical binding]; other site
1218933010096	metal binding triad [ion binding]; metal-binding site
1218933010097	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1218933010098	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
1218933010099	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1218933010100	catalytic center binding site [active]
1218933010101	ATP binding site [chemical binding]; other site
1218933010102	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1218933010103	oligomerization interface [polypeptide binding]; other site
1218933010104	active site
1218933010105	metal binding site [ion binding]; metal-binding site
1218933010106	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1218933010107	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1218933010108	active site
1218933010109	ATP-binding site [chemical binding]; other site
1218933010110	pantoate-binding site; other site
1218933010111	HXXH motif; other site
1218933010112	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1218933010113	tetramerization interface [polypeptide binding]; other site
1218933010114	active site
1218933010115	inner membrane transport permease; Provisional; Region: PRK15066
1218933010116	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1218933010117	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1218933010118	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1218933010119	Walker A/P-loop; other site
1218933010120	ATP binding site [chemical binding]; other site
1218933010121	Q-loop/lid; other site
1218933010122	ABC transporter signature motif; other site
1218933010123	Walker B; other site
1218933010124	D-loop; other site
1218933010125	H-loop/switch region; other site
1218933010126	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
1218933010127	active site clefts [active]
1218933010128	zinc binding site [ion binding]; other site
1218933010129	dimer interface [polypeptide binding]; other site
1218933010130	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1218933010131	active site
1218933010132	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1218933010133	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933010134	Coenzyme A binding pocket [chemical binding]; other site
1218933010135	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1218933010136	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1218933010137	Walker A/P-loop; other site
1218933010138	ATP binding site [chemical binding]; other site
1218933010139	Q-loop/lid; other site
1218933010140	ABC transporter signature motif; other site
1218933010141	Walker B; other site
1218933010142	D-loop; other site
1218933010143	H-loop/switch region; other site
1218933010144	TOBE domain; Region: TOBE_2; pfam08402
1218933010145	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1218933010146	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933010147	dimer interface [polypeptide binding]; other site
1218933010148	conserved gate region; other site
1218933010149	putative PBP binding loops; other site
1218933010150	ABC-ATPase subunit interface; other site
1218933010151	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1218933010152	Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898
1218933010153	spermidine synthase; Provisional; Region: PRK00811
1218933010154	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933010155	S-adenosylmethionine binding site [chemical binding]; other site
1218933010156	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
1218933010157	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1218933010158	catalytic residues [active]
1218933010159	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1218933010160	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
1218933010161	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1218933010162	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1218933010163	active site
1218933010164	dimer interface [polypeptide binding]; other site
1218933010165	catalytic residues [active]
1218933010166	effector binding site; other site
1218933010167	R2 peptide binding site; other site
1218933010168	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1218933010169	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1218933010170	dimer interface [polypeptide binding]; other site
1218933010171	putative radical transfer pathway; other site
1218933010172	diiron center [ion binding]; other site
1218933010173	tyrosyl radical; other site
1218933010174	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
1218933010175	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
1218933010176	active site
1218933010177	catalytic site [active]
1218933010178	substrate binding site [chemical binding]; other site
1218933010179	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1218933010180	RNA/DNA hybrid binding site [nucleotide binding]; other site
1218933010181	active site
1218933010182	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1218933010183	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
1218933010184	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1218933010185	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1218933010186	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1218933010187	catalytic residue [active]
1218933010188	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1218933010189	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1218933010190	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1218933010191	hypothetical protein; Provisional; Region: PRK05421
1218933010192	putative catalytic site [active]
1218933010193	putative metal binding site [ion binding]; other site
1218933010194	putative catalytic site [active]
1218933010195	putative phosphate binding site [ion binding]; other site
1218933010196	putative phosphate binding site [ion binding]; other site
1218933010197	putative metal binding site [ion binding]; other site
1218933010198	protein disaggregation chaperone; Provisional; Region: PRK10865
1218933010199	Clp amino terminal domain; Region: Clp_N; pfam02861
1218933010200	Clp amino terminal domain; Region: Clp_N; pfam02861
1218933010201	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933010202	Walker A motif; other site
1218933010203	ATP binding site [chemical binding]; other site
1218933010204	Walker B motif; other site
1218933010205	arginine finger; other site
1218933010206	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933010207	Walker A motif; other site
1218933010208	ATP binding site [chemical binding]; other site
1218933010209	Walker B motif; other site
1218933010210	arginine finger; other site
1218933010211	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1218933010212	hypothetical protein; Provisional; Region: PRK10723
1218933010213	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1218933010214	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
1218933010215	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1218933010216	RNA binding surface [nucleotide binding]; other site
1218933010217	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1218933010218	active site
1218933010219	outer membrane biogenesis protein BamD; Provisional; Region: PRK10866
1218933010220	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1218933010221	30S subunit binding site; other site
1218933010222	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
1218933010223	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
1218933010224	Prephenate dehydratase; Region: PDT; pfam00800
1218933010225	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1218933010226	putative L-Phe binding site [chemical binding]; other site
1218933010227	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
1218933010228	Chorismate mutase type II; Region: CM_2; cl00693
1218933010229	prephenate dehydrogenase; Validated; Region: PRK08507
1218933010230	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
1218933010231	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1218933010232	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
1218933010233	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933010234	active site
1218933010235	phosphorylation site [posttranslational modification]
1218933010236	intermolecular recognition site; other site
1218933010237	dimerization interface [polypeptide binding]; other site
1218933010238	LytTr DNA-binding domain; Region: LytTR; pfam04397
1218933010239	lipoprotein; Provisional; Region: PRK11443
1218933010240	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
1218933010241	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933010242	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1218933010243	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1218933010244	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1218933010245	RimM N-terminal domain; Region: RimM; pfam01782
1218933010246	PRC-barrel domain; Region: PRC; pfam05239
1218933010247	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1218933010248	signal recognition particle protein; Provisional; Region: PRK10867
1218933010249	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1218933010250	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1218933010251	P loop; other site
1218933010252	GTP binding site [chemical binding]; other site
1218933010253	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1218933010254	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
1218933010255	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1218933010256	glutamate--cysteine ligase; Provisional; Region: PRK02107
1218933010257	Predicted membrane protein [Function unknown]; Region: COG1238
1218933010258	fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725
1218933010259	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1218933010260	motif II; other site
1218933010261	carbon storage regulator; Provisional; Region: PRK01712
1218933010262	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1218933010263	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1218933010264	motif 1; other site
1218933010265	active site
1218933010266	motif 2; other site
1218933010267	motif 3; other site
1218933010268	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1218933010269	DHHA1 domain; Region: DHHA1; pfam02272
1218933010270	recombination regulator RecX; Reviewed; Region: recX; PRK00117
1218933010271	recombinase A; Provisional; Region: recA; PRK09354
1218933010272	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1218933010273	hexamer interface [polypeptide binding]; other site
1218933010274	Walker A motif; other site
1218933010275	ATP binding site [chemical binding]; other site
1218933010276	Walker B motif; other site
1218933010277	hypothetical protein; Validated; Region: PRK03661
1218933010278	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
1218933010279	putative hydrophobic ligand binding site [chemical binding]; other site
1218933010280	inner membrane protein; Provisional; Region: PRK10995
1218933010281	Cache domain; Region: Cache_1; pfam02743
1218933010282	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1218933010283	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1218933010284	metal binding site [ion binding]; metal-binding site
1218933010285	active site
1218933010286	I-site; other site
1218933010287	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933010288	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1218933010289	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933010290	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933010291	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1218933010292	putative effector binding pocket; other site
1218933010293	dimerization interface [polypeptide binding]; other site
1218933010294	glutaredoxin 2; Provisional; Region: PRK10387
1218933010295	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1218933010296	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
1218933010297	N-terminal domain interface [polypeptide binding]; other site
1218933010298	Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141
1218933010299	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1218933010300	RHS protein; Region: RHS; pfam03527
1218933010301	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1218933010302	RHS protein; Region: RHS; pfam03527
1218933010303	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1218933010304	RHS Repeat; Region: RHS_repeat; pfam05593
1218933010305	RHS Repeat; Region: RHS_repeat; pfam05593
1218933010306	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1218933010307	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
1218933010308	RHS Repeat; Region: RHS_repeat; pfam05593
1218933010309	RHS Repeat; Region: RHS_repeat; pfam05593
1218933010310	RHS Repeat; Region: RHS_repeat; pfam05593
1218933010311	RHS Repeat; Region: RHS_repeat; pfam05593
1218933010312	RHS protein; Region: RHS; pfam03527
1218933010313	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1218933010314	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
1218933010315	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
1218933010316	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1218933010317	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1218933010318	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1218933010319	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1218933010320	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1218933010321	Uncharacterized conserved protein [Function unknown]; Region: COG4104
1218933010322	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
1218933010323	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1218933010324	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1218933010325	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
1218933010326	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1218933010327	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
1218933010328	ImpA domain protein; Region: DUF3702; pfam12486
1218933010329	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
1218933010330	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1218933010331	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1218933010332	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
1218933010333	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
1218933010334	type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360
1218933010335	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1218933010336	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933010337	Walker A motif; other site
1218933010338	ATP binding site [chemical binding]; other site
1218933010339	Walker B motif; other site
1218933010340	arginine finger; other site
1218933010341	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
1218933010342	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933010343	Walker A motif; other site
1218933010344	ATP binding site [chemical binding]; other site
1218933010345	Walker B motif; other site
1218933010346	arginine finger; other site
1218933010347	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933010348	Walker A motif; other site
1218933010349	ATP binding site [chemical binding]; other site
1218933010350	Walker B motif; other site
1218933010351	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1218933010352	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
1218933010353	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
1218933010354	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
1218933010355	type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352
1218933010356	type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354
1218933010357	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
1218933010358	phosphopeptide binding site; other site
1218933010359	type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347
1218933010360	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
1218933010361	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
1218933010362	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
1218933010363	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
1218933010364	Protein of unknown function (DUF877); Region: DUF877; pfam05943
1218933010365	Protein of unknown function (DUF770); Region: DUF770; pfam05591
1218933010366	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1218933010367	Part of AAA domain; Region: AAA_19; pfam13245
1218933010368	Family description; Region: UvrD_C_2; pfam13538
1218933010369	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
1218933010370	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1218933010371	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1218933010372	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1218933010373	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1218933010374	ATP binding site [chemical binding]; other site
1218933010375	putative Mg++ binding site [ion binding]; other site
1218933010376	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
1218933010377	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
1218933010378	Domain of unknown function (DUF4268); Region: DUF4268; pfam14088
1218933010379	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1218933010380	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1218933010381	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1218933010382	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1218933010383	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1218933010384	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
1218933010385	ligand binding site [chemical binding]; other site
1218933010386	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1218933010387	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1218933010388	ATP binding site [chemical binding]; other site
1218933010389	putative Mg++ binding site [ion binding]; other site
1218933010390	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1218933010391	nucleotide binding region [chemical binding]; other site
1218933010392	ATP-binding site [chemical binding]; other site
1218933010393	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1218933010394	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1218933010395	active site
1218933010396	Int/Topo IB signature motif; other site
1218933010397	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
1218933010398	ADP-ribose binding site [chemical binding]; other site
1218933010399	Protein of unknown function (DUF4065); Region: DUF4065; cl01445
1218933010400	Methyltransferase domain; Region: Methyltransf_27; pfam13708
1218933010401	Protein of unknown function (DUF1219); Region: DUF1219; pfam06755
1218933010402	YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154
1218933010403	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1218933010404	MPN+ (JAMM) motif; other site
1218933010405	Zinc-binding site [ion binding]; other site
1218933010406	TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920
1218933010407	HTH domain; Region: HTH_11; pfam08279
1218933010408	Stage III sporulation protein D; Region: SpoIIID; cl17560
1218933010409	WYL domain; Region: WYL; pfam13280
1218933010410	Predicted GTPase [General function prediction only]; Region: COG3596
1218933010411	YfjP GTPase; Region: YfjP; cd11383
1218933010412	G1 box; other site
1218933010413	GTP/Mg2+ binding site [chemical binding]; other site
1218933010414	Switch I region; other site
1218933010415	G2 box; other site
1218933010416	Switch II region; other site
1218933010417	G3 box; other site
1218933010418	G4 box; other site
1218933010419	G5 box; other site
1218933010420	Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849
1218933010421	Domain of unknown function (DUF1788); Region: DUF1788; pfam08747
1218933010422	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1218933010423	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
1218933010424	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1218933010425	TIGR02687 family protein; Region: TIGR02687
1218933010426	PglZ domain; Region: PglZ; pfam08665
1218933010427	conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653
1218933010428	Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337
1218933010429	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
1218933010430	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
1218933010431	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1218933010432	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1218933010433	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1218933010434	putative catalytic cysteine [active]
1218933010435	gamma-glutamyl kinase; Provisional; Region: PRK05429
1218933010436	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1218933010437	nucleotide binding site [chemical binding]; other site
1218933010438	homotetrameric interface [polypeptide binding]; other site
1218933010439	putative phosphate binding site [ion binding]; other site
1218933010440	putative allosteric binding site; other site
1218933010441	PUA domain; Region: PUA; pfam01472
1218933010442	DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984
1218933010443	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1218933010444	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1218933010445	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1218933010446	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1218933010447	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1218933010448	FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666
1218933010449	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1218933010450	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1218933010451	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1218933010452	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1218933010453	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1218933010454	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
1218933010455	putative substrate binding pocket [chemical binding]; other site
1218933010456	trimer interface [polypeptide binding]; other site
1218933010457	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
1218933010458	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1218933010459	active site
1218933010460	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
1218933010461	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
1218933010462	metal binding site [ion binding]; metal-binding site
1218933010463	dimer interface [polypeptide binding]; other site
1218933010464	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1218933010465	active site
1218933010466	DNA polymerase IV; Validated; Region: PRK02406
1218933010467	DNA binding site [nucleotide binding]
1218933010468	Helix-turn-helix domain; Region: HTH_31; pfam13560
1218933010469	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1218933010470	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933010471	S-adenosylmethionine binding site [chemical binding]; other site
1218933010472	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
1218933010473	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
1218933010474	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1218933010475	putative active site [active]
1218933010476	putative dimer interface [polypeptide binding]; other site
1218933010477	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1218933010478	dimer interface [polypeptide binding]; other site
1218933010479	active site
1218933010480	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
1218933010481	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1218933010482	active site
1218933010483	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
1218933010484	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1218933010485	active site
1218933010486	methylthioribose kinase; Reviewed; Region: mtnK; PRK09550
1218933010487	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
1218933010488	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
1218933010489	PAAR motif; Region: PAAR_motif; cl15808
1218933010490	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
1218933010491	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
1218933010492	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
1218933010493	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
1218933010494	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
1218933010495	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1218933010496	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1218933010497	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
1218933010498	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
1218933010499	Cupin domain; Region: Cupin_2; cl17218
1218933010500	2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691
1218933010501	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1218933010502	G2 box; other site
1218933010503	Switch I region; other site
1218933010504	G3 box; other site
1218933010505	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1218933010506	methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220
1218933010507	intersubunit interface [polypeptide binding]; other site
1218933010508	active site
1218933010509	Zn2+ binding site [ion binding]; other site
1218933010510	methionine aminotransferase; Validated; Region: PRK09082
1218933010511	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1218933010512	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933010513	homodimer interface [polypeptide binding]; other site
1218933010514	catalytic residue [active]
1218933010515	C-N hydrolase family amidase; Provisional; Region: PRK10438
1218933010516	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
1218933010517	putative active site [active]
1218933010518	catalytic triad [active]
1218933010519	dimer interface [polypeptide binding]; other site
1218933010520	multimer interface [polypeptide binding]; other site
1218933010521	allantoate amidohydrolase; Reviewed; Region: PRK09290
1218933010522	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1218933010523	active site
1218933010524	metal binding site [ion binding]; metal-binding site
1218933010525	dimer interface [polypeptide binding]; other site
1218933010526	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1218933010527	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1218933010528	catalytic residue [active]
1218933010529	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1218933010530	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1218933010531	Walker A/P-loop; other site
1218933010532	ATP binding site [chemical binding]; other site
1218933010533	Q-loop/lid; other site
1218933010534	ABC transporter signature motif; other site
1218933010535	Walker B; other site
1218933010536	D-loop; other site
1218933010537	H-loop/switch region; other site
1218933010538	amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726
1218933010539	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933010540	ABC-ATPase subunit interface; other site
1218933010541	putative PBP binding loops; other site
1218933010542	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933010543	dimer interface [polypeptide binding]; other site
1218933010544	conserved gate region; other site
1218933010545	putative PBP binding loops; other site
1218933010546	ABC-ATPase subunit interface; other site
1218933010547	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1218933010548	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1218933010549	substrate binding pocket [chemical binding]; other site
1218933010550	membrane-bound complex binding site; other site
1218933010551	hinge residues; other site
1218933010552	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1218933010553	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1218933010554	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1218933010555	putative active site [active]
1218933010556	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1218933010557	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1218933010558	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
1218933010559	amidase; Provisional; Region: PRK09201
1218933010560	Amidase; Region: Amidase; cl11426
1218933010561	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
1218933010562	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
1218933010563	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1218933010564	glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070
1218933010565	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
1218933010566	Walker A/P-loop; other site
1218933010567	ATP binding site [chemical binding]; other site
1218933010568	Q-loop/lid; other site
1218933010569	ABC transporter signature motif; other site
1218933010570	Walker B; other site
1218933010571	D-loop; other site
1218933010572	H-loop/switch region; other site
1218933010573	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1218933010574	hypothetical protein; Provisional; Region: PRK12495
1218933010575	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
1218933010576	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933010577	dimer interface [polypeptide binding]; other site
1218933010578	conserved gate region; other site
1218933010579	putative PBP binding loops; other site
1218933010580	ABC-ATPase subunit interface; other site
1218933010581	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
1218933010582	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1218933010583	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1218933010584	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
1218933010585	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
1218933010586	CGNR zinc finger; Region: zf-CGNR; pfam11706
1218933010587	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1218933010588	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933010589	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1218933010590	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1218933010591	putative L-valine exporter; Provisional; Region: PRK10408
1218933010592	transcriptional repressor MprA; Provisional; Region: PRK10870
1218933010593	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1218933010594	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
1218933010595	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1218933010596	HlyD family secretion protein; Region: HlyD_3; pfam13437
1218933010597	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1218933010598	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933010599	putative substrate translocation pore; other site
1218933010600	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933010601	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1218933010602	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1218933010603	Nucleoside recognition; Region: Gate; pfam07670
1218933010604	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1218933010605	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
1218933010606	putative methyltransferase; Provisional; Region: PRK10864
1218933010607	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1218933010608	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1218933010609	thioredoxin 2; Provisional; Region: PRK10996
1218933010610	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
1218933010611	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1218933010612	catalytic residues [active]
1218933010613	Uncharacterized conserved protein [Function unknown]; Region: COG3148
1218933010614	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
1218933010615	CoA binding domain; Region: CoA_binding_2; pfam13380
1218933010616	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
1218933010617	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
1218933010618	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1218933010619	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1218933010620	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
1218933010621	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
1218933010622	domain interface [polypeptide binding]; other site
1218933010623	putative active site [active]
1218933010624	catalytic site [active]
1218933010625	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
1218933010626	domain interface [polypeptide binding]; other site
1218933010627	putative active site [active]
1218933010628	catalytic site [active]
1218933010629	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1218933010630	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933010631	putative substrate translocation pore; other site
1218933010632	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
1218933010633	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1218933010634	active site
1218933010635	motif I; other site
1218933010636	motif II; other site
1218933010637	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1218933010638	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1218933010639	Walker A/P-loop; other site
1218933010640	ATP binding site [chemical binding]; other site
1218933010641	Q-loop/lid; other site
1218933010642	ABC transporter signature motif; other site
1218933010643	Walker B; other site
1218933010644	D-loop; other site
1218933010645	H-loop/switch region; other site
1218933010646	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1218933010647	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933010648	dimer interface [polypeptide binding]; other site
1218933010649	conserved gate region; other site
1218933010650	ABC-ATPase subunit interface; other site
1218933010651	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
1218933010652	lipoprotein, YaeC family; Region: TIGR00363
1218933010653	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
1218933010654	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
1218933010655	homodimer interaction site [polypeptide binding]; other site
1218933010656	cofactor binding site; other site
1218933010657	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1218933010658	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1218933010659	dimer interface [polypeptide binding]; other site
1218933010660	motif 1; other site
1218933010661	active site
1218933010662	motif 2; other site
1218933010663	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1218933010664	putative deacylase active site [active]
1218933010665	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1218933010666	active site
1218933010667	motif 3; other site
1218933010668	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1218933010669	anticodon binding site; other site
1218933010670	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
1218933010671	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1218933010672	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1218933010673	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1218933010674	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1218933010675	DNA binding residues [nucleotide binding]
1218933010676	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
1218933010677	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1218933010678	Peptidase family M23; Region: Peptidase_M23; pfam01551
1218933010679	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
1218933010680	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933010681	S-adenosylmethionine binding site [chemical binding]; other site
1218933010682	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
1218933010683	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
1218933010684	Permutation of conserved domain; other site
1218933010685	active site
1218933010686	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1218933010687	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1218933010688	homotrimer interaction site [polypeptide binding]; other site
1218933010689	zinc binding site [ion binding]; other site
1218933010690	CDP-binding sites; other site
1218933010691	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1218933010692	substrate binding site; other site
1218933010693	dimer interface; other site
1218933010694	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
1218933010695	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1218933010696	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1218933010697	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1218933010698	substrate binding pocket [chemical binding]; other site
1218933010699	membrane-bound complex binding site; other site
1218933010700	hinge residues; other site
1218933010701	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933010702	dimer interface [polypeptide binding]; other site
1218933010703	conserved gate region; other site
1218933010704	putative PBP binding loops; other site
1218933010705	ABC-ATPase subunit interface; other site
1218933010706	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1218933010707	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1218933010708	Walker A/P-loop; other site
1218933010709	ATP binding site [chemical binding]; other site
1218933010710	Q-loop/lid; other site
1218933010711	ABC transporter signature motif; other site
1218933010712	Walker B; other site
1218933010713	D-loop; other site
1218933010714	H-loop/switch region; other site
1218933010715	Protein of unknown function (DUF3561); Region: DUF3561; pfam12084
1218933010716	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1218933010717	ligand-binding site [chemical binding]; other site
1218933010718	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
1218933010719	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1218933010720	CysD dimerization site [polypeptide binding]; other site
1218933010721	G1 box; other site
1218933010722	putative GEF interaction site [polypeptide binding]; other site
1218933010723	GTP/Mg2+ binding site [chemical binding]; other site
1218933010724	Switch I region; other site
1218933010725	G2 box; other site
1218933010726	G3 box; other site
1218933010727	Switch II region; other site
1218933010728	G4 box; other site
1218933010729	G5 box; other site
1218933010730	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1218933010731	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1218933010732	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1218933010733	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1218933010734	Active Sites [active]
1218933010735	siroheme synthase; Provisional; Region: cysG; PRK10637
1218933010736	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1218933010737	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
1218933010738	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1218933010739	active site
1218933010740	SAM binding site [chemical binding]; other site
1218933010741	homodimer interface [polypeptide binding]; other site
1218933010742	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1218933010743	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1218933010744	active site
1218933010745	catalytic site [active]
1218933010746	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1218933010747	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933010748	dimer interface [polypeptide binding]; other site
1218933010749	conserved gate region; other site
1218933010750	ABC-ATPase subunit interface; other site
1218933010751	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1218933010752	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933010753	dimer interface [polypeptide binding]; other site
1218933010754	conserved gate region; other site
1218933010755	putative PBP binding loops; other site
1218933010756	ABC-ATPase subunit interface; other site
1218933010757	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1218933010758	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933010759	Walker A/P-loop; other site
1218933010760	ATP binding site [chemical binding]; other site
1218933010761	Q-loop/lid; other site
1218933010762	ABC transporter signature motif; other site
1218933010763	Walker B; other site
1218933010764	D-loop; other site
1218933010765	H-loop/switch region; other site
1218933010766	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1218933010767	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1218933010768	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933010769	Walker A/P-loop; other site
1218933010770	ATP binding site [chemical binding]; other site
1218933010771	Q-loop/lid; other site
1218933010772	ABC transporter signature motif; other site
1218933010773	Walker B; other site
1218933010774	D-loop; other site
1218933010775	H-loop/switch region; other site
1218933010776	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1218933010777	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1218933010778	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515
1218933010779	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1218933010780	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1218933010781	Active Sites [active]
1218933010782	sulfite reductase subunit beta; Provisional; Region: PRK13504
1218933010783	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1218933010784	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1218933010785	sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953
1218933010786	Flavodoxin; Region: Flavodoxin_1; pfam00258
1218933010787	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
1218933010788	FAD binding pocket [chemical binding]; other site
1218933010789	FAD binding motif [chemical binding]; other site
1218933010790	catalytic residues [active]
1218933010791	NAD binding pocket [chemical binding]; other site
1218933010792	phosphate binding motif [ion binding]; other site
1218933010793	beta-alpha-beta structure motif; other site
1218933010794	PilZ domain; Region: PilZ; pfam07238
1218933010795	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1218933010796	Zn2+ binding site [ion binding]; other site
1218933010797	Mg2+ binding site [ion binding]; other site
1218933010798	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1218933010799	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
1218933010800	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1218933010801	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1218933010802	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
1218933010803	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1218933010804	active site
1218933010805	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
1218933010806	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
1218933010807	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1218933010808	putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730
1218933010809	classical (c) SDRs; Region: SDR_c; cd05233
1218933010810	NAD(P) binding site [chemical binding]; other site
1218933010811	active site
1218933010812	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1218933010813	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1218933010814	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1218933010815	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933010816	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933010817	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1218933010818	dimerization interface [polypeptide binding]; other site
1218933010819	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1218933010820	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
1218933010821	NAD(P) binding site [chemical binding]; other site
1218933010822	catalytic residues [active]
1218933010823	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1218933010824	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
1218933010825	potential catalytic triad [active]
1218933010826	conserved cys residue [active]
1218933010827	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1218933010828	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
1218933010829	putative ligand binding residues [chemical binding]; other site
1218933010830	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1218933010831	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933010832	N-terminal plug; other site
1218933010833	ligand-binding site [chemical binding]; other site
1218933010834	enolase; Provisional; Region: eno; PRK00077
1218933010835	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1218933010836	dimer interface [polypeptide binding]; other site
1218933010837	metal binding site [ion binding]; metal-binding site
1218933010838	substrate binding pocket [chemical binding]; other site
1218933010839	CTP synthetase; Validated; Region: pyrG; PRK05380
1218933010840	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1218933010841	Catalytic site [active]
1218933010842	active site
1218933010843	UTP binding site [chemical binding]; other site
1218933010844	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1218933010845	active site
1218933010846	putative oxyanion hole; other site
1218933010847	catalytic triad [active]
1218933010848	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
1218933010849	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1218933010850	homodimer interface [polypeptide binding]; other site
1218933010851	metal binding site [ion binding]; metal-binding site
1218933010852	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1218933010853	homodimer interface [polypeptide binding]; other site
1218933010854	active site
1218933010855	putative chemical substrate binding site [chemical binding]; other site
1218933010856	metal binding site [ion binding]; metal-binding site
1218933010857	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
1218933010858	HD domain; Region: HD_4; pfam13328
1218933010859	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1218933010860	synthetase active site [active]
1218933010861	NTP binding site [chemical binding]; other site
1218933010862	metal binding site [ion binding]; metal-binding site
1218933010863	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1218933010864	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1218933010865	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
1218933010866	TRAM domain; Region: TRAM; pfam01938
1218933010867	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1218933010868	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933010869	S-adenosylmethionine binding site [chemical binding]; other site
1218933010870	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
1218933010871	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
1218933010872	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933010873	dimerization interface [polypeptide binding]; other site
1218933010874	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1218933010875	dimer interface [polypeptide binding]; other site
1218933010876	phosphorylation site [posttranslational modification]
1218933010877	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933010878	ATP binding site [chemical binding]; other site
1218933010879	Mg2+ binding site [ion binding]; other site
1218933010880	G-X-G motif; other site
1218933010881	Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999
1218933010882	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933010883	active site
1218933010884	phosphorylation site [posttranslational modification]
1218933010885	intermolecular recognition site; other site
1218933010886	dimerization interface [polypeptide binding]; other site
1218933010887	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1218933010888	putative binding surface; other site
1218933010889	active site
1218933010890	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1218933010891	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
1218933010892	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1218933010893	alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558
1218933010894	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
1218933010895	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
1218933010896	active site
1218933010897	tetramer interface [polypeptide binding]; other site
1218933010898	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
1218933010899	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
1218933010900	active site
1218933010901	tetramer interface [polypeptide binding]; other site
1218933010902	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933010903	D-galactonate transporter; Region: 2A0114; TIGR00893
1218933010904	putative substrate translocation pore; other site
1218933010905	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1218933010906	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1218933010907	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1218933010908	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1218933010909	PAS domain; Region: PAS_9; pfam13426
1218933010910	putative active site [active]
1218933010911	heme pocket [chemical binding]; other site
1218933010912	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933010913	dimerization interface [polypeptide binding]; other site
1218933010914	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1218933010915	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933010916	dimer interface [polypeptide binding]; other site
1218933010917	putative CheW interface [polypeptide binding]; other site
1218933010918	SlyX; Region: SlyX; cl01090
1218933010919	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
1218933010920	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1218933010921	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1218933010922	nucleotide binding pocket [chemical binding]; other site
1218933010923	K-X-D-G motif; other site
1218933010924	catalytic site [active]
1218933010925	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1218933010926	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1218933010927	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1218933010928	Dimer interface [polypeptide binding]; other site
1218933010929	BRCT sequence motif; other site
1218933010930	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
1218933010931	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
1218933010932	putative ribose interaction site [chemical binding]; other site
1218933010933	putative ADP binding site [chemical binding]; other site
1218933010934	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
1218933010935	active site
1218933010936	HIGH motif; other site
1218933010937	nucleotide binding site [chemical binding]; other site
1218933010938	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
1218933010939	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1218933010940	metal binding triad; other site
1218933010941	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1218933010942	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1218933010943	metal binding triad; other site
1218933010944	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1218933010945	Uncharacterized conserved protein [Function unknown]; Region: COG3025
1218933010946	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
1218933010947	putative active site [active]
1218933010948	putative metal binding residues [ion binding]; other site
1218933010949	signature motif; other site
1218933010950	putative triphosphate binding site [ion binding]; other site
1218933010951	SH3 domain-containing protein; Provisional; Region: PRK10884
1218933010952	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1218933010953	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
1218933010954	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1218933010955	active site
1218933010956	NTP binding site [chemical binding]; other site
1218933010957	metal binding triad [ion binding]; metal-binding site
1218933010958	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1218933010959	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1218933010960	Zn2+ binding site [ion binding]; other site
1218933010961	Mg2+ binding site [ion binding]; other site
1218933010962	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1218933010963	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
1218933010964	Restriction endonuclease XhoI; Region: XhoI; pfam04555
1218933010965	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1218933010966	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1218933010967	homooctamer interface [polypeptide binding]; other site
1218933010968	active site
1218933010969	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1218933010970	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
1218933010971	dimer interface [polypeptide binding]; other site
1218933010972	ligand binding site [chemical binding]; other site
1218933010973	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933010974	dimerization interface [polypeptide binding]; other site
1218933010975	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933010976	dimer interface [polypeptide binding]; other site
1218933010977	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1218933010978	putative CheW interface [polypeptide binding]; other site
1218933010979	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1218933010980	dimer interface [polypeptide binding]; other site
1218933010981	substrate binding site [chemical binding]; other site
1218933010982	metal binding sites [ion binding]; metal-binding site
1218933010983	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1218933010984	dimerization interface [polypeptide binding]; other site
1218933010985	putative active site pocket [active]
1218933010986	putative catalytic residue [active]
1218933010987	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
1218933010988	Family of unknown function (DUF490); Region: DUF490; pfam04357
1218933010989	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
1218933010990	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1218933010991	Surface antigen; Region: Bac_surface_Ag; pfam01103
1218933010992	methionine sulfoxide reductase A; Provisional; Region: PRK00058
1218933010993	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1218933010994	Domain of unknown function DUF21; Region: DUF21; pfam01595
1218933010995	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1218933010996	Transporter associated domain; Region: CorC_HlyC; smart01091
1218933010997	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
1218933010998	Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695
1218933010999	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1218933011000	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1218933011001	active site
1218933011002	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
1218933011003	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1218933011004	active site
1218933011005	metal binding site [ion binding]; metal-binding site
1218933011006	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1218933011007	Predicted transcriptional regulators [Transcription]; Region: COG1733
1218933011008	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1218933011009	dimerization interface [polypeptide binding]; other site
1218933011010	putative DNA binding site [nucleotide binding]; other site
1218933011011	putative Zn2+ binding site [ion binding]; other site
1218933011012	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1218933011013	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1218933011014	Protein of unknown function (DUF2502); Region: DUF2502; pfam10697
1218933011015	indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393
1218933011016	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
1218933011017	dimer interface [polypeptide binding]; other site
1218933011018	PYR/PP interface [polypeptide binding]; other site
1218933011019	TPP binding site [chemical binding]; other site
1218933011020	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1218933011021	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
1218933011022	TPP-binding site [chemical binding]; other site
1218933011023	dimer interface [polypeptide binding]; other site
1218933011024	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
1218933011025	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
1218933011026	Hemerythrin-like domain; Region: Hr-like; cd12108
1218933011027	Fe binding site [ion binding]; other site
1218933011028	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
1218933011029	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1218933011030	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1218933011031	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
1218933011032	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
1218933011033	Protein of unknown function, DUF488; Region: DUF488; cl01246
1218933011034	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1218933011035	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1218933011036	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1218933011037	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1218933011038	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1218933011039	esterase; Provisional; Region: PRK10566
1218933011040	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1218933011041	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933011042	dimerization interface [polypeptide binding]; other site
1218933011043	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1218933011044	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933011045	dimer interface [polypeptide binding]; other site
1218933011046	putative CheW interface [polypeptide binding]; other site
1218933011047	hypothetical protein; Reviewed; Region: PRK09588
1218933011048	release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073
1218933011049	peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179
1218933011050	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1218933011051	putative biofilm stress and motility protein A; Provisional; Region: PRK14864
1218933011052	Predicted membrane protein [Function unknown]; Region: COG3766
1218933011053	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1218933011054	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1218933011055	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1218933011056	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933011057	dimerization interface [polypeptide binding]; other site
1218933011058	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1218933011059	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933011060	dimer interface [polypeptide binding]; other site
1218933011061	putative CheW interface [polypeptide binding]; other site
1218933011062	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
1218933011063	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1218933011064	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1218933011065	exoribonuclease R; Provisional; Region: PRK11642
1218933011066	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
1218933011067	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1218933011068	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1218933011069	RNB domain; Region: RNB; pfam00773
1218933011070	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1218933011071	RNA binding site [nucleotide binding]; other site
1218933011072	transcriptional repressor NsrR; Provisional; Region: PRK11014
1218933011073	Rrf2 family protein; Region: rrf2_super; TIGR00738
1218933011074	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
1218933011075	dimer interface [polypeptide binding]; other site
1218933011076	ligand binding site [chemical binding]; other site
1218933011077	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933011078	dimerization interface [polypeptide binding]; other site
1218933011079	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1218933011080	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933011081	dimer interface [polypeptide binding]; other site
1218933011082	putative CheW interface [polypeptide binding]; other site
1218933011083	PAS domain S-box; Region: sensory_box; TIGR00229
1218933011084	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1218933011085	putative active site [active]
1218933011086	heme pocket [chemical binding]; other site
1218933011087	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1218933011088	PAS domain; Region: PAS_9; pfam13426
1218933011089	putative active site [active]
1218933011090	heme pocket [chemical binding]; other site
1218933011091	GAF domain; Region: GAF_2; pfam13185
1218933011092	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1218933011093	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1218933011094	metal binding site [ion binding]; metal-binding site
1218933011095	active site
1218933011096	I-site; other site
1218933011097	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
1218933011098	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
1218933011099	Walker A motif; other site
1218933011100	ATP binding site [chemical binding]; other site
1218933011101	Walker B motif; other site
1218933011102	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
1218933011103	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1218933011104	catalytic residue [active]
1218933011105	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1218933011106	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1218933011107	YGGT family; Region: YGGT; pfam02325
1218933011108	Predicted integral membrane protein [Function unknown]; Region: COG0762
1218933011109	hypothetical protein; Validated; Region: PRK05090
1218933011110	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1218933011111	active site
1218933011112	dimerization interface [polypeptide binding]; other site
1218933011113	HemN family oxidoreductase; Provisional; Region: PRK05660
1218933011114	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1218933011115	FeS/SAM binding site; other site
1218933011116	HemN C-terminal domain; Region: HemN_C; pfam06969
1218933011117	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
1218933011118	ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857
1218933011119	entericidin A; Provisional; Region: PRK09810
1218933011120	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933011121	Coenzyme A binding pocket [chemical binding]; other site
1218933011122	lysophospholipid transporter LplT; Provisional; Region: PRK11195
1218933011123	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933011124	putative substrate translocation pore; other site
1218933011125	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
1218933011126	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1218933011127	putative acyl-acceptor binding pocket; other site
1218933011128	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
1218933011129	acyl-activating enzyme (AAE) consensus motif; other site
1218933011130	putative AMP binding site [chemical binding]; other site
1218933011131	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933011132	Coenzyme A binding pocket [chemical binding]; other site
1218933011133	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
1218933011134	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933011135	DNA-binding site [nucleotide binding]; DNA binding site
1218933011136	FCD domain; Region: FCD; pfam07729
1218933011137	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1218933011138	active site
1218933011139	P-loop; other site
1218933011140	phosphorylation site [posttranslational modification]
1218933011141	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1218933011142	beta-galactosidase; Region: BGL; TIGR03356
1218933011143	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1218933011144	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1218933011145	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1218933011146	methionine cluster; other site
1218933011147	active site
1218933011148	phosphorylation site [posttranslational modification]
1218933011149	metal binding site [ion binding]; metal-binding site
1218933011150	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1218933011151	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1218933011152	DNA binding site [nucleotide binding]
1218933011153	domain linker motif; other site
1218933011154	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
1218933011155	dimerization interface (closed form) [polypeptide binding]; other site
1218933011156	ligand binding site [chemical binding]; other site
1218933011157	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1218933011158	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1218933011159	non-specific DNA binding site [nucleotide binding]; other site
1218933011160	salt bridge; other site
1218933011161	sequence-specific DNA binding site [nucleotide binding]; other site
1218933011162	Cupin domain; Region: Cupin_2; cl17218
1218933011163	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1218933011164	EamA-like transporter family; Region: EamA; pfam00892
1218933011165	diaminopimelate decarboxylase; Provisional; Region: PRK11165
1218933011166	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1218933011167	active site
1218933011168	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1218933011169	substrate binding site [chemical binding]; other site
1218933011170	catalytic residues [active]
1218933011171	dimer interface [polypeptide binding]; other site
1218933011172	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
1218933011173	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933011174	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1218933011175	dimerization interface [polypeptide binding]; other site
1218933011176	transcriptional activator TtdR; Provisional; Region: PRK09801
1218933011177	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933011178	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1218933011179	putative effector binding pocket; other site
1218933011180	dimerization interface [polypeptide binding]; other site
1218933011181	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1218933011182	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
1218933011183	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
1218933011184	catalytic residues [active]
1218933011185	Transposase; Region: HTH_Tnp_1; pfam01527
1218933011186	HTH-like domain; Region: HTH_21; pfam13276
1218933011187	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
1218933011188	Integrase core domain; Region: rve; pfam00665
1218933011189	Integrase core domain; Region: rve_3; pfam13683
1218933011190	hypothetical protein; Provisional; Region: PRK10236
1218933011191	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
1218933011192	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1218933011193	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
1218933011194	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1218933011195	FMN binding site [chemical binding]; other site
1218933011196	active site
1218933011197	catalytic residues [active]
1218933011198	substrate binding site [chemical binding]; other site
1218933011199	phage shock protein G; Reviewed; Region: pspG; PRK09459
1218933011200	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1218933011201	Cytochrome P450; Region: p450; cl12078
1218933011202	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
1218933011203	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1218933011204	NADP binding site [chemical binding]; other site
1218933011205	dimer interface [polypeptide binding]; other site
1218933011206	replicative DNA helicase; Provisional; Region: PRK08006
1218933011207	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1218933011208	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1218933011209	Walker A motif; other site
1218933011210	ATP binding site [chemical binding]; other site
1218933011211	Walker B motif; other site
1218933011212	DNA binding loops [nucleotide binding]
1218933011213	alanine racemase; Reviewed; Region: alr; PRK00053
1218933011214	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
1218933011215	active site
1218933011216	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1218933011217	substrate binding site [chemical binding]; other site
1218933011218	catalytic residues [active]
1218933011219	dimer interface [polypeptide binding]; other site
1218933011220	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1218933011221	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1218933011222	AsnC family; Region: AsnC_trans_reg; pfam01037
1218933011223	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1218933011224	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1218933011225	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
1218933011226	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1218933011227	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933011228	homodimer interface [polypeptide binding]; other site
1218933011229	catalytic residue [active]
1218933011230	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
1218933011231	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
1218933011232	Protein of unknown function (DUF1240); Region: DUF1240; pfam06836
1218933011233	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718
1218933011234	CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673
1218933011235	CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562
1218933011236	CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735
1218933011237	CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09676
1218933011238	CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737
1218933011239	CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739
1218933011240	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
1218933011241	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1218933011242	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1218933011243	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1218933011244	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1218933011245	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1218933011246	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1218933011247	dimer interface [polypeptide binding]; other site
1218933011248	ssDNA binding site [nucleotide binding]; other site
1218933011249	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1218933011250	putative single-stranded DNA-binding protein; Region: PHA01740
1218933011251	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1218933011252	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1218933011253	active site
1218933011254	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1218933011255	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933011256	Coenzyme A binding pocket [chemical binding]; other site
1218933011257	OPT oligopeptide transporter protein; Region: OPT; cl14607
1218933011258	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1218933011259	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1218933011260	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1218933011261	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933011262	DNA-binding site [nucleotide binding]; DNA binding site
1218933011263	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1218933011264	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933011265	homodimer interface [polypeptide binding]; other site
1218933011266	catalytic residue [active]
1218933011267	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1218933011268	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1218933011269	DNA binding site [nucleotide binding]
1218933011270	domain linker motif; other site
1218933011271	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1218933011272	ligand binding site [chemical binding]; other site
1218933011273	dimerization interface [polypeptide binding]; other site
1218933011274	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1218933011275	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933011276	dimer interface [polypeptide binding]; other site
1218933011277	conserved gate region; other site
1218933011278	putative PBP binding loops; other site
1218933011279	ABC-ATPase subunit interface; other site
1218933011280	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1218933011281	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933011282	ABC-ATPase subunit interface; other site
1218933011283	putative PBP binding loops; other site
1218933011284	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1218933011285	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1218933011286	Walker A/P-loop; other site
1218933011287	ATP binding site [chemical binding]; other site
1218933011288	Q-loop/lid; other site
1218933011289	ABC transporter signature motif; other site
1218933011290	Walker B; other site
1218933011291	D-loop; other site
1218933011292	H-loop/switch region; other site
1218933011293	TOBE domain; Region: TOBE_2; pfam08402
1218933011294	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1218933011295	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1218933011296	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1218933011297	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1218933011298	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
1218933011299	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
1218933011300	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1218933011301	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1218933011302	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1218933011303	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1218933011304	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1218933011305	ABC-ATPase subunit  interface; other site
1218933011306	dimer interface [polypeptide binding]; other site
1218933011307	putative PBP binding regions; other site
1218933011308	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1218933011309	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1218933011310	metal binding site [ion binding]; metal-binding site
1218933011311	Lipocalin-like domain; Region: Lipocalin_5; pfam13924
1218933011312	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1218933011313	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1218933011314	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1218933011315	4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371
1218933011316	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1218933011317	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1218933011318	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1218933011319	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
1218933011320	putative active site [active]
1218933011321	metal binding site [ion binding]; metal-binding site
1218933011322	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1218933011323	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1218933011324	inhibitor site; inhibition site
1218933011325	active site
1218933011326	dimer interface [polypeptide binding]; other site
1218933011327	catalytic residue [active]
1218933011328	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
1218933011329	Na binding site [ion binding]; other site
1218933011330	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
1218933011331	BNR repeat-like domain; Region: BNR_2; pfam13088
1218933011332	Domain of unknown function (DUF386); Region: DUF386; cl01047
1218933011333	short chain dehydrogenase; Provisional; Region: PRK07577
1218933011334	classical (c) SDRs; Region: SDR_c; cd05233
1218933011335	NAD(P) binding site [chemical binding]; other site
1218933011336	active site
1218933011337	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1218933011338	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1218933011339	DNA binding site [nucleotide binding]
1218933011340	domain linker motif; other site
1218933011341	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1218933011342	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1218933011343	DNA binding site [nucleotide binding]
1218933011344	domain linker motif; other site
1218933011345	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1218933011346	putative ligand binding site [chemical binding]; other site
1218933011347	putative dimerization interface [polypeptide binding]; other site
1218933011348	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1218933011349	active site
1218933011350	phosphorylation site [posttranslational modification]
1218933011351	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1218933011352	active site
1218933011353	P-loop; other site
1218933011354	phosphorylation site [posttranslational modification]
1218933011355	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
1218933011356	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1218933011357	active site
1218933011358	intersubunit interactions; other site
1218933011359	catalytic residue [active]
1218933011360	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1218933011361	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1218933011362	substrate binding pocket [chemical binding]; other site
1218933011363	membrane-bound complex binding site; other site
1218933011364	hinge residues; other site
1218933011365	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1218933011366	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933011367	dimer interface [polypeptide binding]; other site
1218933011368	conserved gate region; other site
1218933011369	putative PBP binding loops; other site
1218933011370	ABC-ATPase subunit interface; other site
1218933011371	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1218933011372	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933011373	Walker A/P-loop; other site
1218933011374	ATP binding site [chemical binding]; other site
1218933011375	Q-loop/lid; other site
1218933011376	ABC transporter signature motif; other site
1218933011377	Walker B; other site
1218933011378	D-loop; other site
1218933011379	H-loop/switch region; other site
1218933011380	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933011381	dimer interface [polypeptide binding]; other site
1218933011382	conserved gate region; other site
1218933011383	putative PBP binding loops; other site
1218933011384	ABC-ATPase subunit interface; other site
1218933011385	hypothetical protein; Provisional; Region: PRK05248
1218933011386	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
1218933011387	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
1218933011388	substrate binding site [chemical binding]; other site
1218933011389	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
1218933011390	substrate binding site [chemical binding]; other site
1218933011391	ligand binding site [chemical binding]; other site
1218933011392	Protein of unknown function (DUF3060); Region: DUF3060; pfam11259
1218933011393	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1218933011394	dimerization interface [polypeptide binding]; other site
1218933011395	putative DNA binding site [nucleotide binding]; other site
1218933011396	putative Zn2+ binding site [ion binding]; other site
1218933011397	outer membrane receptor FepA; Provisional; Region: PRK13524
1218933011398	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933011399	N-terminal plug; other site
1218933011400	ligand-binding site [chemical binding]; other site
1218933011401	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933011402	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1218933011403	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
1218933011404	Abhydrolase family; Region: Abhydrolase_7; pfam12715
1218933011405	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1218933011406	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1218933011407	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933011408	putative substrate translocation pore; other site
1218933011409	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1218933011410	Beta-lactamase; Region: Beta-lactamase; pfam00144
1218933011411	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933011412	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933011413	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
1218933011414	putative dimerization interface [polypeptide binding]; other site
1218933011415	putative effector binding pocket; other site
1218933011416	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
1218933011417	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1218933011418	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1218933011419	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1218933011420	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
1218933011421	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1218933011422	E3 interaction surface; other site
1218933011423	lipoyl attachment site [posttranslational modification]; other site
1218933011424	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1218933011425	E3 interaction surface; other site
1218933011426	lipoyl attachment site [posttranslational modification]; other site
1218933011427	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1218933011428	E3 interaction surface; other site
1218933011429	lipoyl attachment site [posttranslational modification]; other site
1218933011430	e3 binding domain; Region: E3_binding; pfam02817
1218933011431	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1218933011432	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1218933011433	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1218933011434	dimer interface [polypeptide binding]; other site
1218933011435	TPP-binding site [chemical binding]; other site
1218933011436	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
1218933011437	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933011438	DNA-binding site [nucleotide binding]; DNA binding site
1218933011439	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1218933011440	aromatic amino acid transporter; Provisional; Region: PRK10238
1218933011441	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1218933011442	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933011443	putative substrate translocation pore; other site
1218933011444	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
1218933011445	active site
1218933011446	regulatory protein AmpE; Provisional; Region: PRK10987
1218933011447	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1218933011448	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1218933011449	amidase catalytic site [active]
1218933011450	Zn binding residues [ion binding]; other site
1218933011451	substrate binding site [chemical binding]; other site
1218933011452	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
1218933011453	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
1218933011454	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1218933011455	dimerization interface [polypeptide binding]; other site
1218933011456	active site
1218933011457	putative major pilin subunit; Provisional; Region: PRK10574
1218933011458	Pilin (bacterial filament); Region: Pilin; pfam00114
1218933011459	hypothetical protein; Provisional; Region: PRK10436
1218933011460	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1218933011461	Walker A motif; other site
1218933011462	ATP binding site [chemical binding]; other site
1218933011463	Walker B motif; other site
1218933011464	type IV pilin biogenesis protein; Provisional; Region: PRK10573
1218933011465	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1218933011466	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1218933011467	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
1218933011468	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1218933011469	active site
1218933011470	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1218933011471	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1218933011472	CoA-binding site [chemical binding]; other site
1218933011473	ATP-binding [chemical binding]; other site
1218933011474	hypothetical protein; Provisional; Region: PRK05287
1218933011475	DNA gyrase inhibitor; Reviewed; Region: PRK00418
1218933011476	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1218933011477	active site
1218933011478	8-oxo-dGMP binding site [chemical binding]; other site
1218933011479	nudix motif; other site
1218933011480	metal binding site [ion binding]; metal-binding site
1218933011481	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1218933011482	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1218933011483	SEC-C motif; Region: SEC-C; pfam02810
1218933011484	SecA regulator SecM; Provisional; Region: PRK02943
1218933011485	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4701
1218933011486	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
1218933011487	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
1218933011488	cell division protein FtsZ; Validated; Region: PRK09330
1218933011489	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1218933011490	nucleotide binding site [chemical binding]; other site
1218933011491	SulA interaction site; other site
1218933011492	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
1218933011493	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1218933011494	Cell division protein FtsA; Region: FtsA; pfam14450
1218933011495	cell division protein FtsQ; Provisional; Region: PRK10775
1218933011496	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1218933011497	Cell division protein FtsQ; Region: FtsQ; pfam03799
1218933011498	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
1218933011499	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1218933011500	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1218933011501	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1218933011502	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1218933011503	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1218933011504	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1218933011505	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1218933011506	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1218933011507	active site
1218933011508	homodimer interface [polypeptide binding]; other site
1218933011509	cell division protein FtsW; Provisional; Region: PRK10774
1218933011510	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
1218933011511	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1218933011512	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1218933011513	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1218933011514	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1218933011515	Mg++ binding site [ion binding]; other site
1218933011516	putative catalytic motif [active]
1218933011517	putative substrate binding site [chemical binding]; other site
1218933011518	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
1218933011519	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1218933011520	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1218933011521	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1218933011522	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1218933011523	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1218933011524	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1218933011525	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1218933011526	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
1218933011527	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1218933011528	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1218933011529	cell division protein FtsL; Provisional; Region: PRK10772
1218933011530	16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006
1218933011531	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1218933011532	cell division protein MraZ; Reviewed; Region: PRK00326
1218933011533	MraZ protein; Region: MraZ; pfam02381
1218933011534	MraZ protein; Region: MraZ; pfam02381
1218933011535	Protein of unknown function (DUF1144); Region: DUF1144; pfam06610
1218933011536	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
1218933011537	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1218933011538	DNA binding site [nucleotide binding]
1218933011539	domain linker motif; other site
1218933011540	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
1218933011541	dimerization interface [polypeptide binding]; other site
1218933011542	ligand binding site [chemical binding]; other site
1218933011543	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1218933011544	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1218933011545	putative valine binding site [chemical binding]; other site
1218933011546	dimer interface [polypeptide binding]; other site
1218933011547	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1218933011548	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979
1218933011549	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1218933011550	PYR/PP interface [polypeptide binding]; other site
1218933011551	dimer interface [polypeptide binding]; other site
1218933011552	TPP binding site [chemical binding]; other site
1218933011553	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1218933011554	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1218933011555	TPP-binding site [chemical binding]; other site
1218933011556	dimer interface [polypeptide binding]; other site
1218933011557	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1218933011558	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1218933011559	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1218933011560	acyl-activating enzyme (AAE) consensus motif; other site
1218933011561	putative AMP binding site [chemical binding]; other site
1218933011562	putative active site [active]
1218933011563	putative CoA binding site [chemical binding]; other site
1218933011564	2-isopropylmalate synthase; Validated; Region: PRK00915
1218933011565	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1218933011566	active site
1218933011567	catalytic residues [active]
1218933011568	metal binding site [ion binding]; metal-binding site
1218933011569	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
1218933011570	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1218933011571	tartrate dehydrogenase; Region: TTC; TIGR02089
1218933011572	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1218933011573	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1218933011574	substrate binding site [chemical binding]; other site
1218933011575	ligand binding site [chemical binding]; other site
1218933011576	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1218933011577	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1218933011578	substrate binding site [chemical binding]; other site
1218933011579	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
1218933011580	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1218933011581	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1218933011582	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1218933011583	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933011584	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
1218933011585	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
1218933011586	dimer interface [polypeptide binding]; other site
1218933011587	ligand binding site [chemical binding]; other site
1218933011588	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933011589	dimerization interface [polypeptide binding]; other site
1218933011590	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933011591	dimer interface [polypeptide binding]; other site
1218933011592	putative CheW interface [polypeptide binding]; other site
1218933011593	tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238
1218933011594	Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617
1218933011595	substrate binding site [chemical binding]; other site
1218933011596	tetramer interface [polypeptide binding]; other site
1218933011597	catalytic residue [active]
1218933011598	transcriptional regulator SgrR; Provisional; Region: PRK13626
1218933011599	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
1218933011600	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
1218933011601	phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259
1218933011602	NmrA-like family; Region: NmrA; pfam05368
1218933011603	NAD(P) binding site [chemical binding]; other site
1218933011604	active site lysine
1218933011605	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933011606	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933011607	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1218933011608	putative effector binding pocket; other site
1218933011609	putative dimerization interface [polypeptide binding]; other site
1218933011610	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
1218933011611	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
1218933011612	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
1218933011613	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933011614	dimer interface [polypeptide binding]; other site
1218933011615	conserved gate region; other site
1218933011616	putative PBP binding loops; other site
1218933011617	ABC-ATPase subunit interface; other site
1218933011618	thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771
1218933011619	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933011620	Walker A/P-loop; other site
1218933011621	ATP binding site [chemical binding]; other site
1218933011622	Q-loop/lid; other site
1218933011623	ABC transporter signature motif; other site
1218933011624	Walker B; other site
1218933011625	D-loop; other site
1218933011626	H-loop/switch region; other site
1218933011627	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1218933011628	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_3; cd09002
1218933011629	active site
1218933011630	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
1218933011631	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1218933011632	PYR/PP interface [polypeptide binding]; other site
1218933011633	dimer interface [polypeptide binding]; other site
1218933011634	TPP binding site [chemical binding]; other site
1218933011635	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1218933011636	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1218933011637	TPP-binding site [chemical binding]; other site
1218933011638	dimer interface [polypeptide binding]; other site
1218933011639	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
1218933011640	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1218933011641	putative valine binding site [chemical binding]; other site
1218933011642	dimer interface [polypeptide binding]; other site
1218933011643	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1218933011644	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1218933011645	Cache domain; Region: Cache_1; pfam02743
1218933011646	DNA polymerase II; Reviewed; Region: PRK05762
1218933011647	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
1218933011648	active site
1218933011649	catalytic site [active]
1218933011650	substrate binding site [chemical binding]; other site
1218933011651	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
1218933011652	active site
1218933011653	metal-binding site
1218933011654	ATP-dependent helicase HepA; Validated; Region: PRK04914
1218933011655	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1218933011656	ATP binding site [chemical binding]; other site
1218933011657	putative Mg++ binding site [ion binding]; other site
1218933011658	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1218933011659	nucleotide binding region [chemical binding]; other site
1218933011660	ATP-binding site [chemical binding]; other site
1218933011661	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1218933011662	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1218933011663	active site
1218933011664	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
1218933011665	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
1218933011666	putative metal binding site [ion binding]; other site
1218933011667	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1218933011668	HSP70 interaction site [polypeptide binding]; other site
1218933011669	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
1218933011670	OstA-like protein; Region: OstA; pfam03968
1218933011671	Organic solvent tolerance protein; Region: OstA_C; pfam04453
1218933011672	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
1218933011673	SurA N-terminal domain; Region: SurA_N; pfam09312
1218933011674	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1218933011675	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1218933011676	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
1218933011677	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1218933011678	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1218933011679	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
1218933011680	S-adenosylmethionine binding site [chemical binding]; other site
1218933011681	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
1218933011682	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
1218933011683	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
1218933011684	active site
1218933011685	metal binding site [ion binding]; metal-binding site
1218933011686	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1218933011687	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933011688	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933011689	The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465
1218933011690	putative substrate binding pocket [chemical binding]; other site
1218933011691	putative dimerization interface [polypeptide binding]; other site
1218933011692	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1218933011693	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1218933011694	folate binding site [chemical binding]; other site
1218933011695	NADP+ binding site [chemical binding]; other site
1218933011696	hypothetical protein; Provisional; Region: PRK09917
1218933011697	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1218933011698	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1218933011699	LysE type translocator; Region: LysE; cl00565
1218933011700	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1218933011701	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1218933011702	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1218933011703	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1218933011704	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1218933011705	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1218933011706	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1218933011707	IMP binding site; other site
1218933011708	dimer interface [polypeptide binding]; other site
1218933011709	interdomain contacts; other site
1218933011710	partial ornithine binding site; other site
1218933011711	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1218933011712	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1218933011713	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1218933011714	catalytic site [active]
1218933011715	subunit interface [polypeptide binding]; other site
1218933011716	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
1218933011717	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1218933011718	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1218933011719	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1218933011720	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1218933011721	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
1218933011722	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1218933011723	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1218933011724	lipoprotein signal peptidase; Provisional; Region: PRK14787
1218933011725	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1218933011726	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1218933011727	active site
1218933011728	HIGH motif; other site
1218933011729	nucleotide binding site [chemical binding]; other site
1218933011730	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1218933011731	active site
1218933011732	KMSKS motif; other site
1218933011733	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1218933011734	tRNA binding surface [nucleotide binding]; other site
1218933011735	anticodon binding site; other site
1218933011736	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1218933011737	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1218933011738	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1218933011739	active site
1218933011740	Riboflavin kinase; Region: Flavokinase; smart00904
1218933011741	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1218933011742	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
1218933011743	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933011744	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
1218933011745	putative dimerization interface [polypeptide binding]; other site
1218933011746	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
1218933011747	chaperone protein DnaJ; Provisional; Region: PRK10767
1218933011748	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1218933011749	HSP70 interaction site [polypeptide binding]; other site
1218933011750	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1218933011751	substrate binding site [polypeptide binding]; other site
1218933011752	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1218933011753	Zn binding sites [ion binding]; other site
1218933011754	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1218933011755	dimer interface [polypeptide binding]; other site
1218933011756	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1218933011757	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1218933011758	nucleotide binding site [chemical binding]; other site
1218933011759	hypothetical protein; Provisional; Region: PRK10659
1218933011760	metabolite-proton symporter; Region: 2A0106; TIGR00883
1218933011761	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933011762	putative substrate translocation pore; other site
1218933011763	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1218933011764	MPT binding site; other site
1218933011765	trimer interface [polypeptide binding]; other site
1218933011766	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1218933011767	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1218933011768	metal binding site [ion binding]; metal-binding site
1218933011769	active site
1218933011770	I-site; other site
1218933011771	transaldolase-like protein; Provisional; Region: PTZ00411
1218933011772	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
1218933011773	active site
1218933011774	dimer interface [polypeptide binding]; other site
1218933011775	catalytic residue [active]
1218933011776	hypothetical protein; Validated; Region: PRK02101
1218933011777	threonine synthase; Validated; Region: PRK09225
1218933011778	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1218933011779	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1218933011780	catalytic residue [active]
1218933011781	homoserine kinase; Provisional; Region: PRK01212
1218933011782	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1218933011783	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1218933011784	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
1218933011785	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
1218933011786	putative catalytic residues [active]
1218933011787	putative nucleotide binding site [chemical binding]; other site
1218933011788	putative aspartate binding site [chemical binding]; other site
1218933011789	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
1218933011790	dimer interface [polypeptide binding]; other site
1218933011791	putative threonine allosteric regulatory site; other site
1218933011792	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
1218933011793	putative threonine allosteric regulatory site; other site
1218933011794	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1218933011795	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1218933011796	putative RNA methyltransferase; Provisional; Region: PRK10433
1218933011797	RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050
1218933011798	two-component response regulator; Provisional; Region: PRK11173
1218933011799	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933011800	active site
1218933011801	phosphorylation site [posttranslational modification]
1218933011802	intermolecular recognition site; other site
1218933011803	dimerization interface [polypeptide binding]; other site
1218933011804	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1218933011805	DNA binding site [nucleotide binding]
1218933011806	hypothetical protein; Provisional; Region: PRK10756
1218933011807	CreA protein; Region: CreA; pfam05981
1218933011808	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
1218933011809	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933011810	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
1218933011811	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1218933011812	catalytic core [active]
1218933011813	inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074
1218933011814	Trp operon repressor; Provisional; Region: PRK01381
1218933011815	lytic murein transglycosylase; Provisional; Region: PRK11619
1218933011816	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1218933011817	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1218933011818	catalytic residue [active]
1218933011819	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1218933011820	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1218933011821	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1218933011822	ABC transporter; Region: ABC_tran_2; pfam12848
1218933011823	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1218933011824	Tar ligand binding domain homologue; Region: TarH; pfam02203
1218933011825	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
1218933011826	dimer interface [polypeptide binding]; other site
1218933011827	ligand binding site [chemical binding]; other site
1218933011828	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933011829	dimerization interface [polypeptide binding]; other site
1218933011830	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933011831	dimer interface [polypeptide binding]; other site
1218933011832	putative CheW interface [polypeptide binding]; other site
1218933011833	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933011834	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933011835	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1218933011836	putative effector binding pocket; other site
1218933011837	dimerization interface [polypeptide binding]; other site
1218933011838	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1218933011839	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1218933011840	putative NAD(P) binding site [chemical binding]; other site
1218933011841	dimer interface [polypeptide binding]; other site
1218933011842	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
1218933011843	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
1218933011844	ligand binding site [chemical binding]; other site
1218933011845	NAD binding site [chemical binding]; other site
1218933011846	tetramer interface [polypeptide binding]; other site
1218933011847	catalytic site [active]
1218933011848	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
1218933011849	L-serine binding site [chemical binding]; other site
1218933011850	ACT domain interface; other site
1218933011851	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1218933011852	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1218933011853	active site
1218933011854	dimer interface [polypeptide binding]; other site
1218933011855	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
1218933011856	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933011857	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
1218933011858	putative dimerization interface [polypeptide binding]; other site
1218933011859	Uncharacterized conserved protein [Function unknown]; Region: COG2968
1218933011860	oxidative stress defense protein; Provisional; Region: PRK11087
1218933011861	arginine exporter protein; Provisional; Region: PRK09304
1218933011862	mechanosensitive channel MscS; Provisional; Region: PRK10334
1218933011863	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1218933011864	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1218933011865	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
1218933011866	active site
1218933011867	intersubunit interface [polypeptide binding]; other site
1218933011868	zinc binding site [ion binding]; other site
1218933011869	Na+ binding site [ion binding]; other site
1218933011870	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1218933011871	Phosphoglycerate kinase; Region: PGK; pfam00162
1218933011872	substrate binding site [chemical binding]; other site
1218933011873	hinge regions; other site
1218933011874	ADP binding site [chemical binding]; other site
1218933011875	catalytic site [active]
1218933011876	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
1218933011877	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1218933011878	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1218933011879	transketolase; Reviewed; Region: PRK12753
1218933011880	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1218933011881	TPP-binding site [chemical binding]; other site
1218933011882	dimer interface [polypeptide binding]; other site
1218933011883	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1218933011884	PYR/PP interface [polypeptide binding]; other site
1218933011885	dimer interface [polypeptide binding]; other site
1218933011886	TPP binding site [chemical binding]; other site
1218933011887	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1218933011888	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1218933011889	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1218933011890	DNA binding residues [nucleotide binding]
1218933011891	dimerization interface [polypeptide binding]; other site
1218933011892	arginine decarboxylase; Provisional; Region: PRK05354
1218933011893	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
1218933011894	dimer interface [polypeptide binding]; other site
1218933011895	active site
1218933011896	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1218933011897	catalytic residues [active]
1218933011898	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1218933011899	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1218933011900	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1218933011901	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1218933011902	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1218933011903	hypothetical protein; Provisional; Region: PRK04860
1218933011904	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
1218933011905	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
1218933011906	DNA-specific endonuclease I; Provisional; Region: PRK15137
1218933011907	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1218933011908	RNA methyltransferase, RsmE family; Region: TIGR00046
1218933011909	glutathione synthetase; Provisional; Region: PRK05246
1218933011910	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
1218933011911	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
1218933011912	hypothetical protein; Validated; Region: PRK00228
1218933011913	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1218933011914	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
1218933011915	AMP binding site [chemical binding]; other site
1218933011916	metal binding site [ion binding]; metal-binding site
1218933011917	active site
1218933011918	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
1218933011919	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1218933011920	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1218933011921	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1218933011922	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1218933011923	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1218933011924	GDP-binding site [chemical binding]; other site
1218933011925	ACT binding site; other site
1218933011926	IMP binding site; other site
1218933011927	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
1218933011928	FtsH protease regulator HflC; Provisional; Region: PRK11029
1218933011929	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
1218933011930	FtsH protease regulator HflK; Provisional; Region: PRK10930
1218933011931	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
1218933011932	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
1218933011933	GTPase HflX; Provisional; Region: PRK11058
1218933011934	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1218933011935	HflX GTPase family; Region: HflX; cd01878
1218933011936	G1 box; other site
1218933011937	GTP/Mg2+ binding site [chemical binding]; other site
1218933011938	Switch I region; other site
1218933011939	G2 box; other site
1218933011940	G3 box; other site
1218933011941	Switch II region; other site
1218933011942	G4 box; other site
1218933011943	G5 box; other site
1218933011944	bacterial Hfq-like; Region: Hfq; cd01716
1218933011945	hexamer interface [polypeptide binding]; other site
1218933011946	Sm1 motif; other site
1218933011947	RNA binding site [nucleotide binding]; other site
1218933011948	Sm2 motif; other site
1218933011949	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1218933011950	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1218933011951	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1218933011952	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933011953	ATP binding site [chemical binding]; other site
1218933011954	Mg2+ binding site [ion binding]; other site
1218933011955	G-X-G motif; other site
1218933011956	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
1218933011957	ATP binding site [chemical binding]; other site
1218933011958	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1218933011959	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
1218933011960	AMIN domain; Region: AMIN; pfam11741
1218933011961	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1218933011962	active site
1218933011963	metal binding site [ion binding]; metal-binding site
1218933011964	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1218933011965	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1218933011966	ADP-binding protein; Provisional; Region: PRK10646
1218933011967	putative carbohydrate kinase; Provisional; Region: PRK10565
1218933011968	Uncharacterized conserved protein [Function unknown]; Region: COG0062
1218933011969	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1218933011970	putative substrate binding site [chemical binding]; other site
1218933011971	putative ATP binding site [chemical binding]; other site
1218933011972	epoxyqueuosine reductase; Region: TIGR00276
1218933011973	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1218933011974	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
1218933011975	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1218933011976	catalytic residue [active]
1218933011977	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1218933011978	catalytic residues [active]
1218933011979	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1218933011980	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1218933011981	alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382
1218933011982	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1218933011983	dimer interface [polypeptide binding]; other site
1218933011984	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1218933011985	catalytic triad [active]
1218933011986	peroxidatic and resolving cysteines [active]
1218933011987	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
1218933011988	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
1218933011989	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1218933011990	NAD binding site [chemical binding]; other site
1218933011991	ligand binding site [chemical binding]; other site
1218933011992	catalytic site [active]
1218933011993	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1218933011994	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1218933011995	putative NAD(P) binding site [chemical binding]; other site
1218933011996	putative substrate binding site [chemical binding]; other site
1218933011997	catalytic Zn binding site [ion binding]; other site
1218933011998	structural Zn binding site [ion binding]; other site
1218933011999	dimer interface [polypeptide binding]; other site
1218933012000	LysE type translocator; Region: LysE; cl00565
1218933012001	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1218933012002	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933012003	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1218933012004	dimerization interface [polypeptide binding]; other site
1218933012005	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933012006	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1218933012007	putative substrate translocation pore; other site
1218933012008	Protein of unknown function DUF262; Region: DUF262; pfam03235
1218933012009	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1218933012010	Uncharacterized conserved protein [Function unknown]; Region: COG4938
1218933012011	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
1218933012012	Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693
1218933012013	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1218933012014	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1218933012015	non-specific DNA binding site [nucleotide binding]; other site
1218933012016	salt bridge; other site
1218933012017	sequence-specific DNA binding site [nucleotide binding]; other site
1218933012018	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1218933012019	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1218933012020	non-specific DNA binding site [nucleotide binding]; other site
1218933012021	salt bridge; other site
1218933012022	sequence-specific DNA binding site [nucleotide binding]; other site
1218933012023	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
1218933012024	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
1218933012025	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1218933012026	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933012027	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1218933012028	putative DNA binding site [nucleotide binding]; other site
1218933012029	putative Zn2+ binding site [ion binding]; other site
1218933012030	Cupin domain; Region: Cupin_2; cl17218
1218933012031	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1218933012032	catalytic site [active]
1218933012033	putative active site [active]
1218933012034	putative substrate binding site [chemical binding]; other site
1218933012035	dimer interface [polypeptide binding]; other site
1218933012036	GTPase RsgA; Reviewed; Region: PRK12288
1218933012037	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1218933012038	RNA binding site [nucleotide binding]; other site
1218933012039	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1218933012040	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1218933012041	GTP/Mg2+ binding site [chemical binding]; other site
1218933012042	G4 box; other site
1218933012043	G5 box; other site
1218933012044	G1 box; other site
1218933012045	Switch I region; other site
1218933012046	G2 box; other site
1218933012047	G3 box; other site
1218933012048	Switch II region; other site
1218933012049	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
1218933012050	putative mechanosensitive channel protein; Provisional; Region: PRK10929
1218933012051	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
1218933012052	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1218933012053	poxB regulator PoxA; Provisional; Region: PRK09350
1218933012054	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1218933012055	motif 1; other site
1218933012056	dimer interface [polypeptide binding]; other site
1218933012057	active site
1218933012058	motif 2; other site
1218933012059	motif 3; other site
1218933012060	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
1218933012061	L-aspartate oxidase; Provisional; Region: PRK06175
1218933012062	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1218933012063	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
1218933012064	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1218933012065	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
1218933012066	D-subunit interface [polypeptide binding]; other site
1218933012067	Iron-sulfur protein interface; other site
1218933012068	proximal quinone binding site [chemical binding]; other site
1218933012069	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
1218933012070	Iron-sulfur protein interface; other site
1218933012071	proximal quinone binding site [chemical binding]; other site
1218933012072	C-subunit interface; other site
1218933012073	distal quinone binding site; other site
1218933012074	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
1218933012075	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
1218933012076	Protein of unknown function, DUF486; Region: DUF486; cl01236
1218933012077	Predicted small secreted protein [Function unknown]; Region: COG5510
1218933012078	elongation factor P; Validated; Region: PRK00529
1218933012079	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1218933012080	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1218933012081	RNA binding site [nucleotide binding]; other site
1218933012082	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1218933012083	RNA binding site [nucleotide binding]; other site
1218933012084	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
1218933012085	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1218933012086	FeS/SAM binding site; other site
1218933012087	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
1218933012088	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1218933012089	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1218933012090	active site
1218933012091	dimer interface [polypeptide binding]; other site
1218933012092	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1218933012093	dimer interface [polypeptide binding]; other site
1218933012094	active site
1218933012095	aspartate kinase III; Validated; Region: PRK09084
1218933012096	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1218933012097	nucleotide binding site [chemical binding]; other site
1218933012098	substrate binding site [chemical binding]; other site
1218933012099	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1218933012100	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
1218933012101	dimer interface [polypeptide binding]; other site
1218933012102	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1218933012103	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1218933012104	PhoU domain; Region: PhoU; pfam01895
1218933012105	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1218933012106	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1218933012107	transmembrane helices; other site
1218933012108	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
1218933012109	putative active site [active]
1218933012110	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
1218933012111	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933012112	N-terminal plug; other site
1218933012113	ligand-binding site [chemical binding]; other site
1218933012114	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1218933012115	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
1218933012116	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1218933012117	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
1218933012118	substrate binding pocket [chemical binding]; other site
1218933012119	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1218933012120	B12 binding site [chemical binding]; other site
1218933012121	cobalt ligand [ion binding]; other site
1218933012122	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1218933012123	transcriptional repressor IclR; Provisional; Region: PRK11569
1218933012124	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1218933012125	Bacterial transcriptional regulator; Region: IclR; pfam01614
1218933012126	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
1218933012127	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
1218933012128	isocitrate lyase; Provisional; Region: PRK15063
1218933012129	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1218933012130	tetramer interface [polypeptide binding]; other site
1218933012131	active site
1218933012132	Mg2+/Mn2+ binding site [ion binding]; other site
1218933012133	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
1218933012134	malate synthase A; Region: malate_syn_A; TIGR01344
1218933012135	active site
1218933012136	homoserine O-succinyltransferase; Provisional; Region: PRK05368
1218933012137	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
1218933012138	proposed active site lysine [active]
1218933012139	conserved cys residue [active]
1218933012140	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1218933012141	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1218933012142	trimer interface [polypeptide binding]; other site
1218933012143	putative metal binding site [ion binding]; other site
1218933012144	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
1218933012145	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1218933012146	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1218933012147	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1218933012148	shikimate binding site; other site
1218933012149	NAD(P) binding site [chemical binding]; other site
1218933012150	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1218933012151	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1218933012152	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
1218933012153	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1218933012154	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1218933012155	hypothetical protein; Validated; Region: PRK03430
1218933012156	hypothetical protein; Provisional; Region: PRK10736
1218933012157	DNA protecting protein DprA; Region: dprA; TIGR00732
1218933012158	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1218933012159	active site
1218933012160	catalytic residues [active]
1218933012161	metal binding site [ion binding]; metal-binding site
1218933012162	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1218933012163	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1218933012164	putative active site [active]
1218933012165	substrate binding site [chemical binding]; other site
1218933012166	putative cosubstrate binding site; other site
1218933012167	catalytic site [active]
1218933012168	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1218933012169	substrate binding site [chemical binding]; other site
1218933012170	16S rRNA methyltransferase B; Provisional; Region: PRK10901
1218933012171	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
1218933012172	putative RNA binding site [nucleotide binding]; other site
1218933012173	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933012174	S-adenosylmethionine binding site [chemical binding]; other site
1218933012175	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
1218933012176	TrkA-N domain; Region: TrkA_N; pfam02254
1218933012177	TrkA-C domain; Region: TrkA_C; pfam02080
1218933012178	TrkA-N domain; Region: TrkA_N; pfam02254
1218933012179	TrkA-C domain; Region: TrkA_C; pfam02080
1218933012180	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
1218933012181	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1218933012182	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036
1218933012183	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1218933012184	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1218933012185	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1218933012186	alphaNTD homodimer interface [polypeptide binding]; other site
1218933012187	alphaNTD - beta interaction site [polypeptide binding]; other site
1218933012188	alphaNTD - beta' interaction site [polypeptide binding]; other site
1218933012189	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1218933012190	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1218933012191	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1218933012192	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1218933012193	RNA binding surface [nucleotide binding]; other site
1218933012194	30S ribosomal protein S11; Validated; Region: PRK05309
1218933012195	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1218933012196	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1218933012197	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
1218933012198	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1218933012199	SecY translocase; Region: SecY; pfam00344
1218933012200	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1218933012201	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1218933012202	23S rRNA binding site [nucleotide binding]; other site
1218933012203	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1218933012204	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1218933012205	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1218933012206	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1218933012207	5S rRNA interface [nucleotide binding]; other site
1218933012208	23S rRNA interface [nucleotide binding]; other site
1218933012209	L5 interface [polypeptide binding]; other site
1218933012210	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1218933012211	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1218933012212	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1218933012213	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1218933012214	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1218933012215	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1218933012216	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1218933012217	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1218933012218	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1218933012219	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1218933012220	RNA binding site [nucleotide binding]; other site
1218933012221	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1218933012222	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1218933012223	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1218933012224	23S rRNA interface [nucleotide binding]; other site
1218933012225	putative translocon interaction site; other site
1218933012226	signal recognition particle (SRP54) interaction site; other site
1218933012227	L23 interface [polypeptide binding]; other site
1218933012228	trigger factor interaction site; other site
1218933012229	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1218933012230	23S rRNA interface [nucleotide binding]; other site
1218933012231	5S rRNA interface [nucleotide binding]; other site
1218933012232	putative antibiotic binding site [chemical binding]; other site
1218933012233	L25 interface [polypeptide binding]; other site
1218933012234	L27 interface [polypeptide binding]; other site
1218933012235	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1218933012236	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1218933012237	G-X-X-G motif; other site
1218933012238	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1218933012239	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1218933012240	protein-rRNA interface [nucleotide binding]; other site
1218933012241	putative translocon binding site; other site
1218933012242	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1218933012243	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1218933012244	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1218933012245	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1218933012246	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1218933012247	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1218933012248	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
1218933012249	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1218933012250	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
1218933012251	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
1218933012252	heme binding site [chemical binding]; other site
1218933012253	ferroxidase pore; other site
1218933012254	ferroxidase diiron center [ion binding]; other site
1218933012255	bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509
1218933012256	elongation factor Tu; Reviewed; Region: PRK00049
1218933012257	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1218933012258	G1 box; other site
1218933012259	GEF interaction site [polypeptide binding]; other site
1218933012260	GTP/Mg2+ binding site [chemical binding]; other site
1218933012261	Switch I region; other site
1218933012262	G2 box; other site
1218933012263	G3 box; other site
1218933012264	Switch II region; other site
1218933012265	G4 box; other site
1218933012266	G5 box; other site
1218933012267	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1218933012268	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1218933012269	Antibiotic Binding Site [chemical binding]; other site
1218933012270	elongation factor G; Reviewed; Region: PRK00007
1218933012271	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1218933012272	G1 box; other site
1218933012273	putative GEF interaction site [polypeptide binding]; other site
1218933012274	GTP/Mg2+ binding site [chemical binding]; other site
1218933012275	Switch I region; other site
1218933012276	G2 box; other site
1218933012277	G3 box; other site
1218933012278	Switch II region; other site
1218933012279	G4 box; other site
1218933012280	G5 box; other site
1218933012281	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1218933012282	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1218933012283	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1218933012284	30S ribosomal protein S7; Validated; Region: PRK05302
1218933012285	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1218933012286	S17 interaction site [polypeptide binding]; other site
1218933012287	S8 interaction site; other site
1218933012288	16S rRNA interaction site [nucleotide binding]; other site
1218933012289	streptomycin interaction site [chemical binding]; other site
1218933012290	23S rRNA interaction site [nucleotide binding]; other site
1218933012291	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1218933012292	sulfur transfer complex subunit TusB; Provisional; Region: PRK13510
1218933012293	sulfur relay protein TusC; Validated; Region: PRK00211
1218933012294	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
1218933012295	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
1218933012296	YheO-like PAS domain; Region: PAS_6; pfam08348
1218933012297	HTH domain; Region: HTH_22; pfam13309
1218933012298	putative metal dependent hydrolase; Provisional; Region: PRK11598
1218933012299	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
1218933012300	Sulfatase; Region: Sulfatase; pfam00884
1218933012301	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
1218933012302	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933012303	active site
1218933012304	phosphorylation site [posttranslational modification]
1218933012305	intermolecular recognition site; other site
1218933012306	dimerization interface [polypeptide binding]; other site
1218933012307	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1218933012308	DNA binding site [nucleotide binding]
1218933012309	sensor protein BasS/PmrB; Provisional; Region: PRK10755
1218933012310	HAMP domain; Region: HAMP; pfam00672
1218933012311	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1218933012312	dimer interface [polypeptide binding]; other site
1218933012313	phosphorylation site [posttranslational modification]
1218933012314	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933012315	ATP binding site [chemical binding]; other site
1218933012316	Mg2+ binding site [ion binding]; other site
1218933012317	G-X-G motif; other site
1218933012318	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1218933012319	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1218933012320	dimer interface [polypeptide binding]; other site
1218933012321	active site
1218933012322	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1218933012323	folate binding site [chemical binding]; other site
1218933012324	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1218933012325	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1218933012326	catalytic residue [active]
1218933012327	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1218933012328	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933012329	DNA-binding site [nucleotide binding]; DNA binding site
1218933012330	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1218933012331	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933012332	homodimer interface [polypeptide binding]; other site
1218933012333	catalytic residue [active]
1218933012334	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
1218933012335	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1218933012336	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1218933012337	SlyX; Region: SlyX; cl01090
1218933012338	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
1218933012339	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1218933012340	Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410
1218933012341	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
1218933012342	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
1218933012343	TrkA-N domain; Region: TrkA_N; pfam02254
1218933012344	glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930
1218933012345	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
1218933012346	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933012347	Walker A/P-loop; other site
1218933012348	ATP binding site [chemical binding]; other site
1218933012349	Q-loop/lid; other site
1218933012350	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1218933012351	ABC transporter signature motif; other site
1218933012352	Walker B; other site
1218933012353	D-loop; other site
1218933012354	ABC transporter; Region: ABC_tran_2; pfam12848
1218933012355	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1218933012356	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
1218933012357	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1218933012358	putative hydrolase; Provisional; Region: PRK10985
1218933012359	hypothetical protein; Provisional; Region: PRK04966
1218933012360	phosphoribulokinase; Provisional; Region: PRK15453
1218933012361	active site
1218933012362	hypothetical protein; Provisional; Region: PRK10738
1218933012363	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
1218933012364	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1218933012365	ligand binding site [chemical binding]; other site
1218933012366	flexible hinge region; other site
1218933012367	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1218933012368	putative switch regulator; other site
1218933012369	non-specific DNA interactions [nucleotide binding]; other site
1218933012370	DNA binding site [nucleotide binding]
1218933012371	sequence specific DNA binding site [nucleotide binding]; other site
1218933012372	putative cAMP binding site [chemical binding]; other site
1218933012373	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
1218933012374	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1218933012375	inhibitor-cofactor binding pocket; inhibition site
1218933012376	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933012377	catalytic residue [active]
1218933012378	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1218933012379	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1218933012380	glutamine binding [chemical binding]; other site
1218933012381	catalytic triad [active]
1218933012382	Pectate lyase; Region: Pec_lyase_C; cl01593
1218933012383	Pectate lyase; Region: Pec_lyase_C; cl01593
1218933012384	Pectate lyase; Region: Pec_lyase_C; pfam00544
1218933012385	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
1218933012386	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
1218933012387	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
1218933012388	active site
1218933012389	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1218933012390	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933012391	Walker A/P-loop; other site
1218933012392	ATP binding site [chemical binding]; other site
1218933012393	Q-loop/lid; other site
1218933012394	ABC transporter signature motif; other site
1218933012395	Walker B; other site
1218933012396	D-loop; other site
1218933012397	H-loop/switch region; other site
1218933012398	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1218933012399	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933012400	Walker A/P-loop; other site
1218933012401	ATP binding site [chemical binding]; other site
1218933012402	Q-loop/lid; other site
1218933012403	ABC transporter signature motif; other site
1218933012404	Walker B; other site
1218933012405	D-loop; other site
1218933012406	H-loop/switch region; other site
1218933012407	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1218933012408	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1218933012409	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1218933012410	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933012411	dimer interface [polypeptide binding]; other site
1218933012412	conserved gate region; other site
1218933012413	ABC-ATPase subunit interface; other site
1218933012414	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1218933012415	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933012416	dimer interface [polypeptide binding]; other site
1218933012417	conserved gate region; other site
1218933012418	putative PBP binding loops; other site
1218933012419	ABC-ATPase subunit interface; other site
1218933012420	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1218933012421	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
1218933012422	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1218933012423	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329
1218933012424	putative active site pocket [active]
1218933012425	metal binding site [ion binding]; metal-binding site
1218933012426	nitrite reductase subunit NirD; Provisional; Region: PRK14989
1218933012427	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1218933012428	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1218933012429	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1218933012430	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1218933012431	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
1218933012432	siroheme synthase; Provisional; Region: cysG; PRK10637
1218933012433	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1218933012434	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
1218933012435	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1218933012436	active site
1218933012437	SAM binding site [chemical binding]; other site
1218933012438	homodimer interface [polypeptide binding]; other site
1218933012439	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1218933012440	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933012441	dimer interface [polypeptide binding]; other site
1218933012442	conserved gate region; other site
1218933012443	putative PBP binding loops; other site
1218933012444	ABC-ATPase subunit interface; other site
1218933012445	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1218933012446	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933012447	dimer interface [polypeptide binding]; other site
1218933012448	conserved gate region; other site
1218933012449	putative PBP binding loops; other site
1218933012450	ABC-ATPase subunit interface; other site
1218933012451	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
1218933012452	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933012453	Walker A/P-loop; other site
1218933012454	ATP binding site [chemical binding]; other site
1218933012455	Q-loop/lid; other site
1218933012456	ABC transporter signature motif; other site
1218933012457	Walker B; other site
1218933012458	D-loop; other site
1218933012459	H-loop/switch region; other site
1218933012460	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1218933012461	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1218933012462	substrate binding pocket [chemical binding]; other site
1218933012463	membrane-bound complex binding site; other site
1218933012464	hinge residues; other site
1218933012465	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
1218933012466	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1218933012467	putative metal binding site [ion binding]; other site
1218933012468	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1218933012469	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1218933012470	active site
1218933012471	HIGH motif; other site
1218933012472	dimer interface [polypeptide binding]; other site
1218933012473	KMSKS motif; other site
1218933012474	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1218933012475	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1218933012476	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1218933012477	motif II; other site
1218933012478	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1218933012479	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
1218933012480	substrate binding site [chemical binding]; other site
1218933012481	hexamer interface [polypeptide binding]; other site
1218933012482	metal binding site [ion binding]; metal-binding site
1218933012483	DNA adenine methylase; Provisional; Region: PRK10904
1218933012484	hypothetical protein; Reviewed; Region: PRK11901
1218933012485	cell division protein DamX; Validated; Region: PRK10905
1218933012486	cell division protein DamX; Validated; Region: PRK10905
1218933012487	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1218933012488	active site
1218933012489	dimer interface [polypeptide binding]; other site
1218933012490	metal binding site [ion binding]; metal-binding site
1218933012491	shikimate kinase; Reviewed; Region: aroK; PRK00131
1218933012492	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1218933012493	ADP binding site [chemical binding]; other site
1218933012494	magnesium binding site [ion binding]; other site
1218933012495	putative shikimate binding site; other site
1218933012496	putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568
1218933012497	Secretin and TonB N terminus short domain; Region: STN; smart00965
1218933012498	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1218933012499	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1218933012500	Protein of unknown function (DUF2531); Region: DUF2531; pfam10748
1218933012501	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
1218933012502	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
1218933012503	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
1218933012504	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
1218933012505	Transglycosylase; Region: Transgly; pfam00912
1218933012506	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1218933012507	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
1218933012508	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1218933012509	ADP-ribose binding site [chemical binding]; other site
1218933012510	dimer interface [polypeptide binding]; other site
1218933012511	active site
1218933012512	nudix motif; other site
1218933012513	metal binding site [ion binding]; metal-binding site
1218933012514	Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095
1218933012515	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
1218933012516	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1218933012517	active site
1218933012518	motif I; other site
1218933012519	motif II; other site
1218933012520	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1218933012521	RNA binding surface [nucleotide binding]; other site
1218933012522	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1218933012523	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1218933012524	dimerization interface [polypeptide binding]; other site
1218933012525	domain crossover interface; other site
1218933012526	redox-dependent activation switch; other site
1218933012527	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1218933012528	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1218933012529	active site
1218933012530	substrate-binding site [chemical binding]; other site
1218933012531	metal-binding site [ion binding]
1218933012532	ATP binding site [chemical binding]; other site
1218933012533	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
1218933012534	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933012535	dimerization interface [polypeptide binding]; other site
1218933012536	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1218933012537	dimer interface [polypeptide binding]; other site
1218933012538	phosphorylation site [posttranslational modification]
1218933012539	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933012540	ATP binding site [chemical binding]; other site
1218933012541	Mg2+ binding site [ion binding]; other site
1218933012542	G-X-G motif; other site
1218933012543	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1218933012544	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933012545	active site
1218933012546	phosphorylation site [posttranslational modification]
1218933012547	intermolecular recognition site; other site
1218933012548	dimerization interface [polypeptide binding]; other site
1218933012549	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1218933012550	DNA binding site [nucleotide binding]
1218933012551	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1218933012552	ParB-like nuclease domain; Region: ParB; smart00470
1218933012553	ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048
1218933012554	Periplasmic binding protein TroA_f.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139
1218933012555	putative ligand binding residues [chemical binding]; other site
1218933012556	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933012557	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1218933012558	putative substrate translocation pore; other site
1218933012559	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1218933012560	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
1218933012561	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1218933012562	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1218933012563	dimer interface [polypeptide binding]; other site
1218933012564	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933012565	catalytic residue [active]
1218933012566	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842
1218933012567	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1218933012568	dimer interface [polypeptide binding]; other site
1218933012569	active site
1218933012570	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1218933012571	catalytic residues [active]
1218933012572	substrate binding site [chemical binding]; other site
1218933012573	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1218933012574	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933012575	N-terminal plug; other site
1218933012576	ligand-binding site [chemical binding]; other site
1218933012577	IucA / IucC family; Region: IucA_IucC; pfam04183
1218933012578	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1218933012579	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1218933012580	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
1218933012581	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1218933012582	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1218933012583	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
1218933012584	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1218933012585	putative acyl-acceptor binding pocket; other site
1218933012586	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
1218933012587	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1218933012588	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1218933012589	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933012590	dimer interface [polypeptide binding]; other site
1218933012591	putative CheW interface [polypeptide binding]; other site
1218933012592	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1218933012593	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1218933012594	dimer interface [polypeptide binding]; other site
1218933012595	active site
1218933012596	citrylCoA binding site [chemical binding]; other site
1218933012597	NADH binding [chemical binding]; other site
1218933012598	cationic pore residues; other site
1218933012599	oxalacetate/citrate binding site [chemical binding]; other site
1218933012600	coenzyme A binding site [chemical binding]; other site
1218933012601	catalytic triad [active]
1218933012602	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1218933012603	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1218933012604	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1218933012605	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1218933012606	RNA binding site [nucleotide binding]; other site
1218933012607	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1218933012608	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1218933012609	Bacterial transcriptional regulator; Region: IclR; pfam01614
1218933012610	2-keto-3-deoxygluconate permease; Region: KdgT; pfam03812
1218933012611	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
1218933012612	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1218933012613	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1218933012614	Walker A/P-loop; other site
1218933012615	ATP binding site [chemical binding]; other site
1218933012616	Q-loop/lid; other site
1218933012617	ABC transporter signature motif; other site
1218933012618	Walker B; other site
1218933012619	D-loop; other site
1218933012620	H-loop/switch region; other site
1218933012621	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1218933012622	dimer interface [polypeptide binding]; other site
1218933012623	Alkaline phosphatase homologues; Region: alkPPc; smart00098
1218933012624	active site
1218933012625	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1218933012626	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1218933012627	conserved cys residue [active]
1218933012628	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1218933012629	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1218933012630	aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555
1218933012631	Protein export membrane protein; Region: SecD_SecF; cl14618
1218933012632	carboxylesterase BioH; Provisional; Region: PRK10349
1218933012633	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1218933012634	DNA utilization protein GntX; Provisional; Region: PRK11595
1218933012635	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1218933012636	active site
1218933012637	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
1218933012638	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1218933012639	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
1218933012640	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
1218933012641	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
1218933012642	maltodextrin phosphorylase; Provisional; Region: PRK14985
1218933012643	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1218933012644	active site pocket [active]
1218933012645	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
1218933012646	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1218933012647	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1218933012648	intramembrane serine protease GlpG; Provisional; Region: PRK10907
1218933012649	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
1218933012650	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1218933012651	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
1218933012652	active site residue [active]
1218933012653	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
1218933012654	glycogen phosphorylase; Provisional; Region: PRK14986
1218933012655	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1218933012656	homodimer interface [polypeptide binding]; other site
1218933012657	active site pocket [active]
1218933012658	glycogen synthase; Provisional; Region: glgA; PRK00654
1218933012659	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1218933012660	ADP-binding pocket [chemical binding]; other site
1218933012661	homodimer interface [polypeptide binding]; other site
1218933012662	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
1218933012663	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1218933012664	ligand binding site; other site
1218933012665	oligomer interface; other site
1218933012666	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1218933012667	dimer interface [polypeptide binding]; other site
1218933012668	N-terminal domain interface [polypeptide binding]; other site
1218933012669	sulfate 1 binding site; other site
1218933012670	glycogen debranching enzyme; Provisional; Region: PRK03705
1218933012671	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1218933012672	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1218933012673	active site
1218933012674	catalytic site [active]
1218933012675	glycogen branching enzyme; Provisional; Region: PRK05402
1218933012676	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1218933012677	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1218933012678	active site
1218933012679	catalytic site [active]
1218933012680	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1218933012681	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1218933012682	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1218933012683	GAF domain; Region: GAF; pfam01590
1218933012684	Histidine kinase; Region: His_kinase; pfam06580
1218933012685	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933012686	ATP binding site [chemical binding]; other site
1218933012687	Mg2+ binding site [ion binding]; other site
1218933012688	G-X-G motif; other site
1218933012689	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
1218933012690	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1218933012691	putative antibiotic transporter; Provisional; Region: PRK10739
1218933012692	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1218933012693	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1218933012694	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1218933012695	ATP-binding site [chemical binding]; other site
1218933012696	Gluconate-6-phosphate binding site [chemical binding]; other site
1218933012697	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
1218933012698	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1218933012699	DNA binding site [nucleotide binding]
1218933012700	domain linker motif; other site
1218933012701	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1218933012702	putative ligand binding site [chemical binding]; other site
1218933012703	putative dimerization interface [polypeptide binding]; other site
1218933012704	Pirin-related protein [General function prediction only]; Region: COG1741
1218933012705	Pirin; Region: Pirin; pfam02678
1218933012706	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
1218933012707	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
1218933012708	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1218933012709	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
1218933012710	Cysteine-rich domain; Region: CCG; pfam02754
1218933012711	Cysteine-rich domain; Region: CCG; pfam02754
1218933012712	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
1218933012713	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1218933012714	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
1218933012715	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1218933012716	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1218933012717	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
1218933012718	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933012719	putative substrate translocation pore; other site
1218933012720	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
1218933012721	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
1218933012722	active site
1218933012723	catalytic site [active]
1218933012724	metal binding site [ion binding]; metal-binding site
1218933012725	putative hydrolase; Provisional; Region: PRK10976
1218933012726	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1218933012727	active site
1218933012728	motif I; other site
1218933012729	motif II; other site
1218933012730	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1218933012731	lysophospholipase L2; Provisional; Region: PRK10749
1218933012732	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1218933012733	homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520
1218933012734	threonine efflux system; Provisional; Region: PRK10229
1218933012735	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
1218933012736	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1218933012737	ATP binding site [chemical binding]; other site
1218933012738	putative Mg++ binding site [ion binding]; other site
1218933012739	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1218933012740	nucleotide binding region [chemical binding]; other site
1218933012741	ATP-binding site [chemical binding]; other site
1218933012742	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1218933012743	Helicase and RNase D C-terminal; Region: HRDC; smart00341
1218933012744	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
1218933012745	dimerization interface [polypeptide binding]; other site
1218933012746	substrate binding site [chemical binding]; other site
1218933012747	active site
1218933012748	calcium binding site [ion binding]; other site
1218933012749	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1218933012750	CoenzymeA binding site [chemical binding]; other site
1218933012751	subunit interaction site [polypeptide binding]; other site
1218933012752	PHB binding site; other site
1218933012753	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
1218933012754	EamA-like transporter family; Region: EamA; cl17759
1218933012755	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
1218933012756	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1218933012757	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1218933012758	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1218933012759	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
1218933012760	Cl binding site [ion binding]; other site
1218933012761	oligomer interface [polypeptide binding]; other site
1218933012762	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1218933012763	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
1218933012764	Part of AAA domain; Region: AAA_19; pfam13245
1218933012765	Family description; Region: UvrD_C_2; pfam13538
1218933012766	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
1218933012767	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1218933012768	motif II; other site
1218933012769	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
1218933012770	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1218933012771	active site
1218933012772	DNA binding site [nucleotide binding]
1218933012773	Int/Topo IB signature motif; other site
1218933012774	hypothetical protein; Provisional; Region: PRK10963
1218933012775	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1218933012776	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1218933012777	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1218933012778	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361
1218933012779	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
1218933012780	putative iron binding site [ion binding]; other site
1218933012781	adenylate cyclase; Provisional; Region: cyaA; PRK09450
1218933012782	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
1218933012783	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
1218933012784	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1218933012785	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1218933012786	domain interfaces; other site
1218933012787	active site
1218933012788	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
1218933012789	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1218933012790	active site
1218933012791	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
1218933012792	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
1218933012793	putative protoheme IX biogenesis protein; Provisional; Region: PRK10747
1218933012794	HemY protein N-terminus; Region: HemY_N; pfam07219
1218933012795	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1218933012796	TPR motif; other site
1218933012797	binding surface
1218933012798	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
1218933012799	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1218933012800	metal binding site [ion binding]; metal-binding site
1218933012801	dimer interface [polypeptide binding]; other site
1218933012802	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1218933012803	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1218933012804	Walker A/P-loop; other site
1218933012805	ATP binding site [chemical binding]; other site
1218933012806	Q-loop/lid; other site
1218933012807	ABC transporter signature motif; other site
1218933012808	Walker B; other site
1218933012809	D-loop; other site
1218933012810	H-loop/switch region; other site
1218933012811	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933012812	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1218933012813	dimer interface [polypeptide binding]; other site
1218933012814	conserved gate region; other site
1218933012815	putative PBP binding loops; other site
1218933012816	ABC-ATPase subunit interface; other site
1218933012817	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1218933012818	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1218933012819	substrate binding pocket [chemical binding]; other site
1218933012820	membrane-bound complex binding site; other site
1218933012821	hinge residues; other site
1218933012822	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1218933012823	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933012824	Coenzyme A binding pocket [chemical binding]; other site
1218933012825	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
1218933012826	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
1218933012827	tetramer interface [polypeptide binding]; other site
1218933012828	active site
1218933012829	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
1218933012830	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
1218933012831	catalytic core [active]
1218933012832	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
1218933012833	putative transport protein YifK; Provisional; Region: PRK10746
1218933012834	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1218933012835	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1218933012836	putative common antigen polymerase; Provisional; Region: PRK02975
1218933012837	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429
1218933012838	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
1218933012839	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1218933012840	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1218933012841	inhibitor-cofactor binding pocket; inhibition site
1218933012842	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933012843	catalytic residue [active]
1218933012844	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1218933012845	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933012846	Coenzyme A binding pocket [chemical binding]; other site
1218933012847	dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217
1218933012848	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1218933012849	NAD binding site [chemical binding]; other site
1218933012850	substrate binding site [chemical binding]; other site
1218933012851	homodimer interface [polypeptide binding]; other site
1218933012852	active site
1218933012853	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
1218933012854	TrkA-N domain; Region: TrkA_N; pfam02254
1218933012855	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1218933012856	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1218933012857	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1218933012858	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1218933012859	homodimer interface [polypeptide binding]; other site
1218933012860	active site
1218933012861	lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638
1218933012862	Chain length determinant protein; Region: Wzz; pfam02706
1218933012863	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119
1218933012864	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1218933012865	Mg++ binding site [ion binding]; other site
1218933012866	putative catalytic motif [active]
1218933012867	substrate binding site [chemical binding]; other site
1218933012868	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1218933012869	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1218933012870	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1218933012871	RNA binding site [nucleotide binding]; other site
1218933012872	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1218933012873	multimer interface [polypeptide binding]; other site
1218933012874	Walker A motif; other site
1218933012875	ATP binding site [chemical binding]; other site
1218933012876	Walker B motif; other site
1218933012877	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1218933012878	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1218933012879	catalytic residues [active]
1218933012880	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
1218933012881	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1218933012882	ATP binding site [chemical binding]; other site
1218933012883	Mg++ binding site [ion binding]; other site
1218933012884	motif III; other site
1218933012885	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1218933012886	nucleotide binding region [chemical binding]; other site
1218933012887	ATP-binding site [chemical binding]; other site
1218933012888	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
1218933012889	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1218933012890	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
1218933012891	Part of AAA domain; Region: AAA_19; pfam13245
1218933012892	Family description; Region: UvrD_C_2; pfam13538
1218933012893	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1218933012894	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
1218933012895	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
1218933012896	Predicted transcriptional regulator [Transcription]; Region: COG3905
1218933012897	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
1218933012898	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
1218933012899	Glutamate binding site [chemical binding]; other site
1218933012900	NAD binding site [chemical binding]; other site
1218933012901	catalytic residues [active]
1218933012902	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1218933012903	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1218933012904	Na binding site [ion binding]; other site
1218933012905	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933012906	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933012907	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1218933012908	dimerization interface [polypeptide binding]; other site
1218933012909	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1218933012910	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1218933012911	ketol-acid reductoisomerase; Validated; Region: PRK05225
1218933012912	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1218933012913	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1218933012914	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1218933012915	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933012916	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
1218933012917	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
1218933012918	putative dimerization interface [polypeptide binding]; other site
1218933012919	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
1218933012920	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
1218933012921	threonine dehydratase; Reviewed; Region: PRK09224
1218933012922	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1218933012923	tetramer interface [polypeptide binding]; other site
1218933012924	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933012925	catalytic residue [active]
1218933012926	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
1218933012927	putative Ile/Val binding site [chemical binding]; other site
1218933012928	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1218933012929	putative Ile/Val binding site [chemical binding]; other site
1218933012930	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
1218933012931	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1218933012932	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1218933012933	homodimer interface [polypeptide binding]; other site
1218933012934	substrate-cofactor binding pocket; other site
1218933012935	catalytic residue [active]
1218933012936	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
1218933012937	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
1218933012938	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1218933012939	dimer interface [polypeptide binding]; other site
1218933012940	PYR/PP interface [polypeptide binding]; other site
1218933012941	TPP binding site [chemical binding]; other site
1218933012942	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1218933012943	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1218933012944	TPP-binding site [chemical binding]; other site
1218933012945	dimer interface [polypeptide binding]; other site
1218933012946	putative ATP-dependent protease; Provisional; Region: PRK09862
1218933012947	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1218933012948	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1218933012949	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1218933012950	hypothetical protein; Provisional; Region: PRK11027
1218933012951	transcriptional regulator HdfR; Provisional; Region: PRK03601
1218933012952	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933012953	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1218933012954	dimerization interface [polypeptide binding]; other site
1218933012955	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1218933012956	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1218933012957	TM-ABC transporter signature motif; other site
1218933012958	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1218933012959	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1218933012960	TM-ABC transporter signature motif; other site
1218933012961	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1218933012962	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1218933012963	Walker A/P-loop; other site
1218933012964	ATP binding site [chemical binding]; other site
1218933012965	Q-loop/lid; other site
1218933012966	ABC transporter signature motif; other site
1218933012967	Walker B; other site
1218933012968	D-loop; other site
1218933012969	H-loop/switch region; other site
1218933012970	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1218933012971	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1218933012972	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
1218933012973	putative ligand binding site [chemical binding]; other site
1218933012974	glutamate racemase; Provisional; Region: PRK00865
1218933012975	vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641
1218933012976	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933012977	N-terminal plug; other site
1218933012978	ligand-binding site [chemical binding]; other site
1218933012979	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
1218933012980	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933012981	S-adenosylmethionine binding site [chemical binding]; other site
1218933012982	hypothetical protein; Provisional; Region: PRK11056
1218933012983	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
1218933012984	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1218933012985	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
1218933012986	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1218933012987	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1218933012988	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
1218933012989	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933012990	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1218933012991	dimerization interface [polypeptide binding]; other site
1218933012992	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1218933012993	FAD binding site [chemical binding]; other site
1218933012994	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1218933012995	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1218933012996	active site
1218933012997	metal binding site [ion binding]; metal-binding site
1218933012998	hexamer interface [polypeptide binding]; other site
1218933012999	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1218933013000	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1218933013001	domain linker motif; other site
1218933013002	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
1218933013003	putative dimerization interface [polypeptide binding]; other site
1218933013004	putative ligand binding site [chemical binding]; other site
1218933013005	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1218933013006	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933013007	dimer interface [polypeptide binding]; other site
1218933013008	ABC-ATPase subunit interface; other site
1218933013009	putative PBP binding loops; other site
1218933013010	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933013011	dimer interface [polypeptide binding]; other site
1218933013012	conserved gate region; other site
1218933013013	putative PBP binding loops; other site
1218933013014	ABC-ATPase subunit interface; other site
1218933013015	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1218933013016	hypothetical protein; Provisional; Region: PRK11622
1218933013017	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1218933013018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933013019	Walker A/P-loop; other site
1218933013020	ATP binding site [chemical binding]; other site
1218933013021	Q-loop/lid; other site
1218933013022	ABC transporter signature motif; other site
1218933013023	Walker B; other site
1218933013024	D-loop; other site
1218933013025	H-loop/switch region; other site
1218933013026	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
1218933013027	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
1218933013028	putative catalytic residues [active]
1218933013029	putative nucleotide binding site [chemical binding]; other site
1218933013030	putative aspartate binding site [chemical binding]; other site
1218933013031	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1218933013032	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1218933013033	cystathionine gamma-synthase; Provisional; Region: PRK08045
1218933013034	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1218933013035	homodimer interface [polypeptide binding]; other site
1218933013036	substrate-cofactor binding pocket; other site
1218933013037	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933013038	catalytic residue [active]
1218933013039	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
1218933013040	dimerization interface [polypeptide binding]; other site
1218933013041	DNA binding site [nucleotide binding]
1218933013042	corepressor binding sites; other site
1218933013043	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1218933013044	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1218933013045	Walker A/P-loop; other site
1218933013046	ATP binding site [chemical binding]; other site
1218933013047	Q-loop/lid; other site
1218933013048	ABC transporter signature motif; other site
1218933013049	Walker B; other site
1218933013050	D-loop; other site
1218933013051	H-loop/switch region; other site
1218933013052	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1218933013053	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
1218933013054	putative ligand binding residues [chemical binding]; other site
1218933013055	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1218933013056	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1218933013057	ABC-ATPase subunit  interface; other site
1218933013058	dimer interface [polypeptide binding]; other site
1218933013059	putative PBP binding regions; other site
1218933013060	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
1218933013061	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
1218933013062	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
1218933013063	primosome assembly protein PriA; Validated; Region: PRK05580
1218933013064	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1218933013065	ATP binding site [chemical binding]; other site
1218933013066	putative Mg++ binding site [ion binding]; other site
1218933013067	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1218933013068	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1218933013069	DNA binding site [nucleotide binding]
1218933013070	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
1218933013071	domain linker motif; other site
1218933013072	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
1218933013073	dimerization interface [polypeptide binding]; other site
1218933013074	ligand binding site [chemical binding]; other site
1218933013075	essential cell division protein FtsN; Provisional; Region: PRK10927
1218933013076	cell division protein FtsN; Provisional; Region: PRK12757
1218933013077	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1218933013078	active site
1218933013079	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1218933013080	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933013081	Walker A motif; other site
1218933013082	ATP binding site [chemical binding]; other site
1218933013083	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933013084	Walker B motif; other site
1218933013085	arginine finger; other site
1218933013086	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1218933013087	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1218933013088	UbiA prenyltransferase family; Region: UbiA; pfam01040
1218933013089	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
1218933013090	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074
1218933013091	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1218933013092	amphipathic channel; other site
1218933013093	Asn-Pro-Ala signature motifs; other site
1218933013094	glycerol kinase; Provisional; Region: glpK; PRK00047
1218933013095	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1218933013096	N- and C-terminal domain interface [polypeptide binding]; other site
1218933013097	active site
1218933013098	MgATP binding site [chemical binding]; other site
1218933013099	catalytic site [active]
1218933013100	metal binding site [ion binding]; metal-binding site
1218933013101	glycerol binding site [chemical binding]; other site
1218933013102	homotetramer interface [polypeptide binding]; other site
1218933013103	homodimer interface [polypeptide binding]; other site
1218933013104	FBP binding site [chemical binding]; other site
1218933013105	protein IIAGlc interface [polypeptide binding]; other site
1218933013106	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1218933013107	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1218933013108	putative active site [active]
1218933013109	ferredoxin-NADP reductase; Provisional; Region: PRK10926
1218933013110	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
1218933013111	FAD binding pocket [chemical binding]; other site
1218933013112	FAD binding motif [chemical binding]; other site
1218933013113	phosphate binding motif [ion binding]; other site
1218933013114	beta-alpha-beta structure motif; other site
1218933013115	NAD binding pocket [chemical binding]; other site
1218933013116	Predicted membrane protein [Function unknown]; Region: COG3152
1218933013117	Protein of unknown function (DUF1454); Region: DUF1454; pfam07305
1218933013118	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1218933013119	triosephosphate isomerase; Provisional; Region: PRK14567
1218933013120	substrate binding site [chemical binding]; other site
1218933013121	dimer interface [polypeptide binding]; other site
1218933013122	catalytic triad [active]
1218933013123	agmatine deiminase; Provisional; Region: PRK13551
1218933013124	agmatine deiminase; Region: agmatine_aguA; TIGR03380
1218933013125	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
1218933013126	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
1218933013127	putative active site; other site
1218933013128	catalytic triad [active]
1218933013129	putative dimer interface [polypeptide binding]; other site
1218933013130	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1218933013131	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1218933013132	Walker A/P-loop; other site
1218933013133	ATP binding site [chemical binding]; other site
1218933013134	Q-loop/lid; other site
1218933013135	ABC transporter signature motif; other site
1218933013136	Walker B; other site
1218933013137	D-loop; other site
1218933013138	H-loop/switch region; other site
1218933013139	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1218933013140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933013141	dimer interface [polypeptide binding]; other site
1218933013142	conserved gate region; other site
1218933013143	putative PBP binding loops; other site
1218933013144	ABC-ATPase subunit interface; other site
1218933013145	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1218933013146	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933013147	dimer interface [polypeptide binding]; other site
1218933013148	conserved gate region; other site
1218933013149	putative PBP binding loops; other site
1218933013150	ABC-ATPase subunit interface; other site
1218933013151	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1218933013152	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1218933013153	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1218933013154	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1218933013155	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1218933013156	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1218933013157	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1218933013158	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1218933013159	N-terminal plug; other site
1218933013160	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1218933013161	ligand-binding site [chemical binding]; other site
1218933013162	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1218933013163	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933013164	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1218933013165	dimerization interface [polypeptide binding]; other site
1218933013166	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
1218933013167	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1218933013168	active site
1218933013169	ADP/pyrophosphate binding site [chemical binding]; other site
1218933013170	dimerization interface [polypeptide binding]; other site
1218933013171	allosteric effector site; other site
1218933013172	fructose-1,6-bisphosphate binding site; other site
1218933013173	ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509
1218933013174	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1218933013175	putative arabinose transporter; Provisional; Region: PRK03545
1218933013176	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933013177	putative substrate translocation pore; other site
1218933013178	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
1218933013179	HicB family; Region: HicB; pfam05534
1218933013180	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
1218933013181	dimer interface [polypeptide binding]; other site
1218933013182	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
1218933013183	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933013184	active site
1218933013185	phosphorylation site [posttranslational modification]
1218933013186	intermolecular recognition site; other site
1218933013187	dimerization interface [polypeptide binding]; other site
1218933013188	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1218933013189	DNA binding site [nucleotide binding]
1218933013190	two-component sensor protein; Provisional; Region: cpxA; PRK09470
1218933013191	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1218933013192	dimerization interface [polypeptide binding]; other site
1218933013193	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1218933013194	dimer interface [polypeptide binding]; other site
1218933013195	phosphorylation site [posttranslational modification]
1218933013196	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933013197	ATP binding site [chemical binding]; other site
1218933013198	Mg2+ binding site [ion binding]; other site
1218933013199	G-X-G motif; other site
1218933013200	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
1218933013201	Protein of unknown function (DUF3142); Region: DUF3142; pfam11340
1218933013202	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1218933013203	Predicted permeases [General function prediction only]; Region: COG0679
1218933013204	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
1218933013205	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
1218933013206	putative active site [active]
1218933013207	catalytic site [active]
1218933013208	putative metal binding site [ion binding]; other site
1218933013209	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1218933013210	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1218933013211	Walker A/P-loop; other site
1218933013212	ATP binding site [chemical binding]; other site
1218933013213	Q-loop/lid; other site
1218933013214	ABC transporter signature motif; other site
1218933013215	Walker B; other site
1218933013216	D-loop; other site
1218933013217	H-loop/switch region; other site
1218933013218	TOBE domain; Region: TOBE_2; pfam08402
1218933013219	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1218933013220	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933013221	dimer interface [polypeptide binding]; other site
1218933013222	conserved gate region; other site
1218933013223	putative PBP binding loops; other site
1218933013224	ABC-ATPase subunit interface; other site
1218933013225	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1218933013226	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933013227	dimer interface [polypeptide binding]; other site
1218933013228	conserved gate region; other site
1218933013229	putative PBP binding loops; other site
1218933013230	ABC-ATPase subunit interface; other site
1218933013231	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
1218933013232	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1218933013233	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
1218933013234	Protein of unknown function (DUF4225); Region: DUF4225; pfam13988
1218933013235	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1218933013236	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933013237	DNA-binding site [nucleotide binding]; DNA binding site
1218933013238	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1218933013239	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1218933013240	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1218933013241	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1218933013242	putative aldolase; Validated; Region: PRK08130
1218933013243	intersubunit interface [polypeptide binding]; other site
1218933013244	active site
1218933013245	Zn2+ binding site [ion binding]; other site
1218933013246	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
1218933013247	putative transporter; Provisional; Region: PRK09821
1218933013248	GntP family permease; Region: GntP_permease; pfam02447
1218933013249	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1218933013250	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1218933013251	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933013252	dimer interface [polypeptide binding]; other site
1218933013253	putative CheW interface [polypeptide binding]; other site
1218933013254	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1218933013255	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1218933013256	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1218933013257	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933013258	dimer interface [polypeptide binding]; other site
1218933013259	putative CheW interface [polypeptide binding]; other site
1218933013260	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1218933013261	HAMP domain; Region: HAMP; pfam00672
1218933013262	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1218933013263	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933013264	dimer interface [polypeptide binding]; other site
1218933013265	putative CheW interface [polypeptide binding]; other site
1218933013266	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1218933013267	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1218933013268	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933013269	dimer interface [polypeptide binding]; other site
1218933013270	putative CheW interface [polypeptide binding]; other site
1218933013271	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1218933013272	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1218933013273	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933013274	homodimer interface [polypeptide binding]; other site
1218933013275	catalytic residue [active]
1218933013276	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614
1218933013277	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1218933013278	Walker A/P-loop; other site
1218933013279	ATP binding site [chemical binding]; other site
1218933013280	Q-loop/lid; other site
1218933013281	ABC transporter signature motif; other site
1218933013282	Walker B; other site
1218933013283	D-loop; other site
1218933013284	H-loop/switch region; other site
1218933013285	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
1218933013286	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1218933013287	Walker A/P-loop; other site
1218933013288	ATP binding site [chemical binding]; other site
1218933013289	Q-loop/lid; other site
1218933013290	ABC transporter signature motif; other site
1218933013291	Walker B; other site
1218933013292	D-loop; other site
1218933013293	H-loop/switch region; other site
1218933013294	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
1218933013295	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
1218933013296	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1218933013297	TM-ABC transporter signature motif; other site
1218933013298	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1218933013299	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1218933013300	TM-ABC transporter signature motif; other site
1218933013301	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1218933013302	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1218933013303	dimerization interface [polypeptide binding]; other site
1218933013304	ligand binding site [chemical binding]; other site
1218933013305	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1218933013306	Coenzyme A binding pocket [chemical binding]; other site
1218933013307	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
1218933013308	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1218933013309	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1218933013310	DNA binding residues [nucleotide binding]
1218933013311	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1218933013312	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
1218933013313	cell division protein FtsE; Provisional; Region: PRK10908
1218933013314	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933013315	Walker A/P-loop; other site
1218933013316	ATP binding site [chemical binding]; other site
1218933013317	Q-loop/lid; other site
1218933013318	ABC transporter signature motif; other site
1218933013319	Walker B; other site
1218933013320	D-loop; other site
1218933013321	H-loop/switch region; other site
1218933013322	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1218933013323	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1218933013324	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1218933013325	P loop; other site
1218933013326	GTP binding site [chemical binding]; other site
1218933013327	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1218933013328	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933013329	S-adenosylmethionine binding site [chemical binding]; other site
1218933013330	hypothetical protein; Provisional; Region: PRK10910
1218933013331	Domain of unknown function (DUF1820); Region: DUF1820; cl11545
1218933013332	Predicted membrane protein [Function unknown]; Region: COG3714
1218933013333	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
1218933013334	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1218933013335	metal-binding site [ion binding]
1218933013336	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1218933013337	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1218933013338	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
1218933013339	CPxP  motif; other site
1218933013340	hypothetical protein; Provisional; Region: PRK11212
1218933013341	hypothetical protein; Provisional; Region: PRK11615
1218933013342	major facilitator superfamily transporter; Provisional; Region: PRK05122
1218933013343	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933013344	putative substrate translocation pore; other site
1218933013345	inner membrane protein YhjD; Region: TIGR00766
1218933013346	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1218933013347	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1218933013348	substrate binding site [chemical binding]; other site
1218933013349	ATP binding site [chemical binding]; other site
1218933013350	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1218933013351	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1218933013352	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1218933013353	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
1218933013354	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1218933013355	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1218933013356	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1218933013357	metal binding site [ion binding]; metal-binding site
1218933013358	active site
1218933013359	I-site; other site
1218933013360	Protein of unknown function (DUF3260); Region: DUF3260; pfam11658
1218933013361	Protein of unknown function (DUF2636); Region: DUF2636; cl11897
1218933013362	cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045
1218933013363	Protein of unknown function (DUF2819); Region: DUF2819; pfam10995
1218933013364	Protein of unknown function (DUF2629); Region: DUF2629; pfam10945
1218933013365	YhjQ protein; Region: YhjQ; pfam06564
1218933013366	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1218933013367	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
1218933013368	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
1218933013369	DXD motif; other site
1218933013370	PilZ domain; Region: PilZ; pfam07238
1218933013371	cellulose synthase regulator protein; Provisional; Region: PRK11114
1218933013372	endo-1,4-D-glucanase; Provisional; Region: PRK11097
1218933013373	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
1218933013374	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1218933013375	binding surface
1218933013376	TPR motif; other site
1218933013377	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
1218933013378	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1218933013379	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1218933013380	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
1218933013381	EamA-like transporter family; Region: EamA; pfam00892
1218933013382	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
1218933013383	active site
1218933013384	catalytic residues [active]
1218933013385	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
1218933013386	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1218933013387	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1218933013388	homodimer interface [polypeptide binding]; other site
1218933013389	catalytic residue [active]
1218933013390	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
1218933013391	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
1218933013392	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1218933013393	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1218933013394	Domain of unknown function (DUF1795); Region: DUF1795; pfam08786
1218933013395	PAAR motif; Region: PAAR_motif; pfam05488
1218933013396	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1218933013397	RHS Repeat; Region: RHS_repeat; pfam05593
1218933013398	RHS Repeat; Region: RHS_repeat; pfam05593
1218933013399	RHS Repeat; Region: RHS_repeat; cl11982
1218933013400	RHS protein; Region: RHS; pfam03527
1218933013401	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1218933013402	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1218933013403	RHS protein; Region: RHS; pfam03527
1218933013404	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1218933013405	Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628
1218933013406	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1218933013407	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933013408	Walker A/P-loop; other site
1218933013409	ATP binding site [chemical binding]; other site
1218933013410	Q-loop/lid; other site
1218933013411	ABC transporter signature motif; other site
1218933013412	Walker B; other site
1218933013413	D-loop; other site
1218933013414	H-loop/switch region; other site
1218933013415	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1218933013416	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
1218933013417	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933013418	Walker A/P-loop; other site
1218933013419	ATP binding site [chemical binding]; other site
1218933013420	Q-loop/lid; other site
1218933013421	ABC transporter signature motif; other site
1218933013422	Walker B; other site
1218933013423	D-loop; other site
1218933013424	H-loop/switch region; other site
1218933013425	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1218933013426	dipeptide transporter; Provisional; Region: PRK10913
1218933013427	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1218933013428	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933013429	dimer interface [polypeptide binding]; other site
1218933013430	conserved gate region; other site
1218933013431	putative PBP binding loops; other site
1218933013432	ABC-ATPase subunit interface; other site
1218933013433	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1218933013434	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933013435	dimer interface [polypeptide binding]; other site
1218933013436	conserved gate region; other site
1218933013437	putative PBP binding loops; other site
1218933013438	ABC-ATPase subunit interface; other site
1218933013439	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1218933013440	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1218933013441	peptide binding site [polypeptide binding]; other site
1218933013442	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
1218933013443	DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430
1218933013444	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933013445	active site
1218933013446	phosphorylation site [posttranslational modification]
1218933013447	intermolecular recognition site; other site
1218933013448	dimerization interface [polypeptide binding]; other site
1218933013449	sensory histidine kinase DcuS; Provisional; Region: PRK11086
1218933013450	PAS domain; Region: PAS; smart00091
1218933013451	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933013452	ATP binding site [chemical binding]; other site
1218933013453	Mg2+ binding site [ion binding]; other site
1218933013454	G-X-G motif; other site
1218933013455	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1218933013456	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1218933013457	transmembrane helices; other site
1218933013458	putative transporter; Validated; Region: PRK03818
1218933013459	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1218933013460	TrkA-C domain; Region: TrkA_C; pfam02080
1218933013461	TrkA-C domain; Region: TrkA_C; pfam02080
1218933013462	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
1218933013463	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1218933013464	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1218933013465	putative dimer interface [polypeptide binding]; other site
1218933013466	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1218933013467	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1218933013468	putative dimer interface [polypeptide binding]; other site
1218933013469	hypothetical protein; Provisional; Region: PRK11616
1218933013470	Protein of unknown function (DUF3748); Region: DUF3748; pfam12566
1218933013471	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1218933013472	Protein of unknown function (DUF1471); Region: DUF1471; cl11507
1218933013473	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1218933013474	beta-galactosidase; Region: BGL; TIGR03356
1218933013475	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1218933013476	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1218933013477	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1218933013478	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1218933013479	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1218933013480	substrate binding pocket [chemical binding]; other site
1218933013481	membrane-bound complex binding site; other site
1218933013482	hinge residues; other site
1218933013483	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
1218933013484	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1218933013485	active site
1218933013486	dimer interface [polypeptide binding]; other site
1218933013487	non-prolyl cis peptide bond; other site
1218933013488	insertion regions; other site
1218933013489	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1218933013490	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933013491	dimer interface [polypeptide binding]; other site
1218933013492	conserved gate region; other site
1218933013493	putative PBP binding loops; other site
1218933013494	ABC-ATPase subunit interface; other site
1218933013495	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
1218933013496	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1218933013497	Walker A/P-loop; other site
1218933013498	ATP binding site [chemical binding]; other site
1218933013499	Q-loop/lid; other site
1218933013500	ABC transporter signature motif; other site
1218933013501	Walker B; other site
1218933013502	D-loop; other site
1218933013503	H-loop/switch region; other site
1218933013504	Protein of unknown function (DUF1471); Region: DUF1471; cl11507
1218933013505	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933013506	D-galactonate transporter; Region: 2A0114; TIGR00893
1218933013507	putative substrate translocation pore; other site
1218933013508	galactonate dehydratase; Provisional; Region: PRK14017
1218933013509	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
1218933013510	putative active site pocket [active]
1218933013511	putative metal binding site [ion binding]; other site
1218933013512	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
1218933013513	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1218933013514	active site
1218933013515	intersubunit interface [polypeptide binding]; other site
1218933013516	catalytic residue [active]
1218933013517	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
1218933013518	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
1218933013519	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1218933013520	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1218933013521	DNA-binding site [nucleotide binding]; DNA binding site
1218933013522	FCD domain; Region: FCD; pfam07729
1218933013523	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
1218933013524	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1218933013525	non-specific DNA binding site [nucleotide binding]; other site
1218933013526	salt bridge; other site
1218933013527	sequence-specific DNA binding site [nucleotide binding]; other site
1218933013528	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1218933013529	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933013530	Walker A/P-loop; other site
1218933013531	ATP binding site [chemical binding]; other site
1218933013532	Q-loop/lid; other site
1218933013533	ABC transporter signature motif; other site
1218933013534	Walker B; other site
1218933013535	D-loop; other site
1218933013536	H-loop/switch region; other site
1218933013537	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1218933013538	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1218933013539	Walker A/P-loop; other site
1218933013540	ATP binding site [chemical binding]; other site
1218933013541	Q-loop/lid; other site
1218933013542	ABC transporter signature motif; other site
1218933013543	Walker B; other site
1218933013544	D-loop; other site
1218933013545	H-loop/switch region; other site
1218933013546	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1218933013547	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1218933013548	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933013549	dimer interface [polypeptide binding]; other site
1218933013550	conserved gate region; other site
1218933013551	putative PBP binding loops; other site
1218933013552	ABC-ATPase subunit interface; other site
1218933013553	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1218933013554	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933013555	dimer interface [polypeptide binding]; other site
1218933013556	conserved gate region; other site
1218933013557	putative PBP binding loops; other site
1218933013558	ABC-ATPase subunit interface; other site
1218933013559	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1218933013560	active site
1218933013561	tetramer interface [polypeptide binding]; other site
1218933013562	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1218933013563	active site
1218933013564	tetramer interface [polypeptide binding]; other site
1218933013565	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1218933013566	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1218933013567	inhibitor site; inhibition site
1218933013568	active site
1218933013569	dimer interface [polypeptide binding]; other site
1218933013570	catalytic residue [active]
1218933013571	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1218933013572	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
1218933013573	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
1218933013574	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1218933013575	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1218933013576	dimerization interface [polypeptide binding]; other site
1218933013577	sugar phosphate phosphatase; Provisional; Region: PRK10513
1218933013578	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1218933013579	active site
1218933013580	motif I; other site
1218933013581	motif II; other site
1218933013582	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1218933013583	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1218933013584	beta-galactosidase; Region: BGL; TIGR03356
1218933013585	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1218933013586	active site
1218933013587	methionine cluster; other site
1218933013588	phosphorylation site [posttranslational modification]
1218933013589	metal binding site [ion binding]; metal-binding site
1218933013590	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1218933013591	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1218933013592	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1218933013593	active site
1218933013594	P-loop; other site
1218933013595	phosphorylation site [posttranslational modification]
1218933013596	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1218933013597	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1218933013598	DNA binding site [nucleotide binding]
1218933013599	domain linker motif; other site
1218933013600	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
1218933013601	dimerization interface (closed form) [polypeptide binding]; other site
1218933013602	ligand binding site [chemical binding]; other site
1218933013603	Cache domain; Region: Cache_1; pfam02743
1218933013604	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1218933013605	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1218933013606	dimer interface [polypeptide binding]; other site
1218933013607	putative CheW interface [polypeptide binding]; other site
1218933013608	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1218933013609	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933013610	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1218933013611	putative substrate translocation pore; other site
1218933013612	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
1218933013613	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933013614	Mg2+ binding site [ion binding]; other site
1218933013615	G-X-G motif; other site
1218933013616	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1218933013617	anchoring element; other site
1218933013618	dimer interface [polypeptide binding]; other site
1218933013619	ATP binding site [chemical binding]; other site
1218933013620	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1218933013621	active site
1218933013622	putative metal-binding site [ion binding]; other site
1218933013623	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1218933013624	recF protein; Region: recf; TIGR00611
1218933013625	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933013626	Walker A/P-loop; other site
1218933013627	ATP binding site [chemical binding]; other site
1218933013628	Q-loop/lid; other site
1218933013629	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1218933013630	ABC transporter signature motif; other site
1218933013631	Walker B; other site
1218933013632	D-loop; other site
1218933013633	H-loop/switch region; other site
1218933013634	DNA polymerase III subunit beta; Validated; Region: PRK05643
1218933013635	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1218933013636	putative DNA binding surface [nucleotide binding]; other site
1218933013637	dimer interface [polypeptide binding]; other site
1218933013638	beta-clamp/clamp loader binding surface; other site
1218933013639	beta-clamp/translesion DNA polymerase binding surface; other site
1218933013640	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1218933013641	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
1218933013642	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933013643	Walker A motif; other site
1218933013644	ATP binding site [chemical binding]; other site
1218933013645	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1218933013646	Walker B motif; other site
1218933013647	arginine finger; other site
1218933013648	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1218933013649	DnaA box-binding interface [nucleotide binding]; other site
1218933013650	membrane protein insertase; Provisional; Region: PRK01318
1218933013651	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1218933013652	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1218933013653	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1218933013654	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1218933013655	G1 box; other site
1218933013656	GTP/Mg2+ binding site [chemical binding]; other site
1218933013657	Switch I region; other site
1218933013658	G2 box; other site
1218933013659	Switch II region; other site
1218933013660	G3 box; other site
1218933013661	G4 box; other site
1218933013662	G5 box; other site
1218933013663	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1218933013664	HipA N-terminal domain; Region: Couple_hipA; pfam13657
1218933013665	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
1218933013666	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1218933013667	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1218933013668	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1218933013669	non-specific DNA binding site [nucleotide binding]; other site
1218933013670	salt bridge; other site
1218933013671	sequence-specific DNA binding site [nucleotide binding]; other site
1218933013672	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1218933013673	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1218933013674	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1218933013675	NADP binding site [chemical binding]; other site
1218933013676	Predicted transcriptional regulators [Transcription]; Region: COG1733
1218933013677	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1218933013678	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1218933013679	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
1218933013680	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933013681	putative substrate translocation pore; other site
1218933013682	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1218933013683	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380
1218933013684	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
1218933013685	Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462
1218933013686	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769
1218933013687	4Fe-4S binding domain; Region: Fer4; pfam00037
1218933013688	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1218933013689	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1218933013690	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1218933013691	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
1218933013692	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1218933013693	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1218933013694	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1218933013695	6-phosphogluconate phosphatase; Provisional; Region: PRK10563
1218933013696	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1218933013697	motif I; other site
1218933013698	active site
1218933013699	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933013700	dimer interface [polypeptide binding]; other site
1218933013701	conserved gate region; other site
1218933013702	putative PBP binding loops; other site
1218933013703	ABC-ATPase subunit interface; other site
1218933013704	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933013705	dimer interface [polypeptide binding]; other site
1218933013706	conserved gate region; other site
1218933013707	putative PBP binding loops; other site
1218933013708	ABC-ATPase subunit interface; other site
1218933013709	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1218933013710	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1218933013711	substrate binding pocket [chemical binding]; other site
1218933013712	membrane-bound complex binding site; other site
1218933013713	hinge residues; other site
1218933013714	benzoate transporter; Region: benE; TIGR00843
1218933013715	Benzoate membrane transport protein; Region: BenE; pfam03594
1218933013716	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1218933013717	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1218933013718	non-specific DNA binding site [nucleotide binding]; other site
1218933013719	salt bridge; other site
1218933013720	sequence-specific DNA binding site [nucleotide binding]; other site
1218933013721	Cupin domain; Region: Cupin_2; pfam07883
1218933013722	transcriptional regulator PhoU; Provisional; Region: PRK11115
1218933013723	PhoU domain; Region: PhoU; pfam01895
1218933013724	PhoU domain; Region: PhoU; pfam01895
1218933013725	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
1218933013726	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1218933013727	Walker A/P-loop; other site
1218933013728	ATP binding site [chemical binding]; other site
1218933013729	Q-loop/lid; other site
1218933013730	ABC transporter signature motif; other site
1218933013731	Walker B; other site
1218933013732	D-loop; other site
1218933013733	H-loop/switch region; other site
1218933013734	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
1218933013735	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933013736	dimer interface [polypeptide binding]; other site
1218933013737	conserved gate region; other site
1218933013738	putative PBP binding loops; other site
1218933013739	ABC-ATPase subunit interface; other site
1218933013740	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
1218933013741	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1218933013742	dimer interface [polypeptide binding]; other site
1218933013743	conserved gate region; other site
1218933013744	putative PBP binding loops; other site
1218933013745	ABC-ATPase subunit interface; other site
1218933013746	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1218933013747	substrate binding pocket [chemical binding]; other site
1218933013748	membrane-bound complex binding site; other site
1218933013749	hinge residues; other site
1218933013750	Protein of unknown function (DUF4026); Region: DUF4026; pfam13218
1218933013751	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779
1218933013752	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1218933013753	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1218933013754	glutaminase active site [active]
1218933013755	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1218933013756	dimer interface [polypeptide binding]; other site
1218933013757	active site
1218933013758	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1218933013759	dimer interface [polypeptide binding]; other site
1218933013760	active site
1218933013761	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
1218933013762	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1218933013763	Substrate binding site; other site
1218933013764	Mg++ binding site; other site
1218933013765	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1218933013766	active site
1218933013767	substrate binding site [chemical binding]; other site
1218933013768	CoA binding site [chemical binding]; other site
1218933013769	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
1218933013770	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1218933013771	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1218933013772	gamma subunit interface [polypeptide binding]; other site
1218933013773	epsilon subunit interface [polypeptide binding]; other site
1218933013774	LBP interface [polypeptide binding]; other site
1218933013775	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1218933013776	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1218933013777	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1218933013778	alpha subunit interaction interface [polypeptide binding]; other site
1218933013779	Walker A motif; other site
1218933013780	ATP binding site [chemical binding]; other site
1218933013781	Walker B motif; other site
1218933013782	inhibitor binding site; inhibition site
1218933013783	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1218933013784	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1218933013785	core domain interface [polypeptide binding]; other site
1218933013786	delta subunit interface [polypeptide binding]; other site
1218933013787	epsilon subunit interface [polypeptide binding]; other site
1218933013788	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1218933013789	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1218933013790	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1218933013791	beta subunit interaction interface [polypeptide binding]; other site
1218933013792	Walker A motif; other site
1218933013793	ATP binding site [chemical binding]; other site
1218933013794	Walker B motif; other site
1218933013795	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1218933013796	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1218933013797	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1218933013798	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1218933013799	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1218933013800	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1218933013801	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1218933013802	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1218933013803	F0F1 ATP synthase subunit I; Validated; Region: PRK08049
1218933013804	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1218933013805	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1218933013806	S-adenosylmethionine binding site [chemical binding]; other site
1218933013807	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1218933013808	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
1218933013809	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
1218933013810	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1218933013811	FMN-binding protein MioC; Provisional; Region: PRK09004
1218933013812	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
1218933013813	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1218933013814	putative DNA binding site [nucleotide binding]; other site
1218933013815	putative Zn2+ binding site [ion binding]; other site
1218933013816	AsnC family; Region: AsnC_trans_reg; pfam01037
1218933013817	Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502
1218933013818	motif 1; other site
1218933013819	dimer interface [polypeptide binding]; other site
1218933013820	active site
1218933013821	motif 2; other site
1218933013822	motif 3; other site
1218933013823	hypothetical protein; Provisional; Region: yieM; PRK10997
1218933013824	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
1218933013825	metal ion-dependent adhesion site (MIDAS); other site
1218933013826	regulatory ATPase RavA; Provisional; Region: PRK13531
1218933013827	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1218933013828	Walker A motif; other site
1218933013829	ATP binding site [chemical binding]; other site
1218933013830	Walker B motif; other site
1218933013831	arginine finger; other site
1218933013832	Protein of unknown function (DUF3763); Region: DUF3763; pfam12592
1218933013833	potassium transport protein Kup; Provisional; Region: trkD; PRK10745
1218933013834	potassium uptake protein; Region: kup; TIGR00794
1218933013835	sensor protein QseC; Provisional; Region: PRK10337
1218933013836	HAMP domain; Region: HAMP; pfam00672
1218933013837	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1218933013838	dimer interface [polypeptide binding]; other site
1218933013839	phosphorylation site [posttranslational modification]
1218933013840	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1218933013841	ATP binding site [chemical binding]; other site
1218933013842	Mg2+ binding site [ion binding]; other site
1218933013843	G-X-G motif; other site
1218933013844	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
1218933013845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1218933013846	active site
1218933013847	phosphorylation site [posttranslational modification]
1218933013848	intermolecular recognition site; other site
1218933013849	dimerization interface [polypeptide binding]; other site
1218933013850	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1218933013851	DNA binding site [nucleotide binding]
1218933013852	Periplasmic protein with OB-fold [Function unknown]; Region: COG3111
1218933013853	D-ribose pyranase; Provisional; Region: PRK11797
1218933013854	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
1218933013855	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1218933013856	Walker A/P-loop; other site
1218933013857	ATP binding site [chemical binding]; other site
1218933013858	Q-loop/lid; other site
1218933013859	ABC transporter signature motif; other site
1218933013860	Walker B; other site
1218933013861	D-loop; other site
1218933013862	H-loop/switch region; other site
1218933013863	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1218933013864	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1218933013865	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1218933013866	TM-ABC transporter signature motif; other site
1218933013867	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
1218933013868	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
1218933013869	ligand binding site [chemical binding]; other site
1218933013870	dimerization interface [polypeptide binding]; other site
1218933013871	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1218933013872	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1218933013873	substrate binding site [chemical binding]; other site
1218933013874	dimer interface [polypeptide binding]; other site
1218933013875	ATP binding site [chemical binding]; other site
1218933013876	transcriptional repressor RbsR; Provisional; Region: PRK10423
1218933013877	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1218933013878	DNA binding site [nucleotide binding]
1218933013879	domain linker motif; other site
1218933013880	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
1218933013881	dimerization interface [polypeptide binding]; other site
1218933013882	ligand binding site [chemical binding]; other site